President And Fellows Of Harvard College

RAPID EXPANSION OF ANTIRETROVIRAL THERAPY PROGRAMS

STATISTICAL AND DATA MANAGEMENT CENTER FOR THE AIDS CLINICAL TRIALS GROUP

PHACS - DATA AND OPERATIONS CENTER

STATISTICAL AND DATA MANAGEMENT CENTER-PEDIATRIC,ADOLESCENT, AND MATERNAL CTG

HARVARD CLINICAL AND TRANSLATIONAL SCIENCE CENTER

THE HARVARD CLINICAL AND TRANSLATIONAL SCIENCE CENTER

HARVARD CLINICAL AND TRANSLATIONAL SCIENCE CENTER (UL1)

PEDIATRIC HIV/AIDS COHORT STUDY (PHACS) 2020

HARVARD UNIVERSITY CENTER FOR AIDS RESEARCH

NEW ENGLAND REGIONAL CENTER OF EXCELLENCE FOR BIODEFENS*

GRADUATE RESEARCH FELLOWSHIP PROGRAM (GRFP)

NEW ENGLAND PRIMATE RESEARCH CENTER BASE GRANT

GRADUATE RESEARCH FELLOWSHIP PROGRAM (GRFP)

INTEGRATED HUMAN ORGAN-ON-CHIP MICROPHYSIOLOGICAL SYSTEMS

GRADUATE RESEARCH FELLOWSHIP PROGRAM (GRFP)

MICROBIAL ECOLOGY, PROTEOGENOMICS AND COMPUTATIONAL OPTIMA

CENTER FOR INTEGRATED QUANTUM MATERIALS

HARVARD CLINICAL AND TRANSLATIONAL SCIENCE CENTER - PROJECT SUMMARY/ ABSTRACT CLINICAL AND TRANSLATIONAL RESEARCH (CTR) ACROSS HARVARD IS CONDUCTED AT 17 INDEPENDENT AND GEOGRAPHICALLY DISPERSED INSTITUTIONS, INCLUDING HARVARD MEDICAL SCHOOL (HMS), HARVARD T. H. CHAN SCHOOL OF PUBLIC HEALTH, AND 15 HMS-AFFILIATED ACADEMIC HEALTH CARE CENTERS. EACH OF THESE INSTITUTIONS IS FISCALLY AND OPERATIONALLY INDEPENDENT WITH THEIR OWN GOVERNANCE, FACULTY, IRB, AND ELECTRONIC HEALTH RECORDS. HARVARD CATALYST (HC) SERVES AS THE SOLE COORDINATING ENTITY FOR CTR AND HAS BROUGHT THESE INSTITUTIONS TOGETHER AS A FEDERATED CTR NETWORK. SINCE 2008, HC HAS DEVELOPED A SUBSTANTIAL PORTFOLIO OF EDUCATIONAL AND CTR RESOURCES TO MEET THE NEEDS OF THE CTR WORKFORCE AT HARVARD AND, WHEN THEIR VALUE HAS BEEN DEMONSTRATED AT HARVARD, DISSEMINATED THEM TO THE CTSA CONSORTIUM. MOVING FORWARD, HC’S OVERARCHING VISION IS TO PARTNER WITH OUR CTR WORKFORCE, INSTITUTIONS, AND COMMUNITIES TO BECOME A LIVING CLINICAL AND TRANSLATIONAL SCIENCE (CTS) LEARNING LABORATORY. THE CTS LEARNING LABORATORY WILL CONTINUOUSLY ASSESS AND REASSESS THE HUB’S CTR STRENGTHS AND WEAKNESSES, DEVELOPING AND IMPLEMENTING PROGRAMMATIC INNOVATIONS TO IMPROVE THE EFFICIENCY, QUALITY, EFFECTIVENESS, AND IMPACT OF CTR. USING THE PRINCIPLES AND METHODOLOGIES OF CTS AND GUIDED BY A LOGIC MODEL, HC IS COMMITTED TO ACHIEVING THESE GOALS AND OVERCOMING TRANSLATIONAL ROADBLOCKS. SEVEN TRANSLATIONAL ROADBLOCKS HAVE BEEN PRIORITIZED THAT CAN BE MITIGATED OR OVERCOME: 1) EDUCATIONAL RESOURCES ARE NOT REACHING ALL LEARNERS AND HAVE BEEN FOCUSED ON INVESTIGATORS, RATHER THAN INVESTIGATIONAL TEAMS; 2) EXTENSIVE RESEARCH RESOURCES ARE FREQUENTLY INVISIBLE AND DIFFICULT TO ACCESS; 3) SUBSTANTIAL STRUCTURAL AND REGULATORY BARRIERS LIMIT CROSS-INSTITUTIONAL COLLABORATIONS; 4) RESEARCH AND CLINICAL DATA NEED TO BE CONNECTED AND THEIR ACCESS DEMOCRATIZED; 5) CTR WORKFORCE IS NOT SUFFICIENTLY DIVERSE AND MUST BE GROWN IN ALL DOMAINS; 6) THERE IS LIMITED ACCESS TO AND PARTICIPATION BY DIVERSE POPULATIONS IN RESEARCH; AND 7) INSUFFICIENT MECHANISMS EXIST TO SUPPORT IMPLEMENTATION OF CTR EVIDENCE INTO PRACTICE. HC WILL ALSO FOCUS ON BETTER UNDERSTANDING AND MEETING THE NEEDS OF EARLY-STAGE AND UNDERREPRESENTED IN MEDICINE INVESTIGATORS AND THEIR TEAMS, AS WELL AS DIVERSE PATIENT POPULATIONS AND COMMUNITIES, WHILE WORKING TO DIVERSIFY THE WORKFORCE AND REDUCE HEALTH INEQUITIES. MULTIPLE INITIATIVES ARE PROPOSED TO ADDRESS FIVE SPECIFIC AIMS: 1) TRAIN AND DIVERSIFY THE CTR WORKFORCE; 2) CONNECT TRAINEES AND CTR TEAMS WITH HC RESOURCES; 3) PARTNER WITH COMMUNITY STAKEHOLDERS TO IMPROVE RESEARCH PARTICIPATION; 4) DEMOCRATIZE HEALTH INFORMATICS; AND 5) USE CTS TO OVERCOME SIGNIFICANT CTR ROADBLOCKS. HC IS EAGER TO LEARN FROM OTHER CTSA HUBS AND IS COMMITTED TO DISSEMINATION AND SHARING ACROSS THE CTSA CONSORTIUM. THE INSIGHTS DERIVED FROM EMPLOYING CTS APPROACHES WILL BE USED TO OVERCOME TRANSLATIONAL ROADBLOCKS AND ADVANCE THE COLLECTIVE NATIONAL GOAL OF IMPROVING HUMAN HEALTH.

STATISTICAL AND DATA MANAGEMENT CENTER FOR THE AIDS CLINICAL TRAILS GROUP

THE ROLE OF PRIVATE PLANS IN MEDICARE

NEW COSTIMULATORY PATHWAYS: FUNCTIONS AND INTERACTIONS

SENSORIMOTOR PROCESSING, DECISION MAKING, AND INTERNAL STATES: TOWARDS A REALISTIC MULTISCALE CIRCUIT MODEL OF THE LARVAL ZEBRAFISH BRAIN

HEALTH AND AGING IN AFRICA: LONGITUDINAL STUDIES OF INDEPTH COMMUNITIES

COMPREHENSIVE SINGLE-CELL ATLAS OF THE DEVELOPING MOUSE BRAIN - PROJECT SUMMARY THE DEVELOPING MOUSE BRAIN IS A FOUNDATIONAL EXPERIMENTAL MODEL FOR INVESTIGATION OF THE ORIGINS OF CELL TYPES IN THE MAMMALIAN BRAIN. COMPREHENSIVE KNOWLEDGE OF MOUSE BRAIN DEVELOPMENT IS CRITICAL FOR COMPARATIVE STUDIES OF NEURODEVELOPMENTAL PROCESSES, WHICH ARE KEY TO UNDERSTANDING THE REMARKABLE EVOLUTIONARY INNOVATIONS THAT DISTINGUISH HUMANS FROM OTHER SPECIES. IN ADDITION, DEVELOPMENTAL INFORMATION ENABLES REFINING CELL TAXONOMY IN THE ADULT BRAIN BY INCORPORATING KNOWLEDGE OF CELL TYPE AND LINEAGE ORIGINS INTO ADULT CELL CLASSIFICATION. DESPITE THE TRANSFORMATIVE INSIGHTS ENABLED BY THE RECENTLY CREATED MOLECULAR ATLAS OF THE ADULT MOUSE BRAIN, WE CURRENTLY LACK A COMPREHENSIVE CENSUS OF CELL TYPES OF THE DEVELOPING MOUSE BRAIN, AND THE LINEAGE RELATIONSHIPS THAT LINK THEM TO THEIR ADULT COUNTERPARTS. HERE WE SEEK TO GENERATE A COMPREHENSIVE, SPATIALLY- AND TEMPORALLY-RESOLVED, CELLULAR-RESOLUTION ATLAS OF THE WHOLE DEVELOPING MOUSE BRAIN, SAMPLED AT HIGH RESOLUTION THROUGH THE ENTIRE PERIOD OF EMBRYONIC AND POSTNATAL BRAIN DEVELOPMENT (FROM E8.0 TO P28). WE WILL EMPLOY THREE COMPLEMENTARY APPROACHES TO GENERATE COMPREHENSIVE MULTI-OMIC SINGLE-CELL PROFILES: 10X GENOMICS SINGLE-CELL RNA-SEQ (SCRNA-SEQ), 10X GENOMICS MULTIOME (SIMULTANEOUS SINGLE-NUCLEUS RNA-SEQ AND ATAC-SEQ, FOR COMBINED TRANSCRIPTOMIC AND EPIGENOMIC PROFILING), AND SMART-SEQ3 (FOR FULL-LENGTH DEEP RNA-SEQUENCING). IN PARALLEL, WE WILL USE THE SPATIALLY RESOLVED TRANSCRIPTOMIC METHOD MERFISH ACROSS THE SAME DENSELY-SAMPLED TIMELINE, TO IDENTIFY THE SPATIAL DISTRIBUTION OF ALL CELL TYPES AND DYNAMIC CHANGES IN CELL STATES ACROSS THE ENTIRE MOUSE BRAIN. WE WILL APPLY COMPUTATIONAL METHODS TO PREDICT DEVELOPMENTAL LINEAGE RELATIONSHIPS FROM THESE SPATIALLY AND TEMPORALLY RESOLVED DATASETS, AND EXPERIMENTALLY VALIDATE LINEAGE RELATIONSHIPS THROUGH BOTH BARCODE-BASED IN VIVO LINEAGE TRACING AND BY FUNCTIONALLY TESTING CANDIDATE MOLECULAR EFFECTORS USING MULTIPLEXED IN UTERO CRISPR SCREENING (PERTURB-SEQ). FINALLY, WE WILL PILOT INTEGRATION OF DEVELOPMENTAL DATASETS ACROSS SPECIES, MAPPING SINGLE-CELL OMICS DATASETS FROM THE DEVELOPING HUMAN AND NON-HUMAN PRIMATE BRAINS ONTO THE COMPREHENSIVE MOUSE BRAIN DEVELOPING CELL TYPE ATLAS ESTABLISHED HERE, TO CREATE A COMPUTATIONAL ALIGNMENT OF DEVELOPMENTAL TIME THAT WILL ENABLE UNDERSTANDING OF DIFFERENTIAL REGULATION OF SPECIFIC DEVELOPMENTAL EVENTS ACROSS SPECIES. OVERALL, THIS PROJECT BRINGS TOGETHER A TEAM OF INVESTIGATORS WITH EXTENSIVE, DEMONSTRATED EXPERTISE IN BRAIN DEVELOPMENT, CIRCUITRY, SINGLE-CELL GENOMICS, AND ASSEMBLY OF BRAIN ATLASES TO PRODUCE A COMPREHENSIVE DEVELOPMENTAL BRAIN CELL ATLAS, INTENDED TO SERVE AS A FIRST-OF-ITS-KIND FOUNDATIONAL RESOURCE TO THE NEUROSCIENCE COMMUNITY FOR THE STUDY OF MECHANISMS OF MAMMALIAN BRAIN DEVELOPMENT AND NEURODEVELOPMENTAL DISORDERS. OUR PROPOSED PROJECT WILL CONTRIBUTE SUBSTANTIALLY TO THE OVERARCHING GOAL OF BICAN TO GENERATE FUNDAMENTAL KNOWLEDGE ON DIVERSE CELL TYPES AND THEIR THREE-DIMENSIONAL ORGANIZATIONAL PRINCIPLES IN THE BRAIN ACROSS LIFESPAN AND EVOLUTION.

FLYBASE: A DROSOPHILA GENOMIC AND GENETIC DATABASE

MEDICAL SCIENTISTS TRAINING PROGRAM

HSPH NIEHS CENTER FOR ENVIRONMENTAL HEALTH

HARVARD CLINICAL AND TRANSLATIONAL SCIENCE CENTER (UL1)

GRADUATE RESEARCH FELLOWSHIP PROGRAM (GRFP) -THE U.S. NATIONAL SCIENCE FOUNDATION (NSF) GRADUATE RESEARCH FELLOWSHIP PROGRAM (GRFP) IS A HIGHLY COMPETITIVE FEDERAL FELLOWSHIP PROGRAM. GRFP HELPS ENSURE THE QUALITY, VITALITY, AND STRENGTH OF THE SCIENTIFIC AND ENGINEERING WORKFORCE OF THE UNITED STATES. THE PROGRAM RECOGNIZES AND SUPPORTS OUTSTANDING GRADUATE STUDENTS WHO ARE PURSUING RESEARCH-BASED MASTER'S AND DOCTORAL DEGREES IN SCIENCE, TECHNOLOGY, ENGINEERING, AND MATHEMATICS (STEM), INCLUDING STEM EDUCATION, IN ALIGNMENT WITH THE NSF ACT AND THE CURRENT GRFP SOLICITATION. GRFP PROVIDES THREE YEARS OF FINANCIAL SUPPORT FOR THE GRADUATE EDUCATION OF INDIVIDUALS WHO HAVE DEMONSTRATED THEIR POTENTIAL FOR SIGNIFICANT ACHIEVEMENTS IN STEM. THIS AWARD SUPPORTS THE NSF GRADUATE RESEARCH FELLOWS PURSUING GRADUATE EDUCATION AT THIS AWARDEE INSTITUTION. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

GRADUATE RESEARCH FELLOWSHIP PROGRAM

COORDINATING CENTER FOR THE UNDIAGNOSED DISEASES NETWORK

THE HSPH EDUCATION AND RESEARCH CENTER FOR OCCUPATIONAL SAFETY AND HEALTH

INTEGRATED DISCOVERY AND DEVELOPMENT OF INNOVATIVE TB DIAGNOSTICS

DIAGNOSING THE UNKNOWN FOR CARE AND ADVANCING SCIENCE (DUCAS) - PROJECT SUMMARY IN OUR CURRENT HEALTHCARE SYSTEM, IT OFTEN TAKES YEARS BEFORE PATIENTS WITH RARE CONDITIONS AND RARE PRESENTATIONS OF COMMON CONDITIONS RECEIVE A DIAGNOSIS. IN 2013, THE NATIONAL INSTITUTES OF HEALTH SUPPORTED THE CREATION OF THE UNDIAGNOSED DISEASES NETWORK (UDN) TO ADDRESS THE NEEDS OF THESE PATIENTS, TO FACILITATE THE DIAGNOSTIC PROCESS FOR THOSE WITH UNDIAGNOSED CONDITIONS AND GENERATE NEW KNOWLEDGE ABOUT UNDERLYING MECHANISMS OF DISEASE. THE UDN WAS SUCCESSFUL IN SOLVING MEDICAL MYSTERIES, SHORTENING DIAGNOSTIC ODYSSEYS, AND CONTRIBUTING TO BIOMEDICAL RESEARCH DISCOVERY. IN ORDER TO SERVE MORE PATIENTS, THE UDN PROCESS MUST BE SCALED AND INTEGRATED INTO BROADER HEALTHCARE AND RESEARCH ECOSYSTEMS. AS THE DATA MANAGEMENT COORDINATING CENTER (DMCC) FOR A NETWORK OF DIAGNOSTIC CENTERS OF EXCELLENCE, HARVARD MEDICAL SCHOOL WILL LEVERAGE EXPERIENCE IN THE UDN TO CREATE SUSTAINABLE, NATIONALLY SCALED INFRASTRUCTURE TO SUPPORT DIAGNOSIS, RESEARCH, AND CARE FOR THOSE WHO ARE UNDIAGNOSED. THIS WILL BE ACCOMPLISHED BY BRINGING TOGETHER EXPERTS IN TRANS-INSTITUTIONAL DATA SHARING, DATA ANALYSIS, CLINICAL CARE, BIOINFORMATICS, NOVEL DIAGNOSTICS, AND TRANSLATIONAL RESEARCH AND CREATING THREE DMCC CORES - ADMINISTRATIVE, DATA MANAGEMENT, AND CLINICAL RESEARCH SUPPORT - TO ADDRESS UNMET NEEDS OF THE UNDIAGNOSED. THE ADMINISTRATIVE CORE WILL UNITE THE DMCC AND SUPPORT ACTIVITIES OF ALL THREE CORES. TOGETHER, THE DMCC CORES WILL ACCOMPLISH FOUR AIMS: 1) SCALE UP UDN THROUGHPUT BY AT LEAST AN ORDER OF MAGNITUDE TO MEET A PRESSING NATIONAL NEED, 2) LEVERAGE PARTNERSHIPS FOR SUSTAINABLE COORDINATION OF DIAGNOSTIC PROCESSES TO INCREASE PATIENT AUTONOMY WHILE ADVANCING OPPORTUNITIES FOR INVESTIGATIVE SCIENCE, 3) MAXIMIZE DATA MOBILITY, INTERPRETABILITY, AND SHAREABILITY, AND 4) PROVIDE ANALYTIC SERVICE AND DATA STEWARDSHIP THROUGH THE DATA MANAGEMENT CORE AND CLINICAL RESEARCH SUPPORT CORES LED BY EXPERTS IN GENOMICS AND AI TEAMING WITH CLINICIANS AND RESEARCHERS.

IMMGEN: A GENE EXPRESSION COMPENDIUM FOR IMMUNE CELLS

FLYBASE: A DROSOPHILA GENOMIC & GENETIC DATABASE

MIDAS CENTER FOR COMMUNICABLE DISEASE DYNAMICS

STATISTICAL AND DATA MANAGEMENT CENTER-PEDIATRIC,ADOLESCENT, AND MATERNAL CTG

TIME-TOLERANT BIOSTASIS THERAPEUTICS

INNOVATIVE PLATFORMS FOR ANTIMICROBIAL THERAPY AND VACCINE DEVELOPMENT

HSPH CENTER FOR EXCELLENCE TO PROMOTE A HEALTHIER WORKFORCE

BRAIN CONNECTS: A CENTER FOR HIGH-THROUGHPUT INTEGRATIVE MOUSE CONNECTOMICS - PROJECT SUMMARY/ABSTRACT THE PROPOSED PROJECT WILL DEMONSTRATE THE FEASIBILITY OF GENERATING A COMPLETE SYNAPSE-LEVEL BRAIN MAP (CONNECTOME) BY DEVELOPING A SERIAL-SECTION ELECTRON MICROSCOPY PIPELINE THAT COULD SCALE TO A WHOLE MOUSE BRAIN. THIS WORK WILL IMAGE 10 CUBIC MILLIMETERS, ITSELF AN UNPRECEDENTEDLY LARGE DATASET THAT MAY EXCEED TENS OF PETABYTES. YET THE MOUSE BRAIN IS 50 TIMES LARGER. REACHING THIS AMBITIOUS GOAL WILL REQUIRE ADVANCES IN WHOLE-BRAIN STAINING, IMAGING, IMAGE-PROCESSING, ANALYSIS, AND DISSEMINATION TOOLS. WE WILL SCALE AND TEST THESE TOOLS BY PRODUCING A CONNECTOME OF THE HIPPOCAMPAL FORMATION, A CRITICAL BRAIN REGION FOR MEMORY AND SPATIAL NAVIGATION. SPECIFICALLY, WE WILL DEFINE OUR VOLUME OF INTEREST VIA MICROCT SCANNING OF A WHOLE BRAIN. THEN WE WILL CUT IT INTO SEMITHIN SERIAL SECTIONS AND IMAGE THEM WITH MULTIBEAM SCANNING ELECTRON MICROSCOPY AND ION BEAM MILLING. THIS TECHNIQUE IMAGES A THIN LAYER OF TISSUE AND THEN REMOVES IT TO REVEAL THE NEXT LAYER UNTIL EACH SECTION IS FULLY IMAGED, MINIMIZING DISTORTIONS CAUSED BY PREVIOUS ULTRA-THIN SECTIONING APPROACHES. THE IMAGING DATA WILL BE PROCESSED BY AN IMPROVED VERSION OF OUR STATE-OF-THE-ART PIPELINE. AFTER QUALITY MONITORING AND IMAGE COMPRESSION, OUR AUTOMATED SYSTEM WILL ASSEMBLE THE FULL VOLUME FROM IMAGED SLICES AND THEN LABEL TISSUE ELEMENTS: NEURONS, GLIA, BLOOD VESSELS, MYELIN, CELL BODIES, AND SYNAPSES. THIS RECONSTRUCTION WILL THEN BE PROOFREAD AND REGISTERED TO THE ALLEN INSTITUTE BRAIN ATLAS, ALLOWING US TO RELATE OUR DATA TO OTHER TYPES OF DATA. OUR ANALYSIS WILL IDENTIFY CELL TYPES BY REGION AND LAYER, AND REVEAL THE DETAILED CONNECTIVITY OF HIPPOCAMPAL FORMATION CIRCUITS. USING CUSTOM SOFTWARE, WE WILL INTEGRATE THESE STRUCTURAL RESULTS ON CELL TYPES WITH OTHER APPROACHES BASED ON LIGHT MICROSCOPY AND SINGLE-CELL GENE EXPRESSION, ALLOWING US TO RELATE OUR RESULTS TO THE EXTENSIVE LITERATURE ON HIPPOCAMPAL FORMATION STRUCTURE AND FUNCTION. TO PROMOTE DIVERSE PERSPECTIVES, WE WILL INVOLVE UNDERGRADUATES FROM UNDERREPRESENTED BACKGROUNDS IN THE PROOFREADING AND SCIENTIFIC DISCOVERY PHASES OF OUR WORK, OFFERING THEM MENTORING AS WELL AS RESEARCH EXPERIENCE. WE WILL TURN THESE DATA INTO A LASTING RESOURCE FOR THE SCIENTIFIC COMMUNITY AND THE PUBLIC BY SCALING UP FREE ACCESS VIA ONLINE SHARING TOOLS TO ALLOW ANY INTERESTED PARTY TO RENDER, PROOFREAD, OR OTHERWISE ANALYZE THE CELLS AND CIRCUITS IN THIS VOLUME. TO ILLUSTRATE HOW THIS RESOURCE CAN BE COMBINED WITH OTHER DISCOVERIES, WE WILL DEFINE CELL TYPES BASED ON THEIR MORPHOLOGY AND CONNECTIVITY, CHARACTERIZE THE RELATIONSHIP BETWEEN THESE ASSIGNMENTS AND TRANSCRIPTOMIC-BASED CLASSIFICATIONS, AND INTEGRATE THIS INFORMATION WITH PREVIOUS WORK. FINALLY, WE WILL DEFINE LOCAL AND LONG-RANGE MICROCIRCUIT MOTIFS IN OUR DATA AND USE IT TO IDENTIFY CIRCUIT PRINCIPLES AND MECHANISMS OF MEMORY AND SPATIAL COGNITION, BY TESTING AND IMPROVING MODELS OF THE HIPPOCAMPAL FORMATION. THROUGHOUT THE PROJECT, WE WILL MONITOR KEY PERFORMANCE PARAMETERS, SUCH AS IMAGING THROUGHPUT OF A SINGLE MICROSCOPE, TO EVALUATE THE FEASIBILITY AND COST OF SCALING UP TO A WHOLE MOUSE BRAIN CONNECTOME.

NEW ENGLAND PRIMATE RESEARCH CENTER BASE GRANT

4D NUCLEOME NETWORK DATA COORDINATION AND INTEGRATION CENTER

THE PURPOSE OF THIS AGREEMENT IS TO FUND RESEARCH SUPPORTING THE DEFENSE ADVANCED RESEARCH PROJECTS AGENCY (DARPA) BIOLOGICAL TECHNOLOGIES OFFICE (BTO) PANACEA PROGRAM.

SMALL MOLECULE INHIBITORS OF ENVELOPED VIRUS ENTRY

LIFE COURSE CANCER EPIDEMIOLOGY COHORT IN WOMEN

MICROBIAL ECOLOGY, PROTEOGENO-MICS & COMPUTATIONAL OPTIMA

INTEGRATED MESOSCALE ARCHITECTURES FOR SUSTAINABLE CATALYSIS (IMASC)

DISSECTING THE ESTABLISHMENT AND REGULATION OF HUMAN PLURIPOTENCY