Silent Spring Institute Inc

ASSESSMENT OF PFAS EXPOSURES AND HEALTH EFFECTS IN TWO MASSACHUSETTS COMMUNITIES WITH PFAS DRINKING WATER CONTAMINATION

ETHICAL AND LEGAL CHALLENGES IN COMMUNICATING INDIVIDUAL BIOMONITORING AND PERSON

ASSESSMENT OF PEDIATRIC IMMUNOTOXICITY, PUBLIC EDUCATION, AND CAPACITY-BUILDING IN COMMUNITIES IMPACTED BY PFAS-CONTAMINATED DRINKING WATER

DATA SHARING AND PRIVACY PROTECTION IN DIGITAL-AGE ENVIRONMENTAL HEALTH STUDIES

FROM THE CELL TO THE STREET: PERSONALIZED REPORT-BACK IN LARGE COHORT STUDIES WITH MULTI-LEVEL MEASUREMENTS - PROJECT SUMMARY A GROWING CONSENSUS GIVES RESEARCHERS THE RESPONSIBILITY TO REPORT RESULTS BACK TO INDIVIDUAL PARTICIPANTS IN MOST STUDIES, BASED ON THE ETHICAL PRINCIPLES OF AUTONOMY, RESPECT, EQUITY, BENEFICENCE, AND TRUSTWORTHINESS. YET, ETHICAL REPORT-BACK OF RESEARCH RESULTS (RBRR) IS CONTEXT-SPECIFIC, REQUIRING CONSIDERATION OF THE PEOPLE AND DATA IN A PARTICULAR STUDY. NEW ADAPTATIONS ARE NEEDED, FOR EXAMPLE, TO ALIGN REPORT-BACK ETHICS WITH THE EMERGING SCIENCE OF THE EXPOSOME, DEFINED AS THE TOTALITY OF SOCIAL AND ENVIRONMENTAL FACTORS ACROSS THE LIFE CYCLE. EXPOSOME STUDIES GENERATE HUNDREDS OF MEASUREMENTS FROM MANY TECHNIQUES, INCLUDING GEOSPATIAL ASSESSMENTS OF NEIGHBORHOOD STRESSORS, BIOMONITORING FOR MULTIPLE CLASSES OF CHEMICALS, AND INDICATORS OF HEALTH-RELATED EFFECTS AT THE CELLULAR LEVEL. IMPORTANTLY, BECAUSE EXPOSOME STUDIES EVALUATE THE JOINT EFFECTS OF CHEMICAL MIXTURES AND SOCIAL STRESSORS, THEY ARE WELL- POSITIONED TO SUPPORT PARTICIPANTS WHO ARE GRAPPLING WITH EXPOSURES IN A CONTEXT OF ENVIRONMENTAL AND SOCIAL INJUSTICE, UNDERLINING THE VALUE OF RBRR TO PROMOTE EQUITY. TO SUPPORT ETHICAL PRACTICES IN EXPOSOME-FOCUSED STUDIES, THIS PROJECT WILL ADDRESS A KEY CHALLENGE – REPORT-BACK METHODS HAVE YET TO BE TESTED FOR LARGE NUMBERS OF MEASURES ACROSS MULTIPLE DOMAINS. THIS PROJECT WILL DEVELOP INNOVATIVE PARTICIPANT-CENTERED METHODS FOR PERSONALIZED RBRR FOR MULTI-LEVEL DATA IN LARGE STUDIES AND EVALUATE THESE METHODS IN TWO DIVERSE COHORTS RECRUITED DURING PREGNANCY: CHEMICALS IN OUR BODIES (CIOB, AT THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO AND BERKELEY) AND ILLINOIS KIDS DEVELOPMENT STUDY (IKIDS, AT THE UNIVERSITY OF ILLINOIS). IT WILL BUILD ON THE WELL-TESTED CAPABILITIES OF THE DIGITAL EXPOSURE REPORT-BACK INTERFACE (DERBI) TO GENERATE HIGH-QUALITY PERSONALIZED REPORTS FOR SMARTPHONE, COMPUTER, AND PRINT IN STUDIES OF ANY SIZE. AIM 1. USE PARTICIPATORY METHODS TO DEVELOP ETHICAL GUIDANCE FOR PERSONALIZED RBRR FOR MULTI-LEVEL DATA, INCLUDING LARGE CHEMICAL BIOMONITORING PANELS, GEOSPATIAL SOCIO-ENVIRONMENTAL INDICATORS, AND EARLY EFFECT BIOMARKERS. THIS AIM WILL BRING TOGETHER INPUT FROM PARTICIPANTS, RESEARCHERS, AND BIOETHICISTS, FIRST TO FOCUS ON CIOB/IKIDS AND THEN TO BROADEN INPUT AND DISCUSSION TO OTHER STUDIES. AIM 2. ENHANCE THE VALUE OF RBRR FOR PARTICIPANTS BY DEVELOPING DIGITAL TOOLS THAT SUPPORT PARTICIPANTS’ ABILITY TO TAKE ACTION AND OFFER THEM SCALABLE SOCIAL SUPPORT. DRAWING ON THEORIES OF HEALTH BEHAVIOR, A NEW DERBI FEATURE WILL OFFER OPPORTUNITIES FOR PARTICIPANTS TO IDENTIFY SOURCES OF HARMFUL CHEMICALS THAT ARE RELEVANT FOR THEM AND COMMIT TO INDIVIDUAL AND SOCIAL ACTIONS TO REDUCE EXPOSURES. PARTICIPANTS WILL BE INVITED TO A SOCIAL MEDIA GROUP. AIM 3. DEVELOP, DEPLOY, AND ASSESS PERSONALIZED RBRR FOR DIVERSE TYPES OF DATA IN CIOB/IKIDS. NEW CONTEXTUAL INFORMATION WILL BE DEVELOPED FOR DERBI TO HELP PARTICIPANTS INTERPRET NEW DATA TYPES, AND UPDATED DESIGN WILL DISTILL RESULTS ACROSS MULTIPLE DOMAINS. WE WILL RANDOMIZE HALF OF PARTICIPANTS TO TEST THE NEW DERBI TAKE-ACTION FEATURE. OUTCOME ASSESSMENTS INCLUDE FOLLOW-UP SURVEYS AND IN-DEPTH INTERVIEWS ABOUT EXPERIENCES AND ENVIRONMENTAL HEALTH LITERACY AS WELL AS DIGITAL ANALYTICS TO ASSESS PARTICIPANTS’ ENGAGEMENT WITH THEIR REPORTS.

PURPOSE: THE LEAD-BASED PAINT HAZARD REDUCTION (LHR) GRANT PROGRAM IS TO MAXIMIZE THE NUMBER OF CHILDREN UNDER THE AGE OF SIX PROTECTED FROM LEAD POISONING BY ASSISTING STATES, CITIES, COUNTIES/PARISHES, NATIVE AMERICAN TRIBES OR OTHER UNITS OF LOCAL GOVERNMENT IN UNDERTAKING COMPREHENSIVE PROGRAMS TO IDENTIFY AND CONTROL LEAD-BASED PAINT HAZARDS IN ELIGIBLE PRIVATELY-OWNED RENTAL OR OWNER-OCCUPIED HOUSING POPULATIONS. IN ADDITION, THERE IS HEALTHY HOMES SUPPLEMENTAL FUNDING AVAILABLE THAT IS INTENDED TO ENHANCE THE LEAD-BASED PAINT HAZARD CONTROL ACTIVITIES BY COMPREHENSIVELY IDENTIFYING AND ADDRESSING OTHER HOUSING HAZARDS THAT AFFECT OCCUPANT HEALTH. INFORMATION ABOUT WHERE THE SUPPLEMENTAL FUNDING CAN BE USED CAN BE FOUND AT. HTTPS://WWW.HUD.GOV/PROGRAM_OFFICES/HEALTHY_HOMES/PROJECT_DESCRIPTIONS; ACTIVITIES TO BE PERFORMED: PROGRAM FUNDS WILL BE AWARDED TO APPLICANTS TO ACCOMPLISH THE FOLLOWING OBJECTIVES: A. TARGETED UNITS: TARGET LEAD HAZARD CONTROL EFFORTS IN HOUSING UNITS WHERE CHILDREN LESS THAN 6 YEARS OF AGE ARE AT GREATEST RISK OF LEAD POISONING (PRE-1960, AND, ESPECIALLY, PRE-1940 CONSTRUCTION), WHICH HAS HISTORICALLY INCLUDED CHILDREN IN LOW-INCOME AND MINORITY NEIGHBORHOODS, TO REDUCE THE LIKELIHOOD OF ELEVATED BLOOD LEAD LEVELS IN THESE CHILDREN. B. COST EFFECTIVENESS: UTILIZE COST-EFFECTIVE LEAD HAZARD CONTROL METHODS AND APPROACHES THAT ENSURE THE LONG-TERM SAFETY OF THE BUILDING OCCUPANTS. C. CAPACITY: BUILD LOCAL CAPACITY OF TRAINED AND CERTIFIED INDIVIDUALS AND FIRMS TO ADDRESS LEAD HAZARDS SAFELY AND EFFECTIVELY DURING LEAD HAZARD CONTROL, RENOVATION, REMODELING, AND MAINTENANCE ACTIVITIES. ANOTHER CORE ELEMENT FOR CAPACITY INCLUDES THE DEVELOPMENT OF COMPREHENSIVE, COMMUNITY-BASED APPROACHES TO INTEGRATING THIS GRANT PROGRAM WITHIN OTHER LOCAL INITIATIVES THROUGH PUBLIC AND PRIVATE PARTNERSHIPS THAT ADDRESS HOUSING RELATED HEALTH AND SAFETY HAZARDS AND/OR SERVE LOW-INCOME FAMILIES WITH CHILDREN UNDER THE AGE OF SIX (6). D. AFFIRMATIVE MARKETING: ESTABLISH AND IMPLEMENT A DETAILED PROCESS OF MONITORING AND ENSURING THAT UNITS MADE LEAD-SAFE ARE AFFIRMATIVELY MARKETED, AND PRIORITY GIVEN, TO FAMILIES WITH CHILDREN UNDER AGE 6 YEARS FOR NOT LESS THAN THREE YEARS. E. DATA COLLECTION: GATHER PRE- AND POST-TREATMENT DATA THAT SUPPORTS AND VALIDATES LEAD HAZARD CONTROL INVESTMENTS. PROGRAM DATA COLLECTED SHOULD SUPPORT THE EVALUATION OF GRANT PROGRAM ACTIVITIES AND OUTCOMES. F. TARGETED OUTREACH AND EDUCATION: CONDUCTING TARGETED OUTREACH, AFFIRMATIVE MARKETING, EDUCATION OR OUTREACH PROGRAMS ON LEAD HAZARD CONTROL AND LEAD POISONING PREVENTION DESIGNED TO INCREASE THE ABILITY OF THE APPLICANT TO DELIVER THE SPECIFIED LEAD HAZARD CONTROL SERVICES THROUGH THIS PROGRAM; INCLUDING EDUCATING OWNERS OF ELIGIBLE RENTAL PROPERTIES, TENANTS, AND OTHERS ON THE BENEFITS AND EXPECTATIONS OF PARTICIPATING IN THIS PROGRAM PROVIDED BY "TITLE X" OF THE RESIDENTIAL LEAD-BASED PAINT HAZARD REDUCTION ACT OF 1992.; EXPECTED OUTCOMES: TO IDENTIFY AND CLEAN UP DANGEROUS LEAD IN LOW-INCOME FAMILIES’ HOMES WHERE LOW-INCOME FAMILIES WERE CHILDREN 6 AND UNDER RESIDE. THESE INVESTMENTS WILL PROTECT FAMILIES AND CHILDREN BY TARGETING SIGNIFICANT LEAD AND HEALTH HAZARDS IN OVER 3,700 LOW-INCOME HOMES FOR WHICH OTHER RESOURCES ARE NOT AVAILABLE.; INTENDED BENEFICIARIES: TO ASSIST STATES, CITIES, COUNTIES/PARISHES, NATIVE AMERICAN TRIBES OR OTHER UNITS OF LOCAL GOVERNMENT IN UNDERTAKING COMPREHENSIVE PROGRAMS TO IDENTIFY AND CONTROL LEAD-BASED PAINT HAZARDS IN ELIGIBLE PRIVATELY-OWNED RENTAL OR OWNER-OCCUPIED HOUSING POPULATIONS WERE CHILDREN UNDER 6 RESIDE.; SUBRECIPIENT ACTIVITIES: THE SUBRECIPIENT ACTIVITIES ARE UNKNOWN AT THE TIME OF AWARD.

LEAD-BASED PAINT HAZARD CONTROL IN PRIVATELY-OWNED HOUSING

HEALTHY HOMES OUTREACH

QUANTIFYING EARLY BIOMARKERS OF MAMMARY CARCINOGENESIS WITH MULTIPLEXED SPATIAL BIOLOGY - PROJECT SUMMARY/ ABSTRACT DR. JENNIFER KAY IS A TENURE TRACK-EQUIVALENT RESEARCH SCIENTIST AT SILENT SPRING INSTITUTE, AN INDEPENDENT, NON- PROFIT RESEARCH CENTER DEDICATED TO UNCOVERING ENVIRONMENTAL CAUSES OF BREAST CANCER AND OTHER WOMEN’S HEALTH ISSUES. DR. KAY DEVELOPS NEW APPROACHES TO IDENTIFY CHEMICAL EXPOSURES THAT INCREASE BREAST CANCER RISK AND QUANTIFY THEIR EFFECTS BY INTEGRATING MECHANISTIC EVIDENCE WITH EXPERIMENTAL AND OBSERVATIONAL STUDIES IN ANIMALS AND HUMANS. GENOTOXICITY AND/OR ENDOCRINE ACTIVITY ARE FEATURES OF MOST KNOWN HUMAN BREAST CARCINOGENS, AND THE COMBINATION OF CANCER INITIATION BY GENOTOXICITY AND PROMOTION BY ENDOCRINE SIGNALING IS PREDICTED TO INCREASE RISK COMPARED TO EITHER ALONE. DRAWING ON HER EXPERIENCE STUDYING MECHANISMS OF MUTAGENESIS AND CARCINOGENESIS IN THE LIVER, INTESTINES, AND LUNG, WITH THIS K01 CAREER DEVELOPMENT AWARD, SHE WILL INVESTIGATE THE MECHANISTIC INTERACTIONS OF ESTROGENICITY AND GENOTOXICITY IN BREAST CANCER USING A RODENT MODEL AND NOVEL MULTIPLEXED SPATIAL BIOLOGY APPROACHES. THIS AWARD WILL PROVIDE DR. KAY THE OPPORTUNITY TO 1) HONE GRANTSMANSHIP AND PROJECT MANAGEMENT SKILLS, 2) BECOME A LEADER IN BREAST CANCER PREVENTION AND TOXICOLOGY, AND 3) GENERATE NEW MECHANISTIC KNOWLEDGE THAT CAN SUPPORT HAZARD AND RISK PREDICTION. DR. KAY’S PRIMARY MENTOR, RUTHANN RUDEL, RESEARCH DIRECTOR OF SILENT SPRING INSTITUTE, WILL HELP HER DESIGN RESEARCH THAT CAN SHAPE CANCER RISK ASSESSMENT AND PREVENTION STRATEGIES, AND SHE WILL HELP DR. KAY TRANSLATE FINDINGS TO NATIONAL AND INTERNATIONAL SCIENTIFIC ORGANIZATIONS, GOVERNMENT DECISION MAKERS, AND LAY AUDIENCES. CO-MENTOR DR. LAURA VANDENBERG OF UNIVERSITY OF MASSACHUSETTS AMHERST—AN EXPERT IN RODENT MAMMARY GLAND BIOLOGY AND CARCINOGENESIS—WILL TRAIN HER IN DIVERSE TECHNIQUES FOR STUDYING CHEMICAL EFFECTS ON THE BREAST USING RATS. THE PROPOSED PROJECT, “QUANTIFYING EARLY BIOMARKERS OF MAMMARY CARCINOGENESIS WITH MULTIPLEXED SPATIAL BIOLOGY,” WILL CHARACTERIZE THE MECHANISTIC INTERACTIONS BETWEEN GENOTOXICITY AND ESTROGENICITY IN CHEMICALLY INDUCED MAMMARY CARCINOGENESIS. BIOMARKERS OF EFFECT WILL BE TRACKED IN MAMMARY TISSUE STRUCTURES AND EPITHELIAL CELL TYPES IN THE DAYS AND WEEKS AFTER EXPOSURE TO CHEMICALS THAT ARE GENOTOXIC, ESTROGENIC, OR BOTH, PRECEDING TUMOR DEVELOPMENT. EXPANDING UPON HER PREVIOUS EXPERIENCE WITH SPATIAL BIOLOGY AND QUANTITATIVE BIOIMAGING, DR. KAY WILL INTEGRATE MOLECULAR MARKERS MEASURED VIA MULTIPLEXED IMMUNOFLUORESCENCE WITH MICROSCOPIC ALTERATIONS TO TISSUE MORPHOLOGY IN ADJACENT HISTOPATHOLOGICAL SECTIONS AND STRUCTURAL EFFECTS IN WHOLE-MOUNT TISSUES. IN ADDITION, THIS PROJECT WILL, FOR THE FIRST TIME, MEASURE THE ABILITY FOR CHEMICAL EXPOSURES TO ALTER ESTRADIOL LEVELS IN MAMMARY TISSUE AS WELL AS SERUM. THIS RESEARCH ADVANCES NIEHS GOALS BY ENHANCING MECHANISTIC UNDERSTANDING OF ENDOCRINE DISRUPTION AND GENOTOXICITY IN BREAST CANCER, LAYING A FOUNDATION FOR ASSESSING CARCINOGENIC EFFECTS OF MIXTURES AND PREDICTING RISK WITH TOXICOLOGICAL METHODS THAT ARE MATCHED TO THE UNDERLYING PROCESSES. THE TOOLS DEVELOPED HERE CAN BE APPLIED TO STUDY MOLECULAR EFFECTS OF CARCINOGENS THAT ACT VIA OTHER MECHANISMS IN A WIDE RANGE OF TISSUES.

EXPANDING EFFECTIVE REPORT-BACK OF ENVIRONMENTAL EXPOSURES AMONG NEW RESEARCHERS AND CLINIC-BASED STUDIES - PROJECT SUMMARY BY REPORTING BACK TO STUDY PARTICIPANTS ON THEIR PERSONAL BIOMONITORING AND ENVIRONMENTAL EXPOSURE RESULTS, RESEARCHERS CAN ADVANCE ENVIRONMENTAL HEALTH LITERACY (EHL), EMPOWER INDIVIDUAL ACTIONS TO REDUCE HARMFUL CHEMICAL EXPOSURES, ACTIVATE CIVIC ENGAGEMENT IN POLICYMAKING, RESPECT RIGHT-TO-KNOW ETHICS, AND IMPROVE STUDY RECRUITMENT AND RETENTION. DESPITE THIS REPORT-BACK IS NOT YET A WIDESPREAD PRACTICE IN ENVIRONMENTAL HEALTH. WE HYPOTHESIZE THAT BARRIERS TO REPORT-BACK INCLUDE LIMITED FUNDING, INEXPERIENCE, AND CONCERNS ABOUT PARTICIPANT WORRY. IN LINE WITH THE DIFFUSION OF INNOVATION THEORY, WE EXPECT THAT A TRAINING PROGRAM WILL EXPAND RESEARCHER KNOWLEDGE OF REPORT-BACK ETHICS AND METHODS AND INCREASE THEIR WILLINGNESS AND ABILITY TO ENGAGE WITH THIS FORM OF COMMUNITY-BASED RESEARCH. WE ALSO HYPOTHESIZE THAT INVOLVING CLINICIANS WITH LITTLE PREVIOUS TRAINING IN ENVIRONMENTAL HEALTH WILL RESULT IN BROADLY ACCRUED BENEFITS, INCLUDING IMPROVED CLINICAL OUTCOMES AND CLINICIAN-PATIENT RELATIONSHIPS, HEIGHTENED STUDY ENGAGEMENT, AND INCREASED EHL FOR BOTH HEALTH PROFESSIONALS AND PATIENTS. THIS STUDY WILL USE SEMI-STRUCTURED INTERVIEWS AND PRE- AND POST-TESTS TO PURSUE THREE SPECIFIC AIMS: 1) IDENTIFY FACTORS THAT HINDER AND PROMOTE REPORT-BACK FOR INDIVIDUAL STUDIES AND FEDERALLY-FUNDED PROGRAMS; 2) EVALUATE A PROGRAM TO TRAIN RESEARCHERS TO PARTICIPATE IN REPORT-BACK; 3) DEVELOP EFFECTIVE STRATEGIES FOR ENGAGING HEALTH PRACTITIONERS IN REPORT-BACK AND ASSESS OUTCOMES FOR CLINICIANS AND PATIENTS. THIS RESEARCH IS INNOVATIVE BECAUSE IT IS THE FIRST TO STUDY THE CONSIDERATIONS OF INVESTIGATORS WHO DO NOT REPORT-BACK, AS WELL AS THE PERSPECTIVES AND EXPERIENCES OF FUNDING AGENCIES THAT SUPPORT THIS RESEARCH, SO THAT GUIDANCE AND TOOLS CAN BE DEVELOPED AND EVALUATED (AIM 1). FURTHERMORE, OUR PROJECT WILL CREATE A MODEL OF REPORT-BACK FOR THE LARGE NUMBER OF FEDERAL PROGRAMS AND FUNDING THAT SUPPORT ENVIRONMENTAL HEALTH MEASUREMENTS IN CLINICAL SETTINGS, INCLUDING MEGA-COHORTS LIKE ECHO, THE NIEHS’ SUPERFUND RESEARCH PROGRAM, AND NIH’S ALL OF US (AIM 2). BY PARTNERING WITH PREGNANCY AND EARLY CHILDHOOD COHORT STUDIES FOCUSED ON LOW-INCOME POPULATIONS AND COMMUNITIES OF COLOR, THE PROPOSED PROJECT WILL ALLOW US TO DEVELOP GUIDANCE ON REPORTING BACK FOR VULNERABLE POPULATIONS AND SENSITIVE PERIODS OF DEVELOPMENT, AN UNDERSTUDIED AREA OF RESEARCH. THE PROPOSED RESEARCH IS SIGNIFICANT BECAUSE IT WILL INCREASE RESEARCHER AND CLINICIAN KNOWLEDGE OF REPORT- BACK, HELP SURMOUNT BARRIERS TO ITS ADOPTION, DEVELOP NEW METHODS TO EVALUATE ITS EFFECTIVENESS, ENCOURAGE THE DEVELOPMENT OF FEDERAL GUIDANCE AND POLICIES ON REPORT-BACK, AND ADVANCE NIEHS’ STRATEGIC GOAL TO TRANSLATE DATA TO KNOWLEDGE TO ACTION.

SCALING UP ACCESS AND USABILITY OF SMARTPHONE TOOLS FOR REPORTING CHEMICAL BIOMONITORING RESULTS

LINKING BREAST CANCER ADVOCACY AND ENVIRONMENTAL JUSTICE

WOMEN'S HEALTH AND THE ENVIRONMENT: BREAST CANCER PREVENTION RESEARCH

WOMEN'S HEALTH AND THE ENVIRONMENT: BREAST CANCER PREVENTION RESEARCH

DESCRIPTION:THE GOAL OF THE PROPOSED RESEARCH IS TO BETTER CHARACTERIZE IMPORTANT EXPOSURE PATHWAYS OF PER- AND POLY-FLUOROALKYL SUBSTANCES (PFAS) AMONG VULNERABLE GROUPS, IN IMPACTED COMMUNITIES, AND IN THE GENERAL POPULATION. ACTIVITIES:THE PROJECT WILL COLLECT DATA THAT WILL ALLOW THE RECIPIENT TO EVALUATE HOW MUCH VARIABILITY IN PFAS SERUM LEVELS CAN BE EXPLAINED BY WATER CONSUMPTION AND OTHER RESIDENTIAL AND DIETARY EXPOSURE SOURCES/PATHWAYS SUCH AS INDOOR AIR. SUBRECIPIENT:A SUBAWARD WILL BE GIVEN TO INDIANA UNIVERSITY TO PERFORM PFAS ANALYSIS OF 50 PASSIVE INDOOR AIR AND 50 DUST SAMPLES COLLECTED IN PARTICIPANT HOMES, WITH THE ANALYSES TO BE CONDUCTED IN YEAR 1. OUTCOMES:THE ANTICIPATED DELIVERABLES ARE ANNUAL PROGRESS AND FINAL REPORTS. PROJECT OUTPUTS INCLUDE 1) EXPOSURE MEASUREMENTS (INDOOR AIR CONCENTRATIONS, HOUSEHOLD DUST CONCENTRATIONS) FOR 37 PFAS CHEMICALS AND QUESTIONNAIRE DATA FROM 50 HOMES CONCORDANT WITH BIOMONITORING DATA, 2) TOTAL FLUORINE (TF) AND EXTRACTABLE ORGANOFLUORINE (EOF) CONCENTRATIONS LEVELS IN 50 HOUSE DUST SAMPLES, 3) EVALUATED PROTOCOLS AND SOPS FOR MEASURING A TARGETED SET OF PFAS IN THE RESIDENTIAL ENVIRONMENT, INCLUDING DRINKING WATER; AND 4) PRELIMINARY ASSESSMENT OF RESIDENTIAL EXPOSURES, INCLUDING RELATIONSHIP BETWEEN MEASURED INDOOR AIR AND HOUSE DUST CONCENTRATIONS AND ASSOCIATIONS WITH HOUSING CHARACTERISTICS AND BEHAVIORS RELATED TO CONSUMER PRODUCTS WITHIN THE HOME. DIRECT BENEFICIARIES ARE STATE AND LOCAL PUBLIC HEALTH MANAGERS, THE SCIENTIFIC COMMUNITY, AND COMMUNITIES AFFECTED BY RESIDENTIAL PFAS EXPOSURE.

BUILDING ENVIRONMENTAL HEALTH LITERACY: WHAT SHOULD PEOPLE KNOW ABOUT ENDOCRINE DISRUPTING COMPOUNDS?

WOMEN'S HEALTH AND THE ENVIRONMENT: BREAST CANCER PREVENTION RESEARCH