Guide Inc

RECOVERY ACT GREEN JOBS

OHIOGUIDESTONE CLEVELAND, OHIO CCBHC PROJECT - THE OHIOGUIDESTONE CLEVELAND, OHIO CCBHC WILL EXPAND AND ENHANCE BEHAVIORAL HEALTH SERVICES FOR ADULTS WITH SMI, CHILDREN AND YOUTH WITH SED, AND YOUTH AND ADULTS WITH SUD/COD. OGS PROPOSES TO EXPAND ACCESS FOR TRANSITIONAL YOUTH AND HOMELESS EXPERIENCING SUD, COD CO-MORBID PHYSICAL HEALTH CONDITIONS, OR AN ELEVATED RISK OR NEED FOR CRISIS SERVICES IN THE CLEVELAND AREA OF CUYAHOGA COUNTY OHIO. OGS WILL ALSO EXPAND SERVICES FOR PREGNANT AND PARENTING WOMEN. THE OHIO STATE HEALTH IMPROVEMENT PLAN HAS DESIGNATED MATERNAL AND INFANT HEALTH AS A PRIORITY. THE OGS CUYAHOGA COUNTY CCBHC WILL SERVE 400 INDIVIDUALS IN YEAR ONE AND 600 IN YEAR 3 AND 4 RESPECTIVELY. THE NATIONAL SURVEY ON DRUG USE AND HEALTH, 2017-2018 AND AMERICAN COMMUNITY SURVEY, 2018 ESTIMATED 34,425 ADULTS 18 AND OLDER HAD SMI AND AN ESTIMATED 14,241 ADULTS HAD CO-OCCURRING MAJOR DEPRESSIVE EPISODE (MDE) AND SUD IN THE PAST YEAR IN THE PAST YEAR IN CUYAHOGA COUNTY, OH. WITHIN THE CATCHMENT AREA AN AVERAGE OF 11% UNEMPLOYMENT RATE AND 21.8% OF RESIDENTS LIVE AT LESS THAN 100% FPL (FEDERAL POVERTY LEVEL), THERE ARE 73,455 SINGLE PARENT HOUSEHOLDS AND 9,500 WOMEN WERE PREGNANT OR GAVE BIRTH IN THE PREVIOUS YEAR. THE DEMAND FOR HIGHLY RESPONSIVE COMMUNITY-BASED CARE IS HIGH, AND PER THE MOST RECENT CHNA, THERE ARE LIMITED SERVICES FOR MOTHERS WHO HAVE CHILDREN AND/OR WHO MAY BE PREGNANT. THE COORDINATED, INTEGRATED AND EVIDENCE-BASED LOCAL INTERVENTIONS CRITICAL TO EFFECTIVELY ENGAGING AND SUPPORTING TRANSITION AGE YOUTH WERE ALSO IDENTIFIED AS A SIGNIFICANT BARRIER IN CLEVELAND. ACCORDING TO THE UNITED WAY OF CLEVELAND 2019 NEEDS ASSESSMENT MORE THAN 1/3 OF PEOPLE WHO WERE HOMELESS IN CUYAHOGA COUNTY SUFFERED FROM CHRONIC SUBSTANCE USE DISORDER, AND MORE THAN A 1/3 SUFFERED FROM SMI. ADDITIONALLY, INDIVIDUALS SUFFERING FROM SMI CAN COST TAXPAYERS MORE THAN $40,000 PER YEAR WHILE HOMELESS. IN THE WAKE OF THE PANDEMIC, RATES OF HOMELESSNESS ARE RISING IN CLEVELAND. ADULTS, FAMILIES, AND YOUTH WHO ARE HOMELESS REQUIRE ACCESSIBLE, INTEGRATED, AND TRAUMA INFORMED CARE. OGS PROPOSES THE FOLLOWING GOALS SHOULD WE BE A CCBHC GRANT AWARDEE. GOAL 1: INCREASE CAPACITY AND TARGETED SERVICES TO FAMILIES AND CAREGIVERS IN THE TARGETED GEOGRAPHIC AREA. ESTIMATED 10 PERCENT OF PARTICIPANT SIBLINGS WHO ARE ELIGIBLE AND CHOOSE TO ENGAGE; 20 PERCENT CAREGIVERS OF PARTICIPANTS WHO ARE ELIGIBLE AND CHOOSE TO ENGAGE. GOAL 2: IMPROVE INTEGRATED REFERRALS AND CARE COORDINATION WITH PHYSICAL HEALTH PARTNERS TO ACHIEVE BETTER BH AND PHYSICAL HEALTH OUTCOMES FOR SED AND SMI POPULATION. GOAL 3: EXPAND SUBSTANCE USE AND CO-OCCURRING DISORDER TREATMENT FOR TRANSITIONAL AGE. GOAL 4: MONITOR AND INCREASE SERVICE DELIVERY OF CO-OCCURRING MENTAL HEALTH AND SUBSTANCE USE DISORDER DIAGNOSES AND CO-MORBID PHYSICAL HEALTH CONDITIONS OR AN ELEVATED RISK OR NEED FOR CRISIS SERVICES OR CHRONICALLY HOMELESS. GOAL 5: EXPAND INTERNAL CAPACITY AND ELEVATE STAFF COMPETENCY FOR BH SERVICES FOR UNDER RESOURCED PREGNANT OR PARENTING WOMEN TO POSITIVELY IMPACT HEALTH DISPARITIES.

OHIOGUIDESTONE FOUR-COUNTY OHIO CCHBC PROJECT - THE OHIOGUIDESTONE NORTHWESTERN OHIO CCBHC PROGRAM SEEKS TO CREATE A CERTIFIED COMMUNITY BEHAVIORAL HEALTH CLINIC SERVING THE FOUR COUNTY REGION CONSISTING OF FULTON, DEFIANCE, HENRY AND WILLIAMS COUNTIES IN NORTHWEST OHIO. OHIOGUIDESTONE WILL SERVE AS A FACILITATOR AND PROVIDER FOR THE INTEGRATION OF SERVICES DELIVERED TO ALL CLIENTS IN THE IDENTIFIED CATCHMENT AREA WITH A STRONG FOCUS ON THOSE THAT PRESENT WITH: CO-OCCURRING DIAGNOSIS, CO-MORBID PHYSICAL HEALTH CONDITIONS OR AN ELEVATED RISK OR NEED FOR CRISIS SERVICES (SPMI / SED). SERVICES WILL ALSO FOCUS ON DEEP-ENDED ADULTS, MULTI-SYSTEMIC YOUTH, AND VETERANS WITH A LACK OF AVAILABLE RESOURCES FOR BEHAVIORAL HEALTH TREATMENT. THE PROGRAM SEEKS TO SERVE 200 CLIENTS IN YEAR ONE AND 300 CLIENTS IN YEAR TWO, THREE, AND FOUR, FOR A TOTAL OF 1100 CLIENTS SERVED OVER THE TWO-YEAR FUNDING PERIOD. ITS GOALS ARE AS FOLLOWS: GOAL 1: PROVIDE ACCESS TO A SPECTRUM OF SERVICES THAT WILL SERVE 1100 CLIENTS IN THE GRANT GEOGRAPHIC CATCHMENT AREA, REGARDLESS OF ABILITY TO PAY, THAT INCLUDES 24/7 CRISIS SERVICES, HEALTH CARE, CARE COORDINATION, PHARMACOTHERAPY, MENTAL HEALTH AND SUBSTANCE USE DISORDER TREATMENT, PEER AND FAMILY SUPPORT. GOAL 2: PROVIDE CRISIS SERVICES TO THE CATCHMENT AREA WITH A 3 HOUR RESPONSE TIME. GOAL 3: RAISE COMMUNITY AWARENESS OF THE AVAILABILITY AND SERVICES OF CCBHC THAT TARGETS THOSE UNINSURED, OR “UNDER INSURED” WHO EXPERIENCE POVERTY WITH AN ADDITIONAL EMPHASIS ON ACTIVE MILITARY SERVICE AND VETERANS WHO RESIDE IN THE GRANT CATCHMENT AREA. GOAL 4: IMPROVE PRIMARY HEALTH CARE AND BEHAVIORAL HEALTH CARE THROUGH INTEGRATED PARTNERSHIPS. GOAL 5: ENSURE COMMUNITY INVOLVEMENT AND SATISFACTION BY ESTABLISHING A CCBHC ADVISORY WORK GROUP COMPRISED OF INDIVIDUALS WITH MENTAL HEALTH AND SUBSTANCE USE DISORDERS, FAMILY MEMBERS, AND COMMUNITY PARTNERS WHO WILL INFORM AND SHAPE OHIOGUIDESTONE’S CCBHC SERVICES. OHIOGUIDESTONE TREATMENT PROGRAMS ARE TRAUMA-INFORMED AND RELY ON A RANGE OF EVIDENCE-BASED TREATMENT MODALITIES, INCLUDING COGNITIVE BEHAVIORAL THERAPY (CBT), MOTIVATIONAL ENHANCEMENT THERAPY (MET), DIALECTICAL BEHAVIORAL THERAPY (DBT), TRAUMA-FOCUSED COGNITIVE BEHAVIORAL THERAPY (TF-CBT), ASSERTIVE COMMUNITY TREATMENT (ACT), INTENSIVE HOME-BASED TREATMENT (IHBT). OHIOGUIDESTONE HAS SIGNIFICANTLY EXPANDED THE SERVICES AND SUPPORTS WE PROVIDE TO INDIVIDUALS SUFFERING WITH SUBSTANCE USE DISORDERS OVER THE PAST DECADE. OUR CONTINUUM OF CARE INCLUDES SUBSTANCE USE PREVENTION PROGRAMS, INTENSIVE (IOP) AND NON-INTENSIVE OUTPATIENT COUNSELING, RECOVERY SUPPORT GROUPS, PSYCHIATRIC SERVICES AND MEDICATION-ASSISTED TREATMENT (MAT), AS WELL AS RECOVERY HOUSING AND PEER SUPPORT SERVICES. OHIOGUIDESTONE ALSO HAS THE ABILITY TO EXPAND OUR CAPACITY AND OFFERINGS THROUGH THE USE OF TELEHEALTH SERVICES. OHIOGUIDESTONE’S INTEGRATED SERVICES TREATMENT HELPS INDIVIDUALS SUFFERING FROM BOTH MENTAL HEALTH AND SUBSTANCE USE ISSUES SIMULTANEOUSLY. EVIDENCE-BASED TREATMENTS FOR THIS POPULATION INCLUDE COUNSELING, MEDICATION TREATMENTS, AND SUPPORTIVE SERVICES. SUD STAFF WILL COMPLETE A STANDARD DIAGNOSTIC EVALUATION WITH AN ASAM LEVEL ON EACH INDIVIDUAL, WHICH IS REQUIRED TO PROVIDE SUD SERVICES. SUD SERVICE PROGRESS IS MEASURED BY PATIENT REPORTED OUTCOME MEASURES (PROMS), BOTH SYMPTOMATIC AND FUNCTIONAL ON A MONTHLY BASIS.

AUGMENTED REALITY REAL-TIME GUIDANCE FOR MRI-GUIDED INTERVENTIONS - PROJECT SUMMARY THE OBJECTIVE OF THIS PROPOSAL IS TO MOVE INTO CLINICAL PRACTICE THE RESULT OF A PRECEDING PHASE I PROJECT, A COMPACT INSTRUMENT GUIDANCE SYSTEM THAT ALLOWS PHYSICIANS TO SEE INSTRUMENTS ADVANCING THROUGH AN MRI VOLUME WITHOUT UTILIZING SPECIAL NEEDLES, SPECIAL HEADGEAR OR CALIBRATION STEPS. MRI-GUIDANCE HAS BEEN USED FOR PERCUTANEOUS NEEDLE INJECTIONS TO DIAGNOSE AND TREAT NEUROPATHIC PAIN, PERFORM NEEDLE BIOPSY, DRAINAGE, TUMOR ABLATION, AND OTHER CLINICAL INDICATIONS. IN A PEDIATRIC SETTING, THERE IS A PREFERENCE FOR MR AND ULTRASOUND OVER CT AND X-RAY IMAGING BECAUSE NO IONIZING RADIATION IS EMITTED. FURTHER, MR IMAGES ARE BETTER FOR VISUALIZATION OF MSK SOFT TISSUE AND BONE LESIONS AND WOULD BE PREFERRED BY CLINICIANS BUT FOR THE LENGTH OF TIME TO PERFORM REAL-TIME NEEDLE INSERTIONS UNDER MR GUIDANCE, AND THE POOR ERGONOMICS OF IN-BORE INSERTIONS. ACCURATE AND RAPID DIAGNOSIS OF BONE TUMORS AND OTHER SUSPICIOUS BONE LESIONS IN CHILDREN IS ESSENTIAL TO APPROPRIATE CLINICAL MANAGEMENT. BONE BIOPSY PROCEDURES IN CHILDREN REQUIRE HIGHER TARGETING PRECISION AND ACCURACY DUE TO THEIR SMALLER SIZES. MRI-GUIDED BONE BIOPSY IS NOT ROUTINELY USED BECAUSE OF CURRENT LIMITATIONS IN TOOLS AND TECHNOLOGY. THE “ADVANCE AND CHECK” TECHNIQUE WHEREBY THE NEEDLE TRAJECTORY IS GUIDED/MONITORED BY INTERMEDIATE SCANS HAS BEEN TRANSLATED FROM THE CT ENVIRONMENT, BUT THIS TECHNIQUE WORKS WELL IN THE CT ENVIRONMENT BECAUSE OF QUICK IMAGE ACQUISITIONS AND SHORT SCANNER BORES. IT IS MUCH MORE TIME CONSUMING AND MUCH LESS CONVENIENT IN THE MRI ENVIRONMENT. THE OVERALL OBJECTIVE OF THIS PHASE II EFFORT IS TO ADAPT THE TECHNOLOGIES DEVELOPED IN THE PHASE I TO ASSIST CLINICIANS IN ACCURATE AND FAST IMAGE-GUIDED INSTRUMENT PLACEMENT WHEN USING ONLY MRI SCANS. THE PROPOSED NAVIGATION SYSTEM FOR MRI-GUIDED INTERVENTIONS WILL IMPROVE THE STANDARD OF CARE BY USING COMPUTER VISION AND HARDWARE ADVANCES TO BECOME A NEARLY HANDS-OFF COMPANION DEVICE TO THE OPERATOR, AUTOMATICALLY PERFORMING MANY STEPS WHICH CURRENTLY REQUIRE USER INPUT. THE LUMENA SYSTEM PROJECTS THE GUIDANCE FEEDBACK DIRECTLY ONTO THE INTERVENTION SITE AS WELL AS ON A MONITOR. THIS APPROACH ALLOWS THE INTERVENTIONALIST TO KEEP THEIR FOCUS ON THE INSERTION SITE INSTEAD OF THE MONITOR WHICH IS OFTEN NOT IN FRONT OF THEM. THE PROJECTED FEEDBACK IS SIMPLE TO FOLLOW AND CAN BE EASILY UNDERSTOOD WHICH MAKES THE SYSTEM INTUITIVE WITH ALMOST NO LEARNING CURVE. BY MAKING MRI-GUIDED BIOPSIES FASTER, THE SOCIETAL IMPACT OF THE DEVICE IS THAT IT WILL ALLOW MORE INTERVENTIONAL PROCEDURES TO BE PERFORMED UNDER MR-GUIDANCE, REDUCING IONIZING RADIATION FOR PATIENTS AND PHYSICIANS ALIKE.

ECONOMIC SPECTROSCOPIC EVALUATION OF CERVICAL CANCER

OHIOGUIDESTONE WORKFORCE SUPPORT PROGRAM

LOW COST IMAGE GUIDANCE FOR IMPROVED VESSEL CANNULATION IN PEDIATRIC PATIENTS

SEE NOTICE OF AWARD, ATTACHMENT 1 - TERMS AND CONDITIONS, ATTACHMENT D - STATEMENT OF WORK, ABSTRACT

STABLE TARGETING ASSISTANCE FOR ULTRASOUND-BASED INSTRUMENT GUIDANCE

UPDATING AND DISSEMINATING LEGS GOOD PRACTICE GUIDANCE

YOUTH BUILD

YOUTH BUILD

YOUTH BUILD

YOUTH BUILD

YOUTH BUILD

INSTACORTISOL: A REALTIME AND CONTINUOUS ASSESSMENT OF CORTISOL IN ISF

TAS::89 0321::TAS ADVANCED OPTICAL SENSORS TO MINIMIZE ENERGY CONSUMPTION IN POLYMER EXTRUSION PROCESSES

TUSCARAWAS COUNTY ANTI-DRUG COALITION

SBIR PHASE II: WEB ENABLED SYSTEM TO ASSESS, MENTOR AND ACCELERATE STARTUP BUSINESSES

MAXIMIZING THE NEW EDITION OF THE LIVESTOCK EMERGENCY GUIDELINES AND STANDARDS HANDBOOK THROUGH ENHANCED TRAINING AND DISSEMINATION OF GOOD PRACTICE GUIDANCE FOR THE DESIGN, IMPLEMENTATION, AND EVALUATION OF LIVESTOCK-BASED LIVELIHOODS RESPONSES IN EMERGENCIES THROUGH: UPDATING THE LIVESTOCK EMERGENCY GUIDELINES AND STANDARDS TRAINING RESOURCES TO BRING THEM INTO LINE WITH THE 3RD EDITION OF THE HANDBOOK, PROVIDING SUPPORT TO THE TRAINING PROGRAM AND TRAINERS, AND CONTINUED SUPPORT TO THE INSTITUTIONALIZATION AND LOCALIZATION OF THE THREE TARGET COUNTRIES AND GLOBALLY.

U.S. OFFSHORE WIND: REMOVING MARKET BARRIERS

U.S. OFFSHORE WIND: REMOVING MARKET BARRIERS

WOUNDED WARRIOR SERVICE DOG PROGRAM

A LOW-COST, PORTABLE GUIDANCE SYSTEM FOR NEEDLE BIOPSY

THE OBJECTIVE OF THIS PROJECT IS TO EXPAND THE TRIBE'S ENVIRONMENTAL PROTECTION PROGRAM TO INCLUDE INCREASING THE TRIBAL COMMUNITY'S KNOWLEDGE OF SO

THE OBJECTIVE OF THE PROJECT IS FOR GUIDIVILLE RANCHERIA TO PLAN, DEVELOP AND ESTABLISH THE CAPABILITY FOR DEVELOPING ENVIRONMENTAL PROTECTION PROGR

WORKFORCE DEVELOPMENT FOR HYDROPOWER

INSTITUTIONALIZING LEARNING INTO THE LEGS HANDBOOK AND TRAINING PROGRAM

GUIDEDOR: A REAL-TIME MEDICATION SAFETY SOFTWARE PLATFORM FOR THE OPERATING ROOM - GUIDEDOR: A REAL-TIME MEDICATION SAFETY SOFTWARE PLATFORM FOR THE OPERATING ROOM MEDICATION ADMINISTRATION IN THE OPERATING ROOM (OR) BYPASSES MANY OF THE STANDARD SAFETY CHECKS THAT EXIST THROUGHOUT THE REST OF THE HOSPITAL. FOR EXAMPLE, DUE TO THE FAST-PACED CLINICAL ENVIRONMENT, HIGH ACUITY AND RAPIDLY CHANGING PATIENT CONDITION IN THE OR, MEDICATIONS ARE TYPICALLY ADMINISTERED WITHOUT PROSPECTIVE MEDICATION ORDERS, DOUBLE-CHECKS BY SECOND PROVIDERS, OR ELECTRONIC CLINICAL DECISION SUPPORT TO WARN OF MEDICATION ERRORS. AS A RESULT, ABOUT 4-10% OF MEDICATION ADMINISTRATIONS, OR ALMOST EVERY SECOND OPERATION, INVOLVES A MEDICATION ERROR. ABOUT HALF OF THESE ERRORS LEAD TO OBSERVED PATIENT HARM, AND THE REMAINDER HAVE THE POTENTIAL FOR PATIENT HARM. THE COST OF THE HARM DUE TO ERRORS IS $5.3 BILLION ANNUALLY IN THE US ALONE, AND MORE THAN TWO-THIRDS OF THE HARM IS SERIOUS OR LIFE-THREATENING. GUIDEDOR IS A NOVEL OR CLINICAL DECISION SUPPORT SOFTWARE PLATFORM THAT IS INTEGRATED WITH THE ELECTRONIC HEALTH RECORD (EHR) AND USES REAL-TIME DATA TO DISPLAY PATIENT-SPECIFIC INFORMATION AND ALERTS ON THE OR COMPUTER MONITOR TO PREVENT ERRORS. BRIEFLY, THE BARCODE ON A MEDICATION SYRINGE LABEL IS SCANNED IMMEDIATELY PRIOR TO MEDICATION ADMINISTRATION. THE SCAN TRIGGERS GUIDEDOR TO DISPLAY A DOSING WINDOW CONTAINING THE DOSE, TIME ADMINISTERED, ROUTE, AND/OR ALERT(S) WHEN NECESSARY TO PREVENT A MEDICATION ERROR PRIOR TO THE MEDICATION BEING ADMINISTERED. THE CLINICIAN SIMPLY CONFIRMS THE DOSE OR ENTERS AN ALTERNATIVE DOSE IF NEEDED. AFTER THE MEDICATION PASSES THROUGH GUIDEDOR’S ALGORITHMS, THE MEDICATION DATA ARE SENT TO THE EHR IN REAL-TIME FOR AUTOMATED DOCUMENTATION. IN AN RCT, THE GUIDEDOR PROTOTYPE SUBSTANTIALLY OUTPERFORMED STANDARD MEDICATION USE WORKFLOWS BY IMPROVING CLINICIAN WORKFLOW EFFICIENCY (CLINICIANS SAVED > 20% OF THEIR TIME) AND QUALITY OF CARE METRICS INCLUDING TIGHTER BLOOD PRESSURE CONTROL, MORE ACCURATE MEDICATION DOSING AND BETTER PAIN MANAGEMENT. IN ADDITION, ON FIRST-TIME USE OF GUIDEDOR, CLINICIANS RATED ITS USABILITY DOUBLE THAT OF EXISTING EHRS. THROUGH ITERATIVE FEEDBACK SESSIONS WITH KEY CUSTOMER AND COMPANY STAKEHOLDERS, WE HAVE IDENTIFIED THE FOLLOWING ADDITIONAL CRITICAL FUNCTIONALITY THAT IS REQUIRED TO ACHIEVE COMMERCIALIZATION AND WIDESPREAD ADOPTION OF GUIDEDOR: SUPPORT FOR LOCAL ANESTHETIC SYSTEMIC TOXICITY, GLUCOSE MANAGEMENT AND PERIOPERATIVE ANTIBIOTIC MANAGEMENT. IN PHASE I OF THIS SBIR FAST-TRACK PROJECT, WE WILL IDENTIFY USER REQUIREMENTS AND FUNCTIONAL REQUIREMENTS FOR THIS CRITICAL NEW FUNCTIONALITY, AND DEPLOY THE NEW ALGORITHMS TO EPIC’S TESTING TOOL AT MASS GENERAL BRIGHAM. IN PHASE II, WE WILL ITERATIVELY IDENTIFY USABILITY CHALLENGES AND IMPLEMENT SOLUTIONS. WE WILL THEN PERFORM END-TO-END TESTING OF GUIDEDOR, INCLUDING BUILDING A NONINTERACTIVE “SILENT MODE” THAT WE WILL USE TO EVALUATE ALGORITHM BEHAVIOR IN LIVE SURGICAL CASES. WITH THE ADDITION OF THE PROPOSED CRITICAL FUNCTIONALITY, GUIDEDOR WILL TRANSFORM THE FIELD OF MEDICATION SAFETY, MAKING SURGERY AND ANESTHESIA SAFER FOR PATIENTS, MORE EFFICIENT FOR CLINICIANS, AND MORE COST-EFFECTIVE FOR HOSPITALS AND PAYORS.

ADDRESSING LUMBAR PUNCTURE CHALLENGES USING PATCH ULTRASOUND AND AUGMENTED REALITY - PROJECT SUMMARY EVERY YEAR, NEUROLOGISTS AND EMERGENCY PERSONNEL PERFORM OVER 400,000 DIAGNOSTIC AND THERAPEUTIC LUMBAR PUNCTURES (LP) TO COLLECT CEREBROSPINAL FLUID (CSF), A VITAL FLUID IN THE DIAGNOSIS AND TREATMENT OF A MYRIAD OF NEUROLOGICAL DISEASES AND DISORDERS. UNDER STANDARD CARE, LPS ARE PERFORMED IN AN INPATIENT ENVIRONMENT AT THE BEDSIDE. THE PROCEDURE INVOLVES NAVIGATING A NEEDLE THAT CAN BE UP TO 14 CM IN LENGTH INTO A 3-6 MM TARGET WINDOW IN THE LUMBAR SPINE REGION. PHYSICIANS FACE THE CHALLENGE OF PRECISE, ACCURATE NAVIGATION AND PLACEMENT OF THE NEEDLE TO THE TARGET. FAILURE TO COLLECT A VIABLE SAMPLE AND PROCEDURE-RELATED COMPLICATIONS CAN LEAD TO MISDIAGNOSES, TREATMENT DELAYS, AND UNNECESSARY AND EVEN DANGEROUS PROCEDURES. CURRENTLY, THE AVERAGE PHYSICIAN TAKES 3 ATTEMPTS TO CORRECTLY PLACE THE NEEDLE. THE ASSOCIATED FAILURE RATE OF THE PROCEDURE IS ~23.3%. THE FAILURE RATE RISES TO 50% IN OBESE AND SCOLIOTIC PATIENTS, FOR WHICH THE PHYSICIAN MUST NAVIGATE THROUGH EXCESS ADIPOSE TISSUE AND DIFFICULT ANATOMY. FAILURE TO COLLECT CSF LEADS THE USE OF FLUOROSCOPIC GUIDANCE, WHICH TAKES LONGER AND SUBJECTS THE PATIENT AND PHYSICIAN TO IONIZING RADIATION. EXCEPT FOR FLUOROSCOPIC GUIDANCE, THE CURRENT STANDARD OF CARE DOES NOT INVOLVE ANY VISUALIZATION OF TISSUE USING TECHNOLOGY SUCH AS TOPICAL ULTRASOUND. IN THIS PHASE I APPLICATION, WE PROPOSE A NAVIGATION SYSTEM FEATURING A PATIENT-ANCHORED ULTRASOUND PATCH WHICH TRANSFORMS LPS FROM A BLIND PROCEDURE WITH HIGH FAILURE RATE TO A FAST AND SIMPLE ONE. OUR SOLUTION ADDRESSES THE TYPICAL SHORTCOMINGS OF REGULAR ULTRASOUND GUIDANCE WHICH HAS LIMITED ITS WIDE ADOPTION FOR LPS. THE PATCH ULTRASOUND RELIEVES THE CLINICIAN FROM HANDLING THE ULTRASOUND AND NEEDLE SIMULTANEOUSLY, YIELDS HIGH-CONTRAST IMAGES OF THE VERTEBRAE PATHWAY, AND PROVIDES A RELIABLE 3D VOLUME. THE NAVIGATION SYSTEM WITH AUGMENTED REALITY HELPS THE CLINICIAN TO SUCCESSFULLY REACH THE TARGET ON THE FIRST TRY. MOST IMPORTANTLY, THE COMBINATION OF THESE TECHNOLOGIES OFFERS WHAT WE CALL ACTIVE NEEDLE VISUALIZATION, WHERE THE IMAGING PLANE OF THE ULTRASOUND IS CONTROLLED TO PROVIDE AN OPTIMAL VIEW OF THE NEEDLE IN A CLOSED-LOOP SYSTEM. OUR HYPOTHESIS IN THIS PROPOSAL IS THAT THE SIMPLICITY OF THE PATCH DESIGN AND THE AVAILABILITY OF OFF-THE-SHELF NAVIGATION COMPONENTS COMBINED WITH CLEAR GUIDE’S MATURED NAVIGATION PLATFORM PROMISES A COST-EFFECTIVE SOLUTION SUITABLE FOR THE CLINICAL APPLICATION AT HAND. WE WILL ACHIEVE OUR GOAL THROUGH THE FOLLOWING AIMS: (1) DEVELOP AND INTEGRATE PATIENT-ANCHORED ULTRASOUND IMAGING PATCH WITH CLEAR GUIDE MEDICAL TRACKING SYSTEM, (2) INTERFACE DESIGN AND INCORPORATION INTO A TABLET AND HEAD-MOUNTED DISPLAY (HMD), AND (3) ACCURACY MEASUREMENT AND USER DATA COLLECTION. THE ULTIMATE GOAL OF THIS ACADEMIC (JOHNS HOPKINS UNIVERSITY) AND INDUSTRY (CLEAR GUIDE MEDICAL) COLLABORATION IS THE SAFE, ECONOMIC, AND EFFECTIVE DEVELOPMENT OF PATIENT-ANCHORED ULTRASOUND PATCH TO ACTIVELY GUIDE LP PROCEDURES.

SBIR PHASE I: A NANO-OPTICAL IMAGING MICROENDOSCOPE FOR IN VIVO IMAGING -THE BROADER IMPACT/COMMERCIAL POTENTIAL OF THIS SMALL BUSINESS INNOVATION RESEARCH (SBIR) PHASE I PROJECT WILL ENABLE RESEARCHERS TO VISUALIZE THE DYNAMICS OF THE BIOLOGICAL EVENTS IN LIVE ANIMALS. THE PRODUCT, THE MINIATURIZED OPTICAL IMAGING MICRO-ENDOSCOPE, WILL CHANGE RESEARCHERS? CURRENT PARADIGM OF ONLY VISUALIZING AND EXPLORING THE SUPERFICIAL LAYERS OF TISSUE AT A SUBCELLULAR LEVEL. VISUALIZING THE DEEPER LAYERS OF TISSUE IN >1 MM DEPTH AT THE SUBCELLULAR LEVEL USING THE MINIATURIZED OPTICAL IMAGING MICRO-ENDOSCOPE WILL ENABLE A RANGE OF DISCOVERIES IN DIFFERENT AREAS OF BIOMEDICAL RESEARCH. IN THE LONG TERM, THE DEVELOPED PRODUCT CAN BE UTILIZED BY PHYSICIANS TO IMPROVE THE CURRENT STANDARDS OF CARE IN VARIOUS MEDICAL APPLICATIONS. THIS SMALL BUSINESS INNOVATION RESEARCH (SBIR) PHASE I PROJECT IS DEVELOPING A NANOPHOTONIC IMAGING MICROENDOSCOPE FOR IN VIVO IMAGING WITH MINIMAL DAMAGE. CURRENT OPTICAL MICROSCOPY IMAGING CANNOT BE USED FOR IMAGING BEYOND 1 MM DEPTH. THE CURRENT MICROENDOSCOPES HAVE A DIAMETER LARGER THAN 0.5-1 MM, SO THEY CAUSE SEVERE DAMAGE TO THE TISSUE WHEN INSERTED INTO THE TISSUE. THE CURRENT MICROENDOSCOPES CANNOT PROVIDE IMAGES IN >1 MM DEPTH SINCE THE DAMAGE TO THE TISSUE CHANGES THE WHOLE TISSUE STRUCTURE. MINIATURIZED MICROENDOSCOPIC TOOLS WITH SUBCELLULAR RESOLUTION ARE VITAL FOR DEEP TISSUE IMAGING (>1 MM). THE PRODUCT OF THIS SBIR PROJECT WILL BE 100 ?M DIAMETER, A HAIR-SIZE MICRO-ENDOSCOPE ALLOWING RESEARCHERS AND SCIENTISTS TO CONDUCT THEIR STUDIES AT >3 MM DEPTH IN A LIVE ANIMAL. THE STATE OF THE ART OF OPTICAL DESIGN AND NANOFABRICATION TECHNIQUES WILL BE UTILIZED TO MAKE THE MINIATURIZED MICROENDOSCOPE. THIS PROJECT WILL LEAD TO DERISKING THE RISKS ASSOCIATED WITH THE MINIATURIZATION OF THE OPTICAL MICROENDOSCOPE AND ENABLING ITS USAGE FOR IN VIVO IMAGING. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

A NOVEL DEVICE FOR TRAINING AND EVALUATING ULTRASOUND-GUIDED PROCEDURES IN ANESTHESIA - PROJECT SUMMARY THE USE OF ULTRASOUND FOR INTERVENTIONAL GUIDANCE HAS EXPANDED SIGNIFICANTLY OVER THE PAST DECADE AND HAS BECOME AN IMPORTANT TOOL IN CLINICAL SPECIALTIES SUCH AS ANESTHESIA, EMERGENCY MEDICINE AND SPORTS MEDICINE. IN INTERVENTIONAL ULTRASOUND, THERE ARE SIGNIFICANT CHALLENGES INTRODUCED BY THE NECESSITY OF SIMULTANEOUSLY VISUALIZING THE TARGET AND THE NEEDLE WITH A SINGLE B-MODE PROBE, KEEPING THE NONDOMINANT HAND STEADY WHILE FINDING THE CORRECT TRAJECTORY OF THE NEEDLE IN THE DOMINANT HAND. THE RESULTING ALIGNMENT PROBLEM (PROBE, INSTRUMENT, TARGET) IS A DIFFERENT SKILL PROBLEM THAN IDENTIFYING STRUCTURES IN ULTRASOUND AND REQUIRES SPECIALIZED TRAINING. CURRENT TRAINING SYSTEMS DO NOT PROVIDE SUITABLE INFORMATION TO AID THE NOVICE USER IN DEVELOPING KEY HAND-EYE COORDINATION SKILLS AND THEIR RETENTION. FOR THIS REASON, WE PROPOSE TO DESIGN THE EDU –COMPRISED OF AN INTERSON ULTRASOUND, A TABLET COMPUTER WITH GUIDANCE SOFTWARE, A CGM OPTICAL HEAD WITH TINY VIDEO CAMERAS, AND A CGM CUSTOM NERVE BLOCK PHANTOM-- AS A LEARNING PLATFORM FOR DEVELOPING KEY SKILLS IN NEEDLE ACQUISITION, ACCURACY OF NEEDLE PLACEMENT, AND UNDERSTANDING NEEDLE-TO-ULTRASOUND-PLANE ORIENTATION. THE USE OF TINY VIDEO CAMERAS ON THE ULTRASOUND ENABLE COMPUTER ALGORITHMS TO COMPUTE THE TRAJECTORY DIFFERENCES BETWEEN AN EXPERIENCED USER PERFORMING ONE OF THE REGIONAL BLOCKS AND A STUDENT’S ATTEMPT. THE DIFFERENCES BETWEEN THE PATHS TO THE TARGET ALLOW SOME QUANTIFICATION OF THE SKILLS, WHICH MAY BE HELPFUL IN GIVING FEEDBACK TO THE STUDENT DURING THE SEMESTER, AND PERHAPS ALSO TO DEVELOP A BENCHMARK FOR CME COURSES. A SECOND AIM OF THIS PROPOSAL IS TO STUDY WHETHER LEARNING WITH NEEDLE-GUIDANCE SOFTWARE IS BENEFICIAL TO STUDENT SKILL ACQUISITION AND/OR CONFIDENCE. THIS PROPOSAL WOULD STUDY A COHORT OF STUDENT REGISTERED NURSE ANESTHETISTS DURING A SEMESTER COURSE TEACHING FIVE PROGRESSIVELY MORE DIFFICULT NERVE BLOCKS/PROCEDURES. WITH THIS NOVEL SYSTEM, QUANTIFIABLE METRICS CAN BE HARNESSED TO DEMONSTRATE WHETHER LEARNING WITH GUIDANCE IS HELPFUL, EVEN WHEN THE GUIDANCE IS REMOVED, AND WHETHER IT CAN LEAD TO MORE CONSISTENT PROCEDURES ACROSS STUDENTS. USING PROPRIETARY CUSTOM- MADE PHANTOMS, THE PROGRESSIVE DIFFICULTY LEVELS OF THE FIVE PROCEDURES CAN SHOW WHETHER GUIDANCE CAN BE MORE HELPFUL IN MORE DIFFICULT BLOCS OR IF IT CAN HELP IN ALL.

AN AUGMENTED REALITY DEVICE TO PREVENT WRONG-LEVEL SPINE SURGERY

AUGMENTED REALITY REAL-TIME GUIDANCE FOR MRI INTERVENTIONS

PROJECT PREVAIL YOUTH COALITION FOR SUBSTANCE USE PREVENTION - THE MISSION OF THE PROJECT PREVAIL YOUTH COALITION PPYC IS TO EMPOWER YOUTH AGES 12 - 18 LIVING IN VARIOUS ZIP CODES WITHIN WILMINGTON DE TO PREVENT AND/OR REDUCE HARMFUL USE OF PRESCRIPTION DRUGS, MARIJUANA AND TOBACCO/VAPING PRODUCT USE. THE PPYC WILL COMPLETE ITS MISSION THROUGH EDUCATION, ADVOCACY AND COLLABORATIVE EFFORTS WHILE RAISING AWARENESS, PROMOTING HEALTHY LIFESTYLES AND PROVIDING SUPPORT TO YOUTH THAT ARE AFFECTED. OUR ACTIVITIES AND EFFORTS WILL BE BASED ON PROVEN EVIDENCE-BASED STRATEGIES THAT WILL FOSTER A STRONG YOUTH PREVENTION COALITION FOR YEARS TO COME.

TUSCARAWAS COUNTY ANTI-DRUG COALITION

TABLET-BASED AUGMENTED REALITY FOR FAST CT GUIDANCE WITH REDUCED RADIATION

WOUNDED WARRIOR SERVICE DOG PROGRAM

** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** LAND ACCESS IS A FUNDAMENTAL, OFTEN INSURMOUNTABLE, CHALLENGE IN OUR FOOD SYSTEM THAT PREVENTS NEW AND BEGINNING FARMERS FROM ACHIEVING VIABLE CAREERS IN AGRICULTURE. THIS CHALLENGE PERVADES COLORADO, BUT IS PARTICULARLY STARK FOR RURAL, UNDER-RESOURCED, SOCIALLY DISADVANTAGED, AND VETERAN COMMUNITIES. THIS PROJECT SEEKS TO BUILD ON GUIDESTONE'S VIBRANT, STATEWIDE, LAND LINK PROGRAM BY TAPPING INTO REGIONAL LAND TRUSTS TO CREATE A MORE ROBUST NETWORK OF LAND ACCESS OPPORTUNITIES WHILE SIMULTANEOUSLY WORKING WITH EXPERT PARTNERS TO REACH, EDUCATE, SUPPORT, AND ELEVATE UNDERSERVED BEGINNING FARMERS AND RANCHERS AROUND THE STATE. WE AIM TO CONCRETELY BENEFIT NEW AND BEGINNING FARMERS AND RANCHERS BY (1) IMPROVING THE REACH, QUALITY AND ACCESSIBILITY OF OUR EDUCATIONAL RESOURCES, (2) WORKING CLOSELY WITH AG LANDOWNERS TO BUILD OPPORTUNITIES, (3) HOSTING A VARIETY OF AUDIENCE TAILORED LAND ACCESS WORKSHOPS WITH OUR PARTNERS, AND (4) ELEVATING THE STORIES, NEEDS, AND EXPERIENCES OF NEW AND UNDERSERVED PRODUCERS BY CREATING SPACE FOR THEM TO DELIVER PRESENTATION AND WORKSHOPS TO THE AGRICULTURE COMMUNITY. WE BELIEVE THAT THIS PROJECT CAPITALIZES ON THE MOMENTUM AND SYNERGY OF THE LAND ACCESS WORK BEING DONE IN COLORADO, AND WILL HELP TO CRYSTALIZE A ROBUST AND EQUITABLE AGRICULTURAL FUTURE IN OUR COMMUNITIES.

SBIR PHASE I: WEB ENABLED EXPERT SYSTEM TO SCALE DIAGNOSIS AND IMPROVEMENT OF ENTREPRENEURIAL SKILLS

SMALL BUSINESS-ERC COLLABORATIVE OPPORTUNITY: IN-SITU INFORMATION DISPLAY FOR ULTRASOUND GUIDED INTERVENTIONS

INSTACORTISOL:A REALTIME AND CONTINUOUS ASSESSMENT OF CORTISOL IN ISF

IN-SITU GUIDANCE FOR ULTRASOUND NEEDLE-BASED INTERVENTIONS

WOUNDED WARRIOR SERVICE DOG PROGRAM

THE PURPOSE OF THIS AGREEMENT IS TO ENGAGE 1,000 VOLUNTEERS IN A SUBSTANTIAL REFORESTATION PROJECT, ENHANCING U.S. PARTNERSHIP AND CROATIA'S REGIONAL LEADERSHIP IN CLIMATE ACTIONS.

WOUNDED WARRIOR SERVICE DOG PROGRAM WWSD

FARM TO SCHOOL GRANT PROGRAM

COMMUNITY FACILITY GRANTS

COMMUNITY FACILITIES - ECONOMIC IMPACT INITIATIVE GRANTS

THE FUNDING REQUEST IS FOR THE IMPLEMENTATION OF SUPPORT GROUPS, HIV RELATED HOME SERVICES AND TARGETED PREVENTION ACTIVITIES.

THIS GRANT WILL FUND SUPPORT GROUPS, ADHERENCE CLUBS AND COMMUNITY-BASED HIV TESTING AND COUNSELING SERVICES.

SUSAN HARWOOD GRANTS

THE OVERALL GOAL OF "SECURING A FUTURE ON THE LAND" IS TO CONNECT BEGINNING FARMERS AND RANCHERS (BFRS) TO LAND ACCESS OPTIONS IN COLORADO AND PREPARE THEM FOR SECURE LAND TENURE TO SUPPORT A DIVERSE AGRICULTURAL FUTURE. THERE ARE FOUR OBJECTIVES FOR THIS GOAL: 1) INCREASE THE POOL OF CERTIFIED LAND ACCESS TRAINERS (LATS) BY COMPLETING AMERICAN FARMLAND TRUST'S SELF-PACED PROGRAM, 2) IMPROVE AND EXPAND BFRS KNOWLEDGE OF LAND TENURE OPTIONS AND HOW TO EXECUTE SECURE LAND TRANSFER AGREEMENTS BY OFFERING LAT COURSES IN VARIOUS FORMATS TO INCREASE PARTICIPATION, 3) IMPROVE LAND OWNER KNOWLEDGE OF BFR'S LAND ACCESS ISSUES AND RECRUIT MORE LANDOWNERS/RETIRINGFARMERS AND RANCHERS TO THE COLORADO LAND LINK DATABASE, 4) ESTABLISH A CRITERIA SYSTEM FOR EVALUATION OF LAND MATCHES EACH YEAR.OUR PLANS TO ACCOMPLISH THE PROJECT GOALS INCLUDE: FULFILLING THE CRITERIA FOR THE LAT CERTIFICATION; PARTNERING WITH GROUPS AND INDIVIUDALS TO ENHANCE OUR RECRUITMENT OF BFRS; PROVIDING STIPENDS TO ALL BFRS WHO ATTEND OUR LAT COURSES; DELIVERING COURSES VIRTUALLY AND IN-PERSON; WORKING WITH LAND TRUSTS TO ESTABLISH RELATIONSHIPS WITH LANDOWNERS TO INCREASE THE NUMBER OF VIABLE LAND LISTINGS IN THE DATABASE; DEVELOPING A LAND ACCESS ADVISORY TEAM; INTERVIEWING BEGINNING AND RETIRING FARMERS/RANCHERS TO DETERMINE KNOWLEDGE GAPS; RESEARCH OF EVALUATION SYSTEMS AND METRICS OF LAND MATCHES.THIS PROJECT MEETS THE GOALS OF THE BFRDP BY PROVIDING INNOVATIVE LAND TRANSFER AND SUCCESSION STRATEGIES, AS WELL AS TECHNICAL ASSSITANCE TO HELP BFRS ACQUIRE LAND FROM RETIRING FARMERS/RANCHERS.

LONG-TERM MONITORING OF CRITICAL CAMPING BEACHES IN THE GRAND CANYON THROUGH THE ADOPT-A-BEACH PROGR

ELDERLY TAX OUTREACH

COMMUNITY FACILITY GRANTS

USGS NON-COMPETITIVE ASSISTANCE FY 2021 - SACRAMENTO ACQUISITION BRANCH

GRAND CANYON RIVER GUIDES - MONITORING CRITICAL CAMPING BEACHES

ADOPT-A-BEACH PROGRAM

LONG-TERM MONITORING OF CRITICAL CAMPING BEACHES IN THE GRAND CANYON THROUGH THE ADOPT-A-BEACH

HSNG COUNSEL ADMIN CONT SERVIC

HOUSING COUNSELING ASSISTANCE PROGRAM

HOUSING COUNSELING ASSISTANCE PROGRAM

THIS GRANT WILL FUND THE IMPLEMENTATION OF TARGETED PREVENTION INTERVENTIONS THROUGH YOLO FOR 1000 ADOLESCENTS AND YOUNG PEOPLE AND CHOMMY FOR 1000 ADOLESCENTS.

NATIVE AMERICAN LIBRARY SERVICES

SEC 9007 REAP-RENEW ENERGY SYSTEMS GRANTS, $20,000 OR LESS (MAN)

LETZEBUERGER GUIDEN A SCOUTEN IS AWARDED A GRANT TO SUPPORT THEIR IRONSCOUT 2025 PROGRAM, WHICH WILL FOCUS ON "REMEMBRANCE OF WWII" AND INCLUDE KEY WWII MONUMENTS, PLAQUES, AND A VISIT TO THE NATIONAL MILITARY HISTORY MUSEUM.

NATIVE AMERICAN LIBRARY SERVICES

NATIVE AMERICAN LIBRARY SERVICES

NATIVE AMERICAN LIBRARY SERVICES

COMMUNITY FACILITY GRANTS

NATIVE AMERICAN LIBRARY SERVICES

NATIVE AMERICAN LIBRARY SERVICES

SEC 9007 REAP-RENEW ENERGY SYSTEMS GRANTS, $20,000 OR LESS (MAN)

HOUSING COUNSELING ASSISTANCE PROGRAM

U.S. OFFSHORE WIND: REMOVING MARKET BARRIERS

COMMUNITY FACILITY GRANTS

DOMESTIC WATER GRANTS - REGULAR

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