Population Council Inc

TO PROVIDE INCREMENTAL FUNDING IN THE AMOUNT OF $2,000,000.

DIVERSIFICATION OF FAMILY PLANNING ACTIVITIES IN PAKISTAN (DFPAP)

APP FOR AAD 936-3090

LEADING: LICENSURE AND ENSURING ACCESS TO THE DAPIVIRINE RING (DAPIVRINE RING LAUNCH PROGRAM)

PRH/RTU IMPLEMENTATION SCIENCE FOR STRENGTHENING USE OF EVIDENCE (ISSUE)

BREAKTHROUGH RESEARCH

MICROBICIDES APS ROUND 2

DELIVERING A FAMILY OF CONTRACEPTIVE VAGINAL RINGS

COOPORATIVE CONTRACEPTIVE RESEARCH CENTER

THIS IS A FOLLOW-ON NEW SOLE SOURCE COOPERAIVE AGREEMENT TO POPULATION COUNCIL TO IMPLIMENT A PROGRAM CALLED HIV PREVENTION FOR VULNERABLE ADOLECENT

CONTRACEPTION DEVELOPMENT RESEARCH CENTER TO ADVANCE A NOVEL INTRAVAGINAL RING AS A NON-HORMONAL MULTIPURPOSE PREVENTION TECHNOLOGY - OVERALL – ABSTRACT THE OVERARCHING GOAL OF THE POPULATION COUNCIL’S (PC) P50 PROPOSAL IS TO DEVELOP AN INNOVATIVE NON-HORMONAL MULTIPURPOSE PREVENTION TECHNOLOGY (MPT) INTRAVAGINAL RING (IVR) WITH THE POTENTIAL TO IMPROVE THE LIVES OF MILLIONS OF WOMEN GLOBALLY BY COMBATTING THE OVERLAPPING BURDENS OF UNINTENDED PREGNANCY AND SEXUALLY TRANSMITTED INFECTIONS (STIS), INCLUDING HIV. EMERGING DATA INDICATE THAT WOMEN OVERWHELMINGLY PREFER PRODUCTS THAT PREVENT PREGNANCY AND STIS/HIV OVER ONES THAT PREVENT ONLY PREGNANCY OR ONLY STI/HIVS. OUR ‘CZL-IVR’ IS A USER-CONTROLLED 30-DAY IVR CONTAINING THREE ACTIVE PHARMACEUTICAL INGREDIENTS (APIS), COPPER (C), ZINC ACETATE (Z), AND LACTIDE (L) (A LACTIC ACID PRODRUG) THAT TOGETHER HAVE NON-HORMONAL CONTRACEPTIVE AND ANTI-STI/HIV ACTIVITY INCLUDING CHLAMYDIA (CT), GONORRHEA (GC), HSV-2, AND HIV-1. LACTIDE MAINTAINS OPTIMAL VAGINAL PH AND PROVIDES ANTIBACTERIAL, ANTIVIRAL, AND ANTI-BACTERIAL VAGINOSIS (BV) EFFECTS. WE WILL ADVANCE DEVELOPMENT OF OUR CZL-IVR THROUGH IMPLEMENTATION OF THREE INTEGRATED RESEARCH PROJECTS. IN PROJECT 1 WE AIM TO FORMULATE AND MANUFACTURE CZL-IVRS THAT ACHIEVE 30-DAY API DELIVERY, MANUFACTURE AND CHARACTERIZE IN VITRO MECHANICAL PERFORMANCE OF IVRS WITH VARYING DIMENSIONS AND POLYMERS WITH THE SELECTION OF FOUR CANDIDATES WITH A RANGE OF MECHANICAL CHARACTERISTICS TO EVALUATE IN END-USER RESEARCH, AND ESTABLISH GOOD MANUFACTURING PRACTICE (GMP) PRODUCTION FOR NON-MEDICATED RINGS FOR RESEARCH CONDUCTED IN PROJECT 3. IN PROJECT 2 WE AIM TO DEFINE THE OPTIMAL API DELIVERY DOSES OF THE THREE APIS ALONE AND IN COMBINATION, AND TO CONFIRM THE EFFICACY AND SAFETY OF THE PROTOTYPE CZL-IVR BY CONDUCTING ESSENTIAL PRECLINICAL STUDIES INCLUDING IN-VITRO AND IN-VIVO CONTRACEPTIVE EFFICACY AND ANTIMICROBIAL EFFICACY AND TOXICITY STUDIES OF APIS AND OF PROTOTYPE HUMAN-SIZED AND RHESUS MACAQUE-SIZED CZL- IVRS. IN PROJECT 3 WE WILL INFORM CZL-IVR DEVELOPMENT AND THE FIELD MORE BROADLY THROUGH END-USER RESEARCH EMPLOYING NOVEL MIXED METHOD APPROACHES INCLUDING A CONTROLLED SETTING CROSS-OVER STUDY OF THE FOUR SELECTED CANDIDATE NON-MEDICATED IVRS OF VARYING MECHANICAL CHARACTERISTICS, A 30-DAY CONTINUOUS USE STUDY OF A NON- MEDICATED PROTOTYPE IVR WITH AN EMBEDDED TEMPERATURE SENSOR, AND A NATIONAL CROSS-SECTIONAL SURVEY WITH A DISCRETE CHOICE EXPERIMENT (DCE) AND LATENT CLASS ANALYSIS (LCA). THE ADMINISTRATIVE CORE WILL SUPPORT AND SYNERGIZE OUR INTERDISCIPLINARY COLLABORATIVE RESEARCH, PROVIDE SCIENTIFIC, ADMINISTRATIVE, AND OPERATIONAL EXPERTISE AND OVERSIGHT, AND MANAGE ADVISORY COMMITTEES TO ENSURE ADHERENCE TO TIMELINES AND SUCCESS IN ACHIEVING OUR AIMS THROUGH RIGOROUS SCIENCE. OUR P50 CENTER WILL BE A HUB FOSTERING CAREERS OF EARLY STAGE INVESTIGATORS AND INSPIRING MPT PRODUCT DEVELOPMENT THROUGH FELLOWSHIPS AND PILOT PROJECT GRANTS. DRAWING FROM OUR WORLD-CLASS CENTER FOR BIOMEDICAL RESEARCH AND BUILDING ON DECADES OF SUCCESSFUL CONTRACEPTIVE PRODUCT DEVELOPMENT, THE PC’S P50 CENTER WILL CAPITALIZE ON THE RICH, COLLABORATIVE, AND INTERDISCIPLINARY ENVIRONMENT AND THE VAST EXPERIENCE OF THE PC AND OUR PARTNERS TO ADVANCE DEVELOPMENT OF AN INNOVATIVE MPT PRODUCT.

POSTABORTION CARE AND FAMILY PLANNING

COMMUNITY BASED HEALTH PLANNING AND SERVICES

MODULATING MUCOSAL DCS AND T CELLS TO LIMIT SIV SPREAD

SUPPORT AIDS POPULATION AND HEALTH INTEGRATED ASSISTANCE PROGRAM (APHIA II) OPERATIONS RESEARCH PROJECT IN KENYA. THIS IS A THREE-YEAR COOPERATIVE AG

TO NEGOTIATE AND AWARD A COOPERATIVE AGREEMENT TO SUPPORT THE DEVELOPMENT IMPLEMENTATION AND SCALING-UP OF COMMUNITY-BASED AGREEMENTS TO DECREASE H

THIS MOD ADDS INCREMENTAL FUNDINGS IN THE AMOUNT OF $1,520,000.00

AN ETONOGESTREL/ETHINYL ESTRADIOL/QGRIFFITHSIN (ETG/EE/QGRFT) IVR TO PREVENT PREGNANCY AND HIV

IMPROVING ACCESS AND DELIVERY OF COMPREHENSIVE POST-EXPOSURE PROPHYLAXIS (PEP) FOR SEXUAL ASSAULT (ADULTS AND CHILDREN) AND OCCUPATIONAL PEP THROUGH

NOVEL PRE-COITAL, NON-HORMONAL MULTIPURPOSE PREVENTION TECHNOLOGY (MPT)

PRH/RTU-SSR OBJECTIVE 1 - POP COUNCIL

"IMPLEMENTATION OF PROGRAMS FOR PREVENTION, CARE AND TREATMENT OF HIV/AIDS IN THE

ROLE OF INTEGRINS IN HIV/SIV TRANSMISSION ACROSS CERVICO-VAGINAL MUCOSA

FORMATIVE ASSESSMENT, SIZE ESTIMATION AND INTEGRATED BIOLOGICAL AND BEHAVIORAL SU

HIV PREVENTION AND CARE SERVICES FOR YOUNG PEOPLE IN KENYA

THE BIOLOGY OF BLOOD-TESTIS BARRIER DYNAMICS

EFFECT OF SEX HORMONES ON HIV INFECTION OF CERVICAL AND RECTAL MUCOSAL TISSUE

POPULATION COUNCIL PROPOSES TO USE IDR TO COMBAT FORCED BEGGING OF PEOPLE WITH DISABILITIES (PWD) IN ADDIS ABABA, TIGRAY, AND AMHARA, ETHIOPIA.

SUPPORTING STRATEGIC PROGRAMMING FOR KEY AND PRIORITY POPULATIONS IN UGANDA THROUGH ENHANCED USE OF DATA

INCREMENTAL FUNDING AMOUNT OF $386,000.

ZCM: A NOVEL BROAD-SPECTRUM MICROBICIDE FOR STIS

EDUCATION AND HIV RISK AMONG YOUNG PEOPLE IN A HIGH PREVALENCE COUNTRY

HIV-ENVELOPE-SPECIFIC DARPIN-BASED MICROBICIDE STRATEGIES

PRH/RTU-SSR OBJECTIVE 3 - POP COUNCIL

MODULATING MUCOSAL DCS AND T CELLS TO LIMIT SIV SPREAD

SCALING UP POSSIBLE SEVERE BACTERIAL INFECTION (PSBI) GUIDELINES IN KENYA

SYYPE 2022 WILL EXAMINE HOW THE LIVES OF THE YOUNG PEOPLE INTERVIEWED IN THE FIRST ROUND OF SYPE 2009 (WHEN THEY WERE AGED 10-29 YEARS) AND RE-INTERVIEWED IN 2014 (WHEN THEY WERE AGED 14-34 YEAR) HAVE CONTINUED TO EVOLVE. THE COHORT IS NOW AGED 22-42 YEARS AND WILL LIKELY HAVE STARTED THEIR OWN FAMILIES. THE MAJORITY WILL HAVE COMPLETED THEIR EDUCATION AND ARE EXPECTED TO BE CONTRIBUTING ECONOMICALLY TO EGYPT. THE THREE MAIN GOALS OF SYPE 2022 ARE: 1. UNDERSTAND THE EFFECTS OF REFORMS AND EVENTS ON VARIOUS GROUPS OF YOUNG PEOPLE; 2. ASSESS THE CURRENT SITUATION OF YOUNG PEOPLE AGED 10-29 WITH REGARD TO HEALTH, EDUCATION, EMPLOYMENT, MARRIAGE AND FAMILY FORMATION, GENDER ATTITUDES, COVID-19, CLIMATE CHANGE; AND, 3. UNDERSTAND TRANSITIONS TO ADULTHOOD AMONGST YOUNG PEOPLE WITH PHYSICAL DISABILITIES AND CHALLENGES AND OPPORTUNITIES THEY HAVE TO FULFILL THEIR FULL POTENTIAL.

IMPACT OF ART ON DC AND TEG RESPONSES IN ORAL TISSUES

EVALUATION OF A PROGESTERONE VAGINAL RING AS A NEW CONTRACEPTIVE OPTION IN INDIA

IN SEARCH OF STEM LEYDIG CELLS: IDENTIFICATION, ISOLATION & DEVELOPMENT

AGING AND FUNCTION OF STEM LEYDING CELLS

ROLE OF INTEGRIN A4B7 IN HIV/SIV TRANSMISSION ACROSS CERVICO-VAGINAL MUCOSA

SURVEY OF YOUNG PEOPLE IN EGYPT

COMBINING PREP WITH CONTRACEPTION: A PILOT TEST OF AN INTERVENTION TO INCREASE ADHERENCE TO PREP IN ADOLESCENT GIRLS AND YOUNG WOMEN IN ZIMBABWE

PARTNERSHIP FOR DEVELOPING BROAD-SPECTRUM MICROBICIDES

PRH/RTU-BIO: POP COUNCIL REGULATORY APPROVAL OF MPTS

A NOVEL VAGINAL RING TO PREVENT HIV AND HSV-2 INFECTION, AS WELL AS PREGNANCY

ASSESSING & IMPROVING THE MEASUREMENT OF SEXUAL BEHAVIOR

ASSESSING WILLINGNESS TO PARTICIPATE AND METHODS FOR IMPROVING ADHERENCE AND SELF

ASSESSING THE ACCEPTABILITY, FEASIBILITY, AND A POTENTIAL DISTRIBUTION MODEL OF HIV ORAL SELF-TESTING (HST) AMONG MEN WHO HAVE SEX WITH MEN (MSM) IN

MATERNAL CHILD HEALTH AAD

ISOLATION AND PROTEOMIC ANALYSIS OF THE SPERM ANNULUS

BIOLOGY OF DESMOSOME-GAP JUNCTIONS IN THE TESTIS

INTEGRATING 30 YEARS OF SETTLEMENT-LEVEL CENSUS DATA FOR INDIA

ACADEMIC SKILLS AND REPRODUCTIVE BEHAVIOR AMONG ADOLESCENT GIRLS.

ARE IMPROVEMENTS IN SENESCENT LIFE EXPECTANCY ACCELERATING OR DECELERATING?

GH11-1169: FORMATIVE ASSESSMENT, SIZE ESTIMATION AND INTEGRATED BIOLOGICAL AND BEHAVIORAL SU