Raf Inc

THE DELICIOUS DECARBONIZATION THROUGH INTEGRATED ELECTRIFICATION AND ENERGY STORAGE PROJECT, LED BY KRAFT HEINZ, PLANS TO UPGRADE, ELECTRIFY, AND DECARBONIZE ITS PROCESS HEAT AT 10 FACILITIES BY APPLYING A RANGE OF TECHNOLOGIES INCLUDING HEAT PUMPS, ELECTRIC HEATERS, AND ELECTRIC BOILERS IN COMBINATION WITH BIOGAS BOILERS, SOLAR THERMAL, SOLAR PHOTOVOLTAIC, AND THERMAL ENERGY STORAGE. THE TAILORED APPLICATION OF THESE TECHNOLOGIES AT EACH FACILITY EXPECTS TO REDUCE ANNUAL EMISSIONS BY MORE THAN 300,000 METRIC TONS OF CARBON DIOXIDE PER YEAR, TRANSLATING TO A 99% REDUCTION FROM 2022 LEVELS. BY DEMONSTRATING THE INTEGRATION OF MULTIPLE DECARBONIZATION PATHWAYS, THIS PROJECT SEEKS TO HELP A MAJOR AMERICAN BRAND ACHIEVE DEEP DECARBONIZATION AND SERVE AS AN EXAMPLE FOR OTHER U.S. FOOD AND BEVERAGE COMPANIES TO REDUCE EMISSIONS FROM PROCESS HEAT WHILE REDUCING ENERGY COSTS. THIS PROJECT EXPECTS TO CREATE AN ESTIMATED 500 CONSTRUCTION JOBS ACROSS THE 10 SITES. THREE OF THE 10 PROJECT SITES (FREMONT, OH; HOLLAND, MI; AND MUSCATINE, IA) CURRENTLY HAVE UNIONIZED LABOR. ALL SITES HAVE PEOPLE COMMITTEES AS PART OF THE KRAFT HEINZ MANAGEMENT SYSTEM THAT INCLUDES HOURLY AND SALARIED EMPLOYEE REPRESENTATIVES INCLUDING HUMAN RESOURCES. AN ENERGY CHAMPION WILL JOIN THE COMMITTEE TO REPRESENT ANY WORKER CONCERNS AND SERVE AS COORDINATOR BETWEEN THE PROJECT TEAM AND PLANT WORKERS. KRAFT HEINZ ANTICIPATES THE IMPLEMENTATION OF NEW TECHNOLOGIES WOULD REQUIRE ADDITIONAL TRAINING AND SKILLS FOR EMPLOYEES AT EACH SITE. MANY OF THE PLANTS HAVE DEVELOPED PARTNERSHIPS WITH COMMUNITY SCHOOLS TO FURTHER TRAIN AND DEVELOP PLANT EMPLOYEES.

JOINT MULTI-ROLE TECHNOLOGY DEMONSTRATOR PHASE I AIR VEHICLE DEVELOPMENT

JOINT MULTI-ROLE TECHNOLOGY DEMONSTRATOR PHASE I AIR VEHICLE DEVELOPMENT

BIPARTISAN INFRASTRUCTURE LAW (BIL): LARGE SCALE MANUFACTURING OF HIGH-PERFORMANCE SILICON MONOXIDE ANODE MATERIALS THE OBJECTIVE OF THE PROJECT IS COMPLETELY RETROFIT AN EXISTING STRUCTURE FOR THE ESTABLISHMENT OF A STATE-OF-THE-ART SILICON MONOXIDE (SIO) ANODE MANUFACTURING FACILITY, DIRECTLY ADDRESSING THE CRITICAL NEED FOR DOMESTIC BATTERY MATERIAL MANUFACTURING. THE PROJECT WILL TARGET A PRODUCTION OUTPUT OF 2,500 TONS PER YEAR AND 11 GWH OF ANODE CAPACITY. IN ALIGNMENT WITH THE DEPARTMENT OF ENERGY’S (DOE) OBJECTIVES, THE PROJECT IS EXPECTED TO STRENGTHEN THE DOMESTIC BATTERY SUPPLY CHAIN, ENHANCE NATIONAL SECURITY, AND GALVANIZE EMPLOYMENT IN ITS SURROUNDING DISADVANTAGED COMMUNITIES.

ADVANCED ALCOHOL DETECTION TECHNOLOGY

COOPERATIVE AGREEMENT FOR DRIVER ALCOHOL DETECTION SYSTEM FOR SAFETY PROGRAM

JOINT MULTI-ROLE TECHNOLOGY DEMONSTRATOR PHASE I AIR VEHICLE DEVELOPMENT

SECTION 164 TRANSFER PROGRAM: REPEAT INTOXICATED DRIVER (23 C.F.R. PART 1275; 23 U.S.C. § 164) ― PENALTY TRANSFER FUNDS TO SUPPORT ALCOHOL AND DRUG-IMPAIRED DRIVING COUNTERMEASURES IN STATES THAT FAIL TO ENACT AND ENFORCE CONFORMING REPEAT ALCOHOL-INTOXICATED DRIVER LAWS. UNDER SECTION 164, TO AVOID THE TRANSFER OF FUNDS, A STATE MUST ENACT AND ENFORCE A REPEAT INTOXICATED DRIVER LAW THAT ESTABLISHES, AT MINIMUM, CERTAIN SPECIFIED PENALTIES FOR SECOND AND SUBSEQUENT CONVICTIONS OF DRIVING WHILE INTOXICATED OR DRIVING UNDER THE INFLUENCE. 23 U.S.C. 164(A)(5).

SECTION 164 TRANSFER PROGRAM: REPEAT INTOXICATED DRIVER (23 C.F.R. PART 1275; 23 U.S.C. § 164) €• PENALTY TRANSFER FUNDS TO SUPPORT ALCOHOL AND DRUG-IMPAIRED DRIVING COUNTERMEASURES IN STATES THAT FAIL TO ENACT AND ENFORCE CONFORMING REPEAT ALCOHOL-INTOXICATED DRIVER LAWS. UNDER SECTION 164, TO AVOID THE TRANSFER OF FUNDS, A STATE MUST ENACT AND ENFORCE A REPEAT INTOXICATED DRIVER LAW THAT ESTABLISHES, AT MINIMUM, CERTAIN SPECIFIED PENALTIES FOR SECOND AND SUBSEQUENT CONVICTIONS OF DRIVING WHILE INTOXICATED OR DRIVING UNDER THE INFLUENCE. 23 U.S.C. 164(A)(5).

SECTION 164 TRANSFER PROGRAM: REPEAT INTOXICATED DRIVER (23 C.F.R. PART 1275; 23 U.S.C. % 164) - PENALTY TRANSFER FUNDS TO SUPPORT ALCOHOL-IMPAIRED DRIVING COUNTERMEASURES IN STATES THAT FAIL TO ENACT AND ENFORCE CONFORMING REPEAT INTOXICATED DRIVER LAWS.

AL-BIL 164 TRANSFER FUNDS

SECTION 164 TRANSFER PROGRAM: REPEAT INTOXICATED DRIVER (23 C.F.R. PART 1275; 23 U.S.C. & 164) - PENALTY TRANSFER FUNDS TO SUPPORT ALCOHOL-IMPAIRED DRIVING COUNTERMEASURES IN STATES THAT FAIL TO ENACT AND ENFORCE CONFORMING REPEAT INTOXICATED DRIVER LAWS.

164 TRANSFER FUNDS

SECTION 164 REPEAT INTOXICATED DRIVER LAWS PENALTY TRANSFER FUNDS

SECTION 402 STATE AND COMMUNITY HIGHWAY SAFETY GRANT (23 C.F.R. SUBPART B TO PART 1300; 23 U.S.C. § 402) €• GRANT TO CONDUCT HIGHWAY SAFETY PROGRAMS UNDER THE STATE€™S APPROVED HIGHWAY SAFETY PLAN.SECTION 402 FUNDING FACILITATES A COORDINATED NATIONAL HIGHWAY SAFETY PROGRAM TO REDUCE TRAFFIC CRASHES, DEATHS, INJURIES, AND PROPERTY DAMAGE. A STATE MAY USE THESE GRANT FUNDS ONLY FOR BEHAVIORAL HIGHWAY SAFETY PURPOSES. THESE FUNDS ARE APPORTIONED USING STATUTORY APPORTIONMENT FORMULA. THESE FUNDS ARE PROVIDED TO THE STATE AND TERRITORIAL HIGHWAY SAFETY OFFICES BASED ON AN APPROVED TRIENNIAL HIGHWAY SAFETY PLAN THAT DETAILS PROBLEM IDENTIFICATION, PUBLIC PARTICIPATION AND ENGAGEMENT, PERFORMANCE MEASURES, COUNTERMEASURE STRATEGIES FOR PROGRAMMING FUNDS AND AN APPROVED ANNUAL GRANT APPLICATION THAT DETAILS PLANNED PROJECTS USING IDENTIFIED COUNTERMEASURE STRATEGIES FOR PROGRAMMING FUNDS TO HELP REDUCE CRASHES, INJURIES AND FATALITIES RESULTING FROM MOTOR VEHICLE CRASHES.

SECTION 402 STATE AND COMMUNITY HIGHWAY SAFETY GRANT (23 C.F.R. SUBPART B TO PART 1300; 23 U.S.C. & 402) - GRANT TO CONDUCT HIGHWAY SAFETY PROGRAMS UNDER THE STATE'S APPROVED HIGHWAY SAFETY PLAN.

SECTION 164 REPEAT INTOXICATED DRIVER LAWS PENALTY TRANSFER FUNDS

SECTION 402 STATE AND COMMUNITY HIGHWAY SAFETY GRANT (23 C.F.R. SUBPART B TO PART 1300; 23 U.S.C. § 402) ― GRANT TO CONDUCT HIGHWAY SAFETY PROGRAMS UNDER THE STATE’S APPROVED HIGHWAY SAFETY PLAN.SECTION 402 FUNDING FACILITATES A COORDINATED NATIONAL HIGHWAY SAFETY PROGRAM TO REDUCE TRAFFIC CRASHES, DEATHS, INJURIES, AND PROPERTY DAMAGE. A STATE MAY USE THESE GRANT FUNDS ONLY FOR BEHAVIORAL HIGHWAY SAFETY PURPOSES. THESE FUNDS ARE APPORTIONED USING STATUTORY APPORTIONMENT FORMULA. THESE FUNDS ARE PROVIDED TO THE STATE AND TERRITORIAL HIGHWAY SAFETY OFFICES BASED ON AN APPROVED TRIENNIAL HIGHWAY SAFETY PLAN THAT DETAILS PROBLEM IDENTIFICATION, PUBLIC PARTICIPATION AND ENGAGEMENT, PERFORMANCE MEASURES, COUNTERMEASURE STRATEGIES FOR PROGRAMMING FUNDS AND AN APPROVED ANNUAL GRANT APPLICATION THAT DETAILS PLANNED PROJECTS USING IDENTIFIED COUNTERMEASURE STRATEGIES FOR PROGRAMMING FUNDS TO HELP REDUCE CRASHES, INJURIES AND FATALITIES RESULTING FROM MOTOR VEHICLE CRASHES.

SECTION 164 REPEAT INTOXICATED DRIVER LAWS PENALTY TRANSFER FUNDS

SECTION 164 REPEAT INTOXICATED DRIVER LAWS PENALTY TRANSFER FUNDS

SECTION 164 REPEAT INTOXICATED DRIVER LAWS PENALTY TRANSFER FUNDS

SECTION 402 STATE AND COMMUNITY HIGHWAY SAFETY GRANT

SECTION 164 REPEAT INTOXICATED DRIVER LAWS PENALTY TRANSFER FUNDS

SECTION 402 STATE AND COMMUNITY HIGHWAY SAFETY GRANT (23 C.F.R. SUBPART B TO PART 1300; 23 U.S.C. & 402) - GRANT TO CONDUCT HIGHWAY SAFETY PROGRAMS UNDER THE STATE'S APPROVED TRIENNIAL HIGHWAY SAFETY PLAN. SECTION 402 FUNDING FACILITATES A COORDINATED NATIONAL HIGHWAY SAFETY PROGRAM TO REDUCE TRAFFIC CRASHES, DEATHS, INJURIES, AND PROPERTY DAMAGE. A STATE MAY USE THESE GRANT FUNDS ONLY FOR BEHAVIORAL HIGHWAY SAFETY PURPOSES. THESE FUNDS ARE APPORTIONED USING STATUTORY APPORTIONMENT FORMULA. THESE FUNDS ARE PROVIDED TO THE STATE AND TERRITORIAL HIGHWAY SAFETY OFFICES BASED ON AN APPROVED TRIENNIAL HIGHWAY SAFETY PLAN THAT DETAILS PROBLEM IDENTIFICATION, PUBLIC PARTICIPATION AND ENGAGEMENT, PERFORMANCE MEASURES, COUNTERMEASURE STRATEGIES FOR PROGRAMMING FUNDS AND AN APPROVED ANNUAL GRANT APPLICATION THAT DETAILS PLANNED PROJECTS USING IDENTIFIED COUNTERMEASURE STRATEGIES FOR PROGRAMMING FUNDS TO HELP REDUCE CRASHES, INJURIES AND FATALITIES RESULTING FROM MOTOR VEHICLE CRASHES.

164 TRANSFER FUNDS

ALLOCATION TO ALOCHOL TRANSFER PROGRAM

MINIMUM PENALTIES FOR REPEAT OFFENDERS FOR DWI TRANSFER PROGRAM

SECTION 402 STATE AND COMMUNITY HIGHWAY SAFETY GRANT

SECTION 402 STATE AND COMMUNITY HIGHWAY SAFETY GRANT

STATE AND COMMUNITY HIGHWAY SAFETY

STATE AND COMMUNITY HIGHWAY SAFETY

SECTION 402 STATE AND COMMUNITY HIGHWAY

SECTION 402 STATE AND COMMUNITY HIGHWAY

MISSION SYSTEMS DEVELOPMENT AND INTEGRATION FOR ADVANCED TEAMING DEMONSTRATION PROGRAM

STATE AND COMMUNITY HIGHWAY SAFETY PROGRAM SEC 402 ¿¿ 20.600

SECTION 402 STATE AND COMMUNITY HIGHWAY

SECTION 402 STATE AND COMMUNITY HIGHWAY

SECTION 402 STATE AND COMMUNITY HIGHWAY

HEAD START: FULL YEAR PART DAY HANDICAPPED TRAINING AND TECHNICAL ASSISTANCE

HEAD START AND EARLY HEAD START

SCHOOLCRAFT COLLEGE CARES (INSTITUTIONAL FUNDING)

HEAD START AND EARLY HEAD START

HEAD START-FULL YEAR/PART DAY

SECTION 405(D) IMPAIRED DRIVING COUNTERMEASURES GRANT (23 C.F.R. § 1300.23; 23 U.S.C. § 405(D)) ― GRANT TO SUPPORT CERTAIN COSTS OF STATE IMPAIRED DRIVING COUNTERMEASURES PROGRAMS CONSISTENT WITH 23 C.F.R. § 1300.23(J). 405(D) FUNDING IS USED FOR IMPAIRED DRIVING COUNTERMEASURES. QUALIFYING STATES MUST MEET STATUTORY REQUIREMENTS AND CAN ALSO RECEIVE FUNDING FOR ADOPTION AND ENFORCEMENT A MANDATORY ALCOHOL-IGNITION INTERLOCK LAWS AND 24/7 SOBRIETY PROGRAMS. THESE FUNDS ARE APPORTIONED USING STATUTORY APPORTIONMENT FORMULA. THESE FUNDS ARE PROVIDED TO THE STATE AND TERRITORIAL HIGHWAY SAFETY OFFICES BASED ON AN APPROVED TRIENNIAL HIGHWAY SAFETY PLAN THAT DETAILS PROBLEM IDENTIFICATION, PUBLIC PARTICIPATION AND ENGAGEMENT, PERFORMANCE MEASURES, COUNTERMEASURE STRATEGIES FOR PROGRAMMING FUNDS AND AN APPROVED ANNUAL GRANT APPLICATION THAT DETAILS PLANNED PROJECTS USING IDENTIFIED COUNTERMEASURE STRATEGIES FOR PROGRAMMING FUNDS TO HELP REDUCE CRASHES, INJURIES AND FATALITIES RESULTING FROM MOTOR VEHICLE CRASHES.

SECTION 405(D) IMPAIRED DRIVING COUNTERMEASURES GRANT (23 C.F.R. § 1300.23; 23 U.S.C. § 405(D)) €• GRANT TO SUPPORT CERTAIN COSTS OF STATE IMPAIRED DRIVING COUNTERMEASURES PROGRAMS CONSISTENT WITH 23 C.F.R. § 1300.23(J). 405(D) FUNDING IS USED FOR IMPAIRED DRIVING COUNTERMEASURES. QUALIFYING STATES MUST MEET STATUTORY REQUIREMENTS AND CAN ALSO RECEIVE FUNDING FOR ADOPTION AND ENFORCEMENT A MANDATORY ALCOHOL-IGNITION INTERLOCK LAWS AND 24/7 SOBRIETY PROGRAMS. THESE FUNDS ARE APPORTIONED USING STATUTORY APPORTIONMENT FORMULA. THESE FUNDS ARE PROVIDED TO THE STATE AND TERRITORIAL HIGHWAY SAFETY OFFICES BASED ON AN APPROVED TRIENNIAL HIGHWAY SAFETY PLAN THAT DETAILS PROBLEM IDENTIFICATION, PUBLIC PARTICIPATION AND ENGAGEMENT, PERFORMANCE MEASURES, COUNTERMEASURE STRATEGIES FOR PROGRAMMING FUNDS AND AN APPROVED ANNUAL GRANT APPLICATION THAT DETAILS PLANNED PROJECTS USING IDENTIFIED COUNTERMEASURE STRATEGIES FOR PROGRAMMING FUNDS TO HELP REDUCE CRASHES, INJURIES AND FATALITIES RESULTING FROM MOTOR VEHICLE CRASHES.

HEAD START AND EARLY HEAD START

SECTION 405(D) IMPAIRED DRIVING COUNTERMEASURES GRANT (23 C.F.R. & 1300.23; 23 U.S.C. & 405(D)) - GRANT TO SUPPORT CERTAIN COSTS OF STATE ALCOHOL-IMPAIRED DRIVING PROGRAMS CONSISTENT WITH 23 C.F.R. & 1300.23(J).

SECTION 405(D) IMPAIRED DRIVING COUNTERMEASURES GRANT

COMBAT TEMPERED PLATFORM DEMONSTRATION

CAPABILITY-BASED OPERATIONS SUSTAINMENT TECHNOLOGY AVIATION

SCHOOLCRAFT COLLEGE CARES STUDENT RELIEF PROGRAM

SECTION 405(D) IMPAIRED DRIVING COUNTERMEASURES GRANT

SECTION 405(D) IMPAIRED DRIVING COUNTERMEASURES GRANT

SECTION 405(D) IMPAIRED DRIVING COUNTERMEASURES GRANT (23 C.F.R. § 1300.23; 23 U.S.C. § 405(D)) ― GRANT TO SUPPORT CERTAIN COSTS OF STATE ALCOHOL-IMPAIRED DRIVING PROGRAMS CONSISTENT WITH 23 C.F.R. § 1300.23(J).

SECTION 405(D) IMPAIRED DRIVING COUNTERMEASURES

HEAD START

SECTION 405(D) IMPAIRED DRIVING COUNTERMEASURES

SECTION 405(D) IMPAIRED DRIVING COUNTERMEASURES

SECTION 405(D) IMPAIRED DRIVING COUNTERMEASURES

SECTION 405(D) IMPAIRED DRIVING COUNTERMEASURES

SECTION 405(D) IMPAIRED DRIVING COUNTERMEASURES

SECTION 405(D) IMPAIRED DRIVING COUNTERMEASURES

SECTION 402 STATE AND COMMUNITY HIGHWAY SAFETY GRANTS

SECTION 402 STATE AND COMMUNITY HIGHWAY

PURPOSE: THE PROPOSED PROJECT WILL DEVELOP THE 222-MILE COUNTY OF GRAFTON MIDDLE-MILE BACKBONE NETWORK THROUGH POPULATION CENTERS THROUGH A COMBINATION OF BUILDING NEW FIBER OPTIC CABLE WHERE THERE ARE OBVIOUS GAPS AND OPTIMIZING EXISTING INFRASTRUCTURE WHERE POSSIBLE, REDUCING COSTS OF THE BUILDOUT. THE BACKBONE WILL BE AVAILABLE FOR MUNICIPALITIES TO THEN TAP INTO AND RUN ADDITIONAL FIBER OPTIC CABLE THROUGH THEIR MUNICIPALITIES TO REACH THE LAST MILE. THE NETWORK WILL PROVIDE THE ELECTRONICS AND OPTICS NECESSARY TO PROVIDE SERVICE AT IDENTIFIED MUNICIPAL/COUNTY ANCHOR LOCATIONS AND WILL ALLOW FOR FUTURE GROWTH AND EXPANSION WITH MINIMAL ADDITIONAL EQUIPMENT. THE NON-MUNICIPAL/COUNTY LOCATIONS WILL BE SERVED THROUGH DARK FIBER ACCESS ONLY, ALLOWING ISPS TO MAKE THEIR OWN INVESTMENTS WITHIN INDIVIDUAL COMMUNITIES. THE RURAL NATURE OF THE REGION, PAIRED WITH THE FACT THAT THERE ARE LESS THAN 53 PERSONS PER SQUARE MILE, PREVENTS PRIVATE INTERNET SERVICE PROVIDERS FROM MAKING THE SIGNIFICANT UPFRONT INVESTMENT TO DEVELOP A MIDDLE-MILE OR LAST MILE BROADBAND NETWORK. BY CENTRALIZING THE MIDDLE MILE BACKBONE, A GREAT NUMBER OF INDIVIDUALS WILL BE SERVED WITHIN A SHORT TIME FRAME, BRINGING SPEEDS OF UP TO 1 GBPS TO THE REGION. THE PROJECT WILL ENCOURAGE THE EXPANSION OF MIDDLE MILE INFRASTRUCTURE TO REDUCE THE COST OF CONNECTING UNSERVED AND UNDERSERVED AREAS TO THE BACKBONE OF THE INTERNET AND WILL PROMOTE BROADBAND CONNECTION RESILIENCY THROUGH THE CREATION OF ALTERNATIVE NETWORK CONNECTION PATHS THAT ARE DESIGNED TO PREVENT SINGLE POINTS OF FAILURE ON THE BROADBAND NETWORK.ACTIVITIES TO BE PERFORMED AND EXPECTED OUTCOMES: (1.) DEPLOY A COUNTYWIDE OPEN-ACCESS, MIDDLE-MILE, FIBER-OPTIC NETWORK THROUGHOUT THE COUNTY WITH DARK FIBER ACCESS SERVICE.(2.) FACILITATE INTERCONNECTIONS TO DARTMOUTH COLLEGE AND THE UNIVERSITY OF NEW HAMPSHIRE TO SUPPORT EDUCATION AS WELL AS PROVIDE ADDITIONAL REDUNDANCY AND NETWORK RESILIENCY.(3.) SERVE ALL THE MUNICIPALITIES WITHIN THE COUNTY WITH A DARK FIBER BACKBONE THAT IS CAPABLE OF SUPPORTING LAST MILE SPEEDS WITH A MINIMUM OF 100MBPS UP TO A 1GBPS TO HOMES AND BUSINESSES.INTENDED BENEFICIARIES: WITHIN THE PROJECT AREA, THERE ARE AN ESTIMATED 6,100 HOUSEHOLDS CONSIDERED UNSERVED BY NTIA DEFINITION (12% OF THE TOTAL). ACCORDING TO BROADBANDNOW.COM/NEW-HAMPSHIRE, OF THE 10 COUNTIES IN THE STATE, GRAFTON COUNTY IS RANKED AS THE 4TH COUNTY IN THE STATE WITH THE LEAST AVAILABILITY OF 100 MBPS BROADBAND SERVICE THIS PROJECT WILL POISE THE REGION TO DELIVER CRITICAL BROADBAND SERVICES TO THESE HOUSEHOLDS.WITHIN THE COUNTY THERE ARE 27 K-12 EDUCATION FACILITIES, 41 LICENSED CHILDCARE FACILITIES, 5 HIGHER-EDUCATION INSTITUTIONS, 2 CAREER TECHNOLOGY CENTERS, AND 5 HOSPITALS. THE BUILDOUT OF THE MIDDLE-MILE GRAFTON COUNTY BROADBAND NETWORK WILL ALLOW THESE ANCHOR INSTITUTIONS TO ACCESS AFFORDABLE, HIGH-SPEED INTERNET SERVICES TO SUPPORT THEIR RESIDENTS AND WORKFORCE.THIS NETWORK INFRASTRUCTURE WILL PROVIDE THE COUNTY, ITS RESIDENTS, AND BUSINESSES THE OPPORTUNITY TO ASCERTAIN QUALITY BROADBAND SERVICES AT LEVELS THAT DO NOT EXIST TODAY. THE EXPANSION OF RELIABLE, MODERN FIBER-OPTIC BROADBAND INFRASTRUCTURE WITHIN THE REGION WILL SPUR ECONOMIC DEVELOPMENT AND PROVIDE THE COUNTY THE SCALABILITY FOR FUTURE SERVICES, INCLUDING PUBLIC SAFETY, EDUCATION, HEALTHCARE AND OTHER GOVERNMENT SERVICES.SUBRECIPIENT ACTIVITIES: DESIGN, PERMITTING, MAKE-READY, CONSTRUCTION/CONSTRUCTION MANAGEMENT, AND MIDDLE MILE NETWORK MANAGEMENT ACTIVITIES WILL BE SUB-AWARDED TO EX2 TECHNOLOGY LLC.

SECTION 410 ALCOHOL SAFETEA-LU

SECTION 410 ALCOHOL SAFETEA-LU

AIRCRAFT AND AIRCREW PROTECTION - PHASE I

AUTONOMOUS SUSTAINMENT TECHNOLOGIES FOR ROTORCRAFT OPERATIONS TECHNICAL AREA: PROPULSION

ROTORCRAFT DRIVE TRAIN SYSTEM

REDUCING OPPORTUNITIES FOR UNLAWFUL TRANSPORT OF ENDANGERED SPECIES (ROUTES)

HEAD START AND EARLY HEAD START

FUTURE ADVANCED ROTORCRAFT DRIVE SYSTEM

HEAD START AND EARLY HEAD START

ROTARY WING STRUCTURES TECHNOLOGY DEMONSTRATION

SECTION 402 STATE AND COMMUNITY HIGHWAY SAFETY GRANT (23 C.F.R. SUBPART B TO PART 1300; 23 U.S.C. § 402) €• GRANT TO CONDUCT HIGHWAY SAFETY PROGRAMS UNDER THE STATE€™S APPROVED HIGHWAY SAFETY PLAN.SECTION 402 FUNDING FACILITATES A COORDINATED NATIONAL HIGHWAY SAFETY PROGRAM TO REDUCE TRAFFIC CRASHES, DEATHS, INJURIES, AND PROPERTY DAMAGE. A STATE MAY USE THESE GRANT FUNDS ONLY FOR BEHAVIORAL HIGHWAY SAFETY PURPOSES. THESE FUNDS ARE APPORTIONED USING STATUTORY APPORTIONMENT FORMULA. THESE FUNDS ARE PROVIDED TO THE STATE AND TERRITORIAL HIGHWAY SAFETY OFFICES BASED ON AN APPROVED TRIENNIAL HIGHWAY SAFETY PLAN THAT DETAILS PROBLEM IDENTIFICATION, PUBLIC PARTICIPATION AND ENGAGEMENT, PERFORMANCE MEASURES, COUNTERMEASURE STRATEGIES FOR PROGRAMMING FUNDS AND AN APPROVED ANNUAL GRANT APPLICATION THAT DETAILS PLANNED PROJECTS USING IDENTIFIED COUNTERMEASURE STRATEGIES FOR PROGRAMMING FUNDS TO HELP REDUCE CRASHES, INJURIES AND FATALITIES RESULTING FROM MOTOR VEHICLE CRASHES.

SECTION 402 STATE AND COMMUNITY HIGHWAY SAFETY GRANT (23 C.F.R. SUBPART B TO PART 1300; 23 U.S.C. & 402) - GRANT TO CONDUCT HIGHWAY SAFETY PROGRAMS UNDER THE STATE'S APPROVED HIGHWAY SAFETY PLAN.

HIGH SPEED, HIGHLY EFFICIENT ROTOR PROGRAM

SECTION 402 STATE AND COMMUNITY HIGHWAY SAFETY GRANT (23 C.F.R. SUBPART B TO PART 1300; 23 U.S.C. § 402) ― GRANT TO CONDUCT HIGHWAY SAFETY PROGRAMS UNDER THE STATE’S APPROVED HIGHWAY SAFETY PLAN.SECTION 402 FUNDING FACILITATES A COORDINATED NATIONAL HIGHWAY SAFETY PROGRAM TO REDUCE TRAFFIC CRASHES, DEATHS, INJURIES, AND PROPERTY DAMAGE. A STATE MAY USE THESE GRANT FUNDS ONLY FOR BEHAVIORAL HIGHWAY SAFETY PURPOSES. THESE FUNDS ARE APPORTIONED USING STATUTORY APPORTIONMENT FORMULA. THESE FUNDS ARE PROVIDED TO THE STATE AND TERRITORIAL HIGHWAY SAFETY OFFICES BASED ON AN APPROVED TRIENNIAL HIGHWAY SAFETY PLAN THAT DETAILS PROBLEM IDENTIFICATION, PUBLIC PARTICIPATION AND ENGAGEMENT, PERFORMANCE MEASURES, COUNTERMEASURE STRATEGIES FOR PROGRAMMING FUNDS AND AN APPROVED ANNUAL GRANT APPLICATION THAT DETAILS PLANNED PROJECTS USING IDENTIFIED COUNTERMEASURE STRATEGIES FOR PROGRAMMING FUNDS TO HELP REDUCE CRASHES, INJURIES AND FATALITIES RESULTING FROM MOTOR VEHICLE CRASHES.

SECTION 402 STATE AND COMMUNITY HIGHWAY SAFETY GRANT

SECTION 402 STATE AND COMMUNITY HIGHWAY SAFETY GRANT (23 C.F.R. SUBPART B TO PART 1300; 23 U.S.C. & 402) - GRANT TO CONDUCT HIGHWAY SAFETY PROGRAMS UNDER THE STATE'S APPROVED TRIENNIAL HIGHWAY SAFETY PLAN. SECTION 402 FUNDING FACILITATES A COORDINATED NATIONAL HIGHWAY SAFETY PROGRAM TO REDUCE TRAFFIC CRASHES, DEATHS, INJURIES, AND PROPERTY DAMAGE. A STATE MAY USE THESE GRANT FUNDS ONLY FOR BEHAVIORAL HIGHWAY SAFETY PURPOSES. THESE FUNDS ARE APPORTIONED USING STATUTORY APPORTIONMENT FORMULA. THESE FUNDS ARE PROVIDED TO THE STATE AND TERRITORIAL HIGHWAY SAFETY OFFICES BASED ON AN APPROVED TRIENNIAL HIGHWAY SAFETY PLAN THAT DETAILS PROBLEM IDENTIFICATION, PUBLIC PARTICIPATION AND ENGAGEMENT, PERFORMANCE MEASURES, COUNTERMEASURE STRATEGIES FOR PROGRAMMING FUNDS AND AN APPROVED ANNUAL GRANT APPLICATION THAT DETAILS PLANNED PROJECTS USING IDENTIFIED COUNTERMEASURE STRATEGIES FOR PROGRAMMING FUNDS TO HELP REDUCE CRASHES, INJURIES AND FATALITIES RESULTING FROM MOTOR VEHICLE CRASHES.

SECTION 402 STATE AND COMMUNITY HIGHWAY SAFETY GRANTS

ADAPTIVE RESILIENT ENGINEERED STRUCTURES

GREEN AND RESILIENT RETROFIT PROGRAM

SECTION 402 STATE AND COMMUNITY HIGHWAY SAFETY GRANT

SECTION 405 OCCUPANT PROTECTION INCENTIV

SECTION 402 STATE AND COMMUNITY HIGHWAY SAFETY GRANT

STATE AND COMMUNITY HIGHWAY SAFETY

SECTION 164 REPEAT INTOXICATED DRIVER LAWS PENALTY TRANSFER FUNDS

SECTION 405 OCCUPANT PROTECTION INCENTIV

STATE AND COMMUNITY HIGHWAY SAFETY

SECTION 402 STATE AND COMMUNITY HIGHWAY

IND ENABLING DEVELOPMENT OF CF-296, A LYSIN FOR THE TREATMENT OF INVASIVE STAPHYLOCOCCUS AUREUS (S. AUREUS) INFECTIONS

SECTION 402 STATE AND COMMUNITY HIGHWAY

SECTION 405(D) IMPAIRED DRIVING COUNTERMEASURES GRANT (23 C.F.R. & 1300.23; 23 U.S.C. & 405(D)) - GRANT TO SUPPORT CERTAIN COSTS OF STATE ALCOHOL-IMPAIRED DRIVING PROGRAMS CONSISTENT WITH 23 C.F.R. & 1300.23(J). 405(D) FUNDING IS USED FOR IMPAIRED DRIVING COUNTERMEASURES. QUALIFYING STATES MUST MEET STATUTORY REQUIREMENTS AND CAN ALSO RECEIVE FUNDING FOR ADOPTION AND ENFORCEMENT A MANDATORY ALCOHOL-IGNITION INTERLOCK LAWS AND 24/7 SOBRIETY PROGRAMS. THESE FUNDS ARE APPORTIONED USING STATUTORY APPORTIONMENT FORMULA. THESE FUNDS ARE PROVIDED TO THE STATE AND TERRITORIAL HIGHWAY SAFETY OFFICES BASED ON AN APPROVED TRIENNIAL HIGHWAY SAFETY PLAN THAT DETAILS PROBLEM IDENTIFICATION, PUBLIC PARTICIPATION AND ENGAGEMENT, PERFORMANCE MEASURES, COUNTERMEASURE STRATEGIES FOR PROGRAMMING FUNDS AND AN APPROVED ANNUAL GRANT APPLICATION THAT DETAILS PLANNED PROJECTS USING IDENTIFIED COUNTERMEASURE STRATEGIES FOR PROGRAMMING FUNDS TO HELP REDUCE CRASHES, INJURIES AND FATALITIES RESULTING FROM MOTOR VEHICLE CRASHES.

ECONOMIC DEVELOPMENT INITIATIVE, COMMUNITY PROJECT FUNDING, AND MISCELLANEOUS GRANTS

SECTION 405(C) STATE TRAFFIC SAFETY INFORMATION SYSTEMS

PURPOSE: TO PROVIDE GRANTS TO COMMUNITY DEVELOPMENT FINANCIAL INSTITUTIONS (CDFIS) FOR THE FOLLOWING PURPOSES 1) TO EXPAND LENDING, GRANT MAKING AND INVESTMENT ACTIVITIES IN LOW OR MODERATE INCOME COMMUNITIES AND TO BORROWERS THAT HAVE HISTORICALLY EXPERIENCED SIGNIFICANT UNMET CAPITAL AND FINANCIAL SERVICES NEEDS AND WERE DISPROPORTIONATELY IMPACTED BY THE COVID 19 PANDEMIC; AND 2) TO ENABLE CDFIS TO BUILD ORGANIZATIONAL CAPACITY AND ACQUIRE TECHNOLOGY, STAFF, AND OTHER TOOLS NECESSARY TO ACCOMPLISH THE ACTIVITIES UNDER A CDFI ERP AWARD. PLANNED ACTIVITIES: ELIGIBLE ACTIVITIES INCLUDE FINANCIAL PRODUCTS, FINANCIAL SERVICES, DEVELOPMENT SERVICES, GRANTS, LOAN LOSS RESERVES AND CAPITAL RESERVES THAT MAY BE USED TO MITIGATE THE IMPACT OF THE COVID 19 PANDEMIC ON UNEMPLOYMENT, CHILDCARE, HEALTHCARE, MENTAL HEALTHCARE, AFFORDABLE HOUSING, AFFORDABLE HOUSING FINANCE, SMALL BUSINESS, SMALL FARMS, BROADBAND INTERNET, AND FOOD SUFFICIENCY. IN ADDITION, TO SUPPORT CDFIS IN BUILDING THEIR CAPACITY TO RESPOND TO THE ECONOMIC IMPACT OF COVID 19, CDFI ERP AWARDS MAY BE USED FOR COMPENSATION PERSONAL SERVICES; COMPENSATION FRINGE BENEFITS; PROFESSIONAL SERVICE COSTS; TRAVEL COSTS; TRAINING AND EDUCATION COSTS; EQUIPMENT; SUPPLIES. END GOALS: EXPANDED FINANCING FOR LOW TO MODERATE INCOME COMMUNITIES AND INDIVIDUALS THAT HAVE HISTORICALLY EXPERIENCED SIGNIFICANT UNMET CAPITAL AND FINANCIAL SERVICES NEEDS AND WERE DISPROPORTIONATELY IMPACTED BY THE COVID 19 PANDEMIC INCLUDING SPECIFIC DESIGNATED COVID IMPACTED CDFI ERP ELIGIBLE GEOGRAPHIES AS AREAS THAT MAY BENEFIT FROM CDFI ERP ASSISTANCE. BENEFICIARIES: CERTIFIED CDFIS WHICH MAY BE FOR PROFIT ORGANIZATION, PRIVATE NONPROFIT INSTITUTION/ORGANIZATION, AND OTHER PRIVATE INSTITUTION/ORGANIZATION, AS DEFINED IN 12 C.F.R. 1805, AND LOW AND MODERATE INCOME INDIVIDUALS AND FAMILIES. SUBRECIPIENTS: THERE ARE NO SUBRECIPIENTS FOR THIS PROGRAM. BROADBAND: SPECIFIC ACTIVITIES RELATING TO BROADBAND USAGE ARE NOT KNOWN AT THE TIME OF AWARD. REASON/PURPOSE OF MODIFICATION: NOT APPLICABLE.

PURPOSE: TO PROVIDE GRANTS TO COMMUNITY DEVELOPMENT FINANCIAL INSTITUTIONS (CDFIS) FOR THE FOLLOWING PURPOSES 1) TO EXPAND LENDING, GRANT MAKING AND INVESTMENT ACTIVITIES IN LOW OR MODERATE INCOME COMMUNITIES AND TO BORROWERS THAT HAVE HISTORICALLY EXPERIENCED SIGNIFICANT UNMET CAPITAL AND FINANCIAL SERVICES NEEDS AND WERE DISPROPORTIONATELY IMPACTED BY THE COVID 19 PANDEMIC; AND 2) TO ENABLE CDFIS TO BUILD ORGANIZATIONAL CAPACITY AND ACQUIRE TECHNOLOGY, STAFF, AND OTHER TOOLS NECESSARY TO ACCOMPLISH THE ACTIVITIES UNDER A CDFI ERP AWARD. PLANNED ACTIVITIES: ELIGIBLE ACTIVITIES INCLUDE FINANCIAL PRODUCTS, FINANCIAL SERVICES, DEVELOPMENT SERVICES, GRANTS, LOAN LOSS RESERVES AND CAPITAL RESERVES THAT MAY BE USED TO MITIGATE THE IMPACT OF THE COVID 19 PANDEMIC ON UNEMPLOYMENT, CHILDCARE, HEALTHCARE, MENTAL HEALTHCARE, AFFORDABLE HOUSING, AFFORDABLE HOUSING FINANCE, SMALL BUSINESS, SMALL FARMS, BROADBAND INTERNET, AND FOOD SUFFICIENCY. IN ADDITION, TO SUPPORT CDFIS IN BUILDING THEIR CAPACITY TO RESPOND TO THE ECONOMIC IMPACT OF COVID 19, CDFI ERP AWARDS MAY BE USED FOR COMPENSATION PERSONAL SERVICES; COMPENSATION FRINGE BENEFITS; PROFESSIONAL SERVICE COSTS; TRAVEL COSTS; TRAINING AND EDUCATION COSTS; EQUIPMENT; SUPPLIES. END GOALS: EXPANDED FINANCING FOR LOW TO MODERATE INCOME COMMUNITIES AND INDIVIDUALS THAT HAVE HISTORICALLY EXPERIENCED SIGNIFICANT UNMET CAPITAL AND FINANCIAL SERVICES NEEDS AND WERE DISPROPORTIONATELY IMPACTED BY THE COVID 19 PANDEMIC INCLUDING SPECIFIC DESIGNATED COVID IMPACTED CDFI ERP ELIGIBLE GEOGRAPHIES AS AREAS THAT MAY BENEFIT FROM CDFI ERP ASSISTANCE. BENEFICIARIES: CERTIFIED CDFIS WHICH MAY BE FOR PROFIT ORGANIZATION, PRIVATE NONPROFIT INSTITUTION/ORGANIZATION, AND OTHER PRIVATE INSTITUTION/ORGANIZATION, AS DEFINED IN 12 C.F.R. 1805, AND LOW AND MODERATE INCOME INDIVIDUALS AND FAMILIES. SUBRECIPIENTS: THERE ARE NO SUBRECIPIENTS FOR THIS PROGRAM. BROADBAND: SPECIFIC ACTIVITIES RELATING TO BROADBAND USAGE ARE NOT KNOWN AT THE TIME OF AWARD. REASON/PURPOSE OF MODIFICATION: NOT APPLICABLE.

TO AWARD COOPERATIVE AGREEMENT TO INDUSTREE CRAFTS FOUNDATION TO PROVIDE SUPPORT FOR THE ¿PRODUCER OWNED WOMEN ENTREPRENEURS (POWER)¿

SECTION 410 ALCOHOL TRAFFIC SAFETY AND DRUNK DRIVING PREVENTION INCENTIVE GRANTS

SECTION 405(C) STATE TRAFFIC SAFETY INFORMATION SYSTEM IMPROVEMENTS GRANT (23 C.F.R. § 1300.22; 23 U.S.C. § 405(C)) €• GRANT TO SUPPORT DATA PROGRAM IMPROVEMENTS IN THE ACCURACY, COMPLETENESS, TIMELINESS, UNIFORMITY, ACCESSIBILITY, OR INTEGRATION OF CORE HIGHWAY SAFETY DATABASES CONSISTENT WITH 23 C.F.R. § 1300.22(D). SECTION 405(C) FUNDING IS AVIALABLE FOR STATE TRAFFIC SAFETY INFORMATION SYSTEM IMPROVEMENTS. QUALIFYING STATES ARE THOSE THAT HAVE A TRAFFIC RECORDS COORDINATING COMMITTEE (TRCC); DESIGNATED TRCC COORDINATOR; AND AN APPROVED STATE TRAFFIC RECORDS STRATEGIC PLAN. THESE FUNDS ARE APPORTIONED USING STATUTORY APPORTIONMENT FORMULA. THESE FUNDS ARE PROVIDED TO THE STATE AND TERRITORIAL HIGHWAY SAFETY OFFICES BASED ON AN APPROVED TRIENNIAL HIGHWAY SAFETY PLAN THAT DETAILS PROBLEM IDENTIFICATION, PUBLIC PARTICIPATION AND ENGAGEMENT, PERFORMANCE MEASURES, COUNTERMEASURE STRATEGIES FOR PROGRAMMING FUNDS AND AN APPROVED ANNUAL GRANT APPLICATION THAT DETAILS PLANNED PROJECTS USING IDENTIFIED COUNTERMEASURE STRATEGIES FOR PROGRAMMING FUNDS TO HELP REDUCE CRASHES, INJURIES AND FATALITIES RESULTING FROM MOTOR VEHICLE CRASHES.

JHL CONCEPT DESIGN AND ANALYSIS SIKORSKY HIGH SPEED HELICOPTER DESIGN

SECTION 405(C) STATE TRAFFIC SAFETY INFORMATION SYSTEM IMPROVEMENTS GRANT

SECTION 405(C) STATE TRAFFIC SAFETY INFORMATION SYSTEM IMPROVEMENTS GRANT (23 C.F.R. § 1300.22; 23 U.S.C. § 405(C)) ― GRANT TO SUPPORT DATA PROGRAM IMPROVEMENTS IN THE ACCURACY, COMPLETENESS, TIMELINESS, UNIFORMITY, ACCESSIBILITY, OR INTEGRATION OF CORE HIGHWAY SAFETY DATABASES CONSISTENT WITH 23 C.F.R. § 1300.22(D). SECTION 405(C) FUNDING IS AVIALABLE FOR STATE TRAFFIC SAFETY INFORMATION SYSTEM IMPROVEMENTS. QUALIFYING STATES ARE THOSE THAT HAVE A TRAFFIC RECORDS COORDINATING COMMITTEE (TRCC); DESIGNATED TRCC COORDINATOR; AND AN APPROVED STATE TRAFFIC RECORDS STRATEGIC PLAN. THESE FUNDS ARE APPORTIONED USING STATUTORY APPORTIONMENT FORMULA. THESE FUNDS ARE PROVIDED TO THE STATE AND TERRITORIAL HIGHWAY SAFETY OFFICES BASED ON AN APPROVED TRIENNIAL HIGHWAY SAFETY PLAN THAT DETAILS PROBLEM IDENTIFICATION, PUBLIC PARTICIPATION AND ENGAGEMENT, PERFORMANCE MEASURES, COUNTERMEASURE STRATEGIES FOR PROGRAMMING FUNDS AND AN APPROVED ANNUAL GRANT APPLICATION THAT DETAILS PLANNED PROJECTS USING IDENTIFIED COUNTERMEASURE STRATEGIES FOR PROGRAMMING FUNDS TO HELP REDUCE CRASHES, INJURIES AND FATALITIES RESULTING FROM MOTOR VEHICLE CRASHES.

SECTION 405(C) STATE TRAFFIC SAFETY INFORMATION SYSTEMS

SECTION 405(C) STATE TRAFFIC SAFETY INFORMATION SYSTEM IMPROVEMENTS GRANT (23 C.F.R. & 1300.22; 23 U.S.C. & 405(C)) - GRANT TO SUPPORT DATA PROGRAM IMPROVEMENTS IN THE ACCURACY, COMPLETENESS, TIMELINESS, UNIFORMITY, ACCESSIBILITY, OR INTEGRATION OF CORE HIGHWAY SAFETY DATABASES.

SECTION 402 STATE AND COMMUNITY HIGHWAY

STATE AND COMMUNITY HIGHWAY SAFETY PROGRAM SEC 402 ¿¿ 20.600

SECTION 402 STATE AND COMMUNITY HIGHWAY

SECTION 402 STATE AND COMMUNITY HIGHWAY

SECTION 405(B) OCCUPANT PROTECTION GRANT (23 C.F.R. § 1300.21; 23 U.S.C. § 405(B)) €• GRANT TO SUPPORT CERTAIN COSTS OF STATE OCCUPANT PROTECTION PROGRAMS CONSISTENT WITH 23 C.F.R. § 1300.21(F). SECTION 405(B) FUNDING IS AVAILABLE TO QUALIFYING STATES THAT MEET STATUTORY REQUIREMENTS FOR A HIGH OR LOW SEAT BELT USE CATEGORIES. THESE FUNDS ARE APPORTIONED USING STATUTORY APPORTIONMENT FORMULA. THESE FUNDS ARE PROVIDED TO THE STATE AND TERRITORIAL HIGHWAY SAFETY OFFICES BASED ON AN APPROVED TRIENNIAL HIGHWAY SAFETY PLAN THAT DETAILS PROBLEM IDENTIFICATION, PUBLIC PARTICIPATION AND ENGAGEMENT, PERFORMANCE MEASURES, COUNTERMEASURE STRATEGIES FOR PROGRAMMING FUNDS AND AN APPROVED ANNUAL GRANT APPLICATION THAT DETAILS PLANNED PROJECTS USING IDENTIFIED COUNTERMEASURE STRATEGIES FOR PROGRAMMING FUNDS TO HELP REDUCE CRASHES, INJURIES AND FATALITIES RESULTING FROM MOTOR VEHICLE CRASHES.

SECTION 405(B) OCCUPANT PROTECTION GRANT (23 C.F.R. § 1300.21; 23 U.S.C. § 405(B)) ― GRANT TO SUPPORT CERTAIN COSTS OF STATE OCCUPANT PROTECTION PROGRAMS CONSISTENT WITH 23 C.F.R. § 1300.21(F). SECTION 405(B) FUNDING IS AVAILABLE TO QUALIFYING STATES THAT MEET STATUTORY REQUIREMENTS FOR A HIGH OR LOW SEAT BELT USE CATEGORIES. THESE FUNDS ARE APPORTIONED USING STATUTORY APPORTIONMENT FORMULA. THESE FUNDS ARE PROVIDED TO THE STATE AND TERRITORIAL HIGHWAY SAFETY OFFICES BASED ON AN APPROVED TRIENNIAL HIGHWAY SAFETY PLAN THAT DETAILS PROBLEM IDENTIFICATION, PUBLIC PARTICIPATION AND ENGAGEMENT, PERFORMANCE MEASURES, COUNTERMEASURE STRATEGIES FOR PROGRAMMING FUNDS AND AN APPROVED ANNUAL GRANT APPLICATION THAT DETAILS PLANNED PROJECTS USING IDENTIFIED COUNTERMEASURE STRATEGIES FOR PROGRAMMING FUNDS TO HELP REDUCE CRASHES, INJURIES AND FATALITIES RESULTING FROM MOTOR VEHICLE CRASHES.

2011 WORK ZONE SAFETY GRANT

DEVELOPMENT OF 2-DEOXY-D-GLUCOSE FOR THE TREATMENT OF POLYCYSTIC KIDNEY DISEASE

SECTION 405(B) OCCUPANT PROTECTION GRANT (23 C.F.R. & 1300.21; 23 U.S.C. & 405(B)) - GRANT TO SUPPORT CERTAIN COSTS OF STATE OCCUPANT PROTECTION PROGRAMS CONSISTENT WITH 23 C.F.R. & 1300.21(F).

SECTION 405(B) OCCUPANT PROTECTION

TOTAL HYBRID ELECTRIC MANAGEMENT AND INTEGRATION SYSTEM THEMIS

SECTION 405(B) OCCUPANT PROTECTION GRANT

CONSTRUCT A TCD FOR ITSWATER INTAKE FACILITIES ON FOLSOM LAKE

JOINT MULTI-ROLE DEMONSTRATOR CONFIGURATION TRADES AND ANALYSIS

SECTION 405 (C)STATE TRAFFIC SAFETY INFORMATION SYSTEM IMPROVEMENTS

SECTION 405(C) STATE TRAFFIC SAFETY INFORMATION SYSTEM IMPROVEMENTS GRANT

SECTION 405(C) STATE TRAFFIC SAFETY INFORMATION SYSTEM IMPROVEMENTS GRANT

ACTIVE ROTOR COMPONENT DEMONSTRATION

SECTION 410 ALCOHOL TRAFFIC SAFETY AND DRUNK DRIVING PREVENTION INCENTIVE GRANTS

SECTION 405 (C)STATE TRAFFIC SAFETY INFORMATION SYSTEM IMPROVEMENTS

THIS ACTIVITY WILL CONTRIBUTE TO THE IMPROVEMENT OF THE QUALITY OF LIFE OF SOYAPANGO FAMILIES, THROUGH THE ARTICULATION OF KEY SECTORS AND THE CREATION OF PLATFORMS TO INCREASE OPPORTUNITIES FOR ECONOMIC AND SOCIAL DEVELOPMENT IN THE AREA. THIS ACTIVITY IDENTIFIES THE MULTIPLE RISK FACTORS FOR MIGRATION AND ADDRESSES THEM WITH A HOLISTIC APPROACH, WHICH PROVIDES AT-RISK COMMUNITIES IN SOYAPANGO WITH EFFECTIVE TOOLS THAT INCREASE JOB OPPORTUNITIES AND IMPROVE SOCIAL DEVELOPMENT AND HOPE FOR A FUTURE IN EL SALVADOR, WHICH IN RETURN DECREASES THE LIKELIHOOD OF ILLEGAL MIGRATION.

SECTION 405(D) IMPAIRED DRIVING COUNTERMEASURES GRANT (23 C.F.R. § 1300.23; 23 U.S.C. § 405(D)) ― GRANT TO SUPPORT CERTAIN COSTS OF STATE IMPAIRED DRIVING COUNTERMEASURES PROGRAMS CONSISTENT WITH 23 C.F.R. § 1300.23(J). 405(D) FUNDING IS USED FOR IMPAIRED DRIVING COUNTERMEASURES. QUALIFYING STATES MUST MEET STATUTORY REQUIREMENTS AND CAN ALSO RECEIVE FUNDING FOR ADOPTION AND ENFORCEMENT A MANDATORY ALCOHOL-IGNITION INTERLOCK LAWS AND 24/7 SOBRIETY PROGRAMS. THESE FUNDS ARE APPORTIONED USING STATUTORY APPORTIONMENT FORMULA. THESE FUNDS ARE PROVIDED TO THE STATE AND TERRITORIAL HIGHWAY SAFETY OFFICES BASED ON AN APPROVED TRIENNIAL HIGHWAY SAFETY PLAN THAT DETAILS PROBLEM IDENTIFICATION, PUBLIC PARTICIPATION AND ENGAGEMENT, PERFORMANCE MEASURES, COUNTERMEASURE STRATEGIES FOR PROGRAMMING FUNDS AND AN APPROVED ANNUAL GRANT APPLICATION THAT DETAILS PLANNED PROJECTS USING IDENTIFIED COUNTERMEASURE STRATEGIES FOR PROGRAMMING FUNDS TO HELP REDUCE CRASHES, INJURIES AND FATALITIES RESULTING FROM MOTOR VEHICLE CRASHES.

SECTION 405(D) IMPAIRED DRIVING COUNTERMEASURES GRANT (23 C.F.R. § 1300.23; 23 U.S.C. § 405(D)) €• GRANT TO SUPPORT CERTAIN COSTS OF STATE IMPAIRED DRIVING COUNTERMEASURES PROGRAMS CONSISTENT WITH 23 C.F.R. § 1300.23(J). 405(D) FUNDING IS USED FOR IMPAIRED DRIVING COUNTERMEASURES. QUALIFYING STATES MUST MEET STATUTORY REQUIREMENTS AND CAN ALSO RECEIVE FUNDING FOR ADOPTION AND ENFORCEMENT A MANDATORY ALCOHOL-IGNITION INTERLOCK LAWS AND 24/7 SOBRIETY PROGRAMS. THESE FUNDS ARE APPORTIONED USING STATUTORY APPORTIONMENT FORMULA. THESE FUNDS ARE PROVIDED TO THE STATE AND TERRITORIAL HIGHWAY SAFETY OFFICES BASED ON AN APPROVED TRIENNIAL HIGHWAY SAFETY PLAN THAT DETAILS PROBLEM IDENTIFICATION, PUBLIC PARTICIPATION AND ENGAGEMENT, PERFORMANCE MEASURES, COUNTERMEASURE STRATEGIES FOR PROGRAMMING FUNDS AND AN APPROVED ANNUAL GRANT APPLICATION THAT DETAILS PLANNED PROJECTS USING IDENTIFIED COUNTERMEASURE STRATEGIES FOR PROGRAMMING FUNDS TO HELP REDUCE CRASHES, INJURIES AND FATALITIES RESULTING FROM MOTOR VEHICLE CRASHES.

SECTION 405(C) STATE TRAFFIC SAFETY INFORMATION SYSTEMS IMPROVEMENT

SECTION 405(C) STATE TRAFFIC SAFETY INFORMATION SYSTEMS IMPROVEMENT

SECTION 405(C) STATE TRAFFIC SAFETY INFORMATION SYSTEMS IMPROVEMENT

SECTION 405(D) IMPAIRED DRIVING COUNTERMEASURES GRANT (23 C.F.R. & 1300.23; 23 U.S.C. & 405(D)) - GRANT TO SUPPORT CERTAIN COSTS OF STATE ALCOHOL-IMPAIRED DRIVING PROGRAMS CONSISTENT WITH 23 C.F.R. & 1300.23(J).

SECTION 405(B) OCCUPANT PROTECTION GRANT

SECTION 405(B) OCCUPANT PROTECTION

SECTION 405(B) OCCUPANT PROTECTION GRANT

SECTION 405(B) OCCUPANT PROTECTION

SECTION 405(B) OCCUPANT PROTECTION

SECTION 405(D) IMPAIRED DRIVING COUNTERMEASURES GRANT

SECTION 405(B) OCCUPANT PROTECTION

ADVANCED TEAMING (A-TEAM) DEMONSTRATION PROGRAM SUBSYSTEMS TECHNOLOGY DEVELOPMENT AND INTEGRATION OPERATIONS MANAGEMENT - INCREMENTAL FUNDING

SECTION 405(G) NONMOTORIZED SAFETY GRANT (23 C.F.R. § 1300.26; 23 U.S.C. § 405(G)) €• GRANT TO SUPPORT PROGRAMS TO DECREASE NONMOTORIZED ROAD USER FATALITIES INVOLVING A MOTOR VEHICLE IN TRANSIT ON A TRAFFICWAY CONSISTENT WITH 23 C.F.R. § 1300.26(E). 405(G) FUNDING IS AVAILABLE TO QUALIFYING STATES WHERE THE STATE'S ANNUAL COMBINED NONMOTORIZED ROAD USER FATALITIES EXCEED 15 PERCENT OF THE STATE'S TOTAL ANNUAL CRASH FATALITIES BASED ON THE MOST RECENT CALENDAR YEAR FOR WHICH FINAL FARS DATA ARE AVAILABLE, AS DETERMINED BY NHTSA. THESE FUNDS ARE APPORTIONED USING STATUTORY APPORTIONMENT FORMULA. THESE FUNDS ARE PROVIDED TO THE STATE AND TERRITORIAL HIGHWAY SAFETY OFFICES BASED ON AN APPROVED TRIENNIAL HIGHWAY SAFETY PLAN THAT DETAILS PROBLEM IDENTIFICATION, PUBLIC PARTICIPATION AND ENGAGEMENT, PERFORMANCE MEASURES, COUNTERMEASURE STRATEGIES FOR PROGRAMMING FUNDS AND AN APPROVED ANNUAL GRANT APPLICATION THAT DETAILS PLANNED PROJECTS USING IDENTIFIED COUNTERMEASURE STRATEGIES FOR PROGRAMMING FUNDS TO HELP REDUCE CRASHES, INJURIES AND FATALITIES RESULTING FROM MOTOR VEHICLE CRASHES.

SECTION 154 ALCOHOL OPEN CONTAINER LAW TRANSFER PROGRAM

SECTION 405(D) IMPAIRED DRIVING COUNTERMEASURES & IGNITION INTERLOCK

SECTION 405(D) IMPAIRED DRIVING COUNTERMEASURES

BI-BIL 405I DRIVER AND OFFICER SAFETY 24-27

FY 2008 SECTION 164 REPEAT OFFENDER TRANSFER FUNDS

FY 2008 SECTION 154 OPEN CONTAINER TRANSFER FUNDS

SECTION 164 REPEAT INTOXICATED DRIVER LAW TRANSFER PROGRAM

SECTION 154 OPEN CONTAINER LAW TRANSFER PROGRAM

TARGETING LIPID RAFTS FOR TREATMENT OF ASTHMA - PROJECT SUMMARY PATIENTS WITH SEVERE ASTHMA WHO DISPLAY PERSISTENT BRONCHOCONSTRICTION AND/OR REDUCED LUNG FUNCTION DESPITE AVAILABLE BRONCHODILATOR, CORTICOSTEROID AND TH2-TARGETING THERAPY DEVELOP SIGNIFICANT MORBIDITY, WHICH SEVERELY IMPACTS THEIR QUALITY OF LIFE OWING TO PERSISTENT SYMPTOMS, AS WELL AS FREQUENT AND LIFE-THREATENING EXACERBATIONS. ASPECTS OF SEVERE ASTHMA CURRENTLY NOT MANAGED BY AVAILABLE THERAPIES MAY DISPLAY A STRONG INFLAMMATORY COMPONENT DRIVEN BY THE INNATE AND ADAPTIVE IMMUNE SYSTEMS, PARTICULARLY FOLLOWING VIRAL EXACERBATIONS. DEVELOPMENT OF NEW THERAPEUTIC STRATEGIES TARGETING A WIDE RANGE OF INFLAMMATORY MECHANISMS, NOT ONLY TH2 AND TH1/TH17 RESPONSES, IS NEEDED TO CONTROL SEVERE ASTHMA. RAFT PHARMACEUTICALS PROPOSES A NEW TARGET FOR TREATMENT OF SEVERE ASTHMA – OVERABUNDANT AND CLUSTERED, PATHOLOGICAL LIPID RAFTS IN BRONCHIAL EPITHELIAL AND IMMUNE CELLS IN ASTHMATICS. CHOLESTEROL-RICH LIPID RAFTS PROVIDE ORDERED PLASMA MEMBRANE DOMAINS, WHERE RECEPTORS, ION CHANNELS AND ADAPTOR MOLECULES CAN ASSOCIATE TO FORM FUNCTIONAL COMPLEXES. LARGE LIPID RAFTS ARE REQUIRED AS THE LANDING PAD FOR MICROBES ON HOST CELLS AND FOR INITIATION OF MANY INFLAMMATORY PROCESSES IN BRONCHIAL EPITHELIAL AND IMMUNE CELLS. WE DISCOVERED APOA-I BINDING PROTEIN (AIBP) AS A MOLECULE THAT SELECTIVELY TARGETS THE CHOLESTEROL DEPLETION MACHINERY TO PATHOLOGIC LIPID RAFTS IN INFLAMMATORY CELLS, WITHOUT AFFECTING HOMEOSTATIC CELLULAR FUNCTION. THE LATTER EXPLAINS AN EXCEPTIONAL SAFETY PROFILE OF AIBP IN MICE AND RATS. IN THE PHASE I OF THIS GRANT, USING MOUSE MODELS OF ASTHMA, WE DEMONSTRATED THAT ADMINISTRATION OF A BIOLOGIC DERIVED FROM THE AIBP PROTEIN, WAS EFFECTIVE IN AN ACUTE HDM MODEL OF ASTHMA IN MICE, REDUCING AIRWAY HYPERRESPONSIVENESS, AIRWAY EOSINOPHILIA, AND EXPRESSION OF TH2 CYTOKINES AND EPITHELIAL ALARMINS. IN A MODEL OF SEVERE ASTHMA, AIBP SIGNIFICANTLY REDUCED PULMONARY NEUTROPHILIA. FOR PHASE II PROPOSAL, A TEAM OF EXPERTS IN BIOLOGIC DRUG DEVELOPMENT AND IN PRECLINICAL ASSESSMENT AND CLINICAL TRIALS OF THERAPEUTIC AGENTS IN ASTHMA HAS BEEN ASSEMBLED TO FURTHER THE CHARACTERIZATION OF AN IMPROVED AIBP SEQUENCE, RFT1124, AS A DEVELOPMENT CANDIDATE FOR SEVERE ASTHMA. SPECIFICALLY, WE PLAN TO MANUFACTURE AND RELEASE RFT1124 DRUG PRODUCT FOR EFFICACY AND TOXICOLOGY STUDIES USING CGMP-COMPATIBLE PROCESSES AND ANALYTICAL ASSAYS. THE EFFICACY OF RFT1124 AS AN ADD-ON THERAPY TO STANDARD-OF-CARE INHALED CORTICOSTEROIDS AND LONG-ACTING BETA-AGONISTS (ICS+LABA) WILL BE TESTED IN MOUSE MODELS OF ASTHMA EXACERBATED BY RHINOVIRUS (RV) INFECTION. IN ADDITION, WE WILL USE PRECISION CUT LUNG SLICES FROM ASTHMATICS AND NON-ASTHMATICS POSTMORTEM LUNG TISSUE TO TEST THE EFFICACY OF ADD-ON RFT1124 IN ICS+LABA TREATMENT IN RV INFECTED HUMAN AIRWAYS. RNASEQ STUDIES WILL ESTABLISH WHETHER RFT1124 INHIBITS CORTICOSTEROID INSENSITIVE ANTI-INFLAMMATORY PATHWAYS AND/OR ENHANCES CORTICOSTEROID SENSITIVE PATHWAYS IN RV INFECTED HUMAN BRONCHIAL EPITHELIAL CELLS. FURTHER, A NON-GLP SAFETY ASSESSMENT OF INTRANASAL DELIVERY OF RFT1124 WILL BE CONDUCTED TO ESTABLISH AN ESTIMATE OF SAFETY MARGIN AND TARGET ORGANS. THESE RESULTS WILL BE USED TO PREPARE FOR AND CONDUCT PRE-IND (TYPE B) MEETING WITH THE FDA.

COVID RELIEF FOR BIOFUEL PRODUCERS GRANTS

SECTION 405(G) NONMOTORIZED SAFETY GRANT (23 C.F.R. § 1300.26; 23 U.S.C. § 405(G)) ― GRANT TO SUPPORT PROGRAMS TO DECREASE NONMOTORIZED ROAD USER FATALITIES INVOLVING A MOTOR VEHICLE IN TRANSIT ON A TRAFFICWAY CONSISTENT WITH 23 C.F.R. § 1300.26(E). 405(G) FUNDING IS AVAILABLE TO QUALIFYING STATES WHERE THE STATE'S ANNUAL COMBINED NONMOTORIZED ROAD USER FATALITIES EXCEED 15 PERCENT OF THE STATE'S TOTAL ANNUAL CRASH FATALITIES BASED ON THE MOST RECENT CALENDAR YEAR FOR WHICH FINAL FARS DATA ARE AVAILABLE, AS DETERMINED BY NHTSA. THESE FUNDS ARE APPORTIONED USING STATUTORY APPORTIONMENT FORMULA. THESE FUNDS ARE PROVIDED TO THE STATE AND TERRITORIAL HIGHWAY SAFETY OFFICES BASED ON AN APPROVED TRIENNIAL HIGHWAY SAFETY PLAN THAT DETAILS PROBLEM IDENTIFICATION, PUBLIC PARTICIPATION AND ENGAGEMENT, PERFORMANCE MEASURES, COUNTERMEASURE STRATEGIES FOR PROGRAMMING FUNDS AND AN APPROVED ANNUAL GRANT APPLICATION THAT DETAILS PLANNED PROJECTS USING IDENTIFIED COUNTERMEASURE STRATEGIES FOR PROGRAMMING FUNDS TO HELP REDUCE CRASHES, INJURIES AND FATALITIES RESULTING FROM MOTOR VEHICLE CRASHES.

PROVIDE ASSISTANCE TO STATES ON THE IMPLEMENTATION AND OPERATION OF IGNITION INTERLOCK PROGRAMS AND PROVEN IMPAIRED DRIVING COUNTERMEASURES. UPDATE THE ALCOHOL INTERLOCK CURRICULUM FOR PRACTITIONERS AND SUPPORT THE WORKING GROUP ON DWI SYSTEM IMPROVEMENTS.

SECTION 405(E) DISTRACTED DRIVING AWARENESS GRANT (23 C.F.R. § 1300.24; 23 U.S.C. § 405(E)) ― GRANT TO SUPPORT CERTAIN COSTS OF STATE DISTRACTED DRIVING PROGRAMS CONSISTENT WITH 23 C.F.R. § 1300.24(F). 405(E) FUNDING IS AVAILABLE TO QUALIFYING STATES THAT ENACT AND ENFORCE A LAW THAT PROHIBITS TEXTING WHILE DRIVING OR PROHIBITS YOUTH CELL PHONE USE WHILE DRIVING. THESE FUNDS ARE PROVIDED TO THE STATE AND TERRITORIAL HIGHWAY SAFETY OFFICES BASED ON AN APPROVED TRIENNIAL HIGHWAY SAFETY PLAN THAT DETAILS PROBLEM IDENTIFICATION, PUBLIC PARTICIPATION AND ENGAGEMENT, PERFORMANCE MEASURES, COUNTERMEASURE STRATEGIES FOR PROGRAMMING FUNDS AND AN APPROVED ANNUAL GRANT APPLICATION THAT DETAILS PLANNED PROJECTS USING IDENTIFIED COUNTERMEASURE STRATEGIES FOR PROGRAMMING FUNDS TO HELP REDUCE CRASHES, INJURIES AND FATALITIES RESULTING FROM MOTOR VEHICLE CRASHES.

SECTION 405(D) IMPAIRED DRIVING COUNTERMEASURES GRANT

SECTION 405(D) IMPAIRED DRIVING COUNTERMEASURES GRANT

SECTION 405(D) IMPAIRED DRIVING COUNTERMEASURES

SECTION 405 OCCUPANT PROTECTION INCENTIV

SECTION 405(D) IMPAIRED DRIVING COUNTERMEASURES GRANT (23 C.F.R. § 1300.23; 23 U.S.C. § 405(D)) ― GRANT TO SUPPORT CERTAIN COSTS OF STATE ALCOHOL-IMPAIRED DRIVING PROGRAMS CONSISTENT WITH 23 C.F.R. § 1300.23(J).

SECTION 405(D) IMPAIRED DRIVING COUNTERMEASURES

SECTION 405 OCCUPANT PROTECTION INCENTIV

SECTION 405(D) IMPAIRED DRIVING COUNTERMEASURES

SECTION 402 STATE AND COMMUNITY HIGHWAY

STRENGTHEN CHILD PROTECTION MECHANISMS AND ANTITRAFFICKING EFFORTS IN BANGLADESH, INDIA, AND NEPAL

SECTION 405(I) DRIVER AND OFFICER SAFETY EDUCATION GRANT (23 C.F.R. § 1300.28; 23 U.S.C. § 405(I)) €• GRANT TO SUPPORT STATES THAT ENACT AND ENFORCE A LAW OR ADOPT AND IMPLEMENT PROGRAMS THAT INCLUDE CERTAIN INFORMATION ON LAW ENFORCEMENT PRACTICES DURING TRAFFIC STOPS IN DRIVER EDUCATION AND TRAINING COURSES OR PEACE OFFICER TRAINING PROGRAMS CONSISTENT WITH 23 C.F.R. § 1300.28(H)€. 405(I) FUNDING IS AVAILABLE TO QUALIFYING STATES THAT ENACT AND ENFORCE A LAW OR ADOPT AND IMPLEMENT PROGRAMS THAT INCLUDE CERTAIN INFORMATION ON LAW ENFORCEMENT PRACTICES DURING TRAFFIC STOPS IN DRIVER EDUCATION AND TRAINING COURSES OR PEACE OFFICER TRAINING PROGRAMS. THESE FUNDS ARE APPORTIONED USING STATUTORY APPORTIONMENT FORMULA. THESE FUNDS ARE PROVIDED TO THE STATE AND TERRITORIAL HIGHWAY SAFETY OFFICES BASED ON AN APPROVED TRIENNIAL HIGHWAY SAFETY PLAN THAT DETAILS PROBLEM IDENTIFICATION, PUBLIC PARTICIPATION AND ENGAGEMENT, PERFORMANCE MEASURES, COUNTERMEASURE STRATEGIES FOR PROGRAMMING FUNDS AND AN APPROVED ANNUAL GRANT APPLICATION THAT DETAILS PLANNED PROJECTS USING IDENTIFIED COUNTERMEASURE STRATEGIES FOR PROGRAMMING FUNDS TO HELP REDUCE CRASHES, INJURIES AND FATALITIES RESULTING FROM MOTOR VEHICLE CRASHES.

SECTION 405(D) IMPAIRED DRIVING COUNTERMEASURES

SECTION 410 ALCOHOL SAFETEA-LU

SECTION 410 ALCOHOL TRAFFIC SAFETY AND DRUNK DRIVING PREVENTION INCENTIVE GRANTS

2016 WORK ZONE SAFETY TRAINING

SECTION 410 ALCOHOL SAFETEA-LU

CRIMINAL JUSTICE INSTITUTIONS AND CITES AUTHORITIES IN THE PHILIPPINES INCREASE THEIR COMMITMENT KNOWLEDGE AND SKILLS TO SUCCESSFULLY INVESTIGATE AND ENFORCE AGAINST WILDLIFE CRIMES.

EARLY HEAD START / CHILD CARE PARTNERSHIP

SECTION 405(E) DISTRACTED DRIVING AWARENESS GRANT (23 C.F.R. § 1300.24; 23 U.S.C. § 405(E)) €• GRANT TO SUPPORT CERTAIN COSTS OF STATE DISTRACTED DRIVING PROGRAMS CONSISTENT WITH 23 C.F.R. § 1300.24(F). 405(E) FUNDING IS AVAILABLE TO QUALIFYING STATES THAT ENACT AND ENFORCE A LAW THAT PROHIBITS TEXTING WHILE DRIVING OR PROHIBITS YOUTH CELL PHONE USE WHILE DRIVING. THESE FUNDS ARE PROVIDED TO THE STATE AND TERRITORIAL HIGHWAY SAFETY OFFICES BASED ON AN APPROVED TRIENNIAL HIGHWAY SAFETY PLAN THAT DETAILS PROBLEM IDENTIFICATION, PUBLIC PARTICIPATION AND ENGAGEMENT, PERFORMANCE MEASURES, COUNTERMEASURE STRATEGIES FOR PROGRAMMING FUNDS AND AN APPROVED ANNUAL GRANT APPLICATION THAT DETAILS PLANNED PROJECTS USING IDENTIFIED COUNTERMEASURE STRATEGIES FOR PROGRAMMING FUNDS TO HELP REDUCE CRASHES, INJURIES AND FATALITIES RESULTING FROM MOTOR VEHICLE CRASHES.

SECTION 405(E) DISTRACTED DRIVING

STATE TRAFFIC SAFETY INFORMATION SYSTEM IMPROVEMENT GRANTS SEC 408

HIGH PERFORMANCE, LOW VIBRATION, AND LOW NOISE ENABLING TECH PROGRAM

2013 WORK ZONE SAFETY GRANTS

ERADICATION OF IN VIVO STAPHYLOCOCCUS AUREAUS BIOFILMS WITH LYSIN CF-301

STRENGTHEN EAST AFRICA FRONT-LINE WILDLIFE LAW ENFORCEMENT

TRAFFIC TECHNOLOGY SERVICES, INC. NEW OPEN 2021 AWARD CONTROL NUMBER: 2459-2552 TITLE: AUTONOMOUS INTELLIGENT ASSISTANT (AUTONOMIA): RESILIENT AND ENERGY-EFFICIENT CITY-WIDE TRANSPORTATION OPERATIONS PACIFIC NORTHWEST NATIONAL LABORATORY, THE UNIVERSITY OF CALIFORNIA AT BERKELEY, AIMSUN, SIEMENS TECHNOLOGY, TRAFFIC TECHNOLOGY SERVICES, AND THE CITY OF CORAL GABLES, FL, WILL COMBINE ARTIFICIAL INTELLIGENCE WITH MULTISCALE SIMULATION AND REAL-TIME CONTROL TO REDUCE CONGESTION, IMPROVE ENERGY EFFICIENCY, AND REDUCE CO2 EMISSIONS ACROSS REGIONAL TRANSPORTATION SYSTEMS. AUTONOMIA’S TRAFFIC FORECASTING AND REAL-TIME MANAGEMENT APPROACH WILL LEVERAGE EMERGENT CONNECTED AUTOMATED VEHICLES WITH VARIED LEVELS OF AUTONOMY (CAVS), SENSING, AND SIGNALING TECHNOLOGIES WITHIN A UNIFIED LEARNING, SIMULATION, AND CONTROL PARADIGM TO IMPROVE ENERGY EFFICIENCY BY MORE THAN 20% AND TO REDUCE EMISSION BY AT LEAST 20%.

SECTION 405(D) IMPAIRED DRIVING COUNTERMEASURES

NOVEL BIOLOGIC TO TREAT CHEMOTHERAPY-INDUCED NEUROPATHIC PAIN - PROJECT SUMMARY CHEMOTHERAPY-INDUCED PERIPHERAL NEUROPATHY (CIPN) HAS A PROFOUND NEGATIVE IMPACT ON QUALITY OF LIFE OF NEARLY 70% OF CANCER PATIENTS RECEIVING CHEMOTHERAPY. WHILE SYSTEMIC ADMINISTRATION OF OPIATES, NSAIDS, AND ANTICONVULSANTS CAN RELIEVE PAIN FOR SHORT INTERVALS, THEY ARE NOT SUITABLE FOR CHRONIC THERAPY. ASIDE FROM EFFICACY, MANY OF THE POTENT AGENTS ARE BESET WITH LIMITING SIDE EFFECTS AND ISSUES RELATED TO DEPENDENCE AND ADDICTION. RAFT PHARMACEUTICALS (RAFT) PROPOSES A DIRECT-TO-PHASE 2 SBIR PROPOSAL PRESENTING A NOVEL APPROACH TO REVERSAL OF PREEXISTING NEUROPATHIC PAIN VIA REGULATION OF LIPID RAFTS IN SPINAL AND DORSAL ROOT GANGLIA (DRG) CELLS. OUR LEAD CANDIDATE, RFT1081, WHICH IS A MODIFIED APOA-I BINDING PROTEIN (AIBP), PROMOTES REMOVAL OF CHOLESTEROL SELECTIVELY FROM THE PLASMA MEMBRANE OF ACTIVATED AND INFLAMMATORY CELLS. THIS TARGETING IS DUE TO AIBP BINDING TO TOLL-LIKE RECEPTOR 4 (TLR4), WHICH IS HIGHLY EXPRESSED ON THE SURFACE OF INFLAMMATORY MICROGLIA, MACROPHAGES AND ACTIVATED DRG NOCICEPTORS. RFT1081-MEDIATED DISRUPTION OF LIPID RAFTS HARBORING ACTIVATED TLR4 ABROGATES THE FACILITATORY CYCLE OF NEUROINFLAMMATION AND NOCICEPTORS’ SPONTANEOUS ACTIVITY AND ALLEVIATES CHRONIC PAIN PHENOTYPES. IN A PRIOR PROJECT, WE DEVELOPED A NON-GMP SCALED-UP UPSTREAM AND DOWNSTREAM MANUFACTURING PROCESS FOR RFT1081 AND CONDUCTED ITS DETAILED CHARACTERIZATION; CONDUCTED PHARMACOKINETICS STUDIES OF SPINALLY DELIVERED RFT1081 IN MICE AND DESIGNED PHARMACODYNAMICS ASSAYS TO EVALUATE RFT1081 TARGET ENGAGEMENT; ESTABLISHED DOSE-DEPENDENT EFFICACY PROFILE FOR AIBP TREATMENT IN CIPN MICE; AND CONDUCTED A NON-GLP DOSE-RANGE TOLERABILITY STUDY OF RFT1081 IN RATS. THESE DATA PROVIDE SUPPORT AND JUSTIFY FURTHER DEVELOPMENT OF RFT1081 IN THE PROPOSED DIRECT-TO-PHASE 2 SBIR STUDIES. IN THIS MILESTONES-DRIVEN PROJECT, WE PLAN TO MANUFACTURE A RFT1081 DRUG PRODUCT LOT FOR TOXICOLOGY STUDIES USING A CGMP-COMPATIBLE PROCESS AND ANALYTICAL ASSAYS. THE RFT1081 DRUG PRODUCT LOT, CONFORMING TO RAFT’S SPECIFICATIONS AND IN OPTIMIZED FORMULATION WILL BE THOROUGHLY CHARACTERIZED FOR STORAGE AND IN-USE STABILITY. THE INITIAL SINGLE-DOSE TOXICOLOGY STUDIES WILL BE PERFORMED IN RATS. WE WILL THEN ALSO EVALUATE THE PHARMACOLOGY, LOCAL AND SYSTEMIC TOXICITY, AND IMMUNE RESPONSE TO REPEATED I.T. ADMINISTRATION OF RAFT1081 IN RATS, DOGS AND NON-HUMAN PRIMATES TO FURTHER STUDY THE SAFETY OF THE DRUG AND TO SELECT A PHARMACOLOGICALLY RELEVANT NON-RODENT SPECIES FOR FURTHER IND- ENABLING PRECLINICAL EVALUATION. RFT1081 WILL ALSO BE EVALUATED IN A MODEL OF CISPLATIN CANCER THERAPY TO ENSURE IT DOES NOT INTERFERE WITH CHEMOTHERAPY ACTION. THE PROJECT WILL CONCLUDE WITH DEVELOPING A DETAILED SYNOPSIS OF AN INTEGRATED FIRST-IN-HUMAN STUDY AND AN OVERALL INDICATION-SUPPORTING CLINICAL STRATEGY, FOLLOWED BY PREPARATION FOR AND CONDUCTING A PRE-IND MEETING WITH THE FDA. WE EXPECT THAT THIS PHASE 2 SBIR PROJECT OUTCOMES WILL INCLUDE: 1) SUCCESSFUL SCALE-UP OF RFT1081 SUITABLE FOR FUTURE CGMP MANUFACTURING, 2) COMPLETION OF DOSE- RANGING TOXICOLOGY STUDIES AND SELECTION OF A RELEVANT NON-RODENT SPECIES, AND 3) A VIABLE IND-ENABLING AND CLINICAL DEVELOPMENT STRATEGY VETTED WITH THE FDA TO DE-RISK FUTURE STEPS OF RFT1081 DEVELOPMENT.

HUMAN TRAFFICKING VICTIMS HAVE COMPLEX LEGAL NEEDS BUT DUE TO A LACK IN IDENTIFICATION, MANY CANNOT ACCESS THE FULL SPECTRUM OF LEGAL RELIEF AVAILABLE TO THEM. EVEN WHEN VICTIMS ARE IDENTIFIED, THE DEMAND FOR LEGAL SERVICES OUTPACES THE NUMBER OF LEGAL PROVIDERS IN THE COUNTRY WHO ARE ADEQUATELY TRAINED IN TRAUMA-INFORMED AND RACIALLY EQUITABLE SERVICES. AS A RESULT, LEGAL SERVICES ARE AN UNMET NEED OF TRAFFICKING VICTIMS AND COMPRESSED TRAINING ON THE LEGAL NEEDS OF AND ETHICAL PROVISION SERVICES TO TRAFFICKING VICTIMS IS IN HIGH DEMAND. THROUGH ITS EXPERT LEGAL AND SOCIAL SERVICES STAFF, THE COALITION TO ABOLISH SLAVERY AND TRAFFICKING (CAST) PROPOSES TO CONTINUE ITS COMPREHENSIVE, NATIONAL, ACCESSIBLE AND INCLUSIVE TRAINING AND TECHNICAL ASSISTANCE (TTA) PROJECT TO STRENGTHEN LEGAL SERVICE PROVIDERS, PRO BONO ATTORNEYS, AND SOCIAL SERVICE PROVIDERS CAPACITY TO IDENTIFY AND PROVIDE COMPREHENSIVE LEGAL SERVICES TO VICTIMS OF HUMAN TRAFFICKING THROUGH A TRAUMA-INFORMED AND RACE EQUITY LENS. IN PARTNERSHIP WITH THE OFFICE FOR VICTIMS OF CRIME, CAST WILL BUILD ON OVER 15 YEARS OF PROVIDING TTA TO DEEPEN AND EXPAND ITS NATIONAL TTA EFFORTS TO INCREASE TRAFFICKING VICTIMS ACCESS TO QUALITY COMPREHENSIVE LEGAL SERVICES. ADDITIONALLY, CAST WILL LEVERAGE COLLABORATION WITH MANY NATIONAL PARTNERS LIKE FREEDOM NETWORK USAS SURVIVOR REENTRY PROJECT TO PROVIDE COMPREHENSIVE TTA. THE PROJECT WILL PROVIDE COMPREHENSIVE LIVE AND ON-DEMAND TRAINING TO LEGAL AND SOCIAL SERVICE PROVIDERS INCLUDING ANTI-TRAFFICKING LAWYERING TRAINING MODULE 2, INTENSIVE T VISA DECLARATION WORKSHOPS, AND VICTIMS RIGHTS ADVOCACY FOR SOCIAL SERVICE PROVIDERS, AS WELL AS SELF-PACED ONLINE TRAINING TO MANY MORE ATTORNEYS AND SOCIAL SERVICE PROVIDERS NATIONALLY THROUGH AN ADVANCED LEARNING MANAGEMENT SYSTEM FOR ASYNCHRONOUS AND SYNCHRONOUS LEARNING. CAST WILL ALSO CONTINUE TO PROVIDE INDIVIDUAL TECHNICAL ASSISTANCE TO 40 LEGAL AND SOCIAL SERVICE PROFESSIONALS A MONTH, AS WELL AS WEEKLY LEGAL WORKING GROUP CALLS AND MONTHLY OFFICE HOURS FOR SOCIAL SERVICE PROVIDERS. CAST WILL SUBGRANT TO FREEDOM NETWORK USA TO SUPPORT TTA ON CRIMINAL RECORD RELIEF, AND TO THE NATIONAL CRIME VICTIMS LAW INSTITUTE WHO WILL SUPPORTTTA ON CRIME VICTIMS RIGHTS. WHILE TARGETED BENEFICIARIES ARE LEGAL AND SOCIAL SERVICE PROVIDERS, ANYONE INTERESTED IN INCREASING KNOWLEDGE IN THIS AREA WILL BE ABLE TO ACCESS THE CAST TTA WEBSITE FOR MATERIALS ON POPULAR TOPICS. THROUGH THIS PROJECT, CAST WILL HAVE THE OPPORTUNITY TO CONTINUE TO TRANSFORM THE LANDSCAPE OF TRAINED LEGAL SERVICE PROVIDERS ASSISTING VICTIMS OF HUMAN TRAFFICKING AND TO VASTLY IMPROVE VICTIMS LIVES.

FINANCIAL ASSISTANCE AWARD

FINANCIAL ASSISTANCE AWARD

TO STRENGTHEN LAW ENFORCEMENT CAPACITY

NORTH EASTERN PASTORAL DEVELOPMENT PROGRAM

METABOQUEST: A SUITE OF TOOLS FOR METABOLITE ANNOTATION - METABOQUEST: A SUITE OF TOOLS FOR METABOLITE ANNOTATION PROJECT SUMMARY METABOLOMICS AIMS AT HIGH THROUGHPUT DETECTION, QUANTIFICATION, AND IDENTIFICATION OF METABOLITES IN BIOLOGICAL SAMPLES. THE USE OF LIQUID CHROMATOGRAPHY COUPLED WITH MASS SPECTROMETRY (LC-MS) HAS RISEN IN PROMINENCE IN THE FIELD OF METABOLOMICS DUE TO ITS ABILITY TO ANALYZE A SIZABLE NUMBER OF METABOLITES WITH A LIMITED AMOUNT OF BIOLOGICAL MATERIAL. HOWEVER, IN A TYPICAL UNTARGETED METABOLOMICS ANALYSIS OF HUMAN SAMPLES BY LC-MS, ABOUT 70% OF THE DETECTED PEAKS REPRESENT UNKNOWN ANALYTES MAINLY BECAUSE EXISTING MASS SPECTRAL LIBRARIES COVER ONLY A SMALL FRACTION OF KNOWN COMPOUNDS, BUT ALSO DUE TO UNCERTAINTY IN PEAK PICKING, ALIGNMENT OF PEAKS, AND RECOGNIZING ISOTOPIC PEAKS AND ADDUCT FORMS. THESE CHALLENGES HAVE KEPT AT BAY THE PACE OF DEVELOPMENT OF DATA ANALYTICS PIPELINES FOR METABOLOMICS AND ITS INTEGRATION WITH OTHER OMICS STUDIES. THE GOAL OF THIS PHASE II SBIR PROPOSAL IS TO MAKE METABOLOMICS STUDIES ON A PAR WITH OTHER OMICS STUDIES SUCH AS GENOMICS, TRANSCRIPTOMICS, AND PROTEOMICS, FOR WHICH WELL-ESTABLISHED PIPELINES ARE AVAILABLE. BY DOING SO, WE WILL ACCELERATE THE ROLE OF METABOLOMICS IN SYSTEMS BIOLOGY APPROACHES FOR VARIOUS APPLICATIONS INCLUDING BIOMARKER AND DRUG DISCOVERY. TO ACHIEVE THIS GOAL, WE PROPOSE TO DEVELOP A CLOUD-BASED PLATFORM THAT ALLOWS CUSTOMERS TO BUILD PIPELINES FOR ANALYSIS OF LC-MS-BASED UNTARGETED METABOLOMICS DATA, STARTING FROM PEAK DETECTION TO METABOLITE ANNOTATION. THIS WILL BE ACCOMPLISHED BY IMPLEMENTING A SUITE OF INNOVATIVE TOOLS THAT CAN BE ASSEMBLED INTO CUSTOMIZED PIPELINES AND BY ENHANCING METABOLITE ANNOTATION ACCURACY THROUGH INTEGRATION OF INFORMATION DERIVED FROM MULTIPLE RESOURCES INCLUDING COMPOUND DATABASES, PATHWAYS, BIOCHEMICAL NETWORKS, AND MASS SPECTRAL LIBRARIES. AIM 1 OF THIS PROPOSAL WILL FOCUS ON DEVELOPING A SUITE OF TOOLS TO ENABLE: (1) PEAK DETECTION, ALIGNMENT, AND QUALITY ASSESSMENT; (2) ADDUCT AND ISOTOPIC PEAK RECOGNITION; (3) MASS-BASED SEARCH AGAINST MULTIPLE COMPOUND DATABASES; (4) EXPERT-BASED EVALUATION OF PUTATIVE IDS; (5) ISOTOPIC PATTERN ANALYSIS; (6) NETWORK-BASED EVALUATION OF PUTATIVE IDS; (7) SPECTRAL MATCHING OF MS/MS DATA AGAINST EXPERIMENTAL AND IN- SILICO FRAGMENTATION PATTERNS; (8) DEEP LEARNING-BASED PREDICTION OF COMPOUND FINGERPRINTS; AND (9) INTEGRATIVE ASSESSMENT OF PUTATIVE METABOLITE IDS VIA A PROBABILISTIC MODEL. AIM 2 WILL ASSEMBLE THE TOOLS DEVELOPED IN AIM 1 INTO A CLOUD-BASED PLATFORM, METABOQUEST, WHICH PROVIDES USERS WITH INTERACTIVE VISUALIZATION OF PEAKS, ISOTOPIC PATTERNS, NETWORKS, AND MASS SPECTRA. FURTHERMORE, AIM 2 WILL FOCUS ON INTEGRATING INTO METABOQUEST A PIPELINE BUILDER THAT ALLOWS USERS TO CREATE PIPELINES BY LINKING MODULES AND RUN THEM REMOTELY THROUGH A MODULAR INTERACTIVE WEB INTERFACE. AIM 3 WILL PERFORM A COMPREHENSIVE EVALUATION OF METABOQUEST IN TERMS OF METABOLITE ANNOTATION ACCURACY, NUMBER OF ANNOTATED METABOLITES, AND COMPUTATIONAL EFFICIENCY COMPARED TO OTHER EXISTING TOOLS. ACCURACY IN METABOLITE ANNOTATION WILL BE EVALUATED VIA EXPERIMENTAL METHODS IN WHICH MS/MS DATA FROM UNKNOWN ANALYTES AND REFERENCE COMPOUNDS ARE COMPARED, AND BY USING LC-MS/MS DATA FROM MULTIPLE METABOLOMICS STUDIES THAT CONSIST OF GROUND-TRUTH INFORMATION. SUCCESSFUL IMPLEMENTATION AND VALIDATION OF METABOQUEST WILL CONTRIBUTE TO ADDRESSING THE MAJOR BOTTLENECK IN METABOLOMICS - METABOLITE IDENTIFICATION, THEREBY ELIMINATING THE NEED FOR MANUAL VERIFICATION OF PUTATIVE METABOLITE IDS AND ENHANCING THE CONTRIBUTION OF METABOLOMICS STUDIES, SPECIFICALLY IN DISEASE BIOMARKER AND DRUG DISCOVERY.

STATE TRAFFIC SAFETY INFORMATION SYSTEM IMPROVEMENT GRANTS SEC 408

ENHANCED AEROMECHANICAL LOAD AND STRESS ASSESSMENT

IMPLEMENT THE PROJECT: MAPPING ILLICIT SUPPLY NETWORKS TO COMBAT CONSERVATION CRIMES AT THEIR CONVERGENCE.

SECTION 402 STATE AND COMMUNITY HIGHWAY SAFETY GRANT (23 C.F.R. SUBPART B TO PART 1300; 23 U.S.C. & 402) - GRANT TO CONDUCT HIGHWAY SAFETY PROGRAMS UNDER THE STATE'S APPROVED HIGHWAY SAFETY PLAN.

SAFE AND DRUG-FREE SCHOOLS AND COMMUNITIES - NATIONAL PROGRAMS - SAFE SCHOOLS/HEALTHY STUDENTS GRANTS

NEXT GENERATION BIPOLAR PLATES FOR AUTOMOTIVE PEM FUEL CELLS

SECTION 402 STATE AND COMMUNITY HIGHWAY SAFETY GRANT

SECTION 410 ALCOHOL TRAFFIC SAFETY AND DRUNK DRIVING PREVENTION INCENTIVE GRANTS

SECTION 402 STATE AND COMMUNITY HIGHWAY SAFETY GRANTS

SECTION 405(I) DRIVER AND OFFICER SAFETY EDUCATION GRANT (23 C.F.R.� 1300.28; 23 U.S.C.� 405(I)) - GRANT TO SUPPORT EDUCATION AND TRAINING PROGRAMS ON LAW ENFORCEMENT PRACTICES DURING TRAFFIC STOPS IN DRIVER EDUCATION AND TRAINING COURSES OR PEACE OFFICER TRAINING PROGRAMS CONSISTENT WITH 23 C.F.R.� 1300.28(H).