Ase Incorporated

CATEGORY C: COMMUNITY-BASED ORGANIZATIONS

RAPID EXP. OF ART FOR HIV-INFECTED PERSONS IN SELECTED COUNTRIES FOR PEPFAR

2010 TANF

2009 TANF

PREVENTIVE HEALTH AND HEALTH SERVICES - STRENGTHENING PUBLIC HEALTH SYSTEMS AND SERVICES THROUGH NATIONAL PARTNERSHIPS TO IMPROVE AND PROTECT THE NATION'S HEALTH

ACCELERATING EPIDEMIC CONTROL IN KAMPALA REGION OF UGANDA THROUGH SCALE UP OF EVIDENCE BASED AND HIGH IMPACT INTERVENTIONS TOWARDS ACHIEVEMENT OF UNAIDS 90:90:90 TARGETS.

SUPPORTING SUSTAINABLE IMPLEMENTATION OF HIV AND TB SERVICES FOR EPIDEMIC CONTROL IN THE REPUBLIC OF

PEPFAR CARE AND TREATMENT

CAPACITY BUILDING AND STRENGTHENING IMPLEMENTATION OF HIV COMBINATION PREVENTION AND TREATMENT SERVI

CASE COMPREHENSIVE CANCER CENTER SUPPORT GRANT

TRANSITION TO LOCAL OWNERSHIP AND INTEGRATION OF HIV PROGRAMS IN PRIMARY HEALTH C

VICTORIA AIMS TO BUILD ON THE ACHIEVEMENTS OF ESPERANCA AND THE ACTIVITIES PRESENTED ARE GROUNDED IN A STRENGTHENED CONVENTIONAL HEALTH SYSTEM COMPLEMENTED BY AN EQUALLY ROBUST COMMUNITY SUB-SYSTEM.

USAID REGIONAL HEALTH INTEGRATION TO ENHANCE SERVICES IN SOUTH WEST UGANDA

PROVISION OF COMPREHENSIVE HIV CARE, TREATMENT, AND SUPPORT PROGRAMS IN THE UNITED REPUBLIC OF TANZA

RECOVERY ACT - PENNSYLVANIA RESEARCH AND EDUCATION NETWORK (PENNREN)

SUPPORTING IMPLEMENTATION OF HIV AND TB SERVICES FOR EPIDEMIC CONTROL IN THE REPUBLIC OF MOZAMBIQUE

ACHIEVING HIV EPIDEMIC CONTROL THROUGH SCALING UP QUALITY TESTING, CARE AND TREATMENT IN MALAWI UNDE

GRANT

ELIZABETH GLASER PEDIATRIC AIDS FOUNDATION - PROJECT ALCANCAR - ADVANCING SUSTAINABLE IMPLEMENTATION OF COMPREHENSIVE HIV/TB SERVICES FOR EPIDEMIC CONTROL IN MOZAMBIQUE - AS A FOLLOW-ON OF THE PREVIOUS ESCALA PROJECT, THROUGH PROJECT ALCANAR, EGPAF WILL PROVIDEDIRECT SUPPORT FOR COMPREHENSIVE AND EVIDENCE-BASED PREVENTION, CARE, SUPPORT AND TREATMENT INTERVENTIONS WITHIN HIV AND TB FACILITIES AND COMMUNITIES. THIS INCLUDES, BUT IS NOT LIMITED TO, THE FOLLOWING CROSS-CUTTING AREAS: HRH, GBV, CECAP, PREVENTION OF VERTICAL TRANSMISSION OF HIV (PMTCT), SYPHILIS AND HEPATITIS B (HBV), PHARMACY, LABORATORY, SURVEILLANCE AND SURVEYS, HEALTH SYSTEMS STRENGTHENING, HEALTH ECONOMICS, HEALTH COMMUNICATION, SEXUAL PREVENTION, EPIDEMIOLOGIC ASSISTANCE, DQA, MONITORING AND EVALUATION (M&E), INFORMATION SYSTEMS, AND IMPACT AND PROGRAM EVALUATION.EGPAF WILLPROVIDE SUPPORT TO MOZAMBIQUE GOVERNMENTAL INSTITUTIONS AND OTHER STAKEHOLDERS/PARTNERS INVOLVED IN PROVIDING HIV AND TB SERVICES INGAZA AND INHAMBANE.EGPAFWILL TO WORK AT NATIONAL, PROVINCIAL, DISTRICT, AND SUB-DISTRICT LEVELS.

EPIDEMIOLOGY OF DIABETES INTERVENTIONS AND COMPLICATIONS (EDIC)

GH11-11108 TECH ASSIST TO THE MOH FOR HIV SVC & PROG TRANS(FORTALECER PROJECT)

BSL 1 INDUSTRIAL BASE EXPANSION COOPERATIVE AGREEMENT TO GRAND RIVER ASEPTIC MANUFACTURING INC. (GRAM)

PARTNERING WITH NATIONAL ORGANIZATIONS TO SUPPORT COMMUNITY-BASED ORGANIZATIONS TO INCREASE VACCINATION COVERAGE ACROSS DIFFERENT RACIAL AND ETHNIC ADULT POPULATIONS CURRENTLY EXPERIENCING DISPARITIES - THE CDC FOUNDATION WILL SUPPORT EFFORTS TO INCREASE ACCESS AND ACCEPTANCE OF INFLUENZA AND COVID-19 VACCINES AMONG ADULTS IN RACIAL AND/OR ETHNIC POPULATIONS EXPERIENCING DISPARITIES IN THE UNITED STATES. THE CDC FOUNDATION WILL USE THREE MAIN STRATEGIES TO ACHIEVE THIS GOAL: 1) FUND COMMUNITY-BASED ORGANIZATIONS (CBOS) TO ENGAGE AND BUILD TRUST WITH TARGET COMMUNITIES, 2) BUILD THE CAPACITY OF CBOS TO IMPLEMENT AND EVALUATE SUCCESSFUL COMMUNITY INTERVENTIONS WITH A HEALTH EQUITY FOCUS, AND 3) SUPPORT EFFECTIVE PARTNERSHIPS AND THE DISSEMINATION OF TOOLS, RESOURCES AND BEST-PRACTICES THROUGH THE CREATION OF A RESOURCE HUB.BY BUILDING THE CAPACITY AND RESILIENCY OF CBOS THROUGH PARTNERSHIPS AND RESOURCE SHARING, THE CDC FOUNDATION WILL EXPAND THE IMPLEMENTATION OF EVIDENCE-BASED INTERVENTIONS TO ADDRESS VACCINE MISINFORMATION, EXPAND VACCINE OPPORTUNITIES AND INCREASE VACCINE COVERAGE. THE CDC FOUNDATION WILL OVERSEE THE DESIGN, DEVELOPMENT, AND MANAGEMENT OF A SEARCHABLE REPOSITORY PLATFORM TO HOUSE A MULTI-LINGUAL INVENTORY OF COMMUNICATION MATERIALS AND TOOLS TO SUPPORT COLLABORATIVE EFFORTS TO INCREASE ADULT IMMUNIZATION. THE CDC FOUNDATION WILL FACILITATE CBO NETWORKING, PROVIDE LINKAGES TO TECHNICAL ASSISTANCE AND SUBJECT MATTER EXPERTS, AND BUILD THE CAPACITY OF CBOS. THE CDC FOUNDATION FULLY EMBRACES CDC?S STRATEGY TO ADDRESS DISPARITIES IN INFLUENZA AND COVID-19 VACCINATION RATES BASED ON RACE AND ETHNICITY. BY THE END OF THE PROJECT, CBOS WILL HAVE INCREASED CAPABILITIES AND ACCESS TO COMMUNICATION MATERIALS TO BETTER ADDRESS VACCINE HESITANCY AND HEALTH INEQUITIES AMONG BLACK, INDIGENOUS AND PEOPLE OF COLOR (BIPOC) COMMUNITIES. AN EXPECTED PROJECT OUTCOME IS TO STRENGTHEN AUTHENTIC, COMMUNITY DIALOGUE THROUGH CBO ENGAGEMENT ACTIVITIES THAT ADDRESS VACCINE MISINFORMATION AND SUPPORT INDIVIDUALS IN OPENLY WEIGHING AVAILABLE OPTIONS, RISKS, AND BENEFITS ? AT BOTH A PERSONAL AND A COMMUNITY LEVEL, ALONG WITH HOW THEIR LIVED EXPERIENCE FAC TORS INTO THESE DECISIONS. THIS PROJECT WILL SIGNIFICANTLY INCREASE THE NUMBER OF CBOS ENGAGED IN PUBLIC HEALTH AND VACCINE EDUCATION AND DELIVERY. ANOTHER IMPORTANT OUTCOME WILL BE AN INCREASE IN THE KNOWLEDGE, ENGAGEMENT, VACCINE CONFIDENCE AND ACCEPTANCE RATES IN TARGET BIPOC COMMUNITIES. THE PROJECT WILL ASSESS THE DIFFERENT CBO STRATEGIES, ACTIVITIES, AND RESULTS TO PROVIDE FINDINGS AND RECOMMENDATIONS FOR INCREASING VACCINE ACCEPTANCE AMONG AT-RISK POPULATIONS.

2010 CCDF

2009 CCDF

2009 LIHEAP

SUPPORTING THE IMPLEMENTATION AND EXPANSION OF HIGH QUALITY, SUSTAINABLE AND COMPREHENSIVE HIVPREVENTION, CARE AND TREATMENT PROGRAMS IN THE WESTERN

2010 LIHEAP

SPECIAL SUPPLEMENTAL NUTRITION PROGRAM FOR WOMEN, INFANTS, AND CHILDREN

EGPAF: CDC-RFA-GH19-1916: DEVELOP, IMPLEMENT, AND SUSTAIN HIGH QUALITY COMPREHENSIVE HIV CASCADE ACTIVITIES FOR CHILDREN, ADOLESCENTS, AND ADULTS IN FACILITY AND COMMUNITY BASED SETTINGS IN CAMEROON

2011 LIHEAP

SPECIAL SUPPLEMENTAL NUTRITION PROGRAM FOR WOMEN, INFANTS, AND CHILDREN

GH11-1130 SUPPORT INDIGENOUS ORG. TO IMPLEMENT & EXPAND HIV/AIDS PREVENTION, CARE

SPECIAL SUPPLEMENTAL NUTRITION PROGRAM FOR WOMEN, INFANTS, AND CHILDREN

THE PURPOSE OF THIS PROJECT IS TO IMPROVE THE TB CARE (E.G. PREVENTION OF TB, BETTER CASE DETECTION, DIAGNOSIS, PROMPT TREATMENT, IMPROVED TREATMENT OUTCOMES, STRONG REFERRAL NETWORK, ACTIVE MONITORING, AND REPORTING OF ALL FORMS OF TB) IN THE SELECTED GEOGRAPHIC AREAS OF BANGLADESH. THE ACTIVITY WILL ALSO ENSURE BETTER ENGAGEMENT OF THE PRIVATE SECTOR AND COORDINATION WITH THE EXISTING USAID FUNDED ACTIVITIES AND GLOBAL FUND ACTIVITIES.

EGPAF ACCELERATING LESOTHO'S PROGRESS TO EPIDEMIC CONTROL THROUGH HEALTH SYSTEM STRENGTHENING AND DELIVERY OF COMPREHENSIVE HIV/TB CARE, TREATMENT AND PREVENTION SERVICES UNDER PEPFAR - WITH PARTNERS BAYLOR, LENEPWHA , AND SENTEBALE, EGPAF IS IMPLEMENTING THE ALPEC PROJECT. EGPAF AND OUR PARTNERS COLLABORATE WITH COUNTERPARTS AND STAKEHOLDERS FROM THE MOH, CHAL, PEPFAR IMPLEMENTING PARTNERS, LOCAL CIVIL SOCIETY ORGANIZATIONS, AND LOCAL STRUCTURES. THE PURPOSE OF THE PROJECT IS TO EXPAND SUPPORT FOR THE PROVISION OF SCALABLE, HIGH QUALITY, COMPREHENSIVE, EVIDENCE BASED HIV AND TB PREVENTION, CARE, AND TREATMENT THROUGHOUT FOUR DISTRICTS IN LESOTHO. THE OVERALL AIM IS TO ASSIST THE GOL TO ATTAIN AND SUSTAIN HIV EPIDEMIC CONTROL. THE ULTIMATE GOAL IS TO DECREASE HIV AND TB INCIDENCE, AND HIV AND TB ASSOCIATED MORBIDITY AND MORTALITY AMONG ALL POPULATIONS IN LESOTHO. ALPEC'S APPROACH WILL IDENTIFY SYSTEM BARRIERS AND BOTTLENECKS AFFECTING EFFORTS TO REACH THE UNAIDS 95 95 95 TARGETS, AND DEVELOP STRATEGIES TO ADDRESS THEM.

THE LIFE PROGRAM

ACHIEVING AND SUSTAINING HIV AND TB EPIDEMIC CONTROL IN KAMPALA REGION OF UGANDA THROUGH SCALE UP OF INNOVATIVE EVIDENCE - BASED INTERVENTIONS TOWARDS ACHIEVEMENT OF UNAIDS 95:95:95 TARGETS.

FY 2010 FOSTER CARE

PROVINCIAL OWNERSHIP TO UPLIFT DELIVERY OF HIV/TB SERVICES IN ZAMBIA (PROUD-Z) THROUGH TECHNICAL ASSISTANCE

ELIZABETH GLASER PEDIATRIC AIDS FOUNDATION - SCORE95 - SUSTAINING HIV EPIDEMIC CONTROL THROUGH EFFICIENT CASE FINDING AND QUALITY CARE AND TREATMENT SERVICES IN MALAWI UNDER PEPFAR - THE ELIZABETH GLASER PEDIATRIC AIDS FOUNDATION (EGPAF) IS PLEASED TO PRESENT THE SUSTAINING CONTROL OF THE HIV EPIDEMIC THROUGH EFFICIENT CASE FINDING AND QUALITY CARE AND TREATMENT SERVICES IN MALAWI PROJECT (SCORE95) IN PARTNERSHIP WITH MALAWI AIDS COUNSELING AND RESOURCE ORGANIZATION (MACRO), IN RESPONSE TO THE U.S. CENTERS FOR DISEASE CONTROL AND PREVENTION’S (CDC) SUSTAINING HIV EPIDEMIC CONTROL THROUGH EFFICIENT CASE FINDING AND QUALITY CARE AND TREATMENT SERVICES IN MALAWI UNDER THE PEPFAR. WITH NEARLY 50 YEARS OF COMBINED EXPERIENCE COMBATTING MALAWI’S HIV EPIDEMIC, EGPAF AND LOCAL PARTNER MACRO WILL LEVERAGE THEIR IN-DEPTH KNOWLEDGE OF THE HIV EPIDEMIC IN MALAWI, DEMONSTRATED IN-COUNTRY IMPACT, STRONG RELATIONSHIPS WITH LOCAL STAKEHOLDERS, WELL-ESTABLISHED LOCAL INFRASTRUCTURE, RENOWNED TECHNICAL ASSISTANCE AND LOCAL TRANSITION MODELS, AND RECOGNIZED EXPERTISE IN HIV PREVENTION, CARE, AND TREATMENT TO CAPACITATE MALAWI’S HEALTH SYSTEM TO SUSTAIN PROGRESS AGAINST THE 95-95-95 TARGETS. SCORE95 WILL DELIVER PATIENT-CENTERED HIV PREVENTION, CARE, AND TREATMENT SERVICES, AND TARGETED TECHNICAL ASSISTANCE TO ENABLE LOCAL GOVERNMENT INSTITUTIONS AND ORGANIZATIONS TO SUSTAIN EPIDEMIC CONTROL AT THE COMMUNITY, DISTRICT, AND NATIONAL LEVELS. CONCERTED EFFORTS TO REACH POPULATIONS WHO HAVE FALLEN THROUGH THE GAPS WITH REGARDS TO PREVENTION, TESTING, AND LINKAGE TO SERVICES WILL BE ACCELERATED THROUGH COMBINING PROVEN DIRECT SERVICE DELIVERY STRATEGIES AND TAILORED TECHNICAL ASSISTANCE APPROACHES THAT BUILD LOCAL CAPABILITIES AND INFRASTRUCTURE. EGPAF AND MACRO’S DEEP KNOWLEDGE OF THE UNIQUE NEEDS AND CHALLENGES OF EACH DISTRICT IN MALAWI, COMBINED WITH EXTENSIVE TECHNICAL EXPERTISE, AND STRATEGIC USE OF GRANULAR DATA AND RAPID EVALUATION CYCLE SYSTEMS THAT DRIVE SCALED IMPLEMENTATION AND INFORM CONTINUOUS QUALITY IMPROVEMENT, WILL ALLOW US TO BUILD ON SUCCESSES UNDER OUR CURRENT PIVOT 2 PROJECT AND ROLL-OUT PHASED TRANSITION PLANS WITH THE MINISTRY OF HEALTH (MOH) AND CDC THAT FACILITATE IN-COUNTRY OWNERSHIP OF HIV PROGRAMMING. EGPAF WILL AMPLIFY AND TRANSITION OUR DATA-DRIVEN AND COST-EFFICIENT APPROACHES TO ENSURE PATIENT-CENTERED SERVICES ARE DELIVERED BY OPTIMIZED AND TRAINED MOH HEALTH CARE TEAMS TO END HIV. EGPAF AND MACRO WILL PARTNER WITH THE MOH TO IMPLEMENT PROVEN STRATEGIES TO IDENTIFY AND SERVE HARD TO REACH KEY POPULATIONS THROUGH A COMBINATION OF COMMUNITY AND FACILITY LEVEL INTERVENTIONS THAT ARE CLIENT-CENTERED AND PATIENT-PREFERRED. CONTINUED IMPLEMENTATION, REFINEMENT, AND DEVELOPMENT OF DIFFERENTIATED SERVICE DELIVERY MODELS IS A CENTRAL APPROACH UNDER SCORE95, AS IS THE INTRODUCTION OF NEW INNOVATIONS, INCLUDING OPTIMIZED TREATMENT REGIMENS AND BIOMEDICAL OPTIONS FOR PREVENTION, THAT ARE APPROPRIATE FOR RESPONSE TO MALAWI’S EPIDEMIC. THE CAPACITY OF DISTRICT EXECUTIVE COUNCILS, DISTRICT MANAGEMENT HEALTH TEAMS, AND HEALTH CARE WORKERS WILL BE STRENGTHENED VIA TARGETED, ONGOING TRAINING AND SECONDING TEAMS OF TECHNICAL EXPERTS TO THE MOH TO PROVIDE TAILORED IN-PERSON AND VIRTUAL MENTORSHIP. EGPAF WILL ALSO EXPAND THE CAPACITY OF MACRO FROM HIV TESTING SERVICES (HTS) DELIVERY TO BECOME A COMPREHENSIVE CLINICAL SERVICE PROVIDER ACROSS THE HIV CONTINUUM OF CARE. ADDITIONALLY, SCORE95 FOCUSES ON FURTHER OPTIMIZATION OF HUMAN RESOURCES FOR HEALTH, BOLSTERING EGPAF’S SUCCESS IN SECONDING CLINICAL STAFF TO HIGH-VOLUME CLINICS TO PROMOTE CONTINUOUS PATIENT CARE, AND COLLABORATING WITH THE MOH AND CDC PARTNERS TO ENSURE THE MOST EFFECTIVE USE OF HUMAN RESOURCES FOR HEALTH (HRH) INVESTMENTS TO SUSTAIN EPIDEMIC CONTROL. AT THE NATIONAL LEVEL, EGPAF WILL PROVIDE TARGETED TECHNICAL ASSISTANCE TO MOH DEPARTMENTS AND DISTRICT MANAGERIAL TEAMS TO CONTINUE TO STRENGTHEN TECHNICAL, PROGRAMMATIC, AND DATA USE CAPABILITIES AS PART OF THE TRANSITION T

FY 2009 FOSTER CARE

CLINICAL AND TRANSLATIONAL SCIENCE COLLABORATIVE OF CLEVELAND

ACCELERATING COMPREHENSIVE HIV/AIDS SERVICE DELIVERY THROUGH HEALTH SYSTEMS CAPACITY BUILDING AND TECHNICAL ASSISTANCE TO DISTRICT HEALTH TEAMS AND HEALTH FACILITIES IN WESTERN AND WEST-NILE

GH20-2081: EGPAF APPLICATION FOR INNOVATIVE SYSTEMS AND TECHNOLOGIES IN MALAWI

EGPAF: CDC-RFA-GH17-1756 - THE DJASSO PROJECT

2012 LIHEAP

FY 2010 ADOPTION ASSISTANCE

FY 2013 ADOPTION ASSISTANCE

PS10-10128, HIV CARE, SUPPORT AND TREATMENT: IMPLEMENTATION

CATEGORY A: STATE HEALTH DEPARTMENTS - NONCOMMUNICABLE DISEASES (NCD), ALSO KNOWN AS CHRONIC DISEASES, ARE THE LEADING CAUSES OF DEATH AND DISABILITY IN THE UNITED STATES. THESE CONDITIONS ACCRUE MORE THAN $4.1 TRILLION IN ANNUAL HEALTHCARE COSTS AND HAVE DISPARATE IMPACTS ON RACIALLY AND ECONOMICALLY OPPRESSED PEOPLE. LIMITATIONS IN THE TIMELINESS AND GRANULARITY OF AVAILABLE SURVEILLANCE DATA HINDER EFFORTS TO UNDERSTAND AND ADDRESS THESE HEALTH DISPARITIES AT A POPULATION LEVEL. INTEGRATING MULTIPLE PARTNERSHIPS AND DATA SYSTEMS INTO COHESIVE, MODERN PUBLIC HEALTH SYSTEMS REQUIRES TECHNICAL CAPACITY, DATA GOVERNANCE STRUCTURES, AND SUPPORT FOR COLLABORATION THAT ARE OFTEN UNAVAILABLE IN UNDERSTAFFED AND UNDERFUNDED HEALTH DEPARTMENTS. HOWEVER, WITH THESE SUPPORTS, STATE HEALTH DEPARTMENTS (SHD) CAN BE COLLABORATIVE INCUBATORS FOR DEVELOPING CREATIVE APPROACHES TO DATA MODERNIZATION THAT COULD INFORM AND ACCELERATE NATIONAL EFFORTS TO IMPROVE PUBLIC HEALTH PERFORMANCE AND OUTCOMES. THE NATIONAL ASSOCIATION OF CHRONIC DISEASE DIRECTORS (NACDD) WORKS TO IMPROVE THE HEALTH OF THE PUBLIC BY STRENGTHENING STATE-BASED LEADERSHIP AND EXPERTISE FOR CHRONIC DISEASE PREVENTION AND CONTROL IN STATES AND AT THE NATIONAL LEVEL. THIS PROJECT WILL USE NACDD’S 36 YEARS OF EXPERIENCE TO INCREASE STATE CAPACITY TO IMPLEMENT AND USE MODERN DATA SYSTEMS APPROACHES TO NCD SURVEILLANCE. NACDD PROPOSES TO ENGAGE SHDS AS A POPULATION OF FOCUS IN CAPACITY-BUILDING ASSISTANCE (CBA) ACTIVITIES DESIGNED TO FOSTER AND DISSEMINATE CREATIVE APPROACHES TO DATA MODERNIZATION AND NCD SURVEILLANCE. NACDD WILL OFFER THREE LEVELS OF CBA THAT ADDRESS SHDS’ EXPRESSED NEEDS FOR TECHNICAL AND STRUCTURAL SUPPORT FOR DATA MODERNIZATION: 1. ACTION INCUBATORS: SMALL GROUP, ACTION-ORIENTED, EXPERIENTIAL OPPORTUNITIES TO DEVELOP INNOVATIVE SOLUTIONS AND ENGAGE IN PEER-TO-PEER SUPPORT AND SHARED LEARNING 2. COHORT COURSES: SMALL-TO-MEDIUM-SIZED GROUP OPPORTUNITIES TO LEARN DATA MODERNIZATION TECHNICAL SKILLS, DISCOVER PROMISING NEW PRACTICES, AND NETWORK WITH PEERS 3. WORKSHOPS AND WEBINARS: LARGE GROUP LEARNING OPPORTUNITIES OPEN TO ALL NACDD MEMBERS WHERE PROMISING DATA MODERNIZATION PRACTICES CAN BE DISSEMINATED TO INFORM NATIONAL AND STATE DATA MODERNIZATION WORK THIS WORK WILL COLLECTIVELY IMPROVE SHD'S ORGANIZATIONAL CAPACITY TO MODERNIZE NCD SURVEILLANCE THROUGH INCREASED ACCESS TO CBA THAT SUPPORTS INNOVATION, PEER-TO-PEER SUPPORT, AND SHARED LEARNING. IN ADDITION, BECAUSE ACCESS TO TIMELY, LOCAL, AND REPRESENTATIVE NCD SURVEILLANCE DATA IS A BARRIER TO UNDERSTANDING AND ADDRESSING HEALTH DISPARITIES, INCREASED NCD CAPACITY WILL BENEFIT THE LONG-TERM GOAL OF IMPROVING HEALTH EQUITY. NACDD’S MULTIFACETED, ACTION-ORIENTED APPROACH PROVIDES RESOURCES AND TECHNICAL SUPPORT TO BRIDGE CURRENT CAPACITY TO THE FUTURE OF NCD SURVEILLANCE. NACDD’S PROPOSED STRATEGIES, ACTIVITIES, AND EVALUATION EFFORTS WILL STRENGTHEN SHD NCD SURVEILLANCE CAPABILITIES AND INFRASTRUCTURE BY INCUBATING CREATIVE APPROACHES AND FACILITATING KNOWLEDGE CAPTURE AND SHARING. THESE EFFORTS WILL INFORM NATIONAL DATA MODERNIZATION AND ENHANCE STATE CAPACITY TO ADDRESS HEALTH DISPARITIES THROUGH EVIDENCE-BASED POLICIES AND PROGRAMS.

FY 2011 ADOPTION ASSISTANCE

FY 2012 ADOPTION ASSISTANCE

2013 LIHEAP

CASE WESTERN RESERVE UNIVERSITY/CLEVELAND CLINIC CTSA (UL1)

STRENGTHENING COORDINATION & DEVELOP OF HIV/AIDS PREV & CARE IN THE SOCIALIST REP

FY 2009 ADOPTION ASSISTANCE

2010 TANFS

FY 2013 FOSTER CARE

GH18-1832, ENTITLED SUPPORTING LOCAL INDIGENOUS ORGANIZATIONS IN THE IMPLEMENTATION OF PROGRAMS FOR THE PREVENTION, CARE AND TREATMENT OF HIV/AIDS IN THE REPUBLIC OF COTED'IVOIRE UNDER THE PRESIDENT'S EMERGENCY PLAN FOR AIDS RELIEF (PEPFAR)

STATE ADMINISTRATIVE MATCHING GRANTS FOR SUPPLEMENTAL NUTRITION ASSISTANCE PROGRAM

STATE ADMINISTRATIVE MATCHING GRANTS FOR SUPPLEMENTAL NUTRITION ASSISTANCE PROGRAM

CASE AIDS CLINICAL TRIALS UNIT

ELIZABETH GLASER PEDIATRIC AIDS FOUNDATION - IMPLEMENTATION OF COMPREHENSIVE PROGRAMS FOR THE PREVENTION, CARE, AND TREATMENT OF HIV/AIDS IN THE REPUBLIC OF COTE D'IVOIRE UNDER PEPFAR - THE ELIZABETH GLASER PEDIATRIC AIDS FOUNDATION (EGPAF) IS PLEASED TO PRESENT OUR APPROACH FOR THE U.S. CENTERS FOR DISEASE CONTROL AND PREVENTION’S (CDC) IMPLEMENTATION OF COMPREHENSIVE PROGRAMS FOR THE PREVENTION, CARE, AND TREATMENT OF HIV/AIDS IN THE REPUBLIC OF CÔTE D’IVOIRE UNDER THE PRESIDENT’S EMERGENCY PLAN FOR AIDS RELIEF (PEPFAR) (SOLICITATION NUMBER CDC-RFA-GH22-2237). EGPAF WILL LEVERAGE ITS IN-DEPTH KNOWLEDGE OF THE HIV EPIDEMIC IN CÔTE D’IVOIRE, STRONG RELATIONSHIPS AND COLLABORATIONS WITH IN-COUNTRY STAKEHOLDERS, AND RECOGNIZED EXPERTISE IN HIV PREVENTION, CARE, AND TREATMENT TO REACH AND SUSTAIN THE UNAIDS 95-95-95 TARGETS. EGPAF, IN PARTNERSHIP WITH HEARTLAND ALLIANCE CÔTE D’IVOIRE (HACI) AND CENTRE SOLIDARITE ACTION SOCIALE (CSAS), WILL INCREASE THE SUSTAINABILITY OF CÔTE D’IVOIRE’S HIV/AIDS RESPONSE THROUGH PROVISION OF COMPREHENSIVE HIV PREVENTION, CARE, AND TREATMENT SERVICES, AND TECHNICAL ASSISTANCE (TA) TO THE MINISTRY OF HEALTH, PUBLIC HYGIENE, AND UNIVERSAL HEALTH PROTECTION (MSHPCMU), REGIONAL AND DISTRICT HEALTH MANAGEMENT TEAMS, AND LOCAL COMMUNITY-BASED ORGANIZATIONS AND FACILITIES TO DELIVER QUALITY HIV/AIDS SERVICES AND SUSTAIN EPIDEMIC CONTROL. EGPAF WILL PROVIDE LEADERSHIP AND SUPPORT TO ACTIVITIES ACROSS ALL PROGRAM AREAS THROUGH DIRECT SERVICE DELIVERY AND TA. HACI WILL OFFER KEY POPULATION SPECIFIC SERVICES, INCLUDING DEMAND CREATION FOR HIV SERVICES; COMMUNITY COUNSELLING, TESTING, AND TREATMENT REFERRAL; GENDER-BASED VIOLENCE; SCREENING AND RESPONSE; AND PSYCHOSOCIAL SUPPORT. CSAS WILL SUPPORT DELIVERY OF HIV AND OTHER HEALTH SERVICES, AS WELL AS ECONOMIC STRENGTHENING, TARGETING ADOLESCENT GIRLS AND YOUNG WOMEN (AGYW) AND ORPHANS AND VULNERABLE CHILDREN (OVC) BENEFICIARIES. THE PROJECT WILL IMPLEMENT STRATEGIC ACTIVITIES IN ALIGNMENT WITH FOUR CROSS-CUTTING APPROACHES: IMPLEMENT COORDINATED FACILITY- AND COMMUNITY-BASED STRATEGIES TO DELIVERY HIGH-QUALITY SERVICES TO TARGET POPULATIONS; GENERATE AND USE HIGH QUALITY DATA AND A ROBUST QUALITY IMPROVEMENT (QI) APPROACH; BUILD CAPACITY OF THE MSHPCMU AND LOCAL ORGANIZATIONS TO ENSURE THE SUCCESSFUL TRANSITION OF PREVENTION, CARE, AND TREATMENT SERVICES; AND PROMOTE PERSON-CENTERED AND INNOVATIVE INTERVENTIONS TO MITIGATE BARRIERS TO SERVICE DELIVERY. THE PROJECT WILL BE LED BY EGPAF’S HIGHLY RESPECTED LEADERSHIP TEAM. COUNTRY DIRECTOR/PRINCIPAL INVESTIGATOR DR. CHARLES JOSEPH DIBY WILL PROVIDE STRATEGIC AND MANAGERIAL LEADERSHIP AS THE PRIMARY POINT OF CONTACT FOR CDC, THE MSHPCMU, AND OTHER STAKEHOLDERS, BUILDING ON HIS EXPERIENCE LEADING THE CURRENT PROJECT DJASSO. TECHNICAL DIRECTOR DR. KOUADIO MARC N’GORAN WILL ENSURE THE IMPLEMENTATION OF HIGH-QUALITY HIV/AIDS INTERVENTIONS WITH FIDELITY, OVERSEE EFFORTS TO STRENGTHEN COMMUNITY-FACILITY LINKAGES, AND LEAD TRAINING AND CAPACITY BUILDING ACTIVITIES. STRATEGIC INFORMATION DIRECTOR N’DA N’GUESSAN JEAN-PAUL KOUADIO WILL OVERSEE THE PROJECT’S STRATEGIC INFORMATION AND EVALUATION (SI&E) PROGRAM, INCLUDING MONITORING AND EVALUATION (M&E), INFORMATICS, AND DATA USE. FINANCE DIRECTOR ALFRED ZIE OUATTARA WILL OVERSEE PROJECT FINANCES, SUB-AWARDS, AND ADMINISTRATION, INCLUDING BUDGET OVERSIGHT, PROCUREMENT, AND REPORTING TO CDC. THEY WILL BE SUPPORTED BY EXISTING EGPAF STAFF, 100% OF WHOM ARE IVOIRIAN AND SPEAK FRENCH AND LOCAL LANGUAGES. A KEY PARTNER IN CÔTE D’IVOIRE SINCE 2004, EGPAF WAS THE FIRST ORGANIZATION TO SUPPORT THE SCALE-UP OF PREVENTION OF MOTHER-TO-CHILD TRANSMISSION (PMTCT) IN COUNTRY, AND HAS BEEN A TRUSTED PARTNER TO THE MSHPCMU AT EACH STAGE OF THE HIV RESPONSE. TOGETHER, THE PROJECT TEAMS’ EXPERIENCE AND FAMILIARITY WITH THE IVOIRIAN CONTEXT, DEPTH OF EXPERTISE, AND ABILITY TO DRAW ON TOOLS AND BEST PRACTICES FROM CÔTE D’IVOIRE AND GLOBALLY MAKE US UNIQUELY QUALIFIED TO ACHIEVE THE PROJECT GOAL.

TUNAWEZA

STATE ADMINISTRATIVE MATCHING GRANTS FOR SUPPLEMENTAL NUTRITION ASSISTANCE PROGRAM

STATE ADMINISTRATIVE MATCHING GRANTS FOR SUPPLEMENTAL NUTRITION ASSISTANCE PROGRAM

FY 2012 FOSTER CARE

SUPPORTING THE IMPLEMENTATION AND EXPANSION OF HIGH QUALITY HIV PREVENTION CARE

GH15-1548, LESOTHO: SUPPORTING HIV AND TUBERCULOSIS RESPONSE THROUGH DISTRICT-BASED COMPREHENSIVE PREVENTION, CARE AND TREATMENT PROGRAMS AND HEALTH

COVID-19 ACTION. NEW COOPERATIVE AGREEMENT FOR THE EXPANSION OF GRAND RIVER ASEPTIC MANUFACTURING, INC. (GRAM) DOMESTIC ASEPTIC FILL/FINISH CAPACITY TO MEET THE UNITED STATES GOVERNMENT (USG) REQUIREMENTS OF BEING ABLE TO FILL A BROAD RANGE OF VACCINES AND ESSENTIAL MEDICINES RAPIDLY

SERVICE DELIVERY FOR HIV PREVENTION (SDHP): THE ACTIVITY SEEKS TO IMPROVE THE HEALTH OUTCOMES OF ZAMBIANS BY PREVENTING NEW HIV INFECTIONS AMONG POPULATIONS MOST AT RISK OF ACQUIRING HIV.

SCALING UP LABORATORY SERVICES TO PROVIDE HIGH QUALITY HIV DIAGNOSIS, CARE, TREATMENT, AND MONITORING TOWARDS THE ACHIEVEMENT OF THE 90-90-90 GOALS IN ZAMBIA UNDER PEPFAR.

2011 OCSE

STATE ADMINISTRATIVE MATCHING GRANTS FOR SUPPLEMENTAL NUTRITION ASSISTANCE PROGRAM

SCALING UP COMPREHENSIVE HIV/AIDS SERVICES INCLUDING

SUPPORTING LOCAL ORGANIZATIONS TO IMPLEMENT AND EXPAND COMPREHENSIVE HIV/AIDS PRE

STATE ADMINISTRATIVE MATCHING GRANTS FOR FOOD STAMP PROGRAM

NATIONAL ORGANIZATIONS FOR CHRONIC DISEASE PREVENTION AND HEALTH PROMOTION

STRENGTHENING TB AND HIV/AIDS RESPONSE IN THE SOUTH WESTERN

FY 2011 FOSTER CARE

CLINICAL AND TRANSLATIONAL SCIENCE COLLABORATIVE OF CLEVELAND

2009 CCDFS

2008 OCSE

NSF CENTER FOR LAYERED POLYMERIC SYSTEMS

EXPANDING CAPACITY AND PARTNERSHIPS TO ADDRESS THE OVERDOSE EPIDEMIC

CENTER FOR AIDS RESEARCH(CFAR)

PPHF 2013: OSTLTS PARTNERSHIPS - CBA OF THE PUBLIC HEALTH SYSTEM

INTEGRATED HIV/AIDS PROGRAM -- IHAP-KINSHASA

ATTAINING AND SUSTAINING HIV EPIDEMIC CONTROL IN THE WEST AND WEST NILE REGIONS OF UGANDA THROUGH OPTIMIZATION OF HIGH IMPACT INTERVENTIONS TO ACHIEVE UNAIDS 95:95:95 TARGETS.

PARTERING WITH THE MINISTRY OF HEALTH OF VIETNAM

HIV/AIDS CLINICAL SERVICES PROGRAM IN RWANDA

HEALTH CENTER CLUSTER

HIV CARE, SUPPORT & TREATMENT: IMPLEMENTATION OF PROGRAM FOR THE CARE OF HIV/AIDS

THE PURPOSE OF THIS PROGRAM IS TO CONDUCT ACTIVITIES INVOLVING EFFECTIVE AND TESTED APPROACHES TO PROVIDING COMPREHENSIE AND INTEGRATED HIV/AIDS CARE

UTILIZING DATA AND DIVERSE PERSPECTIVES TO ENHANCE PUBLIC HEALTH AND CLINICAL OUTCOMES FOR PREGNANT AND POSTPARTUM PEOPLE, INFANTS, PEOPLE WITH BIRTH DEFECTS, INFANT DISORDERS AND RELATED CONDITIONS

ASTHMA INFLAMMATION RESEARCH (AIR)

SPECIAL SUPPLEMENTAL NUTRITION PROGRAM FOR WOMEN, INFANTS, AND CHILDREN

SPECIAL SUPPLEMENTAL NUTRITION PROGRAM FOR WOMEN, INFANTS, AND CHILDREN

SPECIAL SUPPLEMENTAL NUTRITION PROGRAM FOR WOMEN, INFANTS, AND CHILDREN

STRENGTHENING ZAMBIA DEFENSE FORCE HIV/AIDS PREVENTION PROGRAM

SPECIAL SUPPLEMENTAL NUTRITION PROGRAM FOR WOMEN INFANTS AND CHILDREN

IMPLEMENTATION OF PROGRAMS TO IMPROVE THE PREVENTION OF MOTHER TO CHILD TRANSMISS

RESEARCH RESOURCE FOR HUMAN ORGANS AND TISSUES

CASE GI SPORE

HEALTH CENTER CLUSTER

CLINICAL AND TRANSLATIONAL SCIENCE COLLABORATIVE OF NORTHERN OHIO, CATALYZING LINKAGES TO EQUITY IN HEALTH (CLE HEALTH) - PROJECT SUMMARY/ABSTRACT FOR THE PAST 15 YEARS, THE CLINICAL AND TRANSLATIONAL SCIENCE COLLABORATIVE (CTSC) AT CASE WESTERN RESERVE UNIVERSITY (CWRU) HAS LINKED CLINICAL AND TRANSLATIONAL RESEARCH EFFORTS AT FIVE INDEPENDENT INSTITUTIONS— CWRU, CLEVELAND CLINIC, METROHEALTH SYSTEM, UNIVERSITY HOSPITALS OF CLEVELAND, AND LOUIS STOKES CLEVELAND VETERANS AFFAIRS MEDICAL CENTER. TWO NEW PARTNERS (UNIVERSITY OF TOLEDO SCHOOL OF MEDICINE AND NORTHEAST OHIO MEDICAL UNIVERSITY) ARE NOW BEING ADDED TO EXTEND THE CTSC’S REACH ACROSS NORTHERN OHIO. THE CWRU CTSC HAS A STRONG TRACK RECORD OF ENHANCING THE QUANTITY AND QUALITY OF CLINICAL AND TRANSLATIONAL SCIENCE (CTS) AMONG OUR PARTNERS BY FACILITATING NOVEL RESEARCH PARADIGMS, TECHNOLOGIES, AND TRAINING. OUR CTSC HAS DEVELOPED A NEW GENERATION OF RESEARCHERS, ENHANCED COLLABORATIONS AMONG INVESTIGATORS, STREAMLINED DISCOVERY BY BUILDING PARTNERSHIPS AMONG INDUSTRY AND COMMUNITY AND ORGANIZATIONAL PARTNERS, AND FACILITATED MANY SUCCESSFUL ENTREPRENEURIAL STARTUPS. BUILDING ON THIS SOLID FOUNDATION, THE CWRU CTSC PROPOSES AN EXPANDED FOCUS ON HEALTH EQUITY, REFLECTED IN THE PROJECT THEME CATALYZING LINKAGES TO EQUITY IN HEALTH (CLE HEALTH). SOCIAL, ECONOMIC, AND ENVIRONMENTAL DISADVANTAGES ARE LINKED TO POOR HEALTH OUTCOMES AND LEAD TO DISPARITIES IN LIFE EXPECTANCY, INFANT MORTALITY, AND RATES OF CHRONIC CONDITIONS. MINORITY GROUPS ARE OFTEN UNDERREPRESENTED IN CLINICAL TRIALS AS WELL, MEANING THERE CAN BE INSUFFICIENT DATA FOR UNDERSTANDING THE EFFECTIVENESS OR SAFETY OF NEW DRUGS, PROCEDURES, OR HEALTH INTERVENTIONS FOR DIFFERENT POPULATIONS. THE OVERALL GOALS OF THIS PROJECT ARE TO 1) UNDERSTAND THE FUNDAMENTAL BARRIERS TO OPTIMAL RECRUITMENT OF UNDERREPRESENTED GROUPS IN CLINICAL TRIALS AND TEST AND SCALE INTERVENTIONS AIMED AT BREAKING DOWN THESE BARRIERS TO DIVERSIFY STUDY ENGAGEMENT, 2) FACILITATE AND EXPEDITE INNOVATION IN MULTICENTER CLINICAL AND TRANSLATIONAL RESEARCH BY FULLY INTEGRATING COMMUNITY AND STAKEHOLDER PARTNERS AND ENSURING THAT THIS RESEARCH REPRESENTS THE EXPERIENCES OF ALL AND RESULTS IN HEALTH IMPROVEMENTS FOR ALL, 3) DISSEMINATE AND IMPLEMENT NOVEL AND RESPONSIVE RESEARCH PROGRAMS ACROSS CLINICAL AND COMMUNITY SETTINGS TO ADVANCE ACCESS TO HEALTH INTERVENTIONS THAT AIM TO PROMOTE HEALTH EQUITY, AND 4) CREATE AND DISSEMINATE INCLUSIVE AND HIGH IMPACT EDUCATIONAL AND TRAINING PROGRAMS FOR TRANSLATIONAL RESEARCH PROFESSIONALS OF ALL DISCIPLINES AND LEVELS, BOTH IN CLINICAL AND COMMUNITY SETTINGS. THE CTSC HAS DESIGNED A STRATEGIC MANAGEMENT CORE AND SIX CTS RESEARCH AND TRAINING ELEMENTS TO ACCOMPLISH THESE GOALS: WORKFORCE DEVELOPMENT, COMMUNITY & STAKEHOLDER ENGAGEMENT, RESOURCES & SERVICES, CTS PILOT, HEALTH INFORMATICS, AND CTS RESEARCH PROGRAM. WE ARE COMMITTED TO INNOVATIVE AND COLLABORATIVE PRACTICE AND DISSEMINATION OF RESULTS SO THAT EVERYONE IN NORTHERN OHIO—AND BEYOND—CAN BENEFIT FROM ADVANCES IN CTS IN OUR PROGRAMS AND DISCOVERIES.

WEATHERIZATION ASSISTANCE FOR LOW-INCOME PERSONS - STATE OF KENTUCKY - NEW AWARD FOR PROGRAM YEAR 2007 WAP SOLICITATION DE-PS26-07NT43078 DOE ALLOC

THE DESERT RAIL INFRASTRUCTURE IMPROVEMENT PROJECT WILL COMPLETE FINAL DESIGN (FD) AND CONSTRUCTION OF 36 MILES OF RAIL FOR THE ARIZONA CALIFORNIA RAILROAD COMPANY. THE PROJECT CONSISTS OF REPLACING HIGH-DEFECT-RATE AND WORN RAIL, SURFACING, AND SPOT TIE REPLACEMENT, CROSSING REHABILITATION, AND TURNOUT REPLACEMENT. THE PROJECT WILL IMPROVE SYSTEM PERFORMANCE, COMPETITIVENESS, AND RELIABILITY SO THAT IT CAN SUPPORT THE EXISTING AND FUTURE TRAFFIC DEMANDS. ADDITIONALLY, THE PROJECT WILL REDUCE RISK OF DERAILMENTS, SERVICE FAILURES, REDUCE SERVICE FAILURES, AND INCREASE CAPACITY.

THE LOCAL ORGANIZATIONS NETWORK (LON) FOR ZAMBIA WILL MAXIMIZE THE POTENTIAL IMPACT OF USAID RESOURCES TO MAKE SUSTAINABLE IMPROVEMENTS IN TB SERVICES BY SHIFTING ACCOUNTABILITY AND OWNERSHIP TO LOCAL STAKEHOLDERS. THROUGH THE LON, THE RECIPIENT WILL SUPPORT THE NTP IN CROSS CUTTING AREAS INCLUDING TRAINING AND MENTORSHIP, PATIENT INFORMATION SYSTEMS (INCLUDING LAB INFORMATION), DOMESTIC RESOURCE MOBILIZATION, OPERATIONS RESEARCH AND COMMODITY MANAGEMENT.

SCIENCE, TECHNOLOGY, ENGINEERING, AND MATHEMATICS (STEM) NOTE: IF GRANTS OFFICER OF RECORD IS UNREACHABLE, THE ALTERNATE GRANTS OFFICER IS MS. MORG

MEDICAL SCIENTIST TRAINING PROGRAM

BREAKTHROUGH ELECTROLYTES FOR ENERGY STORAGE (BEES)

IFNS AND CYTOKINES: SIGNALING AND ACTION

2007 OCSE

ADDRESSING EMERGING INFECTIOUS DISEASES IN BANGLADESH

PROVISION OF HIV/AIDS TREATMENT SVC BY LOCAL INDIGENOUS ENTITIES (PROGRAM AREA 4)

OXIDATION IN INFLAMMATION AND CARDIOVASCULAR DISEASE

PULMONARY VASCULAR DISEASE PHENOMICS PROGRAM (PVDOMICS) DATA COORDINATING CENTER

VASCULAR CELL FUNCTION AND ATHEROSCLEROSIS

STRUCTURE AND FUNCTION OF BETA3 INTEGRINS ON BLOOD CELLS

THE PURPOSE OF THE USAID EMPOWERED YOUTH PROGRAM III IS TO IMPROVE THE RESILIENCE AND HEALTH OUTCOMES OF VULNERABLE HOUSEHOLDS IN THE FOLLOWING HIV-BURDEN PROVINCES OF ZAMBIA (I.E. LUSAKA, EASTERN AND WESTERN), WHILE STRENGTHENING THE GOVERNMENT OF THE REPUBLIC OF ZAMBIA (GRZ) SOCIAL PROTECTION PLATFORM SO THAT THE GRZ EVENTUALLY PROVIDES THE MAJORITY OF SERVICES TO VULNERABLE CHILDREN AND ADOLESCENTS (VCA).

STRENGTHEN MOH/VAAC?S CAPACITY TO SUSTAIN AND EXPAND QUALITY HIV PREVENTION, CARE AND TREATMENT SERVICES FOR PLHIV AND KEY POPULATIONS (KP)TO REACH EPIDEMIC CONTROL BY 2020 AND END AIDS BY 2030

ADVANCING PUBLIC HEALTH RESEARCH IN BANGLADESH

ADDRESSING EMERGING INFECTIONS DISEASE IN BANGLADESH

INTENSIVE OUTPATIENT CARE PROGRAM (IOCP)

BUILDING CAPACITY FOR SCALING UP HIV/AIDS SERVICES IN KIBAALE AND KIBOGA DISTRICT

STRENGTHENING PARTNERSHIPS FOR PREPAREDNESS AND RESPONSE IN UGANDA

ASSOCIATION OF STATE AND TERRITORIAL CHRONIC DISEASE PROGRAM DIRECTORS

THE PURPOSE OF THIS ANNOUNCEMENT IS TO SOLICIT APPLICANTS CAPABLE OF PROVIDING IN PERSON TRAINING, SUPPORT, ASSESSMENT, AND EVALUATION SERVICES SPONSORED BY THE DOD AND OTHER FEDERAL AGENCIES IN PARTNERSHIP WITH LOCAL DOD LABORATORIES, STEM EDUCATION ORGANIZATIONS, PROFESSIONAL SOCIETIES, AND LOCAL EDUCATION ACTIVITIES.

TRANSFORMING CLINICAL PRACTICES INITIATIVE - PTN

PARTNERSHIPS TO STRENGTHEN HEALTH SECURITY AND RESPOND TO HEALTH THREATS

TRANSITIONING AND INTEGRATING LABORATORY SERVICES FOR HIGH QUALITY HIV DIAGNOSIS, CARE, TREATMENT, AND MONITORING TO THE MINISTRY OF HEALTH (MOH) TO SUSTAIN ACHIEVEMENT OF THE 95-95-95 GOALS IN ZAMBIA - THE CENTRE FOR INFECTIOUS DISEASE RESEARCH IN ZAMBIA (CIDRZ), TOGETHER WITH THE ASSOCIATION OF PUBLIC HEALTH LABORATORIES (APHL), WITS HEALTH CONSORTIUM (WHC), CLINICAL AND LABORATORY STANDARDS INSTITUTE (CLSI) AND FIND DIAGNOSTICS HAVE ESTABLISHED A CONSORTIUM TO SUPPORT ‘TRANSITIONING AND INTEGRATING LABORATORY SERVICES FOR HIGH QUALITY HIV DIAGNOSIS, CARE, TREATMENT, AND MONITORING TO THE MINISTRY OF HEALTH (MOH) TO SUSTAIN ACHIEVEMENT OF THE 95-95-95 GOALS IN ZAMBIA UNDER PEPFAR’. EFFECTIVE AND EFFICIENT DISEASE DIAGNOSTICS ARE AN ESSENTIAL COMPONENT OF ANY RESILIENT HEALTH SYSTEM. STRONG LABORATORY (LAB) DIAGNOSTIC CAPACITY IS IMPORTANT FOR DISEASE SURVEILLANCE, DIAGNOSIS, PREVENTION, TREATMENT, HEALTH PROMOTION NOW MORE THAN EVER, GIVEN THE MYRIAD OF POTENTIAL GLOBAL HEALTH THREATS. LABS ARE A CRITICAL COMPONENT IN ACHIEVING THE UNAIDS 95-95-95 TARGETS TO HAVE AN AIDS-FREE GENERATION, RESPOND TO EMERGING PATHOGENS AND PROVIDE OPTIMAL CARE FOR HIV+ INDIVIDUALS. OVER THE PAST DECADE, TREMENDOUS EFFORTS HAVE BEEN MADE TO DEVELOP AND STRENGTHEN LAB SYSTEMS TO ADEQUATELY RESPOND TO THE SCALE UP OF THE ART PROGRAM IN PEPFAR COUNTRIES AND ADAPT THESE TO HEALTH CHALLENGES; HOWEVER, SEVERAL BARRIERS PERSIST IN CREATING SUSTAINABLE, ACCESSIBLE, AND EFFICIENT HIGH-QUALITY SYSTEMS THAT GOVERNMENTS CAN ADMINISTER WITH MINIMAL EXTERNAL SUPPORT. ZAMBIA CONTINUES TO MAKE PROGRESS TOWARDS ENDING THE AIDS EPIDEMIC BY 2030 BY ADOPTING THE 95-95-95 TARGETS. THE COUNTRY HAS ATTAINED THE SECOND (98%) AND THIRD (96.3%) TARGET AMONG PERSONS >=15 YEARS OF AGE. DESPITE THESE REMARKABLE ACCOMPLISHMENTS, CHALLENGES REMAIN IN ATTAINING THE FIRST TARGET AMONG ADULTS, FOR CHILDREN <15 YEARS AND KEY AND PRIORITY POPULATIONS ACROSS ALL THREE TARGETS. ADDRESSING THE REMAINING PROGRAMMATIC CHALLENGES IN DIAGNOSIS, TREATMENT, ADHERENCE, AND FULL GOVERNMENT IMPLEMENTATION OF THE HEALTH SYSTEM WILL ACCELERATE ZAMBIA’S ATTAINMENT OF THE UNAIDS AND PEPFAR GOALS. OUR CONSORTIUM HAS OVER 20 YEARS OF COMBINED INSTITUTIONAL EXPERIENCE IN ZAMBIA AND THE SUB-REGION TO EXPAND HIV PREVENTION, CARE AND TREATMENT SERVICES INCLUDING LAB SYSTEMS STRENGTHENING. MORE SPECIFICALLY, WE HAVE MENTORED LABS TO ACHIEVE INTERNATIONAL ISO15189 ACCREDITATION, PROVIDED TECHNICAL AND MATERIAL SUPPORT TO ESTABLISH AND IMPROVE INTEGRATED SAMPLE COURIER NETWORKS, DIGITAL SAMPLE REFERRAL AND RESULTS RETURN, WASTE MANAGEMENT, BACKUP POWER SYSTEMS AND ASSISTED GOVERNMENT TO FIND GAPS AND FIX THEM AT ALL LEVELS OF LAB OPERATIONS. OUR CONSORTIUM WILL IMPLEMENT PROVEN STRATEGIES THAT INCLUDE THE DEVELOPMENT AND SHARING OF POLICIES AND GUIDANCE, AND IMPLEMENTATION OF ACTIVITIES THAT: 1) MAINTAIN CONTINUITY WITH PRIOR LAB STRENGTHENING EFFORTS IN DIGITAL SAMPLE REFERRAL AND RESULTS RETURN, INTEGRATED SAMPLE COURIER SYSTEMS, QUALITY MANAGEMENT SYSTEMS, MEDICAL WASTE MANAGEMENT, POWER BACKUP AND OTHER GAPS IN THE LAB VALUE CHAIN; 2)PROVIDE TECHNICAL ASSISTANCE (TA) TO ACHIEVE FULL SYSTEM FUNCTIONALITY AT ALL LEVELS OF THE LAB NETWORK FROM FACILITY TO NATIONAL LEVEL; 3) CONDUCT CAPACITY ASSESSMENT OF PARTNER-SUPPORTED LAB SYSTEMS INCLUDING COSTING REQUIRED TO MAINTAIN LAB SERVICES, AND 4) TRANSITION LAB SERVICES TO FULL GOVERNMENT CONTROL THROUGH A STEPWISE TRANSITION APPROACH FOR MOH IMPLEMENTATION AND OVERSIGHT. OUR APPROACH IS ANCHORED IN PROVEN EXPERIENCE BUILDING AND STRENGTHENING PUBLIC -PRIVATE PARTNERSHIPS, PROMOTING COUNTRY OWNERSHIP/ LEADERSHIP, AND PROVIDING KNOWLEDGE AND MATERIAL SUPPORT TO GOVERNMENT TECHNICAL WORKING GROUPS TO DEVELOP POLICIES FOR INCREASED ACCESS TO HIGH QUALITY LAB TESTING. OUR CONSORTIUM HAS ALSO BEEN ABLE TO EMPOWER GOVERNMENT STAFF TO SUPPORT THE INTEGRATION OF LAB SERVICES AND SYSTEMS, TRAINING, AND LOGISTICS. OUR CONSORTIUM WILL WORK COLLABORATIVELY WITH THE ZAMBIAN GOVERNMENT THROUGH THE MOH AND OTHER STAKEHOLDERS TO ACHIEVE OUR VISION OF A RESILIENT AND SUSTAINABLE HIGH-QUALITY NATIONAL LABORATORY NETWORK FULLY MANAGED BY THE ZAMBIAN GOVERNMENT.

ELIZABETH GLASER PEDIATRIC AIDS FOUNDATION - TAIBITEN PROJECT - DEVELOP, IMPLEMENT, AND SUSTAIN HIGH-QUALITY COMPREHENSIVE FACILITY AND COMMUNITY-BASED HIV ACTIVITIES IN CAMEROON - ELIZABETH GLASER PEDIATRIC AIDS FOUNDATION - TAÏBITEN PROJECT - DEVELOP, IMPLEMENT, AND SUSTAIN HIGH-QUALITY COMPREHENSIVE FACILITY AND COMMUNITY-BASED HIV ACTIVITIES IN CAMEROON

THE PURPOSE OF THIS MODIFICATION IS TO PROVIDE INCREMENTAL FUNDING IN THE AMOUNT OF $999,352.00.

ACUTE HUMORAL REJECTION OF RENAL ALLOGRAFTS

THE NATIONAL HEALTHY BRAIN INITIATIVE: DEVELOP AND ADVANCE IMPLEMENTATION OF PUBLIC HEALTH STRATEGIES

PPHF 2013: OSTLTS PARTNERSHIPS - CBA OF THE PUBLIC HEALTH SYSTEM

2010 OCSE

2009 CSBGS

INNATE IMMUNITY END EXPERIMENTAL CROHN'S DISEASE

URBAN COUNTIES

ALCOHOL AND TISSUE INJURY FROM MECHANISMS TO TREATMENTS

PEPFAR SUPPORTED COUNTRIES

CWRU CENTER FOR EXCELLENCE ON THE IMPACT OF SUBSTANCE USE ON HIV - PROJECT SUMMARY - OVERVIEW THE NEWLY DEVELOPED CWRU (CASE WESTERN RESERVE UNIVERSITY) CENTER FOR EXCELLENCE ON THE IMPACT OF SUBSTANCE USE ON HIV WAS CONCEIVED IN AUGUST 2017 AND WAS INITIATED TO EFFECTIVELY PROMOTE EXCELLENCE IN BASIC, TRANSLATIONAL, AND CLINICAL RESEARCH CONCERNING THE INTERSECTION BETWEEN SUBSTANCE USE AND HIV. THE CENTER FOR EXCELLENCE INCLUDES 12 NIDA-FUNDED INVESTIGATORS WHO COLLECTIVELY HOLD 9 R01, 2 DP1, 3 R34, 2 R44, 1 U01, AND 2 K01 DRAWN FROM THE CWRU SCHOOL OF MEDICINE, UNIVERSITY HOSPITALS CLEVELAND MEDICAL CENTER, METROHEALTH MEDICAL CENTER, THE CLEVELAND CLINIC FOUNDATION, THE LOUIS STOKES CLEVELAND VETERANS ADMINISTRATION MEDICAL CENTER, THE CWRU MANDEL SCHOOL OF APPLIED SOCIAL SCIENCES, THE BEGUN CENTER FOR VIOLENCE PREVENTION RESEARCH AND EDUCATION, AND THE CUYAHOGA COUNTY, LORAIN COUNTY, AND CITY OF CLEVELAND DEPARTMENTS OF HEALTH. MAJOR RESEARCH STRENGTHS IN THE CENTER FOR EXCELLENCE INCLUDE IMPACT OF DRUG USE ON HIV IMMUNOPATHOGENESIS, HIV LATENCY AND CURE, NEUROAIDS, GASTROINTESTINAL DYSFUNCTION, SEXUAL RISK BEHAVIOR, AND HIV AND HCV CO-INFECTIONS. OUR STUDIES ARE ANCHORED BY ADVANCED COMPUTATIONAL, SYSTEMS BIOLOGY, BIOMIMETIC MODELS, AND INDUCED PLURIPOTENT STEM CELL (IPSC) TECHNOLOGIES THAT PROVIDE THE OPPORTUNITY TO PERFORM META-OMICS ANALYSES OF THE IMPACT OF OPIOID, METHAMPHETAMINE, CANNABIS, AND COCAINE MISUSE ON SEVERAL CLINICAL, VIROLOGICAL, IMMUNOLOGICAL, BEHAVIORAL, AND NEUROLOGICAL OUTCOMES OF HIV DISEASE. THE CENTER FOR EXCELLENCE HAS THE FOLLOWING SPECIFIC AIMS: - PROVIDE SCIENTIFIC LEADERSHIP TO POSITION THE CENTER AT THE FOREFRONT OF SUBSTANCE USE DISORDER RESEARCH AND FUNCTION AS A NATIONAL RESEARCH RESOURCE FOR THE STUDY OF DRUG USE IN PERSONS WITH HIV. - ESTABLISH AN ADMINISTRATIVE INFRASTRUCTURE THAT MAINTAINS FISCAL AND MANAGEMENT OVERSIGHT OF THE CORES. - APPLY ADVANCED COMPUTATIONAL BIOLOGY, PRIMARY CELLS, BIOMIMETIC MODELS, AND IPSC- DERIVED CELLS TO STUDY OF THE IMPACT OF SUBSTANCE USE ON HIV DISEASE. - SUPPORT TRANSLATIONAL, CLINICAL, AND BEHAVIORAL RESEARCH THROUGH ACCESS TO UNIQUE CLINICAL COHORTS OF PERSONS WITH SUBSTANCE USE DISORDER WITH HIV AND AT RISK FOR HIV. - ACCELERATE JUNIOR FACULTY DEVELOPMENT AND ENCOURAGE EXPERIENCED FACULTY TO ENTER THE SUBSTANCE USE RESEARCH ARENA TO SUPPORT THE NEXT GENERATION OF INVESTIGATORS. - PARTICIPATE IN COMMUNITY OUTREACH.

URBAN COUNTIES

CONTINUING ENHANCED NATIONAL SURVEILLANCE FOR PRION DISEASES IN THE UNITED STATES

HYALURONAN MATRICES IN VASCULAR PATHOLOGIES

ACCELERATING COMPREHENSIVE HIV/AIDS SERVICE DELIVERY THROUGH HEALTH SYSTEMS CAPACITY BUILDING AND TECHNICAL ASSISTANCE TO DISTRICT HEALTH TEAMS AND H

CLEVELAND ALZHEIMERS DISEASE RESEARCH CENTER - PROJECT SUMMARY THE CLEVELAND ALZHEIMER'S DISEASE RESEARCH CENTER (CADRC) IS A COLLABORATIVE EFFORT OF PHYSICIANS AND INVESTIGATORS FROM CASE WESTERN RESERVE UNIVERSITY (CWRU), CLEVELAND CLINIC FOUNDATION (CCF), METROHEALTH SYSTEM (MHS), UNIVERSITY HOSPITALS (UH), AND THE LOUIS STOKES CLEVELAND VA MEDICAL CENTER (LSCVAMC), TO FOSTER EXCELLENCE IN RESEARCH AND FACILITATE DISCOVERY AS AN ESTABLISHED NATIONAL INSTITUTE ON AGING (NIA) FUNDED ALZHEIMER'S DISEASE RESEARCH CENTER. THE CADRC REPRESENTS A RICH CLINICAL AND RESEARCH COMMUNITY AND AN ESTIMATED 220,000 OHIOANS WHO SUFFER FROM ALZHEIMER'S DISEASE (AD) OR AD-RELATED DEMENTIAS (ADRD). THE CADRC HAS 8 CORES AND A RESEARCH EDUCATION COMPONENT DESIGNED TO CREATE THE FOUNDATION THAT WILL ENHANCE THE RESEARCH EFFORTS OF THE NORTHEAST OHIO AD/ADRD RESEARCH COMMUNITY, AS WELL AS ADD UNIQUE VALUE TO THE NATIONAL ALZHEIMER'S DISEASE RESEARCH CENTERS (ADRC) PROGRAM AND OTHER NATIONAL AND INTERNATIONAL RESEARCH PROGRAMS. THE CADRC IS FOCUSED ON PARTICIPANTS THAT WILL HELP US UNDERSTAND THE PATHOBIOLOGY OF CLINICAL AND PATHOLOGICAL HETEROGENEITY OBSERVED IN DEMENTIA INCLUDING ATYPICAL AND AMNESTIC AD, DEMENTIA WITH LEWY BODIES, COGNITIVELY NORMAL INDIVIDUALS WITH DIFFERENT LEVELS OF GENETIC RISK FOR AD, AND DIVERSITY OF PARTICIPANT POPULATIONS (CLINICAL AND OUTREACH, RECRUITMENT, AND ENGAGEMENT CORES). TO SUPPORT THE CADRC GOALS, THE FOCUS WILL BE ON DEEP PHENOTYPING OF PARTICIPANTS WITH LONGITUDINAL AND SYSTEMATIC COGNITIVE, BEHAVIORAL AND MOTOR CHARACTERIZATION (CLINICAL CORE), GENETIC AND BIOFLUID BIOMARKER COLLECTION AND ANALYSIS (BIOMARKER CORE), IMAGING (NEUROIMAGING CORE), AND AUTOPSY AFTER DEATH (NEUROPATHOLOGY CORE). RESULTS WILL BE SHARED WITH THE RESEARCH COMMUNITY IN A TIMELY AND REGULAR MANNER TO ALLOW OTHER INVESTIGATORS TO BENEFIT FROM THE CADRC EFFORTS (DATA MANAGEMENT AND STATISTICS CORE). IN ADDITION, THE CADRC WILL TRAIN THE NEXT GENERATION OF INVESTIGATORS UTILIZING A RIGOROUS AND WELL-DESIGNED RESEARCH EDUCATION COMPONENT, SUPPORT TRANSLATION OF NEW LABORATORY FINDINGS THROUGH THE TRANSLATIONAL THERAPEUTICS CORE, AND SUPPORT HIGH RISK/HIGH GAIN PROJECTS THROUGH THE DEVELOPMENTAL PROGRAM AS A PART OF THE ADMINISTRATIVE CORE. THE ULTIMATE GOALS ARE TO ADVANCE THE PRECISION MEDICINE APPROACH TO DEMENTIA DIAGNOSIS AND TREATMENT, SUPPORT THE DEVELOPMENT OF EARLY STAGE INVESTIGATORS, ASSIST ALL STAGES OF INVESTIGATORS WITH TOOLS FOR PERFORMING HUMAN-BASED RESEARCH, AND BETTER ENGAGE UNDERREPRESENTED POPULATIONS IN AD/ADRD RESEARCH.

GH13-1368: TECHNICAL ASSISTANCE SERVICES

GH15-1548, LESOTHO: SUPPORTING HIV AND TUBERCULOSIS RESPONSE THROUGH DISTRICT-BASED COMPREHENSIVE PREVENTION, CARE AND TREATMENT PROGRAMS AND HEALTH

DISTRICT HEALTH SYSTEM STRENGTHENING AND QUALITY IMPROVEMENT FOR SERVICE DELIVERY

SUPPORT THE CENTER FOR DISEASE CONTROL AND PREVENTION OF THE PEOPLES REPUBLIC

CENTER FOR DEMENTIA RESPITE INNOVATION

TO INCREASE AVAILABILITY ,ACCESSIBILITY AND UTILIZATION OF QUALITY INTEGRATED TB/HIV AND MDR TB SERVICES

CLEVELAND OPEN SOURCE MODULAR IMPLANT INNOVATORS COMMUNITY (COSMIIC) - THE OVERALL GOAL OF THE CLEVELAND OPEN SOURCE MODULAR IMPLANT INNOVATORS COMMUNITY (COSMIIC) IS TO ESTABLISH AN OPEN SOURCE, MODULAR NETWORK OF ACTIVE IMPLANTABLE DEVICES FOR USE IN EARLY FEASIBILITY HUMAN RESEARCH AND TO PROVIDE ONGOING SUPPORT FOR THIS TECHNOLOGY THROUGH A VIBRANT, SUSTAINABLE COMMUNITY OF ACTIVE USERS. OUR TEAM IS POISED TO SUCCESSFULLY ACHIEVE ALL OF THE GOALS OF THE HORNET PROGRAM BECAUSE OUR PROPOSED CONCEPT IS BASED ON OUR ESTABLISHED PLATFORM ECOSYSTEM, THE NETWORKED NEUROPROSTHESIS (NNP). THIS PROVIDES A SOLID TECHNOLOGICAL PLATFORM WITH KNOWN REGULATORY STATUS FOR OUR COSMIIC HORNET PROJECT. CRITICALLY, ALL TECHNOLOGY DESCRIBED IN THIS PROPOSAL WAS INVENTED BY THE INVESTIGATIVE TEAM AND THEREFORE WE ARE ABLE TO FULLY EMBRACE THE OPEN SOURCE IDEOLOGY FOR THE END-TO-END TECHNOLOGY. THE PROPOSED COSMIIC HORNET SYSTEM, WHICH WILL BE ESTABLISHED ON THE PLATFORM NNP SYSTEM, IS A SYSTEM OF INTEROPERABLE AND INTEGRATED MODULES THAT CAN SIMULTANEOUSLY ELECTRICALLY ACTIVATE, BLOCK, AND SENSE THROUGHOUT THE BODY. THE SYSTEM CAN RECORD AND PROCESS ELECTRONEUROGRAM (ENG), ELECTROMYOGRAM (EMG), INTRACORTICAL SIGNALS, ELECTROCARDIOGRAM (EKG), KINEMATIC VARIABLES, PHOTOPLETHYSMOGRAM (PPG), AND TEMPERATURE. EACH MODULE CAN DIRECTLY COMMUNICATE WITH ALL OTHER MODULES THROUGH AN ESTABLISHED NETWORK COMMUNICATION PROTOCOL. THE SYSTEM CAN PROCESS SIGNALS TO IMPLEMENT COMPLEX CLOSED-LOOP CONTROL WITHOUT REQUIRING NON-IMPLANTED HARDWARE. IMPORTANTLY, THE EXISTING NNP PLATFORM COMPONENTS (POWER MODULE, STIMULATOR MODULE, BIOPOTENTIAL RECORDING MODULE, NETWORK CABLE, ELECTRODES) ALREADY HAVE IDE APPROVAL FROM THE FDA AND HAVE BEEN SUCCESSFULLY IMPLANTED AND IMPLEMENTED IN HUMAN RESEARCH PARTICIPANTS. THUS, THE COSMIIC HORNET SYSTEM HAS THE NECESSARY FEATURES TO PROVIDE THE MODULAR PLATFORM ECOSYSTEM FOR USE BY THE BIOELECTRONIC COMMUNITY FOR THE FORESEEABLE FUTURE. AIM #1. DISSEMINATION. WE WILL ESTABLISH THE COSMIIC COMMUNITY WITH FULL OPEN-SOURCE ACCESS TO AN ESTABLISHED MODULAR IMPLANTABLE DEVICE FOR USE IN THE PERIPHERAL AND CENTRAL NERVOUS SYSTEM. ACCESS WILL BE GIVEN FOR ALL CIRCUIT DESIGNS AND LAYOUTS; MECHANICAL DRAWINGS FOR ALL ENCLOSURES AND CONNECTORS AND CABLING; THE ANNOTATED CODE FOR ALL OPERATING SOFTWARE, FIRMWARE, AND BOOTLOADER; WRITTEN INSTRUCTIONS AND VIDEOS OF FABRICATION TECHNIQUES; AND ALL REGULATORY DOCUMENTS AND TEST DATA, INCLUDING OUR APPROVED IDE DOCUMENT. AIM #2. SUSTAINABILITY. WE WILL DEVELOP A SUSTAINABLE OPEN SOURCE MODEL THROUGH THE DEVELOPMENT OF TECHNOLOGY THAT ATTRACTS A BROAD INVESTIGATIVE TEAM TO ESTABLISH A CRITICAL MASS OF COSMIIC USERS. WE WILL PROVIDE ONGOING SUPPORT OF THE TECHNOLOGY AND PARTNER WITH COMMERCIAL PARTNERS TO CREATE A SUSTAINABLE BUSINESS PLAN SO THAT THE COSMIIC COMMUNITY REMAINS INDEPENDENTLY VIBRANT AND ACTIVE AFTER THREE YEARS.

THE ALZHEIMER DISEASE SEQUENCE ANALYSIS COLLABORATIVE

CONTINUING AN ENHANCED AND MULTIFACETED NATIONAL SURVEILLANCE PROGRAM FOR HUMAN PRION DISEASES

USAID'S RESEARCH FOR DECISION MAKERS ACTIVITY

NATIONAL ORGANIZATION FOR CHRONIC DISEASE PREVENTION AND HEALTH PROMOTION

THE CLEVELAND CLINIC INNOVATION ACCELERATOR

INCREASING ACCESS TO COMPREHENSIVE HIV/AIDS PREVENTION CARE

ELIZABETH GLASER PEDIATRIC AIDS FOUNDATION DRC DHAPP-FARDC ELIKYA PROJECT

THE PURPOSE OF THIS COOPERATIVE AGREEMENT IS TO SUPPORT THE GOVERNMENT OF THE KINGDOM OFSWAZILAND (GKOS) IN THE IMPLEMENTATION OF A PREVENTION OF M

PATHOBIOLOGY OF ASTHMA

GENETIC DETERMINANTS OF BARRETT'S ESOPHAGUS AND ESOPHAGEAL ADENOCARCINOMA

SPORE IN OVARIAN CANCER

LIBBY, MONTANA'S PUBLIC HEALTH EMERGENCY: ASBESTOS HEALTH SCREENING

ARP SUPPORT FOR SURVIVORS OF DOMESTIC VIOLENCE AND SEXUAL ASSAULT FROM CULTURALLY SPECIFIC POPULATIONS GRANT PROGRAM

THE CLEVELAND DIGESTIVE DISEASES RESEARCH CORE CENTER (DDRCC)

IMPROVE EXISTING AIRPORT

STRENGTHENING COMMUNITY-BASED HIV/AIDS PREVENTION AND CARE SERVICES IN THE UNDERS

INCREMENTAL FUNDING IN THE AMOUNT OF $300,000

PHARMACOLOGICAL TREATMENT OF RETINAL DISEASES

COHORT STUDY OF CHRONIC RENAL INSUFFICIENCY

MERGENCY FINANCIAL GRANTS UNDER THE CORONAVIRUS AID, RELIEF AND ECONOMIC SECURITY (CARES) ACT.

TECHNICAL ASSISTANCE FOR RESPONSE TO PUBLIC HEALTH OR HEALTHCARE CRISES - 2018

IBUDILAST PHASE II TRIAL IN PROGRESSIVE MS

HIGHER EDUCATION EMERGENCY RELIEF FUND-INSTITUTIONAL PORTION CARES ACT

THE PURPOSE OF THIS COOPERATIVE AGREEMENT IS TO PROVIDE HIV PREVENTION AND TREATMENT SERVICES, AND BUILD CAPACITY OF ESWATINI'S INSTITUTIONS ACHIEVE EPIDEMIC CONTROL.

CASE AIDS CLINICAL TRIALS UNIT

TARGETING OBESITY AND BLOOD PRESSURE IN URBAN YOUTH

STRENGTHENING THE BASICS: PROVINCIAL HEALTH SYSTEMS STRENGTHENING TO SUPPORT HIGH

STATE ADMINISTRATIVE MATCHING GRANTS FOR SUPPLEMENTAL NUTRITION ASSISTANCE PROGRAM

RYAN WHITE PART C OUTPATIENT EIS PROGRAM

OPTIMIZING COVID-19 INFECTION PREVENTION & CONTROL IN CLINICAL PRACTICE - 1. REAL TIME LEARNING NETWORK AND CLINICIAN ON-CALL PROJECTIDSA HAS PROPOSED A SET OF 11 PROGRAMS AND ASSOCIATED ACTIVITIES FOR EACH THAT ARE DESIGNED TO ADVANCE THE STRATEGIES OUTLINED WITHIN THIS COOPERATIVE AGREEMENT. THESE PROGRAMS ARE DESIGNED TO WORK DYNAMICALLY TO HELP CDC MEET THE SHORT-, INTERMEDIATE- AND LONG-TERM OUTCOMES DESIRED FROM THIS FUNDING OPPORTUNITY.2. ANTIMICROBIAL STEWARDSHIP PROJECTTHE GOAL OF THIS PROJECT WILL BE TO DEVELOP AN IMPLEMENTATION BUNDLE AND CHECKLIST THAT STEWARDSHIP PROGRAMS COULD USE TO IMPROVE PRESCRIBING FOR RESPIRATORY ILLNESSES AT THEIR HOSPITALS DURING AND AFTER THE COVID-19 PANDEMIC.

PROVIDING A COMPREHESIVE CONTINUM OF HIV/AIDS CARE AND TREATEMENT SERVICES IN THE

GUT MICROBIOTA AND CARDIOMETABOLIC DISEASES

VANCOUVER DRUG USERS STUDY: EVALUATING THE NATURAL HISTORY OF INJECTION DRUG USE

CELL ADHESION AND SIGNALING IN BLOOD AND VASCULAR CELLS - PROJECT SUMMARY THIS APPLICATION HAS AS ITS THEME THE INTEGRINS, THEIR REGULATION AND THEIR CONTRIBUTION TO THE FUNCTIONAL RESPONSES OF BLOOD AND VASCULAR CELLS. THE INTEGRINS OF FOCUS ARE AMSS2 (MAC-1), AIIBSS3, AVSS3, AND A5SS1 BUT FINDINGS SHOULD APPLY TO BROADLY INTEGRINS. THE CELLS OF EMPHASIS ARE VASCULAR CELLS- ENDOTHELIAL CELLS, SMOOTH MUSCLE CELLS AND PERICYTES- AND BLOOD CELLS- LEUKOCYTES AND PLATELETS. ON THE BLOOD CELLS, THE CONJUGATION OF MAC-1 ON LEUKOCYTES AND GPIB ON PLATELETS WILL BE CONSIDERED. MAJOR EMPHASIS WILL BE PLACED ON THE MOLECULES THAT REGULATE INTEGRIN FUNCTION- KINDLINS, TALIN AND PAXILLIN- TO DETERMINE HOW THEY COLLABORATE TO REGULATE INTEGRIN ACTIVATION. THE FUNCTION OF THESE CYTOSKELETAL PROTEINS INDEPENDENT OF INTEGRIN ACTIVATING ACTIVITY WILL ALSO BE DISSECTED. THE PROGRAM CONSISTS OF THREE PROJECTS, EACH DIRECTED BY AN ACCOMPLISHED FACULTY MEMBER AT THEIR HOME INSTITUTIONS, CLEVELAND CLINIC, UNIVERSITY HOSPITALS OF CLEVELAND AND CASE WESTERN RESERVE UNIVERSITY WHICH ARE ALL CLOSELY LOCATED AND GOVERNED BY INTERINSTITUTIONAL AGREEMENTS. DR. EDWARD F. PLOW, PH.D. WILL SERVE AS PROGRAM DIRECTOR AND LEAD PROJECT 1. THIS PROJECT DEALS WITH THE MECHANISMS BY WHICH KINDLIN-2 REGULATES BOTH INTEGRIN-DEPENDENT AND INDEPENDENT RESPONSES OF BLOOD VESSEL CELLS. MOLECULAR, CELLULAR AND UNIQUE MOUSE MODELS ARE ALL BROUGHT TO BEAR TO DETERMINE HOW KINDLIN-2 SERVES AS A MASTER REGULATOR OF VASCULAR CELL RESPONSES. IN PROJECT 2, DR. JUN QIN WILL USE HIGH RESOLUTION STRUCTURAL APPROACHES IN COMBINATION WITH MUTAGENESIS AND CELLULAR STUDIES TO DETERMINE HOW TALIN REGULATE INTEGRIN ACTIVATION AND COOPERATES WITH KINDLINS AND PAXILLIN TO GAIN SUCH NOVEL INSIGHTS. HE WILL DETERMINE HOW TALIN INTERACTS WITH ACTIN TO CONTROL ORGANIZATION OF THE CYTOSKELETON. DR. DANIEL SIMON, M.D. WILL LEAD PROJECT 3 AND WILL CONSIDER HOW ENGAGEMENT OF INTEGRIN MAC-1 ON LEUKOCYTES AND GPIB ON PLATELETS REGULATES THE PARTICIPATION OF THESE CELLS IN INFLAMMATION AND THROMBOSIS. HIS STUDIES RANGE FROM BASIC STRUCTURAL APPROACHES TO TRANSLATIONAL STUDIES IN MICE AND TO HUMANS TO PROVIDE INSIGHTS INTO THEIR THROMBOTIC AND INFLAMMATORY CONTRIBUTIONS TO SYSTEMIC LUPUS ERYTHEMATOSUS. THE PROGRAM IS SUPPORTED BY TWO SCIENTIFIC CORES, PROTEIN EXPRESSION AND PURIFICATION (CORE B), AND ANIMAL MODELS AND TISSUE ANALYSIS (CORE C) AS WELL AS BY AN ADMINISTRATIVE CORE (AC1). A COMMON OBJECTIVE OF THE PROGRAM IS TO CONTINUE AND CREATE NEW COLLABORATIONS AMONG THE PROJECTS AND THEIR LEADERS TO RESOLVE THE STRUCTURAL AND BIOLOGICAL MECHANISMS THAT REGULATE THE FUNCTIONS OF INTEGRINS IN BLOOD AND VASCULAR CELLS. THE INFORMATION DERIVED FROM THESE STUDIES WILL PROVIDE INSIGHTS INTO BIOLOGICALLY IMPORTANT RESPONSES REGULATED BY INTEGRINS AND THEIR ACTIVATION THAT ARE RELEVANT TO THROMBOSIS AND CARDIOVASCULAR DISEASES.

HDL STRUCTURE AND ITS FUNCTION IN ATHEROSCLEROSIS

P30 - CORE GRANT FOR VISION RESEARCH

CDC-RFA-GH19-1950: EGPAF DELTA 2

CWRU CENTER FOR MULTIMODAL EVALUATION OF ENGINEERED CARTILAGE

DEVELOPMENT OF NEW DIAGNOSTIC METHODS/SURVEILLANCE PROGRAM

FRMI OF THE PERSON IDENTITY NETWORK: AGING AND APOE

LATIN AMERICAN CENTER FOR MALARIA RESEARCH AND CONTROL

PREVENTION OF SECONDARY TRANSMISSION AMONG MOST-AT-RISK POPULATIONS

GRANT AWARD TO CASE WESTERN RESERVE UNIVERSITY (CWRU) CONTRIBUTES TO NNSA’S STOCKPILE STEWARDSHIP MISSION BY ESTABLISHING A UNIQUE PUBLIC-PRIVATE PARTNERSHIP MERGING MATERIALS SCIENCE WITH NOVEL COMPUTER SCIENCE AND DATA SCIENCE TO ADVANCE THE UNDERSTANDING OF FUNDAMENTAL MECHANISMS OF MATERIALS DEGRADATION AND FAILURE IN OUR NUCLEAR STOCKPILE MATERIALS AND COMPONENTS, THROUGH COMBINED RESEARCH AND EDUCATIONAL MULTI-DISCIPLINARY VISION. PROJECT TITLE: CENTER TO MATERIALS DATA SCIENCE FOR STOCKPILE STEWARDSHIP (MDS3) COE