Lee Inc

PURPOSE: COMMUNITY DEVELOPMENT BLOCK GRANT DISASTER RECOVERY (CDBG-DR) AND COMMUNITY DEVELOPMENT BLOCK GRANT MITIGATION (CDBG-MIT) GRANT FUNDS ARE APPROPRIATED BY CONGRESS AND ALLOCATED BY THE DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT (HUD) AS AUTHORIZED UNDER TITLE I OF THE HOUSING AND COMMUNITY DEVELOPMENT ACT OF 1974, AS AMENDED. THE MAIN PURPOSE OF CDBG-DR FUNDS IS TO REBUILD DISASTER-IMPACTED AREAS AND PROVIDE CRUCIAL SEED MONEY TO START THE LONG-TERM RECOVERY PROCESS. THESE FLEXIBLE GRANTS HELP CITIES, COUNTIES, INDIAN TRIBES, AND STATES RECOVER FROM PRESIDENTIALLY DECLARED DISASTERS, ESPECIALLY IN LOW-INCOME AREAS, SUBJECT TO AVAILABILITY OF SUPPLEMENTAL APPROPRIATIONS. SINCE CDBG-DR ASSISTANCE MAY FUND A BROAD RANGE OF RECOVERY ACTIVITIES, HUD CAN HELP COMMUNITIES AND NEIGHBORHOODS THAT OTHERWISE MIGHT NOT RECOVER DUE TO LIMITED RESOURCES.; ACTIVITIES TO BE PERFORMED: STATE AND LOCAL GOVERNMENTS RECEIVE CDBG-DR AND CDBG-MIT FUNDS FROM HUD TO ASSIST COMMUNITIES RECOVERING FROM A PRESIDENTIALLY DECLARED DISASTER. HUD ALLOCATES FUNDS BASED ON THE UNMET RECOVERY NEEDS OF EACH COMMUNITY. HUD ISSUES AN ALLOCATION ANNOUNCEMENT NOTICE IN THE FEDERAL REGISTER WHICH WILL INCLUDE THE LIST OF GRANTEES, ALLOCATIONS, AND ANY WAIVERS AND ALTERNATIVE REQUIREMENTS. GRANTEES MAY USE THE FUNDS FOR DISASTER RELATED LONG-TERM RECOVERY, RESTORATION OF INFRASTRUCTURE, HOUSING, ECONOMIC REVITALIZATION, AND MITIGATION ACTIVITIES. ALL CDBG-DR AND CDBG-MIT ACTIVITIES MUST CLEARLY ADDRESS A DIRECT OR INDIRECT IMPACT OF THE DISASTER IN A PRESIDENTIALLY DECLARED AREA FOR THE COVERED DISASTER. EACH GRANTEE MUST DEVELOP AN ACTION PLAN THAT OUTLINES HOW THE GRANTEE PLANS TO ALLOCATE FUNDING TO A COMBINATION OF RECOVERY PROGRAMS. EACH GRANTEE MUST MAKE THE DRAFT ACTION PLAN AVAILABLE FOR PUBLIC COMMENT AND FEEDBACK PRIOR TO SUBMITTING THE PLAN TO HUD FOR REVIEW. ONCE APPROVED, THE ACTION PLAN SERVES AS THE BLUEPRINT FOR THE GRANTEE’S CDBG-DR PROGRAM. THE ACTION PLAN PROCESS IS OUTLINED IN THE APPLICABLE ALLOCATION ANNOUNCEMENT NOTICE.; EXPECTED OUTCOMES: CDBG-DR FUNDS ARE EXPECTED TO RESULT IN LONG-TERM DISASTER RECOVERY FOR COMMUNITIES IMPACTED BY PRESIDENTIALLY DECLARED DISASTERS.; INTENDED BENEFICIARIES: CDBG-DR FUNDS ARE INTENDED PRIMARILY FOR LOW- AND MODERATE-INCOME HOUSEHOLDS PER STATUTORY REQUIREMENTS. CDBG-DR IS THE ONLY FEDERAL DISASTER RESOURCE THAT PRIORITIZES LOW- AND MODERATE-INCOME HOUSEHOLDS. LOW- AND MODERATE-INCOME MEANS A FAMILY OR HOUSEHOLD WITH AN ANNUAL INCOME LESS THAN THE SECTION 8 LOW INCOME LIMIT, WHICH IS GENERALLY 80 PERCENT OF THE AREA MEDIAN INCOME. MOST ALLOCATIONS OF CDBG-DR AND CDBG-MIT FUNDS REQUIRE GRANTEES USE 70 PERCENT OF THE GRANT FUNDS TO BENEFIT LOW- AND MODERATE-INCOME PERSONS, HOWEVER GRANTEES MUST REVIEW THE APPLICABLE FEDERAL REGISTER NOTICE GOVERNING THE FUNDS TO CONFIRM THE REQUIREMENTS OF EACH GRANT. OVERALL, CDBG-DR FUNDS SHOULD BE USED TO ASSIST INDIVIDUALS, COMMUNITIES, AND/OR BUSINESSES SITUATED IN THE MOST IMPACTED AND DISTRESSED AREAS AFFECTED BY A PRESIDENTIALLY DECLARED DISASTER.; SUBRECIPIENT ACTIVITIES: THE SUBRECIPIENT ACTIVITIES ARE UNKNOWN AT THE TIME OF AWARD.

PURPOSE: COMMUNITY DEVELOPMENT BLOCK GRANT DISASTER RECOVERY (CDBG-DR) AND COMMUNITY DEVELOPMENT BLOCK GRANT MITIGATION (CDBG-MIT) GRANT FUNDS ARE APPROPRIATED BY CONGRESS AND ALLOCATED BY THE DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT (HUD) AS AUTHORIZED UNDER TITLE I OF THE HOUSING AND COMMUNITY DEVELOPMENT ACT OF 1974, AS AMENDED. THE MAIN PURPOSE OF CDBG-DR FUNDS IS TO REBUILD DISASTER-IMPACTED AREAS AND PROVIDE CRUCIAL SEED MONEY TO START THE LONG-TERM RECOVERY PROCESS. THESE FLEXIBLE GRANTS HELP CITIES, COUNTIES, INDIAN TRIBES, AND STATES RECOVER FROM PRESIDENTIALLY DECLARED DISASTERS, ESPECIALLY IN LOW-INCOME AREAS, SUBJECT TO AVAILABILITY OF SUPPLEMENTAL APPROPRIATIONS. SINCE CDBG-DR ASSISTANCE MAY FUND A BROAD RANGE OF RECOVERY ACTIVITIES, HUD CAN HELP COMMUNITIES AND NEIGHBORHOODS THAT OTHERWISE MIGHT NOT RECOVER DUE TO LIMITED RESOURCES.; ACTIVITIES TO BE PERFORMED: STATE AND LOCAL GOVERNMENTS RECEIVE CDBG-DR AND CDBG-MIT FUNDS FROM HUD TO ASSIST COMMUNITIES RECOVERING FROM A PRESIDENTIALLY DECLARED DISASTER. HUD ALLOCATES FUNDS BASED ON THE UNMET RECOVERY NEEDS OF EACH COMMUNITY. HUD ISSUES AN ALLOCATION ANNOUNCEMENT NOTICE IN THE FEDERAL REGISTER WHICH WILL INCLUDE THE LIST OF GRANTEES, ALLOCATIONS, AND ANY WAIVERS AND ALTERNATIVE REQUIREMENTS. GRANTEES MAY USE THE FUNDS FOR DISASTER RELATED LONG-TERM RECOVERY, RESTORATION OF INFRASTRUCTURE, HOUSING, ECONOMIC REVITALIZATION, AND MITIGATION ACTIVITIES. ALL CDBG-DR AND CDBG-MIT ACTIVITIES MUST CLEARLY ADDRESS A DIRECT OR INDIRECT IMPACT OF THE DISASTER IN A PRESIDENTIALLY DECLARED AREA FOR THE COVERED DISASTER. EACH GRANTEE MUST DEVELOP AN ACTION PLAN THAT OUTLINES HOW THE GRANTEE PLANS TO ALLOCATE FUNDING TO A COMBINATION OF RECOVERY PROGRAMS. EACH GRANTEE MUST MAKE THE DRAFT ACTION PLAN AVAILABLE FOR PUBLIC COMMENT AND FEEDBACK PRIOR TO SUBMITTING THE PLAN TO HUD FOR REVIEW. ONCE APPROVED, THE ACTION PLAN SERVES AS THE BLUEPRINT FOR THE GRANTEE’S CDBG-DR PROGRAM. THE ACTION PLAN PROCESS IS OUTLINED IN THE APPLICABLE ALLOCATION ANNOUNCEMENT NOTICE.; EXPECTED OUTCOMES: CDBG-DR FUNDS ARE EXPECTED TO RESULT IN LONG-TERM DISASTER RECOVERY FOR COMMUNITIES IMPACTED BY PRESIDENTIALLY DECLARED DISASTERS.; INTENDED BENEFICIARIES: CDBG-DR FUNDS ARE INTENDED PRIMARILY FOR LOW- AND MODERATE-INCOME HOUSEHOLDS PER STATUTORY REQUIREMENTS. CDBG-DR IS THE ONLY FEDERAL DISASTER RESOURCE THAT PRIORITIZES LOW- AND MODERATE-INCOME HOUSEHOLDS. LOW- AND MODERATE-INCOME MEANS A FAMILY OR HOUSEHOLD WITH AN ANNUAL INCOME LESS THAN THE SECTION 8 LOW INCOME LIMIT, WHICH IS GENERALLY 80 PERCENT OF THE AREA MEDIAN INCOME. MOST ALLOCATIONS OF CDBG-DR AND CDBG-MIT FUNDS REQUIRE GRANTEES USE 70 PERCENT OF THE GRANT FUNDS TO BENEFIT LOW- AND MODERATE-INCOME PERSONS, HOWEVER GRANTEES MUST REVIEW THE APPLICABLE FEDERAL REGISTER NOTICE GOVERNING THE FUNDS TO CONFIRM THE REQUIREMENTS OF EACH GRANT. OVERALL, CDBG-DR FUNDS SHOULD BE USED TO ASSIST INDIVIDUALS, COMMUNITIES, AND/OR BUSINESSES SITUATED IN THE MOST IMPACTED AND DISTRESSED AREAS AFFECTED BY A PRESIDENTIALLY DECLARED DISASTER.; SUBRECIPIENT ACTIVITIES: THE SUBRECIPIENT ACTIVITIES ARE UNKNOWN AT THE TIME OF AWARD.

INDIAN HSG BLOCK GR

MOFFITT CANCER CENTER SUPPORT GRANT

IMPACT AID PROGRAM, TITLE VII, SECTION 7003

NATIONAL FUNCTIONAL GENOMICS CENTER

IMPACT AID PROGRAM, TITLE VII, SECTION 7003

IMPACT AID PROGRAM, TITLE VII, SECTION 7003

IMPACT AID PROGRAM, TITLE VII, SECTION 7003

IMPACT AID PROGRAM, TITLE VII, SECTION 7003

UNKNOWN TITLE

IMPACT AID PROGRAM, TITLE VIII, SECTION 8003

UNKNOWN TITLE

IMPACT AID PROGRAM, TITLE VII, SECTION 7003

IMPACT AID PROGRAM, TITLE VIII, SECTION 8003

IMPACT AID PROGRAM TITLE VIII SECTION 8003

IMPACT AID PROGRAM, TITLE VIII, SECTION 8003

IMPACT AID PROGRAM, TITLE VIII, SECTION 8003

IMPACT AID PROGRAM, TITLE VII, SECTION 7003

IMPACT AID PROGRAM, TITLE VIII, SECTION 8003

IMPACT AID PROGRAM TITLE VIII SECTION 8003

IMPACT AID PROGRAM TITLE VIII SECTION 8003

IMPACT AID PROGRAM TITLE VIII SECTION 8003 AND SECTION 8007(A)

HEAD START BASIC GRANT SERVING 720 LOW-INCOME AND DISABLED CHILDREN IN STANDARD HEAD START MODEL.

HEAD START AND EARLY HEAD START

PA-22 FYPD & PA-20 T&TA/CDA

HEAD START AND EARLY HEAD START

IMPACT AID PROGRAM, TITLE VIII, SECTION 8003

IMPROVE EXISTING AIRPORT

PA-22, PA-20

PURPOSE: AMERICAN RESCUE PLAN ACT AWARDED AS ECONOMIC ASSISTANCE TO ELIGIBLE U.S. AIRPORTS AND ELIGIBLE CONCESSIONS AT THOSE AIRPORTS TO PREVENT, PREPARE FOR, AND RESPOND TO THE COVID-19 PANDEMIC. ACTIVITIES TO BE PERFORMED/EXPECTED OUTCOMES: THIS GRANT PROVIDES ECONOMIC RELIEF FUNDS FOR COSTS RELATED TO OPERATIONS, PERSONNEL, CLEANING, SANITIZATION, JANITORIAL SERVICES, DEBT SERVICE PAYMENTS, AND COMBATING THE SPREAD OF PATHOGENS AT THE AIRPORT. INTENDED BENEFICIARY: THIS GRANT WILL PROVIDE FEDERAL FUNDING FOR AIRPORTS ASSOCIATED WITH FORT MYERS, FLORIDA.

HEAD START SUPPLEMENTAL REQUEST COLA

HEALTH CENTER CLUSTER

TEACHER INCENTIVE FUND

DESIGN AND INSTALLATION OF MEASURES TO RESTORE TIDAL HYDROLOGY, HABITATFOR AQUATIC ORGANISMS,AND SALT MARSH VEGETATION TO APPROXIMATELY 890ACRES OF SALT MARSH IN THE HERRING RIVER WATERSHED.

PURPOSE: EXPAND TERMINAL; CONSTRUCT TAXIWAY; EXPAND APRON; EXPAND/EXTEND TERMINAL ACCESS ROAD. ACTIVITIES TO BE PERFORMED/EXPECTED OUTCOMES: THIS PROJECT CONSTRUCTS A NEW 2,500 FOOT TAXIWAY E TO ACCOMMODATE MORE PASSENGERS. THIS PROJECT EXPANDS AN EXISTING CONCOURSE E APRON AN ADDITIONAL 80,000 SQUARE YARDS TO ACCOMMODATE MORE PASSENGERS. THIS PROJECT EXPANDS AN EXISTING TERMINAL ACCESS ROAD BY ADDING AN OFF RAMP AND THREE TRAFFIC LANES TO ACCOMMODATE MORE VEHICULAR TRAFFIC EXCLUSIVELY SERVING THE AIRPORT. THIS PROJECT EXPANDS THE EXISTING TERMINAL E BY 297,000 SQUARE FEET. THIS GRANT FUNDS THE DESIGN OF THE INSTALLATION OF NEW CHILLERS, NEW PEDESTRIAN BRIDGES, AND GATE MODIFICATIONS. THE EXPANSION WILL ACCOMMODATE MORE PASSENGERS. THIS GRANT FUNDS PHASE 1, WHICH CONSIST OF DESIGN. THIS GRANT FUNDS PHASE 1, WHICH CONSISTS OF DESIGN. INTENDED BENEFICIARY: THIS GRANT WILL PROVIDE FEDERAL FUNDING FOR AIRPORTS ASSOCIATED WITH FORT MYERS, FLORIDA.

AIAN HEAD START AND EARLY HEAD START

HEALTH CENTER CLUSTER

PONCE SCHOOL OF MEDICINE-MOFFITT CANCER CENTER PARTNERSHIP (2/2)

DESCRIPTION:THIS AGREEMENT PROVIDES FUNDING UNDER THE INFLATION REDUCTION ACT (IRA) TO LEECH LAKE BAND OF OJIBWE. SPECIFICALLY, THE PROJECT WILL BE CREATING A TRIBAL RESILIENCE HUB, THE CORNERSTONE OF THEIR CULTURAL RESILIENCE CAMPUS. THE ACTIVITIES INCLUDE TRIBAL STAFF TO BE HIRED TO INTERACT WITH THE COMMUNITY AND PROTECTING THE AIR, WATER, AND LAND QUALITY USING CULTURAL TRADITIONS WHILE INTEGRATING INNOVATIONS IN COMBATING CLIMATE CHANGE. THE TRIBAL RESILIENCE HUB WILL NOT ONLY PROVIDE CAREER OPPORTUNITIES BUT PROVIDE A PLACE TO PRESERVE TRADITIONS LIKE COMMUNITY EVENTS, TEACHINGS, TRAININGS, FEASTS, HARVESTING MANOOMIN, MEDICINAL PLANTS, AND OTHER TRADITIONAL FOODS. ACTIVITIES:THE ACTIVITIES INCLUDE TRIBAL STAFF TO BE HIRED TO INTERACT WITH THE COMMUNITY AND PROTECTING THE AIR, WATER, AND LAND QUALITY USING CULTURAL TRADITIONS WHILE INTEGRATING INNOVATIONS IN COMBATING CLIMATE CHANGE. THE TRIBAL RESILIENCE HUB WILL NOT ONLY PROVIDE CAREER OPPORTUNITIES BUT PROVIDE A PLACE TO PRESERVE TRADITIONS LIKE COMMUNITY EVENTS, TEACHINGS, TRAININGS, FEASTS, HARVESTING MANOOMIN, MEDICINAL PLANTS, AND OTHER TRADITIONAL FOODS. SUBRECIPIENT:COLLABORATION WITH THE CLBGC, LLTC, AND TERO WILL COMMENCE EARLY IN THE CONSTRUCTION AND DESIGN PHASES OF THE HUB AND WILL CONTINUE THROUGHOUT ITS PROGRAMMING AND OPERATIONS. YOUTH WILL BE TRANSPORTED TO AND FROM THE SITE YEAR-ROUND USING ELECTRIC VANS, WHICH REDUCE POLLUTION AND FOSSIL FUEL CONSUMPTION. THE VANS WILL ARRIVE AT THE ENTRY AREA (SEE FIGURE 7), WHERE AN EV CHARGING STATION IS LOCATED. ELECTRIC BICYCLES WILL ALSO BE AVAILABLE FOR ACCESSING THE HUB AND NEARBY TRAILS, WITH INFRASTRUCTURE FOR PARKING AND CHARGING NEAR THE ENTRANCE. THE PROJECT FUNDED OUTREACH AND CULTURAL COORDINATORS WILL WORK CLOSELY WITH TRIBAL ELDERS, STAFF, CLBGC, LLTC AND TERO TO DEVELOP AND IMPLEMENT TRAINING AND CLASSES THROUGHOUT THE YEAR. THE CLBGC MEMBERS WILL CONTRIBUTE TO COMMUNITY ENGAGEMENT BY USING SOCIAL MEDIA TO PROMOTE INPUT SESSIONS DURING THE FINAL DESIGN AND CONSTRUCTION PHASES, PARTICIPATE IN TRAIL LAYOUT PLANNING, AND ASSIST IN DESIGNING, PLANNING AND INSTALLATION OF THE EDIBLE PLANTS AND CULTURAL TRADITIONAL DYE GARDENS. CLEAN AIR AND HEALTHY BUILDINGS ARE A PRIORITY FOR THE COMMUNITY AS IS THE CREATION OF A WARM ENTRY AND MULTIPURPOSE SPACE THAT CAN BE USED TO HOST EDUCATIONAL AND TRAINING OPPORTUNITIES AND DISPLAY CULTURALLY SIGNIFICANT ARTIFACTS AS SEEN IN FIGURE 7 BELOW. A DETAILED FLOOR PLAN FOR THE RESILIENCE HUB CAN BE FOUND IN APPENDIX I.OUTCOMES:THE ANTICIPATED DELIVERABLES INCLUDE COLLABORATING WITH THE CLBGC AND LLTC INVESTMENTS IN THE TRIBAL RESILIENCE HUB WILL CREATE A VIBRANT SPACE THAT SUPPORTS COMMUNITY SHARING, TEACHING, ENGAGEMENT, CEREMONIES, AND INTERACTION. IT WILL ALSO MOVE DOZENS OF TRIBAL STAFF MEMBERS OFF A SUPERFUND SITE INTO A PURPOSE-BUILT FACILITY THAT WILL SERVE THE NEEDS OF THESE DEPARTMENTS, ALLOW THE DIVISION TO BUILD CAPACITY, AND HAVE THE FACILITIES AND RESOURCES THEY NEED TO PROTECT ALL THE PLANTS, ANIMALS, AND CULTURAL TRADITIONS OF THE COMMUNITY. FURTHER, WITH THE ADDITION OF THE MUCH-NEEDED OUTREACH AND CULTURAL COORDINATORS, THEY WILL ADVANCE OUR COMMUNITY ENGAGEMENT. THE EXPECTED OUTCOMES INCLUDE THE RESILIENCE HUB BEING A PLACE WHERE CULTURAL ASSETS AND HISTORICAL ITEMS CAN BE RETURNED AND HOUSED. PARTNERSHIPS WITH THE CLBGC, THE LLTC, AND THE RESERVATION COMMUNITY MEMBERS ALLOWS THE TRIBE TO WORK COLLABORATIVELY WITH THESE PARTNERS TO DEVELOP MULTIGENERATIONAL EDUCATIONAL OPPORTUNITIES. THE RESILIENCE HUB CAN SUPPORT THE RESIDENTS IN TIMES OF NEED, ACTING AS AN OPERATIONAL CONTROL CENTER AND/OR INCIDENT COMMAND AND DISTRIBUTION CENTER DURING EMERGENCIES. OVER TIME THE RESILIENCE CAMPUS WILL WEAVE TOGETHER THE FISH HATCHERY, GREENHOUSES, AND OTHER RESOURCES. THE INTENDED BENEFICIARIES ARE DISADVANTAGED COMMUNITIES.

TAS::89 0328::TAS RECOVERY SMART GRID INVESTMENT GRANT PROJECT THE CITY OF LEESBURG IS INNOVATING IN THE SMART GRID INITIATIVE BY INCORPORATING A BR

FY 20 CARES ACT (CORONAVIRUS AID RELIEF AND ECONOMIC SECURITY); LEE CO.; CAPE CORAL/BONITA SPRINGS UZA FL

THE BROADBAND INFRASTRUCTURE DEPLOYMENT PROJECT PROPOSES TO INSTALL FIBER AND FIXED WIRELESS TO DIRECTLY CONNECT 4,399 UNSERVED NATIVE AMERICAN HOUSEHOLDS WITH QUALIFYING BROADBAND SERVICE (FIBER TO THE HOME SERVICE UP TO 100/40 GBPS AND WIRELESS SERVICE UP TO 80/20 MBPS).

USING COMBINATORIAL THERAPIES WITH DENDRITIC CELL THERAPIES TO IMPROVE SURVIVAL AND PREVENT RECURRENCE OF BREAST CANCER LEPTOMENINGEAL DISEASE (LMD)

AIAN HEAD START

NEIGHBORHOOD STABILIZATION PRG

IMPACT AID PROGRAM, TITLE VII, SECTION 7003

IMPROVE EXISTING AIRPORT

HEAD START - FULL YEAR / PART DAY - T/TA

HIGHER EDUCATION EMERGENCY RELIEF FUND-INSTITUTIONAL PORTION

TRIBALLY CONTROLLED COLLEGE ASSISTANCE

THE TOWN OF WELLFLEET WILL BE AWARDED $14.69M TO IMPLEMENT THE FIRST PHASE OF THE HERRING RIVER RESTORATION PROJECT, THE LARGEST SALT MARSH RESTORATION EFFORT IN THE NORTHEAST UNITED STATES. THIS PROJECT WILL SUPPORT CONSTRUCTION OF ALL WATER CONTROL INFRASTRUCTURE NEEDED FOR FULL TIDAL RESTORATION OF THE ESTUARY, AS WELL AS PROPERTY IMPACT PREVENTION MEASURES NEEDED TO BEGIN IMPLEMENTATION OF TIDAL RESTORATION. UPON COMPLETION, THE OVERALL EFFORT WILL RESTORE 890 ACRES OF TIDAL WETLANDS AND RECONNECT A FUNCTIONING ESTUARY TO CAPE COD BAY AND THE GULF OF MAINE. IT WILL SIGNIFICANTLY IMPROVE WATER QUALITY AND HABITAT FOR FISH AND SHELLFISH. REESTABLISHING NATURAL SEDIMENT PROCESSES WILL HELP THE MARSH REGAIN ELEVATION AND KEEP PACE WITH SEA LEVEL RISE. THE EFFORT WILL ALSO HELP RESTORE THE FLOOD AND STORM PROTECTION FUNCTIONS OF HEALTHY SALT MARSH, AND REBUILD AND IMPROVE THE RESILIENCE OF LOCAL BRIDGES AND ROADS.

NATIONAL FUNCTIONAL GENOMICS CENTER

IMPROVE EXISTING AIRPORT

FY 2011 STATE OF GOOD REPAIR

APPLICATION PURPOSE: THE PURPOSE OF THIS AWARD IS TO PROVIDE FOR ELIGIBLE CAPITAL AND OPERATING COSTS FOR LEE COUNTY TRANSIT; ACTIVITIES PERFORMED: THE FUNDING WILL BE USED TO PURCHASE REPLACEMENT FIXED ROUTE BUSES REPLACEMENT AND EXPANSION ADA/PARATRANSIT VANS REPLACEMENT OF SUPPORT VEHICLES PREVENTATIVE MAINTENANCE ASSOCIATED CAPITAL MAINTENANCE PARTS PLANNING SOFTWARE EMPLOYEE EDUCATION SECURITY TRAINING SURVEILLANCE AND THE BUS SHELTER IMPROVEMENTS.; EXPECTED OUTCOMES: FUNDING WILL ALLOW LEE COUNTY TRANSIT TO CONTINUE ITS CAPITAL PROJECTS ALLOWING FOR THE SAFE AND EFFECTIVE OPERATION OF TRANSIT SERVICES.; INTENDED BENEFICIARIES: LEE COUNTY TRANSIT AND THE RIDERS THAT RELY ON ITS SERVICE WILL BENEFIT FROM THE CAPITAL PURCHASES SUPPORTING TRANSIT SERVICES.; SUBRECIPIENT ACTIVITIES: N/A

APPLICATION PURPOSE: THE PURPOSE OF THIS AWARD IS TO PROVIDE FOR ELIGIBLE CAPITAL COSTS FOR LEE COUNTY TRANSIT.; ACTIVITIES PERFORMED: THE FUNDING WILL BE USED TO PURCHASE REPLACEMENT FIXED ROUTE BUSES REPLACEMENT AND EXPANSION ADA/PARATRANSIT VANS REPLACEMENT OF SUPPORT VEHICLES PREVENTATIVE MAINTENANCE ASSOCIATED CAPITAL MAINTENANCE PARTS PLANNING SOFTWARE EMPLOYEE EDUCATION SECURITY TRAINING SURVEILLANCE AND THE BUS SHELTER IMPROVEMENTS.; EXPECTED OUTCOMES: FUNDING WILL ALLOW LEE COUNTY TRANSIT TO CONTINUE ITS CAPITAL PROJECTS ALLOWING FOR THE SAFE AND EFFECTIVE OPERATION OF TRANSIT SERVICES.; INTENDED BENEFICIARIES: LEE COUNTY TRANSIT AND THE RIDERS THAT RELY ON ITS SERVICE WILL BENEFIT FROM THE CAPITAL PURCHASES SUPPORTING TRANSIT SERVICES.; SUBRECIPIENT ACTIVITIES: N/A

PURPOSE: THE PURPOSE OF THE AWARD IS TO PROVIDE 3 YEARS OF OPERATING ASSISTANCE TO LEE COUNTY TRANSIT TO ASSIST IT IN RECOVERING FROM COVID-19 DURING THE PERIOD OF OCTOBER 1 2021 TO JUNE 30 2024. ACTIVITIES TO BE PERFORMED: FUNDS WILL BE USED TO COVER ALL ELIGIBLE OPERATING EXPENSES SUCH AS DRIVER SALARIES FUEL ITEMS HAVING A USEFUL LIFE OF LESS THAN ONE YEAR PREVENTIVE MAINTENANCE ETC. IN ORDER TO CONTINUE TRANSIT OPERATIONS. EXPECTED OUTCOMES: FUNDING WILL PERMIT LEE COUNTY TRANSIT TO CONTINUE TO PROVIDE UNINTERRUPTED OPERATIONS AND AVOID REDUCTIONS IN SERVICES. INTENDED BENEFICIARIES: THIS PROJECT WILL BENEFIT LEE COUNTY TRANSIT AND THE RIDERS THAT RELY ON ITS SERVICE WILL BENEFIT FROM CONTINUED SERVICES PERMITTING WORKERS TO GET TO WORK AND RIDERS TO GET TO ESSENTIAL SERVICES. SUBRECIPIENT ACTIVITIES: NONE. THIS IS AN FFY 2021 SECTION 5307 ARP FUNDING APPLICATION FOR THE CAPE CORAL UZA IN THE AMOUNT OF $12573329 AND THE BONITA SPRINGS UZA IN THE AMOUNT OF $201415 FOR A TOTAL AMOUNT OF $12774744 REPRESENTING 100% FEDERAL SHARE OF THE TOTAL ELIGIBLE AMOUNT. THIS APPLICATION UTILIZES ARP FUNDING TO PREVENT PREPARE FOR AND RESPOND TO CORONAVIRUS. THE APPLICATION SCOPE OF WORK INCLUDES OPERATING ASSISTANCE FOR THE PROVISION OF TRANSIT SERVICE TO INCLUDE PAYROLL AND OPERATIONAL EXPENSES OF PROVIDING PUBLIC TRANSIT SERVICE. THE SPLIT LETTER DATED AUGUST 30 2021 IS ATTACHED IN TRAMS. LEE COUNTY TRANSIT AGREES THAT IF IT RECEIVES FEDERAL FUNDING FROM THE FEDERAL EMERGENCY MANAGEMENT (FEMA) OR THROUGH A PASS-THROUGH ENTITY THROUGH THE ROBERT T. STAFFORD DISASTER RELIEF AND EMERGENCY ASSISTANCE ACT A DIFFERENT FEDERAL AGENCY OR INSURANCE PROCEEDS FOR ANY PORTION OF A PROJECT ACTIVITY APPROVED FOR FTA FUNDING UNDER THIS GRANT AGREEMENT IT WILL PROVIDE WRITTEN NOTIFICATION TO FTA AND REIMBURSE FTA FOR ANY FEDERAL SHARE THAT DUPLICATES FUNDING PROVIDED BY FEMA ANOTHER FEDERAL AGENCY OR AN INSURANCE COMPANY. PER ARP THE PROJECTS IN THIS APPLICATION ARE NOT REQUIRED TO BE PROGRAMMED IN THE LONG-RANGE TRANSPORTATION PLAN STATEWIDE TRANSPORTATION PLAN OR STATEWIDE TRANSPORTATION IMPROVEMENT PROGRAM. LEE COUNTY TRANSIT WILL NOT EXPEND AT LEAST 1% OF THE 5307 FUNDS IN THIS APPLICATION FOR SECURITY-RELATED PROJECTS UNDER ALI 11.7K04 AS FUNDING HAS BEEN ALLOCATED IN THE FFY20 AND FFY21 5307 APPLICATIONS. FOR THIS REASON ADDITIONAL SECURITY TRAINING FUNDING IS UNNECESSARY.LEE COUNTY TRANSIT WILL FOLLOW ALL 3RD PARTY PROCUREMENT POLICIES AS DEFINED IN C4220.1F (THIRD PARTY CONTRACTING GUIDANCE).LEE COUNTY TRANSIT WILL ENSURE CONTRACTORS PROCURED WILL NOT BE ON THE FTA SUSPENSION AND DEBARMENT LIST. THE OPERATING EXPENSES REQUESTED IN THIS APPLICATION WERE DETERMINED BY PRIOR YEAR EXPENSES INCURRED FOR OPERATING TRANSIT SERVICES. LEE COUNTY TRANSIT UNDERSTANDS THAT THE EXPENSES REQUESTED IN THIS APPLICATION ARE SUBJECT TO REVIEW FOR THEIR REASONABLENESS AS PART OF THE AGENCYS NEXT TRIENNIAL/STATE MANAGEMENT REVIEW.

CANCER AS A COMPLEX ADAPTIVE SYSTEM

RIGOROUS AND ENGAGING ACADEMIC PROGRAMS (REAP) MAGNET PROJECT

PURPOSE: EXPAND APRON. ACTIVITIES TO BE PERFORMED/EXPECTED OUTCOMES: THIS PROJECT EXPANDS THE EXISTING CONCOURSE E APRON AN ADDITIONAL 80,000 SQUARE YARDS TO ACCOMMODATE MORE PASSENGERS. THIS GRANT FUNDS PHASE 3, WHICH CONSISTS OF 56,000 SQUARE YARDS OF CONSTRUCTION. INTENDED BENEFICIARY: THIS GRANT WILL PROVIDE FEDERAL FUNDING FOR AIRPORTS ASSOCIATED WITH FORT MYERS, FLORIDA.

APPLICATION PURPOSE: THE FUNDING WILL BE USED TO PURCHASE REPLACEMENT FIXED ROUTE BUSES REPLACEMENT AND EXPANSION ADA/PARATRANSIT VANS REPLACEMENT OF SUPPORT VEHICLES PREVENTATIVE MAINTENANCE ASSOCIATED CAPITAL MAINTENANCE PARTS PLANNING SOFTWARE EMPLOYEE EDUCATION SECURITY TRAINING SURVEILLANCE AND THE BUS SHELTER IMPROVEMENTS.; ACTIVITIES PERFORMED: FUNDING WILL ALLOW LEE COUNTY TRANSIT TO CONTINUE ITS CAPITAL PROJECTS ALLOWING FOR THE SAFE AND EFFECTIVE OPERATION OF TRANSIT SERVICES.; EXPECTED OUTCOMES: FUNDING WILL ALLOW LEE COUNTY TRANSIT TO CONTINUE ITS CAPITAL PROJECTS ALLOWING FOR THE SAFE AND EFFECTIVE OPERATION OF TRANSIT SERVICES.; INTENDED BENEFICIARIES: LEE COUNTY TRANSIT AND THE RIDERS THAT RELY ON ITS SERVICE WILL BENEFIT FROM THE CAPITAL PURCHASES SUPPORTING TRANSIT SERVICES.; SUBRECIPIENT ACTIVITIES: N/A

HIGHER EDUCATION EMERGENCY RELIEF FUND FOR DIRECT STUDENT AID

NATURAL HISTORY OF HPV INFECTION IN MEN: THE HIM STUDY

LEE UNIVERSITY - CARES ACT HIGHER EDUCATION EMERGENCY RELIEF FUND

APPLICATION PURPOSE: THE PURPOSE OF THIS AWARD IS TO PROVIDE FOR ELIGIBLE CAPITAL COSTS FOR LEE COUNTY TRANSIT.; ACTIVITIES PERFORMED: THE FUNDING WILL BE USED TO PURCHASE REPLACEMENT FIXED ROUTE BUSES REPLACEMENT AND EXPANSION ADA/PARATRANSIT VANS REPLACEMENT OF SUPPORT VEHICLES PREVENTATIVE MAINTENANCE ASSOCIATED CAPITAL MAINTENANCE PARTS PLANNING SOFTWARE EMPLOYEE EDUCATION SECURITY TRAINING SURVEILLANCE AND THE BUS SHELTER IMPROVEMENTS.; EXPECTED OUTCOMES: FUNDING WILL ALLOW LEE COUNTY TRANSIT TO CONTINUE ITS CAPITAL PROJECTS ALLOWING FOR THE SAFE AND EFFECTIVE OPERATION OF TRANSIT SERVICES.; INTENDED BENEFICIARIES: LEE COUNTY TRANSIT AND THE RIDERS THAT RELY ON ITS SERVICE WILL BENEFIT FROM THE CAPITAL PURCHASES SUPPORTING TRANSIT SERVICES.; SUBRECIPIENT ACTIVITIES: N/A

SPORE IN LUNG CANCER

BIPARTISAN INFRASTRUCTURE LAW (BIL) - SCALING VEHICLE-TO-GRID INTEGRATION NATIONALLY (SVIN) THE PURPOSE OF THIS PROJECT IS TO SUCCESSFULLY DEPLOY 44 VEHICLE-TO-GRID (V2G) CHARGERS, 500 KILOWATT-HOURS (KWH) OF STATIONARY STORAGE, 800 KILOWATTS (KW) OF SOLAR, AND ASSOCIATED INFRASTRUCTURE ACROSS 14 SITES. THE PROJECT WILL ALSO ESTABLISH THREE SOLAR PLUS STORAGE SUPPORTED AND ONE STORAGE-ONLY SUPPORTED SYSTEMS. THE PROJECT WILL ALSO PERFORM ANNUAL IMPACT ASSESSMENTS ON THE RATE OF V2G ENABLED ELECTRIC VEHICLE ADOPTION AND GRID INTEGRATION, AND GRID BENEFITS.

EWP PROJECT 5078. FL, COUNTY OF LEE, DSR 12-19-22-5078-054 IAN-LEE-001, DEBRIS REMOVAL DUE TO HURRICANE IAN

CORRECTING THE ANTI-HER-2 CD4 TH1 RESPONSE IN BREAST CANCER THERAPY TO PREVENT RECURRENCE

IMPROVE EXISTING AIRPORT REHABILITATE RUNWAY [REHAB RUNWAY 6/24]

HEAD START AND EARLY HEAD START

INSTITUTIONAL PORTION OF THE HIGHER EDUCATION EMERGENCY RELIEF FUND, SECTION 18004(A)(1) AND 18004(C) OF THE CORONAVIRUS AID, RELIEF, AND ECONOMIC SECURITY (CARES) ACT FOR BERKLEE COLLEGE OF MUSIC

INCREASING DIVERSITY AND ACHIEVEMENT THROUGH RIGOROUS AND ENGAGING (I-DARE) PROGRAMS PROJECT

FOLLOW-UP OF OVARIAN CANCER GENETIC ASSOCIATION AND INTERACTION STUDIES (FOCI)

LEE COUNTY COMPLETE ST INITIATIVE

IDENTIFYING METABOLIC VULNERABILITIES IN LUNG CANCER - OVERALL PROJECT SUMMARY IDENTIFYING METABOLIC VULNERABILITIES IN LUNG CANCER LUNG CANCER IS THE MOST COMMON CAUSE OF CANCER DEATHS WORLD-WIDE. TYROSINE KINASE INHIBITORS AND IMMUNOTHERAPY HAVE BEEN SHOWN TO BE EFFECTIVE IN A SUBSET OF PATIENTS; HOWEVER, THE OVERALL SURVIVAL RATE FOR THIS DISEASE REMAINS LOW ESPECIALLY FOR METASTATIC DISEASE. MOREOVER, SMALL CELL LUNG CANCER (SCLC) PATIENTS HAVE A POOR PROGNOSIS, AND THERE ESPECIALLY EXISTS A GAP IN KNOWLEDGE IN UNDERSTANDING SCLC AND IDENTIFYING EFFECTIVE THERAPEUTIC STRATEGIES. OUR GOAL IN THIS PROPOSAL IS TO UNDERSTAND THE UNDERLYING BIOLOGY OF KEY DRIVERS IN LUNG CANCER BY IDENTIFYING METABOLIC VULNERABILITIES THAT CAN ULTIMATELY BE USED AS SINGLE AGENTS OR COMBINED WITH IMMUNOTHERAPY TO TARGET LUNG CANCER THERAPEUTICALLY. WE WILL ACHIEVE THIS GOAL BY ENGAGING EXPERTS THAT HAVE DEVELOPED PRECLINICAL MODELS WITH COMMON MOLECULAR SIGNATURES IN NON-SMALL CELL (NSCLC) AND SMALL CELL LUNG CANCER (SCLC) AND CUTTING-EDGE METABOLOMICS. WE HAVE AN ACTIVE AND COLLABORATIVE GROUP THAT MEETS TWICE MONTHLY WITH PROJECTS AND MANUSCRIPTS THAT ARE CO-AUTHORED BY THE LEADERS OF EACH PROJECT AND CORE. ADDITIONALLY, OUR PROGRAM PROJECT GRANT (PPG) TEAM IS LOCATED AT MOFFITT CANCER CENTER, WHICH IS AN IDEAL PLACE TO STUDY THE PATHOGENESIS OF LUNG CANCER. FLORIDA IS NUMBER 2 IN THE COUNTRY IN TERMS OF NEWLY DIAGNOSED LUNG CANCER PATIENTS. MOFFITT TREATS 10% OF THESE CASES. THE PPG CONSISTS OF FOUR PROJECTS AND FOUR CORES. THESE PROJECTS AND CORES COLLABORATE AND SYNERGIZE TO MEET FOUR OBJECTIVES: I. TO IDENTIFY METABOLIC VULNERABILITIES IN LUNG CANCERS THROUGH INTEGRATIVE ANALYSIS OF IN VIVO AND EX VIVO MODELS WITH COMMON MOLECULAR SIGNATURES, INCLUDING P53, NRF2/KEAP1, AND MYC (PROJECT #1, LED BY DR. FLORES, PROJECT #2, LED BY DR. DENICOLA, PROJECT #3, LED BY DRS. CLEVELAND AND HAURA, AND PROJECT #4, LED BY DR. RODRIGUEZ WITH SUPPORT FROM THE ADMINISTRATIVE CORE #1, LED BY DRS. FLORES AND HAURA, PRECLINICAL MODELS AND PATHOLOGY CORE #2, LED BY DRS. CRESS AND KARRETH, METABOLISM CORE #3, LED BY DR. KOOMEN, AND DATA SCIENCE CORE #4, LED BY DR. FRIDLEY), II. TO IDENTIFY METABOLIC VULNERABILITIES THAT SYNERGIZE WITH IMMUNOTHERAPY THROUGH EXAMINING THE TUMOR MICROENVIRONMENT AND GAINING A DEEP MOLECULAR UNDERSTANDING OF MYELOID DERIVED SUPPRESSOR CELLS (MDSCS). (PROJECT #4 IN COLLABORATION WITH PROJECTS #1 AND #2 AND CORE #2), III. TO BUILD MOUSE MODELS AS A PLATFORM TO UNDERSTAND THE METABOLIC PATHWAYS UTILIZED BY LUNG CANCERS WITH DIFFERENT GENETIC SIGNATURES AND TO ASSESS THERAPEUTIC STRATEGIES FOR LUNG CANCER. (CORE #2 SUPPORTING PROJECTS #1-4), AND IV. TO SHARE RESOURCES AND DATA LOCALLY AND GLOBALLY TO OBTAIN AN INTEGRATED MOLECULAR UNDERSTANDING OF METABOLIC VULNERABILITIES IN LUNG CANCER. (CORE #4 LEADING EFFORTS FROM ALL PROJECTS AND CORES).

PURPOSE: EXPAND TERMINAL. ACTIVITIES TO BE PERFORMED/EXPECTED OUTCOMES: THIS PROJECT EXPANDS THE EXISTING TERMINAL E BY 297,000 SQUARE FEET. THIS GRANT FUNDS NINE PASSENGER BOARDING BRIDGES. THE EXPANSION WILL ACCOMMODATE MORE PASSENGERS. THIS GRANT FUNDS PHASE 2, WHICH CONSISTS OF THE CONSTRUCTION OF NINE PASSENGER BOARDING BRIDGES. INTENDED BENEFICIARY: THIS GRANT WILL PROVIDE FEDERAL FUNDING FOR AIRPORTS ASSOCIATED WITH FORT MYERS, FLORIDA.

IMPROVE EXISTING AIRPORT

THE PHYSICAL MICROENVIRONMENT IN CANCER BIOLOGY AND THERAPY

PURPOSE: THE PURPOSE OF THIS AWARD IS TO PROVIDE FOR ELIGIBLE CAPITAL COSTS FOR LEE COUNTY TRANSIT. ACTIVITIES TO BE PERFORMED: THE FUNDING WILL BE USED TO PURCHASE REPLACEMENT FIXED ROUTE BUSES REPLACEMENT AND EXPANSION ADA/PARATRANSIT VANS REPLACEMENT OF SUPPORT VEHICLES PREVENTATIVE MAINTENANCE ASSOCIATED CAPITAL MAINTENANCE PARTS NON-FIXED ADA PARATRANSIT SERVICE PLANNING SOFTWARE EMPLOYEE EDUCATION SECURITY TRAINING BUS STOP IMPROVEMENTS.EXPECTED OUTCOMES: FUNDING WILL ALLOW LEE COUNTY TRANSIT TO CONTINUE ITS CAPITAL PROJECTS ALLOWING FOR THE SAFE AND EFFECTIVE OPERATION OF TRANSIT SERVICES. INTENDED BENEFICIARIES: LEE COUNTY TRANSIT AND THE RIDERS THAT RELY ON ITS SERVICE WILL BENEFIT FROM THE CAPITAL PURCHASES SUPPORTING TRANSIT SERVICES. SUBRECIPIENT ACTIVITIES: NONETHIS IS A SUPER GRANT APPLICATION FOR FFY 2021 SECTION 5307 FUNDING IN THE AMOUNT OF $6734770; SECTION 5307 FLEX FUND TRANSFER IN THE AMOUNT OF $1500000; AND 5339 IN THE AMOUNT OF $696584. THIS GRANT WILL BE MATCHED WITH TRANSPORTATION DEVELOPMENT CREDITS.THE SECTION 5307 FUNDING INCLUDES THE FFY2021 APPORTIONMENT FOR THE CAPE CORAL UZA IN THE AMOUNT OF $6390138 AND $344632 FOR THE UZA TRANSFER FROM THE BONITA SPRINGS UZA WHICH TOTALS $6734770 AND LOCAL PROGRAM INCOME OF $152222. THE BONITA SPRINGS UZA SPLIT LETTER AND LOCAL PROGRAM INCOME DOCUMENTATION ARE ATTACHED. THE FUNDING WILL BE USED TO PURCHASE REPLACEMENT FIXED ROUTE BUSES REPLACEMENT AND EXPANSION ADA/PARATRANSIT VANS REPLACEMENT OF SUPPORT VEHICLES PREVENTATIVE MAINTENANCE ASSOCIATED CAPITAL MAINTENANCE PARTS NON-FIXED ADA PARATRANSIT SERVICE PLANNING SOFTWARE EMPLOYEE EDUCATION SECURITY TRAINING BUS STOP IMPROVEMENTS. TRANSPORTATION DEVELOPMENT CREDITS (TDC) IN THE AMOUNT OF $1683693 WILL BE USED AS SOFT MATCH FOR THE SECTION 5307 FUNDING (REFER TO FDOT TDC LETTER PROJECT# 410147-1). LEE COUNTY TRANSIT IS THE DESIGNATED RECIPIENT OF 5307 PROGRAM FUNDS. THE SECTION 5307 FLEX FUNDS TRANSFER FUNDING IN THE AMOUNT OF $1500000 WILL BE USED FOR THE PURCHASE OF 3 REPLACEMENT FIXED ROUTE BUSES. THIS APPLICATION IS FOR THE USE OF FHWAS FLEX FUNDS TO PURCHASE 3 REPLACEMENT BUSES. THE FUNDING WILL BE USED TO REPLACE THREE (3) FIXED ROUTE BUSES THAT HAVE MET THEIR USEFUL LIFE. THE USEFUL LIFE OF THE REPLACEMENT BUSES ARE 500000 MILES OR 12 YEARS. THE FLEET INFORMATION AND VEHICLE REPLACEMENT SCHEDULE ARE ATTACHED. THIS GRANT WILL BE SOFT-MATCHED WITH FDOTS TRANSPORTATION DEVELOPMENT CREDIT (TDC) IN THE AMOUNT OF $375000 (REFER TO FDOT TDC LETTER PROJECT# 438153-1). THE STATE OF FLORIDA HAS TRANSFERRED FHWA FLEX FUNDING OF $1500000 TO LEE COUNTY. A COPY OF FHWA FORM 1575C IS ATTACHED. THE SECTION 5339 FUNDING INCLUDES THE FFY2021 APPORTIONMENT IN THE AMOUNT OF 696584. THIS APPLICATION IS FOR THE REPLACEMENT OF ADA/PARATRANSIT VANS THAT MET THE USEFUL LIFE. TDCS IN THE AMOUNT OF $174146 WILL BE USED AS SOFT MATCH. THE TDC APPROVAL LETTER FROM THE STATE OF FLORIDA DEPARTMENT OF TRANSPORTATION IS ATTACHED TO THIS APPLICATION. LEE COUNTY WILL ENSURE THAT ALL VEHICLES PURCHASED ARE ACCESSIBLE PURCHASED FROM AN FTA APPROVED TVM AND REPORT TO FTA AFTER CONTRACT IS SIGNED. LEE COUNTY WILL CHECK THE CURRENT LISTING OF TRANSIT VEHICLE MANUFACTURERS ON FTA WEBSITE TO ENSURE EACH IS LISTED AS A CERTIFIED TVM IN COMPLIANCE WITH FTA REGULATIONS. LEE COUNTY WILL FOLLOW ALL 3RD PARTY PROCUREMENT POLICIES AS DEFINED IN FTA CIRCULAR C4220.1F (THIRD PARTY CONTRACTING GUIDANCE).LEE COUNTY WILL ENSURE IT MEETS ALL BUY AMERICA REQUIREMENTS FOR VEHICLES AND ANY OTHER EQUIPMENT PURCHASES. LEE COUNTY WILL ENSURE CONTRACTORS PROCURED WILL NOT BE ON THE FTA SUSPENSION AND DEBARMENT LIST.

SPECIAL DIABETES PROGRAMS FOR INDIANS

HEAD START PROGRAM

THE INCREASING DIVERSITY AND ACHIEVEMENT THROUGH RIGOROUS AND ENGAGING (I-DARE) PROGRAMS PHASE II PROJECT

LEE UNIVERSITY - CARES ACT HIGHER EDUCATION EMERGENCY RELIEF FUND

PURPOSE: REHABILITATE ACCESS ROAD; IMPROVE/MODIFY/REHABILITATE SERVICE ROAD. ACTIVITIES TO BE PERFORMED/EXPECTED OUTCOMES: THIS PROJECT REHABILITATES AN EXISTING ON-AIRPORT ROADWAY TO PROVIDE A PATH FOR AIRCRAFT RESCUE FIREFIGHTING TRUCKS, AIRPORT VEHICLES, OR GROUND SERVICE EQUIPMENT TO OPERATE WITHOUT ENTERING MOVEMENT AREAS. . THIS PROJECT REHABILITATES 121,440 FEET OF THE EXISTING AIRPORT ACCESS ROAD TO EXTEND ITS USEFUL LIFE. . INTENDED BENEFICIARY: THIS GRANT WILL PROVIDE FEDERAL FUNDING FOR AIRPORTS ASSOCIATED WITH FORT MYERS, FLORIDA.

BERKLEE COLLEGE OF MUSIC WOULD LIKE TO USE THE CARES HIGHER EDUCATION EMERGENCY RELIEF FUND TO ASSIST OUR STUDENTS WHO HAD UNEXPECTED EXPENSES ARISE FROM OUR CAMPUS CLOSURE DUE TO COVID-19.

HEAD START

MOFFITT SKIN CANCER SPORE

APPLICATION PURPOSE: FEDERAL PUBLIC TRANSPORTATION LAW (49 U.S.C 5324) PROVIDES FTA WITH THE AUTHORITY TO REIMBURSE PUBLIC TRANSPORTATION EMERGENCY RESPONSE AND RECOVERY COSTS AFTER AN EMERGENCY OR MAJOR DISASTER THAT AFFECTS PUBLIC TRANSPORTATION SYSTEMS WHEN FUNDING IS APPROPRIATED. THE PURPOSE OF THIS AWARD IS TO PROVIDE FOR ELIGIBLE CAPITAL OPERATING COSTS INCURRED AS A RESULT OF THE DAMAGES FROM HURRICANE IAN-2022 FOR LEE COUNTY TRANSIT.; ACTIVITIES PERFORMED: THE FUNDING WILL BE USED TO REIMBURSE CAPITAL AND OPERATING COSTS ASSOCIATED WITH DAMAGED FACILITIES (REPAIR AND MITIGATION OF DAMAGES) MITIGATION OF UNDAMAGED FACILITIES OPERATING LABOR COSTS AND EQUIPMENT USAGE. DAMAGES WERE DUE TO THE EFFECTS OF HURRICANE IAN-2022.; EXPECTED OUTCOMES: FUNDING WILL ALLOW LEE COUNTY TRANSIT TO CONTINUE ITS CAPITAL PROJECTS ALLOWING FOR THE SAFE AND EFFECTIVE OPERATION OF TRANSIT SERVICES.; INTENDED BENEFICIARIES: LEE COUNTY TRANSIT AND THE RIDERS THAT RELY ON ITS SERVICES WILL BENEFIT FROM THE REIMBURSEMENT OF THE RESPONSE AND RECOVERY COSTS ASSOCIATED WITH HURRICANE IAN-2022.; SUBRECIPIENT ACTIVITIES: N/A

NOVEL IMMUNOTHERAPY FOR BRAIN-METASTATIC BREAST CANCER

PURPOSE: EXPAND/EXTEND TERMINAL ACCESS ROAD. ACTIVITIES TO BE PERFORMED/EXPECTED OUTCOMES: THIS PROJECT EXPANDS AN EXISTING TERMINAL ACCESS ROAD BY ADDING AN OFF RAMP AND THREE TRAFFIC LANES TO ACCOMMODATE MORE VEHICULAR TRAFFIC EXCLUSIVELY SERVING THE AIRPORT. THIS GRANT FUNDS PHASE 2, WHICH CONSISTS OF CONSTRUCTION OF THE OFF RAMP AND THREE TRAFFIC LANES. INTENDED BENEFICIARY: THIS GRANT WILL PROVIDE FEDERAL FUNDING FOR AIRPORTS ASSOCIATED WITH FORT MYERS, FLORIDA.

TARGETING SIGNAL TRANSDUCTION PATHWAYS FOR CANCER DRUG DISCOVERY

MOFFITT IMAGING BIOMARKER VALIDATION CENTER

WILDLAND FIRE MANAGEMENT - NON-RECURRING FUNDS

IMPROVE EXISTING AIRPORT

THIS IS AN FFY 2020 SECTION 5307 APPLICATION IN THE AMOUNT OF $6722208 FOR FEDERAL FUNDING AND PROGRAMMING OF THE PROJECTS. THE FUNDING AMOUNT INCLUDES FFY 20 APPORTIONMENT FOR THE UZA CAPE CORAL (UZA # 123610) IN THE AMOUNT OF $6404308 THE UZA TRANSFER OF $363977 FROM THE UZA BONITA SPRINGS (UZA # 123610) LOCAL PROGRAM INCOME OF $138091 AND $46077 LOCAL SHARE FOR FEDERAL INTEREST DUE. THE FULL FEDERAL APPORTIONMENT OF $6404308 FOR THE CAPE CORAL UZA AND $363977 FOR THE BONITA SPRINGS UZA TOTALS $6768285. THE BONITA SPRINGS UZA SPLIT LETTER AND LOCAL PROGRAM INCOME DOCUMENTATION ARE ATTACHED. THE FUNDING WILL BE USED TO BUY REPLACEMENT FIXED ROUTE BUSES REPLACEMENT ADA/PARATRANSIT VANS REPLACEMENT OF STAFF VEHICLES PREVENTATIVE MAINTENANCE ASSOCIATED CAPITAL MAINTENANCE PARTS NON FIXED ADA PARATRANSIT SERVICE PLANNING SOFTWARE EMPLOYEE EDUCATION AND SECURITY TRAINING.LEE COUNTY WILL ENSURE THAT ALL VEHICLES PURCHASED ARE ACCESSIBLE PURCHASED FROM AN FTA APPROVED TVM AND REPORTED TO FTA WITHIN 30 DAYS AFTER CONTRACT IS SIGNED. LEE COUNTY WILL CHECK THE CURRENT LISTING OF TRANSIT VEHICLE MANUFACTURES (ON FTA WEBSITE) TO ENSURE EACH IS LISTED AS A CERTIFIED TVM IN COMPLIANCE WITH FTA REGULATIONS.LEE COUNTY WILL FOLLOW ALL 3RD PARTY PROCUREMENT POLICIES AS DEFINED IN FTA CIRCULAR C4220.1F (THIRD PARTY CONTRACTING GUIDANCE).LEE COUNTY WILL ENSURE CONTRACTORS PROCURED WILL NOT BE ON THE FTA SUSPENSION AND DEBARMENT LIST.TRANSPORTATION DEVELOPMENT CREDITS (TDC) IN THE AMOUNT OF $1692071 WILL BE USED AS A SOFT MATCH. THE TDC APPROVAL LETTER FOR THE STATE OF FLORIDA DEPARTMENT OF TRANSPORTATION IS ATTACHED TO THIS APPLICATION.

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PURPOSE: EXPAND APRON. ACTIVITIES TO BE PERFORMED/EXPECTED OUTCOMES: THIS PROJECT EXPANDS AN EXISTING CONCOURSE E APRON AN ADDITIONAL 80,000 SQUARE YARDS TO ACCOMMODATE MORE PASSENGERS. THIS GRANT FUNDS PHASE 2, WHICH CONSISTS OF 24,250 SQUARE YARDS OF CONSTRUCTION. INTENDED BENEFICIARY: THIS GRANT WILL PROVIDE FEDERAL FUNDING FOR AIRPORTS ASSOCIATED WITH FORT MYERS, FLORIDA.

COMMUNITY DEVELOPMENT BLOCK GRANTS/ENTITLEMENT GRANTS

FY 2013 USC 5307 URBANIZED AREA FOR

5307 CAPITAL AND OPERATING ASSISTANCE - LEE COUNTY FLORIDA

IDENTIFICATION OF NON-CODING RNAS TO THERAPEUTICALLY TARGET UNDRUGGABLE PATHWAYS IN METASTATIC LUNG ADENOCARCINOMA AND SQUAMOUS CELL CARCINOMA

THE DELTA ECOLOGY OF NSCLC TREATMENT - SUMMARY – MOFFITT CSBC PROPOSAL OVERVIEW THE MOFFITT CSBC PROPOSAL IS FOCUSED ON THE ESSENTIAL AND HIGHLY DYNAMICAL INTERPLAY BETWEEN CANCER CELL EVOLUTION AND THE CONSTANTLY CHANGING ECOLOGY OF THE LUNG MICROENVIRONMENT. TUMORS ARE NOT SIMPLY COLLECTIONS OF MUTATED CELLS THAT GROW IN ISOLATION. RATHER, THEY RESPOND TO AND MODIFY BOTH THE PHYSICAL MICROENVIRONMENT AND A VARIETY OF HOST CELLS, AND THESE CHANGES IN ECOLOGY (“-ECOLOGY”) ARE KEY TO UNDERSTANDING TUMOR PROGRESSION AND THE RESPONSE TO THERAPY – PARTICULARLY THE DEVELOPMENT OF RESISTANCE. CENTRAL TO THIS PROPOSAL IS QUANTIFYING, UNDERSTANDING, AND ACTIONING THE CHANGE THAT OCCURS DURING TREATMENT TO BOTH THE TUMOR AND NON-TUMOR ECOLOGY IN NON-SMALL CELL LUNG CANCER (NSCLC), WHICH IS THE MOST COMMON AND AMONG THE MOST LETHAL OF HUMAN CANCERS. WE WILL DEFINE THE ECOLOGICAL AND EVOLUTIONARY DYNAMICS THAT GOVERN NSCLC PROGRESSION AND TREATMENT SUCCESS OR FAILURE THROUGH 2 PROJECTS AND 2 SHARED RESOURCE CORES. EACH PROJECT WILL FOCUS ON DIFFERENT D-ECOLOGY DYNAMICS IN THE PRESENCE OF DIFFERENT DRIVER MUTATIONS (RAS, EGFR, ALK) FOR WHICH TARGETED THERAPY IS AVAILABLE. EACH PROJECT DEMONSTRATES OUR UNIFYING THEME OF TIGHT EMPIRICAL/MATHEMATICAL INTEGRATION THROUGH THE SEQUENCE OF DEVELOP, PREDICT, CALIBRATE, TEST, OPTIMIZE, AND VALIDATE. THUS, EACH PROJECT BEGINS WITH AVAILABLE CLINICAL DATA FOLLOWED BY IN SILICO (PREDICT AND OPTIMIZE), IN VITRO (CALIBRATE AND TEST) AND IN VIVO (VALIDATE) MODEL SYSTEMS LEADING TO READILY TRANSLATABLE TREATMENT OPTIONS. THE MATHEMATICAL AND ECOLOGICAL CORES INCORPORATE THE MATHEMATICAL AND COMPUTATIONAL METHODS NEEDED FOR BRIDGING THE PROJECTS. THE MATH CORE WILL SERVE AS THE MECHANISTIC MODEL ENGINE OF THE CENTER, FACILITATING BOTH SPATIAL AND NON-SPATIAL MODELS OF ECO-EVOLUTIONARY PROCESSES TO GENERATE AND TEST HYPOTHESES REGARDING - ECOLOGY. THE ECOLOGY CORE SERVES AS DATA REPOSITORY AND ECOLOGICAL ANALYSIS ENGINE WORKING IN LOCKSTEP WITH THE THREE PROJECTS FOCUSED ON DIFFERENT ASPECTS OF NSCLC -ECOLOGY (IMMUNE AND STROMAL) TO DEVELOP AND APPLY SPATIAL ECOLOGICAL MODELS. THESE CORES WILL SERVE OUR TWO PROJECTS: PROJECT 1: DELTA IMMUNE ECOLOGY OF NSCLC 1.1 QUANTIFY THE -ECOLOGY OF PATIENT SAMPLES PRE- AND ON- TREATMENT TO PREDICT OUTCOMES; 1.2 IMPACT OF KRAS INHIBITOR THERAPY WITH IMMUNOTHERAPY ON LUNG TUMOR ECOLOGY; 1.3 USE PREDICTIVE MODELING TO GENERATE EVOLUTIONARY INSPIRED MULTI-AGENT TREATMENT STRATEGIES. PROJECT 2: DELTA STROMAL ECOLOGY OF NSCLC 2.1 DECIPHER, IN VIVO, THE -ECOLOGY OF ACQUIRED RESISTANCE TO TARGETED THERAPIES IN NSCLC; 2.2 DEFINE THE IMPACT OF STROMAL SHELTERING ON THE EMERGENCE OF RESISTANCE AND TUMOR GROWTH RELAPSE; 2.3 DISCOVER OPTIMAL THERAPEUTIC STRATEGIES TO SUPPRESS RESISTANCE.

5307 CAPITAL AND OPERATING ASSISTANCE - LEE COUNTY FLORIDA

IMPROVE EXISTING AIRPORT

FY 17 5307 URBANIZED AREA FORMULA GRANT

PURPOSE: REHABILITATE TAXIWAY. ACTIVITIES TO BE PERFORMED/EXPECTED OUTCOMES: THIS PROJECT REHABILITATES 11,320 FEET OF THE EXISTING TAXIWAY B NEEDED TO EXTEND THE USEFUL LIFE OF THE PAVEMENT. THIS GRANT FUNDS THE FINAL PHASE, WHICH CONSISTS OF CONSTRUCTION OF 11,320 FEET. INTENDED BENEFICIARY: THIS GRANT WILL PROVIDE FEDERAL FUNDING FOR AIRPORTS ASSOCIATED WITH KILLEEN, TEXAS.

HAPLOTYPE-BASED GENOME SCREEN FOR OVARIAN CANCER LOCI

LEECH LAKE BANK OF OJIBWE/BUG-O-NAY-GE-SHIG-SCHOOL

FY 2014 USC 5307 URBANIZED AREA FOR

25 ARRA VEHICLES,PM, ADP & TRANSIT

FY 15 5307 URBANIZED AREA FORMULA GRANT

ROLE OF BCL11B IN CD4+ T CELLS

FY 16 5307 URBANIZED AREA FORMULA GRANT

RADIOMICS OF NSCLC

INDIAN HSG BLOCK GR

LURLEEN B. WALLACE COMMUNITY COLLEGE INSTITUTIONAL FUNDING

CAUSES AND CONSEQUENCES OF ACID PH IN TUMORS

PURPOSE: RECONSTRUCT TERMINAL. ACTIVITIES TO BE PERFORMED/EXPECTED OUTCOMES: THIS PROJECT RECONSTRUCTS THE EXISTING TERMINAL BY REPLACING BAGGAGE CLAIM CAROUSELS AND THE AIRPORT EMERGENCY GENERATOR THAT HAVE REACHED THE END OF THEIR USEFUL LIVES. THIS PROJECT WILL FUND THE FINAL PHASE, WHICH CONSISTS OF CONSTRUCTION. INTENDED BENEFICIARY: THIS GRANT WILL PROVIDE FEDERAL FUNDING FOR AIRPORTS ASSOCIATED WITH KILLEEN, TEXAS.

RESIDENTIAL (SHELTER AND/OR TRANSITIONAL FOSTER CARE) SERVICES FOR UNACCOMPANIED CHILDREN-LICENSED AND TEXAS-EXEMPT AND FLORIDA-DELICENSED ONLY

MECHANISMS OF P53 ACTIVATION DURING STRESS RESPONSE

GENETIC EPIDEMIOLOGY OF MELANOMA

IMPACT AID SCHOOL CONSTRUCTION FORMULA GRANTS RECOVERY ACT

IMPROVE EXISTING AIRPORT

TCCU CARES RELIEF FUNDING

FTA TRANSFER FROM FDOT

SGR - FY 2012 STATE OF GOOD REPAIR

PURPOSE: IMPROVE/MODIFY/REHABILITATE TERMINAL BUILDING. ACTIVITIES TO BE PERFORMED/EXPECTED OUTCOMES: THIS PROJECT REHABILITATES THE EXISTING TERMINAL BUILDING TERMINAL LIGHTING BY REPLACING IT WITH MORE ENERGY EFFICIENT LIGHTS AND INSTALLING A SOLAR CANOPY OVER THE EXISTING PARKING/PEDESTRIAN WALKWAY TO REDUCE THE AIRPORTS OVERALL ELECTRICAL CONSUMPTION. INTENDED BENEFICIARY: THIS GRANT WILL PROVIDE FEDERAL FUNDING FOR AIRPORTS ASSOCIATED WITH KILLEEN, TEXAS.

IMPROVE EXISTING AIRPORT

USING RADIOGENOMICS TO NONINVASIVELY PREDICT THE MALIGNANT POTENTIAL OF INTRADUCTAL PAPILLARY MUCINOUS NEOPLASMS OF THE PANCREAS AND UNCOVER HIDDEN BIOLOGY

PURPOSE: REHABILITATE RUNWAY. ACTIVITIES TO BE PERFORMED/EXPECTED OUTCOMES: THIS PROJECT REHABILITATES 5,500 FEET OF EXISTING PAVED RUNWAY 17/35 TO MAINTAIN THE STRUCTURAL INTEGRITY AND MINIMIZE FOREIGN OBJECT DEBRIS TO EXTEND ITS USEFUL LIFE. THIS GRANT FUNDS THE FINAL PHASE, WHICH CONSISTS OF CONSTRUCTION. INTENDED BENEFICIARY: THIS GRANT WILL PROVIDE FEDERAL FUNDING FOR AIRPORTS ASSOCIATED WITH LEESBURG, VIRGINIA.

CITY OF LEESVILLE & FORT JOHNSON - LEESVILLE AIRPORT RUNWAY EXTENSION

AIAN HEAD START AND AIAN EARLY HEAD START

PURPOSE: REHABILITATE RUNWAY LIGHTING; REHABILITATE RUNWAY. ACTIVITIES TO BE PERFORMED/EXPECTED OUTCOMES: THIS PROJECT REHABILITATES 12,000 FEET OF EXISTING PAVED RUNWAY 6/24 TO MAINTAIN THE STRUCTURAL INTEGRITY AND MINIMIZE FOREIGN OBJECT DEBRIS TO EXTEND ITS USEFUL LIFE. THIS PROJECT REHABILITATES EXISTING RUNWAY 6/24 LIGHTING TO EXTEND ITS USEFUL LIFE. THIS GRANT FUNDS PHASE 1, WHICH CONSISTS OF DESIGN. INTENDED BENEFICIARY: THIS GRANT WILL PROVIDE FEDERAL FUNDING FOR AIRPORTS ASSOCIATED WITH FORT MYERS, FLORIDA.

TAMPA BAY COMMUNITY CANCER NETWORK (TBCCN)

LEECH LAKE RES. BUSINESS COMM. - LAW ENFORCEMENT BASE CR1 DIST.

NATIONAL HEMOPHILIA FOUNDATION PROPOSAL TO PREVENT COMPLICATIONS OF BLEEDING DISO

PURPOSE: CONSTRUCT APRON. THIS GRANT INCLUDES FUNDING BY THE AMERICAN RESCUE PLAN ACT OF 2021 TO INCREASE THE FEDERAL SHARE TO 100 PERCENT FOR THE AIRPORT IMPROVEMENT PROGRAM (AIP). ACTIVITIES TO BE PERFORMED/EXPECTED OUTCOMES: THIS PROJECT CONSTRUCTS A 20,000 SQUARE YARD APRON AT THE NORTH END OF THE AIRFIELD TO PROVIDE AIRCRAFT PARKING FOR USERS OF THE AIRPORT. THIS GRANT FUNDS THE FINAL PHASE, WHICH CONSISTS OF CONSTRUCTION. INTENDED BENEFICIARY: THIS GRANT WILL PROVIDE FEDERAL FUNDING FOR AIRPORTS ASSOCIATED WITH LEESBURG, VIRGINIA.

FY 2010 USC 5307 URBANIZED AREA FOR

FY 2012 USC 5307 URBANIZED AREA FORMULA

FY 2012 USC 5307 URBANIZED AREA FOR

COMMUNITY DEVELOPMENT BLOCK GRANTS/ENTITLEMENT GRANTS

IMPROVE EXISTING AIRPORT

FY 2011 USC 5307 URBANIZED AREA FOR

MAGNET SCHOOLS ASSISTANCE

DOMESTIC WATER GRANTS - 09/10 MULTI-YEAR STIMULUS

PURPOSE: REHABILITATE TAXIWAY. THIS GRANT IS FUNDED BY THE AMERICAN RESCUE PLAN ACT OF 2021 TO INCREASE THE FEDERAL SHARE TO 100 PERCENT FOR THE AIRPORT IMPROVEMENT PROGRAM (AIP). ACTIVITIES TO BE PERFORMED/EXPECTED OUTCOMES: THIS PROJECT REHABILITATES 11,320 FEET OF THE EXISTING TAXIWAY B PAVEMENT TO EXTEND ITS USEFUL LIFE. THIS GRANT FUNDS THE SECOND PHASE, WHICH CONSISTS OF REHABILITATION OF 3,610 FEET OF TAXIWAY B. INTENDED BENEFICIARY: THIS GRANT WILL PROVIDE FEDERAL FUNDING FOR AIRPORTS ASSOCIATED WITH KILLEEN, TEXAS.

STAFFING FOR ADEQUATE FIRE AND EMERGENCY RESPONSE (SAFER)

FY 2008 USC 5307 URBANIZED AREA FOR

IMPROVE EXISTING AIRPORT

PURPOSE: AMERICAN RESCUE PLAN ACT AWARDED AS ECONOMIC ASSISTANCE TO ELIGIBLE U.S. AIRPORTS AND ELIGIBLE CONCESSIONS AT THOSE AIRPORTS TO PREVENT, PREPARE FOR, AND RESPOND TO THE COVID-19 PANDEMIC. ACTIVITIES TO BE PERFORMED/EXPECTED OUTCOMES: THIS GRANT PROVIDES ECONOMIC RELIEF FROM RENT AND MINIMUM ANNUAL GUARANTEES TO SMALL AIRPORT CONCESSIONS LOCATED AT PRIMARY AIRPORTS. THIS GRANT PROVIDES ECONOMIC RELIEF FROM RENT AND MINIMUM ANNUAL GUARANTEES TO LARGE AIRPORT CONCESSIONS LOCATED AT PRIMARY AIRPORTS. INTENDED BENEFICIARY: THIS GRANT WILL PROVIDE FEDERAL FUNDING FOR AIRPORTS ASSOCIATED WITH FORT MYERS, FLORIDA.

EPIDEMIOLOGY AND BIOLOGY OF LNCRNAS IN OVARIAN CANCER

PURPOSE: CONSTRUCT BUILDING. ACTIVITIES TO BE PERFORMED/EXPECTED OUTCOMES: THIS PROJECT CONSTRUCTS A NEW 10,000 SQUARE FOOT HANGAR BUILDING TO ASSIST THE AIRPORT TO BE AS SELF-SUSTAINING AS POSSIBLE BY GENERATING REVENUE. THE SPONSOR HAS ADEQUATELY FINANCED THE AIRSIDE NEEDS OF THE AIRPORT. THIS GRANT FUNDS THE FINAL PHASE, WHICH CONSISTS OF CONSTRUCTION. INTENDED BENEFICIARY: THIS GRANT WILL PROVIDE FEDERAL FUNDING FOR AIRPORTS ASSOCIATED WITH KILLEEN, TEXAS.

WATER ONLY FACILITY GRANTS (MANDATORY FARM BILL)

PURPOSE: CONSTRUCT TAXILANE. ACTIVITIES TO BE PERFORMED/EXPECTED OUTCOMES: THIS PROJECT CONSTRUCTS A 3,700 FOOT TAXILANE TO CONNECT NEW HANGARS TO THE AIRFIELD. THIS GRANT FUNDS THE FIRST PHASE, WHICH CONSISTS OF CONSTRUCTION OF 850 FEET OF TAXILANE PAVEMENT. INTENDED BENEFICIARY: THIS GRANT WILL PROVIDE FEDERAL FUNDING FOR AIRPORTS ASSOCIATED WITH FORT MYERS, FLORIDA.

EARLY HEAD START/CHILD CARE PARTNERSHIP

LURLEEN B. WALLACE COMMUNITY COLLEGE CARES ACT FUNDING

LEECH LAKE RESERVATION BUSINESS COMMITTEE INC.

ELEMENTARY BUILDING FOR GRADES 3-6.

INDIAN HSG BLOCK GR

EARLY HEAD START - CHILD CARE PARTNERSHIP REQUEST FOR SUPPLEMENTAL FUNDING-COLA

SOUTHEAST REGION CASE-CONTROL STUDY OF ADULT GLIOMA

DOMESTIC WATER GRANTS - REGULAR

HISPANIC-SERVING INSTITUTIONS PROGRAM (STEM)

PURPOSE: SHIFT TAXIWAY. ACTIVITIES TO BE PERFORMED/EXPECTED OUTCOMES: THIS PROJECT SHIFTS EXISTING PAVED TAXIWAY E BY 1,040 FEET TO BRING THE AIRPORT INTO CONFORMITY WITH CURRENT STANDARDS. THE GRANT WILL FUND A PORTION OF PHASE 2, WHICH CONSISTS OF CONSTRUCTION. THIS GRANT IS ASSOCIATED WITH AN AIRPORT IMPROVEMENT PROGRAM GRANT THAT FUNDS THE REMAINING ELIGIBLE PORTION OF THE PROJECT. INTENDED BENEFICIARY: THIS GRANT WILL PROVIDE FEDERAL FUNDING FOR AIRPORTS ASSOCIATED WITH KILLEEN, TEXAS.

CORRECTIONS AND CORRECTIONAL ALTERNATIVES

AMERICAN INDIAN TRIBALLY CONTROLLED COLLEGES AND UNIVERSITIES

PURPOSE: IMPROVE/MODIFY/REHABILITATE TERMINAL BUILDING. THIS GRANT INCLUDES FUNDING BY THE AMERICAN RESCUE PLAN ACT OF 2021 TO INCREASE THE FEDERAL SHARE TO 100 PERCENT FOR THE AIRPORT IMPROVEMENT PROGRAM (AIP). ACTIVITIES TO BE PERFORMED/EXPECTED OUTCOMES: THIS PROJECT REHABILITATES THE EXISTING TERMINAL HEATING, VENTILATION AND AIR CONDITIONING SYSTEMS THAT HAVE REACHED THE END OF THEIR USEFUL LIVES. INTENDED BENEFICIARY: THIS GRANT WILL PROVIDE FEDERAL FUNDING FOR AIRPORTS ASSOCIATED WITH KILLEEN, TEXAS.

DEVELOPING INFORMATION INFRASTRUCTURE FOCUSED ON CANCER COMPARATIVE EFFECTIVENESS

HEAD START AND EARLY HEAD START

IMPROVE EXISTING AIRPORT

IMPROVE EXISTING AIRPORT

APPLICATION PURPOSE: THE GOAL OF THIS PROJECT IS TO PURCHASE TWO (2) BATTERY ELECTRIC BUSES PURCHASE TWO (2) CHARGING STATIONS AND CONSTRUCT THE INSTALLATION OF THE TWO (2) CHARGING STATIONS AT THE LEETRAN HEADQUARTERS FACILITY.; ACTIVITIES PERFORMED: THIS PROJECT WILL PROVIDE FOR THE REPLACEMENT OF DIESEL FUELED BUSES THROUGH THE PROCUREMENT OF REPLACEMENT BATTERY ELECTRIC BUSES RELATED CHARGING EQUIPMENT AND INFRASTRUCTURE IMPROVEMENTS STAFF TRAINING TO BEGIN LEE COUNTY TRANSITS ZERO-EMISSION TRANSITION PLAN.; EXPECTED OUTCOMES: THE PURCHASE OF ELECTRIC BUSES PROVIDES FOR A CLEAN QUIET AND MODERN VEHICLE FOR TRANSPORTATION SERVICES WHILE ELIMINATING THE HARMFUL EMISSIONS CREATED BY TRADITIONAL FOSSIL FUELED BUSES AND THE NOISE CREATED BY TRADITIONAL BUSES. THE PROJECT WILL RESULT IN REDUCED ENERGY CONSUMPTION AND THE HARMFUL EMISSIONS PRODUCED BY DIESEL FUELED BUSES.; INTENDED BENEFICIARIES: THIS PROJECT WILL BENEFIT TRANSIT USERS ALONG TWO ROUTES: ROUTE 10 AND ROUTE 140. THESE ROUTES WILL PROVIDE ENHANCED TRANSPORTATION AND MOBILITY FOR CENSUS TRACTS WITH HISTORICALLY DISADVANTAGED POPULATIONS.; SUBRECIPIENT ACTIVITIES: N/A

A FEDERATED GALAXY FOR USER-FRIENDLY LARGE-SCALE CANCER GENOMICS RESEARCH

INITIATION AND EVOLUTION OF THE OVARIAN CANCER MICROENVIRONMENT

LEECH LAKE - TPA BASE CR 1 DISTRIBUTION

HIV GENOMIC AGING PROJECT IN ONCOLOGY (HIV-GAP) - ABSTRACT. PEOPLE WITH HIV (PWH) EXPERIENCE HIGHER CANCER MORTALITY AND INCREASED LIKELIHOOD OF CANCER RELAPSE AFTER INITIAL THERAPY COMPARED TO HIV-UNINFECTED CANCER PATIENTS. OUR PRIOR WORK DEMONSTRATED THAT THESE HIV-ASSOCIATED CANCER OUTCOME DISPARITIES PERSIST AFTER ACCOUNTING FOR KNOWN RISK FACTORS. A NOVEL APPROACH TO IDENTIFY TARGETABLE DRIVERS OF THE POOR CANCER OUTCOMES EXPERIENCED BY PWH IS URGENTLY NEEDED TO IMPROVE PROGNOSIS. WE POSIT THAT CANCER OUTCOMES IN PWH ARE NEGATIVELY IMPACTED BY PROLONGED IMMUNE DYSFUNCTION THAT RESULTS IN ACCELERATED BIOLOGICAL AGING. BIOLOGICAL AGING CAN BE QUANTIFIED USING GENOMIC BIOMARKERS, SUCH AS DNA METHYLATION TRANSLATED INTO EPIGENETIC CLOCKS AND PRESENCE OF AGE-RELATED CLONAL HEMATOPOIESIS (ARCH). THE OVERARCHING GOAL OF THIS PROPOSAL IS TO COMPARE BIOLOGICAL AGE, MEASURED USING GENOMIC BIOMARKERS, BETWEEN CANCER PATIENTS WITH VERSUS WITHOUT HIV AND TO QUANTIFY ASSOCIATIONS BETWEEN MEASURED BIOLOGICAL AGE WITH IMPORTANT CLINICAL OUTCOMES. PREVIOUS STUDIES IN PWH (WITHOUT CANCER) INDICATE THAT HIV-INFECTED INDIVIDUALS HAVE HIGHER BIOLOGICAL AGE, CALCULATED USING BLOOD-BASED EPIGENETIC CLOCKS, COMPARED TO THEIR CHRONOLOGICAL AGE. THIS ACCELERATED AGING WAS ASSOCIATED WITH INCREASED MORTALITY. ARCH HAS ALSO BEEN REPORTEDLY INCREASED IN PWH. ARCH IS CHARACTERIZED BY ACQUIRED MUTATIONS THAT EXPAND OVER TIME IN BLOOD CELLS. ACCUMULATION OF THESE MUTATIONS IS LINKED TO INCREASED INFLAMMATION AND ADVERSE OUTCOMES. DATA SUGGEST THAT ARCH MAY BE TWICE AS PREVALENT IN PWH (WITHOUT CANCER) COMPARED TO HIV-UNINFECTED PERSONS. THUS, THERE IS EVIDENCE FOR A LINK BETWEEN HIV AND ADVANCED GENOMIC AGING IN PWH (WITHOUT CANCER), WHICH WARRANTS EXPLORATION IN THE CONTEXT OF CANCER. TO PRELIMINARILY EXPLORE OUR HYPOTHESIS, WE SEQUENCED BLOOD DNA FROM 30 SOLID TUMOR PATIENTS (15 PWH AND 15 HIV-UNINFECTED) MATCHED ON CHRONOLOGICAL AGE. OUR PRELIMINARY DATA INDICATE THAT GENOMIC AGING IS MORE ADVANCED IN CANCER PATIENTS WITH HIV. WE OBSERVED SIGNIFICANTLY HIGHER EPIGENETIC-BASED BIOLOGICAL AGE IN THE PWH. WE DETECTED ARCH MUTATIONS IN 3 PWH BUT 0 HIV-UNINFECTED PATIENTS. THE MEDIAN SURVIVAL IN PWH WAS ONLY 2 YEARS, COMPARED TO 9 YEARS IN HIV-UNINFECTED PATIENTS; MOST STRIKING WAS THE <1-YEAR MEDIAN SURVIVAL IN THE PWH WITH ARCH. IN THIS PROPOSAL, WE WILL UTILIZE AN ESTABLISHED PROTOCOL AT MOFFITT CANCER CENTER AND HUNTSMAN CANCER INSTITUTE TO PROSPECTIVELY COLLECT BIOSPECIMENS FROM 400 CANCER PATIENTS (200 WITH AND 200 WITHOUT HIV). THE INVESTIGATION IS TIMELY AND COMPELLING GIVEN THAT CANCER IS NOW A LEADING CAUSE OF DEATH IN PWH, AND INCIDENCE IS INCREASING. WE PROPOSE THE FOLLOWING AIMS: 1) COMPARE THE BIOLOGICAL AGE OF CANCER PATIENTS WITH VERSUS WITHOUT HIV USING EPIGENETIC CLOCKS; 2) COMPARE BASELINE PREVALENCE AND THERAPY-RELATED EVOLUTION OF ARCH BETWEEN CANCER PATIENTS WITH AND WITHOUT HIV; AND 3) QUANTIFY THE ASSOCIATION BETWEEN GENOMIC BIOMARKERS OF AGING AND CLINICAL OUTCOMES, INCLUDING AGING-RELATED FUNCTIONAL ASSESSMENTS. THIS STUDY WILL ADDRESS THE CRITICAL KNOWLEDGE GAP OF WHETHER CANCER PATIENTS WITH HIV ARE BIOLOGICALLY OLDER THAN AGE- MATCHED CANCER PATIENTS WITHOUT HIV, AND WHETHER THIS ADVANCED AGING CONTRIBUTES TO POOR CANCER OUTCOMES.

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NEUROCOGNITIVE AND PATIENT-REPORTED OUTCOMES AFTER CHIMERIC ANTIGEN RECEPTOR T-CELL THERAPY: A CONTROLLED COMPARISON - PROJECT SUMMARY THERE IS WIDESPREAD EXCITEMENT ABOUT CHIMERIC ANTIGEN RECEPTOR (CAR) T-CELL THERAPY, WHICH CAUSES COMPLETE DISEASE RESPONSE IN 40%-54% OF ADULTS WITH RELAPSED/REFRACTORY LARGE B-CELL LYMPHOMA (LBCL), COMPARED TO A RESPONSE RATE OF 7% TO CHEMOTHERAPY PRIOR TO THE ADVENT OF CAR T-CELL THERAPY. FOR THE FIRST TIME, LONG-TERM DISEASE-FREE SURVIVAL IS POSSIBLE FOR PATIENTS WITH ADVANCED LBCL. CAR T-CELL THERAPY CAUSES A UNIQUE PROFILE OF ADVERSE EVENTS, INCLUDING CYTOKINE RELEASE SYNDROME (CRS) AND NEUROLOGIC EVENTS, WHICH MAY BE RISK FACTORS FOR CANCER-ASSOCIATED COGNITIVE DECLINE (CACD). HOWEVER, LITTLE IS KNOWN ABOUT NEUROCOGNITION AND PATIENT- REPORTED OUTCOMES (PROS; E.G., SYMPTOMS, QUALITY OF LIFE OR QOL) IN CAR T-CELL THERAPY PATIENTS. THE GOAL OF THE CURRENT STUDY IS TO INVESTIGATE LONGITUDINAL CHANGES IN PROS AND CACD, OUTCOMES THAT ARE HIGHLY RELEVANT TO SURVIVORSHIP, IN THE FIRST YEAR AFTER CAR T-CELL THERAPY. WE WILL RECRUIT 204 LBCL PATIENTS TREATED WITH CAR T-CELL THERAPY AND 102 AGE-, SEX-, AND EDUCATION-MATCHED INDIVIDUALS WITHOUT CANCER. PARTICIPANTS WILL BE ASSESSED AT PRE-CAR T-CELL THERAPY BASELINE AND 3 AND 12 MONTHS LATER TO CAPTURE ACUTE AND LONGER-TERM OUTCOMES. AT EACH TIME POINT, PARTICIPANTS WILL COMPLETE INTERNET-BASED NEUROPSYCHOLOGICAL TESTING, VALIDATED PRO QUESTIONNAIRES, AND 7-DAY SMARTPHONE-BASED ECOLOGICAL MOMENTARY ASSESSMENT (EMA) OF COGNITION AND SELF-REPORTED RISK FACTORS FOR CACD (I.E., FATIGUE, DEPRESSION, PAIN, STRESS). ACTIGRAPHY DURING EMA PERIODS WILL BE USED TO OBJECTIVELY MEASURE SLEEP, PHYSICAL ACTIVITY, AND SEDENTARY BEHAVIOR AS BEHAVIORAL FACTORS FOR QOL AND CACD. BLOOD WILL BE COLLECTED AND BANKED AT EACH ASSESSMENT FOR FUTURE EXAMINATION OF BIOLOGICAL MECHANISMS (E.G., INFLAMMATION, ACCELERATED CELLULAR AGING). DATA WILL BE USED TO ADDRESS THE FOLLOWING AIMS: 1) TO EXAMINE BASELINE DIFFERENCES AND LONGITUDINAL CHANGES IN PATIENT-REPORTED OUTCOMES AND COGNITION IN CAR T-CELL THERAPY RECIPIENTS AND CONTROLS, 2) TO IDENTIFY DEMOGRAPHIC, CONTEXTUAL, AND CLINICAL RISK FACTORS THAT ARE ASSOCIATED WITH WORSE COGNITION IN CAR T-CELL THERAPY RECIPIENTS COMPARED TO CONTROLS, AND 3) TO DETERMINE BEHAVIORAL PROTECTIVE FACTORS ASSOCIATED WITH BETTER COGNITION AMONG CAR T-CELL THERAPY RECIPIENTS AND CONTROLS. THIS RESEARCH WILL BE HIGHLY IMPACTFUL, PROVIDING THE DATA NEEDED TO EDUCATE PATIENTS AND THEIR FAMILIES ABOUT CAR T-CELL THERAPY IN COLLABORATION WITH THE LEUKEMIA AND LYMPHOMA SOCIETY. ANALYSES FOCUSED ON RISK AND PROTECTIVE FACTORS WILL PROVIDE INSIGHTS INTO POTENTIAL TARGETS OF INTERVENTION TO IMPROVE QOL AND CACD IN THIS NOVEL CANCER SURVIVOR POPULATION.

HOME INVESTMENT PARTNERSHIPS PROGRAM

LEECH LAKE - TPA BASE CR1 DISTRIBUTION

LEECH LAKE RESERVATION BUSINESS COMMITTEE

ADVANCING CLINICAL TRIALS: WORKING THROUGH OUTREACH, NAVIGATION AND DIGITAL ENABLED REFERRAL AND RECRUITMENT STRATEGIES (ACT WONDERS) - ABSTRACT LIMITED PARTICIPATION OF RACIAL/ETHNIC MINORITIES IN THERAPEUTIC CLINICAL TRIALS PERPETUATES CANCER CARE DISPARITIES. NOT ONLY DO RACIAL/ETHNIC MINORITY PATIENTS HAVE LIMITED ACCESS TO STATE-OF-THE ART CARE OFFERED THROUGH A CLINICAL TRIAL, BUT THE SMALL NUMBERS OF RACIAL/ETHNIC MINORITY PARTICIPANTS REDUCES THE GENERALIZABILITY OF FINDINGS, THEREBY LIMITING THE CLINICAL USE OF NEW TREATMENTS. THE VAST MAJORITY OF RACIAL/ETHNIC MINORITIES RECEIVE THEIR CARE IN COMMUNITY SETTINGS WITH COMMUNITY PHYSICIANS. INCREASING RACIAL/ETHNIC MINORITY REFERRAL AND ENROLLMENT IN CLINICAL TRIALS REQUIRES CONSIDERATION OF MULTIPLE LEVELS OF INFLUENCE. COMMUNITY PATIENTS, COMMUNITY PHYSICIANS, AND CANCER CENTER PHYSICIANS ALL FACE BARRIERS TO REFERRAL AND ENROLLMENT OF RACIAL/ETHNIC MINORITIES TO CLINICAL TRIALS INCLUDING: KNOWLEDGE, ATTITUDES, TRUST, AND LOGISTICS. TO ADDRESS THESE CHALLENGES, WE HAVE DESIGNED ADVANCING CLINICAL TRIALS: WORKING THROUGH OUTREACH VIA NAVIGATION AND DIGITAL ENABLED REFERRAL AND RECRUITMENT STRATEGIES (ACT WONDER2S), DRIVEN BY LONGSTANDING COMMUNITY PARTNERSHIPS TO ADDRESS THE NEEDS OF MEDICALLY UNDERSERVED POPULATIONS, RESEARCH TO ADDRESS RACIAL/ETHNIC MINORITY ACCRUAL TO TRIALS, AND A HIGHLY INTEGRATED DIGITALLY DRIVEN APPROACH TO PRECISION CANCER CARE AND CLINICAL TRIALS. OUR MULTILEVEL INTERVENTION INCLUDES STRATEGIES THAT ARE DELIVERED VIA A COMMUNITY HEALTH EDUCATOR (CHE) AND/OR THROUGH DIGITAL APPROACHES FOR THE COMMUNITY PATIENT (EDUCATION, PATIENT PORTAL, CHE SUPPORT), COMMUNITY PHYSICIAN (EDUCATION, TRIAL CONNECT PORTAL, CANCER CENTER PHYSICIAN ENGAGEMENT, AND CHE SUPPORT), AND CANCER CENTER PHYSICIAN (EDUCATION, TRIAL CONNECT PORTAL, CHE SUPPORT, RECRUITMENT DASHBOARD). ACT WONDER2S WILL BE IMPLEMENTED IN IDENTIFIED PRIORITY ZONES WITHIN THE CATCHMENT AREA OF MOFFITT CANCER CENTER THAT HAVE A HIGHER CANCER BURDEN AMONG BLACK AND/OR HISPANIC POPULATIONS. OUR PRIMARY OUTCOME IS MINORITY ENROLLMENT TO NCI- SPONSORED THERAPEUTIC CLINICAL TRIALS AMONG BLACK AND HISPANIC PATIENTS WITH CANCER IN THE TWO-YEAR PERIOD FOLLOWING INTERVENTION. IN A THREE-PHASE APPROACH BASED ON LEARNER VERIFICATION AND USER-CENTERED DESIGN, WE AIM TO: 1) REFINE AND FINALIZE THE ACT WONDER2S INTERVENTION COMPONENTS BY CONDUCTING INTERVIEWS ASSESSING PREFERENCES FOR THE DESIGN AND FUNCTIONALITY OF THE CHE-LED AND DIGITALLY DRIVEN INTERVENTIONS; 2) IMPLEMENT AND EVALUATE THE IMPACT OF ACT WONDER2S ON RACIAL/ETHNIC MINORITY PATIENT REFERRAL AND ENROLLMENT ON NCI-SPONSORED CANCER TREATMENT TRIALS USING A HISTORICAL CONTROL DESIGN; 3) ASSESS IMPLEMENTATION OUTCOMES AND IDENTIFY BARRIERS AND FACILITATORS TO ACT WONDER2S. THIS INNOVATIVE INTERVENTION IS UNIQUE IN ITS MULTILEVEL SYSTEMS APPROACH THAT UTILIZES DIGITAL TOOLS ACCESSIBLE TO COMMUNITY PATIENTS, COMMUNITY PHYSICIANS, AND CANCER CENTER PHYSICIANS, WHICH IS COUPLED WITH SUPPORT FROM CHES FOR EACH OF THESE STAKEHOLDERS. OUR USE OF GEOSPATIAL ANALYTICS TO IDENTIFY PRIORITY ZONES IS A UNIQUE STRENGTH, ALONG WITH METHODOLOGICAL INNOVATIONS THAT WILL INTEGRATE LEARNER VERIFICATION, USER CENTERED DESIGN, AND IMPLEMENTATION SCIENCE TO REFINE INTERVENTION COMPONENTS AND MAKE ACT WONDER2S A SUCCESS.

CARES-REACH (COLORECTAL CANCER AWARENESS, RESEARCH, EDUCATION AND SCREENING-RURAL EXPANSION, ACCESS AND CAPACITY FOR HEALTH)

HEAD START

SMOKING CESSATION SELF-HELP FOR DUAL USERS OF TOBACCO CIGARETTES AND E-CIGARETTES

PURPOSE: REHABILITATE APRON. ACTIVITIES TO BE PERFORMED/EXPECTED OUTCOMES: THIS PROJECT REHABILITATES 46,000 SQUARE YARDS OF THE EXISTING SOUTH TERMINAL APRON TO MAINTAIN THE STRUCTURAL INTEGRITY OF THE PAVEMENT. . THIS GRANT FUNDS THE FINAL PHASE, WHICH CONSISTS OF CONSTRUCTION. INTENDED BENEFICIARY: THIS GRANT WILL PROVIDE FEDERAL FUNDING FOR AIRPORTS ASSOCIATED WITH LEESBURG, VIRGINIA.

THIS EDA FY23 DISASTER SUPPLEMENTAL ECONOMIC ADJUSTMENT ASSISTANCE AWARD TO THE LEECH LAKE BAND OF OJIBWE WILL HELP THE BAND DESIGN, CONSTRUCT, AND EQUIP A NEW WILD RICE PROCESSING FACILITY. AS A MAJOR WILD RICE HARVESTER, TRIBAL LEADERS DETERMINED THAT RICE PROCESSING IS A PREFERRED ALTERNATIVE TO OUTSOURCING THE OPERATION. WITH OTHER TRIBAL GROUPS INTERESTED IN UTILIZING THE BAND?S RICE PROCESSING CAPACITY, THE NEW EDA-FUNDED FACILITY WILL BE A SOURCE OF JOBS NOT ONLY FROM PROCESSING THE BAND?S RICE, BUT OTHER BANDS? AS WELL. THE NEW EDA-FUNDED 5,000 SQUARE FOOT FACILITY WILL HAVE THE CAPACITY TO PROCESS 300,000 POUNDS OF RICE ANNUALLY, AND THE PROJECT IS EXPECTED TO CREATE 15 NEW JOBS.

DEVELOPMENT OF NEW CASEIN KINASE 1 INHIBITOR FOR THE TREATMENT OF BRAIN CANCERS

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INVESTIGATION OF ORAL HPV INFECTION NATURAL HISTORY AND BIOMARKERS OF PERSISTENT INFECTION: THE HIM STUDY

DEVELOPING CDK12 INHIBITORS TO OVERCOME THERAPY RESISTANCE IN HER2+ AND KRAS DRIVEN BREAST AND LUNG CANCERS - PROJECT SUMMARY ALTHOUGH THE DEVELOPMENT OF TARGETED THERAPIES HAS IMPROVED OVERALL CANCER PATIENT SURVIVAL, ADAPTIVE RESPONSES BY TUMOR CELLS CAN RENDER THESE TREATMENTS INEFFECTIVE. THE DEVELOPMENT OF AGENTS THAT BLOCK ADAPTIVE RESPONSES, THEREBY INCREASING TREATMENT DURABILITY IS DESPERATELY NEEDED. WE AND OTHERS HAVE DEMONSTRATED THAT INHIBITORS OF THE TRANSCRIPTIONAL CYCLIN-DEPENDENT KINASES 12 (CDK12) AND 13 (CDK13) ARE STRONG CANDIDATES TO COMBAT ACQUIRED DRUG RESISTANCE. THE LONG-TERM GOAL OF THIS PROPOSAL IS TO DEVELOP A HIGHLY EFFECTIVE CDK12/13 INHIBITOR WITH AN AGGREGATE SET OF PROPERTIES SUITABLE TO ADVANCE AS A SAFETY ASSESSMENT CANDIDATE TO OVERCOME THERAPY RESISTANCE IN BOTH TNBC AND HER2+ BREAST CANCERS AND KRAS INHIBITOR-RESISTANT NSCLCS. THE OVERALL OBJECTIVE IN THIS APPLICATION IS TO IDENTIFY TARGETS AND PATHWAYS ALTERED BY TREATMENT-DIRECTED CDK12/13 REWIRING AND DEVELOP NEW THERAPEUTICS THAT RENDER THIS REWIRING - AN EXPLOITABLE VULNERABILITY. THE CENTRAL HYPOTHESIS IS THAT CDK12/13 ACTS AS A DRIVER OF TRANSCRIPTIONAL AND POST-TRANSCRIPTIONAL ADAPTATION AND THAT TARGETING CDK12/13 WILL BLOCK DRUG-INDUCED ESCAPE AND IMPROVE TREATMENT RESPONSE IN BREAST AND LUNG CANCER. THE RATIONALE FOR THIS PROJECT POSITS THAT: (I) MULTIPLE MALIGNANCIES HIJACK CDK12/13 TO PROVOKE TRANSCRIPTIONAL AND SIGNALING PLASTICITY AS AN ADAPTIVE STRESS RESISTANCE MECHANISM, AND (II) ELUCIDATION OF MECHANISMS UNDERPINNING COMPOUND ACTION WILL OFFER A STRONG SCIENTIFIC FRAMEWORK THAT WILL FACILITATE FUTURE CLINICAL DEVELOPMENT OF THESE NEW AGENTS FOR IMPROVED PATIENT OUTCOME. THE CENTRAL HYPOTHESIS WILL BE TESTED BY PURSUING THREE SPECIFIC AIMS: (1) OPTIMIZE THE DRUG-LIKE PROPERTIES OF IN-HOUSE CDK12/13 SPECIFIC INHIBITORS; (2) DEFINE AND VALIDATE THE MECHANISMS WHEREBY CDK12/13 INHIBITION PREVENTS OR REVERSES TREATMENT RESISTANCE IN TNBC AND HER2+ BREAST CANCERS (3) DEFINE AND VALIDATE THE MECHANISMS WHEREBY CDK12/13 INHIBITION PREVENTS OR REVERSES KRASG12C INHIBITOR RESISTANCE IN NSCLC. ACCORDINGLY, USING A BATTERY OF APPROACHES, WE WILL: A) OPTIMIZE KEY CDK12/13 INHIBITOR PARAMETERS TO DELIVER A SAFETY ASSESSMENT CANDIDATE; B) DEFINE AND VALIDATE THE TRANSCRIPTIONAL AND TRANSLATIONAL MECHANISMS, WHEREBY SR-4835 PROVOKES RESENSITIZATION TO CHEMOTHERAPY, AND C) VALIDATE CELL-BASED OBSERVATIONS IN PRE-CLINICAL XENOGRAFT MODELS. THE RESEARCH APPROACH OF OUR MULTI-PI APPLICATION IS INNOVATIVE, AS OUR TEAM HAS DEVELOPED EXCEPTIONALLY SELECTIVE AND NOVEL SMALL MOLECULE CDK12/13 IN VIVO ACTIVE MOLECULAR PROBES THAT WILL ENABLE (I) INTERROGATION OF THE ROLES OF CDK12/13 DURING ADAPTATION TO TREATMENT RESISTANCE (II) EVALUATION THAT DISRUPTING TRANSCRIPTIONAL CONTROL WILL COUNTER-RESISTANCE MECHANISMS PROVIDING LASTING, MORE DURABLE ANTI-CANCER RESPONSES OR EVEN CURES; AND (III) UNDERSTANDING OF THE CRITICAL SIGNALING NODES THAT DRIVE DRUG RESISTANCE. THE PROPOSED RESEARCH IS HIGHLY SIGNIFICANT AND PROVIDES A STRONG SCIENTIFIC RATIONALE FOR THE CONTINUED DEVELOPMENT OF NOVEL CDK12/13 INHIBITORS. WE SUBMIT THAT INSIGHT INTO THE MOLECULAR UNDERPINNINGS OF THE MASTER EFFECTORS OF CDK12 AND CDK13-DRIVEN SIGNALING, TOGETHER WITH AN OPTIMIZED CDK12/13 INHIBITOR WILL OFFER NEW OPPORTUNITIES FOR IMPROVED COMBINATION TREATMENTS FOR BREAST AND LUNG CANCER.

TARGETING SLC16A/MCT LACTATE TRANSPORTERS IN CANCER THERAPEUTICS

THERAPEUTIC TARGETING OF CASEIN KINASE-1-DELTA IN PRIMARY AND METASTATIC BREAST CANCER

IMPROVE EXISTING AIRPORT

2021 CCDF TRIBAL CONSTRUCTION

IMPROVE EXISTING AIRPORT CONSTRUCT NEW AIRPORT; CONSTRUCT NEW AIR

COMBINED RADIATION ACOUSTICS AND ULTRASOUND IMAGING FOR REAL-TIME GUIDANCE IN RADIOTHERAPY

IMPROVING PREDICTION OF CHEMOTHERAPY-INDUCED NAUSEA: INTEGRATING GENES, BEHAVIOR, AND THE MICROBIOME