The Pennsylvania State University

PENN STATE HIGHER EDUCATION EMERGENCY RELIEF FUND - INSTITUTION RELIEF

PENN STATE HIGHER EDUCATION EMERGENCY RELIEF FUND - STUDENT RELIEF

NEW AWARD TO PENN STATE UNIVERSITY FOR THE PROJECT TITLED, "GREATER PHILADELPHIA INNOVATION CLUSTER FOR ENERGY EFFICIENT BUILDINGS." TOGETHER WITH 2

TAS::89 0227::TAS RECOVERY; RECOVERY ACT - CENTER FOR LIGNOCELLULOSE STRUCTURE AND FORMATION -- EFRC; PI - DANIEL COSGROVE

INTERACTION OF IONIZING RADIATION WITH MATTER

MACRO: MODELS FOR ENABLING CONTINUOUS RECONFIGURABILITY OF SECURE MISSIONS - CYBER SECURITY (CS) COLLABORATIVE RESEARCH ALLIANCE (CRA)

PENN STATE CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTE

EXPANDS MARKETS FOR CLIMATE-SMART DAIRY IN PA AND SUPPORTS FARMER IMPLEMENTATION AND MONITORING OF CLIMATE-SMART PRACTICES THAT REDUCE GREENHOUSE-GAS EMISSIONS OR SEQUESTER CARBON.

NASA TO THE SCHOOLS THE PENNSYLVANIA STATE UNIVERSITY PROPOSES TO REINVENT NASA'SAEROSPACE EDUCATION

ASCENT SUPERSONIC COMMUNITY INSTRUMENTATION AND MONITORING

MIP: 2D CRYSTAL CONSORTIUM (MIP-2DCC)

MIP: 2D CRYSTAL CONSORTIUM (MIP-2DCC)

DATA COORDINATING CENTER FOR THE TYPE 1 DIABETES IN ACUTE PANCREATITIS CONSORTIUM

MRSEC: CENTER FOR NANOSCALE SCIENCE

UNDERSTANDING MULTISTRESSOR AND MULTISCALE DRIVERS OF FEEDBACKS, CASCADING FAILURES, AND RISK MANAGEMENT PATHWAYSWITHIN COMPLEX MSD SYSTEMS

MRSEC: CENTER FOR NANOSCALE SCIENCE

UNIVERSITY TRANSPORTATION CENTERS

CENTER FOR 3D FERROELECTRIC MICROELECTRONICS

UNIVERSITY COALITION FOR FOSSIL ENERGY RESEARCH

FEED THE FUTURE INNOVATION LAB FOR CURRENT AND EMERGING THREATS TO CROPS.

PENN STATE: ABSL-3 FACILITY CONSTRUCTION

AFTER 20 YEARS, THE UNITED STATES IS STARTING THE NEXT CHAPTER IN THE "FOREVER WARS" OF AFGHANISTAN AND IRAQ. BY THE END OF THE YEAR, ALL U.S. FORCES AND N.A.T.O. TROOPS WILL BE DEPARTING THE REGION, ALL EQUIPMENT WILL BE RETURNED TO THE UNITED STATES, AND WITHIN-COUNTRY INSTALLATIONS WILL BE RELINQUISHED TO THE AFGHANISTAN GOVERNMENT. DURING THIS "FOREVER WAR," THE DEMANDS HAVE BEEN ENORMOUS AND UNRELENTING FOR SERVICE MEMBERS AND THEIR FAMILIES. MOREOVER, SERVICE MEMBERS AND THEIR FAMILIES HAVE BEEN THE FRONTLINE OF SUPPORT AS THE UNITED STATES AND THE WORLD HAS ADDRESSED THE COVID-19 PANDEMIC.THE CLEARINGHOUSE FOR MILITARY FAMILY READINESS HAS BEEN LOCATED AT THE PENNSYLVANIA STATE UNIVERSITY (CLEARINGHOUSE) FOR THE LAST 11YEARS. THIS CONTINUATION FUNDING REPRESENTS THE NEXT PHASE OF WORK FOR THE CLEARINGHOUSE OPERATIONS, THE THRIVE PARENTING INITIATIVE, DEPARTMENT OF DEFENSE (DOD) FAMILY ADVOCACY PROGRAM (FAP) SUPPORT, FINALIZATION OF A VETTING SYSTEM FOR ONLINE RESOURCES, NAVY AND MARINE TAKE ROOT HOME VISITATION PILOT, AS WELL AS SEVERAL FAMILY ADVOCACY PROGRAM PROJECTS (QUALITY ASSURANCE OF INCIDENT DETERMINATION COMMITTEE PROCESS, PROBLEM SEXUAL BEHAVIOR IN CHILDREN AND YOUTH, STAFFING TOOL DEVELOPMENT).THE CLEARINGHOUSE IS AN APPLIED RESEARCH CENTER COMMITTED TO ADVANCING THE HEALTH AND WELL-BEING OF SERVICE MEMBERS, VETERANS, AND THEIR FAMILIES. THIS FOCUS IS ESSENTIAL AND PROMOTES FAMILY RESILIENCE, WHICH IS A SIGNIFICANT PREDICTOR OF MILITARY READINESS, THAT IS, THE ABILITY OF SERVICE MEMBERS TO EFFECTIVELY EXECUTE THEIR MISSIONS. FAMILY SATISFACTION WITH THE MILITARY IS THE STRONGEST PREDICTOR OF SERVICE MEMBER RETENTION. THUS, RESILIENT MILITARY FAMILIES ARE ESSENTIAL TO NATIONAL SECURITY, THE STABILITY OF THE ARMED FORCES, AND THE HEALTH AND WELL-BEING OF MILLIONS OF MILITARY CHILDREN. THE HEALTH AND WELL-BEING OF SERVICE MEMBERS AND THEIR FAMILIES.@FONT-FACE{PANOSE-1:2 4 5 3 5 4 6 3 2 4;MSO-FONT-CHARSET:0;MSO-GENERIC-MSO-FONT-PITCH:VARIABLE;MSO-FONT-SIGNATURE:-536870145 1107305727 0 0 415 0;}P.MSONORMAL, LI.MSONORMAL, DIV.MSONORMAL{MSO-STYLE-UNHIDE:NO;MSO-STYLE-QFORMAT:YES;MSO-STYLE-PARENT:"";MARGIN:0IN;MSO-PAGINATION:WIDOW-ORPHAN;;MSO-FAREAST-}.MSOCHPDEFAULT{MSO-STYLE-TYPE:EXPORT-ONLY;MSO-DEFAULT-PROPS:YES;;MSO-ANSI-;MSO-BIDI-;}DIV.WORDSECTION1{PAGE:WORDSECTION1;}

AMBULATORY METHODS FOR MEASURING COGNITIVE CHANGE

GRADUATE RESEARCH FELLOWSHIP PROGRAM (GRFP)

MRSEC: CENTER FOR NANOSCALE SCIENCE

CENTER FOR COMPLEX DATA TO KNOWLEDGE IN DRUG ABUSE AND HIV BEHAVIORAL SCIENCE

PENN STATE UNIVERSITY'S TRANSLATIONAL CENTER FOR CHILD MALTREATMENT STUDIES TCCMS

CENTER FOR PREVENTION AND TREATMENT METHODOLOGY

EVOLUTION OF A HABITABLE PLANET

BUS TESTING PROGRAM

PENN STATE TCORS: TOBACCO PRODUCT COMPOSITION EFFECTS ON TOXICITY AND ADDICTION - PROJECT SUMMARY / ABSTRACT: OVERALL THE OVERALL OBJECTIVE OF THE PENN STATE TCORS IS TO PROVIDE A SCIENCE BASE FOR FDA TO TAKE REGULATORY ACTIONS TO REDUCE THE HARM FROM TOBACCO PRODUCTS. OUR CENTER WILL ACCOMPLISH THIS THROUGH A COLLABORATION OF EXPERIENCED AND NEW TOBACCO REGULATORY SCIENTISTS FOCUSING ON STATE-OF-THE-ART BASIC AND TRANSLATIONAL RESEARCH ON THE TOXICITY AND ADDICTION OF DIVERSE TOBACCO PRODUCTS. THIS INCLUDES DEVELOPING NEW RESEARCH METHODS THAT HAVE THE POTENTIAL TO BE USED IN THE TOBACCO REGULATORY FIELD BEYOND THE SCOPE OF THE PENN STATE TCORS RESEARCH PROGRAM. WHILE TOXICITY IS A VERY BROAD SCIENTIFIC FIELD, OUR FOCUS WILL BE ON THE CHARACTERIZATION OF OXIDANTS IN TOBACCO SMOKE AND IN AEROSOLS, AND THEIR BIOLOGICAL EFFECTS IN PERSONS WHO USE TOBACCO PRODUCTS. WE WILL EXAMINE SEVERAL TOBACCO PRODUCTS INCLUDING E-CIGARETTES (EC), LITTLE CIGARS AND NICOTINE POUCHES. OVERALL, THESE STUDIES ARE A LOGICAL EXTENSION OF OUR PREVIOUS WORK ON OXIDANTS PRODUCED BY COMBUSTIBLE AND NON-COMBUSTIBLE TOBACCO PRODUCTS AND THE IMPACT OF PRODUCT DESIGN CHARACTERISTICS ON THEIR PRODUCTION. IN ADDITION, THEY STEM FROM OUR PREVIOUS RESEARCH ON THE FEASIBILITY OF A REDUCED NICOTINE STANDARD FOR CIGARETTES TO MINIMALLY-ADDICTING OR NONADDICTING LEVELS. THESE STUDIES INDICATED THAT SOME SMOKERS WILL CONTINUE TO USE LOWERED NICOTINE PRODUCTS AND THAT ADDITIONAL STRATEGIES ARE NEEDED TO REDUCE TOBACCO HARM INCLUDING PROVIDING SAFE ALTERNATIVE SOURCES OF NICOTINE TO ADDICTED SMOKERS AND DETERMINING WHICH TOBACCO PRODUCT CHARACTERISTICS ARE ASSOCIATED WITH GREATER HARM. THUS, THE OVERALL INTEGRATIVE THEME OF OUR CENTER IS TO BETTER UNDERSTAND HOW PRODUCT DESIGN CHARACTERISTICS OF DIVERSE AND ALTERNATIVE TOBACCO PRODUCTS AFFECT THEIR TOXICITY AND ADDICTIVENESS. OUR PROPOSED CENTER WILL ADDRESS SEVERAL CTP SCIENTIFIC DOMAINS INCLUDING TOXICITY, ADDICTION AND PRODUCT COMPOSITION AND DESIGN USING A HIGHLY INTERDISCIPLINARY AND INTEGRATIVE APPROACH. IN PROJECT 1, WE WILL CONDUCT TRANSLATIONAL STUDIES IN BOTH LABORATORY ANIMAL MODELS AND EC USERS TO ADDRESS THE HYPOTHESIS THAT INHALED EC OXIDANTS AND THEIR POTENTIAL FOR HARM ARE INFLUENCED BY PRODUCT DESIGN FEATURES AND THE BIOLOGICAL EFFECTS OF THESE OXIDANTS CAN BE MEASURED THROUGH BIOMARKERS OF BOTH EXPOSURE AND HARM. IN PROJECT 2, WE WILL INVESTIGATE THE POTENTIAL TOXICITY RELATED TO OXIDANT PRODUCTION IN LITTLE CIGAR SMOKERS AND DESIGN FEATURES THAT MAY AFFECT HUMAN EXPOSURE USING EPIDEMIOLOGIC DATA AND CLINICAL AND LABORATORY STUDIES. IN PROJECT 3, WE WILL FOCUS ON THE NICOTINE POUCH AS AN ALTERNATIVE TOBACCO PRODUCT BY CONDUCTING A RANDOMIZED CONTROLLED CLINICAL TRIAL TO TEST THAT HYPOTHESIS THAT BIOMARKERS OF HARM, INCLUDING THOSE RELATED TO OXIDATIVE STRESS, ARE SIGNIFICANTLY REDUCED IN SMOKERS WHO ARE PROVIDED HIGH NICOTINE POUCHES. THE PSTCORS WILL ALSO CONTINUE ITS STRONG SUPPORT OF CAREER DEVELOPMENT IN TOBACCO REGULATORY SCIENCE THROUGH AN INTEGRATED AND MULTIDISCIPLINARY SERIES OF EDUCATIONAL PROGRAMS AND RESEARCH SUPPORT THROUGH THE CAREER DEVELOPMENT CORE. FINALLY, IN SUPPORT OF ALL CENTER ACTIVITIES WILL BE A MATURE AND EXPERIENCED SYSTEM OF CORES: ADMINISTRATIVE CORE, BIOSTATISTICS AND DATA MANAGEMENT CORE AND BIOMARKER AND ANALYTICAL CHEMISTRY CORE.

WHAT ARE SUSTAINABLE CLIMATE-RISK MANAGEMENT STRATEGIES?

GRADUATE RESEARCH FELLOWSHIP PROGRAM (GRFP)

PURPOSE THE COLLEGE OF AGRICULTURAL SCIENCES AT PENN STATE WILL PROVIDE COMPREHENSIVE SUPPORT TO PENNSYLVANIA RESIDENTS THROUGH THE PENNSYLVANIA AGRICULTURAL EXPERIMENT STATION (AES) AND PENN STATE EXTENSION (PSE) ACTIVITIES. WE WILL BE RESPONSIVE TO STAKEHOLDER NEEDS THROUGH TRANSLATIONAL RESEARCH AND DELIVERY OF SCIENCE?BASED PROGRAMS TO CLIENTELE. WE WILL ALSO CONDUCT INTERNATIONALLY RELEVANT FUNDAMENTAL RESEARCH THAT GENERATES BASELINE DATA TO SOLVE FUTURE PROBLEMS AND ACTIVELY SEEK NEW AND BETTER WAYS TO COMMUNICATE OUR PROGRAMS TO NEW AUDIENCES. OUR FACULTY AND STAFF, SUPPORTED BY FEDERAL BASE FUNDING, WILL EFFECTIVELY LEVERAGE THIS INVESTMENT AGAINST MANY OTHER FUNDING SOURCES TO CONDUCT PROGRAMS OF THE HIGHEST CALIBER. WE ARE COMMITTED TO EXCELLENCE IN RESEARCH, EDUCATING THE NEXT GENERATION OF AGRICULTURAL PROFESSIONALS AND CITIZENS, AND PROMOTING LIFE?LONG LEARNING AMONG THE CITIZENS OF PENNSYLVANIA. OUR COLLEGE'S MISSION IS CLEAR: "THE MISSION OF THE COLLEGE OF AGRICULTURAL SCIENCES IS TO DISCOVER, INTEGRATE, TRANSLATE, AND DISSEMINATE KNOWLEDGE TO ENHANCE THE FOOD AND AGRICULTURAL SYSTEM, NATURAL RESOURCES AND ENVIRONMENTAL STEWARDSHIP, AND ECONOMIC AND SOCIAL WELL?BEING, THEREBY IMPROVING THE LIVES OF PEOPLE IN PENNSYLVANIA, THE NATION, AND THE WORLD." AGRICULTURE FACES CHALLENGES OF RISING ENERGY COSTS, WEATHER EXTREMES, AN EXPANDING HUMAN POPULATION, ENVIRONMENTAL DEGRADATION, LOSS OF BIODIVERSITY, AND LABOR SHORTAGES. THE COVID?19 PANDEMIC ADDED TO THE CHALLENGES: DISRUPTIONS TO FOOD CHAINS, WORKFORCE CHALLENGES, IMPACTS ON YOUTH EDUCATION, AND BUSINESS INTERRUPTIONS. WE MUST ADDRESS THESE ISSUES TO MITIGATE FUTURE WIDESPREAD DISRUPTIONS THAT IMPACT ALL OF SOCIETY. ACTIVITIES TO HELP MEET THESE CHALLENGES, WE ARE DEVELOPING A CONCEPTUAL FRAMEWORK BASED ON THE SCIENCE OF AGRICULTURAL SUSTAINABILITY??DEFINED AS THE INTEGRATION OF NATURAL AND SOCIAL SCIENCES TO INFORM PRACTICE AND POLICY FOR PRODUCTIVE, WORKING LANDSCAPES, HEALTHY WATERSHEDS, AND RESILIENT ECONOMIES. THIS INNOVATIVE APPROACH TO AGRICULTURAL RESEARCH, ENGAGEMENT, AND EDUCATION CENTERS ON THE IMPACTS AND SYNERGIES OF CONTIGUOUS RURAL AND URBAN LANDSCAPES. PENN STATE EXTENSION PROVIDES ACCESS TO FACE?TO?FACE AND ONLINE SCIENCE?BASED EDUCATION TO OUR CUSTOMERS TO HELP THEM ADDRESS PROBLEMS AND TAKE ADVANTAGE OF OPPORTUNITIES FOR IMPROVEMENT AND INNOVATION. WE MAKE A DIFFERENCE LOCALLY THROUGH FOCUSED ENGAGEMENT AND, MORE WIDELY, TO CUSTOMERS CONNECTING IN THE DIGITAL LANDSCAPE. INITIATIVES ENSURE THE STABILITY OF THE FOOD SYSTEM IN THE COMMONWEALTH AND OUR EFFORTS TO PROVIDE A BROAD?BASED ONLINE LEARNING PLATFORM FOR NONCREDIT PROGRAMMING AND DIGITAL EDUCATION. THE WORK OF AES AND PSE IN OUR COLLEGE IS BUILT ON THE THREE INTEGRATED PILLARS OF INTENSIFICATION, RESILIENCE, AND REGENERATION OF AGRICULTURAL LANDSCAPES AS SOLUTIONS TO SOME OF THE MOST VEXING PROBLEMS CONFRONTING PENNSYLVANIA AND SIMILAR MOSAIC LANDSCAPES WORLDWIDE. OUR CRITICAL ISSUES CAPTURE THE SYSTEMS APPROACH WE IDENTIFIED AS ESSENTIAL FOR GENERATING IMPACT. THEY CUT ACROSS DISCIPLINES, UNITING OUR RESEARCH EFFORTS WITH OUR EXTENSION EDUCATION CAPACITY. THIS INTERDISCIPLINARY PHILOSOPHY HAS REINFORCED THE NATURAL TENDENCY OF OUR FACULTY AND EXTENSION EDUCATORS TO WORK COOPERATIVELY TO SOLVE PROBLEMS. COUPLED WITH THE JOINT RESEARCH?EXTENSION APPOINTMENTS OF MANY OF OUR COLLEGE FACULTY, OUR WORK, AS REPRESENTED IN OUR PLAN OF WORK, WILL EFFECTIVELY UNITE FUNDAMENTAL KNOWLEDGE WITH PRACTICAL SOLUTIONS DELIVERED TO STAKEHOLDERS, EMPOWERING THEM TO ADDRESS IMPORTANT AND EMERGING ISSUES USING RELEVANT SCIENCE?BASED RESOURCES. THE NET RESULT WILL BE A TANGIBLE BENEFIT IN ECONOMIC PROSPERITY AND QUALITY OF LIFE FOR PENNSYLVANIA CITIZENS.

PURPOSE: THE COLLEGE OF AGRICULTURAL SCIENCES AT PENN STATE WILL PROVIDE COMPREHENSIVE SUPPORT TO PENNSYLVANIA RESIDENTS THROUGH THE PENNSYLVANIA AGRICULTURAL EXPERIMENT STATION (AES) AND PENN STATE EXTENSION (PSE) ACTIVITIES. WE WILL BE RESPONSIVE TO STAKEHOLDER NEEDS THROUGH TRANSLATIONAL RESEARCH AND DELIVERY OF SCIENCE BASED PROGRAMS TO CLIENTELE. WE WILL ALSO CONDUCT INTERNATIONALLY RELEVANT FUNDAMENTAL RESEARCH THAT GENERATES BASELINE DATA TO SOLVE FUTURE PROBLEMS AND ACTIVELY SEEK NEW AND BETTER WAYS TO COMMUNICATE OUR PROGRAMS TO NEW AUDIENCES. OUR FACULTY AND STAFF, SUPPORTED BY FEDERAL BASE FUNDING, WILL EFFECTIVELY LEVERAGE THIS INVESTMENT AGAINST MANY OTHER FUNDING SOURCES TO CONDUCT PROGRAMS OF THE HIGHEST CALIBER. WE ARE COMMITTED TO EXCELLENCE IN RESEARCH, EDUCATING THE NEXT GENERATION OF AGRICULTURAL PROFESSIONALS AND CITIZENS, AND PROMOTING LIFE LONG LEARNING AMONG THE CITIZENS OF PENNSYLVANIA. OUR COLLEGE'S MISSION IS CLEAR: THE MISSION OF THE COLLEGE OF AGRICULTURAL SCIENCES IS TO DISCOVER, INTEGRATE, TRANSLATE, AND DISSEMINATE KNOWLEDGE TO ENHANCE THE FOOD AND AGRICULTURAL SYSTEM, NATURAL RESOURCES AND ENVIRONMENTAL STEWARDSHIP, AND ECONOMIC AND SOCIAL WELLBEING, THEREBY IMPROVING THE LIVES OF PEOPLE IN PENNSYLVANIA, THE NATION, AND THE WORLD. AGRICULTURE FACES CHALLENGES OF RISING ENERGY COSTS, WEATHER EXTREMES, AN EXPANDING HUMAN POPULATION, ENVIRONMENTAL DEGRADATION, LOSS OF BIODIVERSITY, AND LABOR SHORTAGES. THE COVID19 PANDEMIC ADDED TO THE CHALLENGES: DISRUPTIONS TO FOOD CHAINS, WORKFORCE CHALLENGES, IMPACTS ON YOUTH EDUCATION, AND BUSINESS INTERRUPTIONS. WE MUST ADDRESS THESE ISSUES TO MITIGATE FUTURE WIDESPREAD DISRUPTIONS THAT IMPACT ALL OF SOCIETY. ACTIVITIES: TO HELP MEET THESE CHALLENGES, WE ARE DEVELOPING A CONCEPTUAL FRAMEWORK BASED ON THE SCIENCE OF AGRICULTURAL SUSTAINABILITY DEFINED AS THE INTEGRATION OF NATURAL AND SOCIAL SCIENCES TO INFORM PRACTICE AND POLICY FOR PRODUCTIVE, WORKING LANDSCAPES, HEALTHY WATERSHEDS, AND RESILIENT ECONOMIES. THIS INNOVATIVE APPROACH TO AGRICULTURAL RESEARCH, ENGAGEMENT, AND EDUCATION CENTERS ON THE IMPACTS AND SYNERGIES OF CONTIGUOUS RURAL AND URBAN LANDSCAPES. PENN STATE EXTENSION PROVIDES ACCESS TO FACE TO FACE AND ONLINE SCIENCE BASED EDUCATION TO OUR CUSTOMERS TO HELP THEM ADDRESS PROBLEMS AND TAKE ADVANTAGE OF OPPORTUNITIES FOR IMPROVEMENT AND INNOVATION. WE MAKE A DIFFERENCE LOCALLY THROUGH FOCUSED ENGAGEMENT AND, MORE WIDELY, TO CUSTOMERS CONNECTING IN THE DIGITAL LANDSCAPE. INITIATIVES ENSURE THE STABILITY OF THE FOOD SYSTEM IN THE COMMONWEALTH AND OUR EFFORTS TO PROVIDE A BROAD BASED ONLINE LEARNING PLATFORM FOR NONCREDIT PROGRAMMING AND DIGITAL EDUCATION. THE WORK OF AES AND PSE IN OUR COLLEGE IS BUILT ON THE THREE INTEGRATED PILLARS OF INTENSIFICATION, RESILIENCE, AND REGENERATION OF AGRICULTURAL LANDSCAPES AS SOLUTIONS TO SOME OF THE MOST VEXING PROBLEMS CONFRONTING PENNSYLVANIA AND SIMILAR MOSAIC LANDSCAPES WORLDWIDE. OUR CRITICAL ISSUES CAPTURE THE SYSTEMS APPROACH WE IDENTIFIED AS ESSENTIAL FOR GENERATING IMPACT. THEY CUT ACROSS DISCIPLINES, UNITING OUR RESEARCH EFFORTS WITH OUR EXTENSION EDUCATION CAPACITY. THIS INTERDISCIPLINARY PHILOSOPHY HAS REINFORCED THE NATURAL TENDENCY OF OUR FACULTY AND EXTENSION EDUCATORS TO WORK COOPERATIVELY TO SOLVE PROBLEMS. COUPLED WITH THE JOINT RESEARCH EXTENSION APPOINTMENTS OF MANY OF OUR COLLEGE FACULTY, OUR WORK, AS REPRESENTED IN OUR PLAN OF WORK, WILL EFFECTIVELY UNITE FUNDAMENTAL KNOWLEDGE WITH PRACTICAL SOLUTIONS DELIVERED TO STAKEHOLDERS, EMPOWERING THEM TO ADDRESS IMPORTANT AND EMERGING ISSUES USING RELEVANT SCIENCE BASED RESOURCES. THE NET RESULT WILL BE A TANGIBLE BENEFIT IN ECONOMIC PROSPERITY AND QUALITY OF LIFE FOR PENNSYLVANIA CITIZENS.

PURPOSE: THE COLLEGE OF AGRICULTURAL SCIENCES AT PENN STATE WILL PROVIDE COMPREHENSIVE SUPPORT TO PENNSYLVANIA RESIDENTS THROUGH THE PENNSYLVANIA AGRICULTURAL EXPERIMENT STATION (AES) AND PENN STATE EXTENSION (PSE) ACTIVITIES. WE WILL BE RESPONSIVE TO STAKEHOLDER NEEDS THROUGH TRANSLATIONAL RESEARCH AND DELIVERY OF SCIENCE?BASED PROGRAMS TO CLIENTELE. WE WILL ALSO CONDUCT INTERNATIONALLY RELEVANT FUNDAMENTAL RESEARCH THAT GENERATES BASELINE DATA TO SOLVE FUTURE PROBLEMS AND ACTIVELY SEEK NEW AND BETTER WAYS TO COMMUNICATE OUR PROGRAMS TO NEW AUDIENCES. OUR FACULTY AND STAFF, SUPPORTED BY FEDERAL BASE FUNDING, WILL EFFECTIVELY LEVERAGE THIS INVESTMENT AGAINST MANY OTHER FUNDING SOURCES TO CONDUCT PROGRAMS OF THE HIGHEST CALIBER. WE ARE COMMITTED TO EXCELLENCE IN RESEARCH, EDUCATING THE NEXT GENERATION OF AGRICULTURAL PROFESSIONALS AND CITIZENS, AND PROMOTING LIFE?LONG LEARNING AMONG THE CITIZENS OF PENNSYLVANIA. OUR COLLEGE'S MISSION IS CLEAR: 'THE MISSION OF THE COLLEGE OF AGRICULTURAL SCIENCES IS TO DISCOVER, INTEGRATE, TRANSLATE, AND DISSEMINATE KNOWLEDGE TO ENHANCE THE FOOD AND AGRICULTURAL SYSTEM, NATURAL RESOURCES AND ENVIRONMENTAL STEWARDSHIP, AND ECONOMIC AND SOCIAL WELLBEING, THEREBY IMPROVING THE LIVES OF PEOPLE IN PENNSYLVANIA, THE NATION, AND THE WORLD.' AGRICULTURE FACES CHALLENGES OF RISING ENERGY COSTS, WEATHER EXTREMES, AN EXPANDING HUMAN POPULATION, ENVIRONMENTAL DEGRADATION, LOSS OF BIODIVERSITY, AND LABOR SHORTAGES. THE COVID?19 PANDEMIC ADDED TO THE CHALLENGES: DISRUPTIONS TO FOOD CHAINS, WORKFORCE CHALLENGES, IMPACTS ON YOUTH EDUCATION, AND BUSINESS INTERRUPTIONS. WE MUST ADDRESS THESE ISSUES TO MITIGATE FUTURE WIDESPREAD DISRUPTIONS THAT IMPACT ALL OF SOCIETY. ACTIVITIES: TO HELP MEET THESE CHALLENGES, WE ARE DEVELOPING A CONCEPTUAL FRAMEWORK BASED ON THE SCIENCE OF AGRICULTURAL SUSTAINABILITY DEFINED AS THE INTEGRATION OF NATURAL AND SOCIAL SCIENCES TO INFORM PRACTICE AND POLICY FOR PRODUCTIVE, WORKING LANDSCAPES, HEALTHY WATERSHEDS, AND RESILIENT ECONOMIES. THIS INNOVATIVE APPROACH TO AGRICULTURAL RESEARCH, ENGAGEMENT, AND EDUCATION CENTERS ON THE IMPACTS AND SYNERGIES OF CONTIGUOUS RURAL AND URBAN LANDSCAPES. PENN STATE EXTENSION PROVIDES ACCESS TO FACE?TO?FACE AND ONLINE SCIENCE BASED EDUCATION TO OUR CUSTOMERS TO HELP THEM ADDRESS PROBLEMS AND TAKE ADVANTAGE OF OPPORTUNITIES FOR IMPROVEMENT AND INNOVATION. WE MAKE A DIFFERENCE LOCALLY THROUGH FOCUSED ENGAGEMENT AND, MORE WIDELY, TO CUSTOMERS CONNECTING IN THE DIGITAL LANDSCAPE. INITIATIVES ENSURE THE STABILITY OF THE FOOD SYSTEM IN THE COMMONWEALTH AND OUR EFFORTS TO PROVIDE A BROAD?BASED ONLINE LEARNING PLATFORM FOR NONCREDIT PROGRAMMING AND DIGITAL EDUCATION. THE WORK OF AES AND PSE IN OUR COLLEGE IS BUILT ON THE THREE INTEGRATED PILLARS OF INTENSIFICATION, RESILIENCE, AND REGENERATION OF AGRICULTURAL LANDSCAPES AS SOLUTIONS TO SOME OF THE MOST VEXING PROBLEMS CONFRONTING PENNSYLVANIA AND SIMILAR MOSAIC LANDSCAPES WORLDWIDE. OUR CRITICAL ISSUES CAPTURE THE SYSTEMS APPROACH WE IDENTIFIED AS ESSENTIAL FOR GENERATING IMPACT. THEY CUT ACROSS DISCIPLINES, UNITING OUR RESEARCH EFFORTS WITH OUR EXTENSION EDUCATION CAPACITY. THIS INTERDISCIPLINARY PHILOSOPHY HAS REINFORCED THE NATURAL TENDENCY OF OUR FACULTY AND EXTENSION EDUCATORS TO WORK COOPERATIVELY TO SOLVE PROBLEMS. COUPLED WITH THE JOINT RESEARCH?EXTENSION APPOINTMENTS OF MANY OF OUR COLLEGE FACULTY, OUR WORK, AS REPRESENTED IN OUR PLAN OF WORK, WILL EFFECTIVELY UNITE FUNDAMENTAL KNOWLEDGE WITH PRACTICAL SOLUTIONS DELIVERED TO STAKEHOLDERS, EMPOWERING THEM TO ADDRESS I MPORTANT AND EMERGING ISSUES USING RELEVANT SCIENCE?BASED RESOURCES. THE NET RESULT WILL BE A TANGIBLE BENEFIT IN ECONOMIC PROSPERITY AND QUALITY OF LIFE FOR PENNSYLVANIA CITIZENS.

THE COLLEGE OF AGRICULTURAL SCIENCES AT PENN STATE WILL PROVIDE COMPREHENSIVE SUPPORT TO PENNSYLVANIA RESIDENTS THROUGH THE PENNSYLVANIA AGRICULTURAL EXPERIMENT STATION (AES) AND PENN STATE EXTENSION PSE ACTIVITIES. WE WILL BE RESPONSIVE TO STAKEHOLDER NEEDS THROUGH TRANSLATIONAL RESEARCH AND DELIVERY OF SCIENCE?BASED PROGRAMS TO CLIENTELE. WE WILL ALSO CONDUCT INTERNATIONALLY RELEVANT FUNDAMENTAL RESEARCH THAT GENERATES BASELINE DATA TO SOLVE FUTURE PROBLEMS AND ACTIVELY SEEK NEW AND BETTER WAYS TO COMMUNICATE OUR PROGRAMS TO NEW AUDIENCES. OUR FACULTY AND STAFF, SUPPORTED BY FEDERAL BASE FUNDING, WILL EFFECTIVELY LEVERAGE THIS INVESTMENT AGAINST MANY OTHER FUNDING SOURCES TO CONDUCT PROGRAMS OF THE HIGHEST CALIBER. WE ARE COMMITTED TO EXCELLENCE IN RESEARCH, EDUCATING THE NEXT GENERATION OF AGRICULTURAL PROFESSIONALS AND CITIZENS, AND PROMOTING LIFE?LONG LEARNING AMONG THE CITIZENS OF PENNSYLVANIA. OUR COLLEGE'S MISSION IS CLEAR: THE MISSION OF THE COLLEGE OF AGRICULTURAL SCIENCES IS TO DISCOVER, INTEGRATE, TRANSLATE, AND DISSEMINATE KNOWLEDGE TO ENHANCE THE FOOD AND AGRICULTURAL SYSTEM, NATURAL RESOURCES AND ENVIRONMENTAL STEWARDSHIP, AND ECONOMIC AND SOCIAL WELLBEING, THEREBY IMPROVING THE LIVES OF PEOPLE IN PENNSYLVANIA, THE NATION, AND THE WORLD. AGRICULTURE FACES CHALLENGES OF RISING ENERGY COSTS, WEATHER EXTREMES, AN EXPANDING HUMAN POPULATION, ENVIRONMENTAL DEGRADATION, LOSS OF BIODIVERSITY, AND LABOR SHORTAGES. THE COVID?19 PANDEMIC ADDED TO THE CHALLENGES DISRUPTIONS TO FOOD CHAINS, WORKFORCE CHALLENGES, IMPACTS ON YOUTH EDUCATION, AND BUSINESS INTERRUPTIONS. WE MUST ADDRESS THESE ISSUES TO MITIGATE FUTURE WIDESPREAD DISRUPTIONS THAT IMPACT ALL OF SOCIETY. ACTIVITIES: TO HELP MEET THESE CHALLENGES, WE ARE DEVELOPING A CONCEPTUAL FRAMEWORK BASED ON THE SCIENCE OF AGRICULTURAL SUSTAINABILITY DEFINED AS THE INTEGRATION OF NATURAL AND SOCIAL SCIENCES TO INFORM PRACTICE AND POLICY FOR PRODUCTIVE, WORKING LANDSCAPES, HEALTHY WATERSHEDS, AND RESILIENT ECONOMIES. THIS INNOVATIVE APPROACH TO AGRICULTURAL RESEARCH, ENGAGEMENT, AND EDUCATION CENTERS ON THE IMPACTS AND SYNERGIES OF CONTIGUOUS RURAL AND URBAN LANDSCAPES. PENN STATE EXTENSION PROVIDES ACCESS TO FACE TO FACE AND ONLINE SCIENCE BASED EDUCATION TO OUR CUSTOMERS TO HELP THEM ADDRESS PROBLEMS AND TAKE ADVANTAGE OF OPPORTUNITIES FOR IMPROVEMENT AND INNOVATION. WE MAKE A DIFFERENCE LOCALLY THROUGH FOCUSED ENGAGEMENT AND, MORE WIDELY, TO CUSTOMERS CONNECTING IN THE DIGITAL LANDSCAPE. INITIATIVES ENSURE THE STABILITY OF THE FOOD SYSTEM IN THE COMMONWEALTH AND OUR EFFORTS TO PROVIDE A BROAD BASED ONLINE LEARNING PLATFORM FOR NONCREDIT PROGRAMMING AND DIGITAL EDUCATION. THE WORK OF AES AND PSE IN OUR COLLEGE IS BUILT ON THE THREE INTEGRATED PILLARS OF INTENSIFICATION, RESILIENCE, AND REGENERATION OF AGRICULTURAL LANDSCAPES AS SOLUTIONS TO SOME OF THE MOST VEXING PROBLEMS CONFRONTING PENNSYLVANIA AND SIMILAR MOSAIC LANDSCAPES WORLDWIDE. OUR CRITICAL ISSUES CAPTURE THE SYSTEMS APPROACH WE IDENTIFIED AS ESSENTIAL FOR GENERATING IMPACT. THEY CUT ACROSS DISCIPLINES, UNITING OUR RESEARCH EFFORTS WITH OUR EXTENSION EDUCATION CAPACITY. THIS INTERDISCIPLINARY PHILOSOPHY HAS REINFORCED THE NATURAL TENDENCY OF OUR FACULTY AND EXTENSION EDUCATORS TO WORK COOPERATIVELY TO SOLVE PROBLEMS. COUPLED WI TH THE JOINT RESEARCH EXTENSION APPOINTMENTS OF MANY OF OUR COLLEGE FACULTY, OUR WORK, AS REPRESENTED IN OUR PLAN OF WORK, WILL EFFECTIVELY UNITE FUNDAMENTAL KNOWLEDGE WITH PRACTICAL SOLUTIONS DELIVERED TO STAKEHOLDERS, EMPOWERING THEM TO ADDRESS IMPORTANT AND EME RGING ISSUES USING RELEVANT SCIENCE?BASED RESOURCES. THE NET RESULT WILL BE A TANGIBLE BENEFIT IN ECONOMIC PROSPERITY AND QUALITY OF LIFE FOR PENNSYLVANIA CITIZENS.

COOPERATIVE EXTENSION PROGRAM AT 1862 LAND GRANT INSTITUTIONS

COOPERATIVE EXTENSION PROGRAM AT 1862 LAND GRANT INSTITUTION

COOPERATIVE EXTENSION PROGRAM AT 1862 LAND GRANT INSTITUTIONS

COOPERATIVE EXTENSION PROGRAM AT 1862 LAND GRANT INSTITUTIONS

COOPERATIVE EXTENSION PROGRAM AT 1862 LAND GRANT INSTITUTION

COOPERATIVE EXTENSION PROGRAM AT 1862 LAND GRANT INSTITUTION.

THE BIOSTATISTICS RESEARCH CENTER FOR THE IMPAIRED AWARENESS OF HYPOGLYCEMIA CONSORTIUM - ABSTRACT INDIVIDUALS WITH TYPE 1 DIABETES (T1D) ARE SUSCEPTIBLE TO REPEATED EPISODES OF HYPOGLYCEMIA, WHICH CAN RESULT IN IMPAIRED AWARENESS OF HYPOGLYCEMIA (IAH). AS A CONSEQUENCE, IAH CONTRIBUTES TO DIMINISHED RECOGNITION OF THE NEED FOR EXTERNAL GLUCOSE AND THE BLUNTING OF COUNTER-REGULATORY RESPONSES THAT ARE REQUIRED TO INCREASE BLOOD GLUCOSE. THIS CAN BE A VERY RISKY SITUATION FOR T1D INDIVIDUALS WITH IAH, POSSIBLY LEADING TO COMA AND IN SOME CIRCUMSTANCES, DEATH. THIS CAN BE A VERY RISKY SITUATION FOR T1D INDIVIDUALS WITH IAH, POSSIBLY LEADING TO COMA AND IN SOME CIRCUMSTANCES, DEATH. MANY T1D STUDIES EXCLUDE IAH INDIVIDUALS BECAUSE OF CONFOUNDING ISSUES. THEREFORE, THE NATIONAL INSTITUTE FOR DIABETES AND DIGESTIVE AND KIDNEY DISEASES (NIDKK) HAS ISSUED TWO RFAS TO FORM THE IAH CONSORTIUM THAT WILL INVESTIGATE FACTORS WHICH CONTRIBUTE TO THE HETEROGENEITY OF RESTORATION OF AWARENESS OF HYPOGLYCEMIA IN ADULT T1D INDIVIDUALS WITH IAH. RFA-DK-21-020 AND RFA-DK-21- 036 REQUEST APPLICATIONS FOR CLINICAL CENTERS AND THE SOLE BIOSTATISTICS RESEARCH CENTER (BRC), RESPECTIVELY. THE OBJECTIVES OF THE IAH CONSORTIUM WILL BE TO - DETERMINE IF THE MOST UP-TO-DATE MANAGEMENT STRATEGIES USING DIABETES TECHNOLOGY TO OPTIMIZE HBA1C WHILE MINIMIZING HYPOGLYCEMIA CAN RESTORE AWARENESS OF HYPOGLYCEMIA AND IMPROVE COUNTER-REGULATORY RESPONSES IN INDIVIDUALS WITH T1D AND IAH - IDENTIFY THE MAGNITUDE AND DURATION OF TIME IN RANGE, TIME SPENT IN HYPOGLYCEMIA OR OTHER METRICS FOR CONTINUOUS GLUCOSE MONITORS THAT ARE ASSOCIATED WITH RESTORATION OF AWARENESS OF HYPOGLYCEMIA - DETERMINE THE ASSOCIATION OF CURRENT OR NEWLY DEVELOPED SELF-REPORTED MEASURES OF IAH WITH COUNTER- REGULATORY RESPONSES TO ELUCIDATE THE HETEROGENEITY IN RESTORATION OF HYPOGLYCEMIA AWARENESS THE DEPARTMENT OF PUBLIC HEALTH SCIENCES AT THE PENNSYLVANIA STATE UNIVERSITY COLLEGE OF MEDICINE PROPOSES TO SERVE AS THE BRC FOR THE IAH CONSORTIUM, AND WILL PURSUE SEVEN SPECIFIC AIMS. SPECIFIC AIM 1: COLLABORATE ON THE DEVELOPMENT AND CONDUCT OF STUDIES, AND LEAD STATISTICAL ANALYSES SPECIFIC AIM 2: LEAD THE CONSORTIUM IN DEVELOPING MEASURES OF SELF-REPORTED IAH SPECIFIC AIM 3: HOUSE A CENTRAL LABORATORY SPECIFIC AIM 4: LEAD THE CONSORTIUM IN STAKEHOLDER ENGAGEMENT SPECIFIC AIM 5: DEVELOP DATA MANAGEMENT AND WEBSITE PROCESSES SPECIFIC AIM 6: MAINTAIN REGULATORY COMPLIANCE SPECIFIC AIM 7: PROVIDE COMMUNICATION AND PROJECT MANAGEMENT SUPPORT

COOPERATIVE EXTENSION PROGRAM AT 1862 LAND-GRANT INSTITUTION

COOPERATIVE EXTENSION PROGRAMS AT 1862 LAND-GRANT INSITUTION

(MURI) PROGRAMMABLE SYSTEMS WITH NON-HERMITIAN QUANTUM DYNAMICS

GRADUATE RESEARCH FELLOWSHIP PROGRAM (GRFP)

CLEARINGHOUSE FOR MILITARY FAMILY READINESS AT PENN STATE

TAS::89 0328::TAS RECOVERY ACT - GRID STAR: SMART GRID TRAINING AND APPLICATION RESOURCE CENTER

INFLATION REDUCTION ACT (IRA) – COMMUNITY-ORIENTED METHANE AND CO-POLLUTANT EMISSION MEASUREMENTS IN THE APPALACHIAN REGION (COMPEAR) THIS PROJECT WILL MEASURE EMISSIONS OF METHANE AND CO-EMITTED SPECIES IN AND AROUND CJ/EJ COMMUNITIES IN THE APPALACHIAN REGION. THE PROJECT WILL USE BOTH MOBILE AND STATIONARY MEASUREMENTS AND WILL EMPLOY A UNIQUELY COMMUNITY-ORIENTED MEASUREMENT STRATEGY. CHEMICAL FINGERPRINTING WILL BE A CENTRAL ELEMENT OF THE PROJECT METHODOLOGY. CHEMICAL FINGERPRINTING WILL IMPROVE BOTH METHANE SOURCE ATTRIBUTION AND CO-EMITTED SPECIES INVENTORIES, OFTEN A HIGH PRIORITY CONCERN FOR COMMUNITY MEMBERS. THE PROJECT WILL WORK CLOSELY WITH COMMUNITY AND INDUSTRY ADVISORY GROUPS AND HEALTH SCIENCES PROFESSIONALS TO MAXIMIZE COMMUNITY BENEFITS OF THE STUDY.

CENTER: NATIONAL SYNTHESIS CENTER FOR EMERGENCE IN THE MOLECULAR AND CELLULAR SCIENCES -THE NATIONAL SYNTHESIS CENTER FOR EMERGENCE IN THE MOLECULAR AND CELLULAR SCIENCES (NCEMS) IS A NATIONAL RESOURCE DRIVING INNOVATION BY ENABLING INTERDISCIPLINARY TEAMS OF SCIENTISTS TO SYNTHESIZE DIVERSE DATA AND COMPUTATIONAL METHODOLOGIES TO GAIN DEEPER AND BROADER INSIGHTS INTO LIVING SYSTEMS. RECOGNIZING THE UNTAPPED POTENTIAL IN THE UNPRECEDENTED GROWTH OF DATA ON THE SMALLEST SCALES IN BIOLOGY, NCEMS WILL CATALYZE AND SUPPORT A SUITE OF ACTIVITIES TO UNDERSTAND HOW NEW CELLULAR FEATURES AND PHENOMENA CENTRAL TO LIFE EMERGE FROM THE PROPERTIES AND INTERACTIONS OF MOLECULES. INITIALLY, NCEMS WILL FOCUS ON CHARACTERIZING EMERGENT PROPERTIES AT THE MESOSCALE ? DEFINED AS THE SPATIAL SCALE BETWEEN MOLECULES AND CELLULAR ORGANELLES ? AND THEIR INFLUENCE ON HIGHER ORDER SUBCELLULAR AND CELLULAR SYSTEMS. THE CENTER WILL ACCOMPLISH THIS MISSION BY ACCELERATING SYNTHESIS RESEARCH ACROSS THEMES, INCLUDING: (1) EMERGENCE OF MESOSCALE BIOMOLECULAR ORGANIZATION AND FUNCTION, (2) DATA-DRIVEN DISCOVERY OF EMERGENT PROPERTIES, (3) DISSECTION OF EMERGENT PROPERTIES THROUGH CROSS-SPECIES COMPARISONS, (4) MODELING EMERGENT PROPERTIES USING DENSE MESOSCALE DATA, AND (5) APPLYING CROSS-CUTTING DATA SCIENCE TECHNIQUES INCLUDING MACHINE LEARNING AND ARTIFICIAL INTELLIGENCE. NCEMS WILL REALIZE ITS VISION TO EXPEDITE LARGE-SCALE SYNTHESIS RESEARCH AND OPEN NEW FRONTIERS IN MOLECULAR AND CELLULAR BIOSCIENCES BY LOWERING BARRIERS TO DIVERSE DATA INTEGRATION BY SCIENTISTS ACROSS DIFFERENT DISCIPLINES, SUPPORTING TRANSFER OF METHODOLOGIES ACROSS FIELDS, AND ENSURING THAT WORKING KNOWLEDGE IS WIDELY AVAILABLE. IN PARALLEL, NCEMS WILL ADVANCE TRAINING AND BROAD PARTICIPATION OF THE COMMUNITY IN DATA-INTENSIVE SCIENCE BY INTEGRATING INNOVATIVE AND INCLUSIVE LEARNING APPROACHES IN ALL CENTER ACTIVITIES. NCEMS IS A TRANSFORMATIVE FORCE IN DATA-DRIVEN RESEARCH ON EMERGENT PROPERTIES IN MOLECULAR AND CELLULAR SYSTEMS. THE CENTER'S SCIENTIFIC VISION IS TO UNDERSTAND THE APPEARANCE OF NEW BIOLOGICAL SYSTEM PROPERTIES AT DIFFERENT SCALES OF COMPOSITION, SPACE, TIME, ENERGY, INFORMATION, AND MOTION. THE COMPLEXITY AND LACK OF UNDERSTANDING OF MESOSCALE PHENOMENA AND THE AVAILABILITY OF VAST AMOUNTS OF PUBLICLY AVAILABLE DATA SPANNING MOLECULAR TO PHENOTYPIC PROPERTIES MAKE THIS AN IDEAL INITIAL FOCUS FOR THE CENTER. THESE DATA CONTINUE TO BE GENERATED AT A PRODIGIOUS RATE THROUGH NEXT-GENERATION SEQUENCING, MASS SPECTROMETRY, CRYO-EM AND -ET, IMAGING, AND HIGH-THROUGHPUT BIOCHEMICAL TECHNIQUES ON DIVERSE ORGANISMS UNDER MANY CONDITIONS. NCEMS LEVERAGES THE DATA AND BRINGS TOGETHER SCIENTISTS WITH DIVERSE EXPERTISE AND PERSPECTIVES FROM THE PHYSICAL, BIOLOGICAL, AND DATA SCIENCES, AND SUPPORTS THEM WITH COMPUTATIONAL AND HUMAN RESOURCES TO TACKLE THE MOST CONFOUNDING SYNTHESIS QUESTIONS AND PURSUE PATHBREAKING IDEAS IN THIS AREA. SPECIFICALLY, NCEMS SUPPORTS THE COMMUNITY IN CARRYING OUT TEAM AND OPEN SCIENCE; ENABLES COLLABORATION THROUGH CLOUD-AGNOSTIC CYBERINFRASTRUCTURE PROVIDED BY CYVERSE AT THE UNIVERSITY OF ARIZONA; PROVIDES TRAINING IN ESSENTIAL ELEMENTS OF DATA SCIENCE, MACHINE LEARNING, STATISTICS, AND REPRODUCIBLE SCIENCE; AND OFFERS NATIONWIDE OPPORTUNITIES TO PARTICIPATE IN NCEMS RESEARCH REMOTELY. NCEMS IS ALSO BUILDING A ROBUST PROGRAM FOR UNDERGRADUATE STUDENTS, PARTICULARLY THOSE UNDERREPRESENTED IN STEM DISCIPLINES, TO PARTICIPATE IN SYNTHESIS RESEARCH AND BENEFIT FROM MENTORSHIP AND EXPERIENTIAL LEARNING OPPORTUNITIES. INITIAL PARTNERS IN THIS PROGRAM INCLUDE CLAFLIN, ALCORN STATE, AND FAYETTEVILLE STATE UNIVERSITIES. ALL NCEMS EDUCATIONAL ACTIVITIES EMPHASIZE BROAD PARTICIPATION OF THE COMMUNITY THROUGH WORKSHOPS, TRAINING EVENTS, AND RESEARCH-BASED LEARNING OPPORTUNITIES AIMED AT DEVELOPING A WORKFORCE COMPETENT IN COMPUTATIONAL AND DATA SCIENCES. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE PLANNED FOR THIS AWARD.

DATA COORDINATING CENTER FOR THE NATURAL HISTORY OF AKI CONSORTIUM

COOPERATIVE EXTENSION PROGRAMS AT 1862 LAND-GRANT INSTITUTION

ACUTE AND CHRONIC AFFERENT ENGAGEMENT: SYMPATHETIC AND END ORGAN RESPONSES

HEAD START REDI (RESEARCH-BASED, DEVELOPMENTALLY INFORMED)

THIS PROJECT SEEKS TO CREATE ECONOMICALLY THRIVING AND ENVIRONMENTALLY BENEFICIAL AGRICULTURAL SYSTEMS IN URBANIZED LANDSCAPES. THESE AGRICULTURAL SYSTEMS ARE LOCATED IN METROPOLITAN COUNTIES AND IN NON-METROPOLITAN COUNTIES ADJACENT TO METRO AREAS, AND ARE VITAL TO THE SUSTAINABILITY OF U.S. AGRICULTURE. OUR CENTRAL HYPOTHESIS IS THAT VALUE-ADDED AGRICULTURE OF THE KIND REQUIRED TO BE ECONOMICALLY SUSTAINABLE IN URBANIZED LANDSCAPES CAN BE ACHIEVED WHILE ENHANCING ECOSYSTEM SERVICES. OUR OVERALL GOAL IS TO MAKE THIS HYPOTHESIS A REALITY WITHIN THE 25-YEAR PERIOD STATED IN THE RFA, USING THE CHESAPEAKE BAY WATERSHED AS A CASE STUDY TRANSLATABLE TO OTHER URBANIZED LANDSCAPES. THIS PROJECT WILL ENGAGE CLOSELY WITH STAKEHOLDERS USING A SHARED DISCOVERY AND CO-LEARNING PROCESS TO ENVISION DESIRED 25-YEAR FUTURES FOR AGRICULTURAL SYSTEMS IN URBANIZED LANDSCAPES THAT ARE ECONOMICALLY SUSTAINABLE WHILE ENHANCING ECOSYSTEM SERVICES; AND CONDUCT SCENARIO-BUILDING EXERCISES WITH STAKEHOLDERS TO IDENTIFY HOW AGRICULTURE IN URBANIZED AREAS WOULD NEED TO EVOLVE TO REALIZE THESE DESIRED FUTURES, AND THE TECHNOLOGIES, MARKETS, AND PUBLIC POLICIES THAT COULD HELP MAKE THE DESIRED FUTURES A REALITY.THIS PROJECT WILL CARRY OUT ITERATIVE RESEARCH PROCESSES WITH STAKEHOLDERS ON INCREASING TFP THROUGH ENLARGED MARKETS IN URBANIZED LANDSCAPES FOR LOCAL, ORGANIC, AND TRACEABLE FOOD PRODUCTS; AND ON IMPROVING NUE AND TFP THROUGH A SUITE OF NUTRIENT MANAGEMENT TOOLS, MODELS, AND ANALYSES FOR FARMERS, COMPANIES SELLING DATA ANALYTICS SERVICES TO FARMERS, LAND USE PLANNERS, AND AGRICULTURAL AND ENVIRONMENTAL POLICY-MAKERS. WE WILL IMPLEMENT THE RECOMMENDATIONS COMING OUT OF THE SCENARIO-BUILDING EXERCISES THROUGH MODELLING, EXPERIMENTS, SURVEYS, AND DEMONSTRATIONS; BRING THE RESULTS TO STAKEHOLDERS TO EVALUATE; AND CARRY OUT ADDITIONAL RESEARCH BASED ON FEEDBACK FROM STAKEHOLDERS. EXPECTED OUTCOMES FROM OUR STAKEHOLDER-LED APPROACH INCLUDE RAPID UPTAKE OF THE PROJECT'S RESEARCH OUTPUTS BECAUSE THEY WILL ADDRESS PRESENT-DAY NEEDS AND DESIRED FUTURES IDENTIFIED BY STAKEHOLDERS.

PREVENTION AND METHODOLOGY TRAINING (PAMT)

COOPERATIVE EXTENSION PROGRAM AT 1862 LAND GRANT INSTITUTION.

COOPERATIVE EXTENSION PROGRAM AT 1862 LAND GRANT INSTITUTION

DYNAMIC VISUALIZATION AND CONTROL OF EMERGENT PHASES IN COMPLEX OXIDE HETEROSTRUCTURES

DEMOCRATIZATION OF DATA ANALYSIS IN LIFE SCIENCES THROUGH GALAXY - PROJECT SUMMARY FOR OVER A DECADE, THE GALAXY PROJECT (HTTPS://GALAXYPROJECT.ORG/) HAS WORKED TO SOLVE KEY ISSUES PLAGUING MODERN DATA INTENSIVE BIOLOGY -- THE ABILITY OF RESEARCHERS TO ACCESS CUTTING-EDGE ANALYSIS METHODS, TO SHARE ANALYSIS RESULTS TRANSPARENTLY, AND TO PRECISELY REPRODUCE COMPLEX COMPUTATIONAL ANALYSES. GALAXY HAS BECOME ONE OF THE LARGEST AND MOST WIDELY USED OPEN SOURCE PLATFORMS FOR BIOLOGICAL DATA SCIENCE. PROMOTING OPENNESS AND COLLABORATION IN ALL FACETS OF THE PROJECT, FROM TECHNICAL DECISIONS TO TRAINING AND LEADERSHIP, HAS ENABLED US TO BUILD A VIBRANT COMMUNITY OF USERS, DEVELOPERS, SYSTEM ENGINEERS, AND EDUCATORS WHO CONTINUOUSLY CONTRIBUTE NEW SOFTWARE FEATURES, ADD THE LATEST TOOLS, ADOPT TO THE MOST MODERN INFRASTRUCTURE, AUTHOR TRAINING MATERIALS, AND LEAD RESEARCH AND TRAINING WORKSHOPS. GENOMICS RESEARCH IS CONTINUOUSLY EVOLVING, AND CURRENT CHALLENGES INCLUDE THE RAPID GROWTH IN SIZE AND COMPLEXITY OF NEW DATASETS, THE INCREASING AVAILABILITY OF CONTROLLED-ACCESS DATASETS WITH HUMAN GENOMIC COMPONENTS, AND THE CONTINUING EXPANSION IN THE BREADTH OF RESEARCH AREAS CAPABLE OF GENERATING HIGH THROUGHPUT DATA. THE CORE GALAXY DEVELOPMENT TEAM SUBMITTING THIS PROPOSAL WILL RESPOND TO THESE CHALLENGES BY FOCUSING ON THE FOLLOWING KEY PRIORITIES: - REARCHITECT GALAXY FOR SCALABILITY AND SECURITY USING SOFTWARE CONTAINER TECHNOLOGIES; - DESIGN NEW USER INTERFACE (UI) FOR WORKING WITH THOUSANDS OF TOOLS, WORKFLOWS, AND SAMPLES; - ENABLE INTERACTIVE EXPLORATORY DATA ANALYSIS IN GALAXY; - FACILITATE COMMUNITY GROWTH AND SUPPORT; - ENABLE EFFECTIVE TRAINING AND OUTREACH. CONCENTRATING ON THESE BROAD PRIORITIES WILL ALLOW US TO ACHIEVE THE ULTIMATE GOAL OF THE GALAXY PROJECT: DEVELOPING A DATA ANALYSIS MEDIUM CONNECTING BIOMEDICAL EXPERTS ACROSS THE FULL SPECTRUM OF SKILL SETS, SCIENTIFIC DOMAINS, AND RESEARCH PRACTICES. FOR BIOMEDICAL RESEARCHERS IT WILL PROVIDE A POWERFUL ANALYSIS PLATFORM POPULATED WITH THE LATEST TOOLS AND DATA. FOR TOOL DEVELOPERS IT WILL PROVIDE A COMMUNITY-SUPPORTED MECHANISM FOR DEPLOYING TOOLS BEFORE A WIDE AUDIENCE OF USERS. FOR SYSTEM ADMINISTRATORS AND ENGINEERS IT WILL PROVIDE A FRAMEWORK THEY WILL FEEL COMFORTABLE DEPLOYING ON ANY INFRASTRUCTURE. FOR EDUCATORS IT WILL PROVIDE A COMPREHENSIVE COLLECTION OF MATERIALS COVERING MOST DATA ANALYSIS NEEDS AND AN INFRASTRUCTURE FOR DELIVERING INTERACTIVE, HANDS-ON TRAINING WORKSHOPS FOR AUDIENCES OF DIFFERENT SIZES.

NORTHEASTERN REGIONAL CENTER OF THE NATIONAL INSTITUTE FOR CLIMATE CHANGE RESEARCH

TITLE: SIGNATURES OF LIFE FROM EARTH AND BEYOND IS IN RESPONSE TO CAN #NNH08ZDA002C NASA ASTROBIOLOGY INSTITUTE - CYCLE 5 BASIC AWARD FOR CYCLE FIVE OF NAI TO PENN STATE.1260.51 COOPERATIVE AGREEMENT SPECIAL CONDITION. (OCTOBER 2000) (A) THIS AWARD IS A COOPERATIVE AGREEMENT AS IT IS ANTICIPATED THERE WILL BE SUBSTANTIAL NASA INVOLVEMENT DURING PERFORMANCE OF THE EFFORT. NASA AND THE RECIPIENT MUTUALLY AGREE TO THE FOLLOWING STATEMENT OF ANTICIPATED COOPERATIVE INTERACTIONS WHICH MAY OCCUR DURING THE PERFORMANCE OF THIS EFFORT: NAI CENTRAL IS RESPONSIBLE FOR COORDINATING INSTITUTE ACTIVITIES ADVOCATING THE NEEDS & SCIENTIFIC INTERESTS OF THE MEMBERS OF THIS COOPERATIVE AGREEMENT DISBURSING FUNDS (INCLUDING A STRATEGIC DIRECTOR S DISCRETIONARY FUND FOR HIGH-RISK/HIGH-PAYOFF RESEARCH PROJECTS AND FOR FOSTERING COLLABORATION BETWEEN MEMBERS) SPONSORING THE NAI POSTDOCTORAL FELLOWSHIP PROGRAM COLLECTING AND ARCHIVING INFORMATION ON RESEARCH ACCOMPLISHMENTS & PUBLICATIONS ORGANIZING FOCUS GROUP MEETINGS & WORKSHOPS & EXPEDITING NETWORK CONNECTIVITY WHILE ENGINEERING THE INTERFACES BETWEEN THE SCIENTISTS & THE NETWORK. NAI CENTRAL IS ALSO RESPONSIBLE FOR ORGANIZING GENERAL MEETINGS WORKSHOPS & STRATEGIC RETREATS TO ENGAGE MEMBERS OF THE INSTITUTE IN INTEGRATED RESEARCH. NAI CENTRAL WILL IN ADDITION COORDINATE INSTITUTE-WIDE ACTIVITIES IN EDUCATION & PUBLIC OUTREACH & IN THE TRAINING OF STUDENTS & OTHER YOUNG INVESTIGATORS.AT THE CORE OF ASTROBIOLOGY IS THE CONSTRUCTION OF SCIENTIFIC KNOWLEDGE THAT ENABLES THE RECOGNITION OF SIGNATURES OF LIFE ON EARLY EARTH IN EXTREME ENVIRONMENTS AND IN EXTRATERRESTRIAL SETTINGS. TOGETHER WITH NEW CO-INVESTIGATORS FROM UNIVERSITY OF CALIFORNIA LOS ANGELES AND CALIFORNIA INSTITUTE OF TECHNOLOGY WE PROPOSE TO DEVELOP NOVEL APPROACHES TO DETECTING AND CHARACTERIZING LIFE INVESTIGATE BIOSIGNATURES IN MISSION-RELEVANT ECOSYSTEMS AND ANCIENT ROCKS AND EVALUATE THE POTENTIAL FOR BIOSIGNATURES IN EXTRATERRESTRIAL SETTINGS.(1) DEVELOPING NEW BIOSIGNATURES THE DEVELOPMENT AND TESTING OF POTENTIAL INDICATORS OF LIFE IS ESSENTIAL FOR PROVIDING A CRITICAL SCIENTIFIC BASIS FOR EXPLORATION OF LIFE IN THE COSMOS. OUR EFFORTS WILL FOCUS ON CREATING INNOVATIVE APPROACHES FOR THE ANALYSES OF CELLS AND OTHER ORGANIC MATERIAL FINDING WAYS IN WHICH METAL ABUNDANCES AND ISOTOPE SYSTEMS REFLECT LIFE AND DEVELOPING CREATIVE APPROACHES FOR USING ENVIRONMENTAL DNA TO STUDY PRESENT AND PAST LIFE.(2) BIOSIGNATURES IN RELEVANT MICROBIAL ECOSYSTEMS PSARC WILL INVESTIGATE MICROBIAL LIFE IN SOME OF EARTH S MOST MISSION-RELEVANT ECOSYSTEMS THE DEAD SEA THE CHESAPEAKE IMPACT STRUCTURE THE METHANE SEEPS OF THE EEL RIVER BASIN AND THE GREENLAND GLACIER ICE.(3) BIOSIGNATURES IN ANCIENT ROCKS THE EARTH S ARCHEAN AND PROTEROZOICEONS OFFER THE BEST OPPORTUNITY OF INVESTIGATING A MICROBIAL WORLD SUCH AS MIGHT BE FOUND ELSEWHERE IN THE COSMOS. THE ANCIENT RECORD ON EARTH PROVIDES ON OPPORTUNITY TO SEE WHAT GEOCHEMICAL SIGNATURES ARE PRODUCED BY MICROBIAL LIFE AND HOW THESE SIGNATURES ARE PRESERVED OVER GEOLOGIC TIME.(4) BIOSIGNATURES IN EXTRATERRESTRIAL SETTING. PSARC WILL INVESTIGATE THE ABUNDANCE OF SULFUR GASES AND ELUCIDATE HOW THESE GASES CAN BE EXPECTED TO EVOLVE WITH TIME ON YOUNG TERRESTRIAL PLANETS. WE WILL CONTINUE STUDIES OF PLANET FORMATION IN THE PRESENCE OF MIGRATION AND MODEL RADIAL TRANSPORT OF VOLATILES IN YOUNG PLANETARY SYSTEMS. FINAL PSARC WILL BE INVOLVED WITH SEARCHES FOR M STAR PLANETARY COMPANIONS AND PLANETS AROUND K-GIANT STARS.(B) THE TERMS ....(C) NASA S ABILITY TO PARTICIPATE ....

USE OF A GLP-1 AGONIST TO TREAT OPIOID USE DISORDER IN RATS AND MAN - PROJECT SUMMARY. ACCORDING TO THE CENTERS FOR DISEASE CONTROL AND PREVENTION, THERE WERE 70,237 DRUG OVERDOSE DEATHS REPORTED IN THE UNITED STATES IN 2017, MORE THAN 130 PER DAY, WITH 67.8% INVOLVING OPIOIDS [1]. WHILE MEDICATIONS ARE AVAILABLE TO TREAT THE DISEASE (E.G., METHADONE, SUBOXONE, AND EXTENDED RELEASE NALTREXONE), RELAPSE RATES REMAIN ALARMINGLY HIGH [2-4]. CLEARLY, NEW APPROACHES ARE NEEDED. TO THIS END, WE RECOGNIZE THAT ADDICTION INVOLVES NOT ONLY HIJACKING OF THE REWARD PATHWAY, BUT ALSO OF THE NEED PATHWAY [5]. AS SUCH, WE POSITED THAT HEROIN SEEKING AND TAKING SHOULD BE REDUCED BY PERIPHERAL STIMULATION OF THE GLUCAGON- LIKE PEPTIDE-1 RECEPTOR (GLP-1R) ‘SATIETY’ PATHWAY. IN SUPPORT, ACTIVATION OF THE GLP-1R PATHWAY HAS BEEN SHOWN TO INHIBIT NOT ONLY INGESTION OF PALATABLE SWEETS, WATER WHEN THIRSTY, AND SALT WHEN SODIUM DEPRIVED, BUT ALSO RESPONDING FOR ALCOHOL, NICOTINE, AND COCAINE IN RATS AND MICE [6-12]. HERE, WE SHOW FOR THE FIRST TIME THAT PRETREATMENT WITH A GLP-1R AGONIST ALSO REDUCES HEROIN TAKING, SEEKING, AND DRUG-INDUCED REINSTATEMENT IN RATS. THE OBJECTIVE OF THIS APPLICATION IS TO TEST WHETHER TREATMENT WITH A GLP-1R AGONIST CAN REDUCE RELAPSE IN HUMANS WITH AN OPIOID USE DISORDER (OUD). ONE ADVANTAGE OF USING GLP-1R AGONISTS IS THAT VARIOUS FORMULATIONS ALREADY ARE APPROVED FOR TREATMENT OF OBESITY AND TYPE 2 DIABETES [13, 14]. UG3 PHASE AIM G1 WILL CONDUCT A RANDOMIZED, DOUBLE BLIND, PLACEBO-CONTROLLED PILOT STUDY TO DETERMINE WHETHER ONCE DAILY TREATMENT WITH THE SHORTER ACTING GLP-1R AGONIST, LIRAGLUTIDE, CAN SAFELY AND EFFECTIVELY REDUCE CRAVING AND BRAIN RESPONSES TO DRUG CUES AMONG PATIENTS IN RESIDENTIAL TREATMENT FOR AN OUD. UG3 PHASE AIM G2 WILL USE WELL ESTABLISHED ANIMAL MODELS TO TEST THE EFFICACY AND SAFETY OF A MORE RISKY, LONGER-ACTING, BUT MORE EFFICACIOUS, GLP-1R AGONIST, SEMAGLUTIDE, ON HEROIN SEEKING AND CUE/DRUG/STRESS-INDUCED REINSTATEMENT. MILESTONES: (1) DEMONSTRATE SAFETY AND EFFICACY LIRAGLUTIDE AT APPROVED DOSES TO REDUCE CRAVING AND BRAIN RESPONSES TO DRUG CUES AMONG PATIENTS IN RESIDENTIAL TREATMENT FOR OUD WHO ALSO ARE RECEIVING COUNSELING ONLY (CO) OR COUNSELING+BUPRENORPHINE/NALTREXONE (BUP/NA); (2) VERIFY THAT SEMAGLUTIDE IS SAFE AND EFFECTIVE IN REDUCING CUE/DRUG/STRESS-INDUCED HEROIN SEEKING IN AN ANIMAL MODEL. IF THESE MILESTONES ARE MET, UH3 PHASE AIM H1 WILL CONDUCT A TWO-ARM, PSEUDO-RANDOMIZED, PLACEBO CONTROLLED MULTI-SITE CLINICAL TRIAL IN OUTPATIENTS WITH AN OUD TO TEST WHETHER TREATMENT WITH SEMAGLUTIDE VS. PLACEBO WILL REDUCE RELAPSE OUT TO 180 DAYS IN PATIENTS TREATED WITH CO AND COUNSELING+BUP/NA. UH3 PHASE AIM H2 WILL USE ANIMAL MODELS TO FURTHER PROBE THE EFFICACY AND USEFULNESS OF SEMAGLUTIDE TO PREVENT INITIATION OF HEROIN SELF-ADMINISTRATION, TO REDUCE ONGOING HEROIN SELF-ADMINISTRATION, OR TO SERVE AS A NON-OPIOID “BRIDGE TO CARE”, FOR EXAMPLE. IF OUR HYPOTHESES ARE SUPPORTED, WE WILL SHOW THAT TREATMENT WITH GLP-1R AGONISTS CAN SAFELY AND EFFECTIVELY REDUCE OPIOID CRAVING, SEEKING, AND RELAPSE IN RATS AND HUMANS, PROVIDING A SECOND INDICATION FOR FULL MULTI-SITE, PHASE III CLINICAL TRIALS, AND WE WILL LAY THE PRECLINICAL AND CLINICAL GROUNDWORK FOR APPROVAL FROM THE FDA.

PURPOSE: REHABILITATE TAXIWAY. ACTIVITIES TO BE PERFORMED/EXPECTED OUTCOMES: THIS PROJECT REHABILITATES 6,600 FEET OF THE EXISTING TAXIWAY A PAVEMENT THAT REQUIRES REHABILITATION TO ENSURE SAFE AIRFIELD OPERATIONS. THIS GRANT FUNDS THE FOURTH PHASE, WHICH CONSISTS OF 1,320 FEET OF TAXIWAY A PAVEMENT REHABILITATION. THIS MULTI-YEAR GRANT PROVIDES $1,034,437 IN FISCAL YEAR 2023 FUNDING SUBJECT TO FUTURE APPROPRIATIONS. THIS MULTI-YEAR GRANT PROVIDES $7,557,606 IN FISCAL YEAR 2022 FUNDING. INTENDED BENEFICIARY: THIS GRANT WILL PROVIDE FEDERAL FUNDING FOR AIRPORTS ASSOCIATED WITH STATE COLLEGE, PENNSYLVANIA.

IMPROVING TURBINE EFFICIENCIES THROUGH HEAT TRANSFER AND AERODYNAMIC RESEARCH IN THE STEADY THERMAL AERO RESEARCH TURBINE (START)

ILOOK OUT FOR CHILD ABUSE: AN INNOVATIVE LEARNING MODULE FOR CHILDCARE PROVIDERS

LEADING ADVANCED TURBINE RESEARCH FOR HYBRID ELECTRIC PROPULSION SYSTEMS

THE WEAPONS AND PROTECTIVE SYSTEMS TECHNOLOGIES CENTER - A CRIMINAL JUSTICE TECHNOLOGY CENTER OF EXCELLENCE

THE NIH PRECISION BRAIN HEALTH NETWORK: OPEN AND INCLUSIVE MEASUREMENT OF NEUROPSYCHOLOGICAL CHANGE FOR AD/ADRD PRIMARY PREVENTION TRIALS - ACCURATE AND SENSITIVE MEASUREMENT OF NEUROPSYCHOLOGICAL CHANGE IS ESSENTIAL FOR ADVANCING DEMENTIA PREVENTION, ESPECIALLY DURING MIDLIFE WHEN CHANGES RELATED TO ALZHEIMER'S DISEASE AND ALZHEIMER'S DISEASE- RELATED DEMENTIAS (AD/ADRD) BEGIN BUT SYMPTOMS ARE NOT YET EVIDENT. IN RESPONSE TO RFA-AG-25-005, WE PROPOSE TO DEVELOP THE NIH PRECISION BRAIN HEALTH NETWORK (PBHN) TO PROVIDE THE RESEARCH COMMUNITY WITH OPEN, FLEXIBLE, AND USABLE TOOLS TO ENHANCE THE MEASUREMENT OF COGNITIVE CHANGE AND PROMOTE APPLIED BRAIN HEALTH. OUR OBJECTIVES ARE AS FOLLOWS: AIM 1: ESTABLISH AN ORGANIZATIONAL AND GOVERNANCE STRUCTURE THAT PRIORITIZES TRANSPARENCY AND BROAD-BASED SCIENTIFIC COLLABORATION IN DEVELOPING AND VALIDATING MEASURES. THE NETWORK WILL BE ORGANIZED INTO FOUR SCIENTIFIC CORES: DATA, MEASURES, APPLIED VALIDITY, AND DISSEMINATION, EACH CO-LED BY EXPERTS FROM DIFFERENT INSTITUTIONS. AN ADMINISTRATIVE CORE WILL MANAGE OPERATIONS, FINANCIAL OVERSIGHT, AND COMMUNICATION, WITH GOVERNANCE PROVIDED BY A STEERING COMMITTEE. AIM 2: COMPILE, PUBLISH, AND EVALUATE A COMPREHENSIVE INVENTORY OF MEASUREMENT TOOLS FOR AD/ADRD PREVENTION RESEARCH. BY LEVERAGING EXISTING RESOURCES AND INPUT FROM RESEARCHERS AND PRACTITIONERS, WE WILL CREATE A PUBLICLY AVAILABLE INVENTORY THAT WILL BE UPDATED ANNUALLY. TOOLS WILL BE ASSESSED FOR SCALABILITY, OPENNESS, SCIENTIFIC UTILITY, AND SENSITIVITY TO CHANGE ACROSS A RANGE OF STUDY SETTINGS AND CONTEXTS. AIM 3: DEVELOP NEW TOOLS AND COLLECT ADDITIONAL DATA TO ADDRESS UNMET NEEDS. WE WILL ESTABLISH AN INNOVATION PIPELINE SUPPORTING DATA COLLECTION INITIATIVES, PILOT STUDIES, AND MENTORED PROJECTS, WITH A FOCUS ON MEASUREMENT APPROACHES ADAPTABLE TO A VARIETY OF REAL-WORLD SETTINGS. THIS INCLUDES REPURPOSING PROPRIETARY MEASURES FOR OPEN-SOURCE DISTRIBUTION. AIM 4: DISSEMINATE AND IMPLEMENT OPEN MEASUREMENT TOOLS INTO RESEARCH STUDIES THROUGH A PUBLIC-FACING WEBSITE AND THE PBHN OPEN MEASURES TOOLKIT. THIS WEB APPLICATION WILL PROVIDE PLUG-AND-PLAY ASSESSMENTS, DOCUMENTATION, PROTOCOLS, RESOURCES, AND EDUCATIONAL CONTENT, ENSURING USABILITY ACROSS DIFFERENT EXPERTISE LEVELS. FEEDBACK FROM KEY PARTNERS WILL ENHANCE EDUCATIONAL MATERIALS. THE PBHN WILL ESTABLISH FOUNDATIONAL INFRASTRUCTURE TO SUPPORT FUTURE AD/ADRD PRIMARY PREVENTION RESEARCH, FOSTER COLLABORATION, DRIVE MEASUREMENT INNOVATION, AND DEVELOP RELIABLE TOOLS FOR PRECISION MONITORING OF BRAIN HEALTH.

PENN STATE INSTITUTIONAL CAREER DEVELOPMENT CORE

CENTER FOR SELF-ASSEMBLED ORGANIC ELECTRONICS

POPULATION RESEARCH INSTITUTE

TARGETED MATH SCIENCE PARTNERSHIP: MIDDLE GRADES EARTH AND SPACE SCIENCE EDUCATION

(MURI) REDESIGN: RADIATION EFFECTS PREDICTION THROUGH EXPERIMENTALLY VALIDATED SIMULATION OF GALLIUM NITRIDE

TAS::57 3600::TAS "(MURI-12) SMART FUNCTIONAL NANOENERGETIC MATERIALS," DATED 10 NOV 2011

MODEL STATE-SUPPORTED AREA HEALTH EDUCATION CENTERS

CROSS SCALE INTERROGATION OF NPD GENES (SING) IN MICE - ABSTRACT NEURODEVELOPMENTAL AND PSYCHIATRIC DISORDERS (NPDS) ARE HIGHLY PREVALENT AND DEVASTING NEUROLOGICAL CONDITIONS WITHOUT CURE. RECENT GENETIC STUDIES ON NPDS IDENTIFIED HUNDREDS OF HIGH-RISK NPD-RELATED GENES, YET IT REMAINS UNCLEAR HOW THESE GENES INDIVIDUALLY OR COLLECTIVELY AFFECT NEURODEVELOPMENTAL PROCESSES TO CREATE PATHOLOGICAL CONDITIONS IN THE BRAIN. TO IDENTIFY CORE BIOLOGICAL PATHWAYS IMPLICATED IN NPDS, IT IS CRITICAL TO UNDERSTAND HOW THE LOSS OF SPECIFIC NPD GENES LEADS TO CHANGES IN THE MOLECULAR AND CELLULAR LEVEL TO ALTERATION IN NEURAL CIRCUITS, WHICH ULTIMATELY RESULT IN PATHOLOGICAL BEHAVIORAL CHANGES. HERE, WE ASSEMBLE A TEAM OF SEVEN INVESTIGATORS WITH COMPLEMENTARY EXPERTISE TO CREATE AN ASSAY AND DATA GENERATION CENTER (ADGCS) TO COMPREHENSIVELY INVESTIGATE THE IMPACT OF LOSS OF NPD GENES IN MICE. WE AIM TO INVESTIGATE NPD GENES THROUGH CROSS-SCALE INTERROGATION OF NPD GENES (SING), FOCUSING ON GENE EXPRESSION, CELLULAR CHANGES, NEURAL CIRCUITS, AND BEHAVIORS AFFECTED BY 100 NPD GENES IN MICE. UTILIZING KNOCKOUT MOUSE PROJECT (KOMP) RESOURCES, WE WILL EXAMINE THE EFFECT OF NPD GENE DELETION IN MICE ACROSS DEVELOPMENTAL STAGES, EMPLOYING HIGH-THROUGHPUT METHODOLOGIES AND INTEGRATIVE DATA ANALYSIS. FIRST, WE WILL UTILIZE SINGLE-CELL AND SPATIAL TRANSCRIPTOME APPROACHES TO EXAMINE MOLECULAR AND CELLULAR CHANGES. SECOND, WE WILL DEPLOY MRI AND HIGH-RESOLUTION 3D MAPPING METHODS TO EXAMINE ALTERED NEURAL CIRCUIT CONNECTIVITY AND BRAIN ANATOMY. THIRD, WE WILL EMPLOY A HIGH THROUGHPUT HOME CAGE SYSTEM TO AUTOMATICALLY TRACK ALTERED BEHAVIOR. MOREOVER, WE WILL PERFORM A PILOT STUDY TO DEVELOP CRISPR BASED VIRAL APPROACHES TO RAPIDLY KNOCKOUT TARGET GENES IN DEVELOPING MICE AND TO EXAMINE ALTERED NEURAL CIRCUIT MATURATION PATTERNS. WE PLAN TO INTEGRATE MULTISCALE DATA AND PERFORM MACHINE LEARNING-BASED ANALYSES TO IDENTIFY SHARED BIOLOGICAL PATHWAYS FOR SPECIFIC NPDS, AND BROADLY DISSEMINATE THE DATA FOR PUBLIC ACCESS. WE EXPECT TO GENERATE CRITICAL EXPERIMENTAL DATA AT AN UNPRECEDENTED SCALE, TO RAPIDLY ADVANCE OUR UNDERSTANDING OF KEY BIOLOGICAL PATHWAYS OF NPDS, WHICH WILL INFORM FUTURE THERAPEUTIC APPROACHES.

THE AMBORELLA GENOME: A REFERENCE FOR PLANT BIOLOGY

THE PURPOSE OF THIS AGREEMENT IS TO FUND RESEARCH SUPPORTING THE DEFENSE ADVANCED RESEARCH PROJECTS AGENCY DARPA INFORMATION INNOVATION OFFICE I2O. THIS EFFORT SHALL BE CARRIED OUT GENERALLY AS SET FORTH IN EXHIBIT B, RESEARCH DESCRIPTION DOCUMENT, AND IN THE RECIPIENTS PROPOSAL TITLED, VERIPRO VERIFIED PROBABILISTIC COGNITIVE REASONING FOR TACTICAL MIXED REALITY SYSTEMS DATED 20 DECEMBER 2023, COPIES OF WHICH ARE IN THE POSSESSION OF BOTH PARTIES.

VERTICAL LIFT RESEARCH CENTER OF EXCELLENCE - PENN STATE UNIVERSITY

THE SPOTTED LANTERNFLY (SLF), LYCORMA DELICATULA, HAS EMERGED AS AN INVASIVE PEST OF CRITICAL IMPORTANCE TO SPECIALTY CROPS INCLUDING TREE FRUIT AND GRAPES WITH THE POTENTIAL TO AFFECT MANY OTHERS. WHILE WE NOW KNOW THAT SLF INCURS IMMEDIATE, ACUTE DAMAGE TO GRAPES, THE POTENTIAL FOR SLF TO EXERT ACUTE AND/OR CHRONIC DAMAGE UPON OTHER SPECIALTY CROPS IS NOT YET CLEAR, BUT POTENTIAL LONG-TERM IMPACT OF SLF IN THE USA COULD BE STAGGERING. IN STATES WHERE SLF HAS BEEN ESTABLISHED OR HAS BEEN DETECTED, SLF THREATENS $802 MILLION IN TREE FRUIT, $113 MILLION IN GRAPE, $110 MILLION IN SMALL FRUIT, AND $2.6 BILLION IN ORNAMENTALS; NATIONWIDE THESE NUMBERS GROW TO OVER $18 BILLION. SLF LAYS INCONSPICUOUS EGG MASSES ON SMOOTH SURFACES INCLUDING TREE BARK, AUTOMOBILES, RAIL CARS, AND SHIPPING PALLETS, PORTENDING ABRUPT, DISTANT SPREAD.THROUGH OUR ROBUST REGIONAL COLLABORATION AS A TEAM OF RESEARCHERS AND EXTENSION PERSONNEL, WE WILL RAPIDLY DEVELOP TACTICS TO MITIGATE INJURY TO VULNERABLE SPECIALTY CROPS IN THE SHORT-TERM. BASED ON AN EXTENSIVE ARRAY OF LAB AND FIELD BASED EXPERIMENTS, WE WILL ALSO EXPAND OUR KNOWLEDGE OF SLF BIOLOGY, ECOLOGY, BEHAVIOR AND BIOLOGICAL CONTROL TACTICS TO ENABLE SUSTAINABLE MANAGEMENT, NOT ONLY DIRECTLY ALLEVIATING THE THREAT TO SPECIALTY CROP PRODUCERS, BUT ALSO INDIRECTLY BENEFITTING THE MANY OTHER SLF-AFFECTED STAKEHOLDER GROUPS THAT ARE ENDURING PERVASIVE AND INCREASING PROBLEMS. WE WILL DELIVER MANAGEMENT STRATEGIES AND NEW KNOWLEDGE TO SPECIALTY CROP STAKEHOLDERS AND THE GENERAL PUBLIC VIA SYNERGIZED AND INNOVATIVE EXTENSION PROGRAMMING PRODUCED BY PARTNERING UNIVERSITIES, USDA, AND NEIPMC. WE WILL PROVIDE SLF EDUCATION AND OUTREACH OPPORTUNITIES USING TRADITIONAL AND WEB-BASED PLATFORMS. WE WILL DEVELOP AND IMPLEMENT EVALUATION PLANS TO DIRECT RESEARCH PLANS AND ASSESS EFFICACY, INCLUDING ECONOMIC EVALUATION, OF PROJECT OUTPUTS AND MANAGEMENT RECOMMENDATIONS. WE WILL TRAIN THE NEXT GENERATION OF SCIENTISTS AND EXTENSION EDUCATORS TO BE BETTER PREPARED FOR INVASIVE PESTS USING CROSS-TRAINING AND LAB ROTATIONS TO PROMOTE CROSS-INSTITUTIONAL COLLABORATIONS AND ENHANCE COORDINATION OF EXTENSION AND RESEARCH ACTIVITIES. WE WILL HOLD STAKEHOLDER ADVISORY PANEL MEETINGS TO EVALUATE ACCOMPLISHMENTS, DIRECT AND PRIORITIZE FUTURE RESEARCH PLANS, AND GUIDE EXTENSION OBJECTIVES.THROUGH THESE EFFORTS WE SEEK TO ULTIMATELY DEVELOP AND COMMUNICATE EFFICACIOUS TACTICS FOR MANAGING THE INVASIVE SPOTTED LANTERNFLY ON VULNERABLE SPECIALTY CROPS TO REDUCE THE RISK OF WIDESPREAD, CATASTROPHIC DAMAGE AND TO DEVELOP STRATEGIES FOR LONG-TERM SLF MANAGEMENT.

**AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** OUR LONG-TERM GOAL IS TO TRANSITION THE MANAGEMENT OF MUSHROOM PATHOGENS AND FLIES, BEYOND SHORT-TERM RELIANCE ON PESTICIDES THAT ARE RAPIDLY AND REPEATEDLY LOST DUE TO RESISTANCE AND REGULATORY PROCESSES. INTEGRATE DISEASE MANAGEMENT TOOLS, TECHNIQUES, AND DIAGNOSTICS, WITH PATHOGEN BIOLOGY. INCREASE AWARENESS AND IMPLEMENTATION OF NOVEL AND EFFECTIVE IPM SOLUTIONS BY MUSHROOM GROWERS AND IMPROVE COMMUNITY RELATIONS. A PREVIOUS SUITE OF APPLICATIONS WAS DEVELOPED, CALLED CROPSMARTS, USED FOR WEB AND MOBILE CROP OPERATIONS MONITORING AND DATA COLLECTION/ANALYSIS. WITH THIS PROPOSED EXTENSION TO THAT WORK, WE WILL CONTINUE THE CYCLE OF DESIGN-DEVELOPMENT-TEST WORKING WITH COMMERCIAL MUSHROOM FARMS. DEVELOP AND FACILITATE THE ADOPTION OF EFFECTIVE IPM STRATEGIES TO MANAGE MUSHROOM FLIES ON FARMS. DEVELOP BILINGUAL EDUCATIONAL MATERIALS FOR MUSHROOM PRODUCERS AND EMPLOYEES FOR THE MANAGEMENT OF MUSHROOM FLIES AND DISEASES. EVALUATE NATURAL AND MUSHROOM-DERIVED COMPOUNDS TO INHIBIT GROWTHOR DISRUPT VIRULENCE MECHANISMS OF BLOTCH AND FUNGAL PATHOGENS AND FLIES. CONFIRM THE THERMAL DEATH POINTS OF SEVERAL MUSHROOM PATHOGENS IN CULTURE AND THEN USING AN EXTENSIVE ARRAY OF REMOTE THERMOMETERS, WE WILL MONITOR POST-CROP STEAMING PROCEDURES ON MUSHROOM FARMS TO CONFIRM THE EFFICIENCY OF THEIR PROCESS. RE-INVESTIGATE THE VIRUS SYMPTOMS ON NEW HYBRID STRAINS THAT DEVELOP UNDER DIFFERENT SPORE LOADS AND TIMES OF INFECTION. VALIDATION OF VIRUS TESTING PROTOCOLS FOR DIAGNOSTICS AND IMPROVEMENTS TO DIFFERENTIATE AND DETECT VARIOUS VIRUS DISEASES.

PHOSPHATE ACTIVATION MECHANISMS

3D CAM: DERIVING AND VALIDATING A 3 MINUTE DIAGNOSTIC ASSESSMENT FOR DELIRIUM

THE PENNSYLVANIA STATE UNIVERSITY: NEW ROOTS AWARD. CONTROL NUMBER: 1565-1529 TITLE: DEEPER: AN INTEGRATED PHENOTYPING PLATFORM FOR DEEPER ROOTS

PREVENTING OBESITY THROUGH INTERVENTION DURING INFANCY

UNIVERSITY TRANSPORTATION CENTER

VERTICAL LIFT RESEARCH CENTER OF EXCELLENCE

MECHANISMS OF DESMOSOME REGULATION AND DISASSEMBLY IN THE SKIN DISEASE PEMPHIGUS

STUDY OF ANTI-MALARIALS IN INCOMPLETE LUPUS ERYTHEMATOSUS (SMILE)

VERTICAL LIFT RESEARCH CENTER OF EXCELLENCE

PIPELINE: PENNSTATE INTERN PIPELINE LINKS TO NAVY ENGINEERING

A UNIFIED MULTISCALE APPROACH FOR NANO ENGINEERED ENERGETIC MATERIALS

13/24 THE HEALTHY BRAIN AND CHILD DEVELOPMENT NATIONAL CONSORTIUM - PROJECT SUMMARY/ABSTRACT NEURODEVELOPMENTAL PROCESSES ARE SHAPED BY DYNAMIC INTERACTIONS BETWEEN GENES AND ENVIRONMENTS. MALADAPTIVE EXPERIENCES EARLY IN LIFE CAN ALTER DEVELOPMENTAL TRAJECTORIES, LEADING TO HARMFUL AND ENDURING DEVELOPMENTAL SEQUELAE. PRE- AND POSTNATAL HAZARDS INCLUDE MATERNAL SUBSTANCE EXPOSURE, TOXICANT EXPOSURES IN PREGNANCY AND EARLY LIFE, MATERNAL HEALTH CONDITIONS, PARENTAL PSYCHOPATHOLOGY, MALTREATMENT, STRUCTURAL RACISM, AND EXCESSIVE STRESS. TO ELUCIDATE HOW VARIOUS ENVIRONMENTAL HAZARDS IMPACT CHILD DEVELOPMENT, IT IS IMPERATIVE THAT A NORMATIVE TEMPLATE OF DEVELOPMENTAL TRAJECTORIES OVER THE FIRST 10 YEARS OF LIFE BE ESTABLISHED BASED ON A SUFFICIENTLY LARGE AND DEMOGRAPHICALLY DIVERSE SAMPLE OF THE US POPULATION. TO ACCOMPLISH THIS, THE HEALTHY BRAIN AND CHILD DEVELOPMENT NATIONAL CONSORTIUM (HBCD-NC) HAS BEEN FORMED TO DEPLOY A HARMONIZED, OPTIMIZED, AND INNOVATIVE SET OF NEUROIMAGING (MRI, EEG) MEASURES COMPLEMENTED BY AN EXTENSIVE BATTERY OF BEHAVIORAL, PHYSIOLOGICAL, AND PSYCHOLOGICAL TOOLS, AND BIOSPECIMENS TO UNDERSTAND NEURODEVELOPMENTAL TRAJECTORIES IN A SAMPLE OF 7,500 MOTHERS AND INFANTS ENROLLED AT 24 SITES ACROSS THE UNITED STATES (US). THE HBCD-NC WILL CARRY OUT A COMMON RESEARCH PROTOCOL UNDER DIRECTION OF THE HBCD-NC ADMINISTRATIVE CORE (HCAC) AND WILL ASSEMBLE AND DISTRIBUTE A COMPREHENSIVE AND WELL-CURATED RESEARCH DATASET TO THE SCIENTIFIC COMMUNITY AT LARGE UNDER THE DIRECTION OF THE HBCD-NC DATA COORDINATING CENTER (HDCC). THE OVERARCHING GOAL OF THE HBCD-NC IS TO CREATE A COMPREHENSIVE, HARMONIZED, AND HIGH- DIMENSIONAL DATASET THAT WILL CHARACTERIZE TYPICAL NEURODEVELOPMENTAL TRAJECTORIES IN US CHILDREN AND THAT WILL ASSESS HOW BIOLOGICAL AND ENVIRONMENTAL EXPOSURES AFFECT THOSE TRAJECTORIES. A SPECIAL EMPHASIS WILL BE PLACED ON UNDERSTANDING THE IMPACT OF PRE- AND POSTNATAL EXPOSURE TO OPIOIDS, MARIJUANA, ALCOHOL, TOBACCO AND/OR OTHER SUBSTANCES. TO ADDRESS THESE BROAD OBJECTIVES, THE SAMPLE OF WOMEN ENROLLED WILL INCLUDE: 1) A RACIALLY, ETHNICALLY, AND SOCIOECONOMICALLY DIVERSE COHORT THAT IS REPRESENTATIVE OF THE US POPULATION; 2) PREGNANT WOMAN WITH USE OF TARGETED SUBSTANCES (OPIOIDS, MARIJUANA, ALCOHOL, TOBACCO); AND 3) DEMOGRAPHICALLY AND BEHAVIORALLY SIMILAR WOMEN WITHOUT SUBSTANCE USE IN PREGNANCY TO ENABLE VALID CAUSAL INFERENCES. IN ADDITION, THE HBCD-NC WILL IDENTIFY KEY DEVELOPMENTAL WINDOWS DURING WHICH BOTH HARMFUL AND PROTECTIVE ENVIRONMENTS HAVE THE MOST INFLUENCE ON LATER NEURODEVELOPMENTAL OUTCOMES. THE LARGE, MULTI-MODAL, LONGITUDINAL, AND GENERALIZABLE DATASET THAT WILL BE PRODUCED FOR THE FIRST TIME BY THIS STUDY WILL PROVIDE NOVEL INSIGHTS INTO CHILD DEVELOPMENT USING STATE- OF-THE-ART METHODS. THE HBCD-NC STUDY WILL INFORM PUBLIC POLICY TO IMPROVE THE HEALTH AND DEVELOPMENT OF CHILDREN ACROSS THE NATION.

MICROELECTRONICS AND NANOMANUFACTURING PARTNERSHIP FOR VETERANS -THE UNITED STATES (U.S.) HAS BEEN EXPERIENCING A SEMICONDUCTOR CHIP SHORTAGE DUE IN PART TO THE PANDEMIC. THIS SHORTAGE HAS IMPACTED BUSINESSES AND INDUSTRY, INCLUDING AUTOMOTIVE, CONSUMER ELECTRONICS, DATA SCIENCE, AND CYBERSECURITY TO NAME A FEW. EFFORTS ARE UNDERWAY TO SUPPORT SEMICONDUCTOR AND MICROELECTRONICS TECHNOLOGIES IN THE U.S., WHICH WILL REQUIRE A PREPARED AND DIVERSE SKILLED TECHNICAL WORKFORCE TO SUPPORT THESE CRITICAL ECONOMIC ENGINES. A STRONG NANOMANUFACTURING WORKFORCE WILL ENABLE THE U.S. TO BE COMPETITIVE IN THE GLOBAL ECONOMY AND WILL SUPPORT THE U.S. LEADERSHIP IN MICROELECTRONICS AND SEMICONDUCTOR TECHNOLOGIES. THIS PROJECT LED BY THE CENTER FOR NANOTECHNOLOGY EDUCATION AND UTILIZATION AT PENNSYLVANIA STATE UNIVERSITY WILL SUPPORT MEMBERS OF THE U.S. MILITARY, VETERANS, AND FAMILY MEMBERS TO GAIN THE KNOWLEDGE, SKILLS, AND ABILITIES (KSAS) TO MOVE INTO THE SEMICONDUCTOR AND MICROELECTRONICS WORKFORCE. MANY OF THESE INDIVIDUALS HAVE RELEVANT EXPERIENCE WITH MILITARY TECHNOLOGY AS MEMBERS OF TEAMS RESPONSIBLE FOR BUILDING MECHANICAL, ELECTRICAL AND COMMUNICATION SYSTEMS. VETERANS WITHOUT DIRECT MILITARY TECHNOLOGY EXPERIENCES ALSO HAVE SKILLS SUCH AS TEAMWORK AND PROJECT MANAGEMENT SKILLS THAT INDUSTRY RECOGNIZES AS NEEDED SKILLS WITHIN THEIR WORKFORCE. THIS PROJECT WILL PROVIDE EDUCATIONAL OPPORTUNITIES FOR MILITARY PERSONNEL, VETERANS, AND FAMILY MEMBERS TO GAIN THE KSAS NEEDED TO ENTER THE NANOMANUFACTURING WORKFORCE. MEMBERS OF THE COLLABORATIVE INCLUDE 2-YR AND 4-YR INSTITUTIONS, MICROELECTRONICS COMPANIES, AND THE GLOBAL SEMI TRADE ASSOCIATION. THE PROJECT WILL LEVERAGE A SUCCESSFUL PILOT THAT INVOLVED THE U.S. NAVY, TIDEWATER COMMUNITY COLLEGE AND NORFOLK STATE UNIVERSITY, WHICH WILL BE ADAPTED AND SCALED TO INVOLVE ADDITIONAL ACADEMIC INSTITUTIONS AND BRANCHES OF THE MILITARY. THE PROJECT WILL: (1) ADAPT AND IMPLEMENT THE CONTENT OF THE PILOT AND OFFER A MICROELECTRONICS AND NANOMANUFACTURING CERTIFICATE PROGRAM (MNP) SUPPORTED BY COMMUNITY AND TECHNICAL COLLEGES AND UNIVERSITIES, (2) CONTINUALLY ASSESS AND ADJUST THE CONTENT IN CONSULTATION WITH INDUSTRY FOR SKILLSET NEEDS, (3) WORK TO SECURE THE ENDORSEMENT OF THE MNP BY DEPARTMENTS OF VETERAN SERVICES FOR DIFFERENT MILITARY BRANCHES, AND (4) ELEVATE THE ROLE OF COMMUNITY AND TECHNICAL COLLEGE FACULTY IN THE DELIVERY OF THE MNP MINIMIZING THE DEPENDENCE ON THE RESEARCH UNIVERSITIES. THIS PROJECT IS FUNDED BY THE ADVANCED TECHNOLOGICAL EDUCATION PROGRAM THAT FOCUSES ON THE EDUCATION OF TECHNICIANS FOR THE ADVANCED-TECHNOLOGY FIELDS THAT DRIVE THE NATION'S ECONOMY. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

AN IN INTEGRATED PLATFORM FOR MULTIOMIC ANALYSES OF PATHOGEN AND HOST DATA USING SCALABLE PUBLIC INFRASTRUCTURE - PROJECT SUMMARY DATA IS THE PRIMARY CURRENCY FOR ALL DOMAINS OF TODAY'S BIOMEDICAL RESEARCH. HOWEVER, DATA DOES NOT HAVE SOME OF THE PROPERTIES OF A GOOD CURRENCY: DURABILITY, PORTABILITY, UNIFORMITY, CONVERTIBILITY, AND ACCEPTABILITY. IT IS VAST, HETEROGENEOUS, GEOGRAPHICALLY DISTRIBUTED, AND OFTEN PROTECTED BY ACCESS CONTROL MECHANISMS. IT REQUIRES HARDWARE AND SOFTWARE COMPLEX MACHINERY TO PROCESS. SKILLS NEEDED FOR DATA INTERPRETATION ARE SPARSE ACROSS THE ENTIRE BIOMEDICAL DOMAIN. HOW DOES ONE MAKE SUCH A CURRENCY UNIVERSALLY BENEFICIAL TO ALL INFECTIOUS DISEASE RESEARCHERS WHO STUDY DIFFERENT ORGANISMS WITH DISPARATE GOALS, MOTIVATIONS, AND EXPERTISE? THIS BRINGS US DIRECTLY TO THE MAIN POINT OF THIS PROPOSAL: TO IMPLEMENT A COMMON DATA ANALYSIS MEDIUM—BRC.ANALYTICS—THAT WOULD CONNECT INFECTIOUS DISEASE RESEARCHERS TO DATA, TOOLS, AND WORKFLOWS. THE TRANSFORMATIVE TENETS OF THE PROPOSED SYSTEM ARE: (1) GIVING ACCESS TO AN ENSEMBLE OF DATA RESOURCES VIA A SINGLE WORKSPACE WHERE DATA CAN BE STORED, COMBINED, AND ANALYZED; (2) ENABLING ACCESS TO THE MAJORITY OF HIGH QUALITY OPEN SOURCE TOOLS AND ALLOW CREATION OF COMPLEX WORKFLOWS IN THE WORKSPACE; (3) ENSURING THAT WORKSPACE IN POWERED BY POWERFUL HARDWARE CAPABLE OF SUSTAINING THOUSANDS OF USERS ANALYZING LARGE DATASETS; (4) PROVIDING SEVERAL MODES OF ACCESS INCLUDING A GRAPHICAL USER INTERFACE (GUI) AS WELL AS AN APPLICATION PROGRAMMING INTERFACE (API). BRC.ANALYTICS IS A UNIQUE KNOWLEDGEBASE THAT PROVIDES DATA, TOOLS, AND INFRASTRUCTURE AS WELL AS THE KNOW-HOW” ON HOW TO APPLY THIS POWER EFFECTIVELY.

ENGINEERING OF SENSOR NETWORK STRUCTURE FOR DEPENDABLE FUSION

USING THE SUSQUEHANNA - SHALE HILLS CZO TO PROJECT FROM THE GEOLOGICAL PAST TO THE ANTHROPOCENE FUTURE

GROUNDWORK FOR A SYNCHROTRON MICROCT IMAGING RESOURCE FOR BIOLOGY (SMIRB)

EARLY INTERVENTION TO PREVENT STUDENT BINGE DRINKING

THE COLLEGE OF AGRICULTURAL SCIENCES AT PENN STATE WILL PROVIDE COMPREHENSIVE SUPPORT TO THE RESIDENTS OF PENNSYLVANIA THROUGH THE A CTIVITIES OF THE PENNSYLVANIA AGRICULTURAL EXPERIMENT STATION (AES) AND PENN STATE EXTENSION (EXTENSION). WE WILL BE RESPONSIVE TO STAKEHOLDER NEEDS THROUGH TRANSLATIONAL RESEARCH AND DELIVERY OF SCIENCE-BASED PROGRAMS TO CLIENTELE, BUT WE WILL ALSO CONDUCT REGION ALLY, NATIONALLY, AND INTERNATIONALLY RELEVANT FUNDAMENTAL RESEARCH THAT GENERATES BASELINE DATA TO SOLVE FUTURE NEEDS RELATIVE TO AGRICULTURE AND NATURAL RESOURCES AND ACTIVELY SEEK NEW AND BETTER WAYS TO COMMUNICATE OUR PROGRAMS TO NEW AUDIENCES. OUR FACULTY AND STAFF, SUPPORTED BY FEDERAL BASE FUNDING (TO INCLUDE HATCH AND MULTISTATE HATCH FUNDS), WILL EFFECTIVELY LEVERAGE THIS INVESTMENT AGAINST MANY OTHER EXTERNAL FUNDING SOURCES TO CONDUCT PROGRAMS OF THE HIGHEST CALIBER. WE ARE COMMITTED TO EXCELLENCE IN RESEARCH, EDUCATING THE NEXT GENERATION OF AGRICULTURAL PROFESSIONALS AND CITIZENS,AND PROMOTING LIFE-LONG LEARNING AMONG THE CITIZENS OF PENNSYLVANIA AND WITHIN THE REGION AND NATION. OUR MISSION IS CLEAR: "THE MISSION OF THE COLLEGE OF AGRICULTURAL SCIENCES IS TO DISCOVER, INTEGRATE, TRANSLATE, AND DISSEMINATE KNOWLEDGE TO ENHANCE THE FOOD AND AGRICULTURAL SYSTEM, NATURAL RESOURCES AND ENVIRONMENTAL STEWARDSHIP, AND ECONOMIC AND SOCIAL WELL-BEING, THEREBY IMPROVING THE LIVES OF PEOPLE IN PENNSYLVANIA, THE NATION, AND THE WORLD." EVOLVING OUTLOOK ON THE FUTURE OF AGRICULTURE AGRICULTURE FACES CHALLENGES OF RISING ENERGY COSTS, WEATHER EXTREMES, AN EXPANDING HUMAN POPULATION, ENVIRONMENTAL DEGRADATION, LOSS OF BIODIVERSITY, LABOR SHORTAGES, ARMED CONFLICT, AND A LINGERING PANDEMIC. TO HELP MEET THESE CHALLENGES, WE ARE DEVELOPING A CONCEPTUAL FRAMEWORK BASED ON THE SCIENCE OF AGRICULTURAL SUSTAINABILITY--DEFINED AS THE INTEGRATION OF NATURAL AND SOCIAL SCIENCES TO INFORM PRACTICE AND POLICY FOR PRODUCTIVE, WORKING LANDSCAPES, HEALTHY WATERSHEDS, AND RESILIENT ECONOMIES. THIS INNOVATIVE APPROACH TO AGRICULTURAL RESEARCH, ENGAGEMENT, AND EDUCATION CENTERS ON THE IMPACTS AND SYNERGIES OF CONTIGUOUS RURAL AND URBAN LANDSCAPES. THIS MOSAIC OF DENSELY POPULATED AREAS NEXT TO FORESTS AND AGRICULTURAL LANDSCAPES IS UNIQUE TO PENNSYLVANIA AND THE MID-ATLANTIC REGION AND REQUIRES AN INTEGRATED STRATEGY TO ACHIEVE HEALTHY AND THRIVING AGRICULTURE, NATURAL SYSTEMS, ECONOMIES, AND COMMUNITIES. A PRIMARY COMPONENT OF AES AND EXTENSION WORK IN OUR COLLEGE WILL BE BUILT ON THE THREE INTEGRATED PILLARS OF INTENSIFICATION, RESILIENCE, AND REGENERATION OF AGRICULTURAL LANDSCAPES AS SOLUTIONS TO SOME OF THE MOST VEXING PROBLEMS CONFRONTING PENNSYLVANIA AND SIMILAR MOSAIC LANDSCAPES WORLDWIDE. WE WILL HOLISTICALLY AND COMPREHENSIVELY ADDRESS THESE CRITICAL ISSUES: -INCREASING THE EFFICIENCY AND PROFITABILITY OF AGRICULTURAL PRODUCTION WHILE MINIMIZING ENVIRONMENTAL IMPACTS AND IMPROVE HUMAN HEALTH -EQUIPPING FARMERS TO ABSORB AND RECOVER FROM SHORT-TERM EMERGENCIES AND/OR LONG-TERM STRESSES TO THEIR AGRICULTURAL PRODUCTION AND LIVELIHOODS -OPTIMIZING PLANTS, ANIMALS, AND ECOSYSTEMS FOR RESILIENCE TO AND/OR FASTER RECOVERY FROM ENVIRONMENTALLY RELATED STRESSES -DEVELOPING STRATEGIES FOR BETTER MANAGEMENT OF NUTRIENT INPUTS AND OUTPUTS ACROSS COMPLEX AGRICULTURAL AND NATURAL RESOURCE SYSTEMS, FROM LOCAL FIELDS AND FARMS TO LARGE WATERSHEDS -HARNESSING SPATIAL DATA AND REMOTE SENSING TECHNOLOGIES TO MAP AND MODEL .PREDICTIVE SIMULATIONS OF ENVIRONMENTAL CHANGE

HATCH ACT FORMULA FUNDING FOR AGRICULTURAL RESEARCH ACTIVITIES

THE COLLEGE OF AGRICULTURAL SCIENCES AT PENN STATE WILL PROVIDE COMPREHENSIVE SUPPORT TO THE RESIDENTS OF PENNSYLVANIA THROUGH THE A CTIVITIES OF THE PENNSYLVANIA AGRICULTURAL EXPERIMENT STATION (AES) AND PENN STATE EXTENSION (EXTENSION). WE WILL BE RESPONSIVE TO STAKEHOLDER NEEDS THROUGH TRANSLATIONAL RESEARCH AND DELIVERY OF SCIENCE-BASED PROGRAMS TO CLIENTELE, BUT WE WILL ALSO CONDUCT REGION ALLY, NATIONALLY, AND INTERNATIONALLY RELEVANT FUNDAMENTAL RESEARCH THAT GENERATES BASELINE DATA TO SOLVE FUTURE NEEDS RELATIVE TO AGRICULTURE AND NATURAL RESOURCES AND ACTIVELY SEEK NEW AND BETTER WAYS TO COMMUNICATE OUR PROGRAMS TO NEW AUDIENCES. OUR FACULTY AND STAFF, SUPPORTED BY FEDERAL BASE FUNDING (TO INCLUDE HATCH AND MULTISTATE HATCH FUNDS), WILL EFFECTIVELY LEVERAGE THIS INVESTMENT AGAINST MANY OTHER EXTERNAL FUNDING SOURCES TO CONDUCT PROGRAMS OF THE HIGHEST CALIBER. WE ARE COMMITTED TO EXCELLENCE IN RESEARCH, EDUCATING THE NEXT GENERATION OF AGRICULTURAL PROFESSIONALS AND CITIZENS, AND PROMOTING LIFE-LONG LEARNING AMONG THE CITIZENS OF PENNSYLVANIA AND WITHIN THE REGION AND NATION. OUR MISSION IS CLEAR: THE MISSION OF THE COLLEGE OF AGRICULTURAL SCIENCES IS TO DISCOVER, INTEGRATE, TRANSLATE, AND DISSEMINATE KNOWLEDGE TO ENHANCE THE FOOD AND AGRICULTURAL SYSTEM, NATURAL RESOURCES AND ENVIRONMENTAL STEWARDSHIP, AND ECONOMIC AND SOCIAL WELLBEING, THEREBY IMPROVING THE LIVES OF PEOPLE IN PENNSYLVANIA, THE NATION, AND THE WORLD. AGRICULTURE FACES CHALLENGES OF RISING ENERGY COSTS, WEATHER EXTREMES, AN EXPANDING HUMAN POPULATION, ENVIRONMENTAL DEGRADATION, LOSS OF BIODIVERSITY, LABOR SHORTAGES, ARMED CONFLICT, AND A LINGERING PANDEMIC. TO HELP MEET THESE CHALLENGES, WE ARE DEVELOPING A CONCEPTUAL FRAMEWORK BASED ON THE SCIENCE OF AGRICULTURAL SUSTAINABILITY, DEFINED AS THE INTEGRATION OF NATURAL AND SOCIAL SCIENCES TO INFORM PRACTICE AND POLICY FOR PRODUCTIVE, WORKING LANDSCAPES, HEALTHY WATERSHEDS, AND RESILIENT ECONOMIES. THIS INNOVATIVE APPROACH TO AGRICULTURAL RESEARCH, ENGAGEMENT, AND EDUCATION CENTERS ON THE IMPACTS AND SYNERGIES OF CONTIGUOUS RURAL AND URBAN LANDSCAPES. THIS MOSAIC OF DENSELY POPULATED AREAS NEXT TO FORESTS AND AGRICULTURAL LANDSCAPES IS UNIQUE TO PENNSYLVANIA AND THE MID-ATLANTIC REGION AND REQUIRES AN INTEGRATED STRATEGY TO ACHIEVE HEALTHY AND THRIVING AGRICULTURE, NATURAL SYSTEMS, ECONOMIES, AND COMMUNITIES. A PRIMARY COMPONENT OF AES AND EXTENSION WORK IN OUR COLLEGE WILL BE BUILT ON THE THREE INTEGRATED PILLARS OF INTENSIFICATION, RESILIENCE, AND REGENERATION OF AGRICULTURAL LANDSCAPES AS SOLUTIONS TO SOME OF THE MOST VEXING PROBLEMS CONFRONTING PENNSYLVANIA AND SIMILAR MOSAIC LANDSCAPES WORLDWIDE. WE WILL HOLISTICALLY AND COMPREHENSIVELY ADDRESS THESE CRITICAL ISSUES: INCREASING THE EFFICIENCY AND PROFITABILITY OF AGRICULTURAL PRODUCTION WHILE MINIMIZING ENVIRONMENTAL IMPACTS AND IMPROVE HUMAN HEALTH, EQUIPPING FARMERS TO ABSORB AND RECOVER FROM SHORT-TERM EMERGENCIES AND LONG-TERM STRESSES TO THEIR AGRICULTURAL PRODUCTION AND LIVELIHOODS, OPTIMIZING PLANTS, ANIMALS, AND ECOSYSTEMS FOR RESILIENCE TO AND FASTER RECOVERY FROM ENVIRONMENTALLY RELATED STRESSES, DEVELOPING STRATEGIES FOR BETTER MANAGEMENT OF NUTRIENT INPUTS AND OUTPUTS ACROSS COMPLEX AGRICULTURAL AND NATURAL RESOURCE SYSTEMS, FROM LOCAL FIELDS AND FARMS TO LARGE WATERSHEDS, HARNESSING SPATIAL DATA AND REMOTE SENSING TECHNOLOGIES TO MAP AND MODEL PREDICTIVE SIMULATIONS OF ENVIRONMENTAL CHANGE.

HATCH ACT FORMULA FUNDING FOR AGRICULTURAL RESEARCH ACTIVITIES

HATCH ACT FORMULA FUNDING FOR AGRICULTURAL RESEARCH ACTIVITIES

THE COLLEGE OF AGRICULTURAL SCIENCES AT PENN STATE WILL PROVIDE COMPREHENSIVE SUPPORT TO THE RESIDENTS OF PENNSYLVANIA THROUGH THE A CTIVITIES OF THE PENNSYLVANIA AGRICULTURAL EXPERIMENT STATION (AES) AND PENN STATE EXTENSION (EXTENSION). WE WILL BE RESPONSIVE TO STAKEHOLDER NEEDS THROUGH TRANSLATIONAL RESEARCH AND DELIVERY OF SCIENCE-BASED PROGRAMS TO CLIENTELE, BUT WE WILL ALSO CONDUCT REGION ALLY, NATIONALLY, AND INTERNATIONALLY RELEVANT FUNDAMENTAL RESEARCH THAT GENERATES BASELINE DATA TO SOLVE FUTURE NEEDS RELATIVE TO AGRICULTURE AND NATURAL RESOURCES AND ACTIVELY SEEK NEW AND BETTER WAYS TO COMMUNICATE OUR PROGRAMS TO NEW AUDIENCES. OUR FACULTY AND STAFF, SUPPORTED BY FEDERAL BASE FUNDING (TO INCLUDE HATCH AND MULTISTATE HATCH FUNDS), WILL EFFECTIVELY LEVERAGE THIS INVESTMENT AGAINST MANY OTHER EXTERNAL FUNDING SOURCES TO CONDUCT PROGRAMS OF THE HIGHEST CALIBER. WE ARE COMMITTED TO EXCELLENCE IN RESEARCH, EDUCATING THE NEXT GENERATION OF AGRICULTURAL PROFESSIONALS AND CITIZENS, AND PROMOTING LIFE-LONG LEARNING AMONG THE CITIZENS OF PENNSYLVANIA AND WITHIN THE REGION AND NATION. OUR MISSION IS CLEAR: 'THE MISSION OF THE COLLEGE OF AGRICULTURAL SCIENCES IS TO DISCOVER, INTEGRATE, TRANSLATE, AND DISSEMINATE KNOWLEDGE TO ENHANCE THE FOOD AND AGRICULTURAL SYSTEM, NATURAL RESOURCES AND ENVIRONMENTAL STEWARDSHIP, AND ECONOMIC AND SOCIAL WELLBEING, THEREBY IMPROVING THE LIVES OF PEOPLE IN PENNSYLVANIA, THE NATION, AND THE WORLD.' AGRICULTURE FACES CHALLENGES OF RISING ENERGY COSTS, WEATHER EXTREMES, AN EXPANDING HUMAN POPULATION, ENVIRONMENTAL DEGRADATION, LOSS OF BIODIVERSITY, LABOR SHORTAGES, ARMED CONFLICT, AND A LINGERING PANDEMIC. TO HELP MEET THESE CHALLENGES, WE ARE DEVELOPING A CONCEPTUAL FRAMEWORK BASED ON THE SCIENCE OF AGRICULTURAL SUSTAINABILITY, DEFINED AS THE INTEGRATION OF NATURAL AND SOCIAL SCIENCES TO INFORM PRACTICE AND POLICY FOR PRODUCTIVE, WORKING LANDSCAPES, HEALTHY WATERSHEDS, AND RESILIENT ECONOMIES. THIS INNOVATIVE APPROACH TO AGRICULTURAL RESEARCH, ENGAGEMENT, AND EDUCATION CENTERS ON THE IMPACTS AND SYNERGIES OF CONTIGUOUS RURAL AND URBAN LANDSCAPES. THIS MOSAIC OF DENSELY POPULATED AREAS NEXT TO FORESTS AND AGRICULTURAL LANDSCAPES IS UNIQUE TO PENNSYLVANIA AND THE MID-ATLANTIC REGION AND REQUIRES AN INTEGRATED STRATEGY TO ACHIEVE HEALTHY AND THRIVING AGRICULTURE, NATURAL SYSTEMS, ECONOMIES, AND COMMUNITIES. A PRIMARY COMPONENT OF AES AND EXTENSION WORK IN OUR COLLEGE WILL BE BUILT ON THE THREE INTEGRATED PILLARS OF INTENSIFICATION, RESILIENCE, AND REGENERATION OF AGRICULTURAL LANDSCAPES AS SOLUTIONS TO SOME OF THE MOST VEXING PROBLEMS CONFRONTING PENNSYLVANIA AND SIMILAR MOSAIC LANDSCAPES WORLDWIDE. WE WILL HOLISTICALLY AND COMPREHENSIVELY ADDRESS THESE CRITICAL ISSUES: INCREASING THE EFFICIENCY AND PROFITABILITY OF AGRICULTURAL PRODUCTION WHILE MINIMIZING ENVIRONMENTAL IMPACTS AND IMPROVE HUMAN HEALTH, EQUIPPING FARMERS TO ABSORB AND RECOVER FROM SHORT-TERM EMERGENCIES AND LONG-TERM STRESSES TO THEIR AGRICULTURAL PRODUCTION AND LIVELIHOODS, OPTIMIZING PLANTS, ANIMALS, AND ECOSYSTEMS FOR RESILIENCE TO AND FASTER RECOVERY FROM ENVIRONMENTALLY RELATED STRESSES, DEVELOPING STRATEGIES FOR BETTER MANAGEMENT OF NUTRIENT INPUTS AND OUTPUTS ACROSS COMPLEX AGRICULTURAL AND NATURAL RESOURCE SYSTEMS, FROM LOCAL FIELDS AND FARMS TO LARGE WATERSHEDS, HARNESSING SPATIAL DATA AND REMOTE SENSING TECHNOLOGIES TO MAP AND MODEL PREDICTIVE SIMULATIONS OF ENVIRONMENTAL CHANGE.

COMPUTER-AIDED HUMAN CENTRIC CYBER SITUATION AWARENESS

HATCH ACT FORMULA FUNDING FOR AGRICULTURAL RESEARCH ACTIVITIES

SPRAY AND COMBUSTION OF GELLED HYPERGOLIC PROPELLANTS FOR FUTURE ROCKET AND MISSILE ENGINES

THE PURPOSE OF THIS AGREEMENT IS TO FUND RESEARCH IN SUPPORT OF BTO IN THE AMOUNT OF 849,870 ON CONTRACT HR0011-17-2-0055.

THE COLLEGE OF AGRICULTURAL SCIENCES AT PENN STATE WILL PROVIDE COMPREHENSIVE SUPPORT TO THE RESIDENTS OF PENNSYLVANIA THROUGH THE A CTIVITIES OF THE PENNSYLVANIA AGRICULTURAL EXPERIMENT STATION (AES) AND PENN STATE EXTENSION (EXTENSION). WE WILL BE RESPONSIVE TO STAKEHOLDER NEEDS THROUGH TRANSLATIONAL RESEARCH AND DELIVERY OF SCIENCE-BASED PROGRAMS TO CLIENTELE, BUT WE WILL ALSO CONDUCT REGION ALLY, NATIONALLY, AND INTERNATIONALLY RELEVANT FUNDAMENTAL RESEARCH THAT GENERATES BASELINE DATA TO SOLVE FUTURE NEEDS RELATIVE TO AGRICULTURE AND NATURAL RESOURCES AND ACTIVELY SEEK NEW AND BETTER WAYS TO COMMUNICATE OUR PROGRAMS TO NEW AUDIENCES. OUR FACULTY AND STAFF, SUPPORTED BY FEDERAL BASE FUNDING (TO INCLUDE HATCH AND MULTISTATE HATCH FUNDS), WILL EFFECTIVELY LEVERAGE THIS INVESTMENT AGAINST MANY OTHER EXTERNAL FUNDING SOURCES TO CONDUCT PROGRAMS OF THE HIGHEST CALIBER. WE ARE COMMITTED TO EXCELLENCE IN RESEARCH, EDUCATING THE NEXT GENERATION OF AGRICULTURAL PROFESSIONALS AND CITIZENS, AND PROMOTING LIFE-LONG LEARNING AMONG THE CITIZENS OF PENNSYLVANIA AND WITHIN THE REGION AND NATION. OUR MISSION IS CLEAR: 'THE MISSION OF THE COLLEGE OF AGRICULTURAL SCIENCES IS TO DISCOVER, INTEGRATE, TRANSLATE, AND DISSEMINATE KNOWLEDGE TO ENHANCE THE FOOD AND AGRICULTURAL SYSTEM, NATURAL RESOURCES AND ENVIRONMENTAL STEWARDSHIP, AND ECONOMIC AND SOCIAL WELLBEING, THEREBY IMPROVING THE LIVES OF PEOPLE IN PENNSYLVANIA, THE NATION, AND THE WORLD.' AGRICULTURE FACES CHALLENGES OF RISING ENERGY COSTS, WEATHER EXTREMES, AN EXPANDING HUMAN POPULATION, ENVIRONMENTAL DEGRADATION, LOSS OF BIODIVERSITY, LABOR SHORTAGES, ARMED CONFLICT, AND A LINGERING PANDEMIC. TO HELP MEET THESE CHALLENGES, WE ARE DEVELOPING A CONCEPTUAL FRAMEWORK BASED ON THE SCIENCE OF AGRICULTURAL SUSTAINABILITY, DEFINED AS THE INTEGRATION OF NATURAL AND SOCIAL SCIENCES TO INFORM PRACTICE AND POLICY FOR PRODUCTIVE, WORKING LANDSCAPES, HEALTHY WATERSHEDS, AND RESILIENT ECONOMIES. THIS INNOVATIVE APPROACH TO AGRICULTURAL RESEARCH, ENGAGEMENT, AND EDUCATION CENTERS ON THE IMPACTS AND SYNERGIES OF CONTIGUOUS RURAL AND URBAN LANDSCAPES. THIS MOSAIC OF DENSELY POPULATED AREAS NEXT TO FORESTS AND AGRICULTURAL LANDSCAPES IS UNIQUE TO PENNSYLVANIA AND THE MID-ATLANTIC REGION AND REQUIRES AN INTEGRATED STRATEGY TO ACHIEVE HEALTHY AND THRIVING AGRICULTURE, NATURAL SYSTEMS, ECONOMIES, AND COMMUNITIES. A PRIMARY COMPONENT OF AES AND EXTENSION WORK IN OUR COLLEGE WILL BE BUILT ON THE THREE INTEGRATED PILLARS OF INTENSIFICATION, RESILIENCE, AND REGENERATION OF AGRICULTURAL LANDSCAPES AS SOLUTIONS TO SOME OF THE MOST VEXING PROBLEMS CONFRONTING PENNSYLVANIA AND SIMILAR MOSAIC LANDSCAPES WORLDWIDE. WE WILL HOLISTICALLY AND COMPREHENSIVELY ADDRESS THESE CRITICAL ISSUES: INCREASING THE EFFICIENCY AND PROFITABILITY OF AGRICULTURAL PRODUCTION WHILE MINIMIZING ENVIRONMENTAL IMPACTS AND IMPROVE HUMAN HEALTH, EQUIPPING FARMERS TO ABSORB AND RECOVER FROM SHORT-TERM EMERGENCIES AND LONG-TERM STRESSES TO THEIR AGRICULTURAL PRODUCTION AND LIVELIHOODS, OPTIMIZING PLANTS, ANIMALS, AND ECOSYSTEMS FOR RESILIENCE TO AND FASTER RECOVERY FROM ENVIRONMENTALLY RELATED STRESSES, DEVELOPING STRATEGIES FOR BETTER MANAGEMENT OF NUTRIENT INPUTS AND OUTPUTS ACROSS COMPLEX AGRICULTURAL AND NATURAL RESOURCE SYSTEMS, FROM LOCAL FIELDS AND FARMS TO LARGE WATERSHEDS, HARNESSING SPATIAL DATA AND REMOTE SENSING TECHNOLOGIES TO MAP AND MODEL PREDICTIVE SIMULATIONS OF ENVIRONMENTAL CHANGE.

SHIP COVID TESTING AND MITIGATION

INNOVATION AND ENHANCEMENTS FOR CONSORTIUM OF BIG-10 UNIVERSITY RESEARCH AND TRAINING REACTORS

MONOLITHIC SILICON MICROBOLOMETER MATERIALS FOR UNCOOLED INFRARED DETECTORS

TAS::89 0336::TAS RECOVERY ONE-TON (3.5 KW THERMAL) THERMOACOUSTIC AIR CONDITIONER THIS TEAM LED BY PENN STATE UNIVERSITY PROPOSES A THERMOAC

THE WEAPONS AND PROTECTIVE SYSTEMS TECHNOLOGIES CENTER - A CRIMINAL JUSTICE TECHNOLOGY CENTER OF EXCELLENCE

ACTIVATION OF THE AH RECEPTOR AND EPITHELIAL INTEGRITY

VISION: VALIDATED SYSTEMATIC INTEGRATION OF EPIGENOMIC DATA

HATCH ACT FORMULA FUNDING PROGRAM

BUS TESTING PROGRAM

BUS TESTING PROGRAM

(MURI) REIMAGINING ATOMS AND PHOTONS IN SYNTHETIC, DYNAMICAL, AND INTERACTING QUANTUM MATTER (RAPSYDY IN Q)

HATCH ACT FORMULA CAPACITY FUNDING PROGRAM

HATCH ACT FORMULA CAPACITY FUNDING PROGRAM

COOPERATIVE EXTENSION PROGRAMS AT 1862 LAND-GRANT INSITUTION

REGIONAL BRAIN MANGANESE ACCUMULATION AND FUNCTIONAL CONSEQUENCES IN WELDERS

HATCH ACT FORMULA FUNDING PROGRAM

PARENT-TO-CHILD ANXIETY TRANSMISSION IN EARLY CHILDHOOD: CAPTURING IN-THE-MOMENT MECHANISMS THROUGH EMOTION MODELING AND BIOLOGICAL SYNCHRONY - PREVIOUS STUDIES HAVE IDENTIFIED THREE CENTRAL PATHWAYS OF PARENT-TO-CHILD ANXIETY TRANSMISSION: (1) SHARED GENETIC LOAD, (2) FETAL PROGRAMMING THROUGH MATERNAL EXPERIENCES DURING PREGNANCY, AND (3) PARENTAL BEHAVIORS THAT MODEL AND SHAPE ANXIETY-LINKED COGNITIVE, BEHAVIORAL, AND EMOTIONAL PROFILES. TO DATE, WE HAVE FEW TRACTABLE MECHANISMS BY WHICH WE CAN INTERVENE UPON THE FIRST TWO PATHWAYS. HOWEVER, A WIDE AND ROBUST LITERATURE HAS CHARACTERIZED SPECIFIC PARENTING BEHAVIORS LINKED TO THE EMERGENCE OF CHILDHOOD ANXIETY, MAKING IT A TRANSLATABLE TARGET. MUCH OF THIS LITERATURE HAS FOCUSED ON BROAD PROFILES BASED ON QUESTIONNAIRE MEASURES OR AGGREGATE SUMMARIES OF BEHAVIORS AVERAGED OVER TIME. AS A RESULT, WE KNOW LITTLE REGARDING THE MOMENT- BY-MOMENT INTERACTIONS THAT SERVE AS A BEHAVIORAL CONDUIT FOR INTERGENERATIONAL TRANSMISSION. REPEATED DAILY INTERACTIONS WITH CAREGIVERS, CHANNELED THROUGH DYADIC SOCIAL DYNAMICS, ATTUNE THE CHILD TO PARENTAL EXPRESSIONS OF FEAR AND DISTRESS INFLUENCING THE CHILD'S OWN RESPONSES TO SURROUNDING EVENTS. THE CURRENT LONGITUDINAL STUDY WILL FOCUS ON TWO INSTANCES OF DYADIC SOCIAL DYNAMICS AS MECHANISMS FOR ANXIETY TRANSMISSION. FIRST IS DYADIC SYNCHRONY, A PROCESS CAPTURED IN THE TEMPORAL CO-ORDINATION OF DISCRETE MICROLEVEL SIGNALS BETWEEN DYADIC PARTNERS EVIDENT ACROSS LEVELS OF ANALYSIS. SECOND IS EMOTION MODELING, IN WHICH OBSERVED PATTERNS OF PARENTAL EMOTION, DISTRESS, AND COPING ARE INTERNALIZED BY THE CHILD, SUPPORTED BY PSYCHOPHYSIOLOGICAL SYNCHRONY, AND THEN REFLECTED IN THEIR OWN SUBSEQUENT BEHAVIOR. CHILDREN AGES 4 TO 6 AND THEIR PARENT, INCLUDING BOTH MOTHERS AND FATHERS, WILL BE ASSESSED AT FIVE TIME POINTS, 6 MONTHS APART IN A MULTI- MODAL BATTERY. PARENT-CHILD DYADS WILL ENGAGE IN MILDLY STRESSFUL INTERACTIONS THAT ALLOW US TO CAPTURE NEURAL (FNIRS), PSYCHOPHYSIOLOGICAL (RSA), ATTENTIONAL (MOBILE EYE-TRACKING), AND BEHAVIORAL (OVERT EMOTION AND DISTRESS) PATTERNS OF SYNCHRONY. IN ADDITION, WE WILL ASSESS REGULATORY (EEG DELTA-BETA COUPLING), COGNITIVE (ERP N2 COMPONENT), AND ATTENTIONAL (THREAT BIAS) MARKERS OF SOCIOEMOTIONAL DEVELOPMENT AND ANXIETY RISK. FINALLY, WE ASSES CHILD FEARFUL TEMPERAMENT, WHICH IS ASSOCIATED WITH GREATER SENSITIVITY TO THE SOCIAL ENVIRONMENT AND THE LATER EMERGENCE OF ANXIETY. THUS, WE CAN ASK (1) CONCURRENTLY, HOW DO PATTERNS OF DYADIC SOCIAL DYNAMICS VARY ACROSS PARENT-CHILD PAIRS? (2) ACROSS TASKS, TO WHAT EXTENT DOES VARIATION IN DYADIC PATTERNS HELP PREDICT ANXIETY RISK? (3) OVER TIME, CAN WE PREDICT SOCIOEMOTIONAL PROFILES AND ANXIETY RISK FROM EARLIER PATTERNS OF DYNAMIC DYADIC INTERACTIONS? REFLECTING THE RESEARCH DOMAIN CRITERIA, WE INTEGRATE MULTILEVEL MECHANISMS BY EXAMINING HOW SOCIAL AND AROUSAL/REGULATORY SYSTEMS ARE COUPLED THROUGH DYADIC SOCIAL DYNAMICS TO INFLUENCE THE EMERGENCE OF ANXIETY VIA THE COGNITIVE (ATTENTION TO THREAT, COGNITIVE CONTROL), AROUSAL/REGULATORY (DELTA-BETA COUPLING), AND NEGATIVE VALENCE (FEARFUL TEMPERAMENT) SYSTEMS. IN DOING SO WE HEED THE CALL TO EXAMINE DEVELOPMENT AND THE ENVIRONMENT AS “BIDIRECTIONAL INFLUENCES” ON TRANSDIAGNOSTIC PROCESSES OF PSYCHOPATHOLOGY IN ORDER TO TRANSLATE OUR FINDINGS TO DYADIC TREATMENT APPROACHES.

THE CLEARINGHOUSE FOR MILITARY FAMILY READINESS HAS BEEN LOCATED AT THE PENNSYLVANIA STATE UNIVERSITY (CLEARINGHOUSE) FOR THE LAST 10 YEARS. THIS CONTINUATION FUNDING REPRESENTS THE NEXT PHASE OF WORK FOR THE CLEARINGHOUSE OPERATIONS, RESOURCE CENTER FOR IMPROVING FAMILY HEALTH BEHAVIORS, THE THRIVE PARENTING INITIATIVE, DEPARTMENT OF DEFENSE (DOD) FAMILY ADVOCACY PROGRAM (FAP) SUPPORT, A VETTING SYSTEM FOR ONLINE RESOURCES, ARMY FAP PREVENTION AND RESEARCH PROJECT, AND ARMY NPSP.THE CLEARINGHOUSE IS AN APPLIED RESEARCH CENTER COMMITTED TO ADVANCING THE HEALTH AND WELL-BEING OF SERVICE MEMBERS, VETERANS, AND THEIR FAMILIES. THIS FOCUS IS ESSENTIAL AND PROMOTES FAMILY RESILIENCE, WHICH IS A SIGNIFICANT PREDICTOR OF MILITARY READINESS, THAT IS, THE ABILITY OF SERVICE MEMBERS TO EFFECTIVELY EXECUTE THEIR MISSIONS. FAMILY SATISFACTION WITH THE MILITARY IS THE STRONGEST PREDICTOR OF SERVICE MEMBER RETENTION. THUS, RESILIENT MILITARY FAMILIES ARE ESSENTIAL TO NATIONAL SECURITY, THE STABILITY OF THE ARMED FORCES, AND THE HEALTH AND WELL-BEING OF MILLIONS OF MILITARY CHILDREN. THE HEALTH AND WELL-BEING OF SERVICE MEMBERS AND THEIR FAMILIES.THE CLEARINGHOUSE TAKES A SOLUTION-ORIENTED APPROACH THAT INCLUDES WRITING RESEARCH REPORTS, CONDUCTING APPLIED RESEARCH STUDIES, BUILDING WORKFORCE EXPERTISE THROUGH TRAINING AND RESOURCE PROVISION, IMPLEMENTING AND EVALUATING EVIDENCE-INFORMED PROGRAMS AND PRACTICES, AND DELIVERING OBJECTIVE DATA AND POLICY-RELEVANT FINDINGS SO THAT DECISIONS ARE BASED ON THE MOST RIGOROUS SCIENCE AND EVIDENCE AVAILABLE.

PENNSYLVANIA STATE UNIVERSITY "DEVELOPMENT OF HIGH-ENERGY-DENSITY LITHIUM-SULFUR CELLS" NEW AWARD, 000.

WE PROPOSE TO BUILD AN X-RAY CODED APERTURE TELESCOPE (BLACKCAT) DESIGNED FOR OBSERVATIONS OF.BRIGHT X-RAY SOURCES IN THE 0.5-20 KEV BAND..

IMPROVE EXISTING AIRPORT

LYCORMA DELICATULA (HEMIPTERA: FULGORIDAE), THE SPOTTED LANTERNFLY (SLF), IS A SAP-FEEDING PLANTHOPPER THAT WAS FIRST DETECTED IN EASTERN PENNSYLVANIA IN 2014. SINCE THAT TIME, IT HAS EXPANDED ITS RANGE AND AS OF 2025, HAS ESTABLISHED POPULATIONS IN 19 STATES IN THE US. WHILE IT FEEDS ON OVER 100 SPECIES OF PLANTS AND TREES, ONE OF ITS MOST HIGHLY PREFERRED HOSTS IS GRAPEVINE. SLF FEEDING CAN HAVE NUMEROUS NEGATIVE IMPACTS ON GRAPEVINES, AND IN THE MID-ATLANTIC WHERE IT HAS BEEN INFESTING VINEYARDS THE LONGEST, IT IS CAUSING DAMAGE TO GRAPEVINES, AND SIGNIFICANT ECONOMIC LOSS TO GROWERS. WE WILL CONDUCT FIELD EXPERIMENTS WITH CAGED GRAPEVINES AND IN VINEYARDS TO ASSESS IMPACTS OF SLF FEEDING ON THE HEALTH, FRUIT, WINE AND JUICE QUALITY OF ECONOMICALLY IMPORTANT GRAPE SPECIES, AND CONDUCT VINEYARD SURVEYS TO DETERMINE IF SLF PRESENCE CHANGES THE PREVALENCE OF, OR EXACERBATES DAMAGE FROM COMMON GRAPEVINE DISEASES. WE WILL CONDUCT EXPERIMENTS IN VINEYARDS AND IN AREAS SURROUNDING VINEYARDS TO IDENTIFY THE MOST EFFECTIVE AND RELIABLE MONITORING TOOLS AND TREATMENT METHODS FOR PROTECTING GRAPEVINE HEALTH AND PREVENTING SLF CONTAMINATION OF HARVESTED GRAPES AND DOWNSTREAM GRAPE PRODUCTS. BASED ON OUR FINDINGS, THE NEW AND REVISED MONITORING AND MANAGEMENT TOOLS AND RECOMMENDATIONS THAT WE DEVELOP WILL BE DISSEMINATED TO GRAPE STAKEHOLDERS AND THE PUBLIC THROUGH A WIDE ARRAY OF TRADITIONAL AND CONTEMPORARY OUTREACH CHANNELS THROUGH OUR PARTNERING LAND GRANT EXTENSION UNIVERSITIES, USDA AGENCIES, REGIONAL IPM CENTERS, AND THE NGRA AND ITS STAKEHOLDER GROUPS. OUR WORK WILL PROVIDE GROWERS WITH A WIDE RANGE OF SLF INTEGRATED PEST MANAGEMENT (IPM) TOOLS THAT CAN BE EMPLOYED AT MULTIPLE SCALES IN AND AROUND VINEYARDS, BASED ON REGIONAL AND MARKET SPECIFIC NEEDS. THIS WILL RESULT IN MORE EFFECTIVE SLF MONITORING AND MANAGEMENT THAT WILL REDUCE NUMBER OF BROAD-SPECTRUM SPRAYS APPLIED AND THEIR ASSOCIATED COSTS, AS WELL AS REDUCE GRAPEVINE DAMAGE AND SLF IMPACTS TO DOWNSTREAM GRAPE PRODUCTS.

PENNSYLVANIA SPACE GRANT CONSORTIUM.

CADHERIN REGULATION IN DERMAL ENDOTHELIAL CELLS

PURPOSE: REHABILITATE TAXIWAY. ACTIVITIES TO BE PERFORMED/EXPECTED OUTCOMES: THIS PROJECT REHABILITATES 6,600 FEET OF THE EXISTING TAXIWAY A PAVEMENT THAT REQUIRES REHABILITATION TO ENSURE SAFE AIRFIELD OPERATIONS. THIS GRANT FUNDS THE SIXTH PHASE, WHICH CONSISTS OF REHABILITATION OF 450 FEET. INTENDED BENEFICIARY: THIS GRANT WILL PROVIDE FEDERAL FUNDING FOR AIRPORTS ASSOCIATED WITH STATE COLLEGE, PENNSYLVANIA.

HATCH ACT FORMULA FUNDING PROGRAM

POPULATION RESEARCH INSTITUTE

DISCOVERY OF MULTIMODAL BIOMARKERS FOR PARKINSONIAN SYNDROMES, THEIR PROGRESSION, AND PATHOLOGICAL RELEVANCE

USE OF A GLP-1 AGONIST TO TREAT OPIOID USE DISORDER IN RATS AND MAN

THE ATMOSPHERIC CARBON AND TRANSPORT-AMERICA (ACT-AMERICA) MISSION WILL ADVANCE SOCIETY S ABILITY TO PREDICT AND MANAGE FUTURE CLIMATE CHANGE BY ENAB

SMITH LEVER 3B&C FUNDS

COMPUTATIONAL MESOSCALE SCIENCE AND OPEN SOFTWARE FOR QUANTUM MATERIALS

APPLICATION PURPOSE: THE PURPOSE OF THIS AWARD IS TO CONTINUE FUNDING SUPPORT FOR THE OPERATION OF THE FTA BUS TESTING CENTER AT PENN STATE UNIVERSITYS LARSON TRANSPORTATION INSTITUTE (LTI). THIS WORK INVOLVES PERFORMING FEDERALLY MANDATED TESTING OF TRANSIT BUSES TO SATISFY THE REQUIREMENTS IN 49 U.S.C. 5318 AND 49 CFR PART 665.; ACTIVITIES PERFORMED: THE ACTIVITIES CONDUCTED UNDER THIS AWARD INVOLVE THE CONTINUATION OF TESTING ON NEW BUS MODELS AND PREVIOUSLY TESTED BUS MODELS PRODUCED WITH MAJOR CHANGES THAT ARE INTENDED TO BE PURCHASED USING FTA FUNDING. BUSES WILL BE TESTED FOR MAINTAINABILITY RELIABILITY SAFETY PERFORMANCE (INCLUDING BRAKING PERFORMANCE) STRUCTURAL INTEGRITY FUEL ECONOMY EMISSIONS AND NOISE. LTI WILL PREPARE A COMPREHENSIVE TEST REPORT FOR EACH BUS MODEL TESTED THAT WILL PROVIDE A PASS/FAIL SCORE IN ACCORDANCE WITH THE FEDERAL REGULATION.; EXPECTED OUTCOMES: THE EXPECTED OUTCOME TO THIS WORK IS TO PROVIDE COMPREHENSIVE TEST RESULTS THAT WILL SATISFY STATUTORY AND REGULATORY REQUIREMENTS AND INFORM THE DECISION MAKING OF FTA GRANTEES DURING THE PROCUREMENT PROCESS. REPORTS WILL PROVIDE A PASS/FAIL SCORE THAT DETERMINES WHETHER A NEW BUS MODEL MEETS THE MINIMUM EXPECTED PERFORMANCE CRITERIA NECESSARY TO BE ELIGIBLE FOR FTA FUNDING.; INTENDED BENEFICIARIES: THE INTENDED BENEFICIARIES OF THIS WORK INCLUDE TAXPAYERS; FTA GRANTEES PROCURING NEW BUS MODELS; BUS MANUFACTURERS THAT WILL ENHANCE THE PERFORMANCE RELIABILITY AND SAFETY OF THEIR VEHICLES; AND TRANSIT USERS WHO WILL BENEFIT FROM MORE RELIABLE EFFICIENT AND SAFER BUSES.; SUBRECIPIENT ACTIVITIES: NONE

PREDICTING IPSILESIONAL MOTOR DEFICITS IN STROKE WITH DYNAMIC DOMINANCE MODEL

DIRECTED ASSEMBLY OF MOLECULAR LOGIC ARCHITECTRURES USING FUNCTIONALIZED METALLIC NANOWIRES

APPLICATION PURPOSE: THE PURPOSE OF THIS AWARD IS TO CONTINUE FUNDING SUPPORT FOR THE OPERATION OF THE FTA BUS TESTING CENTER AT PENN STATE UNIVERSITYS LARSON TRANSPORTATION INSTITUTE (LTI). THIS WORK INVOLVES PERFORMING FEDERALLY MANDATED TESTING OF TRANSIT BUSES TO SATISFY THE REQUIREMENTS IN 49 U.S.C. 5318 AND 49 CFR PART 665.; ACTIVITIES PERFORMED: THE ACTIVITIES CONDUCTED UNDER THIS AWARD INVOLVE THE CONTINUATION OF TESTING ON NEW BUS MODELS AND PREVIOUSLY TESTED BUS MODELS PRODUCED WITH MAJOR CHANGES THAT ARE INTENDED TO BE PURCHASED USING FTA FUNDING. BUSES WILL BE TESTED FOR MAINTAINABILITY RELIABILITY SAFETY PERFORMANCE (INCLUDING BRAKING PERFORMANCE) STRUCTURAL INTEGRITY FUEL ECONOMY EMISSIONS AND NOISE. LTI WILL PREPARE A COMPREHENSIVE TEST REPORT FOR EACH BUS MODEL TESTED THAT WILL PROVIDE A PASS/FAIL SCORE IN ACCORDANCE WITH THE FEDERAL REGULATION.; EXPECTED OUTCOMES: THE EXPECTED OUTCOME TO THIS WORK IS TO PROVIDE COMPREHENSIVE TEST RESULTS THAT WILL INFORM THE DECISION MAKING OF FTA GRANTEES DURING THE PROCUREMENT PROCESS. REPORTS WILL ALSO PROVIDE A PASS/FAIL SCORE THAT DETERMINES WHETHER A NEW BUS MODEL MEETS THE MINIMUM EXPECTED PERFORMANCE CRITERIA NECESSARY TO BE ELIGIBLE FOR FTA FUNDING.; INTENDED BENEFICIARIES: THE INTENDED BENEFICIARIES OF THIS WORK INCLUDE TAXPAYERS FTA GRANTEES PROCURING NEW BUS MODELS BUS MANUFACTURERS THAT WILL ENHANCE THE PERFORMANCE RELIABILITY AND SAFETY OF THEIR VEHICLES AND TRANSIT USERS WHO WILL BENEFIT FROM MORE RELIABLE EFFICIENT AND SAFER BUSES.; SUBRECIPIENT ACTIVITIES: THERE ARE NO SUBRECIPIENTS UNDER THIS AWARD.

GENOMIC BASIS OF PHENOTYPIC VARIABILITY OF COMPLEX DISORDERS

THE PURPOSE OF THIS AGREEMENT IS TO FUND RESEARCH SUPPORTING DSO IN THE AMOUNT OF 535,000 ON CONTRACT HR0011-17-2-0032.

THE NEXT FACILITY-CLASS X-RAY ASTRONOMY OBSERVATORY WILL BE ESA'S ATHENA MISSION, TO BE LAUNCHED IN 2028. ONE OF THE CORE ATHENA INSTRUMENTS, THE WI

ACCISIS-CHICAGO

APPLICATION PURPOSE: THE PURPOSE OF THIS AWARD IS TO CONTINUE FUNDING SUPPORT FOR THE OPERATION OF THE FTA BUS TESTING CENTER AT PENN STATE UNIVERSITYS LARSON TRANSPORTATION INSTITUTE (LTI). THIS WORK INVOLVES PERFORMING FEDERALLY MANDATED TESTING OF TRANSIT BUSES TO SATISFY THE REQUIREMENTS IN 49 U.S.C. 5318 AND 49 CFR PART 665.; ACTIVITIES PERFORMED: THE ACTIVITIES CONDUCTED UNDER THIS AWARD INVOLVE THE CONTINUATION OF TESTING ON NEW BUS MODELS AND PREVIOUSLY TESTED BUS MODELS PRODUCED WITH MAJOR CHANGES THAT ARE INTENDED TO BE PURCHASED USING FTA FUNDING. BUSES WILL BE TESTED FOR MAINTAINABILITY RELIABILITY SAFETY PERFORMANCE (INCLUDING BRAKING PERFORMANCE) STRUCTURAL INTEGRITY FUEL ECONOMY EMISSIONS AND NOISE. LTI WILL PREPARE A COMPREHENSIVE TEST REPORT FOR EACH BUS MODEL TESTED THAT WILL PROVIDE A PASS/FAIL SCORE IN ACCORDANCE WITH THE FEDERAL REGULATION.; EXPECTED OUTCOMES: THE EXPECTED OUTCOME TO THIS WORK IS TO PROVIDE COMPREHENSIVE TEST RESULTS THAT WILL INFORM THE DECISION MAKING OF FTA GRANTEES DURING THE PROCUREMENT PROCESS. REPORTS WILL ALSO PROVIDE A PASS/FAIL SCORE THAT DETERMINES WHETHER A NEW BUS MODEL MEETS THE MINIMUM EXPECTED PERFORMANCE CRITERIA NECESSARY TO BE ELIGIBLE FOR FTA FUNDING.; INTENDED BENEFICIARIES: THE INTENDED BENEFICIARIES OF THIS WORK INCLUDE TAXPAYERS FTA GRANTEES PROCURING NEW BUS MODELS BUS MANUFACTURERS THAT WILL ENHANCE THE PERFORMANCE RELIABILITY AND SAFETY OF THEIR VEHICLES AND TRANSIT USERS WHO WILL BENEFIT FROM MORE RELIABLE EFFICIENT AND SAFER BUSES.; SUBRECIPIENT ACTIVITIES: THERE ARE NO SUBRECIPIENTS UNDER THIS AWARD.

SMITH LEVER 3B&C FUNDS

SMITH LEVER 3B&C FUNDS

UNCONVENTIONAL DIELECTRIC MATERIALS AND STRUCTURES FOR ULTRA-HIGH PERFORMANCE PULSED POWER CAPACITORS

VERTICAL LIFT RESEARCH CENTER OF EXCELLENCE

CZO: SUSQUEHANNA/SHALE HILLS CRITICAL ZONE OBSERVATORY

PURPOSE OF THE AWARD: THE PURPOSE OF THIS AWARD IS TO CONTINUE FUNDING SUPPORT FOR THE OPERATION OF THE FTA BUS TESTING CENTER AT PENN STATE UNIVERSITYS LARSON TRANSPORTATION INSTITUTE (LTI). THIS WORK INVOLVES PERFORMING FEDERALLY MANDATED TESTING OF TRANSIT BUSES TO SATISFY THE REQUIREMENTS IN 49 U.S.C. 5318 AND 49 CFR PART 665. ACTIVITIES TO BE PERFORMED: THE ACTIVITIES CONDUCTED UNDER THIS AWARD INVOLVE THE CONTINUATION OF TESTING ON NEW BUS MODELS AND PREVIOUSLY TESTED BUS MODELS PRODUCED WITH MAJOR CHANGES THAT ARE INTENDED TO BE PURCHASED USING FTA FUNDING. BUSES WILL BE TESTED FOR MAINTAINABILITY RELIABILITY SAFETY PERFORMANCE (INCLUDING BRAKING PERFORMANCE) STRUCTURAL INTEGRITY FUEL ECONOMY EMISSIONS NOISE. LTI WILL PREPARE A COMPREHENSIVE TEST REPORT FOR EACH BUS MODEL TESTED THAT WILL PROVIDE A PASS/FAIL SCORE IN ACCORDANCE WITH THE FEDERAL REGULATION. EXPECTED OUTCOMES: THE EXPECTED OUTCOME TO THIS WORK IS TO PROVIDE COMPREHENSIVE TEST RESULTS THAT WILL INFORM THE DECISION MAKING OF FTA GRANTEES DURING THE PROCUREMENT PROCESS. REPORTS WILL ALSO PROVIDE A PASS/FAIL SCORE THAT DETERMINES WHETHER A NEW BUS MODEL MEETS THE MINIMUM EXPECTED PERFORMANCE CRITERIA NECESSARY TO BE ELIGIBLE FOR FTA FUNDING. INTENDED BENEFICIARIES: THE INTENDED BENEFICIARIES OF THIS WORK INCLUDE TAXPAYERS FTA GRANTEES PROCURING NEW BUS MODELS BUS MANUFACTURERS THAT WILL ENHANCE THE PERFORMANCE RELIABILITY AND SAFETY OF THEIR VEHICLES AND TRANSIT USERS WHO WILL BENEFIT FROM MORE RELIABLE EFFICIENT AND SAFER BUSES. SUBRECIPIENT ACTIVITIES: THERE ARE NO SUBRECIPIENTS UNDER THIS AWARD.

FEED THE FUTURE INNOVATION LAB FOR CLIMATE RESILIENCE IN BEANS

NATIONAL STEM TEACHER CORPS PILOT PROGRAM: ELEVATING ELEMENTARY TEACHERS AS THE FRONTIER OF STEM EDUCATION -THE NATIONAL STEM TEACHER CORPS PILOT PROGRAM REGIONAL ALLIANCE PROJECT ELEVATING ELEMENTARY TEACHERS AS THE FRONTIER OF STEM EDUCATION AIMS TO RECOGNIZE OUTSTANDING STEM EDUCATORS IN HIGH-NEED SCHOOLS THAT ADVANCE EDUCATIONAL EXCELLENCE IN THE MID-ATLANTIC REGION. THIS PROJECT INTENDS TO SUPPORT 27 STEM TEACHER CORPS MEMBERS BY RECOGNIZING AND REWARDING THEIR ACCOMPLISHMENTS AND EFFORTS TO ENHANCE STEM TEACHING AND LEARNING IN K-5 CLASSROOMS. TO ELEVATE THESE TEACHERS AND THEIR WORK, TEACHER CORPS MEMBERS WILL RECEIVE ANNUAL STIPENDS, SPECIALIZED PROFESSIONAL DEVELOPMENT IN STEM CURRICULUM AND EDUCATIONAL LEADERSHIP, AND CLASSROOM MATERIALS AND TRAVEL SUPPORT TO REGIONAL WORKSHOPS AND SCIENCE TEACHER CONFERENCES. THE PROJECT WILL ALSO PROVIDE SIGNIFICANT PROFESSIONAL DEVELOPMENT, MENTORSHIP, AND SUPPORT TO HUNDREDS OF OTHER STEM TEACHERS WITHIN THE REGION THROUGH ACTIVITIES LED BY THE TEACHER CORPS MEMBERS. THE PROPOSED PROJECT COMPONENTS WILL ENABLE EXEMPLARY AND INNOVATIVE STEM TEACHERS TO PARTICIPATE IN STATE AND NATIONAL SCIENCE EDUCATION CONFERENCES, LEAD WORKSHOPS FOR K-5 TEACHERS WHO ARE NOT CORPS MEMBERS, AND BUILD AN IMPORTANT NETWORK OF SUPPORT FOR K-5 STEM EDUCATION IN THE REGION. THIS PROJECT AT PENN STATE UNIVERSITY INCLUDES PARTNERSHIPS WITH WEST VIRGINIA UNIVERSITY, THE COLLEGE OF NEW JERSEY, K-12 SCHOOLS AND SCHOOL DISTRICTS, AWARD WINNING TEACHERS IN THE REGION, STATE-LEVEL STEM EDUCATION NETWORKS, SCIENCE TEACHERS' ASSOCIATIONS, AND KEY LOCAL EDUCATION AGENCIES FROM EACH STATE. PROJECT GOALS INCLUDE EMPOWERING K-5 TEACHERS TO BECOME AGENTS OF CHANGE IN STEM EDUCATION THROUGH ENGAGING STUDENTS IN SCIENTIFIC AND ENGINEERING PRACTICES. BY PROVIDING TARGETED PROFESSIONAL DEVELOPMENT AND FOSTERING PEER LEADERSHIP, THE PROJECT INTENDS TO IMPROVE STUDENT OUTCOMES AND CREATE A NETWORK OF EDUCATORS EQUIPPED TO LEAD A REGIONAL TRANSFORMATION. THIS PROJECT WILL RECRUIT AND TRAIN A GROUP OF DEDICATED K-5 TEACHERS WHO WILL PARTICIPATE IN SUMMER WORKSHOPS TO ENHANCE THEIR KNOWLEDGE AND LEADERSHIP ABILITIES. THESE TEACHERS WILL THEN SUPPORT THEIR PEERS TO CREATE ENGAGING STEM LEARNING ENVIRONMENTS FOR YOUNG STUDENTS. EVALUATION OF THE PROJECT IS ITERATIVE AND GUIDED BY THE QUESTIONS: DID THE PROJECT'S EFFORTS ELEVATE THE STEM TEACHER PROFESSION AND TEACHER CORPS MEMBERS IN THE REGION BY PROMOTING STEM TEACHING AND LEARNING OPPORTUNITIES IN ELEMENTARY SCHOOLS? DID SUSTAINED STEM-FOCUSED PROFESSIONAL DEVELOPMENT AND THE EFFORTS OF THE COMMUNITIES OF PRACTICE ENHANCE ELEMENTARY TEACHERS' STEM KNOWLEDGE, CONFIDENCE, AND LEADERSHIP SKILLS? EVALUATION WILL INCLUDE FORMATIVE ASSESSMENTS TO GUIDE PROGRAM IMPROVEMENTS AND MEASURE THE PROJECT'S EFFECTIVENESS. THE PROJECT TEAM WILL ALSO ENGAGE REGIONAL AND NATIONAL ORGANIZATIONS TO DISSEMINATE PROJECT OUTCOMES AND SHARE BEST PRACTICES. THIS REGIONAL ALLIANCE PROJECT IS SUPPORTED THROUGH THE NATIONAL STEM TEACHER CORPS PILOT PROGRAM. THE NSF NATIONAL STEM TEACHER CORPS PILOT PROGRAM SUPPORTS OUTSTANDING STEM EDUCATORS IN HIGH-NEEDS SCHOOLS THAT ADVANCE EDUCATIONAL EXCELLENCE IN OUR NATION?S PREK-12 CLASSROOMS. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE PLANNED FOR THIS AWARD.

PIRE: TRANSLATING COGNITIVE AND BRAIN SCIENCE IN THE LABORATORY AND FIELD TO LANGUAGE LEARNING ENVIRONMENTS

NATIONAL CENTER FOR NANOTECHNOLOGY APPLICATIONS AND CAREER KNOWLEDGE

THE ALLIANCE FOR CRITICAL MINERAL EXTRACTION AND PRODUCTION FROM COAL-BASED RESOURCES FOR VITALITY ENHANCEMENT IN DOMESTIC SUPPLY CHAINS(ACME-REVIVE) THE PRIMARY OBJECTIVE OF THE ALLIANCE FOR CRITICAL MINERAL EXTRACTION AND PRODUCTION FROM COAL-BASED RESOURCES FOR VITALITY ENHANCEMENT IN DOMESTIC SUPPLY CHAINS (ACME-REVIVE) IS TO REVIVE A ROBUST, INTEGRATED 100% DOMESTIC SUPPLY CHAIN UTILIZING THE ENVIRONMENTALLY POLLUTING DOMESTIC WASTE COAL-BASED SECONDARY RESOURCES DOMESTIC DEVELOPED INNOVATIVE TECHNOLOGIES TO REBUILD THE RARE EARTH ELEMENTS (REE) PRODUCTION AND END-USE CRITICAL MINERAL (CM) MANUFACTURING SECTOR IN THE US FOR ENHANCED NATIONAL SECURITY.

SUPERATOMS AS BUILDING BLOCK OF NEW MATERIALS

PENNSYLVANIA SEA GRANT OMNIBUS 2018-2022

FAMILY MIGRATION AND EARLY LIFE OUTCOMES

COLLABORATIVE RESEARCH: VISUAL CORTEX ON SILICON

MOLECULAR MECHANISM OF BIDIRECTIONAL TRANSPORT - PROJECT SUMMARY BIDIRECTIONAL TRANSPORT OF VESICLES AND ORGANELLES IN CELLS INVOLVES A TUG-OF-WAR BETWEEN THE MICROTUBULE MOTORS KINESIN AND DYNEIN. THIS TRANSPORT IS PARTICULARLY IMPORTANT IN THE AXONS AND DENDRITES OF NEURONS AND IN CILIA AND FLAGELLA, AND TRANSPORT DEFECTS ARE LINKED TO NEURODEGENERATIVE DISEASES SUCH AS ALZHEIMER’S AND ALS, AS WELL AS CILIOPATHIES. ALTHOUGH MANY OF THE MOLECULAR PLAYERS ARE KNOWN, THE WORKING MECHANISMS OF THESE COMPONENT PARTS AND HOW THEIR ACTIVITIES COMBINE TO ACHIEVE THE EMERGENT PROPERTY OF BIDIRECTIONAL TRANSPORT ARE NOT SUFFICIENTLY UNDERSTOOD. THE GOAL OF THIS PROPOSAL IS TO BRIDGE THE GULF IN UNDERSTANDING BETWEEN THE MECHANOCHEMISTRY OF SINGLE KINESIN AND DYNEIN MOTORS AND THE BIDIRECTIONAL TRANSPORT DYNAMICS OF VESICLES AND ORGANELLES OBSERVED IN CELLS. UNRESOLVED QUESTIONS INCLUDE: HOW DOES LOAD AFFECT THE MECHANOCHEMISTRY AND DETACHMENT KINETICS OF DIFFERENT KINESINS AND DYNEIN? HOW DO OPPOSING MOTORS COORDINATE AND COMPETE TO ACHIEVE BIDIRECTIONAL TRANSPORT? HOW DO REGULATORY PROTEINS, MICROTUBULE ASSOCIATED PROTEINS AND TUBULIN POST- TRANSLATIONAL MODIFICATIONS ALTER THE BALANCE OF PLUS- AND MINUS-END DIRECTED MOTILITY TO ACHIEVE PROPER VECTORIAL TRANSPORT? TO ADDRESS THESE QUESTIONS, INTERFEROMETRIC SCATTERING (ISCAT) MICROSCOPY WITH NANOMETER SPATIAL PRECISION AND MILLISECOND TEMPORAL RESOLUTION WILL BE USED TO TRACK INDIVIDUAL MOTOR DOMAINS, SINGLE MOTOR PROTEINS, AND MULTI-MOTOR ASSEMBLIES AS THEY STEP ALONG THEIR MICROTUBULE TRACKS. THESE MICROSCOPY STUDIES WILL BE COMPLEMENTED BY STOPPED-FLOW KINETICS INVESTIGATIONS, IN VITRO RECONSTITUTION EXPERIMENTS, AND COMPUTATIONAL MODELING TO UNDERSTAND ASSEMBLIES OF INCREASING COMPLEXITY. SPECIFIC MOTOR MECHANISMS TO BE INVESTIGATED INCLUDE THE ORIGIN OF THE FAST SPEED AND SUPERPROCESSIVITY OF KINESIN-3, THE POLYMERASE MECHANISM OF KINESIN-5, AND THE MOLECULAR BASIS OF DYNEIN ACTIVATION BY ITS ADAPTER PROTEINS. A DNA TENSIOMETER WILL BE DEVELOPED TO UNDERSTAND THE INFLUENCE OF MECHANICAL LOAD ON KINESIN AND DYNEIN MECHANOCHEMISTRY, AND STATISTICAL TOOLS WILL BE DEVELOPED TO EXTRACT LOAD-DEPENDENT DETACHMENT KINETICS FROM THESE EXPERIMENTS. FINALLY, MULTI-MOTOR ASSEMBLIES WILL BE BUILT USING DNA ORIGAMI, WHICH ALLOWS FOR PRECISE CONTROL OF MOTOR NUMBER AND POSITIONING, AND RECONSTITUTED LIPID VESICLES, WHICH MIMIC THE MECHANICAL AND DIFFUSIONAL PROPERTIES OF INTRACELLULAR CARGO. THIS WORK WILL ADVANCE OUR UNDERSTANDING OF HOW ORGANELLES ARE CORRECTLY POSITIONED IN CELLS AND HOW SPECIFIC INTRACELLULAR CARGO ARE RELIABLY TARGETED TO THEIR PROPER CELLULAR LOCATIONS.

WORK , STRESS, HEALTH AND PARENTING AMONG HOTEL EMPOLYE*

HATCH ACT FORMULA FUNDING PROGRAM

POTENTIATED STATE OF THE HSP70 HEAT SHOCK GENE

HATCH ACT FORMULA CAPACITY FUNDING PROGRAM.

THIS PROJECT-- SECURING WATER FOR AND FROM AGRICULTURE THROUGH EFFECTIVE COMMUNITY AND STAKEHOLDER ENGAGEMENT-- WILL PROMOTE SUSTAINABLE WATER FOR AGRICULTURE BY DEVELOPING A PROVEN, FLEXIBLE, AND TRANSFERABLE MODEL OF STAKEHOLDER ENGAGEMENT THAT TRANSFORMS THE WAY SCIENTISTS, COOPERATIVE EXTENSION, AGENCY OFFICIALS, AND ENGAGEMENT SPECIALISTS APPROACH CRITICAL WATER AVAILABILITY ISSUES. THIS PROJECT WILL DEVELOP, CONDUCT, EVALUATE, AND DISSEMINATE AN ENGAGEMENT MODEL THAT WORKS ACROSS DIFFERING HYDROLOGICAL AND AGRICULTURAL CONTEXTS IN THE U.S. THE MODEL WILL BE TESTED IN THREE CASE STUDY LOCATIONS (ARIZONA, NEBRASKA, AND PENNSYLVANIA) THAT REPRESENT A RANGE OF BIOPHYSICAL AND SOCIAL CONTEXTS, YET SHARE LONG-STANDING AND EMERGING WATER AVAILABILITY CONCERNS RELATED TO WATER FOR AGRICULTURE. THE PROJECT WILL EXAMINE BASIC RESEARCH QUESTIONS ABOUT THE KNOWLEDGE-TO-ACTION PATHWAYS BY WHICH ENGAGEMENT IMPACTS INDIVIDUAL AND COLLECTIVE CAPACITY TO ADDRESS WATER AVAILABILITY CHALLENGES, LANDSCAPE MANAGEMENT BEHAVIORS, AND ULTIMATELY, WATER QUALITY AND QUANTITY OUTCOMES. CHANGES ATTRIBUTED TO THE ENGAGEMENT EFFORTS WILL BE ASSESSED AT THE INDIVIDUAL (KNOWLEDGE, ATTITUDES, BEHAVIORS, IDENTITIES), COLLECTIVE (NORMS, SOCIAL NETWORKS), AND INSTITUTIONAL (PROGRAMS, RESOURCE ALLOCATIONS, PARTNERSHIPS) LEVELS. BIOPHYSICAL IMPACTS WILL BE ASSESSED BY EXAMINING PRACTICE IMPLEMENTATION AND CHANGES IN WATER QUANTITY AND QUALITY PARAMETERS USING MODEL SIMULATIONS AND FIELD EXPERIMENTS. THE PROJECT TEAM WILL CONSULT WITH INTERNATIONAL PARTNERS (ISRAEL, AUSTRALIA) TO LEARN FROM THOSE COUNTRIES' ONGOING ENGAGEMENT AND ASSESSMENT WORK. BASED ON THESE CHANGES, PROJECT IMPACTS RANGE FROM THE INDIVIDUAL TO THE NATIONAL, WITH THE ULTIMATE GOAL TO CREATE A TRANSFERABLE MODEL OF STAKEHOLDER ENGAGEMENT THAT CAN BE USED IN ANY AREA FACING CRITICAL QUESTIONS RELATED TO WATER FOR AGRICULTURE.

BETTER TOGETHER: ENHANCING HISPANIC HEALTH IN RURAL PENNSYLVANIA THROUGH HEALTHY LIFESTYLE STRATEGIES

STRUCTURAL STUDIES OF CHROMATIN COMPLEXES

REGULATION OF SKELETAL MUSCLE METABOLISM

POST-DOCTORAL RESEARCH FELLOWSHIPS

OPERATION OF THE FTA BUS TESTING PROGRAM

ORBEX: PRIMARY PREVENTION OF ASTHMA AND WHEEZING IN CHILDREN-DCC

USING DROSOPHILA NEURONS TO IDENTIFY MECHANISMS THAT CONTROL MICROTUBULE POLARITY

REHABILITATION ENGINEERING RESEARCH CENTER ON AUGMENTATIVE AND ALTERNATIVE COMMUNICATION (THE RERC ON AAC)

REHABILITATION ENGINEERING RESEARCH CENTER ON AUGMENTATIVE AND ALTERNATIVE COMMUNICATION (THE RERC ON AAC)

THE ORIGINS OF MOLECULES IN DIVERSE SPACE AND PLANETARY ENVIRONMENTS AND THEIR INTRAMOLECULAR ISOTOPE SIGNATURES

THE NACK NATIONAL NETWORK FOR NANOTECHNOLOGY WORKFORCE DEVELOPMENT

PROMOTER REGULATION IN RESPONSE TO ENVIRONMENTAL STRESS

ADVANCING TURBINE TECHNOLOGIES FOR RELEVANT INLET TEMPERATURE PROFILES IN THE STEADY THERMAL AERO RESEARCH TURBINE (START) LAB THE OVERALL GOAL OF THIS PROJECT IS TO INVESTIGATE TECHNOLOGY ADVANCES TO MEET THE GOAL OF SIMPLE CYCLE GAS TURBINE EFFICIENCY INCREASING TO 67% WHILE EXPANDING POTENTIAL RANGES OF FUELS AND COMBUSTOR DESIGNS. SPECIFICALLY, THIS PROJECT WILL EVALUATE THE USE OF HIGH TEMPERATURE MATERIALS, NAMELY CERAMIC MATRIX COMPOSITES (CMCS) WITH THE INTENTION OF REDUCING THE NEED FOR TURBINE COOLING AIR, WHICH IS A PARASITIC LOSS IN TERMS OF EFFICIENCY.

EMERGING RELATIONS BETWEEN ATTENTION AND NEGATIVE AFFECT IN THE FIRST TWO YEARS OF LIFE

PENN STATE'S CYBERCORPS; SCHOLARSHIP FOR SERVICE PROGRAM

DOE/PSU GRADUATE STUDENT FELLOWSHIP PROGRAM FOR HYDROPOWER RESEARCH

THE PURPOSE OF THIS AWARD IS TO ADDRESS GAPS IN SURVEILLANCE AND INVESTIGATION ACTIVITIES FOR SARS-COV-2 IN ANIMALS, INCLUDING FARMED ANIMALS, CAPTIVE WILDLIFE, FREE-RANGING WILDLIFE, AND COMPANION ANIMALS. FIRST, WE WILL FILL GAPS IN SURVEILLANCE USING A MODEL INFORMED PROCESS THAT ALLOWS US TO DISTINGUISH BETWEEN DEAD-END  HOSTS AND HOSTS RESPONSIBLE FOR VIRAL AMPLIFICATION AND ONWARD TRANSMISSION BOTH WITHIN AND BETWEEN SPECIES. THESE KEY HOSTS ARE LIKELY INVOLVED IN SYLVATIC TRANSMISSION CHAINS, WHICH WOULD PROMOTE VIRAL PERSISTENCE. SECOND, WE WILL DEMONSTRATE INTERSPECIES TRANSMISSION AND IDENTIFY TRANSMISSION HETEROGENEITIES THAT INCREASE THE VALUE OF THE BASIC REPRODUCTION NUMBER (R0) VIA TARGETED LONGITUDINAL SAMPLING AT WHITE-TAILED DEER PENS, WHICH WE EXPECT TO BE TRANSMISSION HOTSPOTS. THIRD, WE WILL DETERMINE TRANSMISSION DIRECTIONALITY AND THE DEGREE TO WHICH VIRUSES CIRCULATING IN NON-HUMAN ANIMALS ARE MIXING WITH THE VIRAL POPULATIONS OF HUMANS AND VICE VERSA.  THE RECIPIENT MUST MEET THE OBJECTIVES AND DELIVERABLES STATED IN THEIR WORK PLAN AND MUST COMPLETE QUARTERLY FINANCIAL AND PERFORMANCE REPORTS AND A FINAL ACCOMPLISHMENT REPORT. WHOLE-GENOME SEQU ENCES DEPOSITED IN GSAID WILL FOSTER DEVELOPMENT OF MORE COMPREHENSIVE DIAGNOSTICS AND PHARMACEUTICALS, THERAPEUTICS AND VACCINES. FURTHER END-USER BENEFIT COMES IN THE FORM OF MANY UNDERGRADUATE RESEARCHERS AND MINORITY FEMALE POST DOCTORAL SCHOLARS GAINING VALUABLE FIELD ECOLOGY EXPERIENCE AS WELL AS EPIDEMIOLOGICAL SKILLS IN THE LAB. THE OVERALL GOAL IS TO SAFEGUARD THE HEALTH OF THE HUMAN POPULATION, WILDLIFE AND AGRICULTURAL SYSTEMS. SUBCONTRACTS INCLUDE GINKGO BIOWORKS FOR $996,585 (GINKGO WILL ACCOMPLISH THE SEQUENCING FOR ALL OBJECTIVES BECAUSE IT IS THEIR SPECIALTY AND THEY HAVE SEQUENCED >40,000 SARS COV-2 WHOLE GENOMES FOR STATE AND FEDERAL PUBLIC HEALTH STAKEHOLDERS, INCLUDING THE CENTERS FOR DISEASE CONTROL AND PREVENTION (CDC).) AND XAVIER DIDELOT AT WARWICK UNIVERSITY FOR $15,596 (XAVIER WILL ACCOMPLISH THE TRANSPHYLO ANALYSIS OF THE SEQUENCE DATA FROM ALL THREE OBJECTIVES BECAUSE HE DEVELOPED THE PROGRAM AND IS THE LEADER IN THIS NEW AND BLOSSOMING FIELD OF TRANSMISSION RECONSTRUCTION.)

REGULATION OF DNA DAMAGE INDUCED GENES BY YEAST TAFIIS

PURPOSE: THE NATIONAL SEA GRANT COLLEGE PROGRAM WAS ESTABLISHED BY THE U.S. CONGRESS IN 1966 (AMENDED IN 2008, PUBLIC LAW 110-394) TO BE A HIGHLY LEVERAGED FEDERAL AND STATE PARTNERSHIP TO HARNESS THE INTELLECTUAL CAPACITY OF THE NATION'S UNIVERSITIES AND RESEARCH INSTITUTIONS TO SOLVE PROBLEMS AND GENERATE OPPORTUNITIES IN COASTAL COMMUNITIES. FOR OVER 50 YEARS, THE NATIONAL SEA GRANT COLLEGE PROGRAM HAS SUPPORTED COASTAL AND GREAT LAKES COMMUNITIES THROUGH RESEARCH, EXTENSION AND EDUCATION. SEA GRANT'S MISSION IS TO ENHANCE THE PRACTICAL USE AND CONSERVATION OF COASTAL, MARINE AND GREAT LAKES RESOURCES TO CREATE A SUSTAINABLE ECONOMY AND ENVIRONMENT. THIS GRANT IS THE VEHICLE THROUGH WHICH PENNSYLVANIA SEA GRANT LAYS OUT ITS PLAN TO IMPLEMENT THE GOALS DESCRIBED IN THEIR FY2024-27 STRATEGIC PLAN, WHICH CAN BE FOUND AT: HTTPS://SEAGRANT.NOAA.GOV/INSIDESEAGRANT/PLANNING. IN ADDITION TO REQUIRED GRANT PROGRESS REPORTING, THE RECIPIENT WILL REPORT DEFINED MEASURES AND METRICS AS WELL AS SUCCESS STORIES ANNUALLY AND WILL BE EVALUATED ON PERFORMANCE DURING A SITE REVIEW EXPECTED IN 2028 OR 2029. ACTIVITIES TO BE PERFORMED: EACH UNIVERSITY-BASED SEA GRANT PROGRAM CONTRIBUTES TO THE NATIONAL FOCUS AREAS AND GOALS, AND PENNSYLVANIA SEA GRANT IS NO DIFFERENT, ALIGNING THEIR FOCUS AREAS WITH THE NATIONAL SEA GRANT STRATEGIC PLAN'S FOCUS AREAS OF: HEALTHY COASTAL ECOSYSTEMS, SUSTAINABLE FISHERIES AND AQUACULTURE, RESILIENT COMMUNITIES AND ECONOMIES, AND ENVIRONMENTAL LITERACY AND WORKFORCE DEVELOPMENT. ACTIVITIES WITHIN EACH OF THESE FOCUS AREAS INCLUDE RESEARCH, EXTENSION, AND EDUCATIONAL PROJECTS THAT AIM TO FURTHER THE NATIONAL SEA GRANT COLLEGE PROGRAM'S STATED MISSION. EXPECTED OUTCOMES: NOAA PROVIDES FUNDING TO SEA GRANT INSTITUTIONS TO INCREASE THE UNDERSTANDING, ASSESSMENT, DEVELOPMENT, MANAGEMENT, UTILIZATION, AND CONSERVATION OF THE NATION'S OCEAN, COASTAL, AND GREAT LAKES RESOURCES. THESE IMPORTANT EFFORTS PROMOTE A STRONG EDUCATIONAL BASE, RESPONSIVE RESEARCH AND TRAINING ACTIVITIES, BROAD AND PROMPT DISSEMINATION OF KNOWLEDGE AND TECHNIQUES, AND MULTIDISCIPLINARY APPROACHES TO ENVIRONMENTAL PROBLEMS, IN ACCORDANCE WITH 33 U.S.C. 1121(B). SPECIFIC OUTCOMES IDENTIFIED BY THE RECIPIENT INCLUDE, BUT ARE NOT LIMITED TO: ENGAGE AN ECOSYSTEM APPROACH TO WATERSHED MANAGEMENT OF THE COMMONWEALTH'S COASTAL RESOURCES, FOCUSING ON THE LAKE ERIE, DELAWARE, AND SUSQUEHANNA WATERSHEDS. CAPITALIZE ON THE INTELLECTUAL AND PHYSICAL RESOURCES OF PENNSYLVANIA'S COLLEGES AND UNIVERSITIES TO FURTHER PENNSYLVANIA SEA GRANT RESEARCH AND COLLABORATIVE EFFORTS. COLLABORATE WITH PARTNER ORGANIZATIONS AND SEEK NEW PARTNERSHIPS THAT BUILD ON PENNSYLVANIA SEA GRANT'S STRENGTH. SERVE AS A LOCAL RESOURCE TO SUPPORT AND DISSEMINATE FINDINGS AND RESOURCES OF NOAA AND OTHER PARTNER ORGANIZATIONS. ADVANCE INNOVATIVE SOLUTIONS THAT ADDRESS EMERGING CHALLENGES AND ENCOURAGE CREATIVITY, INITIATIVE, AND INNOVATION. BE RESPONSIVE AND ACCESSIBLE, RESPECT PARTNERS, MAINTAIN SCIENTIFIC NEUTRALITY, INTEGRATE DIVERSE EXPERTISE, AND PROVIDE THE SCIENCE AND KNOWLEDGE NEEDED TO INFORM STAKEHOLDERS. COMMUNICATE THE IMPORTANCE OF STEWARDSHIP AND THE VALUE OF THE SERVICES THAT THE COASTAL, OCEAN, AND GREAT LAKES' ECOSYSTEMS PROVIDE TO THE NATION. PROMOTE DIVERSITY, EQUITY, AND INCLUSION PRINCIPLES THAT INCREASE THE BREADTH OF SERVICES AND OPPORTUNITIES TO UNDERSERVED AND UNDERREPRESENTED INDIVIDUALS AND COMMUNITIES INTENDED BENEFICIARIES: RESIDENTS, STAKEHOLDERS, AND DECISION-MAKERS OF THE STATE OF PENNSYLVANIA AS WELL AS THROUGHOUT THE GREAT LAKES AND MID-ATLANTIC REGIONS. SUBRECIPIENT ACTIVITIES: THE RECIPIENT PLANS TO SUBAWARD FUNDS TO PRINCIPAL INVESTIGATORS THROUGHOUT THE STATE OF PENNSYLVANIA WHO SUCCESSFULLY COMPETED FOR FUNDING ACCORDING TO THE NATIONAL SEA GRANT COLLEGE PROGRAM'S COMPETITION POLICY. ADDITIONALLY, FUNDING MAY BE SUBAWARDED FOR EXTENSION OR EDUCATION WORK.

MAPPING THE STRUCTURAL BASIS FOR MECHANISTIC DIVERSITY IN METALLOENZYME SUPERFAMILIES

GENES, PRENATAL DRUG EXPOSURE, AND THE POSTNATAL ENVIRONMENT: AN ADOPTION STUDY

GRADUATE RESEARCH FELLOWSHIP PROGRAM

PENNSYLVANIA SEA GRANT 2014-2018 OMNIBUS PROGRAM

DECIPHERING EARLY STAGES OF POLYOMAVIRUS CNS PATHOGENESIS AND IMMUNITY - ABSTRACT JC POLYOMAVIRUS (JCPYV), A UBIQUITOUS HUMAN PATHOGEN, CAUSES SEVERAL DEVASTATING BRAIN DISEASES IN IMMUNE COMPROMISED INDIVIDUALS. THE MOST NOTABLE OF THESE JCPYV-ASSOCIATED CNS DISEASES IS THE FREQUENTLY FATAL DEMYELINATING BRAIN DISEASE PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY (PML). PML, AN AIDS-DEFINING LESION IN THE PRE-CART EPOCH, HAS EMERGED AS A LIFE-THREATENING COMPLICATION IN PATIENTS RECEIVING IMMUNOMODULATORY AGENTS FOR AUTOIMMUNE AND INFLAMMATORY DISORDERS AND TREATMENT FOR CERTAIN HEMATOLOGICAL MALIGNANCIES. AMONG THE RAPIDLY EXPANDING LIST OF PML-ASSOCIATED BIOLOGICS, NATALIZUMAB (TYSABRI®) HAS THE HIGHEST INCIDENCE AND IS AN OMINOUS SEQUELA FOR MULTIPLE SCLEROSIS (MS) PATIENTS WHO OTHERWISE BENEFIT FROM DRAMATIC REDUCTIONS IN RELAPSES USING THIS IMMUNOMODULATORY AGENT. DRUG WITHDRAWAL, THE ONLY THERAPEUTIC OPTION FOR PML, IS OFTEN COMPLICATED BY A HIGH-MORTALITY CEREBRAL INFLAMMATORY REACTION. NO ANTI-JCPYV AGENTS ARE AVAILABLE. POLYOMAVIRUSES ARE SPECIES-SPECIFIC. LACK OF A TRACTABLE ANIMAL MODEL OF POLYOMAVIRUS-INDUCED CNS DISEASE IS AN ACKNOWLEDGED BOTTLENECK TO ELUCIDATING PML PATHOGENESIS, THE IMMUNOLOGICAL MECHANISMS THAT CONTROL JCPYV, IN VIVO EVALUATION OF AGENTS THAT INHIBIT POLYOMAVIRUS REPLICATION IN TISSUE CULTURE, AND UNCOVERING EARLY EVENTS THAT PRESAGE IRREVERSIBLE JCPYV-ASSOCIATED NEUROPATHOLOGY. USING MOUSE POLYOMAVIRUS (MUPYV), WE DEVELOPED A NATURAL VIRUS-HOST MODEL OF POLYOMAVIRUS-ASSOCIATED CNS DISEASE. IN THIS R35 APPLICATION, WE PLAN TO LEVERAGE OUR THREE RECENT KEY FINDINGS: (1) MAPPING JCPYV-PML VP1 CAPSID PROTEIN MUTATIONS TO MUPYV’S VP1 CONFERS ESCAPE FROM VIRUS- NEUTRALIZING ANTIBODIES (NAB) WHILE PRESERVING CNS TROPISM; (2) IL-21 PRODUCED BY HIGH-AFFINITY ANTI-MUPYV CD4 T CELLS IN THE BRAIN IS REQUIRED FOR FORMATION AND MAINTENANCE OF MUPYV-SPECIFIC BRAIN RESIDENT-MEMORY CD8 T CELLS (BTRM); AND (3) STAT1-DEPENDENT INNATE IMMUNITY LIMITS INFECTION OF THE VENTRICULAR EPENDYMA, A CRITICAL BARRIER TO INFECTION OF THE BRAIN PARENCHYMA. THESE FINDINGS LAY THE FOUNDATION FOR THREE KEY QUESTIONS TO BE ADDRESSED HERE: (1) IS THE EPENDYMA THE STAGING GROUND FOR POLYOMAVIRUS INVASION OF THE BRAIN PARENCHYMA?; (2) DOES THE INTEGRITY OF THE CD8 BTRM RESPONSE TO PERSISTENT INFECTION DEPEND ON SUBSET HETEROGENEITY?; AND (3) DOES T CELL DEFICIENCY OPEN THE DOOR FOR OUTGROWTH OF NAB-ESCAPE VIRUS VARIANTS? THE PROPOSED STUDIES WILL MAKE USE OF CUTTING EDGE ADVANCES IN NEXT-GENERATION SEQUENCING TO UNCOVER RARE VP1 MUTATIONS IN VIVO, CUSTOM CRYO EM IMAGE RECONSTRUCTION APPROACHES TO DEFINE ENDOGENOUS VP1 NAB EPITOPES AND NAB ESCAPE MECHANISMS, AND HIGH-RESOLUTION 3D IMAGING OF INTACT MOUSE BRAINS TO VISUALIZE VIRUS CNS ENTRY AND SPREAD. FINDINGS FROM THESE STUDIES WILL ANSWER FUNDAMENTAL QUESTIONS ABOUT INNATE AND ADAPTIVE IMMUNE CONTROL OF POLYOMAVIRUS CNS INFECTION AND CONDITIONS UNDERLYING DISSEMINATION OF VIRUS FROM THE PERIPHERY INTO THE BRAIN BEFORE DEVELOPMENT OF IRREVERSIBLE NEUROPATHOLOGY.

THE PENNSYLVANIA SPACE GRANT CONSORTIUM (PSGC) OFFERS PROGRAMS AND PROJECTS IN SUPPORT OF NASA PRIORITIES ALIGNED WITH THE PRIORITIES OF MISSION DIRECTORATES AND THE GOALS OF THE NATIONAL SPACE GRANT COLLEGE AND FELLOWSHIP PROGRAM...