University Of Wyoming

WYOMING IDEA NETWORKS OF BIOMEDICAL RESEARCH EXCELLENCE

THE SWEETWATER CARBON STORAGE HUB (SCS HUB) WILL CAPTURE AND STORE CARBON FROM THE LARGEST PROPOSED DIRECT AIR CAPTURE (DAC) FACILITY IN THE ROCKY MOUNTAINS AND ONE OF THE NATION’S LARGEST TRONA (SODA ASH) MINES. THE PROJECT HAS FOUR OBJECTIVES: 1) BUILD THREE STRATIGRAPHIC CHARACTERIZATION WELLS TO UNDERGROUND INJECTION CONTROL (UIC) CLASS VI SPECIFICATIONS, WITH ATTENDANT PERMITTING AND SITE CHARACTERIZATION WHILE OBSERVING THE BUY AMERICA REQUIREMENTS FOR INFRASTRUCTURE PROJECTS, 2) COMPLETE CAPTURE & TRANSPORT STUDIES FOR TWO CARBON DIOXIDE (CO2) SOURCES (DAC & TRONA) AND THE PIPELINES TO CONNECT THESE SOURCES TO THE STORAGE HUB, 3) PREPARE COMMERCIAL PLANS TO GUIDE FUTURE WORK AND EVENTUAL OPERATIONS, SUCH AS RISK ASSESSMENT AND MITIGATION PLANS, A STORAGE FIELD DEVELOPMENT PLAN (SFDP), AND A COMMUNITY BENEFITS PLAN, AND, 4) COMPLETE A NATIONAL ENVIRONMENTAL POLICY ACT (NEPA) ANALYSES.

ASPHALT RESEARCH CONSORTIUM

GAINING EARLY AWARENESS AND READINESS FOR UNDERGRADUATE PROGRAMS (GEAR UP STATE)

GEAR UP WYOMING GRANT PROPOSAL UNDER FY2017 APPLICATION FOR GU STATE GRANTS

WYOMING SENSORY BIOLOGY COBRE

RII TRACK-1: LINKING MICROBIAL LIFE TO ECOSYSTEM SERVICES ACROSS WYOMING'S DYNAMIC LANDSCAPE

WATER IN A CHANGING WEST: THE WYOMING CENTER FOR ENVIRONMENTAL HYDROLOGY AND GEOPHYSICS

UNIVERSITY OF WYOMING CARES ACT HIGHER EDUCATION EMERGENCY RELIEF FUND - INSTITUTIONAL COSTS

WYOMING KING AIR AS A NATIONAL FACILITY

WYOMING CARBONSAFE: ACCELERATING CCUS COMMERCIALIZATION AND DEPLOYMENT AT DRY FORK POWER STATION AND THE WYOMING INTEGRATED TEST CENTER

RII TRACK-1: ANTICIPATING THE CLIMATE-WATER TRANSITION AND CASCADING CHALLENGES TO SOCIO-ENVIRONMENTAL SYSTEMS IN AMERICA'S HEADWATERS -THE ANTICIPATING THE CLIMATE-WATER TRANSITION AND CASCADING CHALLENGES TO SOCIO-ENVIRONMENTAL SYSTEMS IN AMERICA'S HEADWATERS (WY-ACT) PROJECT WILL BRING TOGETHER RESEARCHERS FROM ACROSS WYOMING TO ADDRESS CRITICAL WATER RESOURCE CHALLENGES ARISING FROM CLIMATE CHANGE IN WYOMING AND THE ROCKY MOUNTAIN REGION. RESEARCHERS WILL IDENTIFY CHALLENGES, QUANTIFY RISKS, AND PREDICT SOCIETAL CONSEQUENCES OF SHIFTING CLIMATE CONDITIONS IN THE NATION?S CRITICAL HEADWATER AREAS, LIMITED BY UNCERTAINTIES IN HOW HYDROLOGICAL, ECOLOGICAL, AND SOCIOLOGICAL SYSTEMS INTERACT. WYOMING PROVIDES THE PREFECT SYSTEM TO STUDY THESE CLIMATE UNCERTAINTIES DUE TO ITS MOUNTAINOUS ECOSYSTEMS THAT LINK HIGH-ELEVATION NATIONAL PARKS AND OTHER FEDERAL LANDS TO A MOSAIC OF LOWER-ELEVATION TRIBAL, STATE, FEDERAL, AND PRIVATE LANDS AND WATERS. THE PROJECT IS DESIGNED TO CREATE SOLUTIONS TO STRAINS ON WATER AVAILABILITY RESULTING FROM CLIMATE CHANGE BY BUILDING TRUSTED NETWORKS WITH COMMUNITIES WHO WILL HAVE OPPORTUNITIES TO PROVIDE INPUT AS WELL AS HELP THE PROJECT TEAM FORMULATE OUTCOMES. THE PROJECT WILL PROVIDE SIGNIFICANT OPPORTUNITIES TO ENGAGE WYOMING COMMUNITIES IN STEM EDUCATION AND DEVELOP SIGNIFICANT COMPUTATIONAL RESOURCES FOR THE STATE. WY-ACT WILL BE ADMINISTERED BY THE UNIVERSITY OF WYOMING IN COLLABORATION WITH CENTRAL WYOMING COLLEGE AND WESTERN ECOSYSTEM TECHNOLOGY, A PRIVATE COMPANY. THE ANTICIPATING THE CLIMATE-WATER TRANSITION AND CASCADING CHALLENGES TO SOCIO-ENVIRONMENTAL SYSTEMS IN AMERICA'S HEADWATERS (WY-ACT) PROJECT WILL CREATE A WORLD-CLASS RESEARCH AND STEM TRAINING FACILITY THAT WILL ADDRESS CRITICAL WATER RESOURCE CHALLENGES ARISING FROM CLIMATE CHANGE IN WYOMING AND THE ROCKY MOUNTAIN REGION. WY-ACT?S GOALS ARE TO: 1) IDENTIFY CLIMATE-DRIVEN RISKS TO INTERACTING HYDROLOGICAL, ECOLOGICAL AND SOCIAL SYSTEMS; 2) REVEAL OPPORTUNITIES AND LIMITS FOR HOW COMMUNITIES AND STAKEHOLDERS RESPOND TO CLIMATE-INDUCED RISKS; 3) EVALUATE HOW THE PROCESS OF CO-PRODUCTION ENHANCES ADAPTIVE CAPACITY FOR KEY STAKEHOLDERS BY BUILDING TRUST IN NUMERICAL MODELS; AND 4) INTEGRATE THE UNDERSTANDING AND QUANTIFICATION OF RISKS AND UNCERTAINTIES ACROSS CLIMATE, HYDROLOGICAL, ECOLOGICAL, AND SOCIAL SYSTEMS THAT ARE INFORMED BY MODELS, OBSERVATIONS, AND STAKEHOLDER COLLABORATION. THESE PROJECT GOALS WILL BE ACHIEVED BY A TRANSDISCIPLINARY APPROACH THAT INCLUDES SOCIAL SCIENCE, CLIMATE SCIENCE, ECONOMICS, HYDROLOGY, DATA SCIENCE, ECOLOGY, AND COMMUNICATION. ADDITIONALLY, THIS PROJECT RECOGNIZES THE VALUE OF INVOLVING TRIBAL NATIONS IN CO-PRODUCTION, AND WILL INCLUDE INDIGENOUS KNOWLEDGE, PRACTITIONER KNOWLEDGE, EXPERIENTIAL KNOWLEDGE, AND SCIENTIFIC WAYS OF UNDERSTANDING TO INFORM AND ENHANCE THE UNDERSTANDING OF CHANGING WATER AVAILABILITY AND ITS IMPLICATIONS. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

UNIVERSITY OF WYOMING - CARES ACT: HIGHER EDUCATION EMERGENCY RELIEF FUND

MID-SCALE RI-1 (M1:IP): THE NEXT GENERATION WYOMING KING AIR ATMOSPHERIC RESEARCH AIRCRAFT

TAS::89 0211::TAS RECOVERY ACT: SITE CHARACTERIZATION OF PROMISING GEOLOGIC FORMATIONS FOR CO2 STORAGE NEW AWARD ENTITLED: RECOVERY ACT: SITE CHARAC

NUTRIENT RESTRICTION: PLACENTAL AND FETAL BRAIN AND RENAL OUTCOMES AND MECHANISM

UW NORTHERN ROCKIES REGIONAL INBRE

WYOMING KING AIR AS A NATIONAL FACILITY

WYOMING KING AIR AS A NATIONAL FACILITY

DE-FE0031624 FOR NEW AWARD ENTITLED COMMERCIAL-SCALE CARBON STORAGE COMPLEX FEASIBILITY STUDY AT DRY FORK STATION, WYOMING

THIS PROJECT WILL CONDUCT A FEASIBILITY ASSESSMENT OF THE TECHNICAL AND NON-TECHNICAL ASPECTS OF AN INTEGRATED CARBON CAPTURE AND STORAGE (CCS) PROJECT AT A SITE ADJACENT TO THE ECHO SPRINGS GAS PLANT IN CARBON COUNTY, WYOMING (THE PLANNED STORAGE FACILITY IS LOCATED NEAR THE BORDER OF CARBON AND SWEETWATER COUNTIES).

HERMISTON OREGON BASALT CARBON STORAGE ASSURANCE FACILITY ENTERPRISE THE PRIMARY OBJECTIVE OF THE HERMISTON OREGON BASALT CARBON STORAGE ASSURANCE FACILITY ENTERPRISE PROJECT IS TO ADDRESS RESEARCH GAPS CRUCIAL TO DE-RISKING AND DEMONSTRATING COMMERCIAL SCALE BASALT-HOSTED CARBON STORAGE, AND TO PROVIDE CRITICAL INFORMATION TO KEY STAKEHOLDERS AND DEVELOPERS SEEKING CARBON DIOXIDE STORAGE OPPORTUNITIES IN THE PACIFIC NORTHWEST OF THE UNITED STATES AND BEYOND.

GEAR UP WYOMING GRANT PROPOSAL UNDER FY2024 APPLICATION FOR GU STATE GRANTS.

DE-FE0031787 / BASE AWARD ''FIELD PILOT OF FOAM ASSISTED HYDROCARBON GAS INJECTION IN BAKKEN FORMATIONS'' UNIVERSITY OF WYOMING

NEW AWARD DE-FE0031779 WITH UNIVERSITY OF WYOMING TITLED UNLOCKING THE TIGHT OIL RESERVOIRS OF THE POWDER RIVER BASIN, WYOMING

GAINING EARLY AWARENESS AND READINESS FOR UNDERGRADUATE PROGRAMS (GEAR-UP) - GEAR-UP STATE AWARD

HEALTH CENTER PROGRAM

METHODS DEVELOPMENT: DEVELOP AND VALIDATE DIAGNOSTIC TESTS FOR SARS-COV-2 AND OTHER CORONAVIRUSES IN WILDLIFE.

ART: RE-ENGINEERING TECHNOLOGY TRANSFER AT THE UNIVERSITY OF WYOMING -WYOMING IS A RURAL STATE WITH POPULATION DENSITY OF LESS THAN 6 PER SQUARE MILE. ITS ECONOMY IS HEAVILY DEPENDENT ON EXTRACTIVES, AGRICULTURE, AND TOURISM. THE UNIVERSITY OF WYOMING (UW) ? THE SOLE UNIVERSITY AND ACADEMIC RESEARCH INSTITUTION IN THE STATE ? HAS $139 MILLION IN RESEARCH EXPENDITURES IN 2022. BUT, BY ALL MARKERS, TRANSLATION OF RESEARCH LAGS IN COMPARISON WITH PEER UNIVERSITIES. BECAUSE UW IS THE STATE?S ONLY ACADEMIC RESEARCH ENTERPRISE, THE CREATION OF THE WYOMING TRANSLATION RESEARCH ACCELERATOR (WTRA) THROUGH THIS AWARD REPRESENTS A UNIQUE OPPORTUNITY FOR FEDERAL INVESTMENT TO IMPACT AN ENTIRE STATE. IT WILL TRANSFORM TRADITIONAL RESEARCH AND COMMERCIALIZATION INTO A HOLISTIC ACCELERATOR OF USE-INSPIRED RESEARCH AND DEVELOPMENT. THE PROJECT WILL DELIVER BENEFITS TO UNDER-SERVED POPULATIONS, AS WELL AS INDUSTRY AND COMMUNITY PARTNERS. EXPECTED OUTCOMES INCLUDE AN INCREASE IN INDUSTRY COLLABORATIONS AND STARTUPS, DIVERSIFICATION OF THE STATE?S ECONOMY, AND GREATER PREPAREDNESS OF GRADUATE STUDENTS AND POST-DOCTORAL STUDENTS TO ENTER INDUSTRY. THIS ART PROJECT WILL CATALYZE UNIVERSITY-WIDE CHANGE TO FOSTER AND SPEED UP THE PACE OF RESEARCH-ENABLED INNOVATION. THE EFFORT IS SUPPORTED AT THE HIGHEST LEVELS OF LEADERSHIP: UW?S PRESIDENT AND VP FOR RESEARCH SERVE AS CO-PRINCIPAL INVESTIGATORS. THIS PROJECT LEVERAGES THE NSF I-CORPS? MODEL, EXPANDING ON ITS PRINCIPLES TO RE-ENGINEER THE EXISTING RESEARCH AND COMMERCIALIZATION ENTERPRISE. EXPERIENTIAL TRAINING WILL BE CONDUCTED, WITH AN EMPHASIS ON GRADUATE STUDENTS AND POST-DOCTORAL RESEARCHERS. SEED TRANSLATIONAL RESEARCH PROJECTS WILL BE SELECTED TO HELP DIVERSIFY AND GROW THE WYOMING ECONOMY. WTRA WILL DEVELOP A MARKET-DRIVEN APPROACH THAT SUPPLANTS THE TRADITIONAL ?MARKET PUSH? MODEL. BASIC RESEARCH WILL STILL FLOURISH, BUT WITH AN EYE TO SOCIETAL BENEFITS BEYOND SCHOLARLY PUBLICATIONS. THIS PROJECT IS JOINTLY FUNDED BY THE TECHNOLOGY, INNOVATION, AND PARTNERSHIPS (TIP) DIRECTORATE, THE ESTABLISHED PROGRAM TO STIMULATE COMPETITIVE RESEARCH (EPSCOR), THE ADVANCE PROGRAM IN THE EDU DIRECTORATE, BIO, AND ENG DIRECTORATES. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

PURPOSE: OVER THE LAST 9 MONTHS, NWRC HAS MADE SIGNIFICANT PROGRESS IN EXPANSION OF LABORATORY CAPACITY FOR MICROBIAL DIAGNOSTICS. CONTINUATION OF SUPPORT WILL ENSURE NWRC'S RECENTLY IMPROVED LABORATORY CAPACITY AND DIAGNOSTIC CAPABILITIES REMAIN FULLY FU

RII TRACK-2 FEC: HIGHLY PREDICTIVE, EXPLANATORY MODELS TO HARNESS THE LIFE SCIENCE DATA REVOLUTION

NEUROSCIENCE CENTER FOR BIOMEDICAL RESEARCH EXCELLENCE

TAS::89 0222::TAS; NEW; WYOMING DOE EPSCOR: QUANTUM DOT SENSITIZED SOLAR CELLS BASED ON TERNARY METAL OXIDE NANOWIRES; PI - THOMAS R. PARISH

AGROECOLOGICAL ANNOTATION OF GENE FUNCTION AND COMPUTATIONAL ANALYSIS OF GENE NETWORKS

ATMOSPHERE TO GRID: ADDRESSING BARRIERS TO ENERGY CONVERSION AND DELIVERY

EXPANDQISE: TRACK 2: DEVELOPING RESEARCH AND EDUCATION PROGRAMS IN QUANTUM INFORMATION SCIENCE AND ENGINEERING WITH RESEARCH ON LOCALLY TUNABLE 2D TOPOLOGICAL SUPERCONDUCTORS -NON-TECHNICAL DESCRIPTION: IN RECENT YEARS, REMARKABLE PROGRESS HAS BEEN MADE IN QUANTUM INFORMATION SCIENCE AND ENGINEERING (QISE), PARTICULARLY FOR QUANTUM COMPUTING, QUANTUM SENSING, QUANTUM COMMUNICATIONS AND QUANTUM SIMULATIONS. WITH THE RAPIDLY EXPANDING INTEREST AND INVESTMENT, EDUCATION AND WORKFORCE DEVELOPMENT EFFORTS IN QISE ARE BECOMING INCREASINGLY CRITICAL, PARTICULARLY IN THE COUNTRY'S RURAL REGIONS. THIS FIVE-YEAR PROJECT IS DESIGNED TO DEVELOP RESEARCH AND EDUCATION CAPACITIES IN THE EMERGING FIELD OF QISE AT THE UNIVERSITY OF WYOMING THROUGH CLOSE COLLABORATION WITH PURDUE UNIVERSITY, WHERE QISE RESEARCH AND EDUCATION PROGRAMS ARE ESTABLISHED AND PRODUCTIVE. THIS PROJECT CONTAINS TWO ESSENTIAL COMPONENTS: 1) CONDUCTING A CUTTING-EDGE RESEARCH PROJECT OF EXPLORING EXOTIC PROPERTIES (FOR EXAMPLE, TOPOLOGICAL SUPERCONDUCTIVITY) OF TWO-DIMENSIONAL (2D) QUANTUM MATERIALS FOR NEXT-GENERATION QUANTUM COMPUTERS; AND 2) DEVELOPING EDUCATION PROGRAMS AT BOTH UNDERGRADUATE AND GRADUATE LEVELS FOR FUTURE WORKFORCE IN QISE AT THE UNIVERSITY OF WYOMING. THIS COLLABORATIVE EFFORT IS EXPECTED TO BREAK THE EXISTING BARRIER, INCREASE PARTICIPATION, AND BUILD THE CRITICAL MASS OF RESEARCH AND EDUCATION IN QISE IN WYOMING, THUS MAINTAINING ITS ECONOMIC COMPETITIVENESS AND FUELING TRANSFORMATIVE SCIENTIFIC ADVANCEMENT. TECHNICAL DESCRIPTION: DEVELOPING NOVEL QUANTUM TECHNOLOGIES FOR FUTURE ADVANCED COMPUTING HAS BEEN AN URGENT NEED AND A TECHNOLOGY RACE WORLDWIDE. TO MAINTAIN ECONOMIC COMPETITIVENESS, SUSTAIN NATIONAL SECURITY, AND FUEL TRANSFORMATIVE SCIENTIFIC ADVANCEMENT IN A TIME OF RAPIDLY EXPANDING INTEREST AND INVESTMENT IN QISE, RELEVANT EDUCATION AND SUSTAINABLE WORKFORCE DEVELOPMENT EFFORTS ARE BECOMING INCREASINGLY CRITICAL. IN COLLABORATION WITH PURDUE UNIVERSITY, WHERE QISE RESEARCH AND EDUCATION PROGRAMS ARE ESTABLISHED AND PRODUCTIVE, A TEAM FROM THE UNIVERSITY OF WYOMING IS UNDERTAKING THIS IMPORTANT AND CRITICAL TASK. THIS COLLABORATIVE ACTIVITY DEVELOPS METHODOLOGIES TO MANIPULATE THE COUPLING BETWEEN ELECTRONIC, STRUCTURAL, AND TOPOLOGICAL DEGREES OF FREEDOM IN ATOMICALLY THIN TOPOLOGICAL SUPERCONDUCTORS AND TO DESIGN AND FABRICATE NOVEL TOPOLOGICAL JOSEPHSON JUNCTION ARCHITECTURES FOR FUTURE FAULT-TOLERANT TOPOLOGICAL QUANTUM COMPUTING. THEORETICAL ANALYSIS AND MODELING FURTHER ENABLE THE FUNDAMENTAL UNDERSTANDING OF THE PHYSICS OF TOPOLOGICAL SUPERCONDUCTIVITY AND MAJORANA FERMIONS AT THE 2D LIMIT. THIS COLLABORATIVE PROJECT ALSO ESTABLISHES THE NECESSARY INFRASTRUCTURES FOR DEVELOPING THE FUTURE WORKFORCE IN QISE AT THE UNIVERSITY OF WYOMING BY DEVELOPING NEW DEGREE PROGRAMS AT BOTH THE UNDERGRADUATE AND GRADUATE LEVELS, RECRUITING NEW FACULTY, AND CONSTRUCTING STATE-OF-THE-ART FACILITIES. THE TEAM FURTHER PURSUES MUTUAL INTERACTIONS WITH INDUSTRY AND NATIONAL LABORATORY PARTNERS TO OFFER RESEARCH/EDUCATION OPPORTUNITIES FOR BOTH UNDERGRADUATE AND GRADUATE STUDENTS. THE ACADEMIC DEGREE PROGRAMS AND WORKFORCE DEVELOPMENT PLAN PROVIDE UNIQUE RESEARCH AND EDUCATIONAL EXPERIENCES FOR PHYSICS, CHEMISTRY, MATHEMATICS, AND ELECTRICAL ENGINEERING AND COMPUTER SCIENCE STUDENTS AT THE UNIVERSITY OF WYOMING. THIS COLLABORATIVE EFFORT IS EXPECTED TO SET UP A NATIONAL EDUCATIONAL MODEL FOR EXPANDING QISE-RELATED RESEARCH AND EDUCATION ACTIVITIES IN THE COUNTRY?S RURAL REGIONS AND/OR INSTITUTIONS WITH NO OR UNDERDEVELOPED QISE PROGRAMS. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

INTEGRATION OF PRODUCED WATER THERMAL DESALINATION AND STEAM METHANE REFORMING FOR EFFICIENT HYDROGEN PRODUCTION THE PROJECT WILL DESIGN, BUILD, DEMONSTRATE, AND FIELD-TEST A SUPERCRITICAL WATER DESALINATION AND OXIDATION (SCWDO) UNIT INTEGRATED WITH A STEAM METHANE REFORMING (SMR) UNIT. THE SCWDO USES HEAT TO REMOVE SALTS, METALS, AND ORGANIC MOLECULES FROM PRODUCED WATER FROM OIL AND GAS WELLS AND THEN THE SMR COMBINES THIS PURIFIED WATER WITH METHANE TO PRODUCE HYDROGEN.

WESTERN RESEARCH INSTITUTE (WRI) COOPERATIVE RESEARCH AND DEVELOPMENT PROGRAM FOR FOSSIL ENERGY MODIFICATION 012 THE PURPOSE OF THIS MODIFICATION IS

DOE WRI COOPERATIVE RESEARCH AND DEVELOPMENT PROGRAM FOR FOSSIL ENERGY RELATED RESOURCES

THE PRIMARY GOALS AND MISSION OF THE WYOMING NASA SPACE GRANT CONSORTIUM (WSGC) BASED ON NASA S 2018 STRATEGIC PLAN MISSION DIRECTORATE PRIORITIES AND OFFICE OF STEM ENGAGEMENT GOALS USING EVIDENCE-BASED PRACTICES ARE: 1) TO PROMOTE A STRONG ED

ASPHALT RESEARCH CONSORTIUM

WYOMING SPACE CONSORTIUM

WYOMING NSF EPSCOR RESEARCH INFRASTRUCTURE IMPROVEMENT

CREATING THE FRAMEWORK FOR THE NEXT GENERATION ENERGY EXASCALE EARTH SYSTEM MODEL (E3SM) AT PROCEED (PERTURBED PHYSICS ENSEMBLE REGRESSION OPTIMIZATION CENTER FOR ESM EVALUATION AND DEVELOPMENT)

GERIATRICS WORKFORCE ENHANCEMENT PROGRAM

EQUIPMENT: MRI: TRACK 2 ACQUISITION OF AN ADVANCED INFRASTRUCTURE TO ACCELERATE IMPACT OF AI THROUGH APPLICATIONS AND INNOVATION FOR WYOMING (AI4WY) -THE AI4WY (ACQUISITION OF AN ADVANCED INFRASTRUCTURE TO ACCELERATE IMPACT OF AI THROUGH APPLICATIONS AND INNOVATION FOR WYOMING) PROJECT WILL ACQUIRE A STATE-OF-THE-ART HIGH-PERFORMANCE COMPUTING (HPC) SYSTEM, SIGNIFICANTLY ADVANCING THE APPLICATION AND INNOVATION OF ARTIFICIAL INTELLIGENCE AND COMPUTATIONAL SCIENCE ACROSS THE UNIVERSITY OF WYOMING AND THE ROCKY MOUNTAIN REGION. THE INSTRUMENT WILL ENABLE THE ADOPTION AND DEVELOPMENT OF SCALABLE SCIENTIFIC SOFTWARE FOR ADDRESSING GRAND-CHALLENGE PROBLEMS CHARACTERIZED BY BIG DATA AND INTEGRATED MODELING. THIS INITIATIVE STRIVES TO PROMOTE SCIENTIFIC PROGRESS AND TACKLE PRESSING ISSUES IN FOUR EMPHASIZED RESEARCH DOMAINS WITH REGIONAL AND NATIONAL IMPACT: ENVIRONMENT, AGRICULTURE, SOCIETY, AND ENERGY. BY PROVIDING RESEARCHERS WITH ACCESS TO CUTTING-EDGE COMPUTING RESOURCES, AI4WY FACILITATES GROUNDBREAKING RESEARCH AND EDUCATION, FOSTERING COLLABORATIONS AMONG UNIVERSITIES AND EXPANDING OPPORTUNITIES TO SERVE THE NEEDS OF ALL USERS, INCLUDING THOSE FROM UNDER-SERVED INSTITUTIONS, PROMOTING THE HPC ECOSYSTEM ACROSS THE ROCKY MOUNTAIN REGION. THE AI4WY PROJECT WILL UTILIZE A SPECIALIZED HPC SYSTEM FEATURING NVIDIA DGX GH200 GRACE HOPPER SUPERCHIPS, INTERCONNECTED WITH NVIDIA INFINIBAND AND NVLINK, AND EQUIPPED WITH 400 TERABYTES OF DATA STORAGE. THIS INFRASTRUCTURE ADDRESSES CRITICAL COMPUTING CHALLENGES RELATED TO DATA MOVEMENT AND ENERGY CONSUMPTION THROUGH THE GRACE HOPPER ARCHITECTURE, WHICH INTEGRATES HIGH-BANDWIDTH COHERENT DATA TRANSFERS BETWEEN CPU AND GPU. AI4WY WILL GERMINATE COLLABORATIVE HPC RESEARCH BY SERVING RESEARCHERS AND EDUCATORS AT THE UNIVERSITY OF WYOMING, COLORADO STATE UNIVERSITY (CSU), AND THE ROCKY MOUNTAIN ADVANCED COMPUTING CONSORTIUM (RMACC). THROUGH THIS PROGRAM, THE UNIVERSITY OF WYOMING AND COLORADO STATE UNIVERSITY ARE ACTIVELY ESTABLISHING FORMAL RESEARCH AND TRAINING COLLABORATIONS TO FOCUS ON INTER-STATE RESEARCH PROBLEMS, INCLUDING AGRICULTURE, PUBLIC HEALTH, SOCIETY, ENERGY, AND TOURISM. A DEDICATED ALLOCATION OF 15% OF COMPUTING RESOURCES ON THE PROPOSED INSTRUMENT TO CSU FOR RESEARCH AND TRAINING WILL PROMOTE THESE EFFORTS. MORE BROADLY, THE AI4WY PROJECT WILL ALSO PROVIDE A 10% RESOURCE ALLOCATION TO THE ROCKY MOUNTAIN ADVANCED COMPUTING CONSORTIUM (RMACC), GIVING ACCESS TO 33 INSTITUTIONS IN THE WEST, INCLUDING SOME 45,000 ACADEMIC STAFF, 160,000 GRADUATES AND 540,000 UNDERGRADUATE STUDENTS, AND 15 NON-R1 UNIVERSITIES. THIS PROJECT IS JOINTLY FUNDED BY OFFICE OF INTEGRATIVE ACTIVITIES (OIA), THE ESTABLISHED PROGRAM TO STIMULATE COMPETITIVE RESEARCH (EPSCOR), DIRECTORATE FOR COMPUTER AND INFORMATION SCIENCE AND ENGINEERING (CISE), AND OFFICE OF ADVANCED CYBERINFRASTRUCTURE (OAC). THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

TAS::89 0213::TAS NEW AWARD TO WESTERN RESEARCH INSTITUTE ENTITLED "PILOT SCALE WATER GAS SHIFT - MEMBRANE DEVICE FOR HYDROGEN FROM COAL."

NEUROSCIENCE CORE CENTER

RESEARCH: PREDICTING GENOTYPIC VARIATION IN GROWTH AND YIELD UNDER ABIOTIC STRESS THROUGH BIOPHYSICAL PROCESS MODELING

GERIATRICS WORKFORCE ENHANCEMENT PROGRAM

A SYSTEMS ANALYSIS OF PLANT GROWTH PROMOTION BY THE RHIZOSPHERE MICROBIOME

IN VIVO REGULATION OF THE EXTRACELLULAR MATRIX

GROWING RESILIENCE IN WIND RIVER INDIAN RESERVATION: AN RCT ON GARDENS FOR HEALTH

STATE MATERNAL HEALTH INNOVATION PROGRAM

DEVELOPMENTAL FUNCTION OF RB FAMILY PROTEINS

TAS::89 0213::TAS NEW AWARD ENTITLED MAXIMIZATION OF PERMANENT TRAPPING OF CO2 AND CO-CONTAMINANTS IN THE HIGHEST-POROSITY FORMATIONS OF THE ROCK SPR

COMMUNITY HEALTH WORKER TRAINING PROGRAM - COLLEGE OF HEALTH SCIENCES UNIVERSITY OF WYOMING 1000 E UNIVERSITY AVE LARAMIE, WY 82071 PROJECT DIRECTOR BRYANT SMALLEY, PHD, PSYD, MBA WYOMING EXCELLENCE CHAIR IN RURAL HEALTH 307-766-3495 BSMALLEY@UWYO.EDU $3,000,000 IN GRANT FUNDS REQUESTED DESPITE BEING THE 10TH LARGEST STATE IN THE UNITED STATES, WYOMING IS THE COUNTRY’S LEAST POPULOUS STATE WITH ONLY 578,000 RESIDENTS. CORRESPONDINGLY, EACH OF WYOMING’S COUNTIES IS HRSA-CLASSIFIED AS EITHER ENTIRELY RURAL (21 COUNTIES) OR PARTIALLY RURAL (2 COUNTIES), WITH 70% OF WYOMINGITES LIVING IN RURAL/FRONTIER AREAS. IN ADDITION, WYOMING HAS THE 8TH-HIGHEST REPRESENTATION OF NATIVE AMERICAN RESIDENTS IN THE NATION, WITH THE 7TH-LARGEST RESERVATION IN THE US SERVING AS HOME TO BOTH THE EASTERN SHOSHONE AND NORTHERN ARAPAHO TRIBES. RESIDENTS OF WYOMING FACE COMPLEX CHALLENGES IN RECEIVING ADEQUATE HEALTH CARE. OF WYOMING’S 23 COUNTIES, 19 ARE PRIMARY CARE HPSAS AND WYOMING HAS THE SIXTH-HIGHEST RATE OF UNINSURANCE IN THE NATION. THESE BARRIERS TO CARE RESULT IN CLEAR INEQUITIES, WITH WYOMING RANKING 46TH IN THE NATION FOR PERCENT OF THE POPULATION WITH A DEDICATED HEALTH CARE PROVIDER, AND 49TH IN THE NATION FOR RECEIPT OF ANNUAL IMMUNIZATIONS AND COLORECTAL SCREENINGS. MENTAL HEALTH IS ALSO AN AREA OF HIGH NEED – THE ENTIRE STATE IS CLASSIFIED AS A MENTAL HEALTH HPSA AND WYOMING HAS THE HIGHEST SUICIDE RATE IN THE COUNTRY. THE STATE HAS RECOGNIZED THE CRITICAL ROLE THAT COMMUNITY HEALTH WORKERS (CHWS) CAN PLAY IN ADDRESSING THE HEALTHCARE NEEDS OF ITS RESIDENTS, AND AGENCIES THROUGHOUT WYOMING HAVE WORKED FOR SEVERAL YEARS TO LAY THE GROUNDWORK TO ENACT A ROBUST CHW SYSTEM. PILOT PROGRAMS IN CARBON AND TETON COUNTIES TESTED THE PLACEMENT OF CHWS IN HOSPITAL AND PUBLIC HEALTH DEPARTMENT LOCATIONS AND HAVE SHOWN HIGH PROMISE; HOWEVER, THE LACK OF AVAILABLE CHW TRAINING IN WYOMING REQUIRED INTERESTED CANDIDATES TO BE TRAINED IN TEXAS, RESULTING IN SUBSTANTIAL BARRIERS TO PURSUING A CAREER AS A CHW. CREATING CHW TRAINING INFRASTRUCTURE IN WYOMING WOULD ALLOW THE STATE TO EXPAND UPON ITS MOMENTUM IN CHW TRAINING AND DIRECTLY TARGET HEALTH INEQUITIES. TO ACHIEVE THIS GOAL, WE HAVE ASSEMBLED THE WYOMING COMMUNITY HEALTH WORKER TRAINING CONSORTIUM (WCHWTC), A STATE-WIDE, CROSS-SECTOR GROUP WORKING TO CREATE A ROBUST, SUSTAINABLE CHW TRAINING INFRASTRUCTURE. MEMBERS OF THE CONSORTIUM INCLUDE: UNIVERSITY OF WYOMING COLLEGE OF HEALTH SCIENCES; STATE OF WYOMING DIVISION OF PUBLIC HEALTH; STATE OF WYOMING DEPARTMENT OF WORKFORCE SERVICES; STATE OF WYOMING APPRENTICESHIP EXPANSION PROGRAM; WYOMING PRIMARY CARE ASSOCIATION; WYOMING HOSPITAL ASSOCIATION; EDUCATIONAL HEALTH CENTERS OF WYOMING (FQHC NETWORK); CHEYENNE FAMILY MEDICINE RESIDENCY; CASPER-NATRONA COUNTY HEALTH DEPARTMENT; AND LARAMIE COUNTY COMMUNITY COLLEGE. CHWTP FUNDING WILL ALLOW THE WCHWTC TO: 1) EXPAND THE PUBLIC HEALTH WORKFORCE BY DEVELOPING A STATE-ENDORSED CHW CERTIFICATION PROGRAM DELIVERED BY A NATIONALLY-ACCREDITED HEALTH PROFESSIONS SCHOOL; 2) DELIVER ONGOING LEARNING AND PROFESSIONAL DEVELOPMENT OPPORTUNITIES FOR NEW AND EXISTING CHWS; 3) ENSURE EMPLOYMENT READINESS THROUGH FIELD PLACEMENTS AND REGISTERED APPRENTICESHIPS; AND 4) IMPROVE HEALTH EQUITY AND SUPPORT FOR UNDERSERVED WYOMING COMMUNITIES. TO ACHIEVE THESE GOALS, THE WCHWTC WILL: 1) CREATE A CHW TRAINING PROGRAM DESIGNED TO PREPARE TRAINEES FOR THE UNIQUE HEALTHCARE DYNAMICS OF NATIVE AMERICAN, HISPANIC, AND RURAL/FRONTIER POPULATIONS; 2) DESIGN AND IMPLEMENT A FINANCIAL SUPPORT SYSTEM THAT MITIGATES BARRIERS TO PURSUING CHW CERTIFICATION; 3) RECRUIT, TRAIN, AND CERTIFY AT LEAST 120 CHWS IN WYOMING, WITH AT MINIMUM 75% BEING NEW CHWS; 4) PLACE AT LEAST 120 TRAINED CHWS INTO EXPERIENTIAL TRAINING PROGRAMS, WITH AT LEAST 25% OF NEW TRAINEES ENTERING REGISTERED APPRENTICESHIP PROGRAMS; AND 5) CREATE A SUSTAINABLE INFRASTRUCTURE TO ALLOW THE WCHWTC TO MAINTAIN ITS CORE ACTIVITIES AFTER THE FUNDING PERIOD HAS ENDED

UNIVERSITY OF WYOMING EDUCATIONAL OPPORTUNITY CENTERS - 1 (EOC-1)

THE ENERGY -WATER RESOURCES INTERFACE: A MODEL FOR COMPLEX SYSTEMS ANALYSIS IN RURAL WYOMING MIDDLE SCHOOLS

DE-FE0031738: DEVELOPING CARBON DIOXIDE-ENHANCED OIL RECOVERY AND ASSOCIATED STORAGE WITHIN THE RESIDUAL OIL ZONE FAIRWAYS OF THE POWDER RIVER BASIN WYOMING: NEW AWARD

UNIVERSITY CENTER OF EXCELLENCE IN DEVELOPMENTAL DISABILITIES

PURPOSE: EFFECTIVE APRIL 1, 2022 VIA THIS COOPERATIVE AGREEMENT THIS RECIPIENT WAS GRANTED FUNDING TO OPERATE AN MEP CENTER IN THE STATE OF WYOMING. THE PURPOSE OF THIS AWARD IS TO PROVIDE MANUFACTURING EXTENSION SERVICES TO PRIMARILY SMALL AND MEDIUM-SIZED MANUFACTURERS IN THE STATE OF WYOMING. ACTIVITIES TO BE PERFORMED: THROUGH ITS COLLABORATIONS AT THE FEDERAL, STATE AND LOCAL LEVEL, AS IT EVOLVES TO NIST 2.0, MANUFACTURING-WORKS WILL PURSUE THREE BROAD STRATEGIC APPROACHES:1) ADAPT THE M-W BUSINESS MODEL TO PROVIDE NEW PRODUCTS AND SERVICES, 2) CONTINUE TO PROVIDE TRADITIONAL MEP SERVICES, FOCUSED ON FIVE KEY AREAS, AND 3) LEVERAGE ITS RESOURCES BY ENHANCING CURRENT PARTNERSHIPS AND FOSTERING NEW ONES. THESE THREE APPROACHES HAVE BEEN DEVELOPED BY THE CURRENT TEAM DURING THE PAST YEAR?S TRANSITION PERIOD. GOING FORWARD, M-W WILL CONSULT WITH ITS NEWLY EXPANDED ADVISORY BOARD TO REVIEW AND EXTEND THIS STRATEGY FOR THE LONGER TERM.EXPECTED OUTCOMES: THE CENTER WILL STRENGTHEN MANUFACTURING IN WYOMING BY COMMUNICATING AND DELIVERING/MAKING NEW TECHNOLOGIES AVAILABLE TO MANUFACTURERS FOR GROWTH AND PRODUCTIVITY. THE CENTER BUILDS AWARENESS OF MANUFACTURING CAREERS WITH THEIR PROGRAMS/PRESENTATIONS. PROVIDE SERVICES THAT ADDRESS WORKFORCE BEHAVIORS THAT IMPACT PRODUCTIVITY AND BUSINESS PERFORMANCE ISSUES. THEIR LEADERSHIP DEVELOPMENT AND SUCCESSION PLAN DEVELOPMENT HELPS MANUFACTURERS CONTINUE TO GROW AND BE VIABLE. THE CENTERS GOAL IS TO ASSIST MANUFACTURERS IN THE ACHIEVEMENT OF HIGHER PERFORMANCE AND IMPROVED GLOBAL COMPETITIVENESS. INTENDED BENEFICIARIES: SMALL AND MEDIUM-SIZED MANUFACTURERS IN THE STATE OF WYOMING.SUBRECIPIENT ACTIVITIES: THE RECIPIENT DOES NOT PLAN TO UTILIZE SUBAWARDS TO PARTICIPATE IN CONDUCTING THE ACTIVITIES RELATED TO WORK FORCE DEVELOPMENT AND TECHNICAL ASSISTANCE MANUFACTURER

IMPACT OF FC N-GLYCAN STRUCTURE ON HIV-SPECIFIC ANTIBODY FUNCTIONS

DEVELOPMENTAL PROGRAMMING BY MISMATCH OF PRE-AND POSTNATAL NURTITION

RWO208: MAPPING BIG GAME MIGRATION CORRIDORS IN WYOMING AND OTHER WESTERN STATES: USGS IMPLEMENTATION OF SECRETARIAL ORDER 3362

WYOMING EMPLOYMENT SUPPORT PROJECT (WESP)

THE PRIMA RY MISSION OF THE WYOMING NASA SPACE GRANT CONSORTIUM (WSGC), BASED ON NASA'S STRATEGIC PLAN, LINES OF BUSINESS, AND EDUCATION PRIORITIES,

WYOMING INSTITUTE FOR DISABILITIES: WYOMING'S UNIVERSITY CENTER FOR EXCELLENCE IN DEVELOPMENTAL DISABILITIES EDUCATION,

UNIVERSITY OF WYOMING UPWARD BOUND - 2017

EDUCATIONAL OPPORTUNITY CENTERS PROGRAM

UTILIZING INTRINSICALLY DISORDERED PROTEINS AND COSOLUTES TO INDUCE REVERSIBLE BIOSTASIS IN HUMAN WHOLE BLOOD

PROTEIN EXCHANGE AND SELF RECOGNITION IN MYXOBACTERIA BIOFILMS

MANUFACTURING-WORKS (THE WYOMING MEP)AT THE UNIVERSITY OF WYOMING

THE PRIMARY MISSION OF THE WYOMING NASA SPACE GRANT CONSORTIUM (WSGC), BASED ON NASA'S EDUCATION OUTCOMES, IS: 1) TO PROMOTE A STRONG EDUCATIONAL BA

COLLABORATIVE RESEARCH: CI-WATER, CYBERINFRASTRUCTURE TO ADVANCE HIGH PERFORMANCE WATER RESOURCE MODELING

MECHANISMS OF NUCLEAR SIZE REGULATION

AWARD TYPE: PROJECT GRANT; ACTIVITIES TO BE PERFORMED: PROVIDE HIGH QUALITY SUPPORT AND TECHNICAL ASSISTANCE WITH PANDEMIC RELIEF PROGRAMS AND RECOVERY SERVICES TO SMALL BUSINESSES.; DELIVERABLES: GRANTEES WILL PROVIDE REPORTS ON ACTIVITIES AND PROGRESS TOWARD STATED GOALS TO SBA ON A QUARTERLY BASIS.; EXPECTED OUTCOMES: INCREASE AWARENESS OF AND PARTICIPATION IN PROGRAMS OF THE U.S SMALL BUSINESS ADMINISTRATION AND OTHER GOVERNMENT AGENCIES.; INTENDED BENEFICIARIES: SMALL BUSINESSES AND ENTREPRENEURS THAT FALL INTO A HISTORICALLY UNDERSERVED CATEGORY, INCLUDING MINORITY ENTREPRENEURS (BLACK, INDIGENOUS, AND PEOPLE OF COLOR), ENTREPRENEURS WITH DISABILITIES, LGBTQ ENTREPRENEURS, RURAL ENTREPRENEURS; VETERANS AND MILITARY ENTREPRENEURS (INCLUDING SPOUSES), WOMEN ENTREPRENEURS, INNOVATIVE STARTUPS, MICRO BUSINESSES, AND SOCIALLY AND ECONOMICALLY DISADVANTAGED SMALL BUSINESSES; SUBRECIPIENT ACTIVITIES: GRANTEES (HUBS) AND THEIR CONTRACTORS (SPOKES) WILL PROVIDE HIGH QUALITY SUPPORT AND TECHNICAL ASSISTANCE WITH PANDEMIC RELIEF PROGRAMS AND RECOVERY SERVICES TO SMALL BUSINESSES. THIS SUPPORT TAKES THE FORM OF 1:1 COUNSELING AND GROUP TRAININGS.

DISSEMINATION OF NANOTECHNOLOGIES FOR ENERGY PRODUCTION AND ENVIRONMENT PROTECTION IN RURAL AREAS OF WYOMING

WYOMING KING AIR AS A NATIONAL FACILITY

AMERICAN RESCUE PLAN ACT FUNDING FOR HEALTH CENTERS

UNIVERSITY CENTERS FOR EXCELLENCE IN DEVELOPMENTAL DISABILITIES EDUCATION, RESEARCH AND SERVICE

IMPACT 307

EDUCATIONAL OPPORTUNITY CENTERS PROGRAM

FY 17 WY BIOLOGICAL CONTROL WYOMING WEED

UPWARD BOUND

UNIVERSITY OF WYOMING UPWARD BOUND

UNIVERSITY OF WYOMING STUDENT SUPPORT SERVICES PROJECT: 2020-2025

LOSS OF TDP-43 DISRUPTS THE PREFRONTAL NEURAL ACTIVITY AND CIRCUITRY: RELEVANCE FOR TDP-43 LINKED ADRD - THE OVERARCHING GOAL OF THIS PROPOSAL IS TO DETERMINE THE PATHOGENIC MECHANISM BY WHICH LOSS OF TAR DNA-BINDING PROTEIN 43 KDA (TDP-43) CONTRIBUTES TO THE EARLIEST NEURAL ACTIVITY AND NETWORK CHANGES THAT PRECEDE NEURON LOSS IN DISORDERS ASSOCIATED WITH TDP-43 PATHOLOGY. ALZHEIMER'S DISEASE (AD) AND ALZHEIMER'S DISEASE RELATED DEMENTIAS (ADRD) ARE THE MOST COMMON FORMS OF DEMENTIA CURRENTLY WITHOUT DISEASE MODIFYING THERAPY. ADRD SHARES MANY COGNITIVE AND PATHOLOGICAL FEATURES WITH AD AND CAN BE CLINICALLY DIFFICULT TO DISTINGUISH FROM AD. ONE OF THE MOST COMMON NON-CANONICAL PATHOLOGIC HALLMARKS OF AD IS TDP-43 PROTEINOPATHY, WHICH OCCURS IN ~30-57% OF AD BRAINS (AD-TDP). TDP-43 PROTEINOPATHY, FIRST SHOWN TO BE A MAJOR PATHOLOGICAL HALLMARK OF AMYOTROPHIC LATERAL SCLEROSIS (ALS) AND IN A MAJOR SUBTYPE OF FRONTOTEMPORAL LOBAR DEGENERATION (FTLD-TDP), IS ALSO FOUND IN OTHER NEURODEGENERATIVE DISEASES. SINCE COGNITIVE DECLINE AND BRAIN ATROPHY ARE EXACERBATED IN AD TDP RELATIVE TO AD, UNDERSTANDING THE PATHOGENIC ROLE OF TDP-43 IN AD-TDP AND FTLD-TDP THAT CONTRIBUTES TO THE EARLIEST NEURAL CIRCUIT ABNORMALITIES COULD FACILITATE IDENTIFICATION OF NOVEL THERAPEUTIC TARGETS AND TREATMENT STRATEGIES. BASED ON OUR PRELIMINARY STUDIES, WE HYPOTHESIZE THAT TDP-43 PLAYS ESSENTIAL ROLES IN MAINTAINING NORMAL NEURAL ACTIVITY AND CIRCUITRY THROUGH REGULATING RNA SPLICING OF SPECIFIC CALCIUM CHANNELS. TO TEST THIS HYPOTHESIS, WE WILL TAKE A MULTIDISCIPLINARY APPROACH CAPITALIZING ON OUR TEAM’S EXPERTISE IN TDP-43 BIOLOGY, MOUSE GENETIC AND NEUROPATHOLOGY, IN VIVO CALCIUM IMAGING AND CIRCUIT ANALYSIS IN MOUSE MODELS, AND TDP-43 DEPLETED CORTICAL NEURONS DERIVED FROM HPSC AND PATIENT-SPECIFIC IPSC MODELS. WE HAVE THE FOLLOWING THREE SPECIFIC AIMS. IN AIM #1, WE WILL PERFORM REPETITIVE IN VIVO CALCIUM IMAGING TO MONITOR CALCIUM ACTIVITY CHANGES FROM THE SAME PYRAMIDAL NEURONS IN AWAKE BEHAVING MICE, TO DETERMINE THE IMPACT OF PYRAMIDAL TDP-43 LOSS TO THE CORTICAL NETWORK. IN AIM #2, WE WILL PERFORM REPETITIVE IN VIVO CALCIUM IMAGING TO DETERMINE THE CONSEQUENCE OF TDP-43 DEPLETION SPECIFICALLY IN INHIBITORY INTERNEURONS OR SPARSELY IN BOTH EXCITATORY AND INHIBITORY NEURONS OF THE PFC. IN AIM #3, WE WILL USE MOUSE MODELS, HPSC DERIVED CORTICAL NEURONS, AND PATIENT BRAIN TISSUES OF AD-TDP AND FTLD-TDP TO DETERMINE THE MOLECULAR MECHANISMS WHEREBY TDP-43 LOSS LEADS TO EARLY ABERRANT NEURAL ACTIVITY IN THE PFC. WE BELIEVE THAT OUR WORK WILL NOT ONLY CLARIFY EARLY PATHOGENIC MECHANISMS OF TDP-43 LOSS BUT ALSO IDENTIFY NOVEL THERAPEUTIC TARGETS AND DESIGN OF EFFECTIVE THERAPEUTIC STRATEGY TO ATTENUATE THESE DEVASTATING DISORDERS OF THE ELDERLY

GERIATRIC EDUCATION CENTERS

RESIDENCY TRAINING IN PRIMARY CARE

UNIVERSITY CENTER FOR EXCELLENCE IN DEVELOPMENTAL DISABILITIES EDUCATION RESEARCH AND SERVICE

NEW AWARD TO THE UNIVERSITY OF WYOMING, AWARD NUMBER: DE-FE0032048, PROJECT ENTITLED: POWDER RIVER BASIN CORE-CM: ADVANCING STRATEGIES FOR CARBON ORE, RARE EARTH ELEMENT, AND CRITICAL MINERAL RESOURCE DEVELOPMENT IN THE NATION'S LARGEST COAL PRODUCING BASIN.

NEW AWARD TO THE UNIVERSITY OF WYOMING, AWARD NUMBER: DE-FE0032047. PROJECT ENTITLED: CORE-CM IN THE GREATER GREEN RIVER AND WIND RIVER BASINS: TRANSFORMING AND ADVANCING A NATIONAL COAL ASSET.

HEALTH CENTER PROGRAM

UNIVERSITY OF WYOMING - MANUFACTURING WORKS - WYOMING

GERIATRICS WORKFORCE ENHANCEMENT PROGRAM

STUDENT SUPPORT SERVICES PROGRAM

UPWARD BOUND PROGRAM

STUDENT SUPPORT SERVICES PROGRAM

NASA STRATEGIC GOAL 4: ENHANCE CAPABILITIES AND OPERATIONS TO CATALYZE CURRENT AND FUTURE MISSION SUCCESS. NASA INVESTMENTS IN STEM ENGAGEMENT ARE FOCUSED ON BUILDING A FUTURE STEM WORKFORCE THROUGH PROGRAM ELEMENTS DESIGNED TO BOLSTER CAPACITY AND TO ATTRACT ENGAGE AND ENABLE STUDENTS TO MOVE TOWARD STEM CAREERS THROUGH NASA-UNIQUE OPPORTUNITIES.

FEASIBILITY OF GEOPHYSICAL MONITORING OF CARBON SEQUESTRATED DEEP SALINE AQUIFERS

PROJECT ABSTRACT FOR SMITH LEVER 3(B) AND 3(C) CAPACITY GRANT UNIVERSITY OF WYOMING EXTENSION WYOMING IS THE LEAST POPULATED STATE IN THE NATION WITH 576,851 PEOPLE SPREAD OUT ACROSS 97,089 SQUARE MILES, 99.8 PERCENT OF WHICH IS RURAL. CHEYENNE, THE CAPITAL AND LARGEST CITY, HAS A POPULATION OF 65,132. THE STATE IS DIVIDED INTO 23 COUNTIES AND THE WIND RIVER INDIAN RESERVATION. FIFTY-THREE PERCENT OF LAND IN WYOMING IS OWNED BY THE FEDERAL OR STATE GOVERNMENT. MOST OF THE STATE'S ECONOMY IS CONCENTRATED IN THREE SECTORS: AGRICULTURE, MINERALS, AND TOURISM. THE STATE IS ALSO A MAJOR PRODUCER OF BEEF, SHEEP, WOOL, WIND ENERGY, COAL, AND NATURAL GAS. THE UNIVERSITY OF WYOMING IS THE ONLY UNIVERSITY IN THE STATE. THE UNIVERSITY OF WYOMING EXTENSION (UWE) WILL ENHANCE CAPACITY FOR SUCCESS AND THE RESILIENCY OF WYOMING PEOPLE, COMMUNITIES, ORGAN IZATIONS, AND BUSINESSES THROUGH EDUCATIONAL OPPORTUNITIES FUNDED IN PART THROUGH THE SMITH LEVER 3(B) AND 3(C) CAPACITY GRANT. A TEAM-BASED APPROACH TO EDUCATIONAL PROGRAM LEADERSHIP REVOLVES AROUND THREE FOCUS AREAS, WHICH ASSESS THE NEEDS OF WYOMING RESIDENTS AND COMMUNITIES AND THEN PRIORITIZE AND DEVELOP EDUCATIONAL PROGRAMS AROUND THOSE NEEDS. THE THREE FOCUS AREAS ARE: AGRICULTURAL AND NATURAL RESOURCES, COMMUNITY VITALITY AND HEALTH, AND 4-H YOUTH DEVELOPMENT. UWE WILL CONTINUE TO ENGAGE COMMUNITY MEMBERS AND ORGANIZATIONS AS PARTNERS AND COLLABORATORS IN EDUCATIONAL EFFORTS TO BUILD CAPACITY IN LOCAL COMMUNITIES THROUGHOUT WYOMING. CRITICAL ISSUE: COMMUNITIES, FAMILIES AND YOUTH (FOCUS ON INDIVIDUALS) DESCRIPTION: WYOMING NEEDS STRONG, DYNAMIC, SUSTAINABLE COMMUNITIES AND VOLUNTARY SECTORS. SUCH COMMUNITIES DEPEND UPON INDIVIDUALS WHO ARE WILLING TO ACCEPT LEADERSHIP ROLES IN MUNICIPALITY AND/OR COUNTY GOVERNMENT AND NONPROFIT ORGANIZATIONS TO TACKLE HUMAN AND COMMUNITY ISSUES, AND FAMILIES WHO ARE ABLE TO MAKE INFORMED DECISIONS AND MANAGE THEIR BASIC NEEDS TO THRIVE. FURTHERMORE, WYOMING, THE NATION, AND THE WORLD NEED YOUNG PEOPLE WHO HAVE THE SKILLS TO BE RESPONSIBLE CITIZENS AND CHANGE AGENTS FOR THE FUTURE. EDUCATIONAL PROGRAMS AROUND KEY COMMUNITY AND ECONOMIC DEVELOPMENT INTERESTS LIKE LEADERSHIP, MANAGEMENT AND POLICY CHALLENGES, WORKFORCE DEVELOPMENT, ENTREPRENEURSHIP, CIVIC ENGAGEMENT/VOLUNTEERISM, ECONOMIC VALUATION, AND INTEGRATED DECISION-MAKING INFLUENCE THE HEALTH OF A COMMUNITY AT ALL LEVELS. THE FINANCIAL VITALITY OF FAMILIES IS OFTEN TIED TO THE BOOM-AND-BUST CYCLE OF ENERGY SECTORS ACROSS WYOMING. PERSONAL FINANCIAL MANAGEMENT SKILLS ARE ESSENTIAL TO SURVIVING AND THRIVING THE ECONOMIC SWINGS ASSOCIATED WITH ENERGY PRODUCTION. WYOMING IS ALSO A RURAL AGRICULTURAL STATE AND EFFECTIVE GENERATIONAL TRANSITION OF MANAGEMENT IS CRUCIAL TO THE FUTURE OF WYOMING AGRICULTURE. EDUCATIONAL PROGRAMS CAN ENSURE THAT THE NEXT GENERATION HAS ACCESS TO THE TOOLS, KNOWLEDGE, AND RESOURCES NEEDED FOR VIABLE AND PROGRESSIVE WYOMING FARMS AND RANCHES. YOUTH DEVELOPMENT PROGRAMS CREATE WAYS TO ENGAGEYOUTH WITHIN THEIR COMMUNITIES, SCHOOLS, ORGANIZATIONS, PEER GROUPS, AND FAMILIES THROUGH OPPORTUNITIES THAT BUILD LEADERSHIP STRENGTHS AND DEVELOP RESILIENCY. IN 4-H, ADULT VOLUNTEERS PARTNER WITH UWE TO PROVIDE EDUCATIONAL PROGRAMS FOR YOUTH AND TRAINED VOLUNTEERS ARE ESSENTIAL IN SUPPORTING POSITIVE YOUTH DEVELOPMENT OUTCOMES. UWE EDUCATIONAL PROGRAMS TO SUPPORT COMMUNITIES, FAMILIES AND YOUTH: CIVIC HEALTH - COMMUNITY MEMBERS OFTEN DESIRE TO PURSUE A GOAL OR VISION YET STRUGGLE TO EFFECTIVELY WORK TOGETHER TO ACCOMPLISH THE OUTCOME, OR DO NOT HAVE THE SKILLS, KNOWLEDGE, OR SELF-AWARENESS TO MOVE FORWARD. COLLABORATION TO MOTIVATE ACTION, DEVELOP SKILLS AND FACILITATE THE PROCESSES THAT ADDRESS LOCAL AND REGIONAL NEEDS AND TO BUILD REGIONAL ECONOMIES WILL INCREASE THE CIVIC PARTICIPATION AND ENGAGEMENT IN AMERICAN LIFE. COMMUNITY ECONOMIC VITALITY - THE OVERALL GOAL OF UW EXTENSION ENTREPRENEURSHIP PROGRAMING IS TO IMPROVE THE VIBRANCY OF WYOMING'S E CONOMIC ENVIRONMENT. TO ACCOMPLISH THIS GOAL COMMUNITY-BASED EFFORTS WILL BE FACILITATED TO IMPROVE THE ECOSYSTEM FOR ENTREPRENEURIAL VENTURES TO DEVELOP, INCLUDING THE UNDERSTANDING OF WHAT COMMUNITY ECONOMIC DEVELOPMENT IS AND THE ROLE OF INDIVIDUALS, HOUSEHOLDS, BUSINESSES, COMMUNITIES, AND INSTITUTIONS HAVE IN BUILDING AND MAINTAINING A STRONG ECONOMY; DEVELOP AND SUPPORT PROGRAMMING IN YO UTH ENTREPRENEURSHIP; AND BUILD SKILLS IN VENTURE MANAGEMENT. INDIVIDUAL AND FAMILY RESOURCE MANAGEMENT - THE OVERALL GOAL OF FAMILY RESOURCE MANAGEMENT IS TO INCREASE WYOMING RESIDENTS' CAPACITY TO ADDRESS CONSUMER AND HOUSEHOLD ECONOMIC ISSUES BY OFFERING EDUCATIONAL PROGRAMS THAT FOCUS ON LIFELONG FINANCIAL MANAGEMENT AND DECISION-MAKING SKILLS. VOLUNTEER SUPPORT AND ENGAGEMENT - PROVIDE HIGH QUALITY LEARNING EXPERIENCES FOR 4-H VOLUNTEERS THAT SUPPORT THEIR INDIVIDUAL CAPACITY TO SERVE IN THE VARIOUS ROLES AVAILABLE TO THEM IN OUR EDUCATIONAL PROGRAMMING. TEEN PROGRAMMING AND ENGAGEMENT - INTENTIONALLY FRAME ALL 4-H LEARNING EXPERIENCES FROM A POSITIVE YOUTH DEVELOPMENT PERSPECTIVE TO SUPPORT PYD OUTCOMES. THIS INCLUDES INVOLVING TEENS IN PLANNING, IMPLEMENTING, AND EVALUATING 4-H LEARNING EXPERIENCES. THE CREATION OF "SEATS" FOR YOUTH ON 4-H COMMITTEES HISTORICALLY MADE UP ONLY OF ADULTS IS ONE ASPECT OF THIS GOAL. YOUTH WILL BE INCLUDED MORE IN MANY ASPECTS OF EDUCATIONAL EXPERIENCES PROVIDED BUT ALSO THROUGH MORE LIFE AND LEADERSHIP SKILL DEVELOPMENT OPPORTUNITIES FOR TEENS. CRITICAL ISSUE: COMMUNITY SOCIO-ECONOMIC PROSPERITY (FOCUS ON BUSINESSES) DESCRIPTION: WYOMING'S ECONOMY IS VULNERABLE BECAUSE OF ITS HISTORICAL ECONOMIC DEPENDENCE ON AGRICULTURE AND EXTRACTION INDUSTRIES, COUPLED WITH ITS SPARSE POPULATION. SOCIO-ECONOMIC PROSPERITY CAN BE ACHIEVED THROUGH EDUCATIONAL PROGRAMS TO STRENGTHEN INDIVIDUALS, FAMILIES, COMMUNITIES, AND RANCH/FARM OPERATIONS. IMPACT ANALYSIS OF NATURAL RESOURCE MANAGEMENT ON PUBLIC AND PRIVATE LANDS AND ALTERNATIVE LAND USES; CROP DIVERSIFICATION, INDUSTRY DEVELOPMENTWITH FEASIBLE PRODUCTION OPTIONS FOR WYOMING, NICHE MARKETING AND AGRICULTURAL TRADE IN THE NEW GLOBAL MARKET ENVIRONMENT; RANCH AND FARM MANAGEMENT STRATEGIES, INNOVATIVE PLANNING TOOLS FOR LIVESTOCK AND CROP ENTERPRISES, AND EVALUATION OF VARIOUS RISK MANAGEMENT STRATEGIES ARE EXAMPLES OF RESEARCH AND EDUCATIONAL PROGRAM PRIORITIES THAT WILL BRING ECONOMIC VALUE AND SUSTAINABILITY TO WYOMING. KNOWLEDGE OF DISASTER RESOURCES, DEVELOPMENT OF DISASTER PLANS, AND EFFECTIVE DECISION-MAKING STRATEGIES WILL ALSO PREPARE INDIVIDUALS, FAMILIES, AND COMMUNITIES TO MITIGATE POTENTIAL DISASTERS AND ENGAGE APPROPRIATE RESPONSES TO REDUCE THEIR VULNERABILITY TO DISASTERS. UWE EDUCATIONAL PROGRAMS TO SUPPORT COMMUNITY SOCIO-ECONOMIC PROSPERITY: LIVESTOCK HEALTH AND INFECTIOUS DISEASE - WYOMING LIVESTOCK PRODUCERS AND OWNERS MUST CONSTANTLY MANAGE HERD/FLOCK HEALTH AND DISEASE ISSUES. FAILURE TO PROPERLY MANAGE HEALTH AND DISEASE CONCERNS COULD BE DEVASTATING TO THE ECONOMIC VIABILITY AND WELL-BEING OF ALL WYOMING LIVESTOCK OPERATIONS. UWE WILL PROVIDE EDUCATIONAL PROGRAMS TO DECREASE LIVESTOCK DEATH AND ECONOMIC LOSSES AS WELL AS SUPPORT PRODUCERS TO RECEIVE "BEST PRACTICE" CERTIFICATIONS FOR THEIR OPERATION. AN EXAMPLE OF A BEST PRACTICE CERTIFICATION IS THE BEEF QUALITY ASSURANCE PROGRAM. MAINTAINING VIABLE AND PROGRESSIVE AG-OPERATIONS - EFFECTIVE GENERATIONAL TRANSITION OF MANAGEMENT IS CRUCIAL TO THE FUTURE OF WYOMI NG AGRICULTURE. NOT ONLY MUST WE ENSURE THAT THIS TRANSITION HAPPENS, BUT WE MUST ALSO ENSURE THAT THE NEXT GENERATION HAS ACCESS TO THE TOOLS, KNOWLEDGE, AND RESOURCES NEEDED FOR SUCCESS. UWE WILL WORK WITH PRODUCERS TO INCREASE DIVERSIFICATION OF THEIR ENTERPRISE(S); ENCOURAGE NEW MANAGEMENT PRACTICES THAT ENHANCE SUSTAINABILITY; AND PROVIDE EDUCATIONAL PROGRAMS AND TOOLS TO SUCCESSFULLY TRANSFER MANAGEMENT OF AG OPERATIONS TO A DIFFERENT GENERATION. CROP DIVERSITY - DIVERSIFICATION OF CROPS AND OUTPUTS WILL BRING ECONOMIC VALUE AND SUSTAINABILITY TO WYOMING FARMERS. LONGER, MORE DIVERSE CROP ROTATIONS INCREASE SOIL ORGANIC CARBON AND NITROGEN, AND SOIL MICROBIAL BIOMASS. HEALTHY SOILS CAN INCREASE INCOME THROUGH INCREASING YIELDS AND REDUCING PRODUCTION COSTS BY PROVIDING BETTER NUTRIENT AND WATER USE EFFICIENCIES, IMPROVING RESISTANCE TO DISEASE AND INSECT DAMAGE, AND BY REDUCING TILLAGE PASSES. TO INCREASE SOIL HEALTH, UWE WILL WORK WITH PRODUCERS TO IDENTIFY DIVERSE CROP ROTATIONS AND FACILITATE ADOPTION OF REDUCED-TILLAGE PRACTICES IN INTENSIVE IRRIGATED CROPPING SYSTEMS. ADDITIONALLY, CONSUMERS AND THE GENERAL PUBLIC ARE INTERESTED IN FARMING SYSTEMS THAT CONSERVE NATURAL RESOURCES AND BIODIVERSITY. COMMUNITY ECONOMIC VITALITY - THE OVERALL GOAL OF UW EXTENSION ENTREPRENEURSHIP PROGRAMING IS TO IMPROVE THE VIBRANCY OF WYOMING'S E CONOMIC ENVIRONMENT. TO ACCOMPLISH THIS GOAL COMMUNITY-BASED EFFORTS WILL BE FACILITATED TO IMPROVE THE ECOSYSTEM FOR ENTREPRENEURIAL VENTURES TO DEVELOP, INCLUDING THE UNDERSTANDING OF WHAT COMMUNITY ECONOMICDEVELOPMENT IS AND THE ROLE OF INDIVIDUALS, HOUSEHOLDS, BUSINESSES, COMMUNITIES, AND INSTITUTIONS HAVE IN BUILDING AND MAINTAINING A STRONG ECONOMY; DEVELOP AND SUPPORT PROGRAMMING IN YO UTH ENTREPRENEURSHIP; AND BUILD SKILLS IN VENTURE MANAGEMENT. CRITICAL ISSUE: HUMAN HEALTH, WELLNESS AND NUTRITION DESCRIPTION: THE U.S. CENTERS FOR DISEASE CONTROL AND PREVENTION ESTIMATES THAT "EACH YEAR 48 MILLION PEOPLE GET SICK, 128,000 ARE H OSPITALIZED, AND 3,000 DIE OF FOODBORNE DISEASES" IN THE UNITED STATES. RISK FACTORS RANGE FROM CONTAMINATED FOOD PRODUCTS TO FOODBORNE ILLNESSES RESULTING FROM IMPROPER FOOD HANDLING AND FOOD PRODUCTION PRACTICES. OVERWEIGHT AND OBESITY RATES CONTINUE TO INCREASE AND PLACE WYOMING RESIDENTS AT INCREASED RISK OF CHRONIC OBESITY-RELATED HEALTH ISSUES. ADDITIONALLY, ENVIRONMENTAL FACTORS SUCH AS EASY ACCESS TO UNHEALTHY FAST FOODS, LIMITED ACCESS TO RECREATIONAL FACILITIES OR PARKS, AND FEW SAFE OR EASY WAYS TO WALK IN A NEIGHBORHOOD INCREASE THE RISK OF BEINGOVERWEIGHT AND OBESE. EDUCATIONAL PROGRAMS FOCUSING ON FOOD SAFETY WILL STRIVE TO REDUCE THE INCIDENCES OF FOODBORNE ILLNESSES. USDA/FDA FOOD SAFETY RECOMMENDATIONS WILL BE DELIVERED THROUGH PROGRAMS FOR FOOD SERVICE EMPLOYEES AS WELL AS INDIVIDUALS AND FAMILIES PRESERVING AND PREPARING FOOD IN PRIVATE HOMES. MANY HEALTH, WELLNESS AND NUTRITION DECISIONS DEPEND NOT ONLY ON THE INDIVIDUAL BUT ALSO ON SOCIAL, CULTURAL, ECONOMIC, AND ENVIRONMENTAL FACTORS. EVIDENCE-BASED POLICY, SYSTEMS, AND ENVIRONMENT (PSE) STRATEGIES WILL BE USED TO INCREASE HEALTHY LIFESTYLE CHANGES AND DECREASE RISK OF OBESITY AND CHRONIC DISEASE. THE GOAL WILL BE TO INCREASE THE NUMBER OF PARTICIPANTS WHO MEET THE NATIONAL PHYSICAL ACTIVITY GUIDELINES AND THE NATIONAL DIETARY RECOMMENDATIONS. PARTICIPATION IN HORTICULTURE PROGRAMS WILL ALSO ENCOURAGE RESIDENTS TO BE MORE SELF-SUFFICIENT IN FOOD PRODUCTION AND LIVE A HEALTHIER LIFESTYLE. UWE PROGRAMMING AREAS TO SUPPORT HUMAN HEALTH, WELLNESS AND NUTRITION: HEATH PROMOTION AND EDUCATION - IMPROVED NUTRITION AND PHYSICAL ACTIVITY BEHAVIORS DECREASE RISK OF OBESITY AND CHRONIC DISEASE (E.G., DIABETES), WHICH ARE MAJOR ISSUES IN WYOMING. EDUCATIONAL PROGRAMS WILL BE OFFERED TO INCREASE PHYSICAL ACTIVITY AND STRENGTH TRAINING; INCREASE INTAKE OF FRUITS, VEGETABLES, AND WHOLE GRAINS; AND DECREASE FOODS TO LIMIT ADDED SALT, SUGAR, AND FAT. USDA/FDA FOOD SAFETY RECOMMENDATIONS WILL BE TAUGHT IN PROGRAMS FOR FOOD SERVICE EMPLOYEES AND FAMILIES PRESERVING AND PREPARING FOOD AT HOME. HEALTHY ENVIRONMENTS - GOING BEYOND EDUCATION IS NECESSARY TO IMPROVE HEALTHY BEHAVIORS AND DECREASE RATES OF CHRONIC DISEASE AND OBESITY. INDIVIDUALS MUST ALSO LIVE IN AN ENVIRONMENT THAT FACILITATES MAKING THE HEALTHY CHOICE THE EASY CHOICE. EVIDENCE-BASED POLICY, SYSTEMS, AND ENVIRONMENT (PSE) STRATEGIES CAN IMPROVE NUTRITION AND PHYSICAL ACTIVITY BEHAVIORS AND DECREASE RISK OF OBESITY AND CHRONIC DISEASE (E.G., DIABETES). EFFORTS WILL INCLUDE WORKING WITH COMMUNITY PARTNERS TO ADOPT RECOMMENDED PHYSICAL ACTIVITY AND NUTRITION PRACTICES AND GUIDELINES AND WILL BE MEASURED BY THE NUMBER OF ENVIRONMENTAL CHANGES MADE TO SUPPORT PHYSICAL ACTIVITY SUCH AS WALKING PATHS, STAIRWAY POSTERS, ETC. CONSUMER HORTICULTURE - CONSUMER HORTICULTURE IS ANYTHING RELATED TO PLANTS, GARDENS, OR LANDSCAPES THAT COULD BENEFIT INDIVIDUALS, COMMUNITIES, AND THE ENVIRONMENT. PARTICIPATION IN HORTICULTURAL PROGRAMS ALSO ENCOURAGES WYOMING RESIDENTS TO BE MORE SELF-SUFFICIENT AND LIVE A HEALTHIER LIFESTYLE BY INCREASING THEIR ACCESS TO FRESH PRODUCE. CRITICAL ISSUE: NATURAL SYSTEMS, FOOD AND FIBER PRODUCTION DESCRIPTION: INCREASING CLIMATE VARIABILITY, GLOBAL POPULATION GROWTH, AND ENVIRONMENTAL DEGRADATION HAS PLACED UNPRECEDENTED BURDENS ON OUR NATURAL SYSTEMS. WYOMING'S ECONOMY IS BASED HEAVILY ON NATURAL RESOURCE USE (MINERAL EXTRACTION, TOURISM <(>&<)> RECREATION, AGRICULTURAL PRODUCTION), WITH NEARLY HALF ITS LAND AREA PUBLICLY OWNED AND MANAGED BY GOVERNMENT AGENCIES. A MULTIDISCIPLINARY, SYSTEMS-BASED RESEARCH AND EDUCATIONAL APPROACH THAT CONTRIBUTES TO THOUGHTFUL MANAGEMENT OF WYOMING'S ABUNDANT NATURAL RESOURCES IS ESSENTIAL TO UNDERSTANDING THE INCREASING COMPLEXITY OF A RAPIDLY CHANGING WORLD. SCIENCE-BASED EDUCATIONAL PROGRAMS ARE CRITICAL TO IMPROVING PUBLIC POLICY, REDUCING CONFLICT, AND CONTRIBUTING TO ECONOMIC AND ECOLOGICAL SUSTAINABILITY. WYOMING'S PROGRAMS SEEK TO INCREASE KNOWLEDGE AND AWARENESS OF SUSTAINABLE RESOURCE USE INCLUDING PRODUCTIVE AND SUSTAINABLE AGRICULTURAL SYSTEMS, HEALTHY FORESTS AND RANGELANDS, WATER AND SOIL QUALITY, AND SUSTAINABLE LAND USE. WITH STAKEHOLDER INPUT, PROGRAMS WILL ADVANCE SUSTAINABLE AGRICULTURE AND LIVESTOCK PRODUCTION TO IMPROVE FOOD SECURITY, REDUCE HUNGER, INCREASE ECONOMIC RETURNS, AND SUPPORT THRIVING RURAL ECONOMIES. IN ADDITION, THESE PROGRAMS WILL ADDRESS THE NEEDS OF URBAN AND SMALL ACREAGE LANDOWNERS, PROVIDING EDUCATION IN SUSTAINABLE AND ENVIRONMENTALLY SOUND HORTICULTURAL PRACTICES. PURSUITOF TECHNOLOGICAL ADVANCES IN AGRICULTURAL PRODUCTION, PROCESSING, AND DI STRIBUTION WILL CONTRIBUTE TO SUSTAINABLE PRODUCTION OF FOOD, FIBER, AND BIOENERGY. THESE PROGRAMS WILL AID IN THE MAINTENANCE OF WYOMING'S NATURAL SYSTEMS WHILE CONTINUING TO CONTRIBUTE TO THE NEEDS OF A GROWING GLOBAL POPULATION. UWE PROGRAMMING AREAS TO SUPPORT NATURAL SYSTEMS, FOOD AND FIBER PRODUCTION: INVASIVE AND NOXIOUS WEEDS - INVASIVE WEEDS CAN CHANGE THE ECOLOGY OF A LANDSCAPE BY REPLACING NATIVE VEGETATION WHICH WILL HAVE ADVERSE EFFECTS ON SOIL HEALTH, WILDLIFE BOTH INVERTEBRATES AND VERTEBRATES, AND LIVESTOCK. LIVESTOCK PRODUCERS ALREADY RECOGNIZE THAT INVASIVE WEEDS CAUSE A REDUCTION IN FORAGE AND SEEK EDUCATIONAL PROGRAMS AND TRIALS TO CONTROL THE SPREAD OF INVASIVE WEEDS. LANDOWNERS AND LAND MANAGERS PARTICIPATING IN UWE PROGRAMS WILL SEE REDUCED AREAS INFESTED WITH INVASIVE AND NOXIOUS WEEDS. OTHERS THAT BENEFIT FROM BEING ABLE TO IDENTIFY AND UNDERSTAND THE SPREAD OF INVASIVE WEEDS ARE OUTDOOR RECREATIONISTS FROM HIKERS TO HUNTERS. CONTROLLING INVASIVE WEEDS MAINTAINS THE NATIVE VEGETATION WHICH IN TURN MAINTAINS THE ECOSYSTEM FOR THEM TO ENJOY OUTDOOR RECREATIONAL ENDEAVORS. COVER CROPS - COVER CROPS IMPROVE THE HEALTH AND FUNCTION OF SOIL. THESE BENEFITS LEAD TO BETTER NUTRIENT CYCLING, IMPROVED WATER INFILTRATION AND MORE CONSISTENT YIELDS OVER TIME. ADDITIONALLY, COVER CROPS SUPPRESS WEEDS, PREVENT EROSION, CONTROL DISEASES AND PESTS AS WELL AS HELP POLLINATORS. COVER CROPS ARE ALSO USED TO PROVIDE FORAGE FOR LIVESTOCK. EDUCATIONAL PROGRAMS ASSIST PRODUCERS IN GATHERING RESOURCES ON COVER CROP OPTIONS, HOW TO PLANT AND STRATEGIES FOR USE. INTEREST IN COVER CROPS HAS GROWN AS PRODUCERS HAVE SEEN INCREASED FORAGE SUPPLY, GROWING FORAGES IN PLACES THAT HAD BEEN UNPRODUCTIVE, AND IN WEED CONTROL EFFORTS. GENERAL PUBLIC RANGE EDUCATION - WHEN PUBLIC SPACE IS CONCERNED, THE DECISION MAKER CAN BE ANYONE. UNDERSTANDING HOW THE SHARED RESOURCE IS USED AND MANAGED CAN HELP NAVIGATE CONFLICT RESULTING FROM DIFFERENT EXPECTATIONS OF USER GROUPS. EXAMPLES OF UNDERSTANDING BASIC CAUSE AND EFFECT WITH THE ECOSYSTEM INCLUDE WHY IT'S IMPORTANT TO 'SHUT THE GATE', OR A RECREATIONAL FISHERMAN UNDERSTANDING THE SENSITIVITIES OF A RIPARIAN ZONE. ACCESS TO AND DEMAND ON RANGELANDS - MULTIPLE USER GROUPS REQUIRE AND/OR VALUE ACCESS TO UNMODIFIED RANGELANDS IN THE WESTERN US. MANY RANCHERS RELY ON THE OPPORTUNITY TO GRAZE LARGE ACREAGES OF PUBLIC LAND TO MAINTAIN THE VIABILITY OF THEIR BUSINESS. INCREASINGLY, RECREATIONISTS (TO INCLUDE HUNTERS, HIKERS, WILDLIFE VIEWERS, ETC.) ARE VALUING THE WIDE-OPEN SPACES THAT RANGELANDS PROVIDE. WHILE USE AND PUBLIC INTEREST IN RANGELANDS IS INCREASING, PUBLIC KNOWLEDGE ABOUT DIFFERENCES IN HOW DIFFERENT LANDS ARE MANAGED HAS NOT KEPT PACE.

WYOMING IS THE LEAST POPULATED STATE IN THE NATION WITH 576,851 PEOPLE SPREAD OUT ACROSS 97,089 SQUARE MILES, 99.8 PERCENT OF WHICH IS RURAL. THE STATE IS DIVIDED INTO 23 COUNTIES AND THE WIND RIVER INDIAN RESERVATION. FIFTY-THREE PERCENT OF LAND IN WYOMING IS OWNED BY THE FEDERAL OR STATE GOVERNMENT. MOST OF THE STATE'S ECONOMY IS CONCENTRATED IN THREE SECTORS: AGRICULTURE, MINERALS, AND TOURISM. THE UNIVERSITY OF WYOMING EXTENSION (UWE) WILL ENHANCE CAPACITY FOR SUCCESS AND THE RESILIENCY OF WYOMING PEOPLE, COMMUNITIES, ORGANIZATIONS, AND BUSINESSES THROUGH EDUCATIONAL OPPORTUNITIES. A TEAM-BASED APPROACH TO EDUCATIONAL PROGRAM LEADERSHIP IS TASKED WITH ASSESSING THE NEEDS OF WYOMING RESIDENTS AND COMMUNITIES, PRIORITIZING, AND DEVELOPING EDUCATIONAL PROGRAMS TO ADDRESS THOSE NEEDS. UWE WILL CONTINUE TO ENGAGE COMMUNITY MEMBERS AND ORGANIZATIONS AS PARTNERS AND COLLABORATORS IN EDUCATIONAL EFFORTS TO BUILD CAPACITY IN LOCAL COMMUNITIES THROUGHOUT WYOMING. CRITICAL ISSUE: COMMUNITIES, FAMILIES AND YOUTH. WYOMING NEEDS STRONG, DYNAMIC, SUSTAINABLE COMMUNITIES AND VOLUNTARY SECTORS TO THRIVE AND GROW. TO HELP FOSTER THE GROWTH AND DEVELOPMENT OF COMMUNITIES, FAMILIES, AND INDIVIDUALS, UW EXTENSION WILL FOCUS EDUCATIONAL EFFORTS ON THE FOLLOWING PROGRAM PRIORITIES: CIVIC HEALTH; INDIVIDUAL AND FAMILY RESOURCE MANAGEMENT; VOLUNTEER SUPPORT AND ENGAGEMENT; AND YOUTH DEVELOPMENT PROGRAMMING AND ENGAGEMENT. CRITICAL ISSUE: COMMUNITY SOCIO-ECONOMIC PROSPERITY. WYOMING'S ECONOMY IS VULNERABLE BECAUSE OF ITS HISTORICAL ECONOMIC DEPENDENCE ON AGRICULTURE AND EXTRACTION INDUSTRIES, COUPLED WITH ITS SPARSE POPULATION. SOCIO-ECONOMIC PROSPERITY CAN BE ACHIEVED THROUGH EDUCATIONAL PROGRAMS FOCUSED ON STRENGTHENING COMMUNITY ECONOMIC VITALITY, MAINTAINING VIABLE AND PROGRESSIVE AG OPERATIONS, FOSTER CROP DIVERSITY, PROMOTING LIVESTOCK HEALTH AND LIMITING INFECTIOUS DISEASE. CRITICAL ISSUE: HUMAN HEALTH, WELLNESS AND NUTRITION. MANY HEALTH, WELLNESS AND NUTRITION DECISIONS DEPEND NOT ONLY ON THE INDIVIDUAL BUT ALSO ON SOCIAL, CULTURAL, ECONOMIC, AND ENVIRONMENTAL FACTORS. EVIDENCE-BASED POLICY, SYSTEMS, AND ENVIRONMENT (PSE) STRATEGIES WILL BE USED TO INCREASE HEALTHY LIFESTYLE CHANGES AND DECREASE THE RISK OF OBESITY AND CHRONIC DISEASE. THE GOAL WILL BE TO INCREASE THE NUMBER OF PARTICIPANTS WHO MEET THE NATIONAL PHYSICAL ACTIVITY GUIDELINES AND THE NATIONAL DIETARY RECOMMENDATIONS. PARTICIPATION IN HORTICULTURE PROGRAMS WILL ALSO ENCOURAGE RESIDENTS TO BE MORE SELF-SUFFICIENT IN FOOD PRODUCTION AND LIVE A HEALTHIER LIFESTYLE. CRITICAL ISSUE: NATURAL SYSTEMS, FOOD AND FIBER PRODUCTION. INCREASING CLIMATE VARIABILITY, GLOBAL POPULATION GROWTH, AND ENVIRONMENTAL DEGRADATION HAVE PLACED UNPRECEDENTED BURDENS ON OUR NATURAL SYSTEMS. WYOMING'S ECONOMY IS BASED HEAVILY ON NATURAL RESOURCE USE (MINERAL EXTRACTION, TOURISM <(>&<)> RECREATION, AGRICULTURAL PRODUCTION), WITH NEARLY HALF ITS LAND AREA PUBLICLY OWNED AND MANAGED BY GOVERNMENT AGENCIES. A MULTIDISCIPLINARY, SYSTEMS-BASED EDUCATIONAL APPROACH THAT CONTRIBUTES TO THOUGHTFUL MANAGEMENT OF WYOMING'S ABUNDANT NATURAL RESOURCES IS ESSENTIAL TO UNDERSTANDING THE INCREASING COMPLEXITY OF A RAPIDLY CHANGING WORLD. UWE'S PROGRAMS SEEK TO INCREASE KNOWLEDGE AND AWARENESS OF SUSTAINABLE RESOURCE USE INCLUDING PRODUCTIVE AND SUSTAINABLE AGRICULTURAL SYSTEMS, HEALTHY FORESTS AND RANGELANDS, WATER AND SOIL QUALITY, AND SUSTAINABLE LAND USE. WITH STAKEHOLDER INPUT, PROGRAMS WILL ADVANCE SUSTAINABLE AGRICULTURE AND LIVESTOCK PRODUCTION TO IMPROVE FOOD SECURITY, REDUCE HUNGER, INCREASE ECONOMIC RETURNS, AND SUPPORT THRIVING RURAL ECONOMIES.

GRADUATE RESEARCH FELLOWSHIP PROGRAM (GRFP)

UNIVERSITY OF WYOMING EXTENSION. PROJECT ABSTRACT FOR SMITH LEVER 3(B) AND 3(C) CAPACITY GRANT. WYOMING IS THE LEAST POPULATED STATE IN THE NATION WITH 576,851 PEOPLE SPREAD OUT ACROSS 97,089 SQUARE MILES, 99.8 PERCENT OF WHICH IS RURAL. THE STATE IS DIVIDED INTO 23 COUNTIES AND THE WIND RIVER INDIAN RESERVATION. FIFTY-THREE PERCENT OF LAND IN WYOMING IS OWNED BY THE FEDERAL OR STATE GOVERNMENT. MOST OF THE STATE'S ECONOMY IS CONCENTRATED IN THREE SECTORS: AGRICULTURE, MINERALS, AND TOURISM. THE UNIVERSITY OF WYOMING EXTENSION (UWE) WILL ENHANCE CAPACITY FOR SUCCESS AND THE RESILIENCY OF WYOMING PEOPLE, COMMUNITIES, ORGANIZATIONS, AND BUSINESSES THROUGH EDUCATIONAL OPPORTUNITIES. A TEAM-BASED APPROACH TO EDUCATIONAL PROGRAM LEADERSHIP IS TASKED WITH ASSESSING THE NEEDS OF WYOMING RESIDENTS AND COMMUNITIES, PRIORITIZING, AND DEVELOPING EDUCATIONAL PROGRAMS TO ADDRESS THOSE NEEDS. UWE WILL CONTINUE TO ENGAGE COMMUNITY MEMBERS AND ORGANIZATIONS AS PARTNERS AND COLLABORATORS IN EDUCATIONAL EFFORTS TO BUILD CAPACITY IN LOCAL COMMUNITIES THROUGHOUT WYOMING. CRITICAL ISSUE: COMMUNITIES, FAMILIES AND YOUTH. WYOMING NEEDS STRONG, DYNAMIC, SUSTAINABLE COMMUNITIES AND VOLUNTARY SECTORS TO THRIVE AND GROW. TO HELP FOSTER THE GROWTH AND DEVELOPMENT OF COMMUNITIES, FAMILIES, AND INDIVIDUALS, UW EXTENSION WILL FOCUS EDUCATIONAL EFFORTS ON THE FOLLOWING PROGRAM PRIORITIES: CIVIC HEALTH; INDIVIDUAL AND FAMILY RESOURCE MANAGEMENT; VOLUNTEER SUPPORT AND ENGAGEMENT; AND YOUTH DEVELOPMENT PROGRAMMING AND ENGAGEMENT. CRITICAL ISSUE: COMMUNITY SOCIO-ECONOMIC PROSPERITY. WYOMING'S ECONOMY IS VULNERABLE BECAUSE OF ITS HISTORICAL ECONOMIC DEPENDENCE ON AGRICULTURE AND EXTRACTION INDUSTRIES, COUPLED WITH ITS SPARSE POPULATION. SOCIO-ECONOMIC PROSPERITY CAN BE ACHIEVED THROUGH EDUCATIONAL PROGRAMS FOCUSED ON STRENGTHENING COMMUNITY ECONOMIC VITALITY, MAINTAINING VIABLE AND PROGRESSIVE AG OPERATIONS, FOSTER CROP DIVERSITY, PROMOTING LIVESTOCK HEALTH AND LIMITING INFECTIOUS DISEASE. CRITICAL ISSUE: HUMAN HEALTH, WELLNESS AND NUTRITION. MANY HEALTH, WELLNESS AND NUTRITION DECISIONS DEPEND NOT ONLY ON THE INDIVIDUAL BUT ALSO ON SOCIAL, CULTURAL, ECONOMIC, AND ENVIRONMENTAL FACTORS. EVIDENCE-BASED POLICY, SYSTEMS, AND ENVIRONMENT (PSE) STRATEGIES WILL BE USED TO INCREASE HEALTHY LIFESTYLE CHANGES AND DECREASE THE RISK OF OBESITY AND CHRONIC DISEASE. THE GOAL WILL BE TO INCREASE THE NUMBER OF PARTICIPANTS WHO MEET THE NATIONAL PHYSICAL ACTIVITY GUIDELINES AND THE NATIONAL DIETARY RECOMMENDATIONS. PARTICIPATION IN HORTICULTURE PROGRAMS WILL ALSO ENCOURAGE RESIDENTS TO BE MORE SELF-SUFFICIENT IN FOOD PRODUCTION AND LIVE A HEALTHIER LIFESTYLE. CRITICAL ISSUE: NATURAL SYSTEMS, FOOD AND FIBER PRODUCTION. INCREASING CLIMATE VARIABILITY, GLOBAL POPULATION GROWTH, AND ENVIRONMENTAL DEGRADATION HAVE PLACED UNPRECEDENTED BURDENS ON OUR NATURAL SYSTEMS. WYOMING'S ECONOMY IS BASED HEAVILY ON NATURAL RESOURCE USE (MINERAL EXTRACTION, TOURISM <(>&<)> RECREATION, AGRICULTURAL PRODUCTION), WITH NEARLY HALF ITS LAND AREA PUBLICLY OWNED AND MANAGED BY GOVERNMENT AGENCIES. A MULTIDISCIPLINARY, SYSTEMS-BASED EDUCATIONAL APPROACH THAT CONTRIBUTES TO THOUGHTFUL MANAGEMENT OF WYOMING'S ABUNDANT NATURAL RESOURCES IS ESSENTIAL TO UNDERSTANDING THE INCREASING COMPLEXITY OF A RAPIDLY CHANGING WORLD. UWE'S PROGRAMS SEEK TO INCREASE KNOWLEDGE AND AWARENESS OF SUSTAINABLE RESOURCE USE INCLUDING PRODUCTIVE AND SUSTAINABLE AGRICULTURAL SYSTEMS, HEALTHY FORESTS AND RANGELANDS, WATER AND SOIL QUALITY, AND SUSTAINABLE LAND USE. WITH STAKEHOLDER INPUT, PROGRAMS WILL ADVANCE SUSTAINABLE AGRICULTURE AND LIVESTOCK PRODUCTION TO IMPROVE FOOD SECURITY, REDUCE HUNGER, INCREASE ECONOMIC RETURNS, AND SUPPORT THRIVING RURAL ECONOMIES.

WYOMING IS THE LEAST POPULATED STATE IN THE NATION WITH 576,851 PEOPLE SPREAD OUT ACROSS 97,089 SQUARE MILES, 99.8 PERCENT OF WHICH IS RURAL. THE STATE IS DIVIDED INTO 23 COUNTIES AND THE WIND RIVER INDIAN RESERVATION. FIFTY-THREE PERCENT OF LAND IN WYOMING IS OWNED BY THE FEDERAL OR STATE GOVERNMENT. MOST OF THE STATE'S ECONOMY IS CONCENTRATED IN THREE SECTORS: AGRICULTURE, MINERALS, AND TOURISM. THE UNIVERSITY OF WYOMING EXTENSION (UWE) WILL ENHANCE CAPACITY FOR SUCCESS AND THE RESILIENCE OF WYOMING PEOPLE, COMMUNITIES, ORGANIZATIONS, AND BUSINESSES THROUGH EDUCATIONAL OPPORTUNITIES. A TEAM-BASED APPROACH TO EDUCATIONAL PROGRAM LEADERSHIP IS TASKED WITH ASSESSING THE NEEDS OF WYOMING RESIDENTS AND COMMUNITIES, PRIORITIZING, AND DEVELOPING EDUCATIONAL PROGRAMS TO ADDRESS THOSE NEEDS. UWE WILL CONTINUE TO ENGAGE COMMUNITY MEMBERS AND ORGANIZATIONS AS PARTNERS AND COLLABORATORS IN EDUCATIONAL EFFORTS TO BUILD CAPACITY IN LOCAL COMMUNITIES THROUGHOUT WYOMING. CRITICAL ISSUE: COMMUNITIES, FAMILIES AND YOUTH. WYOMING NEEDS STRONG, DYNAMIC, SUSTAINABLE COMMUNITIES AND VOLUNTARY SECTORS TO THRIVE AND GROW. TO HELP FOSTER THE GROWTH AND DEVELOPMENT OF COMMUNITIES, FAMILIES, AND INDIVIDUALS, UW EXTENSION WILL FOCUS EDUCATIONAL EFFORTS ON THE FOLLOWING PROGRAM PRIORITIES: CIVIC HEALTH; INDIVIDUAL AND FAMILY RESOURCE MANAGEMENT; VOLUNTEER SUPPORT AND ENGAGEMENT; AND YOUTH DEVELOPMENT PROGRAMMING AND ENGAGEMENT. CRITICAL ISSUE: COMMUNITY SOCIO-ECONOMIC PROSPERITY. WYOMING'S ECONOMY IS VULNERABLE BECAUSE OF ITS HISTORICAL ECONOMIC DEPENDENCE ON AGRICULTURE AND EXTRACTION INDUSTRIES, COUPLED WITH ITS SPARSE POPULATION. SUCCESS AND PROSPERITY CAN BE ACHIEVED THROUGH EDUCATIONAL PROGRAMS FOCUSED ON STRENGTHENING COMMUNITY ECONOMIC VITALITY, MAINTAINING VIABLE AND PROGRESSIVE AG OPERATIONS, FOSTERING CROP DIVERSITY, PROMOTING LIVESTOCK HEALTH AND LIMITING INFECTIOUS DISEASE. CRITICAL ISSUE: HUMAN HEALTH, WELLNESS AND NUTRITION. MANY HEALTH, WELLNESS AND NUTRITION DECISIONS DEPEND NOT ONLY ON THE INDIVIDUAL BUT ALSO ON SOCIAL, CULTURAL, ECONOMIC, AND ENVIRONMENTAL FACTORS. EVIDENCE-BASED POLICY, SYSTEMS, AND ENVIRONMENT (PSE) STRATEGIES WILL BE USED TO INCREASE HEALTHY LIFESTYLE CHANGES AND DECREASE THE RISK OF OBESITY AND CHRONIC DISEASE. THE GOAL WILL BE TO INCREASE THE NUMBER OF PARTICIPANTS WHO MEET THE NATIONAL PHYSICAL ACTIVITY GUIDELINES AND THE NATIONAL DIETARY RECOMMENDATIONS. PARTICIPATION IN HORTICULTURE PROGRAMS WILL ALSO ENCOURAGE RESIDENTS TO BE MORE SELF-SUFFICIENT IN FOOD PRODUCTION AND LIVE A HEALTHIER LIFESTYLE. CRITICAL ISSUE: NATURAL SYSTEMS, FOOD AND FIBER PRODUCTION. GROWING SEASON VARIABILITY, GLOBAL POPULATION GROWTH, AND ENVIRONMENTAL FACTORS HAVE PLACED UNPRECEDENTED BURDENS ON OUR NATURAL SYSTEMS. WYOMING'S ECONOMY IS BASED HEAVILY ON NATURAL RESOURCE USE (MINERAL EXTRACTION, TOURISM <(>&<)> RECREATION, AGRICULTURAL PRODUCTION), WITH NEARLY HALF ITS LAND AREA PUBLICLY OWNED AND MANAGED BY GOVERNMENT AGENCIES. A MULTIDISCIPLINARY, SYSTEMS-BASED EDUCATIONAL APPROACH THAT CONTRIBUTES TO THOUGHTFUL MANAGEMENT OF WYOMING'S ABUNDANT NATURAL RESOURCES IS ESSENTIAL TO UNDERSTANDING THE INCREASING COMPLEXITY OF A RAPIDLY CHANGING WORLD. UWE'S PROGRAMS SEEK TO INCREASE KNOWLEDGE AND AWARENESS OF EFFECTIVE RESOURCE USE INCLUDING PRODUCTIVE AND VIABLE AGRICULTURAL SYSTEMS, HEALTHY FORESTS AND RANGELANDS, WATER AND SOIL QUALITY, AND PRODUCTIVE LAND USE. WITH STAKEHOLDER INPUT, PROGRAMS WILL ADVANCE LONG TERM SUCCESS IN AGRICULTURE AND LIVESTOCK PRODUCTION TO IMPROVE FOOD SECURITY, REDUCE HUNGER, INCREASE ECONOMIC RETURNS, AND SUPPORT THRIVING RURAL ECONOMIES.

NATIONAL CENTER FOR EDUCATION RESEARCH

UNIVERSITY OF WYOMING EXTENSION SMITH-LEVER 3(B) <(>&<)> 3(C)

DMREF: GOALI: SALT SEPARATION MEMBRANES BASED ON MODIFIABLE TWO-DIMENSIONAL COVALENT ORGANIC FRAMEWORKS

SELF-NONSELF RECOGNITION AND MULTICELLULARITY IN MYXOBACTERIA - ABSTRACT A FUNDAMENTAL QUESTION IN BIOLOGY IS HOW INDIVIDUAL CELLS WITHIN A MULTICELLULAR ORGANISM RECOGNIZE OTHER CELLS AS SELF TO COOPERATIVELY FUNCTION IN TISSUES, ORGANS AND AS WHOLE INDIVIDUALS. TO ADDRESS THIS COMPLEX QUESTION, WE STUDY A RELATIVELY SIMPLE AND EXPERIMENTALLY TRACKABLE MODEL ORGANISM, MYXOCOCCUS XANTHUS. ALTHOUGH A BACTERIUM, M. XANTHUS EXHIBITS MANY TRAITS FOUND IN TISSUES AND MORE COMPLEX MULTICELLULAR SPECIES. ONE TRAIT IS MULTICELLULAR DEVELOPMENT IN RESPONSE TO STARVATION. ANOTHER TRAIT, WE DISCOVERED, IS THE ABILITY OF CELLS TO DISTINGUISH BETWEEN SELF AND NONSELF FOR THE EXCHANGE OF CELLULAR PROTEINS AND LIPIDS. RECOGNITION IS MEDIATED BY A POLYMORPHIC CELL SURFACE RECEPTOR CALLED TRAA AND ITS PARTNER TRAB. ONLY CELLS THAT BEAR IDENTICAL OR NEARLY IDENTICAL TRAA RECEPTORS ENGAGE BY HOMOTYPIC INTERACTIONS. SOCIAL OUTCOMES FROM THIS PROCESS, CALLED OUTER MEMBRANE EXCHANGE (OME), VARY DEPENDING ON THE PROPERTIES OF THE INTERACTING CELLS. IN SOME CASES, OME LEADS TO COOPERATIVE INTERACTIONS WHEREBY HEALTHY DONORS REPAIR DAMAGED CELLS BY REPLENISHING THEIR CELL COMPONENTS. IN OTHER CASES, OME LEADS TO ANTAGONISM WHEN PARTNERING CELLS ARE NOT CLONAL. DISCRIMINATION OCCURS BY POLYMORPHIC TOXIN TRANSFER TO RECIPIENT CELLS THAT LACK COGNATE IMMUNITY. OUR FUTURE GOALS ARE MULTIFACETED WITH RESPECT TO UNDERSTANDING OME AND, MORE BROADLY, HOW CELLS RECOGNIZE SELF AND TRANSITION TOWARD MULTICELLULARITY. OVER THE NEXT FIVE YEARS WE WILL CRITICALLY EXAMINE HOW OME LEADS TO COOPERATIVITY. ONE AREA OF INVESTIGATION IS HOW TRAA/B DIRECTS EMERGENT BEHAVIORS IN POPULATIONS THAT INCLUDE SYNCHRONIZED AND COORDINATED MOVEMENTS. THIS WILL BE EXPLORED BY MONITORING GLOBAL GENE EXPRESSION AND HOW TRAA/B INTERACTS WITH A SIGNAL TRANSDUCTION PATHWAY THAT CONTROLS MOTILITY. CELL SYNCHRONIZATION IS BEING STUDIED WITH A BIOSENSOR THE MONITORS’ CALCIUM FLUXES IN CELLS. OTHER APPROACHES WILL PROBE HOW M. XANTHUS RESPONDS AND ADAPTS TO ENVIRONMENTAL STRESSES, WHEREBY THOSE ADAPTATIONS ARE TRANSFERRED TO NAÏVE POPULATIONS BY OME. A SECOND AREA OF RESEARCH ADDRESSES HOW MYXOBACTERIA RAPIDLY DIVERGE INTO DIFFERENT SOCIAL GROUPS IN NATURAL ENVIRONMENTS. OUR PRELIMINARY FINDINGS INDICATE THAT HORIZONTAL GENE TRANSFER BY NON-LYTIC TRANSDUCING PARTICLES MEDIATE POPULATION DIVERGENCE BY CARRYING POLYMORPHIC GENES INVOLVED IN SOCIAL DISCRIMINATION. A THIRD FOCUS AREA WILL ELUCIDATE THE MECHANISM OF OME THOUGHT TO INVOLVE OUTER MEMBRANE FUSION. FINALLY, WE WILL EXPLORE NEW MECHANISMS OF SELF- RECOGNITION AND ITS ROLE IN MULTICELLULAR LIFE.

UNIVERSITY OF WYOMING EXTENSION SMITH-LEVER 3(B) & 3 (C)

UNIVERSITY OF WYOMING EXTENSION SMITH-LEVER 3(B) & 3(C)

UNIVERSITY OF WYOMING EXTENSION SMITH-LEVER 3(B) & 3(C)

UNIVERSITY OF WYOMING UPWARD BOUND MATH/SCIENCE - 2017

UNIVERSITY OF WYOMING - MANUFACTURING WORKS - WYOMING

NEW; STUDIES OF PHOTOINDUCED ELECTRON TRANSFER FROM DYES, POLYMERS AND QUANTUM CONFINED SYSTEMS INTO SEMICONDUCTING SINGLE CRYSTALS; PI: BRUCE A. PAR

UNIVERSITY OF WYOMING SMITH LEVER 3B AND 3C

CARBON SEQUESTRATION MONITORING ACTIVITIES

UNIVERSITY OF WYOMING SMITH LEVER 3B & 3C

COLLABORATIVE RESEARCH: NETWORK CLUSTER: BEDROCK CONTROLS ON THE DEEP CRITICAL ZONE, LANDSCAPES, AND ECOSYSTEMS

SMITH LEVER 3(B) AND (C)

UNIVERSITY OF WYOMING MCNAIR SCHOLARS PROGRAM GRANT PROPOSAL - 2017

MECHANISMS UNDERLYING CONTINUOUS SPIKE-WAVES DURING SLOW-WAVE SLEEP IN A MOUSE MODEL OF FOCAL CORTICAL DYSPLASIA

SMITH LEVER 3BC

ELUCIDATING THE CELLULAR MECHANISMS OF PRION PROPAGATION AND CLEARANCE FOR DEVISI

PREVENTION TECHNOLOGY TRANSFER CENTERS FOR REGION 8 - THE WYOMING SURVEY & ANALYSIS CENTER (WYSAC) IS UNIQUELY QUALIFIED TO PROVIDE TRAINING AND TECHNICAL ASSISTANCE (T/TA) TO THE SUBSTANCE MISUSE PREVENTION COMMUNITY IN THE DEPARTMENT OF HEALTH AND HUMAN SERVICE (HHS) REGION 8 THROUGH THE ESTABLISHMENT OF A MOUNTAIN PLAINS PREVENTION TECHNOLOGY TRANSFER CENTER (REGION 8 PTTC) AT THE UNIVERSITY OF WYOMING, IN PARTNERSHIP WITH THE EDUCATIONAL DEVELOPMENT CENTER, INC. (EDC). THE TARGET POPULATION FOR THE PTTC AT THE UNIVERSITY OF WYOMING WILL INCLUDE KEY STATE AND LOCAL PREVENTION PROFESSIONALS, COALITION MEMBERS, PRE-PROFESSIONALS DESIRING TO ENTER THE FIELD, TRIBAL MEMBERS, AND OTHER INTERESTED PARTIES. WITH A TOTAL OF SIX RELATED STATE AGENCIES, 281 COUNTIES, AND 29 TRIBES, MANY WITH PREVENTION COALITIONS AND STAFF, WE ESTIMATE SERVING AT LEAST AS 2,000 UNIQUE INDIVIDUALS EACH YEAR, WITH A TARGET OF 15,000 OVER THE LIFETIME OF THE COLLABORATIVE AGREEMENT. GOALS FOR THE PTTC AT THE UNIVERSITY OF WYOMING INCLUDE THE DELIVERY OF HIGH-QUALITY T/TA TO THE SUBSTANCE MISUSE PREVENTION WORKFORCE IN REGION 8 AND ACROSS THE COUNTRY, SUPPORTING AND BUILDING THE SUBSTANCE MISUSE PREVENTION WORKFORCE IN REGION 8 AND ACROSS THE COUNTRY THROUGH COLLABORATION AND COMMUNICATION WITH STATE AGENCIES, TRIBAL NATIONS, AND THE PTTC NETWORK, AND ADVANCING THE SUBSTANCE MISUSE PREVENTION FIELD THROUGH SUBJECT MATTER EXPERTISE IN DATA COLLECTION, NEEDS ASSESSMENT, PROCESS AND OUTCOME EVALUATION, DATA VISUALIZATION, AND THE DEVELOPMENT OF A PREVENTION FELLOWSHIP PROGRAM. WYSAC FILLS A GAP IN THE CURRENT PTTC SYSTEM WITH SPECIAL EXPERTISE IN DATA COLLECTION, NEEDS ASSESSMENT, PROCESS AND OUTCOME EVALUATION, DATA VISUALIZATION, AND THE USE OF APPLIED PREVENTION RESEARCH TO IMPROVE THE QUALITY OF INTERVENTIONS, TRAININGS, AND OTHER PREVENTION SERVICES.

NOCICEPTOR MATURATION AND RESPONSE TO PERIPHERAL INJURY

THE OFFICE OF STEM ENGAGEMENT (OSTEM) SEEKS TO: ATTRACT STUDENTS TO STEM THROUGH UNIQUE LEARNING OPPORTUNITIES THAT SPARK INTEREST AND PROVIDE CONNECTIONS TO NASAS MISSION AND WORK ENGAGE STUDENTS IN AUTHENTIC LEARNING EXPERIENCES WITH NASAS PEOPLE

COLLEGE ACCESS CHALLENGE GRANT PROGRAM

CORTISOL REGULATION OF PERINATAL ADIPOSE TISSUE AND SHEEP NEONATAL LEPTIN PEAK

TRIO - STUDENT SUPPORT SERVICES - STUDENT SUPPORT SERVICES PROGRAM

WYOMING INTERNS TO TEACHER SCHOLARS (WITS) PROGRAM

NURSE EDUCATION, PRACTICE, QUALITY, AND RETENTION - INTERPROFESSIONAL COLLBORATIVE PRACTICE

UPWARD BOUND MATH & SCIENCE

UPWARD BOUND MATH SCIENCE (UBMS) AT THE UNIVERSITY OF WYOMING

COALBED NATURAL GAS PRODUCED WATER ISSUES

RONALD E. MCNAIR POST-BACCALAUREATE ACHIEVEMENT

THE MCNAIR SCHOLARS PROGRAM FUNDS SERVICES AND ACTIVITIES RELATED TO DISADVANTAGED STUDENTS' SUCCESSFUL ENROLLMENT INTO GRADUATE SCHOOL AND ATTAINMENT OF A DOCTORAL DEGREE.

SMITH LEVER 3(B)AND (C)

UNIVERSITY OF WYOMING EDUCATIONAL OPPORTUNITY CENTERS - 2 (EOC-2)

THE UNIVERSITY OF WYOMING'S AGRICULTURAL EXPERIMENT STATION (WAES) IS HOUSED WITHIN THE COLLEGE OF AGRICULTURE, LIFE SCIENCES AND NATURAL RESOURCES. THE VISION OF THE COLLEGE IS TO SUPPORT THRIVING AGRICULTURE, NATURAL RESOURCES, PEOPLE, AND COMMUNITIES THROUGH INTEGRATING QUALITY EDUCATION, INNOVATIVE RESEARCH, AND IMPACTFUL ENGAGEMENT. WAES IS CONCERNED WITH FINDING SOLUTIONS TO CONTEMPORARY ISSUES AFFECTING WYOMING AND THE REGION THROUGH HIGH-QUALITY RESEARCH, CREATIVE SCHOLARSHIP, RESPONSIVE SERVICE, AND STATEWIDE ENGAGEMENT, EMPOWERING THE PEOPLE OF WYOMING TO MAKE CHOICES THAT ENHANCE THEIR QUALITY OF LIFE. THE PURPOSE OF HATCH CAPACITY FUNDING IS TO CONDUCT AGRICULTURAL RESEARCH PROGRAMS AT STATE AGRICULTURAL EXPERIMENT STATIONS IN THE 50 STATES, THE DISTRICT OF COLUMBIA, AND THE INSULAR AREAS. HATCH ACTIVITIES ARE BROAD AND INCLUDE RESEARCH ON ALL ASPECTS OF AGRICULTURE, INCLUDING SOIL AND WATER CONSERVATION AND USE; PLANT AND ANIMAL PRODUCTION, PROTECTION, AND HEALTH; PROCESSING, DISTRIBUTION, SAFETY, MARKETING, AND UTILIZATION OF FOOD AND AGRICULTURAL PRODUCTS; FORESTRY, INCLUDING RANGE MANAGEMENT AND RANGE PRODUCTS; MULTIPLE USE OF FOREST RANGELANDS, AND URBAN FORESTRY; AQUACULTURE; HOME ECONOMICS; HUMAN NUTRITION; RURAL AND COMMUNITY DEVELOPMENT AS IT RELATES TO AGRICULTURE; SUSTAINABLE AGRICULTURE; AND MOLECULAR BIOLOGY AND BIOTECHNOLOGY INASMUCH AS WORK CAN CONTRIBUTE TO AGRICULTURAL ADVANCEMENTS. WAES USES HATCH FUNDING TO SUPPORT FUNDAMENTAL AND APPLIED RESEARCH ON AGRICULTURAL, NATURAL, AND COMMUNITY RESOURCE ISSUES RELATED TO THE CURRENT AND FUTURE NEEDS OF WYOMING, THE REGION, THE NATION, AND THE WORLD. WAES MAINTAINS FOUR RESEARCH AND EXTENSION (R<(>&<)>E) CENTERS AROUND THE STATE THAT CONDUCT RESEARCH PROJECTS FOCUSED ON PRIORITIES AND SERVICES OF INTEREST TO FARMERS, RANCHERS, CONSUMERS, AND COMMUNITIES, AND THAT HAVE STRONG EDUCATIONAL AND COMMUNITY ENGAGEMENT COMPONENTS. WAES SEEKS TO INCREASE RESEARCH ENGAGEMENT BY COLLABORATING WITH DIVERSE RESEARCH PARTNERS WITH MUTUAL INTERESTS; INCREASING RESEARCH INTEGRATED WITH OTHER COLLEGE MISSION AREAS; AND ENHANCING RESEARCH RELEVANCE BY CONTINUING TO UPDATE AND EXPAND WYOMING PRODUCTION AGRICULTURE RESEARCH PRIORITIES. COLLEGE RESEARCH FACULTY IN NINE DEPARTMENTS-AGRICULTURAL <(>&<)> APPLIED ECONOMICS, ANIMAL SCIENCE, BOTANY, ECOSYSTEM SCIENCE <(>&<)> MANAGEMENT, FAMILY AND CONSUMER SCIENCES, MOLECULAR BIOLOGY, PLANT SCIENCES, VETERINARY SCIENCES, AND ZOOLOGY <(>&<)> PHYSIOLOGY-CONDUCT HATCH-FUNDED PROJECTS ADDRESSING AT LEAST ONE OF FOUR CRITICAL ISSUES: O COMMUNITIES, FAMILIES <(>&<)> YOUTH O COMMUNITY SOCIO-ECONOMIC PROSPERITY O HUMAN HEALTH, WELLNESS <(>&<)> NUTRITION O NATURAL SYSTEMS, FOOD <(>&<)> FIBER PRODUCTION HATCH PROJECT PROPOSALS ARE SUBMITTED TO THE NATIONAL INSTITUTE OF FOOD AND AGRICULTURE (NIFA) FOR FINAL APPROVAL AFTER A RIGOROUS PEER REVIEW PROCESS, AND APPROVAL BY THE ASSOCIATE DEAN AND DIRECTOR OF THE WYOMING AGRICULTURAL EXPERIMENT STATION. NIFA-APPROVEDCAPACITY PROJECTS ARE UPLOADED INTO THE NIFA REPORTING SYSTEM (NRS) WHERE PROJECT RESULTS ARE REPORTED ON AN ANNUAL BASIS AND NIFA AGAIN REVIEWS AND APPROVES THESE SUBMISSIONS. THIS MULTISTEP PEER-REVIEW, EVALUATION, RESULTS REPORTING, AND APPROVAL PROCESS ENSURES THAT PROJECTS ARE RELEVANT, METHODOLOGICALLY SOUND, AND MEET THE CRITERIA REQUIRED FOR FUNDING UNDER HATCH GUIDELINES.

HATCH REGULAR CAPACITY

COLLEGE ACCESS CHALLENGE GRANT PROGRAM

HEALTH AND HUMAN SAFETY RESEARCH ON WHETHER WILDLIFE COULD BE EXPOSED TO SARS-COV-2 FROM WASTEWATER TREATMENT PLANTS

THE PURPOSE OF HATCH CAPACITY FUNDING IS TO CONDUCT AGRICULTURAL RESEARCH PROGRAMS AT STATE AGRICULTURAL EXPERIMENT STATIONS IN THE 50 STATES, THE DISTRICT OF COLUMBIA, AND THE INSULAR AREAS. HATCH ACTIVITIES ARE BROAD AND INCLUDE RESEARCH ON ALL ASPECTS OF AGRICULTURE, INCLUDING SOIL AND WATER CONSERVATION AND USE; PLANT AND ANIMAL PRODUCTION, PROTECTION, AND HEALTH; PROCESSING, DISTRIBUTION, SAFETY, MARKETING, AND UTILIZATION OF FOOD AND AGRICULTURAL PRODUCTS; FORESTRY, INCLUDING RANGE MANAGEMENT AND RANGE PRODUCTS; MULTIPLE USE OF FOREST RANGELANDS, AND URBAN FORESTRY; AQUACULTURE; HOME ECONOMICS; HUMAN NUTRITION; RURAL AND COMMUNITY DEVELOPMENT AS IT RELATES TO AGRICULTURE; SUSTAINABLE AGRICULTURE; AND MOLECULAR BIOLOGY AND BIOTECHNOLOGY INASMUCH AS WORK CAN CONTRIBUTE TO AGRICULTURAL ADVANCEMENTS. WAES IS CONCERNED WITH FINDING SOLUTIONS TO CONTEMPORARY ISSUES AFFECTING WYOMING AND THE REGION THROUGH HIGH-QUALITY RESEARCH, CREATIVE SCHOLARSHIP, RESPONSIVE SERVICE, AND STATEWIDE ENGAGEMENT, EMPOWERING THE PEOPLE OF WYOMING TO MAKE CHOICES THAT ENHANCE THEIR QUALITY OF LIFE. WAES USES HATCH FUNDING TO SUPPORT FUNDAMENTAL AND APPLIED RESEARCH ON AGRICULTURAL, NATURAL, AND COMMUNITY RESOURCE ISSUES RELATED TO THE CURRENT AND FUTURE NEEDS OF WYOMING, THE REGION, THE NATION, AND THE WORLD. WAES MAINTAINS FOUR RESEARCH AND EXTENSION (R<(>&<)>E) CENTERS AROUND THE STATE THAT CONDUCT RESEARCH PROJECTS FOCUSED ON PRIORITIES AND SERVICES OF INTEREST TO FARMERS, RANCHERS, CONSUMERS, AND COMMUNITIES, AND THAT HAVE STRONG EDUCATIONAL AND COMMUNITY ENGAGEMENT COMPONENTS. WAES SEEKS TO INCREASE RESEARCH ENGAGEMENT BY COLLABORATING WITH DIVERSE RESEARCH PARTNERS WITH MUTUAL INTERESTS; INCREASING RE SEARCH INTEGRATED WITH OTHER COLLEGE MISSION AREAS; AND ENHANCING RESEARCH RELEVANCE BY CONTINUING TO UPDATE AND EXPAND WYOMING PRODUCTION AGRICULTURE RESEARCH PRIORITIES. TO THAT END, WAES COLLABORATES WITH COLLEGE RESEARCH FACULTY IN NINE DEPARTMENTS-AGRICULTURAL <(>&<)> APPLIED ECONOMICS, ANIMAL SCIENCE, BOTANY, ECOSYSTEM SCIENCE <(>&<)> MANAGEMENT, FAMILY AND CONSUMER SCIENCES, MOLECULAR BIOLOGY, PLANT SCIENCES, VETERINARY SCIENCES, AND ZOOLOGY <(>&<)> PHYSIOLOGY-TO CONDUCT HATCH-FUNDED PROJECTS ADDRESSING AT LEAST ONE OF FOUR CRITICAL ISSUES: 1) COMMUNITIES, FAMILIES <(>&<)> YOUTH; 2) COMMUNITY SOCIO-ECONOMIC PROSPERITY; 3) HUMAN HEALTH, WELLNESS <(>&<)> NUTRITION; AND 4) NATURAL SYSTEMS, FOOD <(>&<)> FIBER PRODUCTION. HATCH PROJECT PROPOSALS ARE SUBMITTED TO THE NATIONAL INSTITUTE OF FOOD AND AGRICULTURE (NIFA) FOR FINAL APPROVAL AFTER A RIGOROUS PEER REVIEW PROCESS, AND APPROVAL BY THE ASSOCIATE DEAN AND DIRECTOR OF THE WYOMING AGRICULTURAL EXPERIMENT STATION. NIFA-APPROVED PROJECTS ARE UPLOADED INTO THE NIFA REPORTING SYSTEM (NRS) WHERE PROJECT RESULTS ARE REPORTED ON AN ANNUAL BASIS AND NIFA AGAIN REVIEWS AND APPROVES THESE SUBMISSIONS. THIS MULTISTEP PEER-REVIEW, EVALUATION, RESULTS REPORTING, AND APPROVAL PROCESS ENSURES THAT PROJECTS ARE RELEVANT, METHODOLOGICALLY SOUND, AND MEET THE CRITERIA REQUIRED FOR FUNDING UNDER HATCH GUIDELINES.

HATCH-REGULAR CAPACITY

NATIONAL TRAINING INITIATIVE- SUPPORTING CHILDREN IMPACTED BY THE OPIOID EPIDEMIC (SCOPE)

HATCH-REGULAR CAPACITY FY22

THE PURPOSE OF HATCH CAPACITY FUNDING IS TO CONDUCT AGRICULTURAL RESEARCH PROGRAMS AT STATE AGRICULTURAL EXPERIMENT STATIONS IN THE 50 STATES, THE DISTRICT OF COLUMBIA, AND THE INSULAR AREAS. HATCH ACTIVITIES ARE BROAD AND INCLUDE RESEARCH ON ALL ASPECTS OF AGRICULTURE, INCLUDING SOIL AND WATER CONSERVATION AND USE; PLANT AND ANIMAL PRODUCTION, PROTECTION, AND HEALTH; PROCESSING, DISTRIBUTION, SAFETY, MARKETING, AND UTILIZATION OF FOOD AND AGRICULTURAL PRODUCTS; FORESTRY, INCLUDING RANGE MANAGEMENT AND RANGE PRODUCTS; MULTIPLE USE OF FOREST RANGELANDS, AND URBAN FORESTRY; AQUACULTURE; HOME ECONOMICS; HUMAN NUTRITION; RURAL AND COMMUNITY DEVELOPMENT AS IT RELATES TO AGRICULTURE; SUSTAINABLE AGRICULTURE; AND MOLECULAR BIOLOGY AND BIOTECHNOLOGY INASMUCH AS WORK CAN CONTRIBUTE TO AGRICULTURAL ADVANCEMENTS. WAES IS CONCERNED WITH FINDING SOLUTIONS TO CONTEMPORARY ISSUES AFFECTING WYOMING AND THE REGION THROUGH HIGH-QUALITY RESEARCH, CREATIVE SCHOLARSHIP, RESPONSIVE SERVICE, AND STATEWIDE ENGAGEMENT, EMPOWERING THE PEOPLE OF WYOMING TO MAKE CHOICES THAT ENHANCE THEIR QUALITY OF LIFE. WAES USES HATCH FUNDING TO SUPPORT FUNDAMENTAL AND APPLIED RESEARCH ON AGRICULTURAL, NATURAL, AND COMMUNITY RESOURCE ISSUES RELATED TO THE CURRENT AND FUTURE NEEDS OF WYOMING, THE REGION, THE NATION, AND THE WORLD. WAES MAINTAINS FOUR RESEARCH AND EXTENSION (R<(>&<)>E) CENTERS AROUND THE STATE THAT CONDUCT RESEARCH PROJECTS FOCUSED ON PRIORITIES AND SERVICES OF INTEREST TO FARMERS, RANCHERS, CONSUMERS, AND COMMUNITIES, AND THAT HAVE STRONG EDUCATIONAL AND COMMUNITY ENGAGEMENT COMPONENTS. WAES SEEKS TO INCREASE RESEARCH ENGAGEMENT BY COLLABORATING WITH DIVERSE RESEARCH PARTNERS WITH MUTUAL INTERESTS; INCREASING RE SEARCH INTEGRATED WITH OTHER COLLEGE MISSION AREAS; AND ENHANCING RESEARCH RELEVANCE BY CONTINUING TO UPDATE AND EXPAND WYOMING PRODUCTION AGRICULTURE RESEARCH PRIORITIES. TO THAT END, WAES COLLABORATES WITH COLLEGE RESEARCH FACULTY IN NINE DEPARTMENTS-AGRICULTURAL <(>&<)> APPLIED ECONOMICS, ANIMAL SCIENCE, BOTANY, ECOSYSTEM SCIENCE <(>&<)> MANAGEMENT, FAMILY AND CONSUMER SCIENCES, MOLECULAR BIOLOGY, PLANT SCIENCES, VETERINARY SCIENCES, AND ZOOLOGY <(>&<)> PHYSIOLOGY-TO CONDUCT HATCH-FUNDED PROJECTS ADDRESSING AT LEAST ONE OF FOUR CRITICAL ISSUES: 1) COMMUNITIES, FAMILIES <(>&<)> YOUTH; 2) COMMUNITY SOCIO-ECONOMIC PROSPERITY; 3) HUMAN HEALTH, WELLNESS <(>&<)> NUTRITION; AND 4) NATURAL SYSTEMS, FOOD <(>&<)> FIBER PRODUCTION. HATCH PROJECT PROPOSALS ARE SUBMITTED TO THE NATIONAL INSTITUTE OF FOOD AND AGRICULTURE (NIFA) FOR FINAL APPROVAL AFTER A RIGOROUS PEER REVIEW PROCESS, AND APPROVAL BY THE ASSOCIATE DEAN AND DIRECTOR OF THE WYOMING AGRICULTURAL EXPERIMENT STATION. NIFA-APPROVED PROJECTS ARE UPLOADED INTO THE NIFA REPORTING SYSTEM (NRS) WHERE PROJECT RESULTS ARE REPORTED ON AN ANNUAL BASIS AND NIFA AGAIN REVIEWS AND APPROVES THESE SUBMISSIONS. THIS MULTISTEP PEER-REVIEW, EVALUATION, RESULTS REPORTING, AND APPROVAL PROCESS ENSURES THAT PROJECTS ARE RELEVANT, METHODOLOGICALLY SOUND, AND MEET THE CRITERIA REQUIRED FOR FUNDING UNDER HATCH GUIDELINES.

GRADUATE RESEARCH FELLOWSHIP PROGRAM (GRFP)

HATCH-REGULAR CAPACITY FY21

THE PURPOSE OF HATCH CAPACITY FUNDING IS TO CONDUCT AGRICULTURAL RESEARCH PROGRAMS AT STATE AGRICULTURAL EXPERIMENT STATIONS IN THE 50 STATES, THE DISTRICT OF COLUMBIA, AND THE INSULAR AREAS. HATCH ACTIVITIES ARE BROAD AND INCLUDE RESEARCH ON ALL ASPECTS OF AGRICULTURE, INCLUDING SOIL AND WATER CONSERVATION AND USE; PLANT AND ANIMAL PRODUCTION, PROTECTION, AND HEALTH; PROCESSING, DISTRIBUTION, SAFETY, MARKETING, AND UTILIZATION OF FOOD AND AGRICULTURAL PRODUCTS; FORESTRY, INCLUDING RANGE MANAGEMENT AND RANGE PRODUCTS; MULTIPLE USE OF FOREST RANGELANDS, AND URBAN FORESTRY; AQUACULTURE; HOME ECONOMICS; HUMAN NUTRITION; RURAL AND COMMUNITY DEVELOPMENT AS IT RELATES TO AGRICULTURE; SUSTAINABLE AGRICULTURE; AND MOLECULAR BIOLOGY AND BIOTECHNOLOGY INASMUCH AS WORK CAN CONTRIBUTE TO AGRICULTURAL ADVANCEMENTS. WAES IS CONCERNED WITH FINDING SOLUTIONS TO CONTEMPORARY ISSUES AFFECTING WYOMING AND THE REGION THROUGH HIGH-QUALITY RESEARCH, CREATIVE SCHOLARSHIP, RESPONSIVE SERVICE, AND STATEWIDE ENGAGEMENT, EMPOWERING THE PEOPLE OF WYOMING TO MAKE CHOICES THAT ENHANCE THEIR QUALITY OF LIFE. WAES USES HATCH FUNDING TO SUPPORT FUNDAMENTAL AND APPLIED RESEARCH ON AGRICULTURAL, NATURAL, AND COMMUNITY RESOURCE ISSUES RELATED TO THE CURRENT AND FUTURE NEEDS OF WYOMING, THE REGION, THE NATION, AND THE WORLD. WAES MAINTAINS FOUR RESEARCH AND EXTENSION (R<(>&<)>E) CENTERS AROUND THE STATE THAT CONDUCT RESEARCH PROJECTS FOCUSED ON PRIORITIES AND SERVICES OF INTEREST TO FARMERS, RANCHERS, CONSUMERS, AND COMMUNITIES, AND THAT HAVE STRONG EDUCATIONAL AND COMMUNITY ENGAGEMENT COMPONENTS. WAES SEEKS TO INCREASE RESEARCH ENGAGEMENT BY COLLABORATING WITH DIVERSE RESEARCH PARTNERS WITH MUTUAL INTERESTS; INCREASING RE SEARCH INTEGRATED WITH OTHER COLLEGE MISSION AREAS; AND ENHANCING RESEARCH RELEVANCE BY CONTINUING TO UPDATE AND EXPAND WYOMING PRODUCTION AGRICULTURE RESEARCH PRIORITIES. TO THAT END, WAES COLLABORATES WITH COLLEGE RESEARCH FACULTY IN NINE DEPARTMENTS-AGRICULTURAL <(>&<)> APPLIED ECONOMICS, ANIMAL SCIENCE, BOTANY, ECOSYSTEM SCIENCE <(>&<)> MANAGEMENT, FAMILY AND CONSUMER SCIENCES, MOLECULAR BIOLOGY, PLANT SCIENCES, VETERINARY SCIENCES, AND ZOOLOGY <(>&<)> PHYSIOLOGY-TO CONDUCT HATCH-FUNDED PROJECTS ADDRESSING AT LEAST ONE OF FOUR CRITICAL ISSUES: 1) COMMUNITIES, FAMILIES <(>&<)> YOUTH; 2) COMMUNITY SOCIO-ECONOMIC PROSPERITY; 3) HUMAN HEALTH, WELLNESS <(>&<)> NUTRITION; AND 4) NATURAL SYSTEMS, FOOD <(>&<)> FIBER PRODUCTION. HATCH PROJECT PROPOSALS ARE SUBMITTED TO THE NATIONAL INSTITUTE OF FOOD AND AGRICULTURE (NIFA) FOR FINAL APPROVAL AFTER A RIGOROUS PEER REVIEW PROCESS, AND APPROVAL BY THE ASSOCIATE DEAN AND DIRECTOR OF THE WYOMING AGRICULTURAL EXPERIMENT STATION. NIFA-APPROVED PROJECTS ARE UPLOADED INTO THE NIFA REPORTING SYSTEM (NRS) WHERE PROJECT RESULTS ARE REPORTED ON AN ANNUAL BASIS AND NIFA AGAIN REVIEWS AND APPROVES THESE SUBMISSIONS. THIS MULTISTEP PEER-REVIEW, EVALUATION, RESULTS REPORTING, AND APPROVAL PROCESS ENSURES THAT PROJECTS ARE RELEVANT, METHODOLOGICALLY SOUND, AND MEET THE CRITERIA REQUIRED FOR FUNDING UNDER HATCH GUIDELINES.

SMITH LEVER 3B AND 3C

INTEGRATION OF XENOPUS EXTRACT AND MICROFLUIDICS TO STUDY ORGANELLE SIZE SCALING

NEUROPEPTIDE REGULATION OF NEUROHYPOPHYSEAL FUNCTION

SMITH LEVER 3(B) AND (C)

MECHANICS OF BIPOLAR MITOTIC SPINDLE ASSEMBLY

COLLEGE ACCESS CHALLENGE GRANT PROGRAM

COLLEGE ACCESS CHALLENGE GRANT PROGRAM

HATCH REGULAR

REGULATION OF ENDOMETRIAL PROLIFERATION BY THE PGRMC FAMILY - PROJECT SUMMARY/ABSTRACT PROGESTERONE RECEPTOR MEMBRANE COMPONENT (PGRMC) 1 AND PGRMC2 ARE THOUGHT TO MEDIATE PROGESTERONE ACTIONS. OUR LAB RECENTLY FLOXED THE MURINE PGRMC1 AND PGRMC2 GENES IN AN EFFORT TO EVALUATE THE FUNCTION OF THESE GENES IN THE CONTEXT OF FEMALE FERTILITY. MUTAGENESIS STUDIES USING PGR-CRE MICE REVEALED THAT PGRMC1 AND PGRMC2 ARE ESSENTIAL FOR FEMALE FERTILITY IN THAT CONDITIONAL ABLATION OF EACH GENE RESULTS IN SUBFERTILITY THAT PROGRESSES TO PREMATURE REPRODUCTIVE SENESCENCE. DESPITE BEING A PURPORTED PROGESTERONE RECEPTOR, ENDOMETRIAL PGRMC1 EXPRESSION IS ACTUALLY HIGHEST DURING THE PROLIFERATIVE, ESTRADIOL (E2)-DOMINATED PHASE OF THE MENSTRUAL CYCLE IN HUMANS AND PRIMATES. THE EVOLUTIONARY ORIGIN OF THE PGRMC FAMILY PREDATES THE APPEARANCE OF STEROLS AS SIGNALING MOLECULES BY AT LEAST 300 MILLION YEARS. AS SUCH, IT IS NOW BECOMING CLEAR THAT PGRMCS HAVE BOTH PROGESTERONE-DEPENDENT AND PROGESTERONE-INDEPENDENT FUNCTIONS. AN EVALUATION OF ESTROGENIC RESPONSES IN PGRMC1D/D, PGRMC2D/D, AND PGRMC1/2D/D MICE REVEALED THAT PGRMC PROTEINS ARE FUNDAMENTALLY REQUIRED FOR E2-INDUCED ENDOMETRIAL EPITHELIAL CELL PROLIFERATION. FURTHERMORE, WE DETERMINED THAT PGRMC1 EXPRESSION IS ELEVATED IN HUMAN ENDOMETRIAL CANCER. CONSISTENT WITH THESE FINDINGS, HUMAN ENDOMETRIAL XENOGRAFT TUMORS DERIVED FROM PGRMC1 OVER-EXPRESSING CELLS GROW FASTER AND ARE MORE RESISTANT TO CHEMOTHERAPY TREATMENT. RECENT PROTEOMIC EFFORTS IN OUR LAB HAVE ESTABLISHED THAT PGRMC1 INTERACTS WITH THREE PRINCIPAL GROUPS OF PROTEINS, AND THESE INCLUDE GLYCOLYTIC ENZYMES, RNA-BINDING PROTEINS AND PROTEINS INVOLVED IN THE INITIATION OF TRANSLATION. ESTROGEN IS KNOWN TO INDUCE AN ENDOMETRIAL WARBURG-LIKE GLYCOLYTIC EFFECT. OUR CENTRAL HYPOTHESIS IS THAT PGRMC FAMILY MEMBERS HELP COORDINATE E2-INDUCED ENDOMETRIAL CELL PROLIFERATION THROUGH THEIR INTERACTIONS WITH RNA-BINDING PROTEINS AND BY ESTABLISHING A WARBURG-LIKE AEROBIC GLYCOLYTIC STATE TO ENSURE THAT SUFFICIENT ANABOLIC CARBON-BASED BUILDING MATERIALS ARE AVAILABLE FOR PROLIFERATION AND EXPANSION OF THE TISSUE DURING THE PROLIFERATIVE PHASE OF THE MENSTRUAL/ESTROUS CYCLE. A LINKED COMPONENT OF THIS HYPOTHESIS IS THAT PGRMC FAMILY MEMBERS REGULATE MRNA PROCESSING THAT FAVORS WARBURG-LIKE GLYCOLYSIS. THROUGH THE USE OF PROTEOMICS, PRIMARY CELL CULTURES, MOUSE MODELS DESIGNED FOR EVALUATING ENDOMETRIAL EPITHELIAL CELL PROLIFERATION IN VIVO, DEVELOPMENT OF A NOVEL TRANSGENIC MOUSE, AND RNA-SEQ/CLIP-SEQ ANALYSIS, THIS HYPOTHESIS WILL BE TESTED IN THE FOLLOWING SPECIFIC AIMS: 1) EVALUATE THE CONSEQUENCES OF PGRMC1 OVER-EXPRESSION ON FEMALE FERTILITY AND DEVELOPMENT OF ENDOMETRIAL HYPERPLASIA AND CANCER; 2) DEMONSTRATE THAT PGRMC1 CONTRIBUTES TO E2-INDUCED PROLIFERATION BY ESTABLISHING A WARBURG-LIKE GLYCOLYTIC EFFECT IN ENDOMETRIAL EPITHELIAL CELLS; AND 3) DEMONSTRATE THAT PGRMC1 MEDIATES AT LEAST SOME OF THE PROLIFERATIVE ACTIONS OF E2 IN ENDOMETRIAL EPITHELIAL CELLS THROUGH ITS INTERACTIONS WITH RNA-BINDING PROTEINS THAT COORDINATE POST-TRANSCRIPTIONAL MRNA PROCESSING AND TRANSLOCATION TO THE POLYRIBOSOME. THE OUTCOME OF THESE MECHANISTIC STUDIES WILL PROVIDE NOVEL INFORMATION ABOUT THE MOLECULAR DETAILS OF PGRMC1 FUNCTIONS THAT MAY BE USEFUL IN THE DEVELOPMENT OF COUNTERMEASURES THAT COULD REDUCE THE PREVALENCE AND/OR SEVERITY OF E2-DRIVEN ENDOMETRIAL DISEASES.

WYOMING SBDC CARES ACT

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EQUIPMENT: MRI:TRACK I ACQUISITION OF A SUPER-RESOLUTION FLUORESCENCE LIFETIME IMAGING MICROSCOPE TO TRACK MOLECULAR DYNAMICS IN LIVING ORGANISMS -AN AWARD IS MADE TO THE UNIVERSITY OF WYOMING (UWYO) TO SUPPORT THE ACQUISITION OF A STELLARIS8 FALCON STED SUPER-RESOLUTION FLUORESCENCE LIFETIME CONFOCAL MICROSCOPE. THIS ADVANCED IMAGING SYSTEM WILL SIGNIFICANTLY ENHANCE RESEARCH CAPACITY AT UWYO, BUILDING ON THE UNIVERSITY?S RECENT $100 MILLION INVESTMENT IN STEM RESEARCH INFRASTRUCTURE. THE INSTRUMENT WILL ALSO PLAY A TRANSFORMATIVE ROLE IN EDUCATION AND OUTREACH. IT WILL PROVIDE HANDS-ON TRAINING OPPORTUNITIES FOR UNDERGRADUATE AND GRADUATE STUDENTS ACROSS WYOMING AND NEIGHBORING STATES, WHILE SUPPORTING K?14 STEM ENGAGEMENT THROUGH ESTABLISHED PARTNERSHIPS WITH LOCAL SCHOOLS AND COMMUNITY COLLEGES. HIGH SCHOOL STUDENTS AND TEACHERS THROUGHOUT THE STATE WILL BENEFIT THROUGH WORKSHOPS AND OUTREACH INITIATIVES. THE UNIVERSITY IS COMMITTED TO MAINTAINING THIS INSTRUMENT WITH DEDICATED TECHNICAL SUPPORT AND INTEGRATING IT INTO EXISTING FACILITIES FOR IMAGING, PLANT GROWTH, AND DATA ANALYSIS. THE MICROSCOPE WILL ENABLE RESEARCHERS TO EXPLORE CELLULAR AND MOLECULAR PROCESSES IN REAL TIME, ESPECIALLY UNDER CHANGING ENVIRONMENTAL CONDITIONS. IT WILL PROMOTE INTERDISCIPLINARY COLLABORATIONS, EXPAND SCIENTIFIC CAPABILITIES, AND OPEN NEW AVENUES FOR DISCOVERY ACROSS FIELDS SUCH AS PLANT BIOLOGY, MICROBIOLOGY, AND ENVIRONMENTAL SCIENCES. IT WILL FACILITATE MAJOR ADVANCES IN UNDERSTANDING PLANT HEALTH, MICROBIAL INTERACTIONS, AND SURVIVAL MECHANISMS IN EXTREME ENVIRONMENTS. SUPPORTING RESEARCH AT BOTH UWYO AND COLORADO STATE UNIVERSITY, THE MICROSCOPE IS EXPECTED TO SERVE MORE THAN 20 RESEARCH GROUPS WITHIN A FEW YEARS AND BECOME A KEY RESOURCE FOR SCIENTIFIC INNOVATION IN THE REGION. BY MAKING THIS POWERFUL TECHNOLOGY BROADLY ACCESSIBLE, THE PROJECT WILL HELP TRAIN THE NEXT GENERATION OF SCIENTISTS AND ENGINEERS AND CONTRIBUTE TO DISCOVERIES THAT IMPROVE OUR UNDERSTANDING OF LIFE AND BENEFIT SOCIETY AS A WHOLE. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

MECHANICS OF MICROTUBULE ASTER GROWTH AND POSITIONING

EDUCATIONAL OPPORTUNITY CENTERS PROGRAM

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COLLEGE ACCESS CHALLENGE GRANT PROGRAM

WYOMING HIGH ALTITUDE BRILLIANT PATHWAYS RURAL EDUCATION PROGRAM

DEFINING THE ROLE OF BRAIN IRON DYSREGULATION IN HUNTINGTON'S DISEASE

MRI: DEVELOPMENT OF A MULTI-FUNCTION AIRBORNE RAMAN LIDAR FOR ATMOSPHERIC PROCESS STUDIES

VISUALIZATION BASICS: USING GAMING TO IMPROVE COMPUTATIONAL THINKING (UGAME-ICOMPUTE)

EARTHCUBE DATA CAPABILITIES: SOLUTIONS FOR PALEOBOTANY: A WEB CLIENT HOSTING NOVEL CONTENT AND ITS INTEGRATION WITH EXISTING DATABASES

THE BESSIE COLEMAN PROJECT - USING COMPUTER MODELING AND FLIGHT SIMULATION TO CREATE STEM PATHWAYS

DE-FE0031855 UNIVERSITY OF WYOMING PROJECT TITLE: ''RESOURCE RECOVERY AND ENVIRONMENTAL PROTECTION IN WYOMING’S GREATER GREEN RIVER BASIN USING SELECTIVE NANOSTRUCTURED MEMBRANES''

DE-FE0029375 - INTEGRATED COMMERCIAL CARBON CAPTURE AND STORAGE PREFEASIBILITY STUDY AT DRY FORK STATION, WYOMING

SUSTAINING WYOMING'S ADVANCING REACH IN MATHEMATICS AND SCIENCE (SWARMS)

DE-FE0029302 PROJECT ENTITLED INTEGRATED PRE-FEASIBILITY STUDY OF A COMMERCIAL-SCALE COMMERCIAL CARBON CAPTURE PROJECT IN FORMATIONS OF THE ROCK SPRINGS UPLIFT, WYOMING.

EVALUATING THE INFLUENCE OF ENERGY DEVELOPMENT ON MULE DEER MIGRATIONS

UPWARD BOUND MATH AND SCIENCE COMPETITION

UROL: EPIGENETICS 2: COLLABORATIVE RESEARCH: BUMBLE BEE COLD TOLERANCE ACROSS ELEVATIONS - FROM EPIGENOTYPE TO PHENOTYPE ACROSS SPACE, TIME, AND LEVELS OF BIOLOGICAL ORGANIZATION

TAS::89 0222::TAS; NEW; X-RAY DIFFRACTION AND NEUTRON SCATTERING STRUCTURAL ANALYSIS OF NATURAL AND SYNTHETIC SPIDER SILK FIBERS; PI-RANDOLPH V LEWIS

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THE UNIVERSITY OF WYOMINGS WYOMING SURVEY & ANALYSIS CENTER (WYSAC) PROPOSES A 3-YEAR PROJECT THAT INCLUDES CONDUCTING A NONPARTICIPATING STATE PROFILE ASSESSMENT, DESIGNING A NONPARTICIPATING STATE PLAN, AND CREATING A MONITORING WORK PLAN. DURING THE PROJECT PERIOD, WYSAC WILL RESUME COMPLIANCE INSPECTIONS OF JAILS, LOCKUPS, SECURE DETENTION FACILITIES, AND SECURE CORRECTIONAL FACILITIES; SUBAWARD FUNDS TO LOCAL GOVERNMENT ORGANIZATIONS AND YOUTH-SERVING ORGANIZATIONS TO FUND ACTIVITIES RELATED TO THE CORE REQUIREMENTS; COLLECT JUVENILE JUSTICE SYSTEM DATA; AND REPORT TO OJJDP ABOUT THE STATES PROGRESS TOWARD MEETING THE STANDARDS OF THE CORE REQUIREMENTS.

EDUCATIONAL OPPORTUNITY CENTERS PROGRAM

RONALD E. MCNAIR POSTBACCALAUREATE ACHIEVEMENT

ADVANCED NURSING EDUCATION GRANTS

N-GLYCOSYLATION MECHANISM IN INSECT CELLS

COLLABORATIVE RESEARCH: FEC: OPTICAL PROPERTIES OF MINERAL DUST AEROSOLS: BUILDING CAPACITY FOR USE-INSPIRED APPLICATIONS THROUGH EXPERIMENTAL AND THEORETICAL INVESTIGATIONS -MINERAL DUST AEROSOLS ARE SMALL PARTICLES COMMONLY SUSPENDED IN THE EARTH?S ATMOSPHERE WITH IMPORTANT IMPLICATIONS FOR WEATHER AND CLIMATE, ECOSYSTEMS, HUMAN HEALTH AND VISIBILITY, AND OPTICAL COMMUNICATION AND REMOTE SENSING SYSTEMS. UNFORTUNATELY, VERY LITTLE IS KNOWN ABOUT THE OPTICAL PROPERTIES OF MINERAL DUST AND HOW THEY RELATE TO DUST SOURCES AND PROPERTIES. THIS UNDERSTANDING IS NECESSARY TO COMPREHEND THE ROLES AND IMPACTS OF MINERAL DUST AEROSOLS ON HUMAN AND NATURAL SYSTEMS. THIS PROJECT AIMS TO BUILD CAPACITY TOWARD USE-INSPIRED RESEARCH BY GAINING SUCH UNDERSTANDING THROUGH INTEGRATED EXPERIMENTAL AND THEORETICAL INVESTIGATIONS OF MINERAL DUST OPTICAL PROPERTIES. THIS WILL BE OF THE ESSENCE FOR QUANTIFYING MINERAL DUST ON GLOBAL AND REGIONAL SCALES, MINERAL DUST EFFECTS ON WEATHER AND CLIMATE, AND THEIR IMPACTS ON HUMAN AND NATURAL SYSTEMS. THE PROJECT WILL BUILD A THREE-STATE COLLABORATIVE TEAM TO DEVELOP AND DEMONSTRATE CAPACITY FOR USE-INSPIRED RESEARCH BY ADVANCING KNOWLEDGE ON THE OPTICAL PROPERTIES OF MINERAL DUST AEROSOLS IN THE ATMOSPHERE. USE-INSPIRED APPLICATIONS INCLUDE IMPROVING OPTICAL REMOTE AND IN SITU SENSING OF MINERAL DUST AEROSOLS. ADDITIONAL APPLICATIONS INCLUDE QUANTIFYING MINERAL DUST IMPACTS ON HUMAN AND MACHINE VISIBILITY FOR SAFE OPERATION OF CARS AND AIRPLANES AND ON NATIONAL DEFENSE (E.G., OPTICAL RANGE FINDERS AND TARGET DESIGNATORS) AND EFFECTS OF INHALED MINERAL DUST ON HUMAN HEALTH (E.G., RESPIRATORY AND PULMONARY DISEASE AND MORTALITY). MINERAL DUST AEROSOLS DOMINATE AEROSOL MASS AND AEROSOL OPTICAL DEPTH IN THE EARTH?S ATMOSPHERE WITH IMPORTANT IMPLICATIONS FOR RADIATIVE FORCING AND CLIMATE, FERTILIZATION OF AQUATIC AND TERRESTRIAL ECOSYSTEMS, HUMAN HEALTH AND VISIBILITY, AND OPTICAL COMMUNICATION AND REMOTE SENSING SYSTEMS. UNFORTUNATELY, VERY LITTLE IS KNOWN ABOUT MINERAL DUST OPTICAL PROPERTIES AND HOW THEY RELATE TO DUST SOURCES AND DUST PHYSICAL, CHEMICAL, AND MINERALOGICAL PROPERTIES AS NEEDED TO UNDERSTAND THE ROLES AND IMPACTS OF MINERAL DUST AEROSOLS IN THE EARTH SYSTEM. PROJECT OUTCOMES HAVE POTENTIAL TO BUILD CAPACITY TOWARD USE-INSPIRED RESEARCH BY GAINING SUCH UNDERSTANDING THROUGH INTEGRATED EXPERIMENTAL AND THEORETICAL INVESTIGATIONS OF MINERAL DUST OPTICAL PROPERTIES. THIS WILL BE OF THE ESSENCE FOR QUANTIFYING THE GLOBAL AND REGIONAL MINERAL DUST CYCLES, MINERAL DUST DIRECT RADIATIVE FORCING, AND THEIR IMPACTS ON HUMAN AND NATURAL SYSTEMS WITH OPTICAL REMOTE AND IN SITU MEASUREMENTS, THEREBY ADDRESSING KEY NATIONAL CRITICAL AND EMERGING TECHNOLOGIES. THIS PROJECT AIMS TO BUILD ON RESEARCH EXCELLENCE AND STAKEHOLDERS IN THREE EPSCOR JURISDICTIONS (NEVADA, OKLAHOMA, AND WYOMING) WITH THE FOLLOWING JURISDICTIONS/PARTNER INSTITUTIONS INVOLVED: NEVADA (NV): DESERT RESEARCH INSTITUTE (DRI: OVERALL AND NV LEAD INSTITUTION) AND TRUCKEE MEADOWS COMMUNITY COLLEGE (TMCC: NV SUB-AWARDEE); OKLAHOMA (OK): UNIVERSITY OF OKLAHOMA (OU: OK LEAD INSTITUTION); WYOMING (WY): UNIVERSITY OF WYOMING (UW: WY LEAD INSTITUTION) AND CENTRAL WYOMING COLLEGE (CWC: WY SUB-AWARDEE). THE PROJECT COMBINES A BREADTH OF STRENGTHS OF THE THREE COLLABORATING JURISDICTIONS, INCLUDING 1) EXPERIMENTAL AEROSOL OPTICS EXPERIENCE, INSTRUMENTS, AND FACILITIES AT DRI; 2) AVAILABILITY OF THE UNIQUE AND WELL-CHARACTERIZED DRI GLOBAL MINERAL DUST COLLECTION, 3) LEADING THEORETICAL LIGHT-SCATTERING COMPUTATIONAL CAPABILITIES AND EXPERTISE AT UW, 4) CAPABILITIES IN APPLIED MATHEMATICS AT TMCC, AND 5) LEADING STRENGTHS IN AEROSOL REMOTE SENSING AT OU. THIS PROJECT IS SUPPORTED BY THE EPSCOR RESEARCH INFRASTRUCTURE IMPROVEMENT PROGRAM: FOCUSED EPSCOR COLLABORATIONS PROGRAM (FEC), WHICH SUPPORTS INTERJURISDICTIONAL TEAMS OF EPSCOR INVESTIGATORS TO PERFORM RESEARCH IN TOPICS THAT ALIGN WITH NSF PRIORITIES, WITH THE GOALS OF DRIVING DISCOVERY AND BUILDING SUSTAINABLE STEM CAPACITY. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE PLANNED FOR THIS AWARD.

PRYOR MOUNTAIN WIND ENERGY AND SAGE-GROUSE STUDY

INTEGRATED CHARACTERIZATION OF CO2 STORAGE RESERVOIRS ON THE ROCK SPRINGS UPLIFT COMBINING GEOMECHANICS, GEOCHEMISTRY, AND FLOW MODELING

GENOMIC AND ECO-PHYSIOLOGICAL MECHANISMS OF HYPOXIA RESISTANCE IN MOUNTAIN HUMMINGBIRDS -HIGH-ELEVATION ENVIRONMENTS ARE DEFINED BY THIN AIR AND BITING COLD THAT DEMAND EXCEPTIONAL PHYSIOLOGICAL RESILIENCE. UNDERSTANDING HOW ORGANISMS ACCLIMATIZE AND ADAPT TO THESE CHALLENGES IS KEY TO UNCOVERING HOW THEY WILL RESPOND TO FUTURE ENVIRONMENTAL CONDITIONS. THIS STUDY WILL EXAMINE HOW DIFFERENT POPULATIONS OF TWO SPECIES OF MOUNTAIN HUMMINGBIRDS VARY IN THEIR GENETIC, BEHAVIORAL, AND PHYSIOLOGICAL RESPONSES TO TEMPERATURE AND OXYGEN SCARCITY. THE RESEARCHERS WILL USE INTEGRATIVE APPROACHES IN THE FIELD AND THE LAB TO STUDY POPULATIONS DISTRIBUTED ACROSS A RANGE OF LATITUDES AND ELEVATIONS, SOME OF WHICH RESIDE IN THESE LOCATIONS YEAR-ROUND, AND SOME OF WHICH MIGRATE UP AND DOWN MOUNTAINS SEASONALLY. RESULTS WILL PROVIDE NEW INSIGHT INTO CURRENT AND FUTURE POPULATION RESILIENCE. THIS PROJECT WILL PROVIDE HANDS-ON TRAINING FOR EARLY-CAREER SCIENTISTS, OUTREACH OPPORTUNITIES, AND NEW SKILL-BUILDING WORKSHOPS. IT WILL ADDITIONALLY FOSTER INTERNATIONAL MUSEUM COLLABORATIONS, GROW MUSEUM COLLECTIONS, AND BUILD NATURAL HISTORY INFRASTRUCTURE. TOGETHER, THE INTERWOVEN SCIENTIFIC AND SOCIAL IMPACTS OF THIS PROJECT WILL CONTRIBUTE TO WORKFORCE DEVELOPMENT, CONNECTING SCIENCE AND SOCIETY THROUGH EDUCATION AND OUTREACH. THIS PROJECT ADDRESSES LONG-STANDING QUESTIONS IN ECOLOGY, EVOLUTION, AND PHYSIOLOGY: HOW DOES EXPOSURE TO ENVIRONMENTAL CHALLENGES SHAPE MOLECULAR AND PHYSIOLOGICAL RESPONSE MECHANISMS, AND HOW CAN WE PREDICT FUTURE RESPONSE CAPACITY? THIS RESEARCH WILL FURTHER OUR UNDERSTANDING OF HOW THERMAL AND HYPOXIC STRESS SHAPE GENOMIC ARCHITECTURE, IMPACT PHYSIOLOGY, AND ULTIMATELY, AFFECT ORGANISMAL PERFORMANCE AND PERSISTENCE IN MOUNTAIN ENVIRONMENTS. THE PROJECT WILL PROVIDE EMPIRICAL TESTS OF THEORY, INTEGRATIVE STUDY OF CAUSE-AND-EFFECT-RELATIONSHIPS, AND PREDICTIVE FORECASTING IN A COMPARATIVE ORGANISMAL FRAMEWORK. IT BREAKS NEW GROUND BY CREATIVELY INTEGRATING: 1) FIELD EXPERIMENTS WITH WILD HUMMINGBIRDS TO TEST FUNCTIONAL PERFORMANCE; 2) LARGE-SCALE ANALYSES OF POPULATION GENOMIC ADAPTATION; AND 3) NEW PREDICTIVE MODELS. COLLECTIVELY, THIS PROJECT PROVIDES A MULTI-SCALE FRAMEWORK FOR LINKING MECHANISM TO PERFORMANCE THAT WILL ADVANCE HOW WE STUDY ADAPTIVE RESPONSES UNDER ENVIRONMENTAL EXTREMES. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

DEVELOPMENT OF AUDITORY RESPONSE SELECTIVITY

COLLABORATIVE RESEARCH: RII FEC: HARNESSING CONTROLLED ENVIRONMENT AGRICULTURE TO SECURE SUSTAINABILITY AND ECONOMIC GROWTH -EXTREME CLIMATE EVENTS ARE INCREASING IN FREQUENCY AND HAVE HAD SIGNIFICANT, NEGATIVE IMPACTS ON CROP PRODUCTION NOT ONLY FOR INDUSTRIAL BUT ALSO FOR SMALLHOLDER FARMS. FOOD SECURITY, FOOD NUTRITIONAL QUALITY, AND THE VIABILITY OF DISADVANTAGED COMMUNITIES ARE ESPECIALLY THREATENED BY CLIMATE CHANGE. AN EDUCATED APPLICATION OF CONTROLLED ENVIRONMENT AGRICULTURE (CEA) PROVIDES ONE AVENUE TO MITIGATE CLIMATE PRESSURE ON TRIBAL COMMUNITIES AND MEET FUTURE FOOD DEMAND IN A SUSTAINABLE MANNER. ADVANCES IN AND WIDESPREAD ADOPTION OF CEA ARE, HOWEVER, LIMITED BY SEVERAL FACTORS. SIGNIFICANT KNOWLEDGE GAPS EXIST IN THE SCIENCE UNDERPINNING CEA. ADDITIONALLY, THERE HAS BEEN LIMITED INVESTMENT IN RELEVANT RESEARCH, COMMUNITY ENGAGEMENT, AND WORKFORCE DEVELOPMENT. THIS PROJECT IS A COLLABORATION AMONG COMMUNITY COLLEGES, UNIVERSITIES, TRIBAL NATIONS, AND COMMUNITY ORGANIZATIONS LOCATED IN THREE NSF EPSCOR JURISDICTIONS: UNIVERSITY OF NEW MEXICO, NEW MEXICO STATE UNIVERSITY, AND SANTA FE COMMUNITY COLLEGE (NEW MEXICO); UNIVERSITY OF WYOMING (WYOMING); AND UNIVERSITY OF SOUTH DAKOTA AND SICANGU COMMUNITY DEVELOPMENT CORPORATION (SOUTH DAKOTA). THE THREE COLLABORATING JURISDICTIONS ARE HOME TO 36 FEDERAL RESERVATIONS. THE PROJECT TEAM BRINGS TOGETHER COMMUNITY MEMBERS AND RESEARCHERS FROM DIVERSE FIELDS (E.G., ECONOMISTS, ENGINEERS, BIOLOGISTS, AND PLANT PHYSIOLOGISTS) AND CONSISTS OF EARLY-CAREER, MID-CAREER, AND ESTABLISHED RESEARCHERS. THIS PROJECT PROVIDES OPPORTUNITIES FOR LEARNING AMONG UNIVERSITIES, COMMUNITY COLLEGES, INDUSTRY, AND TRIBAL COMMUNITIES TO ALLOW FOR THE DEVELOPMENT OF TAILORED CEA SYSTEMS AND A CLIMATE-SMART AND COMMUNITY-BASED WORKFORCE. THE HUMAN AND INFORMATION INFRASTRUCTURE DEVELOPED UNDER THIS PROJECT IS ANTICIPATED TO ATTRACT AND RETAIN TALENT, STIMULATE ECONOMIC DEVELOPMENT, AND CONFER CLIMATE RESILIENCE IN TRIBAL COMMUNITIES WITHIN AND ACROSS JURISDICTIONS. THE OVERARCHING GOAL OF THIS PROJECT IS TO EMPIRICALLY DETERMINE BEST PRACTICES FOR SECURE CEA FOOD PRODUCTION AND TO QUANTIFY THE SOCIO-ECONOMIC IMPACTS OF CEA ON TRIBAL COMMUNITIES ACROSS THE COLLABORATING EPSCOR JURISDICTIONS. THE PROJECT PROPOSES TO TAKE A CONVERGENCE SCIENCE APPROACH TO TACKLING FOOD SECURITY UNDER CLIMATE CHANGE, DRAWING UPON DIVERSE EXPERTISE WITH RESEARCHERS RANGING FROM BASIC (PLANT PHYSIOLOGY AND PLANT-MICROBE INTERACTIONS) AND APPLIED BIOLOGY (CEA AND HORTICULTURE), ENVIRONMENTAL AND NATURAL RESOURCE ECONOMICS, ENGINEERING, SUSTAINABILITY SCIENCE, AND APPLIED KNOWLEDGE OF TRIBAL COMMUNITY MEMBERS. THE RESEARCH PROJECT LEVERAGES EACH INSTITUTION'S UNIQUE AND COMPLEMENTARY RESEARCH EXPERTISE AND RESOURCES TO ACCOMPLISH THE FOLLOWING THREE OBJECTIVES: (1) CHARACTERIZE HOW THE ENVIRONMENT, PLANTS, AND MICROBES INTERACT IN HYDROPONIC SYSTEMS AND AFFECT CROP YIELD AND NUTRITIONAL QUALITY; (2) IDENTIFY ENVIRONMENTAL, NUTRITIONAL, AND SOCIO-ECONOMIC DRIVERS AND IMPACTS OF CEA ON TRIBAL COMMUNITIES TO ENHANCE CLIMATE RESILIENCE STRATEGIES VIA CEA; AND (3) EMPOWER TRIBAL COMMUNITIES THROUGH INTERDISCIPLINARY TRAINING AIMED AT LONG-TERM RETENTION OF A HIGHLY-SKILLED CLIMATE-SMART CEA WORKFORCE. THE PROJECT INCLUDES TRAINING AND MENTORING ACTIVITIES FOR UNDERGRADUATE AND GRADUATE STUDENTS, POST-DOCTORAL SCHOLARS, EARLY CAREER FACULTY, AND VARIOUS TRIBAL COMMUNITIES, INCLUDING FARMERS, STUDENTS K-12, AND INDUSTRY PERSONNEL. THIS PROJECT IS FUNDED BY THE EPSCOR RESEARCH INFRASTRUCTURE IMPROVEMENT-FOCUSED EPSCOR COLLABORATIONS (RII-FEC) PROGRAM. THE RII-FEC PROGRAM BUILDS INTER-JURISDICTIONAL COLLABORATIVE TEAMS OF EPSCOR INVESTIGATORS IN FOCUS AREAS CONSISTENT WITH THE NSF STRATEGIC PLAN. RII-FEC PROJECTS INCLUDE RESEARCHERS FROM AT LEAST TWO EPSCOR JURISDICTIONS WITH COMPLEMENTARY EXPERTISE AND RESOURCES NECESSARY TO ADDRESS CHALLENGES, WHICH NEITHER PARTY COULD ADDRESS AS WELL OR AS RAPIDLY INDEPENDENTLY. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

THE CIRCUIT BASIS OF SUNDOWNING-RELATED CIRCADIAN DYSFUNCTION IN ALZHEIMER'S DISEASE AND ALZHEIMER'S DISEASE-RELATED DEMENTIAS - THE LONG-TERM GOAL OF THIS PROJECT IS TO GAIN AN UNDERSTANDING OF THE CIRCUIT MECHANISMS UNDERLYING CIRCADIAN DYSFUNCTION AND ASSOCIATED BEHAVIORAL DISTURBANCES IN ALZHEIMER’S DISEASE (AD) AND ALZHEIMER’S DISEASE RELATED DEMENTIAS (ADRD). AD/ADRD ARE ASSOCIATED WITH PROGRESSIVE DISRUPTION OF CIRCADIAN RHYTHMS, INCLUDING BODY TEMPERATURE, LOCOMOTOR ACTIVITY, AND OTHER RHYTHMS, COMPARED TO HEALTHY AGED-MATCHED CONTROLS. THIS SUGGESTS THAT AD-RELATED PATHOLOGY ALTERS THE ABILITY OF THE MASTER CIRCADIAN PACEMAKER (THE SUPRACHIASMATIC NUCLEUS OF THE HYPOTHALAMUS, SCN), TO SYNCHRONIZE SUCH RHYTHMS TO THE DAILY LIGHT-DARK CYCLE. A PARTICULAR FORM OF CIRCADIAN DYSFUNCTION IN AROUND 20% OF AD/ADRD PATIENTS IS “SUNDOWNING”, CHARACTERIZED BY AGITATION, AGGRESSION, AND WANDERING DURING THE LATE AFTERNOON AND EARLY EVENING. THE NEUROBIOLOGY OF SUNDOWNING REMAINS UNKNOWN, BUT OUR LAB HAS DEVELOPED A WORKING MODEL FOR HOW DISRUPTION OF CIRCADIAN PATHWAYS IN MICE MAY LEAD TO TEMPORAL DISTURBANCES RELEVANT TO SUNDOWNING. THE SCN IS KNOWN TO REGULATE BODY TEMPERATURE AND LOCOMOTOR ACTIVITY RHYTHMS BY A PATHWAY THROUGH ITS MAJOR POSTSYNAPTIC TARGET, THE SUBPARAVENTRICULAR ZONE (SPZ). WE RECENTLY SHOWED THAT AGGRESSION PROPENSITY IN MICE ALSO FOLLOWS A DAILY RHYTHM REGULATED BY THE SCN AND SPZ THROUGH A SEPARATE DOWNSTREAM PATHWAY. IMPORTANTLY, DISRUPTING THIS PATHWAY INCREASES AGGRESSION AROUND THE ACTIVE-TO-REST PHASE TRANSITION, WHICH IS TEMPORALLY ANALOGOUS TO WHEN SUNDOWNING PATIENTS SHOW AGITATION AND AGGRESSION. AD-ASSOCIATED DISRUPTIONS TO THE SCN, SPZ, OR THEIR INPUT PATHWAYS, MAY THUS LEAD TO DISTURBANCES IN BODY TEMPERATURE, LOCOMOTOR ACTIVITY (IN THE FORM OF WANDERING), AND ALSO SUNDOWNING-RELATED AGGRESSION. TO ADDRESS POTENTIAL MECHANISTIC CONNECTIONS BETWEEN AD-RELATED PATHOLOGY AND CIRCADIAN FUNCTION, WE CONDUCTED BEHAVIORAL AND NEUROANATOMICAL ANALYSES IN THE TAPP MOUSE MODEL OF AD. WE IDENTIFIED THE LATERAL PARABRACHIAL NUCLEUS (LPB) IN THE BRAINSTEM AS A MAJOR SITE OF PTAU, FOUND THAT THE LPB PROJECTS TO BOTH THE SCN AND SPZ, AND REVEAL STRONG EVIDENCE OF A ROLE FOR LPB PTAU IN AD-RELATED CIRCADIAN DYSFUNCTION AND AGGRESSION. HERE, WE WILL TEST OUR HYPOTHESES THAT THE LPBASCN/SPZ PATHWAY IS REQUIRED FOR NORMAL CIRCADIAN FUNCTION AND THAT PTAU IN THIS PATHWAY UNDERLIES AD- RELATED CIRCADIAN DYSFUNCTION AND SUNDOWNING-RELATED BEHAVIORAL DISTURBANCES. WE WILL USE RETROGRADE DELIVERY OF CRE RECOMBINASE FROM THE SCN AND SPZ, AND CRE-DEPENDENT VECTORS IN THE LPB TO SPECIFICALLY MANIPULATE LPBASCN/SPZ NEURONS. WE WILL DETERMINE IF CHEMOGENETIC MANIPULATIONS OF LPBASCN/SPZ NEURONS ACUTELY AMELIORATE OR EXACERBATE CIRCADIAN DYSFUNCTION AND INCREASED AGGRESSION IN TAPP MICE. WE WILL ALSO EXPRESS THE P301L MUTATION (AND SUBSEQUENTLY PTAU) IN ONLY LPBASCN/SPZ NEURONS IN WILD-TYPE MICE AND IN MICE WITH HIGH LEVELS OF A-BETA TO EXAMINE INTERACTIONS BETWEEN PTAU AND A-BETA IN THIS PATHWAY. FINALLY, WE WILL USE CRE-MOUSE LINES TO TARGET SPECIFIC LPB SUBPOPULATIONS THAT DIFFERENTIALLY PROJECT TO THE CIRCADIAN SYSTEM TO DETERMINE THEIR RESPECTIVE ROLES IN NORMAL CIRCADIAN FUNCTION AND PTAU-RELATED CIRCADIAN DYSFUNCTION.

IN SITU MEASUREMENTS OF STRATOSPHERIC AEROSOL SIZE DISTRIBUTIONS AND THEIR USE IN A NEW AEROSOL SURFACE AREA CLIMATOLOGY

TARGETED ENCAPSULATION AND INERTIAL FOCUSING FOR CIRCULATING TUMOR CELL ISOLATION

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