Accelerate

TEACHER AND LEADER PREPARATION AND PROFESSIONAL DEVELOPMENT GRANT PROGRAM

INVESTING IN INNOVATION -- DEVELOPMENT GRANTS

REAL-WORLD CLINICAL TRIAL OF AN ONLINE COGNITIVE BEHAVIORAL THERAPY FOR MANAGING FATIGUE IN MULTIPLE SCLEROSIS

INVESTING IN INNOVATION - DEVELOPMENT GRANTS

MID-ATLANTIC TECH BRIDGE

SBIR PHASE II: INTEGRATED SOLUTION FOR LOW COST DISTRIBUTED WIND ENERGY GENERATION

CHARTER SCHOOLS MANAGEMENT ORGANIZATIONS

HEERF II FOR STUDENT GRANTS

EXPANDING SYNCHROTRON APPLICATIONS IN BIOMEDICAL RESEARCH: MYOCARDIAL AND SKELETAL MUSCLE IMAGING AT BROOKHAVEN NATIONAL LABS - ABSTRACT IN SPITE OF THE RICH MOLECULAR-SCALE DATA PROVIDED, CLINICAL APPLICATIONS OF HIGH-POWERED SYNCHROTRON RADIATION FOR SKELETAL AND CARDIAC MUSCLE PHYSIOLOGY — COLLECTIVELY KNOWN AS MUSCLE SMALL-ANGLE X-RAY SCATTERING OR (MYOSAXS) — ARE LIMITED. MYOSAXS IS THE ONLY TECHNOLOGY AVAILABLE THAT DIRECTLY IMAGES SARCOMERIC PROTEIN ORGANIZATION IN LIVE TISSUE AND IS USED BOTH IN FUNDAMENTAL MUSCLE MECHANICS RESEARCH AND WITHIN THE DRUG DEVELOPMENT PIPELINE. UNFORTUNATELY, MOST APPLICATIONS STILL LIE IN ACADEMIA WHERE TYPICAL USE CASES INVOLVE COMPETITIVE ACCESS RESERVATIONS MONTHS IN ADVANCE AT ONE OF THE FEW SYNCHROTRON BEAMLINES IN THE WORLD EQUIPPED FOR NEAR-PHYSIOLOGICAL BIOLOGICAL SAMPLES. THE MAIN BARRIERS OF ENTRY ARE THUS ACCESS, LONG LEAD TIMES, AND A SHORT SUPPLY OF TRAINED LIFE-SCIENCE BEAMLINE SCIENTISTS IN THE FIELD. AS BIOLOGICAL BEAMLINE SCIENTISTS OURSELVES, WE RECOGNIZED HOW STRONGLY THESE BARRIERS LIMIT HUNDREDS OF ACADEMIC AND INDUSTRY RESEARCHERS FROM USING X-RAY SCIENCE AND SO WE FOUNDED OUR FIRM, ACCELERATED MUSCLE BIOTECHNOLOGIES, AS A SCIENCE-AS-A-SERVICE SOLUTION SPECIFICALLY FOR MYOSAXS SYNCHROTRON APPLICATIONS AND IS THE FOUNDATION OF THIS APPLICATION. FOR THIS PHASE I APPLICATION, WE PROPOSE TO DEVELOP MYOSAXS INFRASTRUCTURE AT THE LIX BEAMLINE AT BROOKHAVEN NATIONAL LABS, A SYNCHROTRON FACILITY ON LONG ISLAND NY, INITIALLY FOR ACADEMIC USERS WHO AREN'T BEAMLINE SCIENTISTS THEMSELVES BUT WISH TO ACQUIRE SARCOMERIC DATA AND HAVE MORE FLEXIBLE REQUIREMENTS ON LEAD TIMES. WE WILL EVALUATE OUR ADVANCEMENT BY STUDYING THE HIGHLY RELEVANT MECHANISM OF MAVACAMTEN ON MUSCLE, A RECENT FDA- APPROVED DRUG FOR HYPERTROPHIC CARDIOMYOPATHY THAT DIRECTLY SUPPRESSES MUSCLE MOTOR FUNCTION AND USED MYOSAXS EXPERIMENTS TO SHOW ITS' INTERACTIONS WITH SARCOMERIC PROTEINS. OUR LONG-TERM VISION HOWEVER IS FOR MYOSAXS TO BE AVAILABLE FOR CLINICAL RESEARCH WHERE HOSPITALS CAN SEND SKELETAL OR CARDIAC MUSCLE BIOPSIES FOR MOLECULAR TESTING WITH AT MOST A 1-WEEK LEAD TIME. THE PROPOSED IMPROVEMENT AT BROOKHAVEN FOCUSES ON TWO OBJECTIVES: 1) TO ACQUIRE MYOSAXS DATA COMPARABLE IN QUALITY TO THE CURRENT GOLD STANDARD IN THE FIELD AND 2) TO DEVELOP REPRODUCIBILITY AND REPEATABILITY (R&R) METRICS TO STANDARDIZE DATA QUALITY ACROSS DIFFERENT SYNCHROTRON FACILITIES. THESE OBJECTIVES ARE CRITICAL NECESSITIES FOR OUR BUSINESS STRATEGY TO USE BROOKHAVEN AS AN OPERATIONAL BASE FOR THE MULTIPLE HEALTHCARE AND ACADEMIC HUBS IN THE NORTHEAST REGIONAL AREA AND FOR FUTURE WORK AT OTHER SYNCHROTRONS. THE LESSONS LEARNED HERE ABOUT DATA QUALITY AND R&R FOR MUSCLE TISSUES ARE GENERALIZABLE TO OTHER BIOLOGICAL SAMPLES AS WELL, INCLUDING RENAL AND NERVOUS TISSUE, AND WILL SET THE PATH FOR FURTHER INNOVATIONS OF SYNCHROTRON RADIATION IN CLINICAL APPLICATIONS.

FEASIBILITY OF PREDICTING AML RESPONSE TO INDUCTION CHEMOTHERAPY

INNOVATIVE APPROACHES TO LITERACY

STTR PHASE I: INTEGRATED SOLUTION FOR LOW COST DISTRIBUTED WIND ENERGY GENERATION

TAS::89 0222::TAS NEW PHASE I SBIR; TITLE: ENERGY TRACKING SOFTWARE PLATFORM; PI: RYAN DAVIS

CARES ACT HIGHER EDUCATION EMERGENCY RELIEF FUND TO PROVIDE RELIEF TO INSTITUTIONS AFFECTED BY COVID-19

CARES ACT HIGHER EDUCATION EMERGENCY RELIEF FUND TO PROVIDE RELIEF TO STUDENTS AFFECTED BY COVID-19

THE PURPOSE OF THIS AWARD IS COUNTERING DISINFORMATION AND VIOLENT EXTREMISM. PROGRAMMING WILL AIM TO BOLSTER INVESTIGATIVE JOURNALISM AND MEDIA FREEDOM MEDIA AND DIGITAL LITERACY CYBERSECURITY

HOLISTIC OPERATIONS PLANNING SYSTEM (HOPS)

TECH CAMP ETHIOPIA IS AIMING TO GUIDE YOUTHS IN THE TRENDING TECH WORLD THROUGH HANDS ON TRAININGS AND WORKSHOPS.

SMALL, RURAL SCHOOL ACHIEVEMENT PROGRAM

SMALL, RURAL SCHOOL ACHIEVEMENT PROGRAM

SMALL, RURAL SCHOOL ACHIEVEMENT PROGRAM

SRSA APPLICATION

SRSA APPLICATION

THIS LOCALIZED AWE TOOL WILL TARGET WOMEN IN BUSINESS OPERATING AT DIFFERENT LEVELS LIKE STARTUPS INNOVATORS MANUFACTURERS RETAILERS TO PROVIDE THEM WITH AN ONLINE BUSINESS TRAINING CALLED DREAM BUILDER TO CONNECT WITH THE GLOBAL MARKET

SMALL, RURAL SCHOOL ACHIEVEMENT PROGRAM

SMALL, RURAL SCHOOL ACHIEVEMENT PROGRAM

SMALL, RURAL SCHOOL ACHIEVEMENT PROGRAM

SMALL, RURAL SCHOOL ACHIEVEMENT PROGRAM

SMALL, RURAL SCHOOL ACHIEVEMENT PROGRAM

SMALL, RURAL SCHOOL ACHIEVEMENT PROGRAM

SMALL, RURAL SCHOOL ACHIEVEMENT PROGRAM

SMALL, RURAL SCHOOL ACHIEVEMENT PROGRAM

SMALL, RURAL SCHOOL ACHIEVEMENT PROGRAM

SMALL, RURAL SCHOOL ACHIEVEMENT PROGRAM

SMALL, RURAL SCHOOL ACHIEVEMENT PROGRAM

APPLICATION FOR SMALL, RURAL SCHOOL ACHIEVEMENT PROGRAM

APPLICATION FOR SMALL, RURAL SCHOOL ACHIEVEMENT PROGRAM

SMALL, RURAL SCHOOL ACHIEVEMENT PROGRAM

SMALL, RURAL SCHOOL ACHIEVEMENT PROGRAM

ELEMENTARY AND SECONDARY SCHOOLS

ELEMENTARY AND SECONDARY SCHOOLS