Marshall University Research Corporation

WEST VIRGINIA IDEA NETWORK OF BIOMEDICAL RESEARCH EXCELLENCE (WV-INBRE)

ROBERT C BYRD ADVANCED FLEXIBLE MAUFACTURING

WEST VIRGINIA IDEAL NETWORKS OF BIOMEDICAL RESEARCH EXC*

COMMUNITY PROJECT FUNDING/CONGRESSIONALLY DIRECTED SPENDING - CONSTRUCTION - THIS CONGRESSIONALLY DIRECTED PROPOSAL CALLS FOR THE CONSTRUCTION OF THE MARSHALL COMMUNITY HEALTH INSTITUTE IN HUNTINGTON, WV. THIS APPROXIMATELY 49,000 SQUARE FOOT, NEW FACILITY WILL INCLUDE CLINICAL, EDUCATIONAL, ADMINISTRATIVE, AND RESEARCH SPACE. PRIMARY ACTIVITIES CONDUCTED WITHIN THE SITE WILL INCLUDE: AMBULATORY CLINICAL CARE SERVICES, MEDICAL EDUCATION, AND TRANSLATIONAL & CLINICAL RESEARCH ACTIVITIES. THE OVERARCHING GOAL OF THE PROJECT WILL BE TO INCREASE ACCESS TO PRIMARY CARE SERVICES IN SOUTHERN WEST VIRGINIA. ADDITIONALLY, THE FACILITY WILL SERVE AS A CATALYST TO DEVELOP INNOVATIVE SOLUTIONS TO THE GREATEST HEALTH CHALLENGES FACED BY WEST VIRGINIA; OBESITY AND DIABETES, ADDICTION AND RECOVERY, GERONTOLOGY AND HEALTHY AGING, AND RURAL HEALTH AND ACCESS TO CARE. THE COMMUNITY HEALTH INSTITUTE WILL LEAD TO THE CREATION OF CENTERS OF EXCELLENCE AIMED AT ADDRESSING THESE AREAS. THESE PHYSICAL RESOURCES WILL ALLOW MARSHALL TO DEVELOP MULTI-DISCIPLINARY AND MULTI-FACETED STRATEGIES TO IMPROVE THE HEALTH AND WELL-BEING OF PATIENTS EXPERIENCING THESE CHALLENGES. THESE ACTIVITIES WILL INCLUDE INCREASED RURAL HEALTH OUTREACH, INNOVATIVE SERVICES FOCUSED ON ADDRESSING OBESITY, NEW PROGRAMS FOCUSED ON HEALTHY AGING, AND THE EXPANSION OF HUNTINGTON’S NATIONALLY-RECOGNIZED EFFORTS TO ADDRESS ADDICTION. WHILE THE PRIMARY FOCUS OF THE FACILITY WILL BE PATIENTS IN SOUTHERN WV, THE GOAL OF THE PROGRAM IS TO DEVELOP INNOVATIVE SOLUTIONS THAT WILL SERVE AS A MODEL FOR THE REGION AND THE NATION.

APPALACHIAN CENTER FOR CELLULAR TRANSPORT IN OBESITY RELATED DISORDERS (ACCORD)

TAS::89 0222::TAS; NEW; CENTER FOR DIAGNOSTIC NANOSYSTEMS; JOHN MAHER, PI

SEE NOTICE OF AWARD, ATTACHMENT 1 - TERMS AND CONDITIONS, ATTACHMENT D, STATEMENT OF WORK, ABSTRACT.

UNIVERSITY TRANSPORTATION CENTER

ADVANCED FLEXIBLE MANUFACTURING

A HIGHLY ADVANCED STATE-OF-THE-ART DNA LABORATORY

US DEPT OF ED MENTAL HEALTH GRANT

AMERICAN APPRENTICESHIP INITIATIVE

FG-22-099 FY 2022 CONGRESSIONAL DIRECTIVE SPENDING PROJECTS - ABSTRACT THE MARSHALL UNIVERSITY CENTER OF EXCELLENCE FOR RECOVERY, HEREIN CALLED THE CENTER, STRIVES TO INCREASE WELL-BEING THROUGH THE DEVELOPMENT AND IMPLEMENTATION OF DATA-DRIVEN AND RESEARCH-BASED APPROACHES TO IMPROVE EDUCATION AND ACCESS TO EFFECTIVE PREVENTION, EARLY INTERVENTION, TREATMENT, AND RECOVERY SERVICES AND SUPPORTS. THIS DEMONSTRATION BEHAVIORAL HEALTH PROJECT WILL FOCUS ON USING CONTINUOUS QUALITY IMPROVEMENT METHODS THAT CAN BE USED TO DEVELOP AND IMPLEMENT MODELS OF CARE THAT ARE RESPONSIVE TO LOCAL COMMUNITY NEEDS AND RESOURCES IN RURAL AND UNDERSERVED AREAS OF WEST VIRGINIA WITH LOW RESOURCES, WHILE UTILIZING EVIDENCE-BASED PRACTICE PRINCIPLES. CROSS-TRAINING OF PROFESSIONALS AND NONCLINICAL PROFESSIONALS, SUCH AS PEERS, AND THE USE OF NATURAL COMMUNITY HELPERS WILL BE CORNERSTONES OF THESE MODELS. WE BELIEVE THESE PROJECTS WILL IMPROVE THE BEHAVIORAL HEALTH WORKFORCE BY ATTRACTING NEW STUDENTS INTO THE FIELD AND PROVIDING TRAINING AND EXPERIENCE FOR CURRENT PROFESSIONALS AND NON-CLINICAL PROFESSIONALS THAT WILL HELP THEM INTEGRATE BEHAVIORAL HEALTH BEST PRACTICES INTO THEIR WORK. THE CENTER WILL ACCOMPLISH THIS THROUGH FOUR MAJOR PROJECT COMPONENTS THAT INCLUDE 1) RURAL INTEGRATED CARE THROUGH COMMUNITY OUTREACH, 2) STUDENT PIPELINE INTO BEHAVIORAL HEALTH WORKFORCE, 3) APPLIED RESEARCH & EDUCATION, AND 4) PREVENTION EDUCATION PROGRAM DEVELOPMENT.

AWARD PURPOSE PURPOSE – CARRY ON RCBI'S PROVEN METHODS OF OUTREACH, TRAINING CUSTOMIZATION, AND COORDINATION WITH MANUFACTURERS AND ITS APPROACH TO ARTICULATION AGREEMENTS WITH INSTITUTIONS OF HIGHER EDUCATION. THIS WILL BE PERFORMED WITH A HEIGHTENED AWARENESS AND EMPHASIS OF TECHNOLOGICALLY ADVANCED MANUFACTURING AND MANUFACTURING IN KEY FIELDS SUCH AS AUTOMOTIVE, AEROSPACE, AND SEMICONDUCTORS. AW2 WILL CONTINUE TO ENTER INTO FORMAL AGREEMENTS WITH COMPANIES TO SPONSOR EMPLOYEE APPRENTICES AND NEGOTIATE THE NEEDS AND CONTENT OF THE APPRENTICESHIP, WORK-PROCESS SCHEDULES, AND STANDARDS. GOALS – • SERVE 910 INDIVIDUALS • INDIVIDUALS CATEGORIZED AS PARTICIPANTS IN APPRENTICESHIP PROGRAM – 400 • CREDENTIAL ATTAINMENT – 685 • EMPLOYERS TO BENEFIT FROM PROGRAM – 70 ACTIVITIES PERFORMED • RELATED TRAINING INSTRUCTION (RTI) AND ON-THE-JOB LEARNING (OJL) • SUPERVISOR TRAIN-THE-TRAINER • POSTSECONDARY EDUCATION • MICROCREDENTIALING • NEW APPRENTICEABLE OCCUPATION CREATION • TARGETING UNDERREPRESENTED DEMOGRAPHICS • MARKETING CAMPAIGN DELIVERABLES • INDIVIDUALS CATEGORIZED AS PARTICIPANTS IN APPRENTICESHIP PROGRAM – 400 • CREDENTIAL ATTAINMENT – 685 • EMPLOYERS TO BENEFIT FROM PROGRAM – 70 INTENDED BENEFICIARY ADVANCED MANUFACTURING INCUMBENT EMPLOYEES, WOMEN, HISTORICALLY UNDERREPRESENTED GROUPS, AND ECONOMICALLY DISADVANTAGED YOUTH SUBRECIPIENT ACTIVITIES SUBRECIPIENTS WILL: • REFER INDIVIDUALS TO PROGRAM ACTIVITIES • PROVIDE ESSENTIAL SKILLS TRAINING • CONNECT INDIVIDUALS TO SERVICES THAT WILL HELP PARTICIPANTS OVERCOME BARRIERS TO PARTICIPATION • CONNECT RCBI TO SIMILAR SERVICE PROVIDERS IN OTHER AREAS THROUGHOUT THE COUNTRY

FORENSIC SCIENCE CENTER DNA LABORATORY

HEALTH CARE AND OTHER FACILITIES

COMMUNITY PROJECT FUNDING/CONGRESSIONALLY DIRECTED SPENDING - CONSTRUCTION

RURAL COMMUNITIES OPIOID RESPONSE PROGRAM - MEDICATION ASSISTED TREATMENT ACCESS - MOBILE MAT PROGRAM ABSTRACT ADDRESS: MARSHALL UNIVERSITY RESEARCH CORPORATION ONE JOHN MARSHALL DRIVE HUNTINGTON, WV 25755 PROJECT DIRECTOR/PRINCIPAL INVESTIGATOR NAME: AMY SAUNDERS, MANAGING DIRECTOR CONTACT PHONE NUMBERS:304-696-4800 EMAIL ADDRESS: SAUNDE22@MARSHALL.EDU WEBSITE ADDRESS: HTTPS://WWW.MARSHALL.EDU/COEFR/ LIST ALL GRANT PROGRAM FUNDS REQUESTED IN THE APPLICATION $3,000,000 MARSHALL UNIVERSITY CENTER OF EXCELLENCE FOR RECOVERY IN COLLABORATION WITH WESTBROOK HEALTH SERVICES, IS APPLYING FOR HRSA’S RURAL COMMUNITIES OPIOID RESPONSE PROGRAM – MEDICATION ASSISTED TREATMENT ACCESS TO DEVELOP A MOBILE MAT PROGRAM TO BRING MAT AND SUPPORT SERVICES TO THREE RURAL COMMUNITIES IN WEST VIRGINIA. BY REFOCUSING A CURRENT HARM REDUCTION MOBILE UNIT AND ADDING AN ADDITIONAL MOBILE UNIT DEDICATED TO MAT AND SUPPORT SERVICES, THE WESTBROOK MOBILE MAT PROGRAM WILL BE ABLE TO CREATE NEW ACCESS POINTS IN CURRENTLY UNDERSERVED COMMUNITIES. WEST VIRGINIA HAS SUFFERED TREMENDOUSLY IN RECENT YEARS HIGH RATES OF SUBSTANCE USE DISORDERS AND LEADS THE COUNTRY IN OPIOID USE DISORDER OVERDOSE FATALITIES. EXPANDING THE REACH OF MAT AND SUPPORT SERVICES IS CRUCIAL IN SMALLER RURAL COMMUNITIES. THE GOALS OF THE WESTBROOK MOBILE MAT PROGRAM ARE: GOAL 1 - ESTABLISH NEW MAT ACCESS POINTS TO PROVIDE BOTH MEDICATIONS AND SUPPORTIVE SERVICES TO INDIVIDUALS WITH OUD AND/OR AUD IN RURAL COMMUNITIES; GOAL 2 - ENHANCE THE MAT WORKFORCE THROUGH RECRUITMENT, TRAINING, AND THE DEVELOPMENT OF PEER MENTORSHIP NETWORKS; GOAL 3 - BUILD COMMUNITY CAPACITY AND INFRASTRUCTURE TO SUPPORT MORE EFFECTIVE AND EFFICIENT MAT SERVICE PROVISION; AND, GOAL 4 - ENSURE SUSTAINABILITY OF THE NEW MAT ACCESS POINTS THROUGH IMPROVED BILLING AND CODING, AS WELL AS ENROLLMENT OF ELIGIBLE INDIVIDUALS INTO HEALTH INSURANCE. WESTBROOK IS AN EXPERIENCE LOCAL BEHAVIORAL HEALTH CENTER AND THE CENTER OF EXCELLENCE FOR RECOVERY IS ACTIVE IN IMPROVING RECOVERY OUTCOMES FOR THE REGION. THIS PARTNERSHIP WILL CREATE QUALITY MAT ACCESS AND SUPPORT IN THE HEART OF THE COMMUNITIES WHERE IT IS NEEDED THE MOST.

HEALTH CARE AND OTHER FACILITIES

GRADUATE PSYCHOLOGY EDUCATION PROGRAMS

MARSHALL RECOVERY CENTER FOR FAMILIES (MRCFF)

GENETIC AND EPIGENETIC ARCHITECTURE OF NATURAL TELOMERE LENGTH VARIATION

MECHANISMS OF CANNABINOID TOLERANCE

REGULATION OF AMINO ACID ABSORPTION IN THE MAMMALIAN SMALL INTESTINE

TRANSCRIPTION FACTORS IN CANCER

HEME OXYGENASE REGULATION OF EICOSANOID BIOSYNTHESIS

RECEPTOR NA/K-ATPASE ANTAGONISTS AS NOVEL THERAPEUTICS FOR RENAL/CARDIAC DISEASES

COMPOSITE TECHNOLOGY AND TRAINING CENTERTHROUGH THE NASA OFFICE OF SCIENCE AERONAUTICS AND EXPLO

REGULATION OF INTESTINAL NA ABSORPTION

ADVANCED NURSING EDUCATION- NURSE PRACTITIONER RESIDENCY FELLOWSHIP PROGRAM

MARSHALL UNIVERSITY FORENSIC SCIENCE CENTER (MUFSC) SEEKS TO LEVERAGE ITS EXPERTISE AND RESOURCES TO ESTABLISH - THE FORENSIC GENOMICS INSTITUTE (FGI). THE FGI WOULD BE A CENTER OF EXCELLENCE THAT FOCUSES ON THE USE OF GENETICS/GENOMICS TO IMPROVE THE QUALITY OF LIFE AND THE SAFETY OF SOCIETY. THIS INSTITUTE WOULD FUNCTION AS AN INTERDISCIPLINARY RESEARCH, TRAINING, AND SERVICE ENTITY UNDER THE AUSPICES OF MARSHALL UNIVERSITY WITH EXPERTS IN GENETICS, GENOMICS, MICROBIOLOGY, MOLECULAR BIOLOGY, BIOINFORMATICS, AND OTHER RELATED DISCIPLINES.

DISSECTING THE SHARED GENETIC MECHANISMS DRIVING FENTANYL ADDICTION, COCAINE ADDICTION, AND INCENTIVE SENSITIZATION USING THE COLLABORATIVE CROSS MOUSE PANEL - PROJECT ABSTRACT FENTANYL ADDICTION IS A HIGHLY HERITABLE DISEASE AND A CRITICAL PUBLIC HEALTH CRISIS. IN 2022, FENTANYL OVERDOSE WAS THE LEADING CAUSE OF DEATH FOR US ADULTS AGED 18 - 45. THIS STRIKING STATISTIC UNDERSCORES THE URGENT NEED TO DISCOVER AND CHARACTERIZE THE GENETIC DRIVERS OF FENTANYL ADDICTION. IN THIS REGARD, DRUG-INDUCED INCENTIVE SENSITIZATION IN BRAIN REWARD SYSTEMS IS A FUNDAMENTAL ADDICTION VECTOR. THIS HYPOTHESIS (THE INCENTIVE SENSITIZATION THEORY OF ADDICTION) POSITS THAT, OVER TIME, BRAIN REWARD SYSTEMS BECOME HYPERSENSITIZED TO THE ENVIRONMENTAL STIMULI THAT ACCOMPANY DRUG USE. THE CONSEQUENCE IS PATHOLOGICAL INCENTIVE MOTIVATION (I.E., “WANTING”) FOR THE DRUG UPON EXPOSURE TO THE DRUG-PAIRED STIMULI. ALTHOUGH FENTANYL ADDICTION AND INCENTIVE SENSITIZATION ARE HIGHLY HERITABLE IN HUMANS AND MICE, THE GENETIC ROLE OF INCENTIVE SENSITIZATION IN FENTANYL ADDICTION IS UNKNOWN. THE OVERARCHING GOAL OF THIS PROJECT IS TO IDENTIFY THE GENETIC MECHANISMS THROUGH WHICH INCENTIVE SENSITIZATION DRIVES ADDICTION-LIKE FENTANYL TAKING AND SEEKING. THIS GOAL WILL BE ACCOMPLISHED THROUGH THE INTEGRATION OF ADVANCED MOUSE RESOURCES, GOLD STANDARD BEHAVIOR AND NEUROPHYSIOLOGY ASSAYS, AND CUTTING-EDGE TRANSCRIPTOMICS. THE COLLABORATIVE CROSS (CC) RECOMBINANT INBRED MOUSE PANEL, WHICH CONTAINS 90% OF MOUSE ALLELES, WILL BE USED TO MAXIMIZE GENETIC AND PHENOTYPIC DIVERSITY. IN AIM 1, WE WILL USE INTRAVENOUS FENTANYL SELF-ADMINISTRATION TO IDENTIFY GENETIC MECHANISMS UNDERLYING CLASSICAL PHARMACOLOGICAL PHENOTYPES AND ADDICTION-LIKE BEHAVIORS IN MALE AND FEMALE MICE FROM 40 CC STRAINS. IN AIM 2, WE WILL USE PAVLOVIAN CONDITIONED APPROACH AND RNA-SEQ TO IDENTIFY GENETIC AND NUCLEUS ACCUMBENS TRANSCRIPTOMIC MECHANISMS UNDERLYING INCENTIVE SENSITIZATION IN MALE AND FEMALE MICE FROM 40 CC STRAINS. IN AIM 3, WE WILL USE SNRNA-SEQ, ISO-SEQ, ELECTROPHYSIOLOGY, AND VOLTAMMETRY TO IDENTIFY CELL-TYPE AND ISOFORM SPECIFIC ADDICTION MECHANISMS IN TWO CC STRAINS EXHIBITING EXTREME NUCLEUS ACCUMBENS-DRIVEN VULNERABILITY AND RESISTANCE, RESPECTIVELY, TO BOTH IV FENTANYL AND IV COCAINE SELF-ADMINISTRATION. USING DATA FROM THESE THREE AIMS, A COMPREHENSIVE SYSTEMS GENETICS ANALYSIS INCLUDING QTL MAPPING, EQTL MAPPING, GENETIC CORRELATION, AND DIFFERENTIAL EXPRESSION WILL BE PERFORMED TO IDENTIFY CELL-TYPE SPECIFIC AND ISOFORM SPECIFIC TRANSCRIPTOMIC SIGNATURES IN NUCLEUS ACCUMBENS THAT PREDICT BOTH PATHOLOGICAL INCENTIVE MOTIVATION AND ADDICTION-LIKE FENTANYL SELF-ADMINISTRATION. SUCCESSFUL COMPLETION OF THESE AIMS WILL PROVIDE A FOUNDATION FOR FUTURE DEEP CHARACTERIZATION OF IDENTIFIED MECHANISMS AND A LASTING COMMUNITY RESOURCE ENABLING GENETIC CORRELATIONAL ANALYSIS AMONG THE CC PANEL ACROSS PHENOTYPES, EXPERIMENTS, AND LABORATORIES. ULTIMATELY, THIS WORK WILL CONTRIBUTE TO THE DEVELOPMENT OF NOVEL, MORE EFFECTIVE ADDICTION TREATMENTS.

MARSHALL UNIVERSITY UPWARD BOUND

ELECTRONIC CIGARETTES, ADOLESCENTS, AND CHANGES IN NEUROBIOLOGY - PROJECT SUMMARY/ABSTRACT THERE IS A FUNDAMENTAL GAP IN THE UNDERSTANDING OF HOW ELECTRONIC NICOTINE DELIVERY SYSTEMS (ENDS) AL- TER THE ADOLESCENT BRAIN. ADOLESCENTS ARE A HIGH-RISK POPULATION IN REGARDS TO NICOTINE-CONTAINING PRODUCTS AS PRENATAL OR EARLY EXPOSURE TRIGGERS SIGNIFICANT CHANGES IN THE PREFRONTAL CORTEX. WITH THE GROWING POPULARITY OF ENDS AMONG AMERICAN ADOLESCENTS, THERE IS A CRITICAL NEED TO UNDERSTAND HOW ENDS DEVICES ALTER NEUROBIOL- OGY TO TRIGGER ADDICTION TO NICOTINE. THIS IS ESPECIALLY TRUE GIVEN THAT ENDS ARE UNIQUE FROM COMBUSTIBLE CIGA- RETTES GIVEN THE MULTITUDE OF FLAVORS AND DIFFERENT NICOTINE FORMULATIONS THAT ARE SPECIFIC TO ONLY ENDS E-LIQUIDS. ADDITIONALLY, POD-BASED ENDS (I.E., JUUL) CONTAIN A SIGNIFICANTLY HIGHER CONCENTRATION OF NICOTINE COMPARED TO COMBUSTIBLE CIGARETTES AND TANK-BASED ENDS. UNTIL THIS KNOWLEDGE GAP IS CLOSED, WE FACE THE RISK OF INCREASED SMOKING INITIATION, DECREASED CESSATION, AND A CUMULATIVE EFFECT OF A GROWING POPULATION OF LIFELONG SMOKERS IN AMERICA. OUR OVERALL GOAL IS TO IDENTIFY THE KEY CHANGES IN NEUROBIOLOGY, SPECIFIC TO ENDS, IN AN ADOLESCENT MOUSE MODEL SYSTEM THAT REGULATES NICOTINE REWARD AND REINFORCEMENT. TO ADDRESS THIS, WE WILL UTILIZE A NOVEL CONTINGENT NICOTINE SELF-ADMINISTRATION ASSAY SYSTEM THAT ALLOWS US TO USE THE SAME E-LIQUID TANKS AND PODS POPULAR WITH ADOLESCENT ENDS USERS IN A MOUSE MODEL SYSTEM. THIS WILL PROVIDE HIGH TRANSLATIONAL VALUE AS WE CAN DIRECTLY ASSESS HOW ENDS DIRECTLY ALTER NEUROBIOLOGY AND NEUROPHYSIOLOGY. WE HYPOTHESIZE THAT DIRECTLY LINKING SELF-ADMINISTRATION BEHAVIOR TO NACHR UPREGULATION AND CHANGES IN NEUROPHYSIOLOGY WILL IDENTIFY BRAIN REGIONS AND CELL-TYPES THAT ARE CRITICAL FOR THE INITIATION OF NICOTINE ADDICTION AND CONTINUED REINFORCEMENT. THE RATIONALE BEHIND THIS COMES FROM THE APPLICANT’S PREVIOUS SUCCESS IN CORRE- LATING NICOTINE REWARD TO NACHR UPREGULATION. WE WILL IDENTIFY ENDS-SPECIFIC CHANGES IN NEUROBIOLOGY WITH THREE SPECIFIC AIMS. FIRST, WE WILL UTILIZE E-VAPE NICOTINE SELF-ADMINISTRATION ASSAYS IN MICE TO EXAMINE INITIATION AND NICOTINE REINFORCEMENT OF ENDS TO EXAMINE THE IMPACT OF NICOTINE DOSE, FORMULATION, AND FLAVORS ON VAP- ING-RELATED BEHAVIOR. SECOND, WE WILL USE THE BRAINS FROM THE FIRST AIM TO EXAMINE NACHR UPREGULATION AND PROVIDE A DIRECT LINK BETWEEN SELF-ADMINISTRATION BEHAVIOR AND NACHR UPREGULATION. THIRD, WE WILL EXAMINE CHANGES IN NEUROPHYSIOLOGY VIA ELECTROPHYSIOLOGY AND FAST-SCAN CYCLIC VOLTAMMETRY. THIS APPROACH IS INNOVATIVE, IN THE APPLICANT'S OPINION, BECAUSE IT ESTABLISHES A DIRECT CORRELATION BE- TWEEN VAPING-RELATED SELF-ADMINISTRATION AND NACHR UPREGULATION AS WELL AS CHANGES IN NEUROPHYSIOLOGY IN AN IN VIVO MODEL AND UTILIZES THE EXACT SAME ENDS AND E-LIQUIDS POPULAR WITH HUMAN ADOLESCENT VAPERS. THIS IS COMPLEMENTED BY THE USE OF A NOVEL MOUSE EXPRESSING A4-MCHERRY AND A6-GFP NACHR SUBUNITS THAT ALLOW ANALYSIS OF UPREGULATION WITHOUT THE USE OF ANTIBODIES. THE PROPOSED RESEARCH IS SIGNIFICANT, BECAUSE IT WILL DRAMATICALLY INCREASE OUR KNOWLEDGE OF HOW ENDS CONTRIBUTE TO ADDICTIVE BEHAVIOR. THIS WOULD CONTRIBUTE SIG- NIFICANTLY TO SEVERAL OF THE PRIORITIES AND INTERESTS OF NIDA.

THIS PROPOSAL BEGINS AN EFFORT THAT HOPES TO BUILD CAPACITY AT MARSHALL UNIVERSITY TO ADDRESS THE NEEDED TRAINING OF STATE AND LOCAL LAW ENFORCEMENT OFFICIALS IN FORENSIC SCIENCE TECHNIQUES – PARTICULARLY IN THE TECHNICAL AREAS OF CYBER FORENSICS TOOLS AND PROCESSES AND IN FORENSIC GENETIC GENEALOGY (FGG) TECHNOLOGIES. THE PRINCIPAL INVESTIGATORS (PIS) FOR THIS INITIATIVE ARE DR. DAVID DAMPIER, DEAN OF THE COLLEGE OF ENGINEERING AND COMPUTER SCIENCES AND DIRECTOR OF THE INSTITUTE FOR CYBER SECURITY AND MR. JASON CHUTE, DIRECTOR OF THE MARSHALL UNIVERSITY FORENSIC SCIENCE CENTER. THE TOTAL COST FOR THIS PROPOSED EFFORT IS $1,750,000.00 DURING THE PERIOD OCTOBER 1, 2022 – MARCH 31, 2024. COLLABORATORS INCLUDE THE STATE OF WEST VIRGINIA STATE POLICE FORENSICS LABORATORY AND THE MOUNTWEST COMMUNITY AND TECHNICAL COLLEGE (MCTC) OF HUNTINGTON, WEST VIRGINIA. LONG-TERM GOALS OF THIS INITIATIVE INCLUDE SUPPORT FOR THE STATE’S FORENSIC SCIENCE LABORATORIES FOR BOTH CYBER FORENSICS AND FORENSIC GENETIC GENEALOGY IN HUNTINGTON, WV AND TRAINING STATE AND LOCAL LAW ENFORCEMENT OFFICIALS ON A REGIONAL BASIS IN MODERN TACTICAL FORENSIC TECHNIQUES NECESSARY FOR COMBATING THE GROWING INCIDENCE OF BOTH COMPUTER-BASED CRIME, AS WELL AS ON DNA TECHNOLOGIES TO PROVIDE INVESTIGATIVE LEADS IN THE EFFORT TO HELP SOLVE CRIMINAL CASES. DELIVERABLES INCLUDE NO COST TECHNICAL SHORT COURSES FOR STATE AND LOCAL LAW ENFORCEMENT OFFICIALS AND BUILDING AND RENEWING LOCAL POLICE FORENSIC LABORATORIES.

STUDENT SUPPORT SERVICES TRIO PROGRAM

UPWARD BOUND

UPWARD BOUND PROVIDES FUNDAMENTAL SUPPORT TO LOW-INCOME AND FIRST-GENERATION PARTICIPANTS IN THEIR PREPARATION FOR COLLEGE ENTRANCE.

EDUCATIONAL TALENT SEARCH PROGRAM WHICH WILL SERVE 600 STUDENTS IN MASON AND WAYNE COUNTY MIDDLE AND HIGH SCHOOLS.

EXOSOMES FROM MIR-PRIMED ENDOTHELIAL PROGENITOR CELLS FOR TREATING ISCHEMIC STROKE

NICOTINE AND ALCOHOLIC LIVER DISEASE

TALENT SEARCH PROGRAM

EMPOWERING APPALACHIA TALENT SEARCH

STUDENT SUPPORT SERVICES PROGRAM

WVPRC DRUG ABUSE PREVENTION

COMMUNITY REVITALIZATION

ESTABLISHING A FORENSIC GENETIC GENEALOGY AND MITOCHONDRIAL DNA TESTING AND RESEARCH UNIT AT THE MARSHALL UNIVERSITY FORENSIC SCIENCE CENTER MARSHALL UNIVERSITY FORENSIC SCIENCE CENTER (MUFSC) PROPOSES TO IMPLEMENT A FORENSIC GENETIC GENEALOGY AND MITOCHONDRIAL DNA TESTING AND RESEARCH UNIT. ADVANCES IN DNA SEQUENCING TECHNOLOGY (I.E., MPS, OR MASSIVELY PARALLEL SEQUENCING) HAVE MADE FGG AND FORENSIC MITOCHONDRIAL DNA (MTDNA) ANALYSIS A MORE COST-EFFECTIVE TOOL, TRANSFORMING LAW ENFORCEMENT INVESTIGATIONS BY HELPING TO SOLVE PREVIOUSLY UNSOLVABLE CASES. HOWEVER, AS WITH ANY NEW TECHNOLOGY INTRODUCED TO THE FIELD, SUCH AS MPS, THERE IS A NEED FOR RESEARCH, EDUCATION AND TRAINING, AND TESTING SERVICES. AS DEMONSTRATED BY SIMILAR SUCCESSFUL PROJECTS IN THE PAST, WITH THE ADDITION OF MPS AND MTDNA ANALYSIS, MUFSC WILL ADDRESS THESE NEEDS BY BUILDING FROM OUR CURRENT FOUNDATION OF TECHNOLOGY AND EXPERTS, SPECIFICALLY FOCUSING ON PROVIDING RESEARCH AND SERVICES TO THE CRIMINAL JUSTICE AND FORENSIC COMMUNITIES. SPECIFIC PROJECT ACTIVITIES WILL INCLUDE ACQUIRING THE APPROPRIATE INSTRUMENTATION, MAKING NECESSARY LABORATORY CHANGES, DESIGNING AND EXECUTING A VALIDATION PLAN, CREATING APPROPRIATE STANDARD OPERATING PROCEDURES, AND APPLYING FOR ACCREDITATION SCOPE EXPANSION. THE EXPECTED OUTCOMES FROM THIS PROJECT INCLUDE PROVIDING RESEARCH, EDUCATION, AND SERVICES IN THE AREA OF FORENSIC MTDNA ANALYSIS AND DNA SEQUENCING FOR FGG INVESTIGATIONS. ONCE DEVELOPED, IT IS ANTICIPATED THAT THIS RESOURCE WILL BE A PART OF THE SUSTAINED ACTIVITIES MUFSC HAS PROVIDED TO THE FORENSIC COMMUNITY FOR THE PAST 20 YEARS.

CONTINUATION OF THE WV CYBER SECURITY CENTER FOR CRITICAL INFRASTRUCTURE

ESTABLISHING A CYBER SECURITY CENTER FOR CRITICAL INFRASTRUCTURE

THE WV COLLEGIATE STRATEGIC PREVENTION FRAMEWORK PARTNERSHIP'S FOR SUCCESS INITIATIVE

RURAL HEALTH OUTREACH SPECIAL INITIATIVE

INDEPENDENT INITIATIVE

STUDENT SUPPORT SERVICES PROGRAM

GENETICS OF DIET-INDUCED OBESITY IN A NEW MOUSE MODEL

EDUCATIONAL OPPORTUNITY CENTER PROGRAM WHICH WILL SERVE 1000 PARTICIPANTS IN CABELL, LINCOLN, MASON, AND WAYNE COUNTIES

THE WELLNESS PROJECT - THE MARSHALL UNIVERSITY RESEARCH CORPORATION’S GBHI INITIATIVE (THE WELLNESS PROJECT) IMPROVES ACCESS TO AND DELIVERY OF COORDINATED, COMPREHENSIVE SERVICES TO REDUCE SUBSTANCE USE AND IMPROVE HOUSING STABILITY IN CABELL & WAYNE COUNTIES IN WEST VIRGINIA, WHOSE POPULATION SUFFERS FROM HIGH OPIOID OVERDOSE DEATH RATES & POOR SOCIAL DETERMINANTS OF HEALTH. THE PROJECT WILL SERVE 250 CLIENTS (50/YEAR). PROJECT GOALS (INTERVENTIONS/STRATEGIES) INCLUDE: (1) IMPROVE ACCESS TO AND DELIVERY OF COORDINATED, COMPREHENSIVE SERVICES TO REDUCE SUBSTANCE USE AND IMPROVE HOUSING STABILITY FOR THE TARGET POPULATION BY (A) HIRING A PROJECT DIRECTOR TO BUILD AN INTEGRATED CONTINUUM OF CARE FOR THE UNHOUSED; (B) COMPLETING A COMMUNITY NEEDS ASSESSMENT TO IDENTIFY EXISTING RESOURCES/SERVICE GAPS; (C) PARTNERING WITH THE WV BEHAVIORAL HEALTH TRAINING CENTER TO ENHANCE WORKFORCE DEVELOPMENT FOR THE CONTINUUM OF CARE; (D) PROVIDING ALL PEOPLE ENGAGED WITH SERVICES AT HUNTINGTON CITY MISSION & HARMONY HOUSE W/ SCREENING BRIEF INTERVENTION & REFERRAL TO TREATMENT; (E) PARTNERING WITH AREA BEHAVIORAL HEALTH/SUD PROVIDERS TO ENSURE PROVISION OF CULTURALLY COMPETENT SAME-DAY SUD/COD SERVICES TO CLIENTS; (F) HIRING A CLINICAL DIRECTOR TO OVERSEE/DIRECT ALL INTEGRATED HEALTHCARE SERVICES DELIVERED THROUGH THE WELLNESS PROJECT; (G) PARTNERING WITH AREA MAT PROVIDERS TO ENSURE PROVISION OF EXPEDITED CULTURALLY COMPETENT SERVICES; (H) CREATING PARTNERSHIPS THAT ALLOW THE CLINICAL DIRECTOR TO FACILITATE EXPEDITED CULTURALLY COMPETENT RECOVERY SUPPORT SERVICES; (I) HIRING PEER RECOVERY SUPPORT SPECIALISTS (PRSS) TO PROVIDE DIRECT CULTURALLY COMPETENT SERVICES; (J) PARTNERING WITH HARM REDUCTION PROVIDERS TO ENSURE PROVISION OF CULTURALLY COMPETENT SAME-DAY SERVICES; (K) PARTNERING WITH THE COMMUNITY & CITY REPRESENTATIVES TO DEVELOP A CAMPAIGN TO REDUCE STIGMA TOWARD THE UNHOUSED & (L) HIRING A THERAPIST TO ENSURE PROVISION OF CULTURALLY COMPETENT SAME-DAY SUD/COD SERVICES. (2) INCREASE TARGET POPULATION ENGAGEMENT & CONNECTION TO BEHAVIORAL HEALTH, HARM REDUCTION, CASE MANAGEMENT & RECOVERY SUPPORT SERVICES BY (A) PARTNERING WITH LOCAL STREET OUTREACH PROGRAMS TO ENGAGE CLIENTS IN THE INTEGRATED CONTINUUM OF CARE; (B) IDENTIFYING COMMUNITY AGENCIES/STAKEHOLDERS WHO ALLY WITH DISPARITY GROUP COMMUNITIES TO DEVELOP CULTURALLY COMPETENT OUTREACH & SERVICES & (C) EXPANDING MEDICAL DIRECTOR TIME TO ENGAGE THE FOCUS POPULATION IN BEHAVIORAL HEALTH/SUD SERVICES. (3) INCREASE CASE MANAGEMENT CAPACITY TO SUPPORT TARGET POPULATION STABILITY ACROSS SERVICES, HOUSING TRANSITIONS & PERMANENT HOUSING BY (A) HIRING NAVIGATORS TO HELP CLIENTS NAVIGATE THE CONTINUUM OF CARE USING CRITICAL TIME INTERVENTION; (B) SERVING 50 CLIENTS/YEAR; (C) ENGAGING CLIENTS IN REDUCING HIV/AIDS RISK BEHAVIORS BY FACILITATING SCREENING/CONNECTING CLIENTS WITH APPROPRIATE SERVICES; (D) MAINTAINING RELATIONSHIPS WITH THE PUBLIC HOUSING AUTHORITY (PHA) AND PRIVATE LANDLORDS; (E) LIAISING WITH LOCAL LANDLORDS AND THE PHA TO ADDRESS LANDLORD CONCERNS ABOUT PROPERTY DAMAGE AND ADVOCATE FOR CLIENTS; (F) CONDUCTING HOME VISITS FOR ALL CLIENTS TO HELP CLIENTS MAINTAIN PERMANENT HOUSING & (G) WORKING WITH CLIENTS TO DEVELOP WORKFORCE SKILLS TO SUPPORT MAINTAINING SUCCESSFUL PERMANENT HOUSING. (4) IMPROVE SUBSTANCE USE AND MENTAL HEALTH OUTCOMES FOR UNHOUSED INDIVIDUALS WITH SUD/COD BY (A) EMPOWERING 50% OF TREATMENT COMPLIANT CLIENTS TO HAVE A REDUCTION IN SUBSTANCE USE AT 6-MONTH FOLLOW-UP; (B) EMPOWERING CLIENTS TO HAVE STATISTICALLY SIGNIFICANT IMPROVEMENTS IN GPRA MENTAL HEALTH OUTCOMES AT 6-MONTH FOLLOW-UP; (C) EMPOWERING CLIENTS TO REMAIN IN SERVICES FOR AT LEAST 6-MONTHS & (D) MONITORING DISPARITY GROUP OUTCOMES TO ENSURE EQUAL ACCESS/SERVICE/OUTCOMES/RETENTION. (5) SUSTAIN THE CONTINUUM OF CARE FOR THE UNHOUSED BEYOND GRANT FUNDING BY (A) LEADING THE STEERING COMMITTEE IN QUARTERLY MEETINGS & (B) CREATING A SUSTAINABILITY PLAN TO BE UPDATED ANNUALLY.

TALENT SEARCH PROGRAM

ATP1A1-DEPENDENT REGULATION OF SODIUM HANDLING BY THE RENAL PROXIMAL TUBULE: MECHANISM AND IMPLICATIONS IN SALT-SENSITIVITY - ATP1A1 IS THE ONLY NA/K-ATPASE (NKA) ISOFORM EXPRESSED IN THE KIDNEY. AS STATED IN PHYSIOLOGY TEXTBOOKS, NKA IS THE ENZYMATIC MACHINERY THAT POWERS ENERGY STORAGE IN THE FORM OF A TRANSMEMBRANE NA+ GRADIENT, WHICH IS ESSENTIAL FOR RENAL SALT HANDLING AND THE CONTROL OF BLOOD PRESSURE. IN THE RENAL PROXIMAL TUBULE (RPT), ACTIVATION OF NKA-MEDIATED CLASSIC ION TRANSPORT FUNCTION DECREASES NATRIURESIS THROUGH ACTIVATION OF BOTH BASOLATERAL (NKA) AND APICAL (NHE3) NA+ REABSORPTION. IN CONTRAST, ACTIVATION OF THE MORE RECENTLY DISCOVERED NKA SIGNALING FUNCTION TRIGGERS A CELLULAR REDISTRIBUTION OF BOTH NKA AND NHE3 IN RPT CELLS, WHICH DECREASES NA+ UPTAKE. HENCE, RPT NKA SIMULTANEOUSLY SERVES TWO OPPOSING ROLES IN NA+ HANDLING: ANTI-NATRIURETIC THROUGH ITS CLASSIC ATPASE-DRIVEN ION TRANSPORT FUNCTION, AND NATRIURETIC THROUGH ITS MORE RECENTLY RECOGNIZED RECEPTOR/SIGNALING FUNCTION. TO DATE, THE RELATIVE CONTRIBUTIONS OF THESE TWO NKA FUNCTIONS TO THE NET RPT NA+ HANDLING IN VIVO IS A FUNDAMENTALLY AND THERAPEUTICALLY ESSENTIAL QUESTION THAT HAS BEEN VIRTUALLY IMPOSSIBLE TO ANSWER. NKA SIGNALING, WHICH IS BOTH DISTINCT AND INDEPENDENT FROM NKA CLASSIC ENZYMATIC ION-TRANSPORTING FUNCTION, WAS FIRST BROUGHT TO THE ATTENTION OF THE SCIENTIFIC COMMUNITY BY THE WORK OF DR. ZIJIAN XIE IN OUABAIN-TREATED CARDIAC MYOCYTES AND RENAL EPITHELIAL CELLS. MECHANISTICALLY, BINDING OF NKA SPECIFIC LIGANDS SUCH AS THE CARDIOTONIC STEROID (CTS) OUABAIN ACTIVATES SRC, RESULTING IN THE ACTIVATION OF MULTIPLE PROTEIN/LIPID KINASES AND THE GENERATION OF INTRACELLULAR SECOND MESSENGERS. NUMEROUS GROUPS AROUND THE WORLD HAVE EXPANDED THE CONCEPT OF NON- ENZYMATIC SIGNALING FUNCTION OF NKA, WHILE WE HAVE FOCUSED ON THE MECHANISM BY WHICH NKA IS ENGAGED IN DIRECT INTERACTION WITH SEVERAL SIGNALING AND SCAFFOLDING PROTEINS INCLUDING SRC. THIS HAS ALLOWED US TO DEVELOP ATP1A1 MUTANTS WITH INTACT ENZYMATIC FUNCTION BUT DEFECTIVE ABILITY OF INTERACTION WITH SIGNALING PARTNERS. CRITICALLY, WE HAVE DEVELOPED A HYPOMORPHIC MOUSE (RPTA1-/-) WITH A RPT-SPECIFIC REDUCTION OF 70% OF NKA A1. THE HYPER-REABSORPTIVE RENAL PHENOTYPE OF THIS MOUSE SUGGESTS THAT NKA SIGNALING IS NOT ONLY PHYSIOLOGICALLY RELEVANT, BUT ALSO FUNCTIONALLY PREVALENT IN THE REGULATION OF RPT NA+ HANDLING. WE HAVE ESTABLISHED FEASIBILITY OF RPT-SPECIFIC RESCUE OF THE HYPOMORPHIC RPTA1-/- MOUSE WITH EITHER WILD-TYPE OR SRC-BINDING NULL MUTANT FORMS OF NKA, AND PROPOSE TO USE THOSE NEW TOOLS TO TEST THE CENTRAL HYPOTHESIS THAT NKA A1 (ATP1A1) EXERTS A TONIC INHIBITION OF APICAL NHE3 AND BASOLATERAL NA+ TRANSPORTERS IN THE RPT. WE FURTHER SURMISE THAT THIS REGULATORY MECHANISM HAS A PREVALENT REGULATORY ROLE IN RPT NA+ HANDLING (AIM 1), DEPENDS ON NKA A1/SRC INTERACTION (AIM 2), AND ENABLES NKA A1 LIGANDS SUCH AS CTS TO MODULATE RPT NA+ REABSORPTION (AIM 3). SUCCESSFUL COMPLETION OF THE PROPOSED INVESTIGATION SHALL REVEAL A HITHERTO UNRECOGNIZED REGULATORY MECHANISM OF SALT HANDLING BY RPT NKA A1, THE MOLECULAR BASIS OF THIS REGULATION, AN INTEGRATED COMPENSATORY TRANSPORT NETWORK, AND THEIR IMPACT ON RENAL PHYSIOLOGY AND THE DEVELOPMENT OF SALT SENSITIVITY.

UPWARD BOUND PROGRAM

CONGRESSIONALLY-MANDATED HEALTH INFORMATION TECHNOLOGY GRANTS

APPALACHIAN HATCHERY

IMPLEMENTING LIFECYCLE CHARACTERIZATION OF EMBEDDED DAM GATE ANCHORAGE USING NON-DESTRUCTIVE TESTING AND STRUCTURAL HEALTH MONITORING

GRADUATE PSYCHOLOGY EDUCATION PROGRAMS

CAPSAICIN AND SMALL CELL LUNG CANCER THERAPY

PRIMARY CARE TRAINING AND ENHANCEMENT: PHYSICIAN ASSISTANT RURAL TRAINING PROGRAM

PROJECT: PREPARED TO CARE""

EDUCATIONAL OPPORTUNITY CENTERS PROGRAM

STRATEGIES: SCI-TALKS (SUPPORTING COMMUNITY INITIATIVES FOR TEACHING, LEARNING, AND KNOWING SCIENCE)

EDUCATIONAL OPPORTUNITY CENTERS PROGRAM

TALENT SEARCH PROGRAM

TALENT SEARCH PROGRAM

TRIO - STUDENT SUPPORT SERVICES - STUDENT SUPPORT SERVICES PROGRAM

COMMUNITY CAPACITY

PRIMARY CARE TRAINING AND ENHANCEMENT

MARSHALL UNIVERSITY EXPLORATORY CENTER OF EXCELLENCE FOR STRENGTHENING AND EXTENDING RESOURCE CAPACITY TO PREPARE LOW INCOME AND MINORITY STUDENTS FOR ACADEMIC SUCCESS

THIS EDA INVESTMENT WILL ASSIST WITH PERSONNEL, EQUIPMENT, AND CONTRACTUAL EXPENSES ASSOCIATED WITH EXPANDING AND UPDATING THE MARSHALL ADVANCED MANUFACTURING CENTER (MAMC) IN SOUTH CHARLESTON, WEST VIRGINIA. THE PROJECT WILL CREATE 46 NEW JOBS, ASSIST WITH THE RETENTION OF 30 JOBS AND GENERATE $31 MILLION IN PRIVATE INVESTMENT.

DETERMINING ENVIRONMENTAL TRIGGERS OF HARMFUL ALGAL BLOOMS AND TOXIN PRODUCTION FOR THE PURPOSES OF HAB PREDICTION, DETECTION, AND MANAGEMENT.

MARSHALL UNIVERSITY RESEARCH CORPORATION - FY23 CONGRESSIONAL COMMUNITY PROJECT FUNDING

FY 22 CONGRESSIONAL COMMUNITY PROJECT FUNDING CONGRESSIONAL EARMARK MARSHALL UNIVERSITY RESEARCH CORPORATION

EXPANDING THE WV CYBER SECURITY CENTER FOR CRITICAL INFRASTRUCTURE

IMPROVING THE WELL-BEING OF FAMILIES IN WEST VIRGINIA - MARSHALL UNIVERSITY'S CENTER OF EXCELLENCE FOR RECOVERY (CENTER OF EXCELLENCE) WILL WORK WITH PRESTERA HEALTH SERVICES (PRESTERA), THE LARGEST COMPREHENSIVE BEHAVIORAL HEALTH SERVICES PROVIDER IN WEST VIRGINIA, TO DEVELOP AND IMPLEMENT AN INTENSIVE CARE COORDINATION MODEL FOR INDIVIDUALS AND THEIR CHILDREN IMPACTED BY SUD. THIS MODEL WILL INTEGRATE A WRAPAROUND PROCESS, USED IN THE PAST, AND THE WELLNESS RECOVERY ACTION PLAN (WRAP) IN CABELL, WAYNE, LINCOLN, KANAWHA AND BOONE COUNTIES. THE CENTER OF EXCELLENCE AND PRESTERA WILL DEVELOP A MANUAL WITH UNIVERSAL GUIDELINES FOR STAFFING, TRAINING, SERVICE PROCESS, AND PROCEDURES TO CARE FOR 25 ADULTS AND 25 CHILDREN IN RURAL/SUBURBAN AREAS. THE GOAL IS FOR THIS NEW MODEL TO BE REPLICATED THROUGHOUT WV TO ASSIST CHILDREN AND FAMILIES.

SUPPORTING WV TRANSITIONAL AGED YOUTH

ADVANCED NURSING EDUCATION - SEXUAL ASSAULT NURSE EXAMINERS PROGRAM - EXPANDING SANE CARE IN WEST VIRGINIA THE OVERALL PURPOSE OF THE MARSHALL UNIVERSITY (MU) SEXUAL ASSAULT NURSE EXAMINER (SANE) INITIATIVE, MU SANE, IS TO INCREASE THE SUPPLY, DISTRIBUTION, AND QUALITY OF THE SANE WORKFORCE IN WEST VIRGINIA (WV). BY INCREASING THIS WORKFORCE, THIS INITIATIVE AIMS TO PROVIDE ACCESS TO MENTAL AND PHYSICAL CARE FOR SURVIVORS OF SEXUAL ASSAULT AND DOMESTIC VIOLENCE IN THE STATE. THE POPULATION OF WV IS A RURAL, ECONOMICALLY DISADVANTAGED STATE, WITH APPROXIMATELY 1.8 MILLION PEOPLE; 93% OF THE POPULATION IS CAUCASIAN WITH 15.5% OF THOSE OVER THE AGE OF 18 LIVING IN POVERTY. WV IS OVERWHELMINGLY AFFECTED BY MANY FACTORS THAT CONTRIBUTE TO HEALTH DISPARITIES, INCLUDING HIGH RATES OF POVERTY, LACK OF ECONOMIC OPPORTUNITIES, LOW LEVELS OF EDUCATIONAL ATTAINMENT, AND GEOGRAPHIC CHALLENGES. GENERATIONS OF WV RESIDENTS HAVE STRUGGLED WITH HIGH RATES OF SUBSTANCE USE AND MENTAL HEALTH DISORDERS, TRAUMA, VIOLENCE AND SEXUAL ASSAULT AS WELL AS CHRONIC DISEASES DUE TO MANY NEGATIVE HEALTH DISPARITIES, INCLUDING POOR ACCESS TO HEALTH AND MENTAL HEALTH CARE. MOST OF WV’S COUNTIES QUALIFY AS HEALTH AND MENTAL HEALTH PROFESSIONAL SHORTAGE AREAS. THE COMBINATION OF NEED AND THE STARK LACK OF RESOURCES REPRESENT A LARGE CRISIS IN WV. HEALTH PRACTITIONERS OF ALL TYPES, ESPECIALLY SANE TRAINED NURSES AND CERTIFIED SANE NURSES, ARE IN SHORT SUPPLY IN THE STATE, PARTICULARLY IN RURAL AREAS. CURRENTLY, THERE ARE LESS THAN TEN CERTIFIED SANE NURSES WORKING IN WV. THE CURRENT STATE OF AVAILABLE SANE NURSES IS IN AN EMERGENCY STATE FOR SEXUAL ASSAULT VICTIMS IN WV; WITH NEW LAWS COMING TO BARE ON A HEALTH CARE SYSTEM THAT CANNOT SUPPORT 24/7 SANE NURSES IN WV HOSPITALS. WE WILL ENDEAVOR TO INCREASE THE NUMBER OF TRAINED SANES IN WV BY CREATING A MICRO-CREDENTIAL FOR TRAINING SANES AT MARSHALL UNIVERSITY, INVOLVING 4 LEVELS OF TRAINING - LEVEL 1: DIDACTIC LEARNING OF SANE CONTENT, 40 HOURS ONLINE CONTENT THAT IS WV SPECIFIC. LEVEL 2: BUIL DING A STATIONERY LAB AND MOBILE LAB, FOR PELVIC SKILL TRAINING: SPECULUM INSERTION, SPECIMEN COLLECTIONS, AND TRAUMA INFORMED CARE PRACTICE LEVEL 3: PRECEPTORSHIP/MENTORSHIP PAIRING OF QUALIFIED PRECEPTORS WITH AN MU SANE STUDENT, AS WELL AS SUPPORTING THEIR COMPLETION OF THE PROGRAM. LEVEL 4: CERTIFICATION TESTING AND COMPLETION, THE MU SANE INITIATIVE WILL PROVIDE SUPPORT AND FUNDING FOR THE CERTIFICATION EXAM, TRAVEL FOR TRAINEES, AND/OR PAID TIME OFF TO TAKE THE EXAM. MU SANE WILL PROVIDE AN EXAM PREPARATION CLASS FOR TRAINEES BEFORE TAKING THE CERTIFICATION EXAM. THE MU SANE PROJECT IS BUILT AROUND THE FOUR HRSA GOALS, WHICH DIRECTLY ALIGNS WITH THE CRITICAL NEEDS OF WV. EXPECTED OUTCOMES INCLUDE: 1. INCREASE THE NUMBER OF TRAINED QUALIFIED SANE NURSES BY 20 EACH YEAR (60 OVER THE 3 YEARS, COURSE OF GRANT) AND CERTIFIED SANE NURSES IN WV. (2 NURSES OBTAINING SANE CERTIFICATION IN YEAR 1, 3 IN YEAR 2, AND 5 IN YEAR 3 FOR A TOTAL 10 TOTAL). 2. INCREASE THE NUMBER OF SANE TRAINING COURSES OFFERED EACH YEAR. MARSHALL UNIVERSITY WILL OFFER 4 PER YEAR. (2 PER SEMESTER, FOR THREE YEARS) 3. EXPAND ACCESS TO SEXUAL ASSAULT FORENSIC EXAMINATIONS, ESPECIALLY IN RURAL AND UNDERSERVED AREAS. WE WILL DEVELOP MOUS WITH 4 RURAL HOSPITALS, TO INCLUDE NURSES INTERESTED IN BECOMING SANE TRAINED. WE WILL BE SETTING UP PERMANENT AND MOBILE LABORATORY EXPERIENCES. ESTABLISH A PRECEPTOR NETWORK TO HELP THEM COMPLETE THEIR TRAINING AND TAKE THE CERTIFICATION EXAM. 4. FOSTER AN ENVIRONMENT THAT SUPPORTS SANE TRAINING, PRACTICE AND RETENTION. WE WILL CREATE AN ADVISORY COUNCIL OF STAKEHOLDERS (OB/GYN PHYSICIANS, APRN OB/GYN IN PRACTICE, COMMUNITY MEMBERS) THAT CAN PROVIDE SUPPORT AND SUSTAIN THE PRACTICE OF SANE IN WV.

WORKFORCE TRAINING

SCHOLARSHIPS AND A PROJECT-BASED WORK STUDIO TO SUPPORT UNDERGRADUATE STUDENT GRADUATION AND ENTRY INTO COMPUTER SCIENCE, ENGINEERING, AND SAFETY TECHNOLOGY CAREERS

AMT TRAINING SCHOOL

DESCRIPTION:THIS BIPARTISAN INFRASTRUCTURE LAW (BIL) (ALSO KNOWN AS THE INFRASTRUCTURE INVESTMENT AND JOBS ACT (IIJA)) FUNDED COOPERATIVE AGREEMENT PROVIDES FUNDING FOR MARSHALL UNIVERSITY RESEARCH CORPORATION TO CONDUCT REMEDIATION ACTIVITIES AS AUTHORIZED BY CERLCA 104(K)(3) IN HUNTINGTON, WEST VIRGINIA.ACTIVITIES:SPECIFICALLY, THIS AGREEMENT WILL PROVIDE FUNDING TO THE RECIPIENT TO CLEAN UP A BROWNFIELD SITE. ADDITIONALLY, THE RECIPIENT WILL COMPETITIVELY PROCURE (AS NEEDED) AND DIRECT A QUALIFIED ENVIRONMENTAL PROFESSIONAL TO CONDUCT ENVIRONMENTAL SITE ACTIVITIES, WILL CREATE A COMMUNITY INVOLVEMENT PLAN AND ADMINISTRATIVE RECORD FOR THE SITE, AND WILL REPORT ON INTERIM PROGRESS AND FINAL ACCOMPLISHMENTS BY COMPLETING AND SUBMITTING RELEVANT PORTIONS OF THE PROPERTY PROFILE FORM USING EPA'S ASSESSMENT, CLEANUP AND REDEVELOPMENT EXCHANGE SYSTEM (ACRES).SUBRECIPIENT:NO SUBAWARDS ARE INCLUDED IN THIS ASSISTANCE AGREEMENT.OUTCOMES:FURTHER, THE RECIPIENT WILL REMEDIATE 1 BROWNFIELD SITE(S) AND ANTICIPATES HOLDING 8 COMMUNITY MEETINGS, FINALIZING 1 ANALYSIS OF BROWNFIELD CLEANUP ALTERNATIVES, AND SUBMITTING 8 QUARTERLY REPORTS. WORK CONDUCTED UNDER THIS AGREEMENT WILL BENEFIT THE RESIDENTS, BUSINESS OWNERS, AND STAKEHOLDERS IN AND NEAR HUNTINGTON, WEST VIRGINIA.

WEST VIRGINIA PREVENTION RESOURCE CENTER

MARSHALL UNIVERSITY SBIRT

MRI-R2: ACQUISITION OF A CONFOCAL/MULTIPHOTON MICROSCOPE TO ADVANCE CELLULAR AND PHYSIOLOGICAL RESEARCH AT MARSHALL UNIVERSITY

TALENT SEARCH PROGRAM

COMMUNITY PROJECT GRANTS CONGRESSIONALLY DELEGATED

TALENT SEARCH PROGRAM

OMEGA-3 FAT TO REDUCE RISK FOR BREAST CANCER

THYMIDINE PHOSPHORYLASE: A NOVEL TARGET OF ANTIPLATELET THERAPY

YSTR ANALYSIS TRAINING IN SUPPORT OF STATE AND LOCAL CRIME LABORATORIES

EDUCATIONAL OPPORTUNITY CENTERS PROGRAM

TECHNICAL ASSISTANCE, TRAINING, AND EVALUATION FOR THE LOCAL CRIMINAL JUSTICE COMMUNITY ENGAGED IN DIGITAL FORENSIC ACTIVITIES

TO SUPPORT A TRAINING INITIATIVE FOR PERSONNEL IN THE AREA OF COMPUTER CRIME INVESTIGATIONS

ADVANCE INSTITUTIONAL TRANSFORMATION AWARD: ADVANCING WOMEN IN SCIENCE, MATH AND ENGINEERING AT MARSHALL

CAREER: UNTANGLING THE EFFECTS OF MULTIPLE ENVIRONMENTAL DRIVERS ON DRYLAND PLANT COMMUNITIES TO INFORM LAND MANAGEMENT DECISIONS -THIS PROJECT WILL TEST HOW FIRE, INVASIVE SPECIES, AND ENVIRONMENTAL CHANGE AFFECT BIODIVERSITY IN RANGELANDS. MUCH OF THE WESTERN U.S. IS HOME TO BIG SAGEBRUSH. THIS ECOSYSTEM SUPPORTS MANY WILD SPECIES AND LIVESTOCK GRAZING. HOWEVER, BIG SAGEBRUSH COMMUNITIES ARE DECLINING DUE TO STRESS THAT CAUSES LOSS OF BIODIVERSITY. BECAUSE MOST ECOSYSTEMS EXPERIENCE MULTIPLE STRESSORS AT ONCE, IT IS IMPORTANT TO LEARN HOW THEY WORK TOGETHER TO CAUSE BIODIVERSITY LOSS. TO STUDY THIS, THIS PROJECT WILL TEST WHICH COMBINATIONS OF THREATS ARE MOST LIKELY TO REDUCE THE ABILITY OF THESE SYSTEMS TO RECOVER AND CAUSE THE LOSS OF BIG SAGEBRUSH HABITATS. THE PROJECT WILL ALSO INVESTIGATE IF THERE ARE WAYS TO MANAGE LIVESTOCK GRAZING TO HELP SUSTAIN NATIVE PLANT SPECIES. THE RESULTS WILL INFORM GRAZING PRACTICES FOR THE WESTERN U.S. WHERE LIVESTOCK PRODUCTION IS A SIGNIFICANT ECONOMIC DRIVER. THE OVERALL OBJECTIVE IS TO UNDERSTAND THE LIKELIHOOD OF DRYLAND STATE TRANSITIONS RESULTING FROM THE COMBINED EFFECTS OF MULTIPLE ENVIRONMENTAL DRIVERS AND DETERMINE TO WHAT EXTENT TRANSITIONS CAN BE PREVENTED USING STRATEGIC LIVESTOCK GRAZING, SUCH AS TARGETED GRAZING ON INVASIVE SPECIES. THE PROJECT WILL CO-PRODUCE DATA PRODUCTS WITH LAND MANAGEMENT PARTNERS FOR A RANGE OF PROJECTED FUTURES ACROSS LARGE SPATIAL SCALES TO INFORM DECISION-MAKING AMID NONSTATIONARY, NOVEL CONDITIONS, AND TO ENHANCE THE ABILITY OF MANAGERS TO SOLVE COMPLEX GLOBAL CHANGE CHALLENGES. THIS PROJECT WILL INTEGRATE EMPIRICAL DATA AND SIMULATION RESULTS FROM STEPWAT2, AN INDIVIDUAL-BASED PLANT MODEL THAT EXPLICITLY REPRESENTS FINE-SCALE ECOLOGICAL AND ENVIRONMENTAL PROCESSES RELEVANT FOR DRYLANDS. SIMULATIONS WILL BE USED TO TEST THE INDIVIDUAL AND COMBINED EFFECTS OF THESE DRIVERS UNDER A COMPREHENSIVE SET OF TRADITIONAL AND STRATEGIC GRAZING REGIMES TO QUANTIFY THE CONDITIONS WHERE INTERACTING ENVIRONMENTAL DRIVERS ARE LIKELY TO LEAD TO STATE TRANSITIONS AND WHETHER STRATEGIC GRAZING CAN SHIFT THE COMPETITIVE BALANCE BETWEEN NATIVE AND INVASIVE SPECIES AND ENHANCE ECOLOGICAL RESILIENCE. THE PROJECT WILL ADVANCE THE FIELD OF ECOLOGY BY PROVIDING NEW INSIGHTS INTO THE LIKELIHOOD OF STATE TRANSITIONS, ALONG WITH IDENTIFYING HOW PLANT COMMUNITY RESPONSES DIVERGE BASED ON LIFE HISTORY TRAITS AND RESOURCE AVAILABILITY. THIS PROJECT IS JOINTLY FUNDED BY POPULATION AND COMMUNITY ECOLOGY AND THE ESTABLISHED PROGRAM TO STIMULATE COMPETITIVE RESEARCH (EPSCOR). THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

COMMUNITY PROJECT FUNDING/CONGRESSIONALLY DIRECTED SPENDING - CONSTRUCTION

CONGRESSIONAL FUNDING OPRE

WV-TIME4K (TRAUMA INFORMED MINDFULNESS ENGAGEMENT) FOR KIDS

ADVANCE INSTITUTIONAL TRANSFERMATION AWARD: ADVANCING WOMEN IN SCIENCE, TECHNOLOGY, ENGINEERING AND MATH AT MARSHALL UNIVERSITY

RURAL RESIDENCY PLANNING AND DEVELOPMENT PROGRAM

DISCOVERY AND CHARACTERIZATION OF GENETIC MECHANISMS DRIVING STRESS-INDUCED ADDICTION VULNERABILITY

DETERMINING THE IMPACT OF SYNTHETIC COOLANTS ON ABUSE LIABILITY AND INITIATION-RELATED BEHAVIORS - PROJECT SUMMARY/ABSTRACT MENTHOL HAS BEEN A POPULAR FLAVOR OF NICOTINE-CONTAINING PRODUCTS. THIS, AT LEAST IN PART, IS DUE TO ITS ABILITY TO ENHANCE NICOTINE’S ACTIONS THAT CONTRIBUTE TO ADDICTION-RELATED BEHAVIORS. AS BANS ARE BEING IMPLE- MENTED TO LIMIT OR RESTRICT MENTHOL IN NICOTINE-CONTAINING PRODUCTS, NON-MENTHOL SYNTHETIC COOLANTS ARE INCREAS- INGLY USED IN VAPING PRODUCTS. SOME OF THESE SYNTHETIC COOLANTS EXHIBIT CHEMICAL STRUCTURES SIMILAR TO MENTHOL AND THIS HIGHLIGHTS THE CRITICAL NEED TO UNDERSTAND THE IMPACT OF SYNTHETIC COOLANTS ON NICOTINE’S ABUSE LIABILITY AND THEIR IMPACT ON INITIATION-RELATED BEHAVIORS. IF THEIR IMPACT REMAINS UNKNOWN, REGULATORY AUTHORITIES MAY NEVER UNDERSTAND THEIR RISK TO ADDICTION-RELATED BEHAVIORS AND OVERALL PUBLIC HEALTH. THUS, UNTIL THIS KNOWLEDGE GAP IS CLOSED, WE FACE THE RISK OF INCREASED SMOKING INITIATION, DECREASED CESSATION, AND A CUMULATIVE EFFECT OF A GROWING POPULATION OF LIFELONG VAPERS IN AMERICA AS THE USE OF SYNTHETIC COOLANTS INCREASES. OUR OVERALL GOAL IS TO DETERMINE THE IMPACT OF SYNTHETIC COOLANTS ON NICOTINE’S ABUSE LIABILITY AND INITIATION-RELATED BEHAVIORS. TO ADDRESS THIS, WE WILL UTILIZE A NOVEL VAPOR SELF-ADMINISTRATION ASSAY THAT WILL PROVIDE HIGH TRANSLATIONAL VALUE. WE HYPOTHESIZE THAT DIRECTLY LINKING SELF-ADMINISTRATION BEHAVIOR TO BIOMARKERS OF NICOTINE ABUSE LIABILITY (NACHR UPREGULATION AND CHANGES IN NEUROPHYSIOLOGY) WILL DETERMINE THE SPECIFIC IMPACT OF SYNTHETIC COOLANTS ON KEY ASPECTS OF VAPING-RELATED BEHAVIOR. THEREFORE, THIS WILL PROVIDE A SCIENTIFIC FOUNDATION FOR FUTURE REGULATORY AC- TIONS THAT TARGET SYNTHETIC COOLANTS. THE RATIONALE BEHIND THIS COMES FROM THE APPLICANT’S PREVIOUS EXPERIENCE IN CHARACTERIZING THE IMPACT OF MENTHOL ON NICOTINE’S ABUSE LIABILITY AND PRELIMINARY INVESTIGATIONS INTO SYNTHETIC COOLANTS IMPACT ON NICOTINE REINFORCEMENT-RELATED BEHAVIOR. WE WILL IDENTIFY SYNTHETIC COOLANT-SPECIFIC CHANGES IN NICOTINE’S ABUSE LIABILITY WITH THREE SPECIFIC AIMS. FIRST, WE WILL UTILIZE E-VAPE NICOTINE SELF-ADMINISTRATION AS- SAYS IN MICE TO EXAMINE INITIATION AND NICOTINE REINFORCEMENT IN THE ABSENCE AND PRESENCE OF SYNTHETIC COOL- ANTS. SECOND, WE WILL USE THE BRAINS FROM THE FIRST AIM TO EXAMINE NACHR UPREGULATION AS A BIOMARKER FOR NICO- TINE ABUSE LIABILITY AND PROVIDE A DIRECT LINK BETWEEN SELF-ADMINISTRATION BEHAVIOR AND NACHR UPREGULATION. THIRD, WE WILL EXAMINE CHANGES IN NEUROPHYSIOLOGY VIA ELECTROPHYSIOLOGY AND FIBER PHOTOMETRY. THIS APPROACH IS INNOVATIVE, IN THE APPLICANT'S OPINION, BECAUSE IT ESTABLISHES A DIRECT CORRELATION BE- TWEEN VAPING-RELATED SELF-ADMINISTRATION AND NACHR UPREGULATION AS WELL AS CHANGES IN NEUROPHYSIOLOGY IN AN IN VIVO MODEL AND UTILIZES THE EXACT SAME ENDS AND E-LIQUIDS POPULAR WITH HUMAN ADOLESCENT VAPERS. THIS IS COMPLEMENTED BY THE USE OF A NOVEL MOUSE EXPRESSING Α4-MCHERRY AND Α6-GFP NACHR SUBUNITS THAT ALLOW ANALYSIS OF UPREGULATION WITHOUT THE USE OF ANTIBODIES. THE PROPOSED RESEARCH IS SIGNIFICANT, BECAUSE IT WILL ES- TABLISH A SCIENTIFIC FOUNDATION TO PROPOSE FUTURE REGULATIONS REGARDING SYNTHETIC COOLANTS TO IMPROVE PUBLIC HEALTH.

DIRECTED SEQUENTIAL ASSEMBLY VIA DNA BASED NANOSTRUCTURES

TRANSCRIPTION AS SEQUENCING - TAS

FY2017 COMMERCIAL DRIVER'S LICENSE PROGRAM IMPLEMENTATION (CDLPI)

CHARACTERIZATION OF MENTHOL'S EFFECT ON NICOTINE REWARD AND NICOTINIC RECEPTOR NEUROBIOLOGY

THE PURPOSE OF THIS AWARD TO THE MARSHALL UNIVERSITY RESEARCH CORPORATION IS TO DEVELOP STRONG PARTNERSHIPS WITH FEDERAL AND STATE STAKEHOLDERS TO PROVIDE: (1) A PAPERLESS, MOBILE CDL SYSTEM TO JURISDICTIONS OF VARIOUS SIZES TO REDUCE ERRORS, INCREASE FRAUD DETECTION CAPABILITIES AND IMPROVE THE OVERALL CDL DATA EXCHANGE BOTH INTERNALLY (E.G., JURISDICTION CDL SYSTEMS) AND EXTERNALLY (E.G., CSTIMS) (2) KNOWLEDGE TESTING CAPABILITIES THAT AUTOMATE JURISDICTION TESTING SYSTEMS TO MEET FEDERAL GUIDELINES AND STANDARDS AND REDUCE THE COST OF EXPENSIVE CHANGES AND (3) CONTINUE TO SUPPORT EXAMINERS AND ADMINISTRATORS BY MAKING CDL TESTING MORE EFFICIENT AND EFFECTIVE.

TRAILBLAZER SCHOLARS PROGRAM

THIS AWARD TO THE MARSHALL UNIVERSITY RESEARCH CORPORATION IS FOR RESEARCH TO ENABLE MORE EFFECTIVE ENFORCEMENT AND ENGINEERING EFFORTS TO HELP REDUCE THE NUMBER AND SEVERITY OF CMV CRASHES IN WEST VIRGINIA THE FOLLOWING ARE THE OBJECTIVES 1 GENERATE AT LEAST 10 CMV CRASH DEFINITIONS IMPORTANT TO WEST VIRGINIA STAKEHOLDERS 2 GENERATE A PROTOTYPE CMV CRASH DASHBOARD THAT ALLOWS INTERACTION WITH THE CRASH DATA DEFINED BY THE PREVIOUS OBJECTIVE 3 BUILD A CRASH LOCATOR TOOL CAPABLE OF DISPLAYING THE LOCATION OF CRASHES ON A MAP 4 REVIEW 100 OF THE CMV RELATED CRASH RECORDS IN WV FOR THE MOST RECENT 5 YEARS AND EVALUATE THE LOCATION ACCURACY 5 GENERATE A LATITUDE LONGITUDE, ROUTE ID AND MILEPOINT CONSISTENT WITH THE WVDOT LINEAR REFERENCE SYSTEM FOR 100 OF THE CMV CRASH RECORDS THAT CONTAIN LOCATION INFORMATION 6 GENERATE A HOT SPOT ANALYSIS MAP FOR AT LEAST ONE TYPE OF CMV CRASH DEFINED IN OBJECTIVE 1

CAREER: AN INTEGRATED APPROACH TO UNDERSTANDING THE INTERPLAY BETWEEN TELOMERE BIOLOGY, FLOWERING TIME REGULATION, AND PLANT REPRODUCTIVE FITNESS -TELOMERES ARE IMPORTANT STRUCTURES AT THE ENDS OF CHROMOSOMES THAT PROTECT DNA FROM DEGRADATION AND IN HUMANS CONTRIBUTE TO PREVENTING CANCER AND PREMATURE AGING. THE LENGTH OF TELOMERIC DNA IN DIFFERENT ANIMALS AND PLANTS VARIES SUBSTANTIALLY, BUT THE SIGNIFICANCE OF THIS VARIATION FOR ORGANISMAL INTEGRITY IS NOT FULLY UNDERSTOOD. THIS STUDY WILL ANALYZE THE IMPORTANCE OF HAVING LONG OR SHORT TELOMERES FOR PLANTS GROWN IN GOOD OR STRESSFUL ENVIRONMENTAL CONDITIONS. SPECIFICALLY, IT WILL EVALUATE THE NUMBER OF SEEDS PRODUCED AND THE TIMING OF FLOWERING INITIATION AS A MEASURE OF PLANT ADAPTATION TO STRESS. THE PROJECT WILL ALSO HELP EXTEND HANDS-ON RESEARCH OPTIONS FOR UNDERGRADUATE STUDENTS. IT WILL ALSO PROVIDE MANY OPPORTUNITIES FOR STEM-THEMED OUTREACH ACTIVITIES TO INCREASE SCIENTIFIC LITERACY AND TO ADVANCE CAREER PREPARATION FOR THE NEXT GENERATIONS OF BIOLOGY STUDENTS. TELOMERES ARE EVOLUTIONARILY CONSERVED PROTEIN-DNA COMPLEXES THAT CAP LINEAR EUKARYOTIC CHROMOSOMES AND ENSURE PROPER GENOME MAINTENANCE AND STABILITY. IN HUMANS, THE LENGTH OF TELOMERIC DNA IS OFTEN VIEWED AS ONE OF THE MOST ACCURATE CELLULAR MARKERS OF BIOLOGICAL AGE. HOWEVER, IN PLANTS AND MANY OTHER ORGANISMS THE SIGNIFICANCE OF TELOMERE LENGTH CHANGES OVER ORGANISMAL LIFESPAN OR IN RESPONSE TO ENVIRONMENTAL STRESSORS IS LARGELY UNCLEAR. RECENT FINDINGS IN THE MODEL PLANT ARABIDOPSIS THALIANA DEMONSTRATED THAT NATURAL VARIATION IN TELOMERE LENGTH INFLUENCES REPRODUCTIVE FITNESS AND THE TIMING OF FLORAL TRANSITION. NEVERTHELESS, THE EXACT MOLECULAR AND GENETIC MECHANISMS LINKING TELOMERE LENGTH WITH PLANT DEVELOPMENTAL TRAITS ARE UNKNOWN. THROUGH SEVERAL TRANSCRIPTOME AND CANDIDATE GENE ANALYSIS PROJECTS THIS STUDY WILL ELUCIDATE THE FUNCTIONAL CROSSTALK BETWEEN TELOMERE LENGTH REGULATION AND FLOWERING TIME CONTROL. IT WILL ALSO CHARACTERIZE THE EFFECTS OF TELOMERE LENGTH VARIATION ON PLANT FITNESS AND DECIPHER MOLECULAR MECHANISMS ACTING ON EXTREME TELOMERE LENGTH PHENOTYPES. FINALLY, THE PROJECT WILL AID IN DEVELOPING CAREER-SHAPING RESEARCH AND EDUCATIONAL EXPERIENCES FOR UNDERGRADUATE STUDENTS. OVERALL, THE PROPOSED STUDIES WILL HELP DISCOVER THE INTRIGUING FUNCTIONAL ROLES THAT TELOMERES PLAY IN MEDIATING LIFE-HISTORY TRAIT VARIATION AND TRADE-OFFS. THIS PROJECT IS JOINTLY FUNDED BY THE GENETIC MECHANISMS PROGRAM, THE DIVISION OF MOLECULAR AND CELLULAR BIOSCIENCES, AND THE ESTABLISHED PROGRAM TO STIMULATE COMPETITIVE RESEARCH (EPSCOR). THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

INTEGRATED SENSING USING DNA NANOARCHITECTURES

BUSINESS SITE DEVELOPMENT

THE CHIRALITY-DIRECTED SELF-ASSEMBLY: APPLICATION TOWARD DESIGN-FLEXIBLE RENEWABLE/RECYCLABLE CATALYSTS -WITH THE SUPPORT OF THE CHEMICAL CATALYSIS PROGRAM IN THE DIVISION OF CHEMISTRY, PROFESSOR MOTEKI AND PROFESSOR DAY OF MARSHALL UNIVERSITY ARE STUDYING RECYCLABLE/RENEWABLE CATALYSTS WHICH PLAY A CRUCIAL ROLE IN MANY INDUSTRIAL PROCESSES, WHICH INCLUDE, BUT NOT LIMITED TO, PETROLEUM REFINING, CHEMICAL PRODUCTION, PHARMACEUTICALS, POLYMER MANUFACTURING, AND ENERGY PRODUCTION. CATALYSTS SIGNIFICANTLY LOWER THE PRODUCTION COST BY ACCELERATING THE PRODUCTION RATE WHILE REDUCING THE AMOUNT OF RAW MATERIALS AND ENERGY NEEDED, LEADING DOMESTIC INDUSTRIES TO BECOME HIGHLY COMPETITIVE IN THE GLOBAL MARKET. ENHANCING RECYCLABILITY REDUCES A NATION'S RELIANCE ON FOREIGN INDUSTRIES FOR MATERIALS, CREATING A MORE SELF-SUFFICIENT AND SUSTAINABLE ECONOMY. THE DEPARTMENT OF CHEMISTRY AT MARSHALL UNIVERSITY, LOCATED IN HUNTINGTON, WEST VIRGINIA, SERVES STUDENTS FROM THE TRI-STATE AREA OF WEST VIRGINIA, OHIO, AND KENTUCKY. THE FUNDS WILL BE UTILIZED TO HIRE AND TRAIN REGIONAL DOMESTIC STUDENTS THROUGH CUTTING-EDGE RESEARCH, PREPARING THEM TO BECOME HIGHLY SKILLED INDUSTRY WORKERS. THE EDUCATIONAL ACTIVITIES WILL ALSO INCLUDE STUDENT-LED HOMETOWN OUTREACH IN WEST VIRGINIA, INSPIRING THE NEXT GENERATION OF INNOVATORS. WITH THE SUPPORT OF THE CHEMICAL CATALYSIS PROGRAM IN THE DIVISION OF CHEMISTRY, PROFESSOR MOTEKI AND PROFESSOR DAY OF MARSHALL UNIVERSITY ARE STUDYING DESIGN AND CONSTRUCT RENEWABLE/RECOVERABLE HOMOGENEOUS/HETEROGENEOUS CATALYSTS USING CHIRALITY-DIRECTED SELF-ASSEMBLY AS AN UNDERLYING CORE TECHNOLOGY. CATALYSTS ARE ESSENTIAL FOR INDUSTRIAL PROCESSES, FROM PRODUCING NEW PHARMACEUTICALS TO MANUFACTURING VARIOUS MATERIALS. CATALYST RECYCLING SIGNIFICANTLY BENEFITS THE ECONOMY THROUGH RESOURCE CONSERVATION AND COST REDUCTIONS. THE PROJECT SEEKS TO CREATE A MORE PRACTICAL/ECONOMICAL APPROACH TO CATALYST RECYCLING BY INCORPORATING HIGHLY SELECTIVE/EFFICIENT REVERSIBLE SELF-ASSEMBLY TO GENERATE A DESIGN-FLEXIBLE RECYCLABLE/RENEWABLE CATALYST SYSTEM. THIS PROJECT WILL APPLY CHIRALITY-DRIVEN SELF-ASSEMBLY TO DESIGN AND CONSTRUCT (1) A HOMOGENEOUS CATALYSTS RECYCLING SYSTEM WHERE SOLUBLE CATALYSTS ARE RECOVERED FROM A REACTION MIXTURE THROUGH SELF-ASSEMBLY USING MAGNETIC BEADS, (2) ?IN-SITU? RENEWABLE CATALYST STATIONARY PHASE FOR CONTINUOUS FLOW REACTOR WHERE CATALYSTS ARE EXCHANGED WITHOUT AFFECTING FUNCTIONAL INTEGRATION OF THE CATALYST SUPPORT, AND (3) RECYCLABLE ?ENZYME-LIKE? SELF-ASSEMBLED CATALYTIC DENDRONIZED POLYMER WHERE INTERNAL/EXTERNAL POLARITY DIFFERENCES ENHANCES CATALYTIC PERFORMANCE THROUGH A POLARITY GRADIENT PUMP MECHANISM. THE SUCCESSFUL COMPLETION OF THE PROPOSED RESEARCH WILL LEAD TO NEW DESIGNS OF RENEWABLE/RECOVERABLE CATALYTIC SYSTEMS WITH REVOLUTIONARY, RATHER THAN INCREMENTAL, IMPROVEMENT IN DESIGN FLEXIBILITY OVER CURRENT STATE-OF-THE-ART SYSTEMS. ITS IMPORTANCE IS DUE TO ADVANCES IN CONSTRUCTING A MULTI-DOMAIN, MULTI-CATALYTIC SUPRAMOLECULAR STRUCTURE THROUGH COORDINATING COVALENT BONDS. IN ADDITION, THE PROPOSED SYSTEM WILL BE APPLIED TO A BROADER RANGE OF MULTI-STEP ORTHOGONAL TANDEM CATALYSIS WITH A HIGHER DEGREE OF SELF-SUFFICIENCY. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

INTERPRETATION OF IGNITABLE LIQUID RESIDUES IN FIRE DEBRIS ANALYSIS: EFFECT OF COMPETITIVE ADSOPRTION, DEVELOPMENT OF AN EXPERT SYSTEM AND ASSESSMENT

CAREER: PHYSIOLOGICAL RESPONSES OF NEURAL STEM CELLS TO LOW-LEVEL SILVER NANOPARTICLES.

MRI: TRACK 1 ACQUISITION OF A LIQUID CHROMATOGRAPH-MASS SPECTROMETER SYSTEM TO ENHANCE MULTIDISCIPLINARY RESEARCH AND EDUCATION AT MARSHALL UNIVERSITY -THIS AWARD IS JOINTLY SUPPORTED BY THE MAJOR RESEARCH INSTRUMENTATION (MRI) PROGRAM, THE DIVISION OF CHEMISTRY RESEARCH INSTRUMENTATION PROGRAM, AND THE MATHEMATICAL AND PHYSICAL SCIENCES DIRECTORATE OFFICE OF STRATEGIC INITIATIVES. MARSHALL UNIVERSITY IS ACQUIRING A LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY (LC-MS/MS) SYSTEM TO SUPPORT THE RESEARCH OF PROFESSOR LESLIE M. FROST AND HER COLLEAGUES LAUREN R. WAUGH, ROSALYNN QUINONES AND SHIN A. MOTEKI. THIS INSTRUMENT FACILITATES RESEARCH ACROSS VARIOUS FIELDS, INCLUDING ORGANIC CHEMISTRY, BIOCHEMISTRY, FORENSICS, AND PHARMACEUTICS AND ENHANCES THE CAPABILITIES FOR SEPARATION, QUANTIFICATION, AND IDENTIFICATION OF BOTH SMALL AND LARGE MOLECULES. THE LC-MS/MS SYSTEM IS A HIGH-RESOLUTION, HIGHLY SENSITIVE AND PRECISE INSTRUMENT INTENDED FOR THE QUALITATIVE AND QUANTITATIVE ANALYSIS OF DIVERSE MOLECULAR CLASSES. IT IS DESIGNED TO IDENTIFY UNKNOWN SMALL MOLECULES, CHARACTERIZE ORGANIC COMPOUNDS AND ORGANOCATALYSTS, AND ANALYZE COMPLEX MIXTURES OF METABOLITES, PEPTIDES, OR MODIFIED PROTEINS. THE SYSTEM SERVES BOTH EDUCATIONAL AND RESEARCH USERS, ENABLING MEASUREMENTS OVER MULTIPLE SAMPLE TYPES. THE INSTRUMENT OFFERS PRACTICAL TRAINING AND RESEARCH OPPORTUNITIES FOR NUMEROUS SENIOR PERSONNEL, GRADUATE STUDENTS, AND UNDERGRADUATES WHILE ALSO FOSTERING COLLABORATIVE RESEARCH AND EDUCATIONAL PROJECTS WITH NEARBY INSTITUTIONS SUCH AS THE UNIVERSITY OF CHARLESTON, AND MANY STUDENTS IN WEST VIRGINIA AND THE SURROUNDING TRI-STATE AREA. THE TYPES OF ANALYSIS SUPPORTED BY THIS INSTRUMENT ENHANCE ORGANIC CHEMISTRY RESEARCH BY ENABLING INVESTIGATORS TO CHARACTERIZE MODIFIED PEPTIDES AND PROTEINS IN DISEASE STATES, IDENTIFY UNDECLARED AND ADULTERATED DRUGS IN WEIGHT-LOSS SUPPLEMENTS, EXPLORE XYLAZINE METABOLISM IN HUMAN LIVER MICROSOMES (WITH AND WITHOUT OPIOID CO-EXPOSURE), AND DESIGN/CONSTRUCT RENEWABLE OR RECOVERABLE CATALYSTS. THE INSTRUMENT ALSO ENHANCES MARSHALL UNIVERSITY?S SPECTROMETRY FACILITIES BY ITS INTEGRATION INTO THE CURRICULA OF COURSES AND OFFERS DIRECT TRAINING TO STUDENTS AND FURTHER DEVELOPS THEIR TECHNICAL SKILLS, ALLOWING THEM TO ACTIVELY IMPROVE THEIR UNDERSTANDING OF APPLIED SCIENCE BY BACKING UP LECTURE CONTENT. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

THE PREVENTION EMPOWERMENT PARTNERSHIP (PEP), OF MARSHALL UNIVERSITY RESEARCH CORPORATION, IS A COLLABORATIVE COMMITTEE OF COMMUNITY-BASED ORGANIZATIONS AND COMMUNITY LEADERS THAT PARTNER TO INCREASE ACCESS TO PREVENTION SERVICES FOR YOUTH AND FAMILIES IN CABELL COUNTY AND THROUGHOUT THE STATE OF WV WHERE APPROPRIATE. FUNDING FROM THIS GRANT WILL HELP CREATE THE SHIELD PROJECT.  SHIELD IS A CONCEPT OF COMMUNITY OWNERSHIP AND SAFETY THAT WILL PROTECT YOUTH AND THEIR FAMILIES AND WILL EMPOWER THEM TO ADDRESS THE EFFECTS OF SUBSTANCE USE DISORDER AND PARTNER WITH THEIR COMMUNITIES TO AFFECT POSITIVE CHANGE.             WV IS 'GROUND ZERO' OF A NATIONAL CRISIS, AND THE SITES INCLUDED IN THIS PROPOSAL ARE AREAS HARDEST HIT THAT ALSO MEET THE PRIORITY AREAS IDENTIFIED FOR THIS GRANT.  CABELL COUNTY AND SURROUNDING AREAS HAVE FACED AN UNPRECEDENTED OPIOID EPIDEMIC FOR THE LAST DECADE.  THE CASCADE OF PROBLEMS EMANATING FROM THIS HAS DISPROPORTIONATELY AFFECTED CHILDREN AND THEIR FAMILIES AT-RISK FOR BEHAVIORAL HEALTH PROBLEMS INCREASING THE NEED FOR SELECTIVE AND INDICATED PREVENTION SERVICES, EARLY INTERVENTION, OUTREACH, AND TREATMENT.   THIS PROJECT WILL DEVELOP AND IMPLEMENT A COMPREHENSIVE, DATA-DRIVEN COORDINATED PLAN TO ADDRESS CHALLENGES RESULTING FROM THE OPIOID CRISIS THAT IMPACT YOUTH, THEIR FAMILIES, AND COMMUNITY SAFETY.            THE SHIELD PROJECT WILL REDUCE TRAUMATIC STRESS FOR YOUTH IMPACTED BY OPIOID USE DISORDER IN THE IDENTIFIED AREA.  PEP WILL ACCOMPLISH THIS BY INTEGRATING EVIDENCE-BASED PREVENTION, INTERVENTION, DIVERSION, PROBLEM IDENTIFICATION, AND TREATMENT SERVICES FOR CHILDREN AND THEIR FAMILIES WITH ALREADY EXISTING EDUCATION, JUSTICE, AND TREATMENT SERVICE SYSTEMS, AND BY INCREASING THE CAPACITY OF COMMUNITY ORGANIZATIONS TO BETTER IDENTIFY AND SERVE YOUTH AND FAMILIES SUFFERING FROM TRAUMATIC STRESS DUE TO THE DEVASTATING EFFECTS OF THE OPIOID EPIDEMIC. ASSESSMENT OF NEEDS, DATA COLLECTION, PLAN DEVELOPMENT, QUARTERLY AND ANNUAL REPORTING WILL BE BUILT INTO THIS PROGRAM AND WILL BE DEVELOPED AND BASED ON THE REQUIRED PERFORMANCE MEASURES AS REQUIRED BY OJJDP'S ONLINE PERFORMANCE MEASUREMENT TOOL, AS WELL AS ANALYSIS OF THE PRIDE RISK BEHAVIOR SURVEY.

BEHAVIORAL HEALTH WORKFORCE EDUCATION AND TRAINING (BHWET) PROGRAM

PREDICTION AND EARLY IDENTIFICATION OF HARMFUL ALGAL BLOOM IN RIVERINE SYSTEMS

APPALACHIAN MENTAL HEALTH AWARENESS TRAINING HUB (MHAT HUB) - MU PROPOSES TO EXPAND OUR EXISTING, EXTENSIVE TRAINING INFRASTRUCTURE TO PROVIDE MENTAL HEALTH AWARENESS TRAINING TO INDIVIDUALS INCLUDING SCHOOL PERSONNEL; YOUTH LEADERS IN HIGH SCHOOL AND INSTITUTIONS OF HIGHER EDUCATION INCLUDING THOSE STUDYING CRIMINAL JUSTICE-RELATED TOPICS; LAW ENFORCEMENT AND OTHER EMERGENCY FIRST RESPONDERS; VETERANS ASSISTANCE PROGRAMS; ARMED SERVICES MEMBERS AND THEIR FAMILIES, FAITH COMMUNITIES, AND COMMUNITY COALITIONS ON HOW TO APPROPRIATELY AND SAFELY IDENTIFY AND RESPOND TO INDIVIDUALS WITH MENTAL HEALTH DISORDERS. ADDITIONALLY, TRAINING FOR FIRST RESPONDERS, LAW ENFORCEMENT, AND OTHERS WHO RESPOND TO CRISIS SITUATIONS WILL INCLUDE HOW TO EMPLOY DE-ESCALATION TECHNIQUES PARTICULARLY WITH INDIVIDUALS EXPERIENCING SERIOUS MENTAL ILLNESS (SMI) AND/OR SERIOUS EMOTIONAL DISEASE (SED). MU WILL COLLABORATE WITH COMMUNITY COALITIONS TO PROVIDE ‘TRAIN THE TRAINER” OPPORTUNITIES TO ASSIST WITH SUSTAINABILITY OF THE TRAINING PROGRAM AND TO SUPPORT EXPANDING THE TRAINING TO MORE REMOTE AND UNDERSERVED AREAS. COLLABORATIVES WILL ALSO BE LEVERAGED TO EXPAND ACCESS TO RESOURCE INFORMATION REGARDING ASSISTANCE WITH SEVERE MENTAL HEALTH ISSUES. MU’S PROPOSED APPALACHIAN MENTAL HEALTH AWARENESS TRAINING HUB (MHAT HUB) WILL PROVIDE TRAINING TO 2,700 INDIVIDUALS THROUGHOUT THE WEST VIRGINIA (WV) BUREAU FOR BEHAVIORAL HEALTH (BBH) REGION 5, WHICH IS THE MOST POPULOUS REGION IN WV AND INCLUDES THE FOLLOWING COUNTIES: BOONE, CABELL, CLAY, KANAWHA, LINCOLN, LOGAN, MASON, MINGO, PUTNAM, AND WAYNE COUNTIES. THE OVERALL PURPOSE OF THE MHAT HUB IS TO CREATE A MODEL THAT CAN ADAPTED THROUGHOUT WV TO INCREASE THE EFFECTIVENESS AND SAFETY OF SERVICES PROVIDED TO THOSE EXPERIENCING MENTAL HEALTH ISSUES ENHANCING THE SAFETY AND EFFICACY OF SERVICES PROVIDED OUT OF THE DIRECT CARE SETTING. GOALS WILL INCLUDE: GOAL 1. INCREASE NUMBER OF INDIVIDUALS (SUCH AS: SCHOOL PERSONNEL; YOUTH LEADERS IN HIGH SCHOOL AND INSTITUTIONS OF HIGHER EDUCATION INCLUDING THOSE STUDYING CRIMINAL JUSTICE-RELATED TOPICS; LAW ENFORCEMENT AND OTHER EMERGENCY FIRST RESPONDERS; PROFESSIONALS SERVING VETERANS; ARMED SERVICES MEMBERS AND THEIR FAMILIES, FAITH COMMUNITIES, AND COMMUNITY COALITIONS) ABLE TO RECOGNIZE THE SIGNS AND SYMPTOMS OF MENTAL HEALTH DISORDERS AND APPROPRIATELY RESPOND, PARTICULARLY SMI AND/OR SED. GOAL 2. TRAIN EMERGENCY FIRST RESPONDERS INCLUDING LAW ENFORCEMENT, INDIVIDUALS SERVING VETERANS AND MILITARY PERSONNEL TO IDENTIFY PERSONS WITH A MENTAL HEALTH DISORDER AND EFFECTIVELY EMPLOY CRISIS DE-ESCALATION TECHNIQUES. GOAL 3. ENHANCE CURRENT AND ESTABLISH NEW LINKAGES WITH SCHOOL AND/OR COMMUNITY-BASED MENTAL HEALTH-RELATED AGENCIES TO REFER INDIVIDUALS WITH THE SIGNS OR SYMPTOMS OF MENTAL ILLNESS TO APPROPRIATE SERVICES.

WORKFORCE TRAINING

UNIVERSITY CENTER 2011

CAREER & TECHNICAL EDUCATION

DEVELOP UNDERWATER INSPECTION METHODS TO DETERMINE THE CONDITION OF PILE FOUNDATIONS EMBEDDED IN SOIL.

CC*DNI MARSHALL UNIVERSITY DATA DRIVEN NETWORKING INFRASTRUCTURE FOR THE CAMPUS AND RESEARCHER

MU SCHOOL PSYCHOLOGY EQUIPPING MENTAL HEALTH PROVIDERS - MARSHALL UNIVERSITY SCHOOL PSYCHOLOGY PROGRAM- EQUIPPING MENTAL HEALTH PROVIDERS IN SCHOOLS, HEREINAFTER REFERRED TO AS EQUIPPING PROVIDERS, ADDRESSES AN ALARMING SHORTAGE OF QUALIFIED MENTAL HEALTH SCHOOL PERSONNEL IN WEST VIRGINIA (WV) TO SERVE SCHOOL-AGED (PK-12) STUDENTS WITH SOCIAL, EMOTIONAL, AND BEHAVIORAL NEEDS DUE TO PHENOMENA LIKE PRENATAL SUBSTANCE EXPOSURE, COMPLEX TRAUMATIC STRESS, ADVERSE CHILDHOOD EXPERIENCES, AND/OR ADVERSE COMMUNITY ENVIRONMENTS. SCHOOL PSYCHOLOGISTS CAN PARTNER WITH FAMILIES, TEACHERS, SCHOOL ADMINISTRATORS, AND OTHER PROFESSIONALS TO CREATE SAFE, HEALTHY, AND SUPPORTIVE LEARNING ENVIRONMENTS THAT STRENGTHEN CONNECTIONS BETWEEN HOME, SCHOOL, AND THE COMMUNITY. EQUIPPING PROVIDERS WILL ENABLE 15 SCHOOL PSYCHOLOGY CANDIDATES TO SPEND MORE TIME IN SCHOOLS PROVIDING EVIDENCE-BASED INTERVENTIONS TO PK-12 STUDENTS IN HIGH NEED AREAS, AND IT WILL EQUIP THE CANDIDATES WITH THE NEEDED ASSESSMENT TOOLS TO PROVIDE IMPROVED SERVICES TO CHILDREN AND YOUTH. PROVIDING STIPENDS TO FIELD SUPERVISORS WILL INCREASE MENTORING SUPPORT FOR CANDIDATES, IMPROVING THE QUALITY OF INTERVENTIONS FOR PK-12 STUDENTS. THE ENHANCED SUPPORT WILL BE MONITORED AND ASSESSED THROUGH SURVEYS AND TIME LOGS. THE EQUIPPING PROVIDERS PROGRAM WILL SUPPORT WEST VIRGINIA YOUTH BY PROVIDING SCHOOL-BASED MENTAL HEALTH SERVICES THAT WILL INCREASE ACCESS TO CARE, ALLOW FOR EARLY IDENTIFICATION AND TREATMENT OF MENTAL HEALTH ISSUES, REDUCE BEHAVIORAL ISSUES, AND FOSTER BETTER MENTAL HEALTH AND ACADEMIC OUTCOMES FOR PK-12 STUDENTS.

SODIUM PUMP, SEX HORMONES, AND THROMBOSIS - PROJECT SUMMARY/ABSTRACT INCREASED THROMBOSIS RISK HAS BEEN OBSERVED IN SPECIFIC CONDITIONS, SUCH AS HEART FAILURE AND SEX HORMONE THERAPY, YET THE UNDERLYING MECHANISMS REMAIN UNCLEAR. PLATELET ACTIVATION AND AGGREGATION ARE CRITICAL COMPONENTS OF THROMBOSIS, THOUGH THE FUNCTION OF MANY PLATELET PROTEINS REMAIN UNEXPLORED. SODIUM/POTASSIUM ATPASE (NKA), ALSO KNOWN AS THE SODIUM PUMP, IS A CRUCIAL PLASMA MEMBRANE PROTEIN COMPOSED OF Α AND Β SUBUNITS. NKA PLAYS A VITAL ROLE IN MAINTAINING SODIUM AND POTASSIUM GRADIENTS, CELL VOLUME, AND OVERALL CELLULAR HOMEOSTASIS. HUMAN CELLS EXPRESS FOUR Α AND THREE Β SUBUNITS, FORMING DIFFERENT NKA ISOFORMS IN A TISSUE- OR CELL-SPECIFIC MANNER. THE Α1 SUBUNIT IS UBIQUITOUSLY EXPRESSED, WITH PROTEOMIC STUDIES SUGGESTING Α1Β3 AS THE DOMINANT ISOFORM IN PLATELETS. HOWEVER, THE ROLE OF NKA IN PLATELET FUNCTION HAS YET TO BE SYSTEMATICALLY STUDIED. USING ATP1A1 HETEROZYGOUS (Α1+/−) MICE AND A 7.5% FECL3-INDUCED CAROTID ARTERY INJURY THROMBOSIS MODEL, WE FOUND THAT Α1 HAPLODEFICIENCY SIGNIFICANTLY INHIBITED THROMBOSIS IN MALE MICE, BUT NOT IN FEMALES, AND REDUCED ADP-INDUCED PLATELET AGGREGATION IN VITRO. ALPHA1 HAPLODEFICIENCY DID NOT ALTER THE NKA’S PUMP FUNCTION IN PLATELETS. TREATING MICE WITH LOW DOSES OF OUABAIN OR MARINOBUFAGENIN, BOTH POTENT NKA INHIBITORS, ALSO MARKEDLY INHIBITED THROMBOSIS IN VIVO. ADDITIONALLY, OUABAIN DOSE-DEPENDENTLY INHIBITED ADP-INDUCED PLATELET AGGREGATION IN CERTAIN INDIVIDUALS. IMMUNOPRECIPITATION-IMMUNOBLOTTING ASSAYS REVEALED THAT Α1 BINDS TO P2Y12, WHICH CONTAINS A LEUCINE-GLYCINE-LEUCINE (LGL) MOTIF THAT MEDIATES THE INTERACTION OF SOME PLATELET G PROTEIN-COUPLED RECEPTORS (GPCRS). MUTATION OF THE LGL MOTIF TO SERINE- PHENYLALANINE-THREONINE (SFT) SIGNIFICANTLY REDUCED THE P2Y12-NKA Α1 INTERACTION. IN WT MICE, FEMALES EXHIBITED ELEVATED PLATELET Α1 LEVELS COMPARED TO MALES, AND Α1+/− MICE HAD HIGHER TESTOSTERONE LEVELS THAN THEIR WT LITTERMATES. WHILE GONADECTOMY DID NOT AFFECT THROMBOSIS IN FEMALE Α1+/− OR WT MICE, IT SIGNIFICANTLY ENHANCED THROMBOSIS IN MALE Α1+/− MICE, SUGGESTING AN INTERPLAY BETWEEN NKA Α1 AND SEX HORMONES IN THROMBOSIS REGULATION. IN THIS PROJECT, WE WILL TEST THE HYPOTHESIS THAT Α1 MODULATES PLATELET ACTIVATION BY FINE- TUNING THE FUNCTION OF LGL-CONTAINING GPCRS, CONTRIBUTING TO THE ELEVATED THROMBOSIS INCIDENCE IN HEART FAILURE PATIENTS AND THOSE UNDERGOING SEX HORMONE TREATMENTS OR GONADECTOMY. AIM 1 WILL CLARIFY HOW THE PLATELET NKA Α1 SUBUNIT REGULATES THE FUNCTION OF LGL-CONTAINING GPCRS. AIM 2 WILL ASSESS WHETHER THE NKA Α1 SUBUNIT IS A DETERMINING FACTOR IN THE HEIGHTENED THROMBOSIS RISK LINKED TO SEX HORMONES. THIS RESEARCH AIMS TO PROVIDE NOVEL MECHANISTIC INSIGHTS INTO THE ROLE OF NKA, CARDIOTONIC STEROIDS, AND SEX HORMONES IN PLATELET BIOLOGY AND THROMBOSIS, ULTIMATELY SUPPORTING THE DEVELOPMENT OF INNOVATIVE, SAFER THERAPEUTIC STRATEGIES.

RCBI AERO

ACCELERATE FORWARD

THE MOMENTUM PROJECT (MOMENTUM) WILL SUPPORT WEST VIRGINIA'S ENTREPRENEURS AND SMALL-BUSINESSPEOPLE THROUGH A ROBUST MENU OF SERVICES INCLUDING MENTORSHIP, PRODUCT DESIGN AND PROTOTYPING, TECHNICAL ASSISTANCE, DIGITAL LITERACY, ACCESS TO FINANCING, WORKFORCE DEVELOPMENT, AND THE DEVELOPMENT OF AN ENTREPRENEUR PIPELINE. MOMENTUM'S ACTIVITIES WILL ENHANCE THE ECONOMIC RESILIENCY OF THE STATE, SUPPORT A DIVERSE ARRAY OF ENTREPRENEURS TO MAKE THE WV ECONOMY AS INCLUSIVE AS POSSIBLE, AND TARGET INDUSTRIES MARKED FOR GROWTH SUCH AS FOOD AND AGRICULTURE, MEDICAL MANUFACTURING, TECHNOLOGY, AND OUTDOOR RECREATION. EMPHASIZING DIRECT TECHNICAL ASSISTANCE IN SPECIALTY FIELDS, MOMENTUM STAFF WILL ENHANCE ENTREPRENEURIAL OUTCOMES THROUGHOUT WV, THUS COUNTERING THE ECONOMIC DISTRESS EVIDENCED BY UNEMPLOYMENT AND PER CAPITA INCOME FIGURES. SPECIFIC ACTIVITIES INCLUDE: 1) COORDINATING WITH ECONOMIC DEVELOPMENT ORGANIZATIONS STATEWIDE, AS WELL AS THE WV ENTREPRENEURSHIP ECOSYSTEM, WHICH BRINGS TOGET

WV WATER QUALITY: BACTERIAL SOURCE TRACKING AND PATHOGEN PROFILING

MATERNAL CONSUMPTION OF OMEGA 3 FATTY ACIDS TO REDUCE BREAST CANCER RISK IN OFFSPRING

THROUGH THIS TECH HUBS STRATEGY DEVELOPMENT AWARD, THE WEST VIRGINIA ADVANCED ENERGY & INDUSTRIAL TECHNOLOGY MANUFACTURING (WV-AEIM) STRATEGY DEVELOPMENT CONSORTIUM WILL DEVELOP THE STRATEGY TO ONSHORE MANUFACTURING AND EMERGING ENERGY TECHNOLOGIES?INCLUDING GRAPHITE MATERIALS, ENERGY STORAGE SOLUTIONS, AND CRITICAL SUPPLY CHAINS ACROSS THE STATE.

THE ROLE OF OXIDATIVE SIGNALING THROUGH NA/K-ATPASE IN PNX-INDUCED ANEMIA - SUMMARY CHRONIC KIDNEY DISEASE (CKD) IS ONE OF THE MOST PROMINENT CONDITIONS AFFECTING APPROXIMATELY 15% OF US ADULTS, AND MOST END-STAGE KIDNEY DISEASE PATIENTS HAVE ANEMIA OF CKD. ALTHOUGH THE CAUSES OF ANEMIA OF CKD ARE MULTIFACTORIAL, PRESENT CLINICAL TREATMENTS COULD ONLY PARTIALLY REVERSE ANEMIA STATUS, INDICATING OTHER MECHANISMS. ACCUMULATING EVIDENCE SUGGESTS THAT ANEMIA IS ALSO THE RESULT OF ACCELERATED ERYPTOSIS THAT SHORTENS RED BLOOD CELL (RBC) LIFESPAN, CONTRIBUTING TO THE DEVELOPMENT AND PROGRESSION OF ANEMIA OF CKD. WE HAVE DEMONSTRATED THAT THE NA/K-ATPASE (NKA) A1 SUBUNIT, BY ITS INTERACTION WITH C- SRC UNDER NATIVE RESTING CONDITION, SERVES AS A “RECEPTOR” FOR REACTIVE OXYGEN SPECIES (ROS) AND ACTS AS A FEED-FORWARD ROS AMPLIFIER. IN A POLE-LIGATION 5/6TH PNX MOUSE MODEL, WE FOUND THAT PNX-INDUCED UREMIC ANEMIA WAS AMELIORATED BY BLOCKING NKA-SRC SIGNALING WITH A SPECIFIC PEPTIDE (PNAKTIDE) BUT NOT WITH THE INDUCTION OF HEMEOXYGENASE-1. PNAKTIDE, WHICH WAS DEVELOPED FROM THE N DOMAIN OF THE NKA A1 SUBUNIT, BINDS TO THE A1-ASSOCIATED C-SRC KINASE DOMAIN TO PREVENT C-SRC PHOSPHORYLATION, ULTIMATELY PREVENTS THE ROS AMPLIFICATION. OUR PRELIMINARY IN VIVO DATA INDICATE THAT PNAKTIDE AMELIORATED PNX-INDUCED ANEMIA BY BLOCKING THE INCREASES IN OXIDATIVE STRESS AND ERYPTOSIS. HOWEVER, THE PNX PROCEDURE, WITH OR WITHOUT PNAKTIDE TREATMENT, DOES NOT SIGNIFICANTLY AFFECT PLASMA IRON HOMEOSTASIS. OUR CENTRAL HYPOTHESIS IS THAT ACCELERATED ERYPTOSIS PLAY A CENTRAL ROLE IN PNX-INDUCED ANEMIA THROUGH STIMULATING NKA-SRC SIGNALING. SPECIFICALLY, WE HYPOTHESIZE THAT PNX- MEDIATED INCREASES IN CARDIOTONIC STEROIDS (CTS), UREMIC TOXINS, AND OXIDATIVE STRESS STIMULATE THE NKA-SRC SIGNALING, WHICH FURTHER INDUCES OXIDATIVE STRESS THAT LEADS TO THE DEVELOPMENT AND PROGRESSION OF ANEMIA. WE FURTHER SUGGEST THAT INHIBITION OF THE NKA-SRC SIGNALING COULD SERVE AS A THERAPY FOR ANEMIA IN CKD. AIM 1 TESTS THE HYPOTHESIS THAT PNX-STIMULATED NKA-SRC SIGNALING INCREASES OXIDATIVE STRESS AND STIMULATES ERYPTOSIS IN VIVO. WE WILL DEFINE THE ROLE OF ADIPOCYTES AND THE GLOBAL NKA- SRC SIGNALING IN THE 5/6TH PNX-INDUCED ANEMIA IN C57/BL6 MICE AND GLOBAL C-SRC KNOCK-OUT MICE. CAVEOLIN-1-NULL MICE AND NKA A1 KNOCKDOWN MICE WILL SERVE AS AN ALTERNATIVE. AIM 2 TESTS THE HYPOTHESIS THAT THE NKA-SRC SIGNALING STIMULATES OXIDATIVE STRESS AND RBC ERYPTOSIS IN ISOLATED RBCS. WE WILL USE ISOLATED RBCS (FROM C57/BL6 AND GLOBAL C-SRC KNOCK-OUT MICE) TO DEFINE THE NKA-SRC SIGNALING COMPLEX IN RBCS UNDER NATIVE RESTING CONDITION. AGAIN, CAVEOLIN-1-NULL MICE AND NKA A1 KNOCKDOWN MICE WILL SERVE AS AN ALTERNATIVE. VALIDATION OF OUR HYPOTHESIS WOULD FURTHER EXPLAIN THE DEVELOPMENT AND PROGRESSION OF ANEMIA UNDER EXCESSIVE OXIDATIVE STRESS SUCH AS HYPERTENSION, AGING, OBESITY, AND DIABETES. IN ADDITION, A CLEARER UNDERSTANDING OF THE MOLECULAR MECHANISMS WOULD HAVE PATHOPHYSIOLOGICAL AND THERAPEUTIC IMPLICATIONS. FURTHER, IT ALSO HAS THE POTENTIAL TO PROVIDE THE FRAMEWORK FOR TRANSLATIONAL CLINICAL RESEARCH TO BOTH TREAT AND PREVENT ANEMIA THAT RESULTS FROM THE NKA-SRC SIGNALING.

THE NA/K-ATPASE RECEPTOR FUNCTION AS A NOVEL THERAPEUTIC TARGET IN MYOCARDIAL INFARCTION

TARGETING ONCOGENIC PATHWAYS FOR CHEMOPREVENTION OF HEAD AND NECK CANCER BY FLLL12 - PROJECT SUMMARY THE DELAY OR PREVENT THE PROGRESSION OF PREMALIGNANT LESIONS TO INVASIVE CANCER BY CHEMOPREVENTION OF SQUAMOUS CELL CARCINOMA OF HEAD AND NECK (SCCHN) IS A DEVASTATING DISEASE WITH SIGNIFICANT MORBIDITY AND MORTALITY. THIS RESEARCH WILL INVESTIGATE THE USE OF FLLL12, A COMPOUND STRUCTURALLY RELATED TO THE NATURAL COMPOUND CURCUMIN, AS A NOVEL COMPOUND FOR CHEMOPREVENTION OF THIS DEADLY CANCER; FLLL12 DEMONSTRATES A CELL SIGNALING PROFILE OF BINDING TO JANUS KINASE (JAK)2 AND INHIBITION OF THE PHOSPHORYLATION OF STAT3. IN ADDITION, FLLL12 INHIBITS EGFR AND AKT TRANSCRIPTS RESULTING IN INHIBITION OF EGFR/AKT-MTOR SIGNALING. THESE SIGNALING PATHWAYS CONFER CELLS WITH THE ABILITY TO ACQUIRE THE ADVANTAGE OF UNLIMITED GROWTH AND RESISTANCE TO CELL DEATH - TWO HALLMARKS OF CARCINOGENESIS. AN EFFECTIVE CHEMOPREVENTION METHOD IMPLEMENTED BEFORE AN INVASIVE CANCER DEVELOPS IS NEEDED TO REDUCE THE INCIDENCE OF SCCHN; HOWEVER, CURRENTLY NO SUCH TREATMENT REGIMEN IS AVAILABLE. THUS, THE IDENTIFICATION OF NEW COMPOUNDS EFFECTIVE IN PREVENTING SCCHN CARCINOGENESIS IS WARRANTED. IN THIS PROPOSAL, WE WILL DEVELOP FLLL12 AS A THERAPEUTIC AGENT FOR THE CHEMOPREVENTION OF SCCHN. OUR PRELIMINARY DATA DEMONSTRATE THAT FLLL12 HAS IC50 VALUES IN A HIGHLY SELECTIVE RANGE (<1 ΜM AGAINST MOST SCCHN CELL LINES AND 0.35 ΜM AGAINST A PREMALIGNANT ORAL CANCER CELL LINE). PHARMACOKINETIC STUDIES REVEAL THAT A PHARMACOLOGICALLY RELEVANT CONCENTRATION IS ACHIEVABLE IN MICE. FLLL12 ALSO EFFECTIVELY INHIBITS TUMOR GROWTH IN A XENOGRAFT MODEL OF SCCHN. THIS PROPOSAL WILL TEST THE ABILITY OF FLLL12 TO PREVENT OR DELAY THE PROGRESSION OF PREMALIGNANT LESIONS TO SCCHN IN A CARCINOGEN-INDUCED ORAL CANCER MODEL IN A MOUSE MODEL AND UNCOVER THE CELL SIGNALING MECHANISM(S) OF ACTION FOR THIS AGENT. WE HYPOTHESIZE THAT FLLL12 REGULATES JAK-STAT3 AND EGFR/AKT-MTOR SURVIVAL PATHWAYS TO REVERSE AND/OR SLOW THE PROGRESSION OF PREMALIGNANT LESIONS TO A SQUAMOUS CELL CANCER. THREE SPECIFIC AIMS ARE PROPOSED. AIM 1: EVALUATE THE JAK-STAT3 PATHWAY AS A DIRECT TARGET OF FLLL12. WE WILL TEST THE PREDICTION THAT FLLL12 INTERACTS WITH JAK2 AND INHIBITS JAK-STAT3 PATHWAY TO MEDIATE THE CHEMOPREVENTION EFFECTS OF THIS COMPOUND. A CELL FREE SYSTEM, IN VITRO KINASE ASSAYS, REPORTER ASSAYS AND A CONSTITUTIVELY ACTIVE STAT3 PLASMID WILL BE USED. AIM 2: DEFINE THE MECHANISM OF REGULATION OF THE EGFR-AKT PATHWAY BY FLLL12. BY EMPLOYING PROMOTER DELETION-MUTATION, WE WILL IDENTIFY TRANSCRIPTION FACTOR(S) THAT INHIBIT EGFR AND AKT TRANSCRIPTS. AIM 3: ANALYZE THE IN VIVO EFFICACY OF FLLL12 AS A CHEMOPREVENTION AGENT IN A CARCINOGEN-INDUCED ORAL CARCINOGENESIS MODEL. A 4NQO-INDUCED ORAL CANCER MOUSE MODEL WILL EVALUATE THE PREVENTION OR DELAY IN ORAL CARCINOGENESIS WITH ADMINISTRATION OF FLLL12. THE OUTCOME OF THE IN VIVO STUDIES WILL CONFIRM THE CHEMOPREVENTION EFFECTS OF FLLL12 IN SCCHN. IMPORTANTLY, THIS R15 AWARD WILL PROVIDE A STIMULATING TRAINING OPPORTUNITY FOR UNDERGRADUATE AND GRADUATE STUDENTS TO PARTICIPATE ACTIVELY IN THE RESEARCH AND DISCOVERY PROCESS TO IMPROVE OUR UNDERSTANDING OF THE SIGNAL TRANSDUCTION PATHWAYS INVOLVED IN CANCER BIOLOGY.

INVESTIGATING SEX DIFFERENCES IN ASTROCYTE-MEDIATED SYNAPTIC DEVELOPMENT - REGULATION OF SYNAPTIC CONNECTIVITY BY ASTROCYTES IS CRITICAL FOR DEVELOPMENT OF THE CENTRAL NERVOUS SYSTEM (CNS), YET LITTLE IS KNOWN ABOUT HOW THESE PROCESSES DIFFER BETWEEN MALES AND FEMALES. THE LONG-TERM GOAL IS TO IDENTIFY MECHANISMS INVOLVED IN ASTROCYTE-MEDIATED SYNAPTIC DEVELOPMENT IN ORDER TO INFORM NOVEL THERAPIES TO PREVENT OR CORRECT DISRUPTED SYNAPTIC CIRCUITRY IN NEURODEVELOPMENTAL DISEASES IN PATIENTS OF BOTH SEXES. THE PRIMARY OBJECTIVE OF THIS APPLICATION IS TO INVESTIGATE BASIC FUNDAMENTAL DIFFERENCES IN ASTROCYTE-NEURON SYNAPTOGENIC SIGNALING BETWEEN MALES AND FEMALES. THE CENTRAL HYPOTHESIS IS THAT THROMBOSPONDIN (TSP)- INDUCED SYNAPTOGENESIS IS REQUIRED FOR PROPER CORTICAL DEVELOPMENT OF MALES BUT LESS ESSENTIAL FOR FEMALES, ESTABLISHING SEXUAL DIMORPHISM IN ASTROCYTE-MEDIATED SYNAPTIC DEVELOPMENT. THE CENTRAL HYPOTHESIS WILL BE TESTED IN THREE SPECIFIC AIMS: 1) EVALUATE SEX DIFFERENCES IN ASTROCYTE SYNAPTOGENIC SIGNALING; 2) ELUCIDATE THE MOLECULAR MECHANISM UNDERLYING SEX DIFFERENCES IN TSP-INDUCED SYNAPTOGENESIS; AND 3) INVESTIGATE SEX-DEPENDENT REGULATION OF DENDRITIC SPINE AND SYNAPSE DEVELOPMENT BY THE TSP RECEPTOR, A2D-1. IN THE FIRST AIM, ASTROCYTE-CONDITIONED MEDIA (CONTAINING SECRETED FACTORS) FROM EITHER MALE OR FEMALE RATS WILL BE EVALUATED FOR THEIR SYNAPTOGENIC EFFICACY ON NEURONS DERIVED FROM EITHER SEX. THE IMPACT OF ASTROCYTIC ESTROGEN RECEPTORS AS WELL AS NEURON-SECRETED FACTORS ON EXPRESSION AND SECRETION OF VARIOUS ASTROCYTIC SYNAPTOGENIC FACTORS WILL ALSO BE DETERMINED. FOR THE SECOND AIM, ESTROGEN SIGNALING IN TSP- TREATED CORTICAL NEURON CULTURES WILL BE MANIPULATED TO DELINEATE THE CONTRIBUTIONS OF BRAIN- DERIVED NEUROTROPHIC FACTOR (BDNF), RAC1, AND PRESYNAPTIC MUTING ON ASTROCYTE SYNAPTOGENIC SIGNALING. IN THE THIRD AIM, MALE AND FEMALE IN VIVO AND EX VIVO MODELS WILL BE ASSESSED FOR DENDRITIC SPINE SYNAPTIC DEVELOPMENT IN A TRANSGENIC MOUSE LINE LACKING THE TSP SYNAPTOGENIC RECEPTOR, A2D-1, IN THE CORTEX. THIS RESEARCH APPROACH IS INNOVATIVE BECAUSE IT WILL RIGOROUSLY EXPLORE THE NOVEL POSSIBILITY THAT ASTROCYTE-MEDIATED SYNAPTIC DEVELOPMENT IS DIFFERENTIALLY REGULATED BETWEEN MALES AND FEMALES AND IDENTIFY ESTROGEN AS A PROMINENT REGULATORY ELEMENT IN THIS PROCESS. THE RESEARCH PROPOSED IN THIS APPLICATION IS SIGNIFICANT BECAUSE IT WILL PROVIDE THE BASIS FOR INCREASINGLY ROBUST EXPERIMENTAL DESIGNS INTENDED TO ELUCIDATE NOVEL MECHANISMS OF SYNAPTOGENESIS AND ASTROCYTE/NEURONAL CROSSTALK IN BOTH SEXES. INVESTIGATING SEX DIFFERENCES IN ASTROCYTE SIGNALING WILL EXPAND OUR UNDERSTANDING OF SYNAPTIC NETWORK FORMATION IN BOTH MALES AND FEMALES IN ORDER TO GENERATE INNOVATIVE STRATEGIES TO IDENTIFY, PREVENT, OR CORRECT ABERRANT SYNAPTIC CONNECTIVITY IN DEVELOPMENTAL CNS DISORDERS SUCH AS AUTISM AND SCHIZOPHRENIA.

THE ROLE OF OXIDATIVE SIGNALING THROUGH NA/K-ATPASE IN SALT-SENSITIVE HYPERTENSION

PHENOTYPIC PLASTICITY ASSOCIATED WITH INHIBITION OF HSP90

IMPACT OF PRENATAL OR ADULT EXPOSURE TO METHAMPHETAMINE ON THE ISCHEMIC HEART

IDENTIFICATION OF DIABETES SUSCEPTIBILITY GENES VIA AN INTEGRATED FUNCTIONAL GENOMICS ANALYSIS OF GENE-DIET INTERACTION

DEVELOPMENTAL SYSTEMS, RUI: POLARIZING A CELL LAYER ALONG TWO AXES

DISCOVERY OF GENETIC AND GENOMIC MECHANISMS DRIVING THE RELATIONSHIP BETWEEN SOCIAL REWARD AND COCAINE ADDICTION - PROJECT ABSTRACT DRUG ADDICTION IS A CRITICAL PUBLIC HEALTH CRISIS THAT IS STRONGLY GENETICALLY DRIVEN. A FUNDAMENTAL DRIVER OF HUMAN ADDICTION IS THE REPEATED CHOICE TO PURSUE A DRUG REWARD AT THE EXPENSE OF A SOCIAL REWARD, A STRONG REINFORCER OF HUMAN BEHAVIOR IN NON-ADDICTED INDIVIDUALS. DESPITE THE IMPORTANCE OF THIS PHENOMENON IN HUMAN ADDICTION, THE GENETIC MECHANISMS UNDERLYING VARIATION IN THE PREFERENCE FOR A SOCIAL REWARD OVER A DRUG REWARD (HENCEFORTH SOCIAL REWARD PREFERENCE) HAVE BEEN TOTALLY UNEXPLORED BECAUSE OF THE ABSENCE OF A RELEVANT MOUSE MODEL. ESTABLISHING A MOUSE MODEL OF SOCIAL REWARD PREFERENCE WOULD ENABLE LEVERAGING THE VAST MOUSE GENETICS TOOLKIT FOR DISCOVERY AND CHARACTERIZATION OF THE MECHANISMS DRIVING THIS TRAIT, WHICH, AT ITS EXTREMES, REPRESENTS VULNERABILITY TO AND RESISTANCE TO A KEY ADDICTION VECTOR. TO THIS END, WE PROPOSE TO HARNESS THE UNPRECEDENTED GENETIC DIVERSITY OF ADVANCED MOUSE POPULATIONS AND THE EXCEPTIONAL CONSTRUCT- VALIDITY OF THE INTRAVENOUS COCAINE SELF-ADMINISTRATION PARADIGM TO DISCOVER GENETIC AND GENOMIC MECHANISMS DRIVING SOCIAL REWARD PREFERENCE. TO QUANTIFY SOCIAL REWARD PREFERENCE IN THE MOUSE, WE WILL USE A RECENTLY INTRODUCED PARADIGM FOR THE RAT IN WHICH THE SUBJECT MAKES A BINARY CHOICE TO (1) INTRAVENOUSLY SELF-ADMINISTER AN ADDICTIVE DRUG OR (2) BRIEFLY INTERACT WITH A CONSPECIFIC. TO CAPTURE MAXIMUM PHENOTYPIC VARIATION AND ENABLE DISCOVERY OF GENETIC MECHANISMS DRIVING SOCIAL REWARD PREFERENCE, WE WILL USE MICE FROM THE COLLABORATIVE CROSS (CC) MOUSE PANEL WHICH CONTAINS 90% OF THE GENETIC DIVERSITY IN THE MOUSE SPECIES AND ENABLES THE INTEGRATION OF GENOMIC AND PHENOMIC DATASETS ACROSS STUDIES. IN AIM 1 WE WILL QUANTIFY THE PREFERENCE FOR SOCIAL REWARD RELATIVE TO COCAINE REWARD IN MALE AND FEMALE MICE FROM EIGHT CC STRAINS. WE WILL QUANTIFY HERITABILITY OF THESE PHENOTYPES AND IDENTIFY STRAINS EXHIBITING VULNERABILITY AND RESISTANCE TO SOCIAL REWARD PREFERENCE PHENOTYPES (E.G., STRONG PREFERENCE FOR A COCAINE REWARD RELATIVE TO A SOCIAL REWARD, AND VICE VERSA). IN AIM 2 WE WILL QUANTIFY GENE EXPRESSION IN THE NUCLEUS ACCUMBENS FOLLOWING OPERANT SELF- ADMINISTRATION OF A SOCIAL REWARD, YOKED EXPOSURE TO A SOCIAL REWARD, AND SHAM EXPOSURE TO A SOCIAL REWARD IN MICE FROM THE SAME EIGHT CC STRAINS USED IN AIM 1. WE WILL PERFORM RNA-SEQ IN EIGHT CC STRAINS AND SCRNA- SEQ IN TWO EXTREME CC STRAINS. WE WILL INTEGRATE GENE EXPRESSION DATA (AIM 2) WITH BEHAVIORAL DATA (AIM 1) TO IDENTIFY CELL-TYPE SPECIFIC GENE EXPRESSION SIGNATURES PREDICTIVE OF SOCIAL REWARD PREFERENCE. THE SUCCESSFUL COMPLETION OF THESE AIMS WILL PROVIDE (1) A FOUNDATION FOR FUTURE DEEP CHARACTERIZATION OF IDENTIFIED MECHANISMS UNDERLYING SOCIAL REWARD PREFERENCE IN MICE; (2) A LASTING COMMUNITY RESOURCE ENABLING GENETIC CORRELATIONAL ANALYSIS AMONG A SUBSET OF THE CC STRAINS ACROSS PHENOTYPES, EXPERIMENTS, AND LABORATORIES; AND (3) A REFINED AND ROBUST PIPELINE FOR FUTURE CHARACTERIZATION OF SOCIAL REWARD PREFERENCE IN THE FULL PANEL OF 60 CC STRAINS. ULTIMATELY, THIS WORK WILL CONTRIBUTE TO THE DEVELOPMENT OF NOVEL, MORE EFFECTIVE ADDICTION TREATMENTS.

HEALTH PROMOTION/DISEASE PREVENTION

ACQUISITION OF A FIELD EMISSION SCANNING ELECTRON MICROSCOPE FOR RESEARCH AND TEACHING IN THE FIELDS OF CHEMISTRY, GEOLOGY, BIOLOGY, PHYSICS, AND FORENSIC SCIENCE

ADVANCING STEM LEARNING AND INSTITUTIONAL CHANGE THROUGH FACULTY TRAINING, RESOURCES, AND SUPPORT TO ADOPT EVIDENCE-BASED INSTRUCTIONAL STRATEGIES -THIS PROJECT AIMS TO SERVE THE NATIONAL INTEREST BY IMPLEMENTING EVIDENCE-BASED INSTRUCTIONAL PRACTICES IN UNDERGRADUATE STEM COURSES TO IMPROVE STUDENT OUTCOMES, PERSISTENCE, AND RETENTION?PARTICULARLY FOR THE APPALACHIAN REGION. THE PROJECT INTENDS TO INCREASE FACULTY CAPACITY TO DELIVER ENGAGING INSTRUCTION BY TRAINING SCIENCE AND ENGINEERING FACULTY IN ACTIVE LEARNING STRATEGIES AND OTHER EVIDENCE-BASED PEDAGOGIES AND ASSESSMENT TECHNIQUES. THE SIGNIFICANCE OF THIS PROJECT LIES IN ITS FOCUS ON HIGH-ENROLLMENT STEM COURSES WITH ELEVATED D/F/W RATES THAT SERVE LARGE NUMBERS OF FIRST-GENERATION COLLEGE STUDENTS, TRANSFER STUDENTS, AND STUDENTS FROM RURAL BACKGROUNDS. BY EQUIPPING FACULTY WITH RESEARCH-BASED INSTRUCTIONAL TOOLS AND FOSTERING A SUSTAINABLE PROFESSIONAL LEARNING COMMUNITY, THE PROJECT SUPPORTS STUDENT SUCCESS IN FOUNDATIONAL STEM COURSES AND CONTRIBUTES TO BUILDING A SKILLED WORKFORCE THAT MEETS BOTH REGIONAL AND NATIONAL NEEDS. THIS LEVEL 1 INSTITUTIONAL AND COMMUNITY TRANSFORMATION PROJECT INCLUDES A STRUCTURED PROFESSIONAL DEVELOPMENT PROGRAM, THE USE OF MOBILE SUMMER INSTITUTES (MOSI), COMPETITIVE MINIGRANTS THAT PROVIDE FACULTY WITH RESOURCES TO IMPLEMENT COURSE INNOVATIONS, AND THE CREATION OF COMMUNITIES OF PRACTICE (COP) TO CULTIVATE FACULTY COLLABORATION, PEER LEARNING, AND INSTITUTIONAL CULTURE CHANGE AROUND STEM INSTRUCTION. THE PROJECT IS EXPECTED TO LEAD TO SUSTAINED IMPROVEMENTS IN UNDERGRADUATE STEM EDUCATION THROUGH ENHANCEMENTS IN TEACHING EFFECTIVENESS, STUDENT ENGAGEMENT, AND INSTITUTIONAL POLICIES RELATED TO FACULTY RECOGNITION AND REWARD SYSTEMS. THE PROJECT GOALS ARE TO INCREASE FACULTY ADOPTION OF EVIDENCE-BASED TEACHING, IMPROVE INSTRUCTIONAL EFFECTIVENESS, AND ADVANCE UNDERSTANDING OF INSTITUTIONAL FACTORS THAT SUSTAIN PEDAGOGICAL CHANGE. THE SCOPE INCLUDES TWO MOSI IN PARTNERSHIP WITH THE NATIONAL INSTITUTE ON SCIENTIFIC TEACHING?TRAINING 35 FACULTY ACROSS DISCIPLINES IN THE COLLEGE OF SCIENCE AND COLLEGE OF ENGINEERING IN EVIDENCE-BASED INSTRUCTIONAL PRACTICES, ESPECIALLY ACTIVE LEARNING. FACULTY WILL DESIGN ACTIVE LEARNING MATERIALS, IMPLEMENT THEM IN HIGH-IMPACT STEM COURSES, AND PARTICIPATE IN COP SUPPORTED BY THE UNIVERSITY'S CENTER FOR TEACHING AND LEARNING. THESE EFFORTS WILL BE REINFORCED THROUGH MINIGRANTS, PEER MENTORING, AND INSTITUTIONAL INCENTIVES SUCH AS COURSE DESIGNATIONS AND RECOGNITION IN PROMOTION AND TENURE PROCESSES. EVALUATION METHODS INCLUDE PRE/POST FACULTY SURVEYS, STUDENT FEEDBACK, AND COURSE PERFORMANCE DATA, WITH OVERSIGHT BY AN EXTERNAL EVALUATOR. THE PROJECT'S THEORY OF CHANGE IS BASED ON A PATH MODEL WHICH EMPHASIZES THE DYNAMIC INTERACTION BETWEEN INDIVIDUAL MOTIVATION, FACULTY DEVELOPMENT OPPORTUNITIES, AND INSTITUTIONAL SUPPORTS. BY STARTING WITH MOTIVATED FACULTY AND ADMINISTRATORS, THE PROJECT AIMS TO CREATE A POSITIVE FEEDBACK LOOP WHERE INCREASED KNOWLEDGE AND INSTRUCTIONAL REFORM CATALYZE SHIFTS IN CULTURE AND POLICY THAT REINFORCE LONG-TERM ADOPTION OF ACTIVE LEARNING. THE PROJECT PLANS TO STUDY THE EFFECTIVENESS OF FACULTY DEVELOPMENT MODELS, INVESTIGATE THE CONDITIONS UNDER WHICH INSTRUCTIONAL CHANGES IMPROVE STUDENT OUTCOMES, AND CONTRIBUTE NEW KNOWLEDGE ABOUT MECHANISMS AND INSTITUTIONAL CONDITIONS THAT SUPPORT SUSTAINED ADOPTION OF ACTIVE LEARNING IN UNDERGRADUATE STEM EDUCATION. RESULTS WILL BE DISSEMINATED LOCALLY AND NATIONALLY THROUGH WORKSHOPS, CONFERENCES, AND PUBLICATIONS. THE NSF IUSE: EDU PROGRAM SUPPORTS RESEARCH AND DEVELOPMENT PROJECTS TO IMPROVE THE EFFECTIVENESS OF STEM EDUCATION FOR ALL STUDENTS. THROUGH THE INSTITUTIONAL AND COMMUNITY TRANSFORMATION TRACK, THE PROJECT SUPPORTS EFFORTS TO TRANSFORM AND IMPROVE STEM EDUCATION ACROSS INSTITUTIONS OF HIGHER EDUCATION AND DISCIPLINARY COMMUNITIES. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

FUND FOR THE IMPROVEMENT OF POSTSECONDARY EDUCATION - EUROPEAN EXCHANGE

ROLE OF ADIPOCYTE NA/K-ATPASE SIGNALING IN THE DEVELOPMENT AND PROGRESSION OF UREMIC CARDIOMYOPATHY BY ALTERING ADIPOCYTE PHENOTYPE

DISCOVERY OF DISULFIRAM AS AN ANTI-MRSA ANTIBIOTIC ADJUVANT

EFFECTS OF ADOLESCENT ETHANOL EXPOSURE ON ASTROCYTE-NEURONAL CROSSTALK - ABSTRACT ADOLESCENT BINGE DRINKING PROMOTES ENDURING COGNITIVE DEFICITS AND HIGHER INCIDENCE OF ALCOHOL USE DISORDER IN ADULTHOOD. STUDIES USING A RAT MODEL OF ADOLESCENT BINGE DRINKING (ETOH) DEMONSTRATE LONG-TERM DEFICITS IN HIPPOCAMPAL NEURONAL STRUCTURE, FUNCTION, AND BEHAVIOR; HOWEVER, THE UNDERLYING MECHANISMS ARE NOT WELL UNDERSTOOD. COINCIDENT WITH CHANGES IN CA1 HIPPOCAMPAL NEURONAL CIRCUIT FUNCTION, ADOLESCENT ETOH EXPOSURE RESULTS IN ASTROCYTE REACTIVITY AND CHRONIC DYSREGULATION OF ASTROCYTE-SECRETED SIGNALING FACTORS KNOWN TO BE INVOLVED IN SYNAPTIC REMODELING. ASTROCYTES TIGHTLY REGULATE SYNAPTIC ACTIVITY AND ION HOMEOSTASIS THROUGH THEIR PERISYNAPTIC ASTROCYTE PROCESSES (PAPS), ALLOWING FOR BI-DIRECTIONAL COMMUNICATION THROUGH VARIOUS CONTACT- MEDIATED AND SECRETED SIGNALING FACTORS THAT MODULATE SYNAPTIC TRANSMISSION. IN ADDITION, THE BEHAVIORAL RELEVANCE OF ASTROCYTE/SYNAPTIC COMMUNICATION IS BEGINNING TO EMERGE THROUGH EXCITING NEW ADVANCES SHOWING ASTROCYTES TO BE INVOLVED IN BEHAVIORAL RESILIENCY, FEAR LEARNING, AND REMOTE MEMORY, AND CONTRIBUTE TO WORKING MEMORY DEFICITS FOLLOWING DRUG EXPOSURE. CURRENT DATA DEMONSTRATES THAT ETOH-INDUCED PERSISTENCE OF IMMATURE DENDRITIC SPINES (I.E. SITES OF EXCITATORY SYNAPTIC INPUT) IS SPATIOTEMPORALLY LINKED WITH PAP-SYNAPTIC DECOUPLING. BASED ON PRELIMINARY DATA THE RESEARCHERS PREDICT THAT DISRUPTION OF PAP PROXIMITY TO SYNAPSES COMPROMISES NEURON-TO-ASTROCYTE SIGNALING AND THE ABILITY OF ASTROCYTES TO REGULATE SYNAPTIC HOMEOSTASIS. THEREFORE, THE OVERALL OBJECTIVE OF THIS APPLICATION IS TO ELUCIDATE HOW ETOH-INDUCED DISRUPTION OF PAP-SYNAPTIC COUPLING AND NEURON-ASTROCYTE CROSSTALK CONTRIBUTES TO LONG-TERM CHANGES IN SYNAPTIC FUNCTION. ACHIEVING THIS OBJECTIVE WILL ALLOW THE RESEARCHERS TO REACH THEIR LONG-TERM GOAL, WHICH IS TO IDENTIFY THE CELLULAR AND MOLECULAR MECHANISMS THAT MAY INFORM NOVEL TREATMENTS FOR THE PREVENTION AND REVERSAL OF SYNAPTIC DYSFUNCTION AND THE EMERGENCE OF AUD AFTER REPEATED ADOLESCENT ETOH EXPOSURE. THE CENTRAL HYPOTHESIS IS THAT REPEATED ADOLESCENT ETOH EXPOSURE TRIGGERS PAP-SYNAPTIC DECOUPLING AND LASTING CHANGES IN ASTROCYTE-NEURONAL CROSSTALK. THE RATIONALE BEHIND THE PROJECT IS THAT UNDERSTANDING THE NOVEL MEDIATORS THAT DRIVE ETOH-INDUCED MALADAPTIVE ASTROCYTE-NEURONAL CROSSTALK WILL CONTRIBUTE KEY INSIGHT INTO THE MECHANISMS UNDERLYING SYNAPTIC DYSFUNCTION FOLLOWING ADOLESCENT ETOH EXPOSURE. THE PROPOSED RESEARCH IS SIGNIFICANT SINCE SUCCESSFUL COMPLETION WILL RESULT IN THE IDENTIFICATION OF NON-NEURONAL PROCESSES CRITICAL FOR THE PREVENTION AND REVERSAL OF NEURONAL CIRCUIT DYSFUNCTION FOLLOWING ADOLESCENT ETHANOL EXPOSURE. AN INTERDISCIPLINARY TEAM OF INVESTIGATORS AND CONSULTANTS WITH EXPERTISE IN THE FIELD OF ADOLESCENT ALCOHOL, ASTROCYTES, AND ELECTROPHYSIOLOGY WILL CONDUCT THIS INNOVATIVE PROJECT.

REU SITE: UNDERGRADUATE RESEARCH IN DATA ANALYTICS (REU:URDA) -THIS AWARD SUPPORTS THE CREATION OF A NEW REU SITE AT MARSHALL UNIVERSITY FOCUSED ON DATA SCIENCE. OVER A SUMMER SESSION, 30 UNDERGRADUATE STUDENTS FROM DIVERSE BACKGROUNDS?INCLUDING FIRST-GENERATION, FEMALE, AND UNDERREPRESENTED MINORITY STUDENTS AND THOSE FROM ECONOMICALLY DISADVANTAGED APPALACHIAN REGIONS?WILL ENGAGE IN TRANSFORMATIVE RESEARCH EXPERIENCES. THIS PROGRAM ADDRESSES THE GROWING DEMAND FOR SKILLED DATA SCIENTISTS IN THE U.S. WORKFORCE BY PROVIDING PRACTICAL EXPERIENCE IN DATA ANALYTICS (VISUAL, DESCRIPTIVE, AND PREDICTIVE), EQUIPPING PARTICIPANTS WITH THE SKILLS NEEDED TO SUCCEED ACADEMICALLY AND PROFESSIONALLY. THE PROJECT CONTRIBUTES TO NATIONAL INTERESTS BY CREATING A MORE DIVERSE AND INCLUSIVE DATA SCIENCE WORKFORCE, INCREASING EDUCATIONAL OPPORTUNITIES FOR STUDENTS FROM LOW-INCOME INSTITUTIONS, AND SUPPORTING THE PROFESSIONAL DEVELOPMENT OF YOUNG RESEARCHERS IN STEM FIELDS. THIS THREE-YEAR REU SITE AT MARSHALL UNIVERSITY WILL EXPLORE VARIOUS DATA ANALYTICS TOPICS, INCLUDING CYBERSECURITY, INTERNET OF THINGS (IOT), SOCIAL MEDIA ANALYTICS, AND LARGE-SCALE DATA CENTER PERFORMANCE ANALYSIS. THE PROJECT OBJECTIVES ARE TO (1) ENHANCE DIVERSITY IN STEM BY ENCOURAGING WOMEN, UNDERREPRESENTED MINORITIES, VETERANS, AND FIRST-GENERATION STUDENTS TO PURSUE DEGREES AND CAREERS IN DATA SCIENCE; (2) TRAIN PARTICIPANTS IN ANALYTIC METHODS, LINKING CLASSROOM KNOWLEDGE TO REAL-WORLD APPLICATIONS; (3) CULTIVATE PARTICIPANTS' RESEARCH CREATIVITY; AND (4) PROVIDE COMPREHENSIVE MENTORING WORKSHOPS AND PROFESSIONAL TRAINING TO SUPPORT STUDENT SUCCESS. THIS PROJECT WILL SIGNIFICANTLY ADVANCE DATA SCIENCE RESEARCH AND EDUCATION, PARTICULARLY IN UNDERREPRESENTED AREAS, SERVING AS A MODEL FOR INTEGRATING RESEARCH AND EDUCATION TO SUPPORT NATIONAL WORKFORCE DEVELOPMENT GOALS. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

WATER POLLUTANTS, WV PROJECT AT MARSHALL UNIVERSITY

HEAT ENHANCED MOLECULAR DELIVERY TO GROWTH PLATES FOR TARGETED BONE LENGTHENING

ADDICTION MEDICINE FELLOWSHIP - PROJECT ABSTRACT 1600 MEDICAL CENTER DRIVE | HUNTINGTON, WV 25701 PROJECT DIRECTOR: DR. JAMES BECKER BECKER1@MARSHALL.EDU 304-691-1700 GRANT REQUEST: $1,919,481 THE MARSHALL UNIVERSITY JOAN C. EDWARDS SCHOOL OF MEDICINE (MUSOM) PROPOSES AN ADDICTION MEDICINE FELLOWSHIP PROGRAM TO ADDRESS THE CRITICAL NEED FOR SPECIALIZED TRAINING IN ADDICTION MEDICINE. THIS PROGRAM AIMS TO EQUIP FAMILY DOCTORS WITH THE EXPERTISE REQUIRED TO OBTAIN BOARD CERTIFICATION IN ADDICTION MEDICINE THROUGH THE AMERICAN BOARD OF PREVENTIVE MEDICINE. THE PROGRAM IS DESIGNED TO SERVE UNDERSERVED RURAL AND SMALL-TOWN COMMUNITIES IN CENTRAL APPALACHIA, PARTICULARLY IN WEST VIRGINIA, WHICH HAS BEEN SEVERELY IMPACTED BY SUBSTANCE USE DISORDERS (SUD), ESPECIALLY OPIOID USE DISORDER (OUD) AND OPIOID OVERDOSE DEATHS. NEEDS TO ADDRESS: WEST VIRGINIA FACES NUMEROUS CHALLENGES, INCLUDING A DECLINING POPULATION, LOW MEDIAN HOUSEHOLD INCOME, HIGH POVERTY RATES, AND SIGNIFICANT SOCIAL ISSUES EXACERBATED BY THE COVID-19 PANDEMIC. THE STATE HAS THE HIGHEST OVERDOSE DEATH RATE IN THE NATION, WITH SIGNIFICANT GAPS IN ACCESS, SUPPLY, QUALITY, AND DISTRIBUTION OF SUD SERVICES, PARTICULARLY IN RURAL AREAS. THE PROGRAM AIMS TO ADDRESS THESE CHALLENGES BY INCREASING THE NUMBER OF TRAINED ADDICTION MEDICINE SPECIALISTS, ENHANCING COMMUNITY AWARENESS, AND PROMOTING EVIDENCE-BASED PRACTICES. PROPOSED SERVICES: THE ADDICTION MEDICINE FELLOWSHIP PROGRAM WILL PROVIDE COMPREHENSIVE TRAINING TO FELLOWS, INCLUDING INPATIENT AND OUTPATIENT EXPERIENCES, COMMUNITY COLLABORATION, AND RESEARCH OPPORTUNITIES. THE PROGRAM WILL FOCUS ON: • INCREASING SERVICE CAPACITY BY TRAINING MORE ADDICTION MEDICINE SPECIALISTS. • ENHANCING COMMUNITY AWARENESS ABOUT SUD AND REDUCING STIGMA. • DEVELOPING EXPERTISE IN ADDICTION MEDICINE, INCLUDING MEDICAL, BEHAVIORAL, AND SOCIAL ASPECTS. • PROMOTING EVIDENCE-BASED PRACTICES IN ADDICTION TREATMENT. • SUPPORTING COMMUNITY COLLABORATION WITH HEALTHCARE PROVIDERS, SOCIAL SERVICES, DRUG COURTS, AND LAW ENFORCEMENT. POPULATION GROUPS TO SERVE: THE PROGRAM WILL PRIMARILY SERVE UNDERSERVED RURAL AND SMALL-TOWN COMMUNITIES IN CENTRAL APPALACHIA, FOCUSING ON WEST VIRGINIA. THESE COMMUNITIES OFTEN LACK THE NECESSARY INFRASTRUCTURE, RESOURCES, AND WORKFORCE TO ADDRESS THE SUD EPIDEMIC EFFECTIVELY. THE PROGRAM WILL ALSO TARGET POPULATIONS WITH HIGH RATES OF SUBSTANCE USE AND MENTAL HEALTH ISSUES, INCLUDING THOSE EXPERIENCING HOMELESSNESS AND INDIVIDUALS INVOLVED IN THE CRIMINAL JUSTICE SYSTEM. FUNDING PRIORITIES: 1. TEAM-BASED CARE: THE PROGRAM HAS AND WILL CONTINUE IMPLEMENTING INTEGRATED, INTERPROFESSIONAL, TEAM-BASED CARE MODELS FOCUSED ON AT-RISK POPULATIONS FOR OUD AND OTHER SUD PREVENTION, TREATMENT, AND RECOVERY SERVICES. 2. HEALTH INFORMATION TECHNOLOGY: THE PROGRAM HAS AND WILL CONTINUE TO UTILIZE TELEHEALTH SERVICES TO EXTEND THE REACH OF ADDICTION TREATMENT AND SUPPORT TO REMOTE AND RURAL COMMUNITIES, ENHANCING FELLOWS' LEARNING ABOUT WORKING IN A TELEHEALTH ENVIRONMENT. 3. RURAL AND UNDERSERVED COMMUNITIES: THE PROGRAM HAS AND WILL CONTINUE COLLABORATING WITH MEDICALLY UNDERSERVED COMMUNITY-BASED SITES, INCLUDING THOSE IN RURAL AREAS, TO ENSURE ADEQUATE SUPERVISION AND LOGISTICAL SUPPORT FOR FELLOWSHIP ROTATIONS. FUNDING PREFERENCES: THE PROGRAM REQUESTS FUNDING PREFERENCES FOR SERVING IN MEDICALLY UNDERSERVED COMMUNITIES (MUC) AND AS A NEW TRAINING PROGRAM. THE PROGRAM'S COMMITMENT TO ADDRESSING THE CRITICAL NEED FOR ADDICTION MEDICINE SPECIALISTS IN RURAL AND UNDERSERVED AREAS ALIGNS WITH HRSA'S GOALS OF IMPROVING HEALTHCARE ACCESS AND OUTCOMES FOR VULNERABLE POPULATIONS. BY ADDRESSING THESE NEEDS AND IMPLEMENTING THESE SERVICES, THE MARSHALL UNIVERSITY SCHOOL OF MEDICINE ADDICTION MEDICINE FELLOWSHIP PROGRAM AIMS TO SIGNIFICANTLY INCREASE THE NUMBER OF PHYSICIANS WORKING IN ADDICTION MEDICINE, HELP REDUCE THE STIGMA, AND IMPACT THE HEALTH AND WELL-BEING OF INDIVIDUALS AND COMMUNITIES AFFECTED BY SUBSTANCE USE DISORDERS.

ALPHA4ALPHA6 NICOTINIC RECEPTORS: BIOMARKERS FOR NICOTINE ADDICTION

THIS EDA INVESTMENT SUPPORTS THE MARSHALL UNIVERSITY RESEARCH CORPORATION WITH THE OPERATIONS OF THE HEARTLAND INTERMODAL GATEWAY FACILITY THOUGH THE PROCUREMENT OF ANCHOR TENANT(S) TO HELP SERVICE A COMMUNITY IMPACTED BY THE DECLINING USE OF COAL IN HUNTINGTON, WEST VIRGINIA. ONCE COMPLETED, THE PROJECT WILL HELP THE REGION CREATE NEW JOB OPPORTUNITIES TO BOOST ECONOMIC DEVELOPMENT, DIVERSIFY THE LOCAL ECONOMY, AND ADVANCE ECONOMIC RESILIENCY.

THE PREVENTION EMPOWERMENT PARTNERSHIP

CSBR: NATURAL HISTORY COLLECTIONS: RUI: COLLECTION IMPROVEMENT OF MARSHALL UNIVERSITY'S WV VERTEBRATE SURVEY MUSEUM: WEST VIRGINIA NATURAL HISTORY

REU SITE: APPALACHIAN MATHEMATICS AND PHYSICS SITE -THE DEPARTMENT OF MATHEMATICS AND PHYSICS AT MARSHALL UNIVERSITY WILL HOST AN EIGHT-WEEK REU SITE DURING SUMMERS 2024 THROUGH 2026. THE PROGRAM HAS FIVE MAIN OBJECTIVES: HALF OF PARTICIPANTS WILL ATTEND UNIVERSITY IN THE APPALACHIAN REGION, PARTICIPANTS WILL OBTAIN USEFUL SKILLS IN COMMUNICATING AND COLLABORATING ON MATHEMATICS AND PHYSICS PROJECTS, THE PROGRAM WILL PRODUCE HIGH QUALITY RESEARCH ON A VARIETY OF MATHEMATICS AND PHYSICS TOPICS, PARTICIPANTS WILL ACHIEVE GAINFUL EMPLOYMENT IN A STEM-ADJACENT CAREER OR ATTEND GRADUATE SCHOOL, AND AT LEAST 40% OF PARTICIPANTS WILL ATTEND GRADUATE SCHOOL OR WORK IN THE APPALACHIAN REGION. FUNDING WILL BE USED TO SUPPORT AN UNDERGRADUATE RESEARCH CONFERENCE IN CONJUNCTION WITH OTHER EXISTING SUMMER RESEARCH ACTIVITIES AT MARSHALL UNIVERSITY, AND PARTICIPANTS IN THIS PROGRAM WILL ATTEND AND PRESENT THEIR WORK. EACH SUMMER, A COHORT OF TEN UNDERGRADUATE STUDENTS WILL BE FUNDED TO WORK AND LIVE ON THE CAMPUS OF MARSHALL UNIVERSITY IN HUNTINGTON, WV FOR EIGHT WEEKS. DURING THE FIRST WEEK, ORIENTATION ACTIVITIES WILL COMMENCE, INCLUDING A DISCUSSION ON RESEARCH ETHICS, INTRODUCTIONS TO PROJECTS, AND FORMALIZING RESEARCH GROUPS. THE SLATE OF PROJECTS FOR THE YEAR WILL BE INTRODUCED TO STUDENTS AT THIS TIME WITH A VARIETY OF PROJECTS ACROSS MATHEMATICS AND PHYSICS, INCLUDING, BUT NOT LIMITED TO, COMPUTATIONAL PROJECTS ON MULTI-MESSENGER ASTROPHYSICS AND INVERSE SCATTERING, LABORATORY RESEARCH ON FILTRATION OF TEXTILE DYES, AND PURE MATHEMATICAL PROJECTS IN COMPLEX ANALYSIS AND SPECIAL FUNCTIONS THEORY. DURING WEEKS TWO THROUGH SEVEN, PARTICIPANTS WILL BE WORKING FULL TIME ON THEIR RESEARCH, REGULARLY SEE PRESENTATIONS BY SPEAKERS INVITED BY THE REU ORGANIZERS, AND REGULARLY GIVE PRESENTATIONS ON THEIR RESEARCH TO PEERS. IN THE FINAL WEEK, ATTENDANCE AT THE NEW SUMMER UNDERGRADUATE RESEARCH CONFERENCE AND FINAL WRITEUPS OF RESEARCH WILL OCCUR. THE AMPS PROGRAM WEBPAGE WILL BE HOSTED AT HTTP://AMPS.MARSHALL.EDU/. THIS PROJECT IS JOINTLY FUNDED BY THE MATHEMATICAL SCIENCES RESEARCH EXPERIENCES FOR UNDERGRADUATES SITES PROGRAM AND THE ESTABLISHED PROGRAM TO STIMULATE COMPETITIVE RESEARCH (EPSCOR). THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

COLLABORATIVE RESEARCH: REVEALING ESSENTIAL REGULATORY PROTEINS IN TARDIGRADE CRYPTOBIOSIS -TARDIGRADES (WATER BEARS) ARE EIGHT-LEGGED, MICROSCOPIC INVERTEBRATES RENOWNED FOR THEIR ABILITY TO SURVIVE EXTREME STRESS. THE HALLMARK OF THIS SURVIVAL IS THEIR UNIQUE ABILITY TO FORM A ?TUN,? A SURVIVAL STATE ACHIEVED THROUGH WITHDRAWING OF LIMBS, EXPELLING INTERNAL WATER STORES, AND SIGNIFICANTLY DECREASING METABOLISM. TARDIGRADES CAN REMAIN IN THIS STATE FOR YEARS WHILE REMAINING RELATIVELY UNDAMAGED, EMERGING ONLY WHEN THE EXTERNAL THREAT HAS BEEN REMOVED. HOWEVER, HOW THIS SURVIVAL IS REGULATED IS LARGELY UNKNOWN. THE INVESTIGATORS' WORK HAS REVEALED A DEPENDENCE OF TARDIGRADE SURVIVAL ON THE PRESENCE OF HIGHLY REACTIVE OXYGEN-CONTAINING CHEMICALS, SMALL CELLULAR MESSENGERS PRESENT IN ALL LIVING SYSTEMS. THESE CHEMICALS ARE ESSENTIAL SIGNALING MOLECULES THAT ALTER METABOLIC ACTIVITY THROUGH THE MODIFICATION OF PROTEINS WITHIN THE CELL. THE MULTIDISCIPLINARY TEAM OF SCIENTISTS FROM THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL AND MARSHALL UNIVERSITY CAN TRACK THESE SIGNALS AND AFFECTED BIOLOGICAL COMPOUNDS WITHIN TARDIGRADES THROUGH POWERFUL ANALYTICAL AND BIOCHEMICAL METHODS. THE INVESTIGATOR TEAM WILL COMBINE THESE APPROACHES TO COMPREHENSIVELY MAP THE ENTRANCE AND EMERGENCE OF TARDIGRADE INTO AND FROM TUN ACROSS UNIQUE STRESSES ALLOWING THEM TO DETERMINE THE PRECISE ADAPTATIONS THAT ENABLE EXTREME STRESS TOLERANCE. THIS WORK IS INTEGRAL TO UNDERSTANDING MOLECULAR STRATEGIES FOR EXTREME STRESS TOLERANCE WITHIN CELLS THAT CAN BE APPLIED TO UNDERSTAND STRESS ACROSS LIFE ON EARTH. THE COLLABORATIVE TEAMS WILL CREATE SISTER COURSES ON THEIR CAMPUS, WORKING ACROSS INSTITUTIONS TO CHARACTERIZE DIFFERENT TARDIGRADE PROTEINS. IN ADDITION, STUDENTS WILL BE ENGAGED IN UNDERGRADUATE RESEARCH AND GAIN EXPERIENCE IN PROTEIN CHEMISTRY, COMPUTATIONAL MODELING, AND SCIENTIFIC LITERACY. TARDIGRADES (WATER BEARS) ARE COSMOPOLITAN MICROSCOPIC INVERTEBRATES THAT RESPOND QUICKLY TO ENVIRONMENTAL STRESSORS USING INGENIOUS MODES OF EXTREMOTOLERANCE COLLECTIVELY KNOWN AS CRYPTOBIOSIS. UNDERSTANDING THE REGULATORY PROCESSES GOVERNING TARDIGRADE CRYPTOBIOSIS IS ESSENTIAL TO REVEALING THE MOLECULAR STRATEGIES THAT PRESERVE BIOCHEMICAL PATHWAYS WHEN EXPOSED TO EXTREME STRESS. WHILE CRYPTOBIOSIS IS PREVALENT ACROSS TAXA, THERE EXISTS ONLY A NASCENT UNDERSTANDING OF THE MOLECULAR MECHANISMS AND TO WHAT EXTENT DIFFERENT TYPES ARE INTERCONNECTED. WE ARE FAR FROM A COMPREHENSIVE UNDERSTANDING OF THE BIOCHEMICAL PARTICIPANTS, THE COORDINATION AMONG DIVERSE NETWORKS, OR OF THE INTERPLAY BETWEEN STRESS AND SURVIVAL. A MULTI-DISCIPLINARY TEAM WILL COMBINE THEIR EXPERTISE IN PROTEOMICS AND REACTIVE OXYGEN SPECIES MONITORING WITH THE AIM OF ELUCIDATING THE REDOX-DEPENDENCE OF TARDIGRADE EXTREMOTOLERANCE. THEY WILL CHARACTERIZE TARDIGRADE SURVIVAL ON BOTH A PHYSIOLOGICAL AND PROTEOMIC LEVEL, ENABLING ENHANCED UNDERSTANDING OF THE MOLECULAR MECHANISMS THROUGH WHICH TARDIGRADES SURVIVE VARIOUS HOSTILE ENVIRONMENTS. PROJECT OUTCOMES INCLUDE: A) THE IDENTIFICATION AND CHARACTERIZATION OF ESSENTIAL REDOX-MODIFIED PROTEINS REQUIRED FOR CRYPTOBIOSIS INDUCTION; B) THE MAPPING OF REDOX SIGNALING ACROSS DISTINCT CRYPTOBIOSES; AND C) THE IDENTIFICATION OF KEY REGULATORY POINTS IN THE TARDIGRADE ?CRYPTOBIOME?. THIS WORK WILL GENERATE THE MOST COMPREHENSIVE BIOMOLECULAR FRAMEWORK FOR CRYPTOBIOSIS, TO DATE. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

WV WATER QUALITY: BACTERIAL SOURCE TRACING AND PATHOGEN PROFILING

BROADENING OUR REACH: A COMMUNITY E-LEARNING INITIATIVE AT MECA&D

BEHAVIORAL HEALTH WORKFORCE EDUCATION AND TRAINING (BHWET) PROGRAM

STUDENT SUPPORT SERVICES TRIO PROGRAM

REU SITE: SAFETY ANALYSIS AND DESIGN NEXUS: BRIDGING THEORY AND PRACTICE -THE THREE-YEAR NSF RESEARCH EXPERIENCES FOR UNDERGRADUATES (REU) SITE: SAFETY ANALYSIS AND DESIGN NEXUS: BRIDGING THEORY AND PRACTICE IS HOSTED BY MARSHALL UNIVERSITY. THIS PROJECT ENGAGES STUDENTS IN ENGINEERING RESEARCH IN THE FIELDS OF SAFETY ANALYSIS AND DESIGN ACROSS DIVERSE INDUSTRIES. PARTICIPANTS, PARTICULARLY THOSE ATTENDING TWO-YEAR AND COMMUNITY COLLEGES WITHIN THE APPALACHIAN REGION, AND THOSE OUTSIDE OF STEM DISCIPLINES WILL BE RECRUITED FOR THIS PROJECT. STATE-OF-THE-ART EQUIPMENT, LABORATORIES, AND COMPUTATIONAL RESOURCES, SUCH AS THE INDUSTRIAL ERGONOMICS LAB AND THE EXTENDED REALITY AND INFRASTRUCTURE SYSTEMS LAB ALONGSIDE FACULTY MENTORS, WILL IMMERSE STUDENTS IN A DYNAMIC AND SUPPORTIVE ATMOSPHERE. PARTICIPANTS WILL ENGAGE IN RESEARCH GUIDED BY DISTINGUISHED EXPERTS IN MECHANICAL ENGINEERING, INDUSTRIAL ENGINEERING, BIOMEDICAL ENGINEERING, CIVIL ENGINEERING, AND COMPUTER SCIENCE, THROUGH THESE KINDS OF IMMERSIVE RESEARCH EXPERIENCES, THE PROGRAM AIMS TO CONNECT NON-STEM AND STEM DOMAINS, DIVERSIFY THE TALENT POOL, AND EMPOWER NON-STEM STUDENTS WITH ESSENTIAL SKILLS. ULTIMATELY, THIS REU SITE ESTABLISHES A PATHWAY FOR INDIVIDUALS FROM NON-STEM BACKGROUNDS TO PURSUE CAREERS IN SAFETY-FOCUSED STEM FIELDS. THE THREE-YEAR NSF RESEARCH EXPERIENCES FOR UNDERGRADUATES (REU) SITE: SAFETY ANALYSIS AND DESIGN NEXUS: BRIDGING THEORY AND PRACTICE IS HOSTED BY MARSHALL UNIVERSITY. OVER A 10-WEEK PROGRAM, STUDENTS WILL ACTIVELY PARTICIPATE IN HANDS-ON RESEARCH, COLLABORATING CLOSELY WITH MENTORS TO ACQUIRE INVALUABLE SKILLS AND EXPERTISE IN SAFETY ANALYSIS AND DESIGN. MARSHALL UNIVERSITY WILL CAPITALIZE ON ITS NATIONALLY ACCLAIMED OCCUPATIONAL SAFETY AND HEALTH PROGRAM. THE UNIVERSITY WILL PROVIDE STATE-OF-THE-ART EQUIPMENT, LABORATORIES, AND COMPUTATIONAL RESOURCES, SUCH AS THE INDUSTRIAL ERGONOMICS LAB AND THE EXTENDED REALITY (XR) AND INFRASTRUCTURE SYSTEMS (ERIS) LAB. ALONGSIDE FACULTY MENTORS, STUDENTS WILL EXPERIENCE A DYNAMIC AND SUPPORTIVE ATMOSPHERE, AND BE GUIDED BY DISTINGUISHED EXPERTS IN MECHANICAL ENGINEERING, INDUSTRIAL ENGINEERING, BIOMEDICAL ENGINEERING, CIVIL ENGINEERING, AND COMPUTER SCIENCE. ADDITIONALLY, STUDENTS WILL ENGAGE IN THEMED SEMINARS, PROFESSIONAL DEVELOPMENT SESSIONS, TECHNICAL AND CAREER WORKSHOPS, AS WELL AS LABORATORY AND INDUSTRY VISITS. THIS EXPERIENTIAL LEARNING FRAMEWORK WILL IMMERSE STUDENTS IN AUTHENTIC REAL-WORLD SCENARIOS, PROVIDING THEM WITH HANDS-ON EXPERIENCE ESSENTIAL FOR ACQUIRING THE SKILLS AND COMPETENCIES SOUGHT AFTER BY EMPLOYERS IN SAFETY-RELATED INDUSTRIES. THIS PROJECT IS JOINTLY FUNDED BY THE EEC REU AND THE ESTABLISHED PROGRAM TO STIMULATE COMPETITIVE RESEARCH (EPSCOR). THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

ADAR2 AND ADIPOSE DYSFUNCTION IN AGING

RUI: BIOLOGICAL ENGINEERING OF NEURAL MIGRATORY STREAMS

WORKFORCE TRAINING

MRI: ACQUISITION OF AN EPR SPECTROMETER FOR STUDIES IN BIOCHEMISTRY, CHEMISTRY, AND PHYSICS

ULTRASOUND GUIDED SITE-SPECIFIC GENE DELIVERY IN PROSTATE CANCER

MRI: TRACK 1 ACQUISITION OF SMARTLAB SE X-RAY DIFFRACTOMETER FOR MULTIDISCIPLINARY RESEARCH ENHANCEMENT AT MARSHALL UNIVERSITY -THE PROJECT ENABLES THE ACQUISITION OF A STATE-OF-THE-ART RIGAKU SMARTLAB SE X-RAY DIFFRACTION SYSTEM (XRD) TO BE HOUSED IN THE COLLEGE OF SCIENCE AT MARSHALL UNIVERSITY. THE INSTRUMENT WILL EXPAND RESEARCH CAPABILITIES AND RELATED EDUCATIONAL INITIATIVES ACROSS A MULTITUDE OF DISCIPLINES INCLUDING MATERIALS SCIENCE, CHEMISTRY, PHYSICS, ENGINEERING, GEOLOGY, FORENSICS, AND PHARMACEUTICS. RESEARCH AND DESIGN OF NOVEL MATERIALS HAVE EXPANDED DRAMATICALLY IN RECENT YEARS, AND THE STRUCTURAL CHARACTERIZATION DATA GENERATED BY ADVANCED DIFFRACTOMETER SYSTEMS LIE AT THE CORE OF EMERGING MATERIALS TECHNOLOGIES. REFLECTING THAT TREND, THE NEW XRD SYSTEM WILL PROVIDE EDUCATIONAL OPPORTUNITIES AND HANDS-ON TRAINING TO OVER 63 GRADUATE STUDENTS, AND 425 UNDERGRADUATES. THE NEW SYSTEM WILL REPLACE AN OBSOLETE GE XRD-6D/VS4 DIFFRACTOMETER INSTALLED IN THE 1970S. THE SMARTLAB SE SYSTEM IS IDEAL FOR BRIDGING THE DUAL RESEARCH AND EDUCATIONAL NEEDS OF THE MARSHALL UNIVERSITY COMMUNITY, AS IT IS HIGHLY AUTOMATED, MODULAR, AND MULTIPURPOSE. THE INSTRUMENT IS SUITABLE FOR A RANGE OF MATERIALS AND SAMPLE TYPES AND HAS THE FLEXIBILITY TO BE USED FOR BOTH RESEARCH AND EDUCATION, GIVEN ITS EASE OF OPERATION AND ACCESSIBILITY TO BOTH NOVICE AND EXPERIENCED USERS. THE SMARTLAB SE XRD INSTRUMENT REPRESENTS A QUANTUM LEAP IN STRUCTURAL ANALYSIS CAPABILITIES AT MARSHALL UNIVERSITY. THE SYSTEM WILL SIGNIFICANTLY ENHANCE THE UNIVERSITY?S RESEARCH PROFILE, LEADING TO NEW INSIGHTS IN MULTIPLE SCIENTIFIC FIELDS. EXAMPLES SPECIFIC TO THIS PROJECT INCLUDE ADVANCED RESEARCH INTO THE DEVELOPMENT OF NEW MATERIALS FOR ION BATTERIES, THE STUDY OF POLYMORPHISMS IN CANCER DRUGS, IDENTIFICATION OF CLAY MINERALS IN UNITS OF SHALE, FIRECLAY, AND TONSTIEN WITH SIGNIFICANT AMOUNTS OF RARE EARTH MINERALS, AND THE CHARACTERIZATION OF BIOMATERIALS FOR TISSUE ENGINEERING, AMONG OTHER THRUSTS. THE INSTRUMENT?S ADVANCED FEATURES WILL ALLOW FOR MORE PRECISE AND ACCURATE EXPERIMENTATION, OPENING DOORS TO INNOVATIVE RESEARCH THAT WAS PREVIOUSLY NOT FEASIBLE UTILIZING THE PRIOR X-RAY DIFFRACTOMETER. FROM THE SOCIETAL PERSPECTIVE, THE INSTRUMENT WILL 1) ENHANCE EDUCATIONAL OBJECTIVES THROUGH THE INCORPORATION OF XRD INTO THE CURRICULUM, 2) PROMOTE A CULTURE OF SHARED RESOURCES BY FOSTERING COLLABORATION WITH OTHER INSTITUTIONS AND STATE AGENCIES, 3) ADVANCE STEM OUTREACH TO UNDERREPRESENTED GROUPS, RECOGNIZING THAT WEST VIRGINIA RANKS 49TH IN MEDIAN HOUSEHOLD INCOME IN THE COUNTRY AND MARSHALL?S UNDERGRADUATE POPULATION INCLUDES 48% FIRST-GENERATION COLLEGE STUDENTS, AND 4) EXTEND THE PROJECT?S IMPACTS BEYOND ACADEMIA, BENEFITING LOCAL COMMUNITIES, AND INDUSTRIES. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

ALCOHOL AND IRON DERIVED OXIDANT STRESS IMPACT EPIGENETIC REGULATION

REU SITE: COMPUTATIONAL SCIENCE TRAINING AT MARSHALL UNIVERSITY FOR UNDERGRADUATES IN THE MATHEMATICAL AND PHYSICAL SCIENCES

HEALTH PROMOTION/DISEASE PREVENTION

REU SITE: INVESTIGATION OF SUBTERRANEAN FEATURES IN THE APPALACHIAN REGION -THIS THREE-YEAR REU SITE AT MARSHALL UNIVERSITY (MU) WILL RECRUIT STUDENTS ENROLLED IN NON-STEM MAJORS AT COMMUNITY COLLEGES LOCATED IN THE SOUTHERN APPALACHIAN REGION TO PARTICIPATE IN ENGINEERING RESEARCH RELATED TO SUBTERRANEAN FEATURES. THE 70-ACRE MU SUBTERRANEAN CAVITY RESEARCH AND TRAINING (MUSCRAT) PARK INCLUDES MINED SHAFTS, CULVERTS, AND TEST PITS THAT WILL BE UTILIZED FOR THE REU PROJECT DATA COLLECTION. RESEARCH ACTIVITIES ARE DESIGNED TO PROMOTE THE PROGRESS OF SCIENCE THROUGH SUBTERRANEAN HAZARD INVESTIGATION AND SUSTAINABLE USES OF ABANDONED COAL MINES. THIS REU SITE AIMS PROVIDE EDUCATIONAL OPPORTUNITIES FOR STUDENTS IN THE ECONOMICALLY DEPRESSED SOUTHERN APPALACHIAN REGION FROM COMMUNITY COLLEGES, PARTICULARLY THOSE FROM NON-STEM MAJORS. THIS THREE-YEAR REU SITE AT MARSHALL UNIVERSITY INVOLVES FACULTY AND GRADUATE STUDENT MENTORS FROM THE DEPARTMENTS OF CIVIL ENGINEERING AND MECHANICAL ENGINEERING. LOCATED IN THE 70-ACRE MU SUBTERRANEAN CAVITY RESEARCH AND TRAINING (MUSCRAT) PARK, THE PROJECT OBJECTIVES ARE TO: (1) PROVIDE COMMUNITY COLLEGE STUDENTS, PARTICULARLY THOSE FROM NON-STEM MAJORS, WITH AN ENGINEERING RESEARCH EXPERIENCE; (2) IMPROVE PARTICIPANTS? RESEARCH AND CREATIVE ABILITIES; (3) IMPROVE PARTICIPANTS? COMMUNICATION SKILLS; AND (4) INCREASE THE NUMBER OF WOMEN, UNDERREPRESENTED MINORITIES, VETERANS, AND FIRST-GENERATION COLLEGE STUDENTS CHOOSING TO PURSUE DEGREES (BOTH UNDERGRADUATE AND GRADUATE) OR CAREERS IN ENGINEERING AND OTHER STEM FIELDS. EXAMPLES OF THE PLANNED RESEARCH TOPICS INCLUDE NON-DESTRUCTIVE DETECTION OF VOIDS AND POTENTIAL SINKHOLES (E.G., KARST), TECHNOLOGIES TO EXPLORE AND MAP ABANDONED COAL MINES, USE OF MINE POOLS FOR GEOTHERMAL HEATING AND COOLING, AND ACID MINE DRAINAGE MITIGATION. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

MATERNAL CONSUMPTION OF OMEGA 3 FATTY ACIDS TO REDUCE BREAST CANCER RISK IN OFFSPRING

SILVER NANOPARTICLE-MEDIATED DISRUPTION OF MICROTUBULE STABILIZATION AND CELLULAR MORPHOLOGICAL DEVELOPMENT IN THE NERVOUS SYSTEM. -MANY CONSUMER AND MEDICAL PRODUCTS (E.G. ATHLETIC WEAR, PLASTICS, COSMETICS, AND WOUND DRESSINGS) CONTAIN ENGINEERED SILVER NANOPARTICLES TO PREVENT BACTERIAL GROWTH. THIS CAN RESULT IN THE CONTAMINATION OF SURFACE WATERS, WASTEWATERS, AND AGRICULTURAL LANDS AND TO CHRONIC LOW-LEVEL EXPOSURE OF ANIMALS FROM MANUFACTURING AND DISPOSAL. IN ADDITION, NANOPARTICLES CAN MOVE UP THE FOOD CHAIN IN ENVIRONMENTAL SYSTEMS. SILVER NANOPARTICLES EASILY BYPASS THE LININGS OF THE GUT AND LUNGS AND MOVE INTO ORGANS, INCLUDING THE BRAIN WHERE THEY STAY FOR MANY MONTHS OR MORE. THIS MEANS THAT FREQUENT EXPOSURE MAY LEAD TO ACCUMULATION OF LOW LEVELS OF NANOSILVER IN THE BRAIN. THEREFORE, IT IS IMPORTANT TO UNDERSTAND HOW BRAIN FUNCTION IS ALTERED BY RESIDENT SILVER NANOPARTICLES AT LEVELS LOWER THAN THOSE THAT KILL CELLS. THIS PROJECT WILL PROVIDE INSIGHT INTO HOW SILVER NANOPARTICLES INTERACT WITH THE COMPLEX BIOLOGICAL MECHANISMS INVOLVED IN BRAIN CELL DEVELOPMENT AND FUNCTION. USING CELLS IN CULTURE AND A SIMPLE ANIMAL MODEL, THE RESEARCH TEAM WILL INVESTIGATE NANOSILVER INTERACTIONS WITH SPECIFIC PROTEINS TO PROVIDE A DEEPER PERSPECTIVE ON THE CONSEQUENCES THAT RESIDENT SILVER NANOPARTICLES HAVE ON BRAIN CELL FUNCTION. THIS WORK WILL HELP DETERMINE THE IMPACTS THAT CHRONIC NANOSILVER EXPOSURES MIGHT HAVE ON MECHANISMS SUCH AS LEARNING AND NEURODEGENERATION. THE ACTIVITIES WILL BE CARRIED OUT BY AN UNDERGRADUATE WORKFORCE AT A PRIMARILY UNDERGRADUATE INSTITUTION IN APPALACHIA THAT HAS A HIGH PROPORTION OF FIRST-GENERATION STUDENTS. THIS PROJECT WILL PROVIDE STUDENTS WITH EXPERIENCE AND TRAINING FOR SUCCESS IN POSTGRADUATE PROGRAMS AND SCIENCE CAREERS. IN CONTRAST TO TISSUES LIKE LIVER, EVERY PART OF THE BRAIN HAS UNIQUE FUNCTION, AND MAY NOT BE ABLE TO COMPENSATE FOR LOCAL DAMAGE RESULTING FROM BIOACCUMULATED SILVER NANOPARTICLES. NANOSILVER EXPOSURE DISRUPTS CYTOSKELETAL ORGANIZATION, INHIBITS NEURITE DYNAMICS, AND ALTERS INTRACELLULAR SIGNALING PATHWAYS IN CULTURED NEURAL CELLS. MOREOVER, RATS EXPOSED TO ORAL SILVER NANOPARTICLES EXHIBITED DYSREGULATION OF NEUROGENESIS AND ACCUMULATION OF PTAU, A HALLMARK OF NEURODEGENERATION. HOWEVER, THE CELLULAR MECHANISMS TARGETED BY SILVER NANOPARTICLES TO INDUCE THESE EFFECTS ARE UNKNOWN. THE OVERARCHING OBJECTIVE OF THIS RESEARCH IS TO UNDERSTAND THE MOLECULAR BASIS OF THE INTERACTION OF SILVER NANOPARTICLES WITH CYTOSKELETAL CONTROL MECHANISMS TO INDUCE MORPHOLOGICAL AND FUNCTIONAL DEFICITS IN NEURAL CELLS. SEVERAL LINES OF EVIDENCE IDENTIFIED COLLAPSIN RESPONSE MEDIATOR PROTEIN-2 (CRMP-2) AND ITS CONTROLLER GLYCOGEN SYNTHASE KINASE 3? (GSK3?) AS CANDIDATE TARGETS. FIRST, THIS PROJECT WILL DETERMINE IF NANOSILVER EXPOSURE LEADS TO DISRUPTION OF LOCALIZATION OR ACTIVATION OF THESE KEY CYTOSKELETAL REGULATORS IN CULTURED NEURAL CELLS. THEN, STRAINS OF THE NEMATODE WORM CAENORHABDITIS ELEGANS WILL BE USED TO MEASURE HOW EXPOSURE TO NANOSILVER DURING DEVELOPMENT ALTERS MORPHOLOGICAL DEVELOPMENT. STRAINS EXPRESSING FLUORESCENT FUSION PROTEINS WILL BE USED TO ASSESS THE FUNCTION OF THE HIGHLY CONSERVED WORM HOMOLOGUE OF CRMP-2 (UNC-33) AND PRE-AND POST-SYNAPTIC STRUCTURAL CHANGES IN NEURONS OF WORMS EXPOSED TO NANOSILVER DURING DEVELOPMENT. THIS IS IMPORTANT BECAUSE CYTOSKELETAL CONTROL OF MORPHOLOGICAL DEVELOPMENT IS KEY TO SYNAPTIC FUNCTION. BEHAVIORAL ASSAYS AND OPTOGENETICS WILL QUANTIFY NEURAL FUNCTION OF WHOLE WORMS AND INDIVIDUAL NEURONS AFTER DEVELOPMENT UPON EXPOSURE TO SILVER NANOPARTICLES. FINALLY, THE WORM MODEL SYSTEM WILL BE USED TO FURTHER EXAMINE THE FORMATION OF PTAU AGGREGATES IN RESPONSE TO SILVER NANOPARTICLE EXPOSURE. THIS WORK WILL OFFER MECHANISTIC SUBSTRATES FOR UNDERSTANDING NANOSILVER-INDUCED ALTERATIONS IN NEURAL PLASTICITY AND DEVELOPMENT. THE PROJECT DESIGN IS OPTIMIZED FOR UNDERGRADUATE RESEARCHERS WITH MODULAR AND COMPLEMENTARY EXPERIMENTS THAT ALLOW EACH STUDENT TO PURSUE THEIR OWN PROJECT WHILE CONTRIBUTING TO THE OVERALL GOALS OF THE TEAM. THE PI WILL ALSO DEVELOP A NEW BIOLOGY CAPSTONE COURSE THAT WILL HELP STUDENTS DEVELOP SKILLS IN INTERPRETING SCIENTIFIC DATA AND FOSTER CRITICAL ASSESSMENT OF PRIMARY SCIENCE AND ITS COVERAGE IN THE MAINSTREAM MEDIA. HIGH SCHOOL STUDENTS WILL PARTICIPATE IN THESE CLASS MEETINGS TO PROMOTE SCIENTIFIC RESEARCH AS A CAREER PATH AND TO RECRUIT STUDENTS TO UNDERGRADUATE SCIENCE PROGRAMS. THIS PROJECT IS JOINTLY FUNDED BY THE NANOSCALE INTERACTIONS PROGRAM (NI) AND THE ESTABLISHED PROGRAM TO STIMULATE COMPETITIVE RESEARCH (EPSCOR). THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

MEDICATION ASSISTED TREATMENT EDUCATION DISSEMINATION IN WEST VIRGINIA (MAT ED) - TITLE: MEDICATION ASSISTED TREATMENT EDUCATION DISSEMINATION IN WV (MAT ED) THIS COLLABORATIVE PROJECT BETWEEN ALL THREE MEDICAL SCHOOLS IN WEST VIRGINIA, THE JOAN C. EDWARDS SCHOOL OF MEDICINE, WEST VIRGINIA UNIVERSITY SCHOOL OF MEDICINE (WVU), AND THE WEST VIRGINIA SCHOOL OF OSTEOPATHIC MEDICINE (WVSOM), WITH SUPPORT FROM THE WEST VIRGINIA HIGHER EDUCATION POLICY COMMISSION WILL DRAMATICALLY INCREASE THE NUMBER OF EDUCATED PROVIDERS WHO CAN PROVIDE MEDICATION ASSISTED TREATMENT (MAT) BY IMBEDDING MAT TRAINING INTO THE STANDARD OR ELECTIVE MEDICAL SCHOOL CURRICULUM. THE NEED TO TRAIN MEDICAL PROFESSIONALS ON ADDICTION TREATMENT IN WEST VIRGINIA HAS NEVER BEEN MORE IMPORTANT. WEST VIRGINIA HAS BEEN RAVAGED BY THE IMPACTS OF OPIOID ADDICTION EPIDEMIC. FOR THE PAST DECADE, WEST VIRGINIA HAS HAD THE HIGHEST PER CAPITAL DEATH RATE FROM OPIOID USE AND HAS SHOWN THE LARGEST INCREASE IN NEONATAL ABSTINENCE SYNDROME (NAS) CASES IN THE NATION. CURRENTLY, THE NUMBER OF MAT PROVIDERS IN WV FALLS FAR SHORT OF THE NEED FOR SERVICES. BY IMPROVING EDUCATION AROUND ADDICTION TREATMENT, INCLUDING AWARENESS, RECOGNITION, AND STIGMA, THIS PROJECT WILL ALSO HELP DEVELOP A MORE COMPASSIONATE AND EQUIPPED GENERATION OF HEALTH CARE PROVIDERS. ADDITIONALLY, THIS PROJECT WILL SEEK TO EXPAND MAT TRAINING INTO OTHER PRESCRIBER DISCIPLINES INCLUDING NURSE PRACTITIONERS AND PHYSICIAN ASSISTANTS. DUE TO THE CURRENT OBLIGATIONS PLACED ON MEDICAL FACULTY, IT IS NECESSARY TO ESTABLISH A SINGLE COORDINATOR FOR THE STATE WHO IS ABLE TO ASSIST IN CURRICULUM DEVELOPMENT AND HELP PROGRAMS AND STUDENTS OVERCOME THE BARRIERS TO MAT TRAINING AND ESTABLISHING THEIR MAT WAIVER. THE PROJECT WILL ALSO PROMOTE FACULTY CHAMPIONS AT THE MEDICAL SCHOOLS WHO KNOW THE INNER WORKINGS OF THEIR PROGRAMS AND ARE COMMITTED TO IMPLEMENTATION SUCCESS. THIS COLLABORATIVE PROJECT IS UNIQUELY POSITIONED TO IMPROVE THE PROVIDER PIPELINE IN A HIGH NEED REGION THROUGH A SUSTAINABLE MODEL FOR CURRICULUM INTEGRATION.

BASE DE-EE0009544 CLEAN CITIES COALITION NETWORK OUTREACH, EDUCATION AND PERFORMANCE TRACKING PROGRAM

ESTABLISHMENT OF A HUMAN ENTEROID MODEL OF CRYPTOSPORIDIOSIS

MU SPEAC - MARSHALL UNIVERSITY SEEKS TO CREATE AN EXPANDED SUICIDE PREVENTION PROGRAM THAT WILL SYSTEMATICALLY CREATE A CAMPUS ENVIRONMENT THAT IS STRONGER AND SAFER FOR ALL STUDENTS, STAFF, AND FACULTY. MULTIPLE ACADEMIC AND CAMPUS DEPARTMENTS ARE INVOLVED, INCLUDING; SOCIAL WORK, PSYCHOLOGY, COUNSELING, PUBLIC HEALTH, NURSING, THE STUDENT COUNSELING CENTER, COLLEGE OF HEALTH PROFESSIONS BEHAVIORAL HEALTH CENTER, THE LGBTQ OFFICE, AND THE ATHLETIC DEPARTMENT. ADDITIONALLY, VARIOUS DEPARTMENTS AT OTHER HIGHER LEARNING INSTITUTIONS IN WEST VIRGINIA WILL BECOME PARTNERS IN THIS EFFORT. THE INTER-COLLEGIATE PARTNERSHIP WILL TAKE PLACE WITH MARSHALL UNIVERSITY-SPEAC AND SMALLER SCHOOLS THAT CANNOT MEET THE MATCH STANDARD OF THE GLS: WHEELING UNIVERSITY, WEST LIBERTY UNIVERSITY, DAVIS & ELKINS COLLEGE, MOUNT WEST COMMUNITY AND TECHNICAL COLLEGE, BRIDGE VALLEY COMMUNITY AND TECHNICAL COLLEGE, GLENVILLE STATE UNIVERSITY, AND A STATEWIDE ORGANIZATION COLLEGIATE RECOVERY PROGRAM. TRAININGS WILL BE OFFERED TO INCREASE KNOWLEDGE ON HOW TO MAKE A SAFER CAMPUS AND HOW TO PROVIDE SERVICES TO STUDENTS EXPERIENCING MENTAL HEALTH ISSUES AND POSSIBLE CRISIS. QPR TRAINING WILL BE PROVIDED TO INCREASE AWARENESS OF THE ISSUES AND TO HELP PARTICIPANTS RECOGNIZE BEHAVIORS THAT ARE INDICATIVE OF SUICIDAL IDEATION. QPR WILL ALSO PROVIDE PARTICIPANTS WITH INFORMATION ABOUT HOW TO RESPOND TO STUDENTS AT RISK FOR SUICIDE. SUICIDE IS CURRENTLY THE SECOND LEADING CAUSE OF DEATH AMONG COLLEGE AGE STUDENTS IN THE U.S. THE GOALS AND OBJECTIVES FOR THE MU-SPEAC ARE AS FOLLOWS: TO DEVELOP KNOWLEDGE AND EDUCATION AMONG CAMPUS ADMINISTRATORS AND LEADERSHIP THROUGH PRESENTATIONS AND TRAININGS ON THE IMPORTANCE OF SUICIDE PREVENTION; TO EDUCATE THE COMMUNITY OF STUDENTS ON THE MARSHALL UNIVERSITY CAMPUS AND ON OUR PARTNER CAMPUSES AS WELL. GATEKEEPER TRAINING WITH TARGETED GROUPS OF STUDENTS, STAFF, FACULTY, AND COMMUNITY STAKEHOLDERS, AS WELL AS OFFERED TO PARENTS OF MARSHALL UNIVERSITY STUDENTS DURING ORIENTATION. OTHER ELEMENTS OF THE GATEKEEPER TRAINING INCLUDE HELPING PARTICIPANTS TO IDENTIFY DEPRESSION AND OTHER MENTAL HEALTH ISSUES; TO EDUCATE PARTICIPANTS ABOUT THE WARNING SIGNS OF SUICIDE AND THE INTERVENTION PROCESS USING MENTAL HEALTH FIRST AID; TO DEVELOP AND TO BUILD A LASTING AND SOLID INFRASTRUCTURE FOR THE MU-SPEAC PREVENTION PLAN. THE MARSHALL UNIVERSITY SPEAC PROGRAM WILL FOLLOW THE MODEL OUTLINED BY THE JED FOUNDATION CAMPUSMHAP, USING EVIDENCED-BASED DATA DRIVEN TRAININGS AND EDUCATION TO DEMONSTRATE THE USE OF BEST PRACTICE METHODS. OPTIONS FOR VIRTUAL OR FACE-TO-FACE TRAININGS WILL BE OFFERED FOR A VARIETY OF TRAININGS TO INCLUDE: MENTAL HEALTH FIRST AID, QPR, SAFETALK, START, TEACHABLE MOMENTS BRIEF INTERVENTION, CAMS, TF-CBT, AND A JOINT CONFERENCE (HESPC) WHICH WILL BE A FIRST FOR WEST VIRGINIA HIGHER EDUCATION SCHOOLS.

EDA UNIVERSITY CENTER CARES ACT SUPPLEMENTAL FUNDING

EARMARKS

RII TRACK-4:@NASA: INVESTIGATION OF TWO-PHASE AEROSOL FORMATION, TRANSPORT, AND DEPOSITION IN AEROSOL JET PRINTING FOR SUBMICRON MANUFACTURING OF PRINTED ELECTRONIC DEVICES -THIS PROJECT WILL PROVIDE A FELLOWSHIP TO AN ASSISTANT PROFESSOR, AND A GRADUATE STUDENT AT THE MARSHALL UNIVERSITY RESEARCH CORPORATION (MARSHALL) TO CONDUCT RESEARCH IN COLLABORATION WITH RESEARCHERS AT THE NASA MARSHALL SPACE FLIGHT CENTER IN ALABAMA. THROUGH THE FELLOWSHIP, THE PI AIMS TO IDENTIFY THE KEY PHENOMENA BEHIND THE AERODYNAMICS OF AEROSOLS JET PRINTING THAT AFFECT MATERIAL DEPOSITION AND THUS THE RESOLUTION OF DEVICE FABRICATION. THE U.S. SEMICONDUCTOR INDUSTRY IS A MAJOR ECONOMIC DRIVER, MAKING UP 10% OF THE NATION?S MANUFACTURING SECTOR AND CONTRIBUTING OVER $250 BILLION A YEAR IN VALUE TO THE U.S. ECONOMY. SEMICONDUCTOR DEVICES SUPPORT A WIDE RANGE OF APPLICATIONS, SUCH AS FIFTH-GENERATION (5G) COMMUNICATIONS, ARTIFICIAL INTELLIGENCE, HIGH-PERFORMANCE COMPUTING, SECURITY, AND LOCAL/REMOTE SENSING. COMMERCIAL MARKETS, SUCH AS THE INTERNET-OF-THINGS, HAVE SIGNIFICANTLY INCREASED THE NEED FOR SEMICONDUCTOR-BASED PRODUCTS. ALSO, THE RAPID ADOPTION OF NEW, MORE POWERFUL TECHNOLOGIES IS DRIVING DEMAND FOR ADDITIONAL SEMICONDUCTOR PRODUCTION CAPACITY IN THE U.S. ADDITIONALLY, THERE IS A BURGEONING NEED FOR ?HIGH-RESOLUTION? DEVICE FABRICATION TO FULFILL TODAY?S PERFORMANCE CHARACTERISTICS, SUCH AS LOW POWER CONSUMPTION, FAST SWITCHING SPEEDS, AND INCREASED COMPUTING POWER. AEROSOL JET PRINTING (AJP) HAS EMERGED AS A HIGH-RESOLUTION, DIRECT-WRITE MANUFACTURING METHOD FOR FABRICATION OF A BROAD SPECTRUM OF ELECTRONICS, SUCH AS SENSORS, OPTOELECTRONIC DEVICES, AND FINE-PITCH ELECTRONICS. HOWEVER, DESPITE RECENT ADVANCES IN THE AJP TECHNOLOGY AND FORMULATION OF NOVEL FUNCTIONAL MATE-RIALS, ?SUBMICRON? FABRICATION OF ELECTRONIC DEVICES HAS ENCOUNTERED SERIOUS CHALLENGES DUE LARGELY TO THE INTRINSIC LIMITATIONS AND COMPLEXITY BEHIND THE UNDERLYING PHYSICS OF AJP PROCESS. THERE IS, THEREFORE, A CRITICAL NEED TO IDENTIFY THE LINK BETWEEN THE GOVERNING PHYSICAL PHENOMENA AND THE RESOLUTION OF AJP TOWARD SUBMICRON DEVICE FABRICATION BEYOND TODAY?S LIMITS. THE LONGTERM GOAL OF THIS PROJECT IS TO CONTRIBUTE TOWARD SUBMICRON DIRECT-WRITE FABRICATION OF PRINTED ELECTRONIC DEVICES. IN PURSUIT OF THIS GOAL, THE OVERALL OBJECTIVE OF THE PROJECT IS TO IDENTIFY THE KEY PHENOMENA BEHIND THE AERODYNAMICS OF AJP THAT AFFECT THE RESOLUTION OF MATERIAL DEPOSITION AND ULTIMATELY DEVICE FABRICATION. THE PROPOSED RESEARCH PLAN IS BASED ON ADVANCED COMPUTATIONAL FLUID DYNAMICS (CFD) MODELS, FOLLOWED BY EXPERIMENTAL CHARACTERIZATION OF THE RESOLUTION OF AEROSOL DEPOSITION CARRIED OUT AT NASA?S MARSHALL SPACE FLIGHT CENTER. THE COMPUTATIONAL MODELS INCLUDE NOT ONLY THE 3D GEOMETRY OF VARIOUS AJP DEPOSITION HEADS WITH DIFFERENT AEROSOL HANDLING MECHANISMS, BUT ALSO THE PROCESSES OF TURBULENT AEROSOL ATOMIZATION, TRANSPORT, AND DEPOSITION. THE CONTRIBUTION OF THIS RESEARCH PROJECT WILL BE SIGNIFICANT BECAUSE IT IS EXPECTED: (I) TO IDENTIFY THE KEY AERODYNAMIC PHENOMENA INFLUENCING FEATURE SIZE AND THEREFORE THE RESOLUTION OF MATERIAL DEPOSITION IN AJP, AND (II) TO PAVE THE WAY FOR SUBMICRON DIRECT-WRITE FABRICATION OF SEMICONDUCTOR ELECTRONIC DEVICES (NOT FEASIBLE TODAY). THIS PROJECT WILL SIGNIFICANTLY ENHANCE THE DEVICE FABRICATION CAPABILITY OF THE U.S., WILL STRENGTHEN THE U.S. SEMICONDUCTOR INDUSTRY, AND CONSEQUENTLY WILL CONTRIBUTE TO THE ENHANCEMENT OF NATIONAL PROSPERITY, SECURITY, AND U.S. LEADERSHIP IN MANUFACTURING. IN ADDITION, NASA WILL BE ABLE TO DESIGN, MANUFACTURE, AND TEST NOVEL AJP DEPOSITION HEADS ON THE BASIS OF THE ESTABLISHED COMPUTATIONAL MODELS AS WELL AS EXPERIMENTAL OBSERVATIONS OF THE AJP AERODYNAMICS. FURTHERMORE, THIS PROJECT WILL REDUCE THE SCIENTIFIC BARRIERS THAT LIMIT DIRECT-WRITE ADDITIVE MANUFACTURING AND WILL CATALYZE NEW MANUFACTURING CAPABILITIES THAT HAVE NOT BEEN MATERIALIZED TODAY. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

TINNITUS: EPPIGENETIC MECHANISM AND THERAPY

HEALTH EDUCATION

MRI: ACQUISITION OF A CYTOVIVA ENHANCED MICROSCOPE WITH HYPERSPECTRAL IMAGING CAPABILITY FOR MULTIDISCIPLINARY RESEARCH AND EDUCATION IN NANOTECHNOLOGY

HEALTH PROMOTION/DISEASE PREVENTION

COMBINATION OF NANOFIBER SCAFFOLDS WITH GRADATIONS IN FIBER ORGANIZATION AND MINE

HEALTH PROMOTION/DISEASE PREVENTION

EARMARKS

FY 2015 COMMERCIAL DRIVER'S LICENSE PROGRAM IMPLEMENTATION GRANT

DENTAL CARE

EARMARKS