University School

STRENGTHENING THE GOVERNMENT OF UGANDA'S CAPACITY FOR REGIONALLY CENTERED AND DISTRICT IMPLEMENTED HIV AND TB PROGRAMMING THROUGH HIS, CBS, M&E AND QI SUPPORT

HEALTH CENTER CLUSTER

HIGHER EDUCATION SOLUTIONS NETWORK COOPERATIVE AGREEMENT

MONITORING AND EVALUATION TECHNICAL SUPPORT (METS) TO STRENGTHEN MONITORING AND EVALUATION, DISEASE SURVEILLANCE AND THE CAPABILITIES OF DISTRICT HEALTH TEAMS IN THE REPUBLIC OF UGANDA UNDER

DEVELOPING NATIONAL CAPACITY FOR THE MANAGEMENT OF HIV/AIDS PROG & SUPPORT FOR TH

STRENGTHENING CIVIL SOCIETY ORGANIZATIONS'CAPACITY AND COORDINATION FOR ACCELERATED HIV EPIDEMIC CONTROL IN UGANDA THROUGH SUPPORTING IMPLEMENTATION OF COMPREHENSIVE HIV/AIDS PREVENTION AND TREATMENT

HEALTH CENTER CLUSTER

MONITORING AND EVALUATION TECHNICAL SUPPORT (METS) TO STRENGTHEN MONITORING AND EVALUATION, DISEASE SURVEILLANCE AND THE CAPABILITIES OF DISTRICT HEA

THE SOMATOTROPIC AXIS AND HEALTH AGING: A SEARCH FOR MECHANISMS

STRENGTHEN CAPACITY OF UGANDA MINISTRY OF HEALTH AND SUB - NATIONAL ENTITIES TO EXECUTE ESSENTIAL PUBLIC HEALTH FUNCTIONS THROUGH SUPPORTING PUBLIC HEALTH WORKFORCE DEVELOPMENT AND INSTITUTIONAL...

STRENGTHEN UGANDA MINISTRY OF HEALTH CAPACITY TO EXECUTE ITS ESSENTIAL PUBLIC HEALTH FUNCTIONS THROUGH PROVISION OF TECHNICAL ASSISTANCE, PUBLIC HEALTH WORKFORCE DEVELOPMENT AND INSTITUTIONAL

AMERICAN RESCUE PLAN ACT FUNDING FOR HEALTH CENTERS

CODING IN AUDITORY NEURONS: EFFECTS OF AMINO ACIDS

CELLULAR SENESCENCE, INFLAMMATION AND NEUROTRANSMISSION IN ALZHEIMER'S DISEASE

INTERACTION OF CALORIC RESTRICTION WITH LONGEVITY GENES

GLUTAMATE NEUROTRANSMISSION IN ALZHEIMER'S DISEASE PROGRESSION

OPTIMIZING D-METHIONINE (D-MET) PRE-LOADING AND RESCUE DOSING THROUGH FUNCTIONAL AND BIOMARKER MEASURES

ENDOGENOUS MODULATION OF COCHLEAR INJURY

RURAL COMMUNITIES OPIOID RESPONSE PROGRAM - MEDICATION ASSISTED TREATMENT ACCESS - PROJECT TITLE: SOUTHERN ILLINOIS UNIVERSITY (SIU) COMMUNITY HEALTH PROGRAM MEDICATION ASSISTED TREATMENT (MAT) EXPANSION PROJECT REQUESTED AWARD AMOUNT: $2,669,913 APPLICANT ORGANIZATION NAME: BOARD OF TRUSTEES OF SOUTHERN ILLINOIS UNIVERSITY FACILITY TYPE: PUBLIC UNIVERSITY AND FEDERALLY QUALIFIED HEALTH CENTER ADDRESS: 520 N 4TH STREET, SPRINGFIELD IL 62702-5238 WEBSITE: HTTPS://WWW.SIUMED.EDU/CENTERS-FAMILY-MEDICINE PROJECT DIRECTOR AND TITLE: CAMILLE DUNKLEY, MD, ASSISTANT PROFESSOR OF FAMILY AND COMMUNITY MEDICINE, DIRECTOR OF MEDICATION ASSISTED RECOVERY PROJECT DIRECTOR CONTACT: PHONE: 217-757-8137 FAX: 217-545-5806 EMAIL: CDUNKLEY46@SIUMED.EDU LEARNED OF FUNDING OPPORTUNITY: HRSA NEWS RELEASE & GRANTS.GOV BRIEF DESCRIPTION OF TARGET SERVICE AREA: TWO HRSA-DESIGNATED RURAL COUNTIES (CHRISTIAN AND MORGAN) IN ILLINOIS. TARGET POPULATION: RESIDENTS OF CHRISTIAN COUNTY: 95% WHITE (NON-HISPANIC), 1.3% AFRICAN AMERICAN (NON-HISPANIC), 1.6% HISPANIC OR LATINO, 0.3% AS AMERICAN INDIAN/ALASKA NATIVE (NON-HISPANIC). RESIDENTS OF MORGAN COUNTY: 88% WHITE (NON-HISPANIC), 6.8% AFRICAN AMERICAN (NON-HISPANIC), 2.5% HISPANIC OR LATINO, 0.2% AS AMERICAN INDIAN/ALASKA NATIVE (NON-HISPANIC). THE PRIMARY AIM OF THIS PROJECT IS TO ESTABLISH TWO OUTPATIENT MEDICATION-ASSISTED TREATMENT (MAT) CLINICS IN TAYLORVILLE AND JACKSONVILLE, IL, WHICH ARE IN CHRISTIAN AND MORGAN COUNTY, RESPECTIVELY. THESE CLINICS WILL BE ESTABLISHED WITHIN THE EXISTING SIU CENTER FOR FAMILY MEDICINE PRIMARY CARE CLINICS. THEY WILL PROVIDE LEVEL 1 TREATMENT SERVICES AS DESIGNATED BY THE ILLINOIS SUBSTANCE USE PREVENTION AND RECOVERY (SUPR) LICENSE. THESE CLINICS WILL SERVE PATIENTS WITH OPIOID USE DISORDER, ALCOHOL USE DISORDER, AND CO-OCCURRING ADDICTION AND MENTAL HEALTH DISORDERS. THE MAT OPTIONS WILL INCLUDE SUBLINGUAL BUPRENORPHINE, BUPRENORPHINE EXTENDED-RELEASE INJECTABLE, AND NALTREXONE-EXTENDED RELEASE INJECTABLE. BEHAVIORAL SERVICES WILL BE INTEGRATED INTO THE C LINIC AND OFFERED ON-SITE. ADDITIONAL ADJUNCTIVE SERVICES WILL INCLUDE PEER SUPPORT, COMMUNITY HEALTH WORKERS, AND CASE MANAGEMENT.

ENHANCING PHYSICAL ACTIVITY AFTER BREAST CANCER DIAGNOSIS: RANDOMIZED TRIAL

ORAL EPIGALLOCATECHIN GALLATE (EGCG) FOR TREATMENT OF CISPLATIN OTOTOXICITY

BEHAVIORAL HEALTH WORKFORCE EDUCATION AND TRAINING PROGRAM

SANGAMON COUNTY ILLINOIS ASSISTED OUTPATIENT TREATMENT

FEATURES OF CHRONIC TINNITUS IN AN ANIMAL MODEL AS INDICATED BY MEMRI AND MRS

BEHAVIORAL HEALTH WORKFORCE EDUCATION AND TRAINING PROGRAM- AMERICAN RESCUE PLAN

MONITORING AND EVALUATION TECHNICAL SUPPORT (METS) TO STRENGTHEN MONITORING AND EVALUATION, DISEASE SURVEILLANCE AND THE CAPABILITIES OF DISTRICT HEA

MONITORING AND EVALUATION TECHNICAL SUPPORT (METS) TO STRENGTHEN MONITORING AND EVALUATION, DISEASE SURVEILLANCE AND THE CAPABILITIES OF DISTRICT HEA

AFFORDABLE CARE ACT: PRIMARY CARE RESIDENCY EXPANSION

CEREBELLAR GRANULE CELL DYSFUNCTION IN SHANK3 MUTANT MICE - PROJECT SUMMARY/ABSTRACT AUTISM SPECTRUM DISORDER (ASD) IS A COMPLEX NEUROLOGICAL DISORDER ASSOCIATED WITH A BROAD COLLECTION OF GENETIC MUTATIONS AND ENVIRONMENTAL FACTORS. WHILE IDENTIFYING THE NEURAL UNDERPINNINGS OF ASD HAS BEEN A MAJOR FOCUS IN THE FIELD OF GENETICS AND NEUROSCIENCE, IT IS NOT CLEAR WHICH BRAIN REGION (S) AND CELL TYPES MAY BE FUNCTIONING ABNORMALLY TO GIVE RISE TO ASD. THE CEREBELLUM, A BRAIN REGION TYPICALLY CONSIDERED TO BE INVOLVED IN MOTOR COORDINATION AND CONTROL, HAS RECEIVED CONSIDERABLE ATTENTION FOR ITS POTENTIAL ROLE IN ASD, WITH A GROWING BODY OF CLINICAL EVIDENCE CORRELATING ASD DIAGNOSES WITH ABNORMALITIES IN CEREBELLAR ANATOMY, FUNCTION, AND MOTOR OR VESTIBULAR BEHAVIORS/FUNCTIONS. IN PARALLEL, CEREBELLAR INVOLVEMENT IN CIRCUITS OUTSIDE OF THE MOTOR SYSTEM PROVIDES A SUBSTRATE FOR THE CEREBELLUM TO INFLUENCE NON-MOTOR BEHAVIORS AND PROCESSES, SETTING THE STAGE FOR THE IMPORTANCE OF APPROPRIATE CEREBELLAR FUNCTION IN A HOST OF NEURAL PROCESSES. WITHIN THE CEREBELLUM, THE INITIAL INTEGRATION OF ALL INCOMING SENSORIMOTOR INFORMATION ENTERING THE CEREBELLAR CORTEX IS CARRIED OUT BY THE MORPHOLOGICALLY SIMPLE AND EXTREMELY DENSE POPULATION OF GRANULE CELLS. THESE GRANULE CELLS ALSO EXPRESS MANY HIGH RISK ASD-LINKED GENES, ESPECIALLY THOSE INVOLVED IN SYNAPTIC TRANSMISSION AND DEVELOPMENT. HOWEVER, LITTLE IS KNOWN ABOUT THE ROLE AND IMPORTANCE OF MANY ASD-LINKED GENES IN THE CEREBELLUM, ESPECIALLY IN GRANULE CELLS. IT IS ALSO NOT CLEAR WHAT ASPECTS OF CEREBELLAR GRANULE CELL FUNCTION AND CONNECTIVITY MAY BE IMPORTANT FOR SHAPING CERTAIN NON-MOTOR (AND MOTOR) BEHAVIORS. TO ADDRESS THIS KNOWLEDGE GAP, IN AIMS 1 AND 2 WE PROPOSE TO IDENTIFY THE DEGREE TO WHICH AN ASD-LINKED GENE DETERMINES PROPERTIES OF CEREBELLAR GRANULE CELL SYNAPTIC INTERACTIONS AND CORTICAL CIRCUITRY DYNAMICS OVER TIME. IN AIM 3, WE WILL IDENTIFY HOW A PARTICULAR ASD-LINKED GENE IN CEREBELLAR GRANULE CELLS INFLUENCE BEHAVIORAL PHENOTYPE ACROSS MOTOR AND NON-MOTOR DOMAINS. RESULTS FROM THE PROPOSED WORK WILL BE KEY IN IDENTIFYING A MECHANISTIC LINK BETWEEN A GENE/PROTEIN LINKED TO ASD AND SPECIFIC SYNAPTIC ABNORMALITIES IN THE CEREBELLUM.

MECHANISMS OF FATIGUE IN A CHRONIC VIRAL DISEASE

DEVELOPING D-METHIONINE AS AN AMINOGLYCOSIDE OTOPROTECTANT

NICOTINIC RECEPTOR PATHOLOGY IN TINNITUS: AUDITORY CORTEX AND SELECTIVE DESENSITIZING NICOTINIC AGENTS

NOVEL ROLE OF MYELOID-DERIVED LYMPHATIC PROGENITORS IN INDUCTION OF BREAST CANCER LYMPHATICS

MECHANISMS THAT REGULATE HAIR CELL SURVIVAL

TRANSPLATIN: A NOVEL AGENT TO MITIGATE CISPLATIN TOXICITY

INVESTIGATION OF NOTCH SIGNALING DURING SPONTANEOUS REGENERATION OF COCHLEAR HAIR CELLS

DEVELOPMENT OF NEW THERAPIES THAT STIMULATE HAIR CELL REGENERATION

NF-KB MEDIATED INDUCTION OF VEGFR-3 AND NEW LYMPHATIC VESSELS IN BREAST CANCER

PRIMARY CARE TRAINING AND ENHANCEMENT

A NOVEL APPROACH FOR CHRONIC PAIN TREATMENT USING RESINIFERATOXIN

CIRCADIAN CLOCK DISRUPTION: A MECHANISM FOR DIOXIN-INDUCED METABOLIC SYNDROME

THE GLYCINE RECEPTOR IN A RAT TINNITUS MODEL: A POSSIBLE THERAPEUTIC TARGET

RESEARCH IN PERVENTION AND TREATMENT OF NOISE-INDUCED HEARING LOSS (NHL)

MONITORING AND EVALUATION TECHNICAL SUPPORT (METS) TO STRENGTHEN MONITORING AND EVALUATION, DISEASE SURVEILLANCE AND THE CAPABILITIES OF DISTRICT HEA

BEHAVIORAL HEALTH WORKFORCE EDUCATION AND TRAINING PROGRAM - TRAUMA-BASED BEHAVIORAL HEALTH FELLOWSHIP: HEALING-CENTERED INTEGRATED AND INTERDISCIPLINARY CARE TRAINING PROJECT AIMS TO EXPAND AND SUSTAIN THE TRAUMA-INFORMED BEHAVIORAL HEALTH WORKFORCE IN SOUTHERN ILLINOIS, A REGION CHARACTERIZED BY RURAL, MEDICALLY UNDERSERVED COMMUNITIES (MUCS), AND DESIGNATED BY HRSA AS A HEALTHCARE WORKFORCE SHORTAGE AREA. THIS COLLABORATIVE INITIATIVE SEEKS TO ADDRESS HEALTH DISPARITIES BY ENHANCING THE PROVISION OF TRAUMA-INFORMED, BILINGUAL MENTAL HEALTH SERVICES TO CHILDREN, ADOLESCENTS, AND TRANSITIONAL-AGED YOUTH IN BEHAVIORAL HEALTH (BH) AND INTEGRATED CARE (IC) SETTINGS. AT THE HEART OF THIS PROJECT IS THE WIDELY RECOGNIZED TRAUMA-BASED BEHAVIORAL HEALTH FELLOWSHIP (TBBHF) AT SOUTHERN ILLINOIS UNIVERSITY (SIU) SCHOOL OF MEDICINE (SOM). AN INTEGRATED/INTERPROFESSIONAL TRAINING PROGRAM THAT EQUIPS GRADUATE STUDENTS FOR CAREERS IN BH. THE PROGRAM FOCUSES ON TRAUMA-INFORMED SYSTEMS OF CARE, INTEGRATED HEALTH SYSTEMS, AND PREPARING STUDENTS TO WORK EFFECTIVELY IN INTERDISCIPLINARY TEAMS WITH VULNERABLE POPULATIONS, PARTICULARLY IN RURAL AND UNDERSERVED COMMUNITIES. THIS PROJECT IS FOCUSED ON CHILDREN, ADOLESCENTS AND YOUNG ADULTS. BUILDING ON THE PROGRAM'S 11 YEARS OF SUCCESS, THE CONTINUED FUNDING WILL STRENGTHEN THE HYBRID, INTERDISCIPLINARY DIDACTIC TRAINING CURRICULUM WITH A FOCUS ON HEALING-CENTERED INTEGRATED TRAUMA-INFORMED CARE, EVIDENCE-BASED TRAUMA INTERVENTIONS, TELEHEALTH, AND ENHANCED CLINICAL OFFERINGS FOR STUDENTS, FACULTY, AND FIELD SITE SUPERVISORS. KEY COMPONENTS OF THE CONTINUATION PROJECT INCLUDE: ENHANCED SUPERVISION FRAMEWORK: DEVELOPMENT OF A ROBUST SUPERVISION CURRICULUM FOR BOTH MSW STUDENTS AND CLINICAL SUPERVISORS; EDUCATIONAL SESSIONS FOR CLINICAL SUPERVISORS IN THE REGION TO ENSURE QUALITY PRACTICE IN COMMUNITY MENTAL HEALTH ORGANIZATIONS; POST-GRADUATION OPPORTUNITIES FOR CLINICAL SUPERVISION TO SUPPORT LICENSURE ATTAINMENT. PROFESSIONAL DEVELOPMENT: A PREPARATORY COURSE FOR STUDENTS TO OBTAIN LICENSURE; GUIDED INSTRUCTION FOR OBTAINING AN NPI NUMBER, A PROGRAM REQUIREMENT; CONTINUING EDUCATION IN INTERDISCIPLINARY AND IC TEAMS FOR FIELD SITE SUPERVISORS TO ENHANCE INTEGRATED SERVICE DELIVERY AND STREAMLINE PATIENT CARE. DIVERSE CLINICAL CASELOADS: USING VIRTUAL TRAINING TO EXPOSE STUDENTS TO DIVERSE CLIENTS, DIAGNOSES, CULTURAL BACKGROUNDS, AND COMPLEX, MULTIFACETED CASES; OPPORTUNITIES FOR STUDENTS TO DEVELOP CRITICAL THINKING AND DECISION-MAKING SKILLS THROUGH SIMULATED AND REAL-WORLD SCENARIOS. ENHANCED SUPPORT FOR EXPERIENTIAL SITES: TARGETED TRAINING AND RESOURCES TO ASSIST EXPERIENTIAL SITES IN ADOPTING IC SYSTEMS AND PROVIDING STREAMLINED, PATIENT-CENTERED SERVICES. THIS PROJECT WILL RECRUIT A DIVERSE GROUP OF 48 STUDENTS OVER THE 4-YEAR GRANT PERIOD, FROM THE MSW PROGRAM AT SOUTHERN ILLINOIS UNIVERSITY CARBONDALE. EACH STUDENT WILL BE ASSIGNED A MENTOR/SITE SUPERVISOR AT ONE OF THE 7 INTEGRATED/INTERDISCIPLINARY SITES. ONCE ACCEPTED, THE MSW FELLOWS WILL ATTEND A DIDACTIC TRAINING EVERY FRIDAY FOR 4 HOURS OVER TWO SEMESTERS. THE HEALING-CENTERED INTEGRATED INTERDISCIPLINARY CURRICULUM IS BUILT ORGANICALLY WITH THE LATEST RESEARCH IN TRAUMA INFORMED EVIDENCE BASED CLINICAL PRACTICES. TO FORTIFY THE MSW TFS PROFESSIONAL GROWTH AND CLINICAL SUCCESS, A HEALING-CENTERED INTEGRATED INTERDISCIPLINARY CLINICAL SUPERVISION TRAINING. WITH ADDITIONAL GROUP CONSULTATION. WILL BE A RESOURCE FOR THE SITE SUPERVISORS, WHO WILL MEET QUARTERLY FOR CONSULTATION. ADDITIONAL PROFESSIONAL DEVELOPMENT ENHANCEMENT FOR GRADUATING STUDENTS INCLUDE A LICENSING PREP COURSE AND CONNECTION TO EMPLOYMENT OPPORTUNITIES IN THE MEDICAL UNDERSERVED REGION OF SOUTHERN ILLINOIS. THIS WILL INCREASE THE SUPPLY OF A DIVERSE BH WORKFORCE WHO ARE TRAINED TO PROVIDE INTEGRATED CARE IN RURAL SOUTHERN ILLINOIS WHICH AIMS TO IMPROVE PATIENT CARE AND HEALTH EQUITY. THIS PROJECT MEETS THE QUALIFICATIONS FOR A FUNDING PRIORITY AND PREFERENCE. (ATTACHMENT 8)

15-LIPOXYGENASE-2 (ALOX15B) AS A TUMOR SUPPRESSOR

HEALTH CENTER CORONAVIRUS AID, RELIEF, AND ECONOMIC SECURITY (CARES) ACT FUNDING

CONGRESSIONALLY DIRECTED SPENDING FOR CONSTRUCTION PROJECTS

PRIMARY CARE TRAINING AND ENHANCEMENT -- RESIDENCY TRAINING IN STREET MEDICINE - THE PROPOSED SOUTHERN ILLINOIS UNIVERSITY (SIU) SCHOOL OF MEDICINE PROJECT IS ENTITLED PRISM – PREPARING RESIDENTS IN STREET MEDICINE – SEEING HOMELESS CARE THROUGH A NEW LENS IN CENTRAL AND SOUTHERN ILLINOIS. THE PURPOSE OF THIS PROJECT IS TO PREPARE SIU FAMILY MEDICINE RESIDENTS ACROSS THREE RESIDENCY SITES IN CENTRAL AND SOUTHERN ILLINOIS – ONE SUBURBAN AND TWO RURAL - TO DELIVER HIGH QUALITY, INNOVATIVE CARE TO INDIVIDUALS EXPERIENCING HOMELESSNESS IN THEIR COMMUNITIES AS WELL AS THE KNOWLEDGE, LEADERSHIP, AND INTER-PROFESSIONAL COLLABORATION SKILLS NEEDED TO ADAPT THIS CARE TO THEIR FUTURE PRACTICE COMMUNITIES. FAMILY MEDICINE RESIDENTS WILL GAIN EXPERTISE IN THE UNIQUE CHALLENGES OF CHRONIC DISEASE MANAGEMENT, SUBSTANCE USE DISORDER, AND MENTAL HEALTH THROUGH A ROBUST EXPANSION OF DIDACTICS AND COMMUNITY PARTNERSHIPS AS WELL AS DIRECT HANDS-ON EXPERIENTIAL LEARNING WITH SIU FACULTY USING STATE-OF-THE-ART SIMULATIONS AND CLINICAL ROTATIONS. FAMILY MEDICINE RESIDENTS WILL HAVE THE OPPORTUNITY TO BUILD ON THEIR SKILLS THROUGH DIRECT CARE OF INDIVIDUALS EXPERIENCING HOMELESSNESS AS A MEMBER OF THE SIU STREET MEDICINE TEAM. THIS INNOVATIVE TEAM WILL ALLOW RESIDENTS TO LEARN FIRSTHAND THE CHALLENGES OF CARE DELIVERY IN A NONTRADITIONAL MODEL THROUGH AD HOC STREET BASED CLINICAL CARE AS WELL AS THE IMPORTANCE OF INTER-PROFESSIONAL AND COMMUNITY COLLABORATION AS THEY PROVIDE DIRECT SERVICE TO THE NEARLY 800 INDIVIDUALS EXPERIENCING HOMELESSNESS ACROSS THREE RESIDENCY SITES IN A MIXTURE OF SUBURBAN AND RURAL CARE SETTINGS. THIS PROJECT REQUESTS CONSIDERATION FOR FUNDING PRIORITY BY TRAINING RESIDENTS IN RURAL AREAS AND ALSO FOR FUNDING PREFERENCE DUE TO PLACING 67% OF THE LAST 2 YEARS OF GRADUATES IN MEDICALLY UNDERSERVED COMMUNITIES.

CONGRESSIONALLY DIRECTED SPENDING FOR CONSTRUCTION PROJECTS