Northshore University Healthsystem

PSYCHOSOCIAL INTERVENTION, MATERNAL INFLAMMATION, AND BIRTH OUTCOMES: CENTERING VS. ROUTINE PRENATAL CARE (PIINC) STUDY

MODELING ALZHEIMER'S DISEASE GENETIC VARIANTS IN HIPSC

MOLECULAR EPIDEMIOLOGY OF PARKINSON'S DISEASE

A NOVEL DATA SCIENCE AND NETWORK ANALYSIS APPROACH TO QUANTIFYING FACILITATORS AND BARRIERS OF LOW TIDAL VOLUME VENTILATION IN AN INTERNATIONAL CONSORTIUM OF MEDICAL CENTERS

TARGETING INTERINDIVIDUAL VARIABILITY IN NSAID RESPONSES TO MITIGATE CHRONIC PELVIC PAIN RISK IN DYSMENORRHEA - MENSTRUAL PAIN (DYSMENORRHEA) IS A MAJOR CAUSE OF DISTRESS, DISABILITY, AND DEVELOPMENT OF CHRONIC PELVIC PAIN (CPP). VERY LITTLE IS KNOWN ABOUT HOW LOCAL UTERINE INFLAMMATION AND CENTRAL NEURAL DYSREGULATION INTERACT TO CAUSE PAINFUL PERIODS. UNDERSTANDING THEIR INTERACTION AND HOW IT MIGHT WORSEN CENTRAL NEURAL HYPERSENSITIVITY IS ESSENTIAL TO PREVENT DYSMENORRHEA FROM PROGRESSING INTO CPP CONDITIONS LIKE BLADDER PAIN SYNDROME, IRRITABLE BOWEL SYNDROME, OR ENDOMETRIOSIS. THERE ARE TWO FACTORS IN DYSMENORRHEA WE HAVE STUDIED THAT HOLD PROMISE AS TARGETS TO REDUCE FUTURE RISK OF CPP – THE PRESENCE OF CO-OCCURRING BLADDER HYPERSENSITIVITY AND THE INDIVIDUAL RESPONSE TO COMMON ANTI-INFLAMMATORY TREATMENTS. THE EXPANSION OF PAIN FROM ONE PELVIC ORGAN TO NEARBY ONES SUGGESTS SENSORY PROCESSING DYSREGULATION IN THE SPINAL CORD OR BRAIN. OUR PRELIMINARY DATA SHOWS THAT EFFECTIVE NSAID THERAPY FOR DYSMENORRHEA MAY REDUCE FUTURE CPP RISK BY NORMALIZING LOCAL NERVE ACTIVATION, INFLAMMATORY MOLECULES IN THE UTERINE LINING, AND PAINFUL HYPERSENSITIVITY IN ADJACENT PELVIC ORGANS. TO DISTINGUISH THE ROLE OF DIFFERENT SENSORY MECHANISMS IN CPP PROGRESSION, OUR INTERDISCIPLINARY TEAM WILL USE A COLLECTION OF VALIDATED SENSORY TASKS INVOLVING MECHANICAL, THERMAL, ELECTRICAL STIMULATION AND BLADDER FILLING. OUR PROPOSAL ALSO PAIRS HIGH-DENSITY ELECTROENCEPHALOGRAPHY WITH SENSORY TESTING TO IDENTIFY BRAIN DIFFERENCES RELATED TO ABNORMAL PAIN INTERPRETATION. WE PLAN TO ADMINISTER THESE TASKS ALONG WITH SYMPTOM QUESTIONNAIRES TO UNDERSTAND WHY SOME WOMEN WITH MENSTRUAL PAIN RESPOND BETTER TO NSAIDS, AND WHICH FACTORS PREDICT DIMINISHED CPP RISK FOLLOWING AN OPTIMIZED PROGRAM TO REDUCE MENSTRUAL PAIN. IN AIM 1 WE WILL CONDUCT A ONE- YEAR, RANDOMIZED CONTROLLED TRIAL (N=300) OF OPTIMIZED NSAID VS. PLACEBO TREATMENT FOR PERIOD PAIN IN MODERATE-PLUS DYSMENORRHEA SUFFERERS. WE WILL DETERMINE WHETHER ACTIVE TREATMENT, MENSTRUAL PAIN RELIEF, AND LOWER LEVELS OF UTERINE INFLAMMATORY MOLECULES PREDICT LOWER NONMENSTRUAL PELVIC PAIN (NMPP, A MARKER FOR FUTURE CPP RISK) AT ONE YEAR POST-TREATMENT. AIM 2, CONDUCTED WITHIN THE AIM 1 STUDY STRUCTURE, WILL ESTABLISH WHICH SPECIFIC SENSORY TESTS PREDICT REDUCTIONS IN NMPP FOLLOWING TREATMENT. EEG WILL BE USED TO PINPOINT PRECISE MECHANISMS FOR DIFFERENCES IN THESE SENSORY RESPONSES. COLLECTIVELY, THIS STUDY OF HIGHER-RISK WOMEN IS DESIGNED TO CHARACTERIZE HOW MENSTRUAL PAIN AND BLADDER HYPERSENSITIVITY INTERACT TO PROMOTE CPP, AND IF THESE FACTORS PREDICT WHO BENEFITS FROM EARLY PREVENTATIVE TREATMENT. THE APPROACH IS NOVEL FOR USING A SAMPLE OF WOMEN ENRICHED FOR FUTURE PAIN RISK (WOMEN WITH DYSMENORRHEA AND BLADDER PAIN) AND FOR CONDUCTING FUTURE PAIN-RISK PREDICTION WITH RECOGNIZED FACTORS: SENSORY TESTING PROFILES, ADJACENT ORGAN PAIN INVOLVEMENT, AND OBSERVED RESPONSE TO A TARGETED TREATMENT. STRUCTURAL EQUATION MODELING WILL BE USED TO FORMALLY DEFINE HOW THESE INTERACT TO CAUSE CPP WHILE CONTROLLING FOR OTHER KEY PAIN RISK FACTORS, SUCH AS RELATIVE LOCAL INFLAMMATION AND PSYCHOSOCIAL PROFILES. THESE STUDY RESULTS OBTAINED BY A DIVERSE TEAM OF INTERDISCIPLINARY COLLABORATORS ARE EXPECTED TO MARKEDLY IMPROVE OUR UNDERSTANDING OF PAIN RISK HETEROGENEITY FOR CHRONIC PAIN PREVENTION

INTEGRATING EPIGENOMICS WITH DNA BREATHING DYNAMICS FOR HUMAN NON-CODING DISEASE VARIANTS

ANESTHESIA-INDUCED LEARNING DEFICIENCY AND BRAIN HYPEROXIA

FEMALE SEXUAL ORIENTATION GWAS

COMMUNITY CHILD HEALTH NETWORK-LAKE COUNTY, IL

1/2 AN INTEGRATIVE GENETIC INVESTIGATION OF SCHIZOPHRENIA

A GENOME-WIDE ASSOCIATION STUDY OF SCHIZOPHRENIA

COMMUNITY CLINICAL ONCOLOGY PROGRAM

LONGITUDINAL CHANGES IN THE INTRA-RENAL OXYGENATION BY BOLD MRI IN PATIENTS WITH

INFLAMMATORY PATHWAYS IN BPH/LUTS

VITAMIN D AND PROGESTINS FOR THE CHEMOPREVENTION OF FALLOPIAN TUBE/OVARIAN CANCER

GENE EXPRESSION IN AN AFRICAN AMERICAN SCHIZOPHRENIA DATASET

PROJECT DESCRIPTION: ENDEAVOR HEALTH AIMS TO DEVELOP AND IMPLEMENT A HOSPITAL-BASED COMMUNITY VIOLENCE INTERVENTION PROGRAM, ENDEAVOR TO HEAL, AT THREE OF THEIR EIGHT HOSPITALS ON CHICAGO, ILS NORTH SIDE AND NORTH SUBURBS (SWEDISH HOSPITAL, EVANSTON HOSPITAL AND HIGHLAND PARK HOSPITAL). THE ENDEAVOR TO HEAL PROGRAMS GOAL IS TO DECREASE INSTANCES OF VIOLENT INJURY WITHIN HIGH-CRIME NEIGHBORHOODS IN THE ENDEAVOR HEALTH SERVICE AREA, THEREBY CONTRIBUTING TO AN OVERALL REDUCTION IN VIOLENT CRIME IN CHICAGO, AND ITS SURROUNDING SUBURBS BY USING A SYSTEMATIC APPROACH THAT INCORPORATES COLLABORATIVE PARTNERSHIPS, COMMUNITY ENGAGEMENT, AND EVIDENCE-BASED VIOLENCE PREVENTION AND INTERVENTION METHODS. THE CORE STRATEGIES TO MEET THESE OBJECTIVES INCLUDE: RAPID RESPONSE AND CRISIS INTERVENTION, INTENSIVE CASE MANAGEMENT, MENTAL HEALTH SERVICES, HOSPITAL-COMMUNITY COLLABORATION, AND WORKFORCE DEVELOPMENT. ENDEAVOR TO HEAL DEFINES THE TARGET POPULATION AND HIGH-RISK INDIVIDUALS (ADULTS AND YOUTH OVER THE AGE OF 16) AS THOSE WHO HAVE EXPERIENCED VIOLENT INJURY, SUCH AS GUNSHOT WOUNDS, STABBINGS, OR PHYSICAL ASSAULT, AND ARE ADMITTED TO ONE OF THE THREE PARTICIPATING HOSPITALS. THE PROGRAM WILL ALSO CONSIDER INDIVIDUALS WITH A HISTORY OF VIOLENT VICTIMIZATION OR INVOLVEMENT IN COMMUNITY VIOLENCE TO BE AT HIGH RISK. ENDEAVOR HEALTH HAS SUBSTANTIAL EXPERIENCE WORKING DIRECTLY WITH SURVIVORS OF VIOLENCE THROUGH BOTH MEDICAL INTERVENTION AND PROGRAMMATIC INITIATIVES AIMED AT PREVENTION AND INTERVENTION AND WILL BUILD SUPPORTIVE SERVICES FOR VICTIMS OF VIOLENT INJURY THROUGH INDIVIDUALIZED TREATMENT PLANS, ACCESS TO INDIVIDUAL AND GROUP THERAPY, ENGAGEMENT IN COMMUNITY-BASED AGENCIES DEDICATED TO ADDRESSING SOCIAL DETERMINANTS AND EQUITY IN CARE, AND OTHER SERVICES AIMED AT REDUCING RISK OF REINJURY. THE ENDEAVOR TO HEAL PROGRAM WILL ADDRESS HEALTHCARE DISPARITIES ACROSS THE CARE CONTINUUM THROUGH PARTNERSHIP WITH COMMUNITY ORGANIZATIONS THAT SHARE OUR VISION TO IMPROVE EQUITABLE HEALTH OUTCOMES AND WILL CONDUCT A PROCESS AND OUTCOMES EVALUATION TO ASSESS PROGRAMMATIC SUCCESS.

MOLECULAR CONTROL OF EGF RECEPTOR DOWN-REGULATION

ANTI-INFECTIVE STEWARDSHIP USING THE WISCA TOOL IN THE ELECTRONIC MEDICAL RECORD

JOINT MAPPING OF GENOME-WIDE GENE EXPRESSION AND ASSOCIATION IN A SCHIZOPHRENIA D

NONENHANCED 3T QISS MR ANGIOGRAPHY OF THE PERIPHERAL ARTERIES

RAPID REAL-TIME MR ANGIOGRAPHY OF SUSPECTED STROKE

BOLD MRI: APPLICATION TO INTRARENAL OXYGENATION

NON-CONTRAST MAGNETIC RESONANCE ANGIOGRAPHY OF PERIPHERAL VASCULAR DISEASE

TOLL-LIKE RECEPTOR SIGNALING IN THE PATHOGENESIS AND PREVENTION OF PREMATURITY

SPINAL SEROTONIN IN CEREBRAL PALSY

PRE-PROCEDURAL EVALUATION OF HIGH-RISK PATIENTS USING NEXT-GENERATION RADIAL QISS

DETECTION, EDUCATION, RESEARCH AND DECOLONIZATION WITHOUT ISOLATION IN LONG-TERM

PREVENTION OF PRETERM BIRTH USING THE COLLECTIN SURFACTANT PROTEIN A (SP-A)

AP-1 FACTORS IN THE PATHOGENESIS AND PROGRESSION OF BENIGN PROSTATIC HYPERPLASIA

2/2 TARGETED SEQUENCING AND FUNCTIONAL EVALUATION OF MUTATIONS IN SCHIZOPHRENIA

PERINATAL WHITE MATTER DEVELOPMENT AND FETAL HYPOXIA

TARGETING RACIAL DISPARITIES IN STROMAL DGAT TO SUPPRESS AGGRESSIVE PROSTATE CANCER

HIPPOCAMPAL MICROSTRUCTURE AND FUNCTION IN APP TG MICE

ONCOLYTIC ADENOVIRUS-STGFBETARIIFC TARGETING BREAST CANCER BONE METASTASIS

DIAGNOSTICS FOR RAPID TREATMENT AND CONTROL OF MULTIDRUG-RESISTANCE IN HEALTHCARE

DNA DAMAGE CHECKPOINT AND CANCER

THE ROLE OF MUTATIONS IN BRCA2 AND OTHER KNOWN AND NOVEL CANCER SUSCEPTIBILITY GENES IN INHERITED RISK FOR LETHAL PROSTATE CANCER

MOLECULAR MECHANISM OF GRANULE-MEDIATED APOPTOSIS

MCH RESEARCH

5/5-THE PSYCHIATRIC GWAS CONSORTIUM: INTEGRATED & COORDINATED GWAS META-ANALYSES

ANTI-ANGIOGENIC BARRIERS TO TUMOR DEVELOPMENT

PAF RECEPTOR TRAFFICKING AND FUNCTION IN EPITHELIAL CELLS

INTRARENAL OXYGENATION: AN EARLY MARKER FOR RISK OF DEVELOPING AKI

THE ROLE OF PAF AND TLR IN NEC

LEUKOCYTIC PHENOTYPES ASSOCIATED WITH BPH PROGRESSION

SWEDISH HOSPITAL SANE PROGRAM EXPANSION

OPTIMIZING UTILIZATION OF LAY HEALTH WORKERS TO ADDRESS MATERNAL AND CHILD HEALTH DISPARITIES: A COMPREHENSIVE EVALUATION OF A CLINICALLY INTEGRATED BREASTFEEDING PEER COUNSELING PROGRAM - BREASTFEEDING PROVIDES UNIQUE AND PROFOUND MATERNAL AND INFANT HEALTH BENEFITS. IF 90% OF US PARENT- INFANT DYADS BREASTFED EXCLUSIVELY FOR THE FIRST SIX MONTHS AND SUPPLEMENTED THROUGH 12 MONTHS, 2600 EXCESS MATERNAL DEATHS AND 721 INFANT DEATHS COULD BE AVERTED EACH YEAR. DESPITE THESE SUBSTANTIAL HEALTH BENEFITS CONFERRED BY BREASTFEEDING, ONLY 45% OF US BIRTH PARENTS MEET THIS 6-MONTH GOAL, AND PARENTS OF COLOR AND THOSE IN LOW INCOME FAMILIES FACE ADDITIONAL BARRIERS TO BREASTFEEDING SUCCESS, RESULTING IN DOUBLE THE RISK OF INFANT MORBIDITY AND MORTALITY. CLINICALLY-INTEGRATED BREASTFEEDING PEER COUNSELING (CI-BPC) HAS BEEN SHOWN TO EFFECTIVELY PROMOTE RACIAL AND ECONOMIC EQUITY IN BREASTFEEDING OUTCOMES. DESPITE THE DEMONSTRATED EFFECTIVENESS OF CI-BPC, THERE REMAIN CRITICAL KNOWLEDGE GAPS REGARDING PROGRAM DESIGN AND COSTS. THUS, THE SCIENTIFIC OBJECTIVE OF THIS K01 APPLICATION IS TO EVALUATE THE IMPLEMENTATION OF AN EFFECTIVE CI-BPC PROGRAM AND DETERMINE THE ESSENTIAL PROGRAM ACTIVITIES, IDENTIFY SIGNIFICANT PATIENT-LEVEL AND CONTEXTUAL FACTORS RELEVANT TO IMPLEMENTATION, AND DETERMINE THE ECONOMIC IMPACT OF CI-BPC FOR PATIENTS, HEALTH SYSTEMS, AND SOCIETY. CLOSING THESE GAPS IN KNOWLEDGE WILL SUPPORT WIDER ADOPTION OF CI-BPC BY PROVIDING A FRAMEWORK FOR IMPLEMENTATION AND EVALUATION. MY CENTRAL HYPOTHESIS IS THAT CI-BPC COUNSELLING INCREASES PATIENT BREASTFEEDING KNOWLEDGE AND SOCIAL SUPPORT, LEADING TO INCREASED EMPOWERMENT AND REDUCED STRESS, AND THAT THE IMPROVEMENTS IN BREASTFEEDING RATES CONFERRED BY CI-BPC WILL BE ASSOCIATED WITH LOWER COST OF HEALTHCARE UTILIZATION FOR INFANTS IN THE FIRST 6 MONTHS POST-DELIVERY. SPECIFICALLY, I AIM: (1) TO DETERMINE THE ESSENTIAL PROGRAM ACTIVITIES OF AN EFFECTIVE HOSPITAL CI-BPC PROGRAM, IDENTIFY RELEVANT CONTEXTUAL FACTORS, AND ADAPT THE PROGRAM TO OPTIMIZE BREASTFEEDING OUTCOMES FOR BLACK AND LATINX PATIENTS; (2) TO DETERMINE WHETHER THE ADAPTED CI-BPC PROGRAM IS MORE EFFECTIVE AT IMPROVING BREASTFEEDING OUTCOMES, ATTITUDE, KNOWLEDGE, AND SUPPORT COMPARED TO STANDARD PRENATAL CARE, AND (3) TO DETERMINE PATIENT, PROGRAM, HEALTHCARE, AND SOCIETAL COSTS FOR CI-BPC. THIS PROJECT WILL EVALUATE AN INNOVATIVE HOSPITAL-BASED CI-BPC PROGRAM AT NORTHSHORE UNIVERSITY HEALTHSYSTEM THAT HAS DEMONSTRATED SIGNIFICANT REDUCTION IN BREASTFEEDING DISPARITIES. MY INTIMATE ROLE WITH THIS CI-BPC PROGRAM AND MY EXPERTISE IN MIXED-METHODS FIELD-BASED AND CLINICAL RESEARCH HAS EQUIPPED ME WITH THE SKILLS TO UNDERTAKE SUCH A PROJECT, BUT I NEED ADDITIONAL MENTORSHIP AND TRAINING IN IMPLEMENTATION SCIENCE, CLINICAL INTERVENTION RESEARCH, AND HEALTHCARE ECONOMICS. THE TRAINING AND RESEARCH ARE SIGNIFICANT BECAUSE DISPARITIES IN MATERNAL AND CHILD HEALTH IN THE US ARE GROWING, AND AN EVIDENCE-BASIS IS ESSENTIAL TO REPLICATE AND SCALE UP INTERVENTIONS THAT PROMOTE HEALTH EQUITY. THIS INNOVATIVE RESEARCH WILL GENERATE NOVEL DATA REGARDING CI-BPC PROGRAM DESIGN AND ECONOMIC IMPACT OF CI-BPC THAT WILL INFORM BROADER IMPLEMENTATION OF THIS INTERVENTION. THIS APPLICATION IS RESPONSIVE TO SEN NOT-HS-21-014: AHRQ ANNOUNCES INTEREST IN HEALTH SERVICES RESEARCH TO ADVANCE HEALTH EQUITY.

NOVEL PELVIC FLOOR PAIN MEASURES TO ENHANCE FEMALE PELVIC PAIN EVALUATION

MITOCHONDRIA, SUPEROXIDE & MNSOD IN A FETAL HYPOXIC CEREBRAL PALSY MODEL

ROLE OF INTERNEURONS IN RESTING STATE FMRI CONNECTIVITY DURING NORMAL DEVELOPMENT AND AFTER PERINATAL BRAIN INJURY

NEURONAL NITRIC OXIDE SYNTHASE IN EARLY CRITICAL FETAL BRAIN INJURY FROM HYPOXIA

THE PSYCHOSOCIAL & GENETIC BASIS OF ESTROGEN METABOLISM & BLOOD PRESSURE IN AGING

TRANSLATOME PROFILING OF NICOTINE ADDICTION

INTRA-RENAL BOLD MRI: APPLICATION TO DIABETIC NEPHROPATHY

PROJECTION IMAGING OF PERIPHERAL VASCULAR CALCIFICATIONS

META-ANALYSIS OF MALE SEXUAL ORIENTATION

DETECTION OF HOST RESPONSE IN CLOSTRIDIUM DIFFICILE INFECTION

ROLE OF GUT MICROBIOTA IN SUSCEPTIBILITY OF PRETERM INFANTS TO HYPOXIC BRAIN INJURY

NONINVASIVE IMAGING OF UTERINE PHYSIOLOGY TO IMPROVE TREATMENT FOR DYSMENORRHEA

IN VIVO FRACTIONAL BLOOD VOLUME: CONTRIBUTIONS TO RENAL BOLD MRI. - OUR LABORATORY HAS PIONEERED THE USE OF BLOOD OXYGENATION LEVEL DEPENDENT (BOLD) MRI THE KIDNEYS AS A WAY OF EVALUATING ITS OXYGENATION STATUS. SEVERAL INVESTIGATORS AROUND THE WORLD HAVE VALIDATED THE TECHNIQUE. HOWEVER, IT REMAINS AS A QUALITATIVE MEASURE AND ITS SPECIFICITY TO OXYGENATION IS NOT VALIDATED. EVEN THOUGH IT IS KNOWN THEORETICALLY THAT A ROLE EXISTS FOR THE FRACTIONAL BLOOD VOLUME (FRACTION OF THE TISSUE OCCUPIED BY BLOOD VESSELS) IN BOLD MRI, WITH THE LACK OF DATA IT HAS BEEN TACITLY ASSUMED TO BE EITHER SMALL OR NON-EXISTENT. HOWEVER, RECENT DEVELOPMENTS ALLOW US TO MEASURE REGIONAL FBV USING BLOOD POOL CONTRAST AGENTS. HERE, WE WANT TO FOR THE FIRST TIME MEASURE REGIONAL FBV IN HUMAN KIDNEYS AND SEE (I) WHETHER IT IS DIFFERENT IN CORTEX AND MEDULLA; (II) WHETHER MEDULLARY FBV REDUCES WHEN ADMINISTERING FUROSEMIDE AS SUGGESTED BY RECENT DATA IN RAT KIDNEYS; AND (III) WHETHER REGIONAL FBV IS REDUCED IN INDIVIDUALS WITH CHRONIC KIDNEY DISEASE (CKD). IF THE PROPOSED STUDY IS SUCCESSFUL, IT MAY SUPPORT THE USE OF FBV AS AN INDEPENDENT IMAGING MARKER. IN ADDITION, THE DATA WILL HAVE A SIGNIFICANT IMPACT ON THE INTERPRETATION OF RENAL BOLD MRI DATA.

THE INTRA-RENAL OXYGENATION IN CKD AS EVALUATED BY BOLD MRI

A HIGH THROUGHPUT, HUMAN, IN VITRO MODEL OF NEURONAL STRETCH INJURY

GENETIC PERTURBATION OF A SCHIZOPHRENIA SUSCEPTIBILITY LOCUS IN ISOGENIC HUMAN NE

MR-GUIDED ENDOVASCULAR INTERVENTION USING OFF-RESONANCE CONTRAST ANGIOGRAPHY

FAMILIAL FEMALE SEXUAL ORIENTATION PHENOTYPES

MULTI-CHANNEL RECEIVER INTEGRATED WITH RECONFIGURABLE PROCESSORS FOR MRI

NEUROPHYSIOLOGICAL DIAGNOSTICS FOR MENSTRUAL PAIN

IMPROVING FLEXIBLE SIGMOIDOSCOPY IN WOMEN BY OPTICAL ANALYSIS OF MICROVASCULATURE

GENDER SELECTIVITY TO COLON CANCER CHEMOPREVENTION BY NSAIDS

UNDERSTANDING MECHANISMS OF FETAL HYPOXIC BRAIN INJURY RESULTING IN CEREBRAL PALS

DEVELOPING A PREVENTIVE CURE FOR CEREBRAL PALSY

TROPONIN STRUCTURE & FUNCTION IN CARDIOMYOPATHY

MECHANISMS OF VASOACTIVE MEDIATOR ACTION IN FGR

IMPROVING DIAGNOSIS OF HYPERTENSION IN CHILDREN (IDHC)

GYNECOLOGIC CANCER TRANSLATIONAL RESEARCH CENTER OF EXCELLENCE

MECHANISMS OF BPH PROGRESSION

FUNCTIONAL STUDY OF DSS1, A BRCA2 BINDING PROTEIN

9.4T MRI GRADIENTS - THE REQUESTED INSTRUMENT, THE GRADIENT SYSTEM FOR A 9.4T IMAGER, REPRESENTS A SUBSTANTIAL ADVANCEMENT IN THE METHODOLOGY OF TRANSLATIONAL RESEARCH. THIS DEVICE WILL REPLACE THE CURRENT, DEGRADING SYSTEM CURRENTLY IN USE IN THE IMAGER. THE CURRENT GRADIENT IS SUFFERING FROM OVER 15 YEARS OF WEAR, WHICH HAS LED TO THE DETERIORATION OF THE INSULATION MATERIALS THAT SEPARATE THE GRADIENT AND SHIM COILS. CONSEQUENTLY, WE HAVE OBSERVED THAT THE ELECTRICAL COUPLINGS BETWEEN THE GRADIENT AND SHIM COILS CAUSED A SIGNIFICANT DISTORTION IN THE IMAGES PRODUCED. THIS INDICATION, AMONG OTHERS OUTLINED IN THE PROPOSAL BELOW SUGGEST THAT THE CURRENT GRADIENT SYSTEM IS AT INCREASING RISK OF SUDDEN FAILURE WITHOUT ANY WARNING. THE GRADIENT SYSTEM’S INTEGRATED DESIGN WILL BE A COMPLETE AND LASTING FIX FOR THESE ISSUES. FURTHERMORE, IT WILL PERMIT RESEARCHERS TO CONTINUE AND ACCOMPLISH IMPORTANT NIH-FUNDED RESEARCH, THROUGH THE USE OF VARIOUS MAGNETIC RESONANCE (MR) MODALITIES WHICH PROMOTE ROBUST EMPIRICAL FINDINGS. THE PROPOSED PROJECTS THAT WILL UTILIZE THE SYSTEM WILL AIM TO IDENTIFY THE DEVELOPMENTAL AND CELLULAR MECHANISMS OF RESTING STATE FUNCTIONAL MR IMAGING (FMRI) IN HEALTHY STATE AND AFTER PERINATAL BRAIN INJURY, THE MR SIGNATURE OF DEVELOPMENTAL EFFECTS AFTER NEONATAL ANESTHESIA, UNDERSTAND THE PHYSIOLOGY OF VISCERAL PAIN, ETC. AT PRESENT, NORTHSHORE UNIVERSITY HEALTHSYSTEM DOES NOT CURRENTLY POSSESS AN ALTERNATIVE INSTRUMENT CAPABLE OF CONDUCTING THIS TYPE OF RESEARCH EVEN THOUGH THE PI AND THEIR TEAM ALREADY HAS OBTAINED THE NECESSARY EXPERIENCE AND EXPERTISE TO SAFELY AND EFFECTIVELY IMPLEMENT AND OPERATE THE GRADIENT SYSTEM WITH IMMEDIATE EFFECT. THE GRADIENT SYSTEM ALONG WITH THE ENTHUSIASTIC INSTITUTIONAL SUPPORT WILL UNQUESTIONABLY FACILITATE THE PROGRESSION OF RESEARCH IN LINE WITH THE MISSION OF NIGMS AS WELL AS NORTHSHORE UNIVERSITY HEALTHSYSTEM BY ENABLING IMMEDIATE AND IMPACT-DRIVEN RESEARCH TO PRESERVE AND IMPROVE HUMAN LIFE.

NOVEL MOLECULAR TARGET OF COLON CANCER CHEMOPREVENTION BY POLYETHYLENE GLYCOL

RAPID NOVEL MOLECULAR DETECTION OF METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS

NURSE ANESTHETIST TRAINEESHIPS

MRI-COMPATIBLE HIGH RESOLUTION MICROENDOSCOPIC SYSTEM - THE REQUESTED INSTRUMENT, THE OASIS IMPLANT MICROENDOSCOPE, REPRESENTS A REVOLUTIONARY ADVANCEMENT IN THE METHODOLOGY OF TRANSLATIONAL RESEARCH. THE UNIQUE DEVICE IS ENGINEERED IN SUCH A WAY THAT MITIGATES MUCH OF THE LIMITATIONS OF OTHER AVAILABLE IMAGING IMPLANTS. ITS LIGHTWEIGHT AND ELECTRONIC-FREE HEADMOUNT ALLOWS MORE NATURAL BEHAVIOR TO BE EXHIBITED, AS IT IS DESIGNED TO ENABLE THE SUBJECT ANIMAL TO RESPOND AS FREELY AS POSSIBLE TO ITS ENVIRONMENT. FURTHERMORE, IT PERMITS RESEARCHERS TO SIMULTANEOUSLY REPORT DIRECT OBSERVATIONS OF NEURONAL ACTIVATION OBTAINED THROUGH THE IMPLANT MICROENDOSCOPE AND INDIRECT OBSERVATIONS VIA FUNCTIONAL MAGNETIC RESONANCE IMAGING (FMRI). THIS METHOD OF INTERROGATION IS LIKELY TO YIELD INCREDIBLY ROBUST EMPIRICAL FINDINGS. SPECIFICALLY, THE PROPOSED PROJECTS THAT WILL UTILIZE THE DEVICE WILL AIM TO IDENTIFY THE DEVELOPMENTAL AND CELLULAR MECHANISMS OF RESTING STATE FMRI, THE EFFECTS OF NEONATAL ANESTHESIA ON BRAIN TISSUE OXYGEN DYNAMICS, AND UNDERSTAND THE PHYSIOLOGY OF THE RAPHE MAGNUS AND ITS ROLE IN VISCERAL PAIN. AT PRESENT, NORTHSHORE UNIVERSITY HEALTHSYSTEM DOES NOT CURRENTLY POSSESS AN INSTRUMENT CAPABLE OF CONDUCTING THIS TYPE OF RESEARCH EVEN THOUGH THE PI ALREADY HAS OBTAINED THE NECESSARY EXPERIENCE AND EXPERTISE TO SAFELY AND EFFECTIVELY OPERATE THE DEVICE WITH IMMEDIATE EFFECT. THE OASIS IMPLANT MICROENDOSCOPE ALONG WITH THE ENTHUSIASTIC INSTITUTIONAL SUPPORT WILL UNQUESTIONABLY FACILITATE THE PROGRESSION OF RESEARCH IN LINE WITH THE MISSION OF NIGMS AS WELL AS NORTHSHORE UNIVERSITY HEALTHSYSTEM BY ENABLING IMMEDIATE AND IMPACT-DRIVEN RESEARCH TO PRESERVE AND IMPROVE HUMAN LIFE.

IDENTIFYING DIAGNOSTIC PATHWAYS FOR UNDIFFERENTIATED ABDOMINAL PAIN USING ELECTRO

NURSE ANESTHETIST TRAINEESHIPS

NURSE ANESTHETIST TRAINEESHIPS

HERSHEY CONFERENCE ON DEVELOPMENTAL BRAIN INJURY

NURSE ANESTHETIST TRAINEESHIPS

PHASE I TRIAL OF NALTREXONE FOR MESENTERIC PANNICULITIS IND 112251, MAY 4, 2011

NURSE ANESTHETIST TRAINEESHIPS

NURSE ANESTHETIST TRAINEESHIPS

ADVANCED EDUCATION NURSING TRAINEESHIP

NURSE ANESTHETIST TRAINEESHIPS

ADVANCED EDUCATION NURSING TRAINEESHIP

MCH RESEARCH