Illinois Institute Of Technology

NATIONAL CENTER FOR FOOD SAFETY AND TECHNOLOGY

NATIONAL CENTER FOR FOOD SAFETY AND TECHNOLOGY

THE BIOPHYSICS COLLABORATIVE ACCESS TEAM - THE MISSION OF THE BIOPHYSICS COLLABORATIVE ACCESS TEAM (BIOCAT) IS TO PROVIDE USER ACCESS TO A STATE-OF-THE- ART SYNCHROTRON BEAMLINE (18ID) FOR DIFFRACTION AND SCATTERING OF NON-CRYSTALLINE BIOLOGICAL MATERIALS AT THE ADVANCED PHOTON SOURCE, ARGONNE NATIONAL LAB. CONTINUED EVOLUTION OF THE BEAMLINE SINCE FIRST LIGHT IN 1997 HAS RESULTED IN A UNIQUE IN THE USA FIBER DIFFRACTION PROGRAM, AND A WORLD-CLASS BIO-SAXS PROGRAM WITH UNIQUE CAPABILITIES BOTH IN THE EQUILIBRIUM AND TIME-RESOLVED REALMS. THE USE OF SIZE EXCLUSION CHROMATOGRAPHY IN LINE WITH THE SAXS CAMERA HAS ENSURED UNPRECEDENTEDLY HIGH DATA QUALITY EVEN WITH BIOCHEMICALLY CHALLENGING SAMPLES OTHERWISE THOUGHT TO BE INTRACTABLE FOR SAXS. THE RECENT INCORPORATION OF MALS AND DLS IN LINE WITH SEC ALLOWS ADDITIONAL BIOPHYSICAL CHARACTERIZATION THAT CAN BE INVALUABLE IN INTERPRETING SAXS DATA FROM DIFFICULT SYSTEMS. OUR NEW COFLOW SHEATH FLOW SAMPLE CELL HAS REVOLUTIONIZED SAXS DATA ACQUISITION BY PREVENTING RADIATION DAMAGE, ENHANCING EFFICIENCY ACCOMPANIED BY SIGNIFICANT INCREASES IN SIGNAL TO NOISE. BIOCAT MAINTAINS SPECIALIZED APPARATUSES FOR COMBINED TIME-RESOLVED X-RAY DIFFRACTION AND PHYSIOLOGICAL STUDIES OF CARDIAC AND SKELETAL MUSCLE. THESE STUDIES HAVE EXTENDED IN SCOPE FROM BASIC BIOPHYSICAL PROBLEMS TO ADDRESS NEW DISEASE MODELS INCLUDING CARDIOMYOPATHIES. A TRADITIONAL STRENGTH IS FIBER DIFFRACTION OF GENERAL FIBROUS PROTEIN SYSTEMS THAT HAS RECENTLY EXPANDED INTO SCANNING DIFFRACTION IMAGING OF FIBROUS PROTEIN STRUCTURES IN COMPLEX TISSUE SAMPLES. A MAJOR STRENGTH OF THE RESOURCE IS THE EXPERIENCED AND DEDICATED SCIENTIFIC STAFF WHO ASSIST USERS SEVEN DAYS A WEEK IN DATA ACQUISITION, PROCESSING, ANALYSIS AND INTERPRETATION. BIOCAT IS DIRECTED BY DR. THOMAS IRVING, WHO HAS MORE THAN 20 YEARS OF EXPERIENCE OVERSEEING SYNCHROTRON FACILITIES FOR NON-CRYSTALLINE DIFFRACTION AND SCATTERING. DR. JESSE HOPKINS OVERSAW INSTALLATION OF THE NEW COFLOW SAXS SAMPLE CELL, ESTABLISHED NEW USER-FRIENDLY GUI BASED DATA ACQUISITION INTERFACES, AND PROVIDE ADVANCED TOOLS TO INTERPRET SEC-SAXS DATA. DR. HOPKINS DEVELOPS AND MAINTAINS THE BIOXTAS RAW SAXS DATA PROCESSING AND ANALYSIS SOFTWARE PACKAGE AND WILL EXTEND IT TO ALLOW INCREASED AUTOMATION TO OPTIMIZE PRODUCTIVITY WHILE MINIMIZING ON-SITE EFFORT FOR USERS. DR. SRINIVAS CHAKRAVARTHY BIOCAT’S RESIDENT BIOCHEMIST COORDINATES THE SAXS USER PROGRAM, ASSISTS USERS WITH CONDUCTING EXPERIMENTS ON SITE, AND ALSO MAINTAINS THE BIOCHEMICAL INFRASTRUCTURE. DR. WEIKANG MA IS AN EXPERT IN FIBER DIFFRACTION OF MUSCLE AND IS RESPONSIBLE FOR PROVIDING COMPREHENSIVE SUPPORT TO ALL OUR FIBER DIFFRACTION USERS. ALL FOUR OF THESE INDIVIDUALS ARE INVOLVED IN TRAINING AND DISSEMINATION ACTIVITIES, INCLUDING SCIENTIFIC PUBLICATIONS, PRESENTATIONS AT CONFERENCES, ORGANIZATION OF BIOCAT WORKSHOPS AND PARTICIPATING IN COMMUNITY ORGANIZED WORKSHOPS. BIOCAT HAS AN UPDATED WEBSITE WITH A COMPREHENSIVE SET OF INSTRUCTIONS FOR ALL ASPECTS OF THE RESOURCE THAT ARE SUFFICIENT FOR A USER TO PLAN AND EXECUTE SUCCESSFUL EXPERIMENTS AT THE BEAMLINE. TOGETHER THE SAXS AND FIBER DIFFRACTION USER PROGRAMS HOST 70-90 USER GROUPS PER YEAR AND CONSISTENTLY PRODUCE 30-40 PUBLICATIONS PER YEAR.

THE BIOPHYSICS COLLABORATIVE ACCESS TEAM

HIGHER EDUCATION EMERGENCY RELIEF FUND_IHES - CARES ACT - INSTITUTIONAL FUNDS

TAS::89 0328::TAS RECOVERY PROJECT "A WORLD CLASS SMART GRID EDUCATION AND WORKFORCE TRAINING CENTER", NEW RECOVERY AWARD

ILLINOIS INSTITUTE OF TECHNOLOGY CARES ACT HIGHER EDUCATION EMERGENCY RELIEF FUND - IHES

TAS::89 0331::TAS RECOVERY RECOVERY ACT: A WORLD-CLASS UNIVERSITY-INDUSTRY CONSORTIUM FOR WIND ENERGY RESEARCH, EDUCATION, AND WORKFORCE DEVELOP

UNIVERSITY TRANSPORTATION CENTERS

THE PERFECT PROTOTYPE FOR THE ILLINOIS INSTITUTE OF TECHNOLOGY

CLINICAL TESTING OF AN INTRACORTICAL VISUAL PROSTHESIS SYSTEM

THE PERFECT PROTOTYPE FOR THE ILLINOIS INSTITUTE OF TECHNOLOGY

ART: ILLINOIS TECH FORWARD INITIATIVE -THE PROJECT SUPPORTS THE TECHFORWARD INITIATIVE AT ILLINOIS TECH TO FOSTER MARKET-FOCUSED RESEARCH AND DEVELOP A MORE DIVERSE WORKFORCE IN HIGH GROWTH TECHNOLOGY SECTORS. BY ENCOURAGING FACULTY MEMBERS TO COLLABORATE CLOSELY WITH INDUSTRY PROFESSIONALS IN CHICAGO?S TECH ECOSYSTEM AND BUILDING THE INFRASTRUCTURE, CULTURE AND PROCESSES TO SUPPORT THIS, TECHFORWARD AIMS TO INSPIRE FACULTY TO DIRECT THEIR RESEARCH ACTIVITIES TOWARDS ADDRESSING CRITICAL SOCIETAL CHALLENGES. HAVING FACULTY PAIRED WITH INDUSTRY PROFESSIONALS TO TRANSLATE THEIR RESEARCH SHOULD ALSO ENHANCE THE SPEED AND EFFICIENCY OF TECHNOLOGY TRANSFER, ULTIMATELY BENEFITING SOCIETY BY BRINGING INNOVATIONS TO MARKET FASTER. TECHFORWARD WILL ALSO ADDRESS THE ISSUE OF UNDERREPRESENTATION IN THE TECH SECTOR. RECOGNIZING THAT DIVERSITY AND INCLUSIVITY ARE CRITICAL DRIVERS OF INNOVATION AND PROGRESS, TECHFORWARD WILL EXPOSE UNDERREPRESENTED POPULATIONS, INCLUDING FIRST-GENERATION COLLEGE STUDENTS AND OTHER LEARNERS FROM DIVERSE BACKGROUNDS IN THE CHICAGO METROPOLITAN REGION, TO PRACTICAL EXPERIENCES IN COMMERCIALIZATION WITHIN HIGH-GROWTH TECHNOLOGY SECTORS. TECHFORWARD'S FOCUS ON THE RACIAL DIVERSITY OF CHICAGO'S POPULATION IS OF PARTICULAR IMPORTANCE. THE FACT THAT BLACK AND LATINO FOUNDERS REPRESENT ONLY 6% OF TECH FOUNDERS IN THE CITY HIGHLIGHTS A DISPARITY THAT NOT ONLY LIMITS ECONOMIC OPPORTUNITIES FOR UNDERREPRESENTED GROUPS BUT ALSO HINDERS THE TECH SECTOR FROM BENEFITING FROM A WIDER RANGE OF PERSPECTIVES AND TALENTS. ILLINOIS TECH'S LOCATION IN BRONZEVILLE, WHERE 86.6% OF RESIDENTS ARE BLACK, PLACES IT IN A UNIQUE POSITION TO ADDRESS THIS ISSUE DIRECTLY. THIS PROJECT AIMS TO ACCELERATE THE TRANSLATION OF ILLINOIS TECH?S USE-INSPIRED RESEARCH BY LEVERAGING THE EXPERIENCE OF INDUSTRY PROFESSIONALS FROM CHICAGO?S TECH ECOSYSTEM AND THE PROGRAMS AND COMMERCIALIZATION RESOURCES AT ILLINOIS TECH?S ENTREPRENEURSHIP AND INNOVATION HUB TO THE TECHNOLOGY TRANSFER PROCESS. THESE RESOURCES WILL BUILD THE CAPACITY TO DEVELOP A MARKET-DRIVEN PROCESS TO IDENTIFY, ASSESS AND ADVANCE SEED TRANSLATIONAL RESEARCH PROJECTS. TECHFORWARD TARGETS CONVERTING AT LEAST 40% OF THE SEED TRANSLATIONAL RESEARCH PROJECTS INTO COMMERCIAL OPPORTUNITIES AS MEASURED BY NEGOTIATED LICENSES WITHIN 2 YEARS AFTER PROJECTS ARE SELECTED FOR ACCELERATION. THE PROJECT WILL CULTIVATE A DIVERSE POOL OF TALENT WITHIN CHICAGO'S HIGH GROWTH TECHNOLOGY SECTOR BY CREATING EXPERIENTIAL TRAINING PROGRAMS IN RESEARCH COMMERCIALIZATION, DESIGNED FOR BOTH DEGREE-SEEKING STUDENTS AND NON-DEGREE SEEKING UNDERREPRESENTED INDIVIDUALS FROM THE CHICAGO METROPOLITAN REGION. ALL LEARNERS WILL BE TRAINED THROUGH A COMMERCIALIZATION TRAINING PROGRAM, DELIVERED PHYSICALLY OR ONLINE, THEN SOLICITED TO APPLY TO WORK WITH FACULTY AND EXPERIENCED INDUSTRY PROFESSIONALS TO ADVANCE SEED TRANSLATIONAL RESEARCH PROJECTS. BY THE END OF THE PROJECT DURATION, TECHFORWARD WILL HAVE PROVIDED COMMERCIALIZATION TRAINING TO AT LEAST 150 DEGREE SEEKING STUDENTS AND 100 UNDER-REPRESENTED NON-DEGREE SEEKING LEARNERS. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE PLANNED FOR THIS AWARD.

EXPERIMENTAL AND THEORETICAL PARTICLE PHYSICS AT ILLINOIS INSTITUTE OF TECHNOLOGY

COOPERATIVE AGREEMENT FOR RESEARCH, EDUCATION, AND OUTREACH IN SUPPORT OF THE FOOD AND DRUG ADMINISTRATION FOOD SAFETY MODERNIZATION ACT

BIOCAT - BIOPHYSICS COLLABORATIVE ACCESS TEAM

CLINICAL TESTING OF AN INTRACORTICAL VISUAL PROSTHESIS SYSTEM

NATIONAL CENTER FOR FOOD SAFETY AND TECHNOLOGY

ADHERENCE AND EMPOWERMENT: SERVICE PARTICIPATION AND MEANINGFUL OUTCOMES

ARRA INCUBATOR BLDG

CHICAGOLAND ACCELERATOR SCIENCE TRAINEESHIP

THIS COOPERATIVE AGREEMENT IS AWARDED TO ILLINOIS INSTITUTE OF TECHNOLOGY. THIS PROJECT IS A MULTI-INSTITUTIONAL COLLABORATION BETWEEN ILLINOIS TECH (IIT), ARGONNE NATIONAL LABORATORY (ANL), AND RTX CORPORATION. THE GOAL OF THE FULL THREE-YEAR PROJECT IS A PROTOTYPE KWH RECHARGEABLE SOLID-STATE LI-AIR BATTERY (RSS-LAB) WITH GRAVIMETRIC ENERGY DENSITY OF >1000 WH/KG AND VOLUMETRIC ENERGY DENSITY OF >1000 WH/L, A CYCLE LIFE OF 100 ALONG WITH A DETAILED DESIGN OF A MULTI-MWH CELL PACK BASED ON THE RESULTS OF THE PROTOTYPE. FOR A PROJECT ENTITLED, “1K RECHARGEABLE SOLID-STATE LI-AIR BATTERY FOR DECARBONIZING AVIATION”

RAPID DETECTION AND RESPONSE SYSTEMS FOR BIO-DEFENSE

COLLABORATIVE RESEARCH: FRAMEWORKS: IOWARP: BENDING THE I/O FABRIC FOR ADVANCING AI-INFUSED SCIENTIFIC WORKFLOWS -SCIENTIFIC DISCOVERY IS INCREASINGLY DRIVEN BY MASSIVE, COMPLEX DATASETS THAT HOLD THE KEYS TO UNLOCKING NEW KNOWLEDGE AND SOLVING GLOBAL CHALLENGES. HOWEVER, THE CURRENT LANDSCAPE OF DATA STORAGE AND MANAGEMENT IS STRUGGLING TO KEEP PACE WITH THIS DATA DELUGE. IOWARP IS DESIGNED TO CREATE A NEXT-GENERATION DATA MANAGEMENT PLATFORM TAILORED TO THE UNIQUE NEEDS OF MODERN, DATA-INTENSIVE SCIENCE. THIS PLATFORM WILL ADDRESS THE FUNDAMENTAL CHALLENGES THAT RESEARCHERS FACE WHEN DEALING WITH DIVERSE DATA TYPES, THE EXPONENTIAL GROWTH OF DATA, AND THE NEED FOR RAPID ACCESS TO CRITICAL INFORMATION. BY STREAMLINING DATA WORKFLOWS AND ENHANCING DATA ACCESSIBILITY, IOWARP WILL EMPOWER SCIENTISTS AND RESEARCHERS TO FOCUS THEIR VALUABLE TIME AND RESOURCES ON THEIR CORE MISSION: MAKING GROUNDBREAKING DISCOVERIES. BEYOND ITS TECHNICAL ADVANCEMENTS, IOWARP WILL ALSO FOSTER A COLLABORATIVE AND INCLUSIVE RESEARCH ENVIRONMENT, DEMOCRATIZING ACCESS TO DATA AND EQUIPPING THE NEXT GENERATION OF SCIENTISTS WITH ESSENTIAL DATA SKILLS. BY ACCELERATING RESEARCH IN CRITICAL FIELDS LIKE GENOMICS, CLIMATE MODELING, AND AI-DRIVEN DISCOVERY, IOWARP HAS THE POTENTIAL TO UNLOCK TRANSFORMATIVE SOLUTIONS TO GLOBAL CHALLENGES AND DRIVE INNOVATION. THE IOWARP PROJECT WILL ENGINEER A MODULAR, ADAPTABLE, AND SCALABLE DATA MANAGEMENT PLATFORM THAT ADDRESSES THE SPECIFIC CHALLENGES ENCOUNTERED IN MODERN SCIENTIFIC WORKFLOWS, PARTICULARLY THOSE ENHANCED BY ARTIFICIAL INTELLIGENCE (AI) TECHNOLOGIES. IOWARP WILL SIGNIFICANTLY REDUCE DATA ACCESS TIMES, ACCELERATING THE PACE OF SCIENTIFIC DISCOVERY BY HARNESSING STATE-OF-THE-ART TECHNOLOGIES LIKE NVME SSDS, CXL DEVICES, AND CPU-GPU CODESIGNS. IT WILL FOSTER A COLLABORATIVE ECOSYSTEM, INVITING CONTRIBUTIONS FROM DIVERSE SCIENTIFIC AND ENGINEERING COMMUNITIES. BUILDING UPON THE TEAM'S EXTENSIVE EXPERTISE IN MULTI-TIERED STORAGE RESEARCH AND LEVERAGING PRIOR NSF INVESTMENTS IN THIS FIELD, IOWARP WILL INTEGRATE AI-DRIVEN SOLUTIONS TO REDEFINE DATA MANAGEMENT FOR HIGH-PERFORMANCE COMPUTING ENVIRONMENTS. THE ANTICIPATED OUTCOMES OF IOWARP WILL ESTABLISH A THRIVING COMMUNITY-DRIVEN PLATFORM THAT CONTINUALLY EVOLVES TO MEET THE CHANGING NEEDS OF SCIENTIFIC RESEARCH. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE PLANNED FOR THIS AWARD.

PROBING DOSE LIMITS IN CARDIAC SPECT WITH RECONSTRUCTION AND PERSONALIZED IMAGING

PROBING THE STRUCTURE/FUNCTION/DYNAMICS RELATIONSHIP IN BIOMOLECULAR COMPLEXES WITH MULTISCALE COMPUTATIONAL TECHNIQUES

IN-VIVO MRI-BASED PREDICTION OF TDP43 PATHOLOGY IN AGING

OPTIMIZATION OF DIAGNOSTIC ACCURACY, RADIATION DOSE, AND PATIENT THROUGHPUT FOR CARDIAC SPECT VIA ADVANCED AND CLINICALLY PRACTICAL CARDIAC-RESPIRATORY MOTION CORRECTION AND DEEP LEARNING

FRAMEWORK: SOFTWARE: NSCI: COLLABORATIVE RESEARCH: HERMES: EXTENDING THE HDF LIBRARY TO SUPPORT INTELLIGENT I/O BUFFERING FOR DEEP MEMORY AND STORAGE HIERARCHY SYSTEMS

FRAMEWORKS: COLLABORATIVE RESEARCH: CHRONOLOG: A HIGH-PERFORMANCE STORAGE INFRASTRUCTURE FOR ACTIVITY AND LOG WORKLOADS

COMPREHENSIVE LONGITUDINAL PROBABILISTIC ATLAS OF THE BRAIN OF OLDER ADULTS WITHOUT DEMENTIA

2MC: MIDWEST CENTER FOR MICROGRID CYBERSECURITY THE RECIPIENT, ILLINOIS INSTITUTE OF TECHNOLOGY, WILL ESTABLISH 2MC (MIDWEST CENTER FOR MICROGRID CYBERSECURITY). 2MC WILL SUPPORT THE INNOVATION AND TRANSITION OF CYBERSECURITY CAPABILITIES AND HELP IMPROVE THE CYBERSECURITY POSTURE OF THE MIDWEST’S ELECTRICITY DELIVERY SYSTEMS CONCERNING CYBERSECURITY ASPECTS OF THE NETWORKS OF INFORMATION TECHNOLOGY (IT) AND OPERATIONAL TECHNOLOGY (OT). 2MC WILL STRIVE TO EXECUTE THE NATION’S GOAL OF PROTECTING ITS ELECTRIC ENERGY INFRASTRUCTURE FROM CYBER THREATS AND CREATE A MORE RESILIENT ENERGY DELIVERY SYSTEM WITH A FOCUS ON CLEAN ENERGY SYSTEMS, NEXT-GENERATION SMART GRID AND ENERGY MANAGEMENT SYSTEMS PERTAINING TO DISTRIBUTED AND ISLANDABLE MICROGRIDS. 2MC WILL BE A SELF-SUSTAINING ENTITY FOR ADDRESSING INTERRELATED RESEARCH AND DEVELOPMENT AND EDUCATION CHALLENGES OF LAUNCHING THE CYBERSECURITY IN THE ELECTRIC ENERGY INFRASTRUCTURE.

PEER NAVIGATORS FOR THE HEALTH AND WELLNESS OF PEOPLE WITH PSYCHIATRIC DISABILITIES

GROUND EFFECT ON WINGS AND ITS CONTROL IN HIGH SEA STATES [24-000006418]

NEW CLASS OF NUMERICAL OBSERVERS FOR NUCLEAR CARDIOLOGY

CONTROL SYSTEMS FOR ARTIFICIAL PANCREAS USE DURING AND AFTER EXERCISE

PARTICIPATION IN HIGH ENERGY PHYSICS

TAS::89 0321::TAS NON-CARBON MIXED-CONDUCTING MATERIALS FOR PEFC ELECTROCATALYSTS AND ELECTRODES

ANALYZER-BASED PHASE CONTRAST IMAGING SYSTEM DEVELOPMENT AND EVALUATION

NATIONAL CENTER FOR FOOD SAFETY AND TECHNOLOGY

DEVELOPMENT OF A NOVEL CLASS OF ANTIBIOTICS AGAINST VIBRIO CHOLERAE NA+-NQR - PROJECT SUMMARY THE SODIUM-DEPENDENT NADH: UBIQUINONE OXIDOREDUCTASE (NA+-NQR) IS THE MAIN ION TRANSPORTER IN HUNDREDS OF PATHOGENIC BACTERIA, INCLUDING VIBRIO CHOLERAE, THE CAUSAL AGENT OF CHOLERA, A DEVASTATING GASTROINTESTINAL DISEASE WITH A WORLDWIDE DISTRIBUTION THAT HAS DEVELOPED MULTIDRUG-RESISTANT PHENOTYPES. NA+- NQR FULFILLS TWO ESSENTIAL ROLES IN V. CHOLERAE CELL PHYSIOLOGY, AS A RESPIRATORY ENZYME, PROVIDING ENERGY TO THE CELL, AND AS THE MAIN SODIUM PUMP, ENERGIZING THE MEMBRANE AND DRIVING NUTRIENT UPTAKE, PH REGULATION, ELIMINATION OF DRUGS, CELL MOTILITY, SECRETION OF TOXINS AND OTHER HOMEOSTATIC PROCESSES. NA+-NQR IS AN OPTIMAL DRUG TARGET DUE TO ITS CRITICAL ROLE IN BACTERIAL METABOLISM AND BECAUSE IT IS ABSENT IN MAMMALIAN CELLS. MOREOVER, NA+-NQR HAS UNIQUE STRUCTURAL MOTIFS, NOT FOUND IN ANY HUMAN PROTEIN, WHICH ALLOW THE DISCOVERY OF DRUGS THAT CAN ACT SPECIFICALLY ON THIS ENZYME. IN ADDITION, NA+-NQR INHIBITORS COULD INCREASE THE SUSCEPTIBILITY OF V. CHOLERAE TO OTHER DRUGS BY DE-ENERGIZING THE MEMBRANE, AND MAY BE USED IN A COMBINATION DOSING APPROACH TO RESCUE OBSOLETE ANTIBIOTICS. OUR GROUP HAS NOW IDENTIFIED TWO NOVEL COMPOUND LEADS, UBIQUINONE ANALOGS (UQAS) AND PHENOTHIAZINES, AS INHIBITORS OF THIS ENZYME THAT ARE SUITABLE FOR DRUG DEVELOPMENT. THE THREE UQAS ANALOGS CHARACTERIZED HAVE ANTIMALARIAL PROPERTIES AND SHOW SPECIFIC AND POTENT INHIBITORY EFFECTS ON NA+-NQR, WITH STRONG ANTIBIOTIC ACTIVITY AGAINST V. CHOLERAE. THESE COMPOUNDS NOT ONLY ABOLISH V. CHOLERAE NA+-NQR ENZYMATIC ACTIVITY, BUT ALSO TRIGGER THE OVERPRODUCTION OF REACTIVE OXYGEN SPECIES, WHICH IS LETHAL TO MICROBES. THE STRUCTURES OF THESE INHIBITORS AND DOCKING METHODS WERE USED TO IDENTIFY THE PHARMACOPHORE AND THE BINDING MODES OF THE MOLECULES IN THE UQ BINDING SITE, WHICH ALLOW US TO PURSUE LEAD DEVELOPMENT TO OBTAIN INHIBITORS OF HIGH POTENCY AND SPECIFICITY. IN ADDITION, WE HAVE IDENTIFIED THREE PHENOTHIAZINE-LIKE COMPOUNDS WITH ANTI- PSYCHOTIC PROPERTIES THAT SHOW POTENT INHIBITORY ACTIVITY AGAINST NA+-NQR AND THAT COULD BE OPTIMIZED INTO ANTIBIOTICS. THE MAIN AIM OF THIS PROJECT IS THE DEVELOPMENT OF A NOVEL CLASS OF ANTIBIOTICS TO SPECIFICALLY TARGET THE NA+-NQR COMPLEX. THE INHIBITORS THAT WE HAVE IDENTIFIED WILL BE FULLY CHARACTERIZED, TO UNDERSTAND THEIR MECHANISM OF ACTION, BINDING SITES, POTENCY AND ANTIBIOTIC PROPERTIES. MOREOVER, TOXICITY TOWARDS HUMAN CELLS AND MITOCHONDRIA, AS WELL AS THEIR PHARMACOLOGIC PROPERTIES, WILL BE ASSESSED TO EVALUATE THE POTENTIAL OF THESE COMPOUNDS TO TREAT HUMAN INFECTIONS. THE DATA OBTAINED FROM TOXICITY STUDIES, ENZYMATIC AND MICROBIOLOGICAL CHARACTERIZATIONS WILL BE USED TO GUIDE THE DESIGN AND SYNTHESIS OF ANALOGS WITH HIGH POTENCY AND LOW TOXICITY. LEAD OPTIMIZATION WILL BE CARRIED OUT BY OUR MEDICINAL CHEMISTRY TEAM GUIDED BY PHARMACOPHORE ANALYSIS, DOCKING AND BINDING FREE ENERGY CALCULATIONS. THE STRUCTURES OF THE NEWLY-IDENTIFIED INHIBITORS WILL BE USED TO BUILD COMPOUND LIBRARIES CARRYING THE ACTIVE CORE WITH DIFFERENT SUBSTITUTION PATTERNS, WHICH WILL BE ITERATIVELY SCREENED AND CHARACTERIZED. THE DATA GENERATED IN THIS PROPOSAL IS CRITICAL TO THE DISCOVERY OF URGENTLY-NEEDED ANTIBIOTICS WITH A NEW MECHANISM OF ACTION EFFECTIVE AGAINST V. CHOLERAE AND MANY OTHER NA+-NQR BEARING PATHOGENS.

ECONOMIC DEVELOPMENT INITIATIVE, COMMUNITY PROJECT FUNDING, AND MISCELLANEOUS GRANTS

SUPPORTING PATHWAYS FOR ADVANCING READINESS IN COMPUTING: AI, MATHEMATICS, CYBERSECURITY AND STATISTICS -THIS PROJECT WILL CONTRIBUTE TO THE NATIONAL NEED FOR WELL-EDUCATED SCIENTISTS, MATHEMATICIANS, ENGINEERS, AND TECHNICIANS BY SUPPORTING THE RETENTION AND GRADUATION OF HIGH-ACHIEVING, LOW-INCOME STUDENTS WITH DEMONSTRATED FINANCIAL NEED AT ILLINOIS INSTITUTE OF TECHNOLOGY. A TOTAL OF 22 SCHOLARS PURSUING BACHELOR'S AND MASTER'S DEGREES IN ARTIFICIAL INTELLIGENCE, APPLIED MATHEMATICS, COMPUTER SCIENCE, CYBERSECURITY, DATA SCIENCE, OPERATIONS RESEARCH, AND STATISTICS WILL RECEIVE SCHOLARSHIPS AVERAGING $15,000 FOR UP TO FIVE YEARS. SCHOLARS WILL RECEIVE FACULTY AND PEER MENTORING, AND THE PROJECT WILL BUILD STRONG SCHOLAR COHORTS THROUGH EXPERIENTIAL AND INTERDISCIPLINARY LEARNING EXPERIENCES. ADDITIONAL ACTIVITIES FOR SCHOLARS INCLUDE COMMUNITY BUILDING AND CAREER ADVANCEMENT ACTIVITIES. THE OVERALL GOAL OF THIS S-STEM TRACK 2 PROJECT IS TO INCREASE STEM DEGREE COMPLETION OF ACADEMICALLY TALENTED, LOW-INCOME UNDERGRADUATE AND GRADUATE STUDENTS WITH DEMONSTRATED FINANCIAL NEED. THERE IS A SIGNIFICANT NATIONAL NEED TO GROW THE STEM WORKFORCE AND NURTURE KEY TALENT THAT WILL ENSURE ECONOMIC COMPETITIVENESS AND PROVIDE DOMESTIC LEADERSHIP ACROSS CRITICAL SECTORS. THIS PROJECT DIRECTLY SPEAKS TO THIS NEED BY SUPPORTING STEM STUDENT SUCCESS, WHICH WILL STRENGTHEN THE WORKFORCE IN COMPUTING AND OTHER KEY AREAS OF NEED. THE PROJECT WILL BE ASSESSED BY AN EXPERIENCED EVALUATOR THAT WILL PROVIDE TIMELY AND ADAPTIVE FEEDBACK, AND THE DATA GENERATED WILL CONTRIBUTE TO THE KNOWLEDGE BASE REGARDING EFFECTIVE STRATEGIES TO SUPPORT TALENTED, LOW-INCOME STUDENTS IN STEM. THIS PROJECT IS FUNDED BY NSF'S SCHOLARSHIPS IN SCIENCE, TECHNOLOGY, ENGINEERING, AND MATHEMATICS PROGRAM, WHICH SEEKS TO INCREASE THE NUMBER OF ACADEMICALLY TALENTED, LOW-INCOME STUDENTS WITH DEMONSTRATED FINANCIAL NEED WHO EARN DEGREES IN STEM FIELDS. IT ALSO AIMS TO IMPROVE THE EDUCATION OF FUTURE STEM WORKERS, AND TO GENERATE KNOWLEDGE ABOUT ACADEMIC SUCCESS, RETENTION, TRANSFER, GRADUATION, AND ACADEMIC/CAREER PATHWAYS OF LOW-INCOME STUDENTS. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

EFRI C3 SORO: DESIGN PRINCIPLES FOR SOFT ROBOTS BASED ON BOUNDARY CONSTRAINED GRANULAR SWARMS

ILLINOIS INSTITUTE OF TECHNOLOGY: NEW CIRCUITS AWARD. CONTROL NUMBER: 1727-1507 TITLE: ''WIDE BANDGAP SOLID STATE CIRCUIT BREAKERS FOR AC AND DC MICROGRIDS''

FAULT-TOLERANT CONTROL SYSTEMS FOR ARTIFICIAL PANCREAS

PROJECT TITLE '' DIRECT CONVERSION OF FLUE GAS TO VALUE-ADDED CHEMICALS USING A CARBON-NEUTRAL PROCESS.'' THIS PROJECT WILL SUPPORT THE DEVELOPMENT OF THIS NOVEL ELECTROCHEMICAL PROCESS FOR SYNTHESIZING PURE ALCOHOLS, I.E., ETHANOL AND PROPANOL DIRECTLY FROM FLUE GAS THAT CONTAINS VARIOUS COMPONENTS SUCH AS CO2, NOX AND SOX. WE WILL STUDY THE EFFECT OF FLUE GAS COMPOSITION AND OPERATING CONDITIONS ON BOTH THE REACTION KINETICS PARAMETERS AND THE MASS TRANSPORT RATE OF THE FLUE-GAS-BASED CO2 REDUCTION REACTION.

DEGUELIN IN THERAPY OF TRIPLE NEGATIVE BREAST CANCER

TAS::89 0309::TAS ILLINOIS INSTITUTE OF TECHNOLOGY, TITLE: PURIFICATION AND GROWTH INI AND INIXTII-X CRYSTALS FOR NUCLEAR DETECTION APPLICATIONS

EXPANDING THE FREQUENCY WINDOW OF PREDICTIONS FOR THE RESPONSE OF SOFT MATERIAL TO DEFORMATION

NEW BIFUNCTIONAL LIGANDS FOR RADIOIMMUNOTHERAPY

EX VIVO INTRAOPERATIVE SURGICAL BASAL MARGIN ANALYSIS IN HEAD AND NECK CANCER RESECTION: CLINICAL VALIDATION - EX VIVO INTRAOPERATIVE SURGICAL BASAL MARGIN ANALYSIS IN HEAD AND NECK CANCER RESECTION: CLINICAL VALIDATION IN A CLINICAL COLLABORATION WITH THE UNIVERSITY MEDICAL CENTER GRONINGEN (UMCG), NETHERLANDS—LED BY ORAL AND MAXILLOFACIAL SURGEON, DR. WITJES—WE WILL ADVANCE AND CLINICALLY TEST AN INTRAOPERATIVE DUAL-APERTURE FLUORESCENCE RATIO (DAFR) IMAGING SYSTEM AND AN AUTOMATED DATA ANALYSIS (ADA) APPROACH THAT CAN ANALYZE AN ENTIRE RESECTED-TISSUE BASAL MARGIN IN <1 MIN FOR HEAD AND NECK SQUAMOUS CELL CANCER (HNSCC) RESECTION SURGERY. THIS IS A SIGNIFICANT IMPROVEMENT UPON CURRENTLY USED FROZEN-SECTION HISTOPATHOLOGY THAT REQUIRES >30 MIN AND CAN ONLY BE DONE FOR A LIMITED NUMBER OF RESECTED-TISSUE LOCATIONS. THE PROJECT WILL SPECIFICALLY FOCUS ON IMPROVING DETECTION AND LOCALIZATION OF INADEQUATE (POSITIVE AND CLOSE) BASAL SURGICAL MARGINS, CRITICAL FOR PATIENT SURVIVAL. OVER 3 MILLION INDIVIDUALS ACROSS THE GLOBE ARE DIAGNOSED WITH HEAD AND NECK SQUAMOUS CELL CARCINOMA (HNSCC) EACH YEAR. AT PRESENT, SURGICAL INTERVENTION IS THE PRIMARY TREATMENT; HOWEVER, OWING TO THE COMPLEXITY OF THE ANATOMY IN THE HEAD AND NECK, >20% OF PROCEDURES MAY FAIL TO ATTAIN TUMOR-FREE SURGICAL BASAL MARGINS (DEFINED AS GREATER THAN 5 MM OF HEALTHY TISSUE SURROUNDING THE DEEP EDGE OF THE RESECTED TUMOR). UNFORTUNATELY, BECAUSE OF SLOW RESECTED-TISSUE PROCESSING, PATIENTS ARE OFTEN SENT HOME BEFORE MARGINS ARE FULLY ASSESSED. WHILE SOME PATIENTS CAN RETURN FOR RE-RESECTION, FOR MANY, HEALTH CONCERNS OR SUBSTANTIAL POST-RESECTION RECONSTRUCTION SURGERIES MAKE RE-RESECTION INFEASIBLE, AND RADIOTHERAPY AND/OR CHEMORADIOTHERAPY IS NEEDED. PATIENTS WITH INADEQUATE MARGINS HAVE <15% CHANCE OF SURVIVING FOR 5 YEARS POST-SURGERY, COMPARED TO A >80% CHANCE OF SURVIVAL FOR PATIENTS WITH FREE MARGINS AND NO METASTATIC DISEASE. BEFORE DAFR IMAGING AND SURGERY, PATIENTS ARE INJECTED WITH A FLUORESCENT EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR)-TARGETED ANTIBODY, AND INTRAOPERATIVE DAFR IMAGES OF RESECTED BASAL MARGINS ARE TAKEN AND ANALYZED. OUR PRELIMINARY RESULTS FROM A PROOF-OF-CONCEPT DAFR IMAGING SYSTEM INDICATE ALMOST PERFECT DETECTION RATE OF INADEQUATE AS WELL AS CLEAR MARGINS. IN THIS PROJECT, WE PROPOSE NECESSARY IMAGING SYSTEM UPGRADES AND TO DEVELOP AN AUTOMATED DATA ANALYSIS TO REMOVE THE NEED FOR CLINICAL EXPERT MANUAL SEGMENTATION OF IMAGES. THE PROPOSED APPROACH WILL BE VALIDATED AND TESTED AGAINST STATE-OF-THE-ART SURGICAL GUIDANCE METHODS IN AN 80-PATIENT CLINICAL STUDY AT UMCG, IN TERMS OF DETECTION AND LOCALIZATION OF INADEQUATE BASAL MARGINS THROUGH ROC AND LROC ASSESSMENTS.

DIFFERENTIALLY REGULATING APOPTOSIS BY AR: ACTIVATING BAX OR INHIBITING JNK MAPK

CENTER OF ALL-SOLID-STATE BATTERIES FOR A CLEAN ENERGY SOCIETY -PART 1, NON-TECHNICAL REDUCING GREENHOUSE GAS EMISSIONS IS CRITICAL TO ADDRESS THE GRAND CHALLENGE OF CLIMATE CHANGE. RENEWABLE ENERGY INTEGRATION AND VEHICLE ELECTRIFICATION, KEYS TO REDUCING GREENHOUSE GAS EMISSIONS, REQUIRE ENERGY STORAGE AT SCALE WITH SAFETY AND LOW COST. THIS PIRE TEAM WILL CONDUCT FUNDAMENTAL RESEARCH TO ADVANCE SCIENCE AND TECHNOLOGY OF ALL-SOLID-STATE BATTERIES (ASSBS), WHICH HAVE THE POTENTIAL TO TRANSFORM RECHARGEABLE BATTERIES FOR VEHICLE ELECTRIFICATION AND INTEGRATION OF RENEWABLE ENERGY BY OFFERING NEXT-GENERATION ENERGY STORAGE DEVICES WITH HIGHER SPECIFIC ENERGY AT BOTH BATTERY-CELL AND BATTERY-PACK LEVELS, LONGER CYCLE LIFE, LOWER COST AND SUPERIOR SAFETY COMPARED TO LI-ION BATTERIES (LIBS). THE ANTICIPATED ECONOMIC BENEFIT (REDUCTION IN THE COST OF BATTERY PACKS ON THE ENERGY BASE BY 50% OVER LIBS) ALONG WITH UNPRECEDENTED ELECTROCHEMICAL PERFORMANCE (150% INCREASE IN THE SPECIFIC ENERGY) AND INTRINSIC SAFETY WILL USHER IN A NEW ERA OF VEHICLE ELECTRIFICATION AND RENEWABLE ENERGY INTEGRATION FOR A SUSTAINABLE SOCIETY WITH CLEAN ENERGY. BY WORKING WITH INTERNATIONAL PARTNERS FROM 7 INSTITUTIONS IN EUROPE, THE RESEARCHERS WILL ACHIEVE THE CHALLENGING GOAL OF ADVANCING SCIENCE AND TECHNOLOGY IN ASSBS. THROUGH COLLABORATION WITH INDUSTRIAL PARTNERS, THE RESEARCH TEAM WILL EXPEDITE TECHNOLOGY TRANSLATION FROM LABORATORY DISCOVERY TO COMMERCIAL PRODUCTS. FURTHER, THEY WILL COLLABORATE WITH SEVERAL MINORITY-SERVING ELEMENTARY, MIDDLE AND HIGH SCHOOLS IN CHICAGO TO INSPIRE UNDERREPRESENTED MINORITY STUDENTS TO PURSUE STEM EDUCATION AND CAREER. BY WORKING WITH CITY OF CHICAGO, THE RESEARCHERS WILL LAUNCH A WORKFORCE DEVELOPMENT PROGRAM, OFFERING SHORT COURSES AND WORKSHOPS TO MID-CAREER EMPLOYEES AND UNDERREPRESENTED MINORITIES, WHICH CAN ACCELERATE TRANSITION OF THE WORKFORCE INTO CLEAN ENERGY, ELECTRIC VEHICLE, AND ENERGY STORAGE INDUSTRIES. PART 2, TECHNICAL TO ADDRESS THE MULTI-FACETED CHALLENGES FACED BY ASSBS, THE PIS HAVE ASSEMBLED A MULTI-DISCIPLINARY TEAM AND WILL WORK WITH INTERNATIONAL PARTNERS WITH SYNERGISTIC EXPERTISE, PARTICULARLY WITH PROF. BRAGA AT UNIVERSITY OF PORTO, PORTUGAL ? THE INVENTOR OF A NEW SOLID LI-GLASS ELECTROLYTE WITH ULTRAHIGH IONIC CONDUCTIVITY AT ROOM TEMPERATURE (> 10-2 S/CM), WIDE ELECTROCHEMICAL WINDOW (STABLE WITH LI METAL AND RESISTANT TO OXIDATION UP TO 8 V VS. LI/LI+), AND LOW GLASS TRANSITION TEMPERATURE (~75OC). THE TEAM WILL INVESTIGATE AND INTEGRATE CONVENTIONAL AND UNCONVENTIONAL CHARGE STORAGE MECHANISMS TO ACHIEVE ULTRAHIGH SPECIFIC ENERGY, HIGH POWER, LONG CYCLE LIFE ASSBS WITH INTRINSIC SAFETY. ANODE-FREE CELLS WITH LI PLATING/STRIPPING AT BOTH ANODE AND CATHODE ENABLED BY LI-GLASS ELECTROLYTE WILL BE STUDIED FOR THE FIRST TIME. THE ELECTROCHEMICAL PRINCIPLES FOR SUCH LI PLATING/STRIPPING CELLS AND THOSE FOR ANODE-FREE CELLS WITH LI PLATING/STRIPPING AT THE ANODE AND DE/INTERCALATION AT THE CATHODE WILL BE ESTABLISHED TO OFFER GUIDELINES FOR DESIGN OF ASSBS WITH UNPRECEDENTED SPECIFIC ENERGIES. IN-SITU AND EX-SITU CHARACTERIZATIONS WILL BE PERFORMED TO UNRAVEL THE UNDERLYING MECHANISMS CONTROLLING INTERFACIAL PROPERTIES OF ASSBS. DENSITY FUNCTIONAL THEORY CALCULATIONS, MOLECULAR DYNAMICS AND CONTINUUM MODELS WILL BE USED AND INTEGRATED TO ADDRESS THE MULTI-LENGTH SCALE MODELING FROM THE ELECTRODE/ELECTROLYTE INTERFACE TO SINGLE PARTICLE, MULTIPLE PARTICLES, AND EVENTUALLY TO CELL-LEVEL RESPONSES. THE ATOMIC LEVEL, SUB-CONTINUUM LEVEL AND CELL-LEVEL UNDERSTANDINGS DEVELOPED FROM THESE MODELING EFFORTS WILL ASSIST THE FUNDAMENTAL UNDERSTANDING OF CHEMICAL/ELECTROCHEMICAL STABILITY BETWEEN THE ELECTRODE AND LI-GLASS ELECTROLYTE, MECHANICAL CONTACT, LI PLATING/STRIPPING, LI DENDRITE FORMATION, IONIC TRANSPORT, AND DEGRADATION PHYSICS OF ASSBS. THROUGH THESE SCIENTIFIC ADVANCEMENTS, THIS PIRE PROJECT WILL LAY A SOLID FOUNDATION FOR DESIGN, SYNTHESIS AND FABRICATION OF HIGH-PERFORMANCE ASSBS AT SCALE IN THE FUTURE. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

DE-EE0008713, ILLINOIS INSTITUTE OF TECHNOLOGY, DESIGN, OPTIMIZATION, AND CONTROL OF A 100 KILOWATT ELECTRIC TRACTION MOTOR MEETING OR EXCEEDING DOE 2025 TARGETS

HIGH FIDELITY, FASTER THAN REAL-TIME SIMULATOR FOR PREDICTING POWER SYSTEM DYNAMIC BEHAVIOR

ANALYSIS TOOLS FOR FIBER DIFFRACTION OF MUSCLE - SYNCHROTRON SMALL ANGLE X-RAY FIBER DIFFRACTION IS THE METHOD OF CHOICE FOR OBTAINING STRUCTURAL AND PHYSIOLOGICAL INFORMATION IN THE SAME EXPERIMENT FROM ACTIVE MUSCLE. EXPERIMENTAL QUESTIONS ADDRESSED RANGE FROM BASIC BIOPHYSICAL QUESTIONS REGARDING MECHANISMS OF FORCE PRODUCTION AND REGULATION TO INCREASINGLY PRE-CLINICAL QUESTIONS RELATING STRUCTURE TO FUNCTIONAL PHENOTYPE IN ANIMAL MODELS FOR CARDIOMYOPATHIES AND SKELETAL MUSCLE DISEASE AS WELL AS HUMAN MUSCLE BIOPSIES. CRITICAL BARRIERS TO PROGRESS, HOWEVER, HAS BEEN THE LACK OF ROBUST, USER-FRIENDLY TOOLS FOR DATA REDUCTION AND COMPUTATIONAL TOOLS FOR MODELING DIFFRACTION PATTERNS THAT CAN BE USED AS AN AID TO INTERPRET THE DATA. IN AIM 1 WE PROPOSE TO FURTHER DEVELOP THE MUSCLEX SOFTWARE PACKAGE AS A HIGHLY AUTOMATED DATA-REDUCTION SUITE FOR SMALL-ANGLE FIBER DIFFRACTION PATTERNS FROM STRIATED MUSCLE. WE WILL USE ARTIFICIAL INTELLIGENCE (AI) APPROACHES TO GREATLY INCREASE EFFICIENCY, REDUCE INFLUENCE OF OPERATOR BIAS AND IMPROVE REPRODUCIBILITY. NEW FUNCTIONALITY WILL INCLUDE GLOBAL DIFFUSE BACKGROUND SUBTRACTION USING “DEEP LEARNING”, THE ABILITY TO ANALYZE MULTIPLE SUPERIMPOSED DIFFRACTION PATTERNS, AUTOINDEXING AND AUTOMATIC INTEGRATION OF DIFFRACTION PEAKS AND UNSAMPLED LAYER LINES. ROBUSTNESS AND REPRODUCIBILITY OF CODE WILL BE IMPROVED WITH RIGOROUS TESTING AND VALIDATION PROCEDURES. IN AIM 2 WE PROPOSE TO DEVELOP A NEW TOOL, MUSICO-X FOR PREDICTING TWO-DIMENSIONAL X-RAY DIFFRACTION PATTERNS FROM STRIATED MUSCLE. MUSICO-X WILL BE A NEW EXTENSION MODULE FOR THE MULTI-SCALE SIMULATION PACKAGE MUSICO THAT PREDICTS SMALL-ANGLE X-RAY FIBER DIFFRACTION PATTERNS SIMULTANEOUSLY WITH THE PHYSIOLOGICAL DATA AS A NOVEL “FORWARD PROBLEM” APPROACH TO EXTRACTING MAXIMAL INFORMATION FROM STATIC AND DYNAMIC TIME RESOLVED X-RAY FIBER DIFFRACTION EXPERIMENTS ON STRIATED MUSCLE. THIS NEW MODULE WILL ASSIGN ELECTRON DENSITIES TO COMPONENTS OF THE SARCOMERE USING PREDICTED MOLECULAR POSITIONS FROM MUSICO TO PREDICT SIMULATED DIFFRACTION PATTERNS THAT ARE TESTED AND REFINED AGAINST REPRESENTATIVE X-RAY DIFFRACTION AND PHYSIOLOGICAL DATA SETS. THESE PROPOSED SOFTWARE DEVELOPMENTS ARE BROADLY APPLICABLE TO ALL MUSCLE SYSTEMS WITHOUT A SPECIFIC DISEASE FOCUS, AND WOULD NOT BE FUNDABLE THROUGH USUAL MECHANISMS AT NIAMS OR HLBI. THE AVAILABILITY OF ROBUST, USER FRIENDLY DATA REDUCTION CODE WILL INCREASE THE EFFICIENCY AND REPRODUCIBILITY DATA FROM MUSCLE FIBER DIFFRACTION EXPERIMENTS ON MUSCLE. THE PROPOSED NEW SIMULATION TOOL, ENCOMPASSING BOTH THE STRUCTURE AND FUNCTION OF MUSCLE, WILL PROVIDE A POTENT HYPOTHESIS GENERATION AND TESTING TOOL THAT CAN GREATLY INCREASE THE VALUE OF PAST, PRESENT, AND FUTURE X-RAY DIFFRACTION EXPERIMENTS ON MUSCLE.

THIS COOPERATIVE AGREEMENT IS AWARDED TO IIINOIS INSTITUTE OF TECHNOLOGY IS A MULTI-INSTITUTIONAL COLLABORATION BETWEEN ILLINOIS INSTITUTE OF TECHNOLOGY (IIT), GTI ENERGY, TEXAS A&M UNIVERSITY-CORPUS CHRISTI, PROPANE EDUCATION AND RESEARCH COUNCIL (PERC), AND INDUSTRIAL PARTNER SHV ENERGY. THE GOAL IS TO DEMONSTRATE A 5KW PROTOTYPE (4 KG/D EQUIVALENT TO 180 MJ(LHV)/DAY OF PROPANE) USING A SYSTEM OF MULTIPLE CO2 ELECTROLYZER STACKS OPERATING AT UP TO 10-BAR WITH COMPLIMENTARY PROCESS UNITS INCLUDING SEPARATION AND RECYCLE UNITS TO ACHIEVE 97% PROPANE SELECTIVITY, ENERGY TO LIQUID EFFICIENCY OF >50% AND MULTI-PASS CARBON YIELD OF > 85%, PROJECT ENTITLED, “RENEWABLE PROPANE PRODUCTION USING DYNAMIC CO2 ELECTROLYSIS (E-PROPANE)”

ART TRACK 2: GROW: IL-TECHFORWARD -OUR NATION?S LONG-TERM ECONOMIC COMPETITIVENESS AND STAYING AT THE CUTTING EDGE OF TECHNOLOGIES DEPENDS ON THE ABILITY OF UNIVERSITIES TO MOVE RESEARCH DISCOVERIES INTO PRODUCTS, SERVICES, AND VENTURES THAT BENEFIT SOCIETY. ILLINOIS TECH SEEKS TO ENHANCE ITS CAPACITY FOR RESEARCH TRANSLATION BY LAUNCHING AND SCALING IL-TECHFORWARD. THIS PROGRAM WILL CREATE SUSTAINABLE PATHWAYS FOR FACULTY DISCOVERIES TO REACH REAL-WORLD DEPLOYMENT IN NATIONALLY SIGNIFICANT AREAS INCLUDING ENERGY SYSTEMS, CYBERSECURITY, CYBERINFRASTRUCTURE, PRECISION NUTRITION AND FOOD SAFETY, QUANTUM INFORMATION SCIENCE, AND HEALTH INFORMATION TECHNOLOGY. IL-TECHFORWARD LEVERAGES CHICAGO'S INNOVATION ECONOMY THROUGH SEVERAL INDUSTRY PARTNERS. THE PROGRAM ALSO DEVELOPS PROFESSIONAL AND TRANSLATIONAL SCIENCE SKILLS IN GRADUATE SCHOLARS AND POSTDOCTORAL RESEARCHERS. BY DEMONSTRATING HOW SHARED-SERVICES MODELS AND CROSS-INSTITUTIONAL COLLABORATION CAN OVERCOME STRUCTURAL BOTTLENECKS, IL-TECHFORWARD ADVANCES THE NATIONAL INTEREST IN SCIENTIFIC PROGRESS, WORKFORCE DEVELOPMENT, AND ECONOMIC GROWTH. IL-TECHFORWARD IS ANCHORED BY TWO STRATEGIC OBJECTIVES IMPLEMENTED THROUGH A FOUR-YEAR, STAGE-GATED RESEARCH TRANSLATION MODEL. OBJECTIVE 1 BUILDS THE INFRASTRUCTURE FOR BROADER FACULTY PARTICIPATION. IT ADOPTS A TIERED FUNDING FRAMEWORK SPANNING STAGE 1 (PROOF OF CONCEPT), STAGE 2 (MINIMUM VIABLE SOLUTION AND PILOT ENGAGEMENT), AND STAGE 3 (PILOT IN INTENDED-USE ENVIRONMENT). IT ALSO RESTRUCTURES TECHNOLOGY TRANSFER OPERATIONS THROUGH A FRACTIONAL EXPERTISE MODEL DEVELOPED IN PARTNERSHIP WITH THE UNIVERSITY OF ILLINOIS CHICAGO. THIS MODEL INCREASES INTELLECTUAL PROPERTY MANAGEMENT CAPACITY, IMPROVES RESPONSIVENESS, AND DISTRIBUTES LICENSING AUTHORITY TO REDUCE BOTTLENECKS. OBJECTIVE 2 INCREASES THE LIKELIHOOD OF SUCCESSFUL TRANSLATION. IT LAUNCHES INDUSTRY-DRIVEN SEED TRANSLATIONAL RESEARCH PROJECT (STRP) SOLICITATIONS ALIGNED WITH DOCUMENTED PARTNER NEEDS, AND EMBEDS INTERIM BUSINESS EXPERTISE AND STUDENT TALENT INTO RESEARCH TEAMS. BY YEAR 4, THE PROGRAM WILL INCREASE ANNUAL INVENTION DISCLOSURES TO AT LEAST 20, MAINTAIN A MINIMUM OF FIVE ACTIVE INDUSTRY PARTNERS, AND ADVANCE AT LEAST 40% OF FUNDED STRPS TO A DEFINED COMMERCIALIZATION MILESTONE WITHIN TWO YEARS OF INITIAL FUNDING. MILESTONES INCLUDE EXECUTED LICENSES, INDUSTRY PARTNERSHIPS, INVESTMENT, OR SUCCESSFUL CUSTOMER PILOTS. THE PROGRAM WILL ALSO SECURE AT LEAST $5 MILLION IN PHILANTHROPIC, CORPORATE, AND LICENSING REVENUE TO SUSTAIN OPERATIONS BEYOND THE AWARD PERIOD. OVER A TEN-YEAR HORIZON, IL-TECHFORWARD WILL GENERATE A CONTINUOUS PIPELINE OF TRANSLATIONAL RESEARCHERS, INDUSTRY-READY GRADUATES, LICENSED TECHNOLOGIES, AND NEW VENTURES THAT ADVANCE NATIONAL PRIORITIES AND STRENGTHEN U.S. COMPETITIVENESS. THE ART PROGRAM, SUPPORTED BY THE NSF TIP DIRECTORATE, SEEKS TO ADVANCE THE U.S. SCIENTIFIC AND ECONOMIC LEADERSHIP BY BUILDING CAPACITY AND INCREASING THE NUMBER OF ROBUST TRANSLATIONAL RESEARCH ECOSYSTEMS IN INSTITUTIONS OF HIGHER EDUCATION THAT SPAN ACROSS THE FULL GEOGRAPHY OF OUR NATION. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE PLANNED FOR THIS AWARD.

ADVANCED MATERIALS FOR WARFIGHTER PROTECTION: THEORY, COMPUTATION, AND EXPERIMENT

GRADUATE TRAINING FOR FRONTIER RESEARCH USING SYNCHROTRON RADIATION

PROMOTING HEALTHY LIFESTYLE BEHAVIORS TO ADDRESS OBESITY RELATED COMPLICATIONS OF AFRICAN AMERICANS WITH SEVERE MENTAL ILLNESS USING PEER NAVIGATORS

CDI-TYPE II: OPTIMIZATION OF ENGINEERED TISSUE GROWTH BY ACTIVE LEARNING

ENTROPY FOR END-POINT AND FFT-BASED BINDING FREE ENERGY CALCULATIONS

A SUITE OF DIAGNOSTIC AIDS BASED ON IMAGE RETRIEVAL

MANIPULATING MULTISITE ENDOGENOUS BRAIN RHYTHMS DISRUPTS EPILEPTIC SEIZURES

THICK FILAMENT REGULATION MECHANISMS IN HEALTHY AND DISEASED MYOCARDIUM - CARDIOMYOPATHIES ARE A SIGNIFICANT CAUSE OF DEATH AND MORBIDITY WITH LIMITED TREATMENT OPTIONS. A SUBSTANTIAL FRACTION (30-60%) OF THESE CARDIOMYOPATHIES HAS BEEN IDENTIFIED AS “DISEASES OF THE SARCOMERE” HAVING THEIR ORIGIN IN POINT MUTATIONS IN SARCOMERIC PROTEINS LEADING TO DYSREGULATION OF ACTO- MYOSIN INTERACTIONS WITH CONSEQUENT FUNCTIONAL DEFICITS. CURRENT THERAPIES ARE MOSTLY NOT DISEASE SPECIFIC AND FOCUS ON SYMPTOMS RATHER THAN ON MITIGATING THE ROOT CAUSES IN SARCOMERE DYSREGULATION. MUSCLE CONTRACTILITY IS GOVERNED BY BOTH THE CLASSIC AND EXTENSIVELY STUDIED CA2+-MEDIATED THIN FILAMENT- BASED REGULATORY MECHANISM AND NEWLY DISCOVERED, BUT VERY POORLY UNDERSTOOD, THICK FILAMENT BASED REGULATORY MECHANISMS. IN THIS PROPOSAL, OUR OVER-ARCHING HYPOTHESIS IS THAT THICK FILAMENT REGULATORY MECHANISMS ARE CRITICAL MODULATORS OF MUSCLE FUNCTION. IMPROVED UNDERSTANDING OF THESE MECHANISMS WILL IDENTIFY NOVEL DRUG TARGETS, AND THE DESIRED CHARACTERISTICS OF THERAPEUTIC COMPOUNDS, THAT ARE NECESSARY TO MITIGATE THE STRUCTURAL AND FUNCTIONAL DEFECTS UNDERLYING MYOCARDIAL PATHOPHYSIOLOGY. WE HAVE DEMONSTRATED THAT PORCINE MYOCARDIUM, THE CLOSEST MODEL SYSTEM FOR HUMAN HEARTS, IS AN EXCELLENT EXPERIMENTAL SYSTEM FOR OUR PROPOSED STRUCTURAL AND FUNCTIONAL DRIVEN STUDIES, WITH THE EXPECTED FINDINGS READILY EXTRAPOLATABLE TO HUMANS. WE PROPOSE TO INVESTIGATE THE STRUCTURAL, BIOCHEMICAL, AND MECHANICAL ASPECTS OF THICK FILAMENT REGULATION MECHANISMS FROM PORCINE MYOCARDIUM. SPECIFICALLY, IN AIM 1, WE WILL DECOUPLE CLASSICAL CA2+ DEPENDENT THIN FILAMENT-BASED REGULATION FROM THE NEWLY DISCOVERED CA2+ DEPENDENT THICK FILAMENT-BASED REGULATION MECHANISM BY EXCHANGING THE NATIVE TROPONIN COMPLEX WITH EXOGENOUS D65A TROPONIN COMPLEX THAT ABOLISHES CA2+ BINDING CAPABILITY TO REVEAL THE DETAILS OF MOLECULAR MECHANISM AND THE PHYSIOLOGICAL SIGNIFICANCE OF THIS MECHANISM. IN AIM 2, WE WILL EVALUATE THICK FILAMENT BACKBONE STIFFNESS FROM BOTH ACTIVELY CONTRACTED AND PASSIVELY STRETCHED PORCINE MYOCARDIUM TO INVESTIGATE THE UNDERLYING MECHANISMS OF MYOFILAMENT LENGTH DEPENDENT ACTIVATION. IN AIM 3, WE WILL INTERROGATE THE STRUCTURAL, BIOCHEMICAL AND MECHANICAL CONSEQUENCES OF PORCINE MYOCARDIUM IN RESPONSE TO PKA TREATMENT. FINALLY, IN AIM 4, WE WILL EXTEND THE NEW FINDINGS REGARDING THICK FILAMENT REGULATORY PATHWAYS IN HEALTHY PORCINE MYOCARDIUM TO THE PATHOLOGICAL BASIS OF THICK FILAMENT DYSREGULATION IN HYPERTROPHIC, DILATED AND RESTRICTIVE CARDIOMYOPATHIES (HCM, DCM AND RCM RESPECTIVELY) MODEL PORCINE HEARTS. RESULTS ARE EXPECTED TO HAVE IMMEDIATE TRANSLATIONAL RELEVANCE BY IDENTIFYING POTENTIAL THERAPEUTIC TARGETS FOR SARCOMERE-BASED CARDIOMYOPATHIES.

FINLESS UCAS FLIGHT CONTROL WITH ACTIVE FLOW CONTROL EFFECTORS AND ADVANCED MANEUVER DEVELOPMENT

PROTOTYPE OF RECHARGEABLE NANOFLUID FLOW BATTERY FOR EV SYSTEMS

DEVELOPMENT OF MULTI-SCALE MODELING SOFTWARE FOR ENTANGLED SOFT MATTER IN ADVANCED SOLDIER PROTECTION

INTEGRATED HEALTH CARE FOR AFRICAN AMERICANS WITH MENTAL ILLNESS WHO ARE HOMELESS

SCH: INTEGRATING AI AND SYSTEM ENGINEERING FOR GLUCOSE REGULATION IN DIABETES - THE OBJECTIVE OF THIS PROPOSAL IS TO DEVELOP A PROTOTYPE FOR THE NEXT GENERATION MULTIVARIABLE AUTOMATED INSULIN DELIVERY (MVAID) SYSTEMS (ALSO CALLED ARTIFICIAL PANCREAS) BY INTEGRATING SYSTEMS ENGINEERING AND ARTIFICIAL INTELLIGENCE (AL) TECHNIQUES THAT WILL MITIGATE THE EFFECTS OF MEALS, PHYSICAL ACTIVITIES ,ACUTE PSYCHOLOGICAL STRESS INDUCEMENTS AND SLEEP IRREGULARITIES WITHOUT MANUAL INPUTS BY THE USER TO TIGHTLY REGULATE THE GLUCOSE LEVELS OF PEOPLE WITH DIABETES. THE FIRST GENERATION OF AUTOMATED INSULIN DELIVERY (AID) SYSTEMS RELIED ON HYBRID CLOSED-LOOP TECHNOLOGY, COLLECTING DATA FROM CONTINUOUS GLUCOSE MONITORING DEVICES AND REQUIRING MANUAL USER INPUTS FOR MITIGATING THE EFFECTS OF MEALS AND EXERCISE. THE MULTIVARIABLE AID THAT WE DEVELOPED PROVIDES A WELL-INTEGRATED NEXT-GENERATION SYSTEM THAT ANALYZES HISTORICAL AND REALTIME DATA FROM DIFFERENT SOURCES, INCLUDING CONTINUOUS GLUCOSE MONITORING SYSTEMS, INSULIN PUMPS, AND WEARABLE SENSORS IN WRISTBAND PHYSICAL ACTIVITY TRACKERS, TO MITIGATE THE EFFECTS OF MEALS, PHYSICAL ACTIVITIES, AND ACUTE PSYCHOLOGICAL STRESS WITHOUT MANUAL INPUTS BY THE USER. MEALS, PLANNED EXERCISES, MANY PHYSICAL ACTIVITIES OF DAILY LIVING, ACUTE PSYCHOLOGICAL STRESS, AND SLEEP IRREGULARITIES AFFECT BLOOD GLUCOSE LEVELS DIFFERENTIALLY, CHALLENGING PEOPLE WITH TYPE 1 DIABETES TO CONTINUOUSLY CONSIDER ALL THESE COMPLEX FACTORS IN MAINTAINING THEIR BLOOD GLUCOSE LEVELS IN THE TARGET RANGE. FURTHER IMPROVEMENT IN GLUCOSE REGULATION CAN BE ACHIEVED BY DEVELOPING NOVEL, INTERPRETABLE, AND INTERACTIVE AL TECHNIQUES THAT CAN EXPLAIN THEIR PREDICTIONS TO MEDICAL CARE PROVIDERS AND AID USERS, AND BY INTEGRATING THESE AL TECHNIQUES WITH SYSTEMS ENGINEERING TECHNIQUES TO DEVELOP AN AL-MVAID SYSTEM. THE FUNCTION OF THESE AL TECHNIQUES IS TO PREDICT THE STATE OF A PERSON BASED ON HISTORICAL TRENDS AND CURRENT DATA, AND PROVIDE ADDITIONAL VALUABLE INFORMATION TO THE MVAID SYSTEM TO RELIEVE THE USERS FROM ONEROUS REPETITIVE TASKS FOR INTERPRETING THEIR CURRENT METABOLIC STATE, PREDICTING THE IMPACT OF THEIR CURRENT ACTIONS ON FUTURE VARIATIONS IN GLUCOSE LEVELS, AND TUNING THE PARAMETERS OF THE AL-MVAID CONTROLLER. THE GOAL IS TO PRODUCE A POWERFUL USERFRIENDLY TECHNOLOGY THAT INTEGRATES NOVEL AL TECHNIQUES WITH MVAID SYSTEMS FOR MINIMAL USER BURDEN IN ACHIEVING TIGHT CONTROL OF GLUCOSE LEVELS DESPITE THE MANY COMPLEX GLYCEMIC DISTURBANCES OCCURRING IN FREELIVING CONDITIONS, SUCH AS MEALS, PHYSICAL ACTIVITIES, ACUTE PSYCHOLOGICAL STRESS, AND SLEEP IRREGULARITIES.

ANTIMICROBIAL PEPTIDES AND THEIR SYNTHETIC MIMICS - INVESTIGATING THE MECHANISM O

DEVELOPMENT AND CLINICAL VALIDATION OF DOMAIN-AWARE ANTHROPOMORPHIC MODEL OBSERVERS FOR TASK-BASED IMAGE QUALITY ASSESSMENT - IN THIS PROJECT WE AIM TO DEVELOP DEEP-LEARNING ANTHROPOMORPHIC MODEL OBSERVERS (AMO) AS A SUBSTITUTE FOR HUMAN OBSERVERS (HO) IN STUDIES AIMED TO ASSESS IMAGE QUALITY, DEFINED IN A TASK- BASED FASHION BASED ON CLINICAL DIAGNOSTIC PERFORMANCE. AN ACCURATE AMO WOULD ALLOW FAST AND CLINICALLY RELEVANT PROCEDURE FOR OPTIMIZATION OF IMAGING SYSTEM AND ALGORITHM DESIGNS. THE PROPOSED AMO METHODS AIM TO ACHIEVE GOOD GENERALIZATION, I.E., AN AMO DEVELOPED FOR IMAGES RECONSTRUCTED BY ONE ALGORITHM (OR SCANNER SETUP) SHOULD PREDICT HO PERFORMANCE ACCURATELY FOR A DIFFERENT RECONSTRUCTION ALGORITHM (OR DIFFERENT SCANNER SETTING). IN OTHER WORDS, A DESIRED AMO SHOULD BE TOLERANT TO DOMAIN SHIFTS. IT IS FURTHER PROPOSED TO DESIGN AMO WHICH IS AWARE OF ITS OWN LIMITATIONS AND TYPE OF IMAGES (OR ORGANS) IT CAN BE USED ON, SO THAT IT DOES NOT ATTEMPT TO EVALUATE IMAGES IT IS UNSUITED TO JUDGE. TO THIS END, WE PROPOSE TO AUGMENT THE AMO WITH THE CAPABILITY OF DOMAIN-AWARENESS TO RECOGNIZE IMAGE DOMAIN SHIFT, AND TO PROVIDE A MECHANISM THAT CAN BE USED TO ECONOMIZE THE USE OF HO STUDIES BY MORE EFFICIENTLY ADAPTING THE AMO TO NEWLY AVAILABLE DATASETS THIS PROJECT WILL ALSO AIM TO OVERCOME COMMON CONCERNS ABOUT DEEP LEARNING BEING A “BLACK- BOX” BY LEVERAGING METHODS FROM VISUAL PSYCHOPHYSICS, SUCH AS REVERSE-CORRELATION. THE ADVANTAGE OF THIS APPROACH IS THAT THE IDENTICAL PROCEDURE HAD BEEN APPLIED TO HO, THUS ALLOWING A DIRECT COMPARISON AND INTERPRETATION OF THE RESULTING RECEPTIVE FIELDS. TO ACCURATELY TRAIN, TEST AND CLINICALLY VALIDATE AMO WE WILL DEVELOP A RICH, IMAGE DATA SETS, ANNOTATED BY EXPERTS AND NON-EXPERTS, MIMICKING CT IMAGING OF THE LIVER. THEREFORE, A KEY COMPONENT OF THE PROJECT WILL BE DEVELOPMENT OF EXTENSIVE ANNOTATED DATASETS RANGING FROM NUMERICAL SIMULATION, ACQUISITION FROM 3D PRINTED PHANTOMS TO CLINICAL PATIENT DATA. FOR IMAGE ACQUISITION WE WILL USE SIMULATED, VIRTUAL CT AND CLINICAL (PHYSICAL) CT SCANNING FOLLOWED BY SEVERAL RECONSTRUCTION METHODS. WE CHOOSE TO USE LIVER CT IMAGING AS THE DEVELOPMENT PLATFORM FOR AMOS IN LOW-CONTRAST LESION LOCALIZATION AND DISCRIMINATION TASKS. THE CHOSEN APPLICATION IS SIGNIFICANT BY ITSELF BECAUSE, DESPITE YEARS OF RESEARCH, THERE IS STILL NO SYSTEMATIC FRAMEWORK FOR OPTIMIZATION OF THE MANY FACTORS IN IMAGING SYSTEM DESIGN FOR CLINICAL DIAGNOSTIC TASKS. WE BELIEVE THAT THE PROPOSED DOMAIN-AWARE AMO APPROACH AND AMO INTERPRETABILITY METHODOLOGY WILL HAVE A SUBSTANTIAL AND LASTING EFFECT NOT ONLY ON THE METHODOLOGY OF AMO DEVELOPMENT AND USE, BUT ALSO ON GENERAL DEEP-LEARNING APPLICATIONS IN MEDICAL IMAGING.

SCH: MULTIDIMENSIONAL MICROFLUIDIC SALIVARY SENSOR WITH ADVERSARIAL KNOWLEDGE DISTILLATION FOR POINT-OF-CARE ASSESSMENT OF PERIODONTITIS AND COMORBIDITIES - THE GOAL OF THIS RESEARCH IS TO DEVELOP A SENSOR DEVICE PROTOTYPE TO RAPIDLY MEASURE AN ARRAY OF DIVERSE SALIVARY BIOMARKERS AS INPUT FOR NOVEL MACHINE LEARNING (ML) METHODS THAT CAN PREDICT PERIODONTITIS AND MONITOR PERIODONTAL PROGRESSION. OUR LONG-TERM GOAL IS TO DEVELOP A RAPID, USER-FRIENDLY, AND LOW-COST POINTOF-CARE (POC) DEVICE, FOR USE IN EITHER A DENTIST’S OFFICE OR AT HOME, THAT RAPIDLY INTEGRATES AND ANALYZES DATA TO SUPPORT PATIENT MANAGEMENT. IT ADDRESSES THE PRIORITY AREA OF THE DATA SCIENCE, COMPUTATIONAL BIOLOGY, AND BIOINFORMATICS PROGRAM OF NIDCR IN INTEGRATING AND ANALYZING HIGH-VOLUME AND DIVERSE DATA TO BETTER UNDERSTAND DENTAL, ORAL, AND CRANIOFACIAL BIOLOGY AND DISEASES. ACCORDING TO THE CDC, NEARLY 50% ADULTS HAVE SOME FORM OF PERIODONTAL DISEASE. PERIOODONTITIS IS SILENTLY PROGRESSIVE AND PATIENTS OFTEN SEEK PROFESSIONAL CARE ONLY IN AN ADVANCED STAGE WHERE ADVANCED, PAINFUL AND COSTLY PROCEDURES ARE NEEDED TO CONTROL DISEASE OR REPLACE LOST TEETH. EARLY DETECTION OF PERIODONTAL DISEASE AT AN INDIVIDUAL PATIENT LEVEL IS REQUIRED AND THERE IS GROWING AWARENESS THAT MULTIPLE BIOMARKERS ARE VALUED IN PREDICTING RISK OF DISEASE IN INDIVIDUALS. WE HYPOTHESIZE THAT PREDICTIVE MODELS CAN BE ESTABLISHED BASED ON THE MEASUREMENTS OF A LARGE SET OF PERIODONTITIS-ASSOCIATED BIOMARKERS IN SALIVA; A SENSOR DEVICE THAT INTEGRATES MULTI-SENSOR MODALITIES AND THE MACHINE LEARNING (ML) MODELS WILL ADVANCE THE CLINICAL GOAL OF EARLY DIAGNOSIS OF PERIODONTITIS TO ENABLE EARLIER CLINICAL INTERVENTIONS. THUS, WE WILL DEVELOP AND APPLY THREE DISTINCTIVE SENSOR MODALITIES FOR DETECTING CONCENTRATIONS OF SALIVARY ANALYTES RELEVANT TO VARIOUS STAGES OF PERIODONTAL PROGRESSION, I.E., INFLAMMATION, SOFT TISSUE DESTRUCTION OR BONE DESTRUCTION (AIM 1). DATA FROM BOTH SENSOR OUTPUTS AND CLINICAL EXAMINATION WILL BE USED TO TRAIN ML MODELS VIA A NOVEL MULTI-MODAL ADVERSARIAL KNOWLEDGE DISTILLATION ML FRAMEWORK, WHICH PROMOTES ACCURATE EARLY PREDICTION WITH PARTIAL LONGITUDINAL DATA REPRESENTATIONS (AIM 2). THE MULTI-SENSOR MODALITIES AND THE ML MODELS WILL BE EMBEDDED IN A SINGLE MICROFLUIDIC DEVICE, INCORPORATING STEPS SUCH AS SAMPLING, DETECTION, AND DATA ANALYSIS AS AN INTEGRATED LAB-ON-A-CHIP, AND PERMITTING THE SENSOR DATA PREPROCESSED TO TRANSMIT ONLY THE ACTIONABLE INFORMATION TO THE OUTSIDE PLATFORM TO PROTECT THE USER'S PRIVACY (AIM 3). SUCH A DEVICE IS ANTICIPATED TO OFFER FOR UNOBTRUSIVE, ACCURATE, AND FREQUENT SALIVA-BASED SELF-MONITORING, AND PROVIDE DETAILED MEDICAL DATA TO SUPPORT CLINICAL DECISIONS. IT WILL BE AN EFFECTIVE TOOL FOR FUTURE PERSONALIZED MEDICINE AND DRAMATICALLY IMPROVE PATIENTS' ORAL HEALTH.

PROMOTING HEALTHY LIFESTYLE BEHAVIORS TO ADDRESS OBESITY RELATED COMPLICATIONS OF AFRICAN AMERICANS WITH SEVERE MENTAL ILLNESS USING PEER NAVIGATORS

INERTIAL NEURAL SURROGATES FOR STABLE DYNAMICAL PREDICTION

CRI: II-NEW: MYSTIC: PROGRAMMABLE SYSTEMS RESEARCH TESTBED TO EXPLORE A STACK-WIDE ADAPTIVE SYSTEM FABRIC

PARTICIPATION IN INTENSITY FRONTIER NEUTRINO PHYSICS

MULTIVARIABLE ARTIFICIAL PANCREAS SYSTEM TO DETECT AND MITIGATE THE EFFECTS OF UNANNOUNCED PHYSICAL ACTIVITIES AND ACUTE PSYCHOLOGICAL STRESS - IIT PROJECT SUMMARY/ABSTRACT THE OBJECTIVE OF THIS PROPOSAL IS TO DEMONSTRATE A VIABLE, FUNCTIONALLY INTEGRATED MULTIVARIABLE ARTIFICIAL PANCREAS THAT WILL MITIGATE MEAL, PHYSICAL ACTIVITY AND ACUTE PSYCHOLOGICAL STRESS CHALLENGES WITHOUT ANY MANUAL INPUTS TO BETTER REGULATE GLUCOSE LEVELS OF PEOPLE WITH DIABETES. THE FIRST GENERATION OF ARTIFICIAL PANCREAS (AP) SYSTEMS, THE HYBRID CLOSED-LOOP AP, COLLECTS DATA FROM CONTINUOUS GLUCOSE MONITORING DEVICES AND RELIES ON MANUAL USER INPUTS FOR MITIGATING THE EFFECTS OF MEALS AND PHYSICAL ACTIVITIES. ACUTE PSYCHOLOGICAL STRESS AND MANY OTHER PHYSICAL ACTIVITIES BESIDES PLANNED EXERCISE CAN AFFECT BLOOD GLUCOSE LEVELS AND CAUSE CHALLENGES TO MAINTAINING EUGLYCEMIA FOR PEOPLE WITH TYPE 1 DIABETES. VARIOUS PHYSICAL ACTIVITIES AND ACUTE PSYCHOLOGICAL STRESS EVENTS AFFECT THE METABOLISM AND SENSITIVITY TO INSULIN IN DIFFERENT WAYS. HENCE, THEIR TYPES, INTENSITIES AND DURATIONS, AND THEIR INDIVIDUAL AND CONCURRENT PRESENCE MUST BE DETECTED IN ORDER TO DETERMINE THE OPTIMAL INSULIN ADMINISTRATION. THE MULTIVARIABLE ARTIFICIAL PANCREAS APPROACH PROVIDES A WELL-INTEGRATED AND USER-FRIENDLY TECHNOLOGY WITH MINIMAL BURDEN ON THE USER AND MITIGATES THE EFFECTS OF UNEXPECTED PHYSICAL ACTIVITIES AND ACUTE PSYCHOLOGICAL STRESS INDUCEMENTS. ADDITIONALLY, THIS TECHNOLOGY WOULD BE SAFER BY REDUCING THE NUMBER AND DURATION OF HYPOGLYCEMIC AND HYPERGLYCEMIC EVENTS, COMPARED TO APS BASED EXCLUSIVELY ON CONTINUOUS GLUCOSE MONITORING DEVICE DATA. SUCH MULTIVARIABLE AP SYSTEMS CAN ONLY BE DEVELOPED BY USING A SOPHISTICATED MULTIVARIABLE APPROACH THAT USES REAL-TIME INFORMATION FROM CONTINUOUS GLUCOSE MONITORING DEVICES AND PHYSIOLOGICAL VARIABLES OBTAINED FROM WEARABLE DEVICES WORN IN FREE-LIVING DAILY LIFE.

"UNDERSTANDING THE FLOW PHYSICS OF ENERGY EXTRACTION FROM GUSTING FLOWS TO ENHANCE MICRO AIR VEHICLE PERFORMANCE"

CONTEXTUAL RESEARCH-EMPIRICAL RESEARCH--DETECTING, TRACKING, AND MODELING COGNITIVE, AFFECTIVE, AND METACOGNITIVE REGULATORY PROCESSES TO OPTIMIZE LE

**AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** THE COMMUNITY FOOD MOBILIZATION IN CHICAGO (CF-MOB) PROJECT INVESTIGATES MECHANISMS TOTRANSFORM THE STRUCTURES OF FOOD PRODUCTION AND DISTRIBUTION IN WAYS THAT CENTER RACIAL JUSTICE,SOVEREIGNTY AND COMMUNITY FOOD ACCESS. IT AIMS TO ADVANCE UNDERSTANDING OF PUBLIC PROCUREMENT&#39;S ROLE IN INVESTING IN LOCAL, EQUITABLE FOOD SUPPLY CHAIN DEVELOPMENT, WHILE EMPOWERING AND CREATING SPACE FOR BLACK, INDIGENOUS AND PEOPLE OF COLOR (BIPOC) FOOD STAKEHOLDERS TO SELF-DETERMINE THEIR PARTICIPATION IN IT. CF-MOB LEVERAGES STRONG MULTI-SECTORAL PARTNERSHIPS AMONG FOOD PRODUCERS, WORKERS, EATERS, ADVOCATES AND PUBLIC INSTITUTIONS AROUND THE METRO CHICAGO GOOD FOOD PURCHASING INITIATIVE (GFPI). GFPI AIMS TO REORIENT PUBLIC INSTITUTIONS&#39; LARGE SPENDING ON FOOD TOWARDS PRODUCTS ALIGNED WITH FIVE GOOD FOOD VALUES AND ANCHORS RESOURCES FOR BIPOC STAKEHOLDERS TO BENEFIT FROM IT. THIS MASSIVE CHALLENGE REQUIRES TARGETED RESEARCH TO IDENTIFY MECHANISMS FOR OVERCOMING RESOURCE APARTHEID AND ARTICULATING STRATEGIC ROLES FOR PUBLIC PROCUREMENT IN THIS PROCESS. THE TEAM WILL RESEARCH STRUCTURAL BARRIERS AND PRACTITIONER EXPERIENCES ALONG THE FOOD SUPPLY CHAIN, INCLUDING THE COMMUNITY&#39;S DIVERSE VISIONS TO DESIGN A SET OF INNOVATIVE, FOOD MOBILIZATION PATHWAYS. THEY WILL IDENTIFY A SHORTLIST OF HIGH-IMPACT, SUSTAINABLE FOOD PRODUCTS AVAILABLE IN THE 300-MILE RADIUS CHICAGO FOODSHED, IDENTIFY AND MAP SUPPLY CHAIN GAPS FOR GFPI-ALIGNED PRODUCTS, AND MODEL BUDGETARY SCENARIOS AND PROCUREMENT PROCESS REFORMS ENABLING INTEGRATION OF LOCAL FOOD SUPPLIERS, ESPECIALLY BIPOC, INTO INSTITUTIONAL PROCUREMENT PROCESSES. THEY WILL DEVELOP A DIGITAL PLATFORM--METRO CHICAGO GOOD FOOD DASHBOARD--TO SHARE INFORMATION ABOUT FOOD PROCUREMENT AND MOBILIZATION OPPORTUNITIES, AND CONNECT THE DIVERSE CONSTITUENCIES ACROSS CHICAGOLAND.

WOUND FIELD AND HYBRID SYNCHRONOUS MACHINES FOR ELECTRIC VEHICLE (EV) TRACTION WITH BRUSHLESS CAPACITIVE ROTOR FIELD EXCITATION

NEW AWARD TO: ILLINOIS INSTITUTE OF TECHNOLOGY AWARD NUMBER: DE-FE0031931 PROJECT TITLED: FACILITATING IMPLEMENTATION OF HIGH-VOLUME FLY ASH USE IN PRECAST CONCRETE CONSTRUCTION TO INCREASE BENEFICIAL UTILIZATION

REHABILITATION LONG-TERM TRAINING - REHABILITATION COUNSELING

"PREPARATION FOR THE IMPPLANTATION OF AN INTRACORICAL VISUAL PROSTHESIS IN A HUMAN".

TAS::97 0400::TAS "(DARPA) ALGEBRAIC STATISTICS FOR NETWORK MODELS"

A MULTI-SCALE MODELING AND EXPERIMENTAL PROGRAM FOR THE DYNAMIC MECHANICAL RESPONSE OF TISSUE

LEAD-BASED PAINT HAZARD CONTROL IN PRIVATELY-OWNED HOUSING

LONG-TERM TRAINING FOR REHABILITATION OF INDIVIDUALS WHO ARE MENTALLY ILL

NRI: RECEDING HORIZON INTEGRITY-A NEW NAVIGATION SAFETY METHODOLOGY FOR CO-ROBOTIC PASSENGER VEHICLES

ADAPTIVE ANALYTIC MULTISCALE MODELING USING PSEUDOSPECTRAL WAVEPACKETS

PARTICIPATION IN HIGH ENERGY PHYSICS

CAREER: THE MOLECULAR STRUCTURE OF TYPE II COLLAGEN BY FIBER CRYSTALLOGRAPHY

GRADUATE TRAINING FOR FRONTIER RESEARCH USING SYNCHROTRON RADIATION

REHABILITATION LONG-TERM TRAINING GRANT PROGRAM: MS IN REHABILITATION COUNSELING

MR QUANTIFICATION OF MYOCARDIAL OXYGEN UTILIZATION IN CHRONIC MYOCARDIAL INFARCTION WITHOUT CONTRAST

THE ROLE OF LAGRANGIAN COHERENT STRUCTURES IN COUPLING THE IONOSPHERE-ATMOSPHERE DURING WEAK AND STRONG POLAR VORTICES

PASSIVE CONTROL OF NON-CANONICAL FLOWS WITH ANISOTROPIC POROUS MATERIALS.