Board Of Regents Of The University Of Nebraska

NEBRASKA RESEARCH NETWORK IN FUNCTIONAL GENOMICS

U.S. CMS OPERATIONS AT THE LARGE HADRON COLLIDER

CARES ACT INSTITUTIONAL ASSISTANCE

GREAT PLAINS IDEA-CTR

UNMC EPPLEY CANCER CENTER SUPPORT GRANT

CHILDREN'S ONCOLOGY GROUP STATISTICS AND DATA CENTER GRANT

CARES ACT STUDENT ASSISTANCE

UNO REQUEST UNDER CARES ACT (HIGHER EDUCATION EMERGENCY RELIEF FUND) INSTITUTION

STAPHYLOCOCCAL BIOFILM AND DISEASE

UNO REQUEST UNDER CARES ACT (HIGHER EDUCATION EMERGENCY RELIEF FUND)

NATIONAL COUNTERTERRORISM, INNOVATION, TECHNOLOGY, AND EDUCATION (NCITE) CENTER

CENTRAL STATES CENTER FOR AGRICULTURAL SAFETY AND HEALTH (CS-CASH)

THE MIDWEST CENTRAL PLAINS REGIONAL FOOD BUSINESS CENTER (MCP RFBC) WILL MOBILIZE EXISTING RESOURCES ACROSS ARKANSAS, IOWA, KANSAS, MISSOURI, NEBRASKA, OKLAHOMA, AND A DESIGNATED TRIBAL CORRIDOR TO AMPLIFY AND ACCELERATE THE DELIVERY OF SERVICES TO PRODUC

THE COMMUNITY WILDFIRE DEFENSE GRANT PROGRAM AIMS TO ASSIST AT RISK LOCAL COMMUNITIES AND INDIAN TRIBES IN PLANNING FOR AND MITIGATING AGAINST THE RISK CREATED BY WILDFIRE. THE PROGRAM HELPS COMMUNITIES IMPLEMENT THE NATIONAL COHESIVE WILDLAND FIRE MANAGEMENT STRATEGY. IT PRIORITIZES COMMUNITIES THAT ARE IN AREAS WITH HIGH OR VERY HIGH WILDFIRE HAZARD POTENTIAL, ARE LOW INCOME, OR HAVE BEEN IMPACTED BY A SEVERE DISASTER THAT INCREASES THE RISK OF WILDFIRE. THE PROGRAM IS A RESPONSE TO REDUCE WILDFIRE RISK AND ENHANCE FIRE MANAGEMENT STRATEGIES ACROSS THE UNITED STATES. THE FOLLOWING PROJECTS HAVE BEEN SELECTED FOR FUNDING IN NEBRASKA. BROWN COUNTY MITIGATION CREW, STOP THE BURN: CREATING RESILIENT WORKING LANDS FOR BROWN COUNTY, STOP THE BURN: CREATING RESILIENT WORKING LANDS FOR ROCK COUNTY.

NEBRASKA CENTER FOR THE PREVENTION OF OBESITY DISEASES THROUGH DIETARY MOLECULES

SCRIPPS NEUROAIDS PRECLINICAL STUDIES (SNAPS)

NEBRASKA 2010-15 RII PROJECT: NANOHYBRID MATERIALS & ALGAL BIOLOGY

NEBRASKA CENTER FOR INTEGRATED BIOMOLECULAR COMMUNICATION (CIBC)

HARNESSING MOVEMENT VARIABILITY TO TREAT AND PREVENT MOTOR RELATED DISORDER

RII TRACK-1: EMERGENT QUANTUM MATERIALS AND TECHNOLOGIES (EQUATE)

RII TRACK-1: CENTER FOR ROOT AND RHIZOBIOME INNOVATION (CRRI)

NEURO-CIRCULATORY FUNCTION IN CHRONIC HEART DISEASE

NEBRASKA CENTER FOR MOLECULAR TARGET DISCOVERY AND DEVELOPMENT

NATIONAL INFECTION CONTROL STRENGTHENING FOR SMALL AND RURAL HOSPITALS - SUPPLEMENT

RURAL DRUG ADDICTION RESEARCH CENTER

SPORE IN GASTROINTESTINAL CANCER

NANOART MANUFACTURE DELIVERY AND PHARMACOKINETICS FOR OPTIMIZING DRUG ADHERENCE

QUALITY IMPROVEMENT CENTER FOR WORKFORCE DEVELOPMENT

COGNITIVE NEUROSCIENCE OF DEVELOPMENT AND AGING (CONDA) CENTER

UNIVERSITY TRANSPORTATION CENTERS

NEBRASKA RESEARCH NETWORK IN FUNCTIONAL GENOMICS

REQUEST OAA PROVIDE: (1) FY 2007 FUNDING TO NEBRASKA UNIVERSITY AWARD EPP-A-00-06-00016-00 IN THE AMOUNT OF $1,830,000; AND (2) CHANGE IN THE NMS THE

SYSTEMS ANALYSIS OF THE PHYSIOLOGICAL AND MOLECULAR MECHANISMS OF SORGHUM NITROGEN USE EFFICIENCY, WATER USE EFFICIENCY AND INTERACTIONS WITH THE...

NEBRASKA CENTER FOR NANOMEDICINE

PANCREATIC CANCER DETECTION CONSORTIUM

UNIVERSITY OF NEBRASKA AT KEARNEY CARES HIGHER EDUCATION EMERGENCY RELIEF FUND-INSTITUTIONAL PORTION

B5: BIGGER BETTER BRASSICACEAE BIOFUELS AND BIOPRODUCTS

INFLATION REDUCTION ACT STRENGTHENING NEBRASKAS URBAN FOREST INFRASTRUCTURE

EDUCATION RESEARCH AND DEVELOPMENT CENTERS

NEBRASKA EMPLOYABILITY PROJECT (NEP)

SHIGA-TOXIGENIC ESCHERICHIA COLI (STEC)IN THE BEEF CHAIN: ASSESSING AND MITIGATING THE RISK BY TRANSLATIONAL SCIENCE, EDUCATION AND OUTREACH

MRSEC: POLARIZATION AND SPIN PHENOMENA IN NANOFERROIC STRUCTURES (P-SPINS)

CARES ACT: HIGHER EDUCATION EMERGENCY RELIEF FUND FOR UNK

U.S. CMS PHASE-1 UPGRADES

NEUROPROTECTIVE IMMUNITY AND HIV DEMENTIA

NNTC DATA COORDINATING CENTER

NEBRASKA MATH

UNIVERSITY TRANSPORTATION CENTERS

CHILD WELFARE TECHNICAL ASSISTANCE IMPLEMENTATION CENTERS

PREDICTIONS OF DRIVER SAFETY IN ADVANCING AGE

NEBRASKA CENTER FOR NANOMEDICINE

MATERIALS RESEARCH SCIENCE AND ENGINEERING CENTER: QUANTUM AND SPIN PHENOMENA IN NANOMAGNETIC STRUCTURES

COLLABORATIVE RESEARCH: ANDRILL - - INVESTIGATING ANTARCTICA'S ROLE IN CENOZOIC GLOBAL ENVIRONMENTAL CHANGE

UNCOVERING HIV/OPIOID EFFECTS IN THE BRAIN AT THE SINGLE CELL LEVEL: TRANSCRIPTION, CHROMATIN ACCESSIBILITY, AND RESERVOIR ANALYSIS IN THE SIV/CART/MORPHINE/RHESUS MONKEY MODEL - PROJECT SUMMARY A COMPREHENSIVE INTERDISCIPLINARY APPROACH PROPOSED TO SUPPORT THE SINGLE CELL OPIOID RESPONSES IN THE CONTEXT OF HIV (SCORCH) PROGRAM EXPANSION: CNS DATA GENERATION FOR CHRONIC OPIOID, METHAMPHETAMINE, AND/OR COCAINE EXPOSURES RFA FROM THE NATIONAL INSTITUTE ON DRUG ABUSE (NIDA). WE WILL PERFORM STUDIES ON THE INTERPLAY OF HIV PATHOGENESIS AND OPIOID ABUSE IN THE GOLD-STANDARD SIV/NONHUMAN PRIMATE SYSTEM, USING SINGLE-CELL RNA SEQUENCING (SCRNASEQ) TO ASSESS INDIVIDUAL CELLULAR TRANSCRIPTOMES. THIS WILL GIVE US OBTAIN UNPARALLELED INSIGHT INTO THE VIRAL AND DRUG-INDUCED EFFECTS ON DIVERSE CELL TYPES IN BRAIN IN REGIONS CRITICAL FOR HIV INFECTION AND OPIOID ABUSE. IN ADDITION, WE WILL ALSO FOCUS ON PRIMARY TARGETS OF HIV AND DRIVERS OF NEUROPATHOGENESIS, MICROGLIA AND BRAIN MACROPHAGES, USING SCRNASEQ AS WELL AS SINGLE-CELL ASSAY FOR TRANSPOSASE-ACCESSIBLE CHROMATIN SEQUENCING (SCATACSEQ) TO GAIN INSIGHT INTO THE EPIGENETIC REGULATION OF GENE EXPRESSION AT THE SINGLE CELL LEVEL. THESE WILL BE COMBINED WITH STATE-OF-THE-ART SENSITIVE ASSAYS FOR VIRUS IN THE BRAIN. WE WILL ENSURE OUR DATA ADHERE TO THE FAIR (FINDABLE, ACCESSIBLE, INTEROPERABLE, AND REUSABLE) STANDARDS, AND WILL WORK CLOSELY WITH OTHER MEMBERS OF THE SCORCH PROGRAM TO SHARE AND DISSEMINATE DATA TO YIELD MAXIMAL ADVANCEMENT TO THE FIELD. OUR EXPERIMENTS ARE CAREFULLY DESIGNED TO ADDRESS THE ROLE OF VIRUS, DRUGS, AND THEIR INTERACTIONS, AS WELL AS INCLUDE THE CLINICALLY RELEVANT SCENARIOS OF THOSE TAKING ANTIRETROVIRALS TO SUPPRESS VIRUS, AND THOSE WHO DO NOT. OUR RIGOR AND REPRODUCIBILITY ARE FACILITATED BY OUR DETAILED POWER ANALYSIS WITH PROPER SAMPLE SIZES, AS WELL AS OUR EXPERIMENTAL DESIGN TO MATCH THE STANDARDS OF BLOCKING, REPLICATION AND RANDOMIZATION. THE RESULTS FROM THESE STUDIES WILL PROVIDE NOVEL INSIGHTS INTO THE CNS EFFECTS OF HIV AND DRUG ABUSE.

NEBRASKA CENTER FOR CELLULAR SIGNALING

PANCREATIC CANCER METASTASIS

ALTERED LIPID DROPLET TRAFFICKING: ROLE IN ALCOHOLIC FATTY LIVER DISEASE

PAR04-122 EXTRAMURAL RESEARCH FACILITIES CONSTRUCTION A*

EXTRAMURAL RESEARCH FACILITIES CONSTRUCTION

THE MOLECULAR BIOLOGY OF NEUROSENSORY SYSTEMS

REDOX BIOLOGY CENTER

PROBING NUCLEAR AND ELECTRONIC DYNAMICS IN ULTRAFAST RING-CONVERSION MOLECULAR REACTIONS

RYAN WHITE PART C OUTPATIENT EIS PROGRAM

NATIONAL EMERGING SPECIAL PATHOGENS TRAINING AND EDUCATION CENTER (NETEC)

GENERATE RESEARCH-BASED EVIDENCE TO SUPPORT THE GROWTH OF VIBRANT IRRIGATION AND MECHANIZATION MARKETS, DEVELOP STRONG INSTITUTIONS AND LOCAL CAPACITY FOR THEIR SUSTAINABILITY, AND FOSTER OPPORTUNITIES FOR EQUITABLE ACCESS, ESPECIALLY AMONG POOR AND WOMEN SMALLHOLDER FARMERS.

UNIVERSITY TRANSPORTATION CENTER - IMPROVING SAFETY AND MINIMIZING RISK WITH MULTIMODAL FREIGHT MOVEMENT.

NEBRASKA CENTER FOR HEART AND VASCULAR RESEARCH - PROJECT TITLE: NEBRASKA CENTER FOR HEART AND VASCULAR RESEARCH PROJECT SUMMARY: OVERALL CENTER ORGANIZATION AND MANAGEMENT PLAN HEART AND VASCULAR DISEASES (HVD) ARE THE LEADING CAUSE OF DEATH AND HOSPITALIZATION IN THE UNITED STATES, NEBRASKA INCLUDED. THE GOAL OF THE NEBRASKA CENTER FOR HEART AND VASCULAR RESEARCH (CHVR) IS TO BUILD THE PHYSICAL AND INTELLECTUAL RESOURCES AT THE UNIVERSITY OF NEBRASKA MEDICAL CENTER (UNMC) TO PROPEL THE ABILITY OF OUR FACULTY TO CONDUCT RESEARCH THAT DRIVES THE HEART AND VASCULAR DISEASE (HVD) FIELD FORWARD. OUR CENTER HAS EXCEPTIONAL INSTITUTIONAL SUPPORT, IS WELL-ALIGNED WITH UNMC’S AREAS OF RESEARCH EMPHASIS, AND WE HAVE AN OUTSTANDING BASELINE CADRE OF INVESTIGATORS WITH EXPERTISE IN HVD DISEASE. THE MAIN OBJECTIVE OF THIS PHASE I COBRE IS TO DEVELOP A CENTER THAT PROMOTES AND SUPPORTS EXCELLENCE IN HVD RESEARCH THROUGH THE DEVELOPMENT OF EARLY CAREER RESEARCHERS, PROMOTES COLLABORATIVE RESEARCH THAT IS CRITICAL TO SOLVING COMPLEX RESEARCH PROBLEMS, AND EXPANDS SUPPORT FOR ALL HVD RESEARCH WITH CUTTING EDGE INFRASTRUCTURE AND MENTORING ACTIVITIES. WE HAVE SELECTED RESEARCH PROJECT LEADERS WITH RESEARCH PROJECTS THAT HAVE A STRONG CONNECTION TO THE FOCUS OF THE COBRE AND ARE POISED TO BECOME INDEPENDENT RESEARCHERS. THE COBRE WILL MAXIMIZE THE ABILITY OF THE CENTER TO BOOST HVD RESEARCH AT UNMC, ENHANCE FACULTY RESEARCH TRAJECTORIES, MENTOR EARLY CAREER INVESTIGATORS TO PRODUCTIVE RESEARCH CAREERS, AND REDUCE BARRIERS TO RESEARCH TO DRIVE DISCOVERY. THE CENTER HAS BROUGHT TOGETHER THE FULL RANGE OF CUTTING-EDGE EXPERTISE NEEDED TO ACCOMPLISH OUR MISSION AND ASSEMBLED A STRONG MENTORING PROGRAM THAT WILL TRAIN MENTORS IN BEST PRACTICES. TO CATALYZE CUTTING EDGE HVD RESEARCH THE CENTER WILL SUPPORT EXISTING RESOURCES AND GROW NEW ONES LIKE THE PROPOSED BIOASSAY CORE FOCUSED ON THE TARGETED EXAMINATION OF PROTEINS. WITH THESE GOALS AND THE PHASE I COBRE FUNDING, THE CENTER WILL SUPPORT THE INFRASTRUCTURE REQUIRED FOR CUTTING-EDGE HVD RESEARCH, INCREASE THE NUMBER OF FUNDED RESEARCHERS, AND TOTAL HVD FUNDING TO PROMOTE A REPUTATION AND CULTURE OF EXCELLENCE IN HVD RESEARCH THAT CAN IMPROVE PATIENT OUTCOMES AND REDUCE HVD HEALTH DISPARITIES.

DNA-ENABLED HIERARCHICAL ASSEMBLY OF GRAPHENE ELECTRONICS

KAPOSI'S SARCOMA AND HUMAN HERPESVIRUS IN AFRICA

OVERCOMING STROMAL BARRIERS TO THERAPEUTICS IN PANCREAS CANCER

BHECN MENTAL HEALTH TECHNOLOGY TRANSFER CENTER

CHILD CARE AND YOUTH TRAINING AND TECHNICAL ASSISTANCE PROJECT

MRI UNIV AFFILIATED INTERDISCIPLINARY TRAINING PROGRAM

A HIGH-THROUGHPUT COMPUTATIONAL AND EXPERIMENTAL APPROACH TO THE DESIGN OF UNCONVENTIONAL MAGNETS

CONSTRUCTION OF A NANOSCIENCE METROLOGY FACILITY AT THE UNIVERSITY OF NEBRASKA-LINCOLN.

UNIVERSITY TRANSPORTATION CENTER

SYNTHETIC NANOVACCINES AGAINST RESPIRATORY PATHOGENS (SYNARP)

THIS EDA INVESTMENT SUPPORTS THE HEARTLAND ROBOTICS CLUSTER, LED BY THE INVEST NEBRASKA CORPORATION, WITH STRENGTHENING AGRICULTURAL TECHNOLOGY IN NEBRASKA BY ACCELERATING NEBRASKA'S LEADERSHIP IN THE AGRICULTURAL INDUSTRY THROUGH ROBOTIC TECHNOLOGIES AND ADVANCED MANUFACTURING AUTOMATION WHILE ALSO REVITALIZING THE REGION'S RURAL LABOR FORCE AND STRENGTHENING THE NATION'S FOOD SUPPLY CHAIN. THE PROJECTS FUNDED AS PART OF THIS AWARD INCLUDE EXPANSION OF THE NEBRASKA INNOVATION STUDIO IN ROBOTICS-SPECIFIC PROGRAMMING AND PROTOTYPING EQUIPMENT, CREATING AN ENVIRONMENT FOR INNOVATORS FROM ACROSS THE STATE AND FROM A VARIETY OF DEMOGRAPHICS TO DEVELOP AUTOMATION AND ROBOTIC SOLUTIONS. THE COALITION ALSO WILL IMPLEMENT SEVEN OTHER PROJECTS, INCLUDING ROBOTICS CURRICULUM DEVELOPMENT; WORKFORCE OUTREACH TO PROVIDE RURAL AREAS WITH OPPORTUNITIES TO WORK WITH CUTTING EDGE TECHNOLOGY; TECHNOLOGY COMMERCIALIZATION EFFORTS IN PARTNERSHIP WITH PRIVATE INDUSTRY; AND MANUFACTURING DEMONSTRATION SPACES TO DE-RISK ADOPTION OF NEW TECHNOLOGIES. ONCE IMPLEMENTED, THE INVESTMENT WILL HELP DEVELOP AND STRENGTHEN REGIONAL INDUSTRY CLUSTERS - ALL WHILE EMBRACING ECONOMIC EQUITY, CREATING GOOD-PAYING JOBS, AND ENHANCING U.S. COMPETITIVENESS GLOBALLY.

CENTER FOR CARDIOVASCULAR RESEARCH IN BIOMECHANICS - PROJECT SUMMARY – OVERALL WE PROPOSE TO ESTABLISH THE CENTER FOR CARDIOVASCULAR RESEARCH IN BIOMECHANICS (CRIB), WHICH WILL PROVIDE A FOUNDATION FOR SYNERGISTIC TRANSLATIONAL RESEARCH ACTIVITIES AIMED AT DEVELOPING NOVEL MATERIALS AND DEVICES TO TREAT CARDIOVASCULAR DISEASES. TO MAXIMIZE IMPACT, THE INITIAL SET OF PROJECTS WILL FOCUS ON PERIPHERAL ARTERIAL DISEASE (PAD) OF THE LOWER EXTREMITY ARTERIES BECAUSE PAD TREATMENTS CONTINUE TO DISAPPOINT DESPITE DECADES OF IMPROVEMENTS AND REFINEMENTS IN TECHNOLOGIES AND PHARMACOLOGICAL ADJUNCTS. THE HIGH RATE OF TREATMENT FAILURES MAKES PAD ONE OF THE MOST EXPENSIVE VASCULAR DISEASES TO TREAT ON A PER-PATIENT BASIS, INCREASING THE URGENCY OF DEVELOPING BETTER BIOMEDICAL MATERIALS AND DEVICES. OUR TEAM HAS DONE EXTENSIVE RESEARCH IN PAD, AND THE STRENGTH OF OUR APPROACH IS IN THE USE OF HUMAN TISSUES, LARGE PRECLINICAL ANIMAL MODELS, AND DIVERSE MULTIDISCIPLINARY COLLABORATIONS THAT ENABLE THE DIRECT CLINICAL TRANSLATION OF OUR DISCOVERIES. SUPPORT OF THE COBRE WILL HELP US BUILD A UNIQUE RESEARCH ENVIRONMENT WITH INFRASTRUCTURE TO ATTRACT AND TRAIN SCIENTISTS IN TRANSLATIONAL CARDIOVASCULAR BIOMECHANICS RESEARCH. OUR CRIB CENTER WILL BE DIRECTED BY A SENIOR NIH R01- FUNDED INVESTIGATOR DR. ALEXEY KAMENSKIY WHO HAS BUILT ONE OF THE LARGEST DATABASES OF INTERLINKED MECHANICAL, STRUCTURAL, AND DEMOGRAPHIC CHARACTERISTICS OF HUMAN ARTERIES AND USED IT TO DEVELOP NOVEL SOLUTIONS TO IMPROVE CLINICAL OUTCOMES OF VASCULAR DISEASE TREATMENTS. THE CRIB CENTER WILL ALSO INCLUDE A UNIQUE TISSUE ANALYSIS CORE (TAC) DEDICATED TO PERFORMING MECHANICAL, STRUCTURAL, AND BIOLOGICAL EVALUATIONS OF HUMAN, LARGE ANIMAL, AND MAN-MADE MATERIALS, AND DIRECTED BY AN NIH R01-FUNDED SCIENTIST DR. ANASTASIA DESYATOVA. THE TAC WILL SUPPORT THREE PROJECTS BY RESEARCH PROJECT LEADERS (RPLS) FOCUSED ON THE EFFECTS OF SEX ON VASCULAR ELASTOGENESIS (RPL MAJID JADIDI) AND THE DEVELOPMENT OF DEVICES FOR PAD SURGICAL TREATMENT AND POST-TREATMENT RECOVERY USING NOVEL ELASTOMERIC BYPASS GRAFTS (RPL KASPARS MALECKIS) AND ISCHEMIC WOUND DRESSINGS (RPL YURY SALKOVSKIY). ALL THREE PROJECTS ARE BASED ON SOLID PRELIMINARY DATA FROM HUMANS AND LARGE ANIMALS AND ARE LED BY TENURE-TRACK ASSISTANT PROFESSORS. EACH RPL IS MENTORED BY TWO SEASONED INVESTIGATORS: AN NIH R01- FUNDED CLINICIAN-SCIENTIST TO ENSURE TRANSLATION, AND A WORLD-FAMOUS BASIC SCIENTIST FROM THE RPL’S FIELD OF EXPERTISE TO ADVISE ON RESEARCH STRATEGY. THE FOCUS OF OUR CENTER ON RESEARCH SUPPORTING THE DEVELOPMENT OF DEVICES AND MATERIALS FOR VASCULAR DISEASE TREATMENT IS DIFFERENT FROM MORE TRADITIONAL CELLULAR AND MOLECULAR- BASED APPROACHES AND STRATEGICALLY UTILIZES OUR STRENGTHS IN HUMAN ARTERY BIOMECHANICS. WITH THE HELP OF THE COBRE, CRIB WILL CREATE A NOVEL BIOMEDICAL RESEARCH INFRASTRUCTURE WITH A DIRECT TRANSLATIONAL FOCUS THAT WILL STRENGTHEN THE TECHNOLOGICAL AND INTELLECTUAL POTENTIAL OF OUR UNIVERSITY, ATTRACT AND RETAIN TALENT, INCREASE INTERACTIONS WITH THE BIOMEDICAL DEVICE INDUSTRY, SUPPORT MANY EXISTING IDEA PROGRAMS, AND PROVIDE SIGNIFICANT BENEFITS FOR THE HEALTH OF NEBRASKANS AND SOCIETY AT LARGE.

RII TRACK-2 FEC: FROM ECOSYSTEMS TO EVOLUTION: HARNESSING ELEMENTAL DATA TO DETECT STOICHIOMETRIC CONTROL-POINTS AND THEIR CONSEQUENCES FOR ORGANISMAL EVOLUTION

ALCOHOL CENTER OF RESEARCH -- NEBRASKA (ACORN) - THE GOAL OF THE ALCOHOL CENTER OF RESEARCH-NEBRASKA (ACORN) IS TO EXPAND EXISTING STRENGTHS AND EXPERTISE IN NEBRASKA TO DEVELOP A NOVEL NICHE IN ALCOHOL RESEARCH, BY CREATING A CENTER FOCUSED ON THE ALCOHOL EXPOSOME. ALCOHOL RESEARCH HAS BEEN A MAJOR AREA OF EMPHASIS IN NEBRASKA (AT THE OMAHA VA MEDICAL CENTER RESEARCH SERVICE AND AT THE UNIVERSITY OF NEBRASKA MEDICAL CENTER) FOR OVER 5 DECADES. AS A RESULT, MANY CONTRIBUTIONS TO THE FIELD OF ALCOHOL RESEARCH AND THE TREATMENT OF ALCOHOLIC LIVER DISEASE HAVE BEEN MADE. STUDIES EXAMINING THE EFFECTS OF ALCOHOL ON TRACE METAL METABOLISM, LUNG BIOLOGY AND PHYSIOLOGY, MECHANISMS OF ALCOHOLIC FATTY LIVER, ROLE OF ALDEHYDE ADDUCTS IN ALCOHOLIC CELL INJURY, HEPATIC PROTEIN TRAFFICKING AND SIGNAL TRANSDUCTION EVENTS AND THE ROLE OF IMMUNE MECHANISMS IN ALCOHOLIC LIVER DISEASE HAVE BEEN SOME OF THE KEY AREAS OF INVESTIGATION. OUR GOAL IS TO TRANSLATE TO HUMANS HOW FACTORS IN THE EXPOSOME SUCH AS AGE, NUTRITIONAL STATUS, CIGARETTE SMOKING, AND EXPOSURE TO PATHOGENS INTERACT IN THE PRESENCE OR ABSENCE OF ALCOHOL ADMINISTRATION. WE KNOW THAT A MAJOR COMPONENT OF THE SPECIFIC EXTERNAL ENVIRONMENT IS THE LIFESTYLE FACTOR OF ALCOHOL CONSUMPTION. THUS, UNDER THE COMPREHENSIVE SCHEMA OF THE EXPOSOME, ALCOHOL REPRESENTS AN ENVIRONMENTAL EXPOSURE THAT SHOULD BE CONSIDERED IN CONTEXT WITH OTHER INTERNAL AND EXTERNAL FACTORS TO UNDERSTAND CAUSES AND NATURE OF DISEASE PROGRESSION. THE OVERALL HYPOTHESIS OF OUR APPLICATION IS THE FOLLOWING: THE EXAMINATION OF ALCOHOL IN THE CONTEXT OF THE EXPOSOME WILL ALLOW US TO UNDERSTAND ITS ROLE MORE FULLY IN THE ETIOLOGY OF DISEASE AND THE SUBSEQUENT MANIFESTATIONS OF ALCOHOL-INDUCED HUMAN PATHOPHYSIOLOGY. THE ALCOHOL-EXPOSOME THEME OF THE CENTER IS UNIQUE AMONG ALCOHOL CENTERS AND HAS THE POTENTIAL TO BE HIGHLY TRANSLATIONAL. OUR INVESTIGATORS REPRESENT AN OUTSTANDING TEAM OF INTERDISCIPLINARY INVESTIGATORS THAT WILL BE SUPPORTED BY AN ADMINISTRATIVE CORE, A BIOSPECIMEN CORE, AND A PILOT PROJECTS CORE. ACORN INVESTIGATORS WILL HAVE ACCESS TO STATE-OF-THE ART FACILITIES AT UNMC, NEBRASKA MEDICAL CENTER AND UNIVERSITY OF NEBRASKA-LINCOLN. WE INCLUDE FACULTY FROM 5 DEPARTMENTS AND 3 COLLEGES. OUR PROPOSED SPECIFIC AIMS FOR THE ACORN ARE TO: 1) FACILITATE INTERDISCIPLINARY RESEARCH AND IDENTIFY FACTORS SO THAT WE CAN TRANSLATE IN HUMANS HOW AGE, NUTRITIONAL STATUS, CIGARETTE SMOKING, AND EXPOSURE TO PATHOGENS INTERACT IN THE PRESENCE OR ABSENCE OF ALCOHOL ADMINISTRATION. 2) CREATE A BIOSPECIMEN CORE TO AID CENTER INVESTIGATORS IN PROMOTION AND DEVELOPMENT OF TRANSLATIONAL ANIMAL AND HUMAN TISSUE AND CELL MODELS. 3) ENHANCE THE COLLABORATIVE ACORN ENVIRONMENT AND PROVIDE OPPORTUNITIES FOR FUNDING THROUGH TRAINING, SYMPOSIA, AND PILOT GRANTS. WORK ON OUR 4 RESEARCH PROJECTS, WITH PARTICIPATION OF THE ADMINISTRATION CORE AND THE BIOSPECIMEN CORE WILL ALLOW US TO REALIZE OUR GOALS. OVERALL, THIS NEW P50 WILL UTILIZE THE EXPERTISE AND KNOWLEDGE OF PAST RESEARCH EFFORTS TO EXAMINE HOW ALCOHOL, IN THE SETTING OF VARIOUS EXTERNAL AND INTERNAL ENVIRONMENTAL FACTORS WILL INFLUENCE DISEASE IN A VARIETY OF ORGANS AND HELP US SHAPE OUR FUTURE ANIMAL AND HUMAN STUDIES.

OPTIMAL STENT SELECTION FOR THE FEMOROPOPLITEAL ARTERY

OPTIMIZATION OF ANTISCHISTOSOMAL CHEMOTYPES

STEROL AND ISOPRENOID DISEASES CONSORTIUM

PARTNERSHIP FOR URBAN MCH LEADERSHIP COMMUNITY

PARTNERSHIP FOR URBAN MCH LEADERSHIP COMMUNITY

ADDRESSING STUDENT MENTAL HEALTH IN HIGH NEED SCHOOLS: NE SMH TRAINING PROGRAM

RII TRACK-2 FEC: COMPARATIVE GENOMICS AND PHENOMICS APPROACH TO DISCOVER GENES UNDERLYING HEAT STRESS RESILIENCE IN CEREALS

MECHANISMS OF GAP JUNCTION REGULATION

CENTER FOR THERMO-MEECHANICAL PROCESSING OF MATERIALS BY DESIGN

NEURAL IMMUNITY IN HIV DEMENTIA

REGULATION OF PHOTORECEPTOR NEUROTRANSMISSION

RYAN WHITE PART C OUTPATIENT EIS PROGRAM

SHAPING METALLIC SURFACES USING FEMTOSECOND LASER PULSES FOR THERMAL SYSTEM MANAGEMENT AND OTHER APPLICATIONS

STRENGTHENING HEALTHCARE INFECTION PREVENTION AND CONTROL AND IMPROVING PATIENT SAFETY IN THE UNITED STATES.

SMITH-LEVER PROJECT ABSTRACT FEDERAL AWARD PURPOSE: THE PURPOSE OF THE SMITH-LEVER 3(B) AND 3(C) FUNDING IS TO CONDUCT AGRICULTURAL EXTENSION WORK. THE COOPERATIVE EXTENSION PROGRAMS AT 1862 LAND-GRANT INSTITUTIONS IS ALIGNED WITH THE USDA STRATEGIC PLAN FOR FY 2022-2026. THE USDA STRATEGIC GOALS ARE AS FOLLOWS: COMBAT CLIMATE CHANGE TO SUPPORT AMERICA'S WORKING LANDS, NATURAL RESOURCES AND COMMUNITIES; ENSURE AMERICA'S AGRICULTURAL SYSTEM IS EQUITABLE, RESILIENT AND PROSPEROUS; FOSTER AN EQUITABLE AND COMPETITIVE MARKETPLACE FOR ALL AGRICULTURAL PRODUCERS; PROVIDE ALL AMERICANS SAFE, NUTRITIOUS FOOD; EXPAND OPPORTUNITIES FOR ECONOMIC DEVELOPMENT AND IMPROVE QUALITY OF LIFE IN RURAL AND TRIBAL COMMUNITIES; ATTRACT, INSPIRE AND RETAIN AN ENGAGED AND MOTIVATED WORKFORCE THAT'S PROUD TO REPRESENT USDA. ACTIVITIES TO BE PERFORMED: IN THE UNIVERSITY OF NEBRASKA-LINCOLN (UNL) INSTITUTE OF AGRICULTURE AND NATURAL RESOURCES (IANR), WE ARE ALL ABOUT PEOPLE AND THE FOOD, WATER AND NATURAL RESOURCES THAT SUSTAIN THEM. IANR INNOVATION IN RESEARCH, TEACHING, AND EXTENSION EDUCATION PLACES NEBRASKA ON THE LEADING EDGE OF FOOD PRODUCTION, ENVIRONMENTAL STEWARDSHIP, HUMAN NUTRITION, BUSINESS DEVELOPMENT, AND YOUTH ENGAGEMENT. COMPOSED OF THE COLLEGE OF AGRICULTURAL SCIENCES AND NATURAL RESOURCES (CASNR), THE AGRICULTURAL RESEARCH DIVISION (ARD), NEBRASKA EXTENSION, AND THE ARD AND EXTENSION COMPONENTS OF THREE DEPARTMENTS IN THE COLLEGE OF EDUCATION AND HUMAN SCIENCES; IANR IS COMMITTED TO GROWING THE FUTURE OF NEBRASKA'S PEOPLE, BUSINESSES, AND COMMUNITIES. STRATEGIC PLANNING IS INTEGRAL TO IANR'S FUNCTION AS A LAND-GRANT INSTITUTION, AND IT PRIDES ITSELF ON WORKING AS AN INTEGRATED SYSTEM AND COLLABORATIVE ENVIRONMENT ACROSS THE THREE MISSION AREAS. IANR STRIVES TO COMBINE RESEARCH, TEACHING AND EXTENSION IN A MULTIDISCIPLINARY, COLLABORATIVE ENVIRONMENT THAT ENCOURAGES THE BEST THINKING AND EXPERTISE FROM ACROSS THE UNIVERSITY AND PRIVATE ENTERPRISE TO ENSURE NEBRASKA'S COMPETITIVENESS IN A WORLD OF CHANGE AND CHALLENGE. SIX COMMUNITIES OF PRACTICE WERE FORMED IN 2011. FACULTY FROM ALL IANR DEPARTMENTS CAME TOGETHER AND RATHER THAN FOCUS ON INDIVIDUAL DEPARTMENT NEEDS, THEY AGREED TO FOCUS ON AREAS OF STRENGTH THAT THEY FELT THE INSTITUTION AS A WHOLE COULD BUILD UPON. IN 2020 FURTHER INTEGRATION OF MISSION AREAS AND DISCIPLINES LAUNCHED IN THE FORM OF IANR HUBS. HUBS FACILITATED AN INFORMAL CONNECTION AMONG PEOPLE AND UNITS WITHIN IANR THAT FURTHER LEVERAGE INSTITUTE CAPACITY TO DELIVER ON OUR MISSION. THAT TYPE OF BOLD COLLABORATION AND THINKING IS WHAT WAS NEEDED TO PROPEL NEBRASKA FORWARD. WE ARE STRIVING TO EXCEL IN THESE AREAS AND INVITE COLLABORATORS AND LEARNERS TO BECOME A PART OF THE CONVERSATION. WE WELCOME FEEDBACK, IDEAS, ENGAGEMENT, AND SUPPORT IN OUR ONGOING ENDEAVOR TO MAKE IANR A GLOBAL LEADER IN THESE KEY AREAS. IANR COMMUNITIES OF PRACTICE: COMPUTATIONAL SCIENCES DRIVERS OF ECONOMIC VITALITY FOR NEBRASKA HEALTH HUMANS HEALTHY SYSTEMS FOR AGRICULTURAL PRODUCTION AND NATURAL RESOURCES SCIENCE LITERACY STRESS BIOLOGY IANR HUBS: NEBRASKA INTEGRATED BEEF SYSTEMS RURAL PROSPERITY NEBRASKA WATER AND INTEGRATED CROPPING SYSTEMS IN 2018 STRATEGIC TWO-WAY DIALOGUE MOVED TO A NEW, HIGHER PLANE AS VISION FOR 2025 WAS IMPLEMENTED TO ENSURE NEBRASKA'S COMPETITIVENESS IN A WORLD OF CHANGE AND CHALLENGE. THIS VISIONING PROCESS WAS CREATED TO DETERMINE HOW IANR WILL CONTRIBUTE TO THE CRITICAL NEED OF DOUBLING THE WORLD'S FOOD SUPPLY IN ORDER TO FEED OVER 9 BILLION PEOPLE; ADDRESS THE SHIFTING CLIMATE AND ENVIRONMENTAL CONDITIONS; RESPOND TO THE INCREASING NEED FOR ENERGY SOURCES; AND CONSIDER HOW TO HELP INCREASE ECONOMIC INCOME OPPORTUNITIES FOR COMMUNITIES AND THUS THE LONG-TERM ECONOMIC GROWTH FOR NEBRASKA. IN NEBRASKA, ONE IN FOUR JOBS IS DIRECTLY TIED TO AGRICULTURE OR AGRIBUSINESS, AND THE STATE STRIVES TO INCREASE JOB OPPORTUNITIES IN THIS FIELD OF EXPERTISE. IANR INFORMS AND ENGAGES PARTNERS AND CLIENTELE IN OUR FOCUS AREAS OF FOOD, FUEL, WATER, LANDSCAPES, AND PEOPLE. THESE FIVE FOCUS AREAS ARE REPRESENTATIVE OF THE SOCIETAL CHALLENGE AREAS OF THE NATIONAL INSTITUTE OF FOOD AND AGRICULTURE (NIFA). FOR EXAMPLE, IN THE NEBRASKA PLANNING PROCESS "FOOD" REPRESENTS THE CONTINUUM OF FOOD TO FORK, WHICH INCLUDES PRODUCTION, FOOD SECURITY AND HUNGER, CHILDHOOD OBESITY, NUTRITION AND FOOD SAFETY, AND SCIENCE/FOOD LITERACY. RESILIENT FOOD PRODUCTION AND ECOLOGICAL SYSTEMS REPRESENTS THE PRODUCTIVITY AND SUSTAINABILITY OF ALL OF OUR NATURAL RESOURCES. WATER IS HIGHLIGHTED BECAUSE OF THE IMPORTANCE OF WATER TO OUR AGRICULTURAL AND NATURAL RESOURCE SYSTEMS IN NEBRASKA. FOSTERING HEALTHY AND PRODUCTIVE PEOPLE REPRESENTS THE WELL-BEING OF CHILDREN, YOUTH, AND FAMILIES AS THEY INTERACT WITH THEIR ENVIRONMENT. DELIVERABLES AND EXPECTED OUTCOMES: THE CAPACITY FUNDING IANR RECEIVES IS ALLOCATED WITHIN TWO KEY, CRITICAL ISSUES TO ADDRESS THE ABOVE FOCUS AREAS. 1. RESILIENT FOOD PRODUCTION AND ECOLOGICAL SYSTEMS THIS PROGRAM FOCUSES ON USING BASIC AND APPLIED RESEARCH IN THE LIFE/AGRICULTURAL SCIENCES TO GENERATE KNOWLEDGE CRITICAL TO MAXIMIZING PRODUCTIVITY IN ANIMAL/PLANT AGRICULTURE, ENGINEERING, NATURAL RESOURCES, CLIMATE, AND SUSTAINABLE ENERGY. RESEARCH EFFORTS SPAN THE BASIC/FUNDAMENTAL TO THE APPLIED, RELATING TO CROP/ANIMAL SYSTEMS, BIOENERGY FEEDSTOCKS, AND THE NATURAL LANDSCAPES IN WHICH THOSE SYSTEMS EXIST. EXTENSION PROGRAMS CONTINUE TO TRANSFER NEW KNOWLEDGE TO PRODUCERS, HELPING THEM OPTIMIZE PRODUCTIVITY WHILE ENSURING FINANCIAL AND ENVIRONMENTAL SUSTAINABILITY OF NEBRASKA'S FARMS/RANCHES. UNDERGRADUATE/GRADUATE EDUCATION PROGRAMS SUPPORT RESEARCH AND EXTENSION EFFORTS, ENSURING A HIGHLY EDUCATED WORKFORCE ESSENTIAL TO MODERN AGRICULTURE. SCIENCE EMPHASIS AREAS: AGROCLIMATE SCIENCE BIOECONOMY, BIOENERGY AND BIOPRODUCTS ENVIRONMENTAL SYSTEMS 2. FOSTERING HEALTHY AND PRODUCTIVE PEOPLE THIS PROGRAM FOCUSES ON USING BASIC AND APPLIED RESEARCH IN THE LIFE/AGRICULTURAL SCIENCES TO GENERATE KNOWLEDGE CRITICAL TO MAXIMIZING PRODUCTIVITY IN FOOD SCIENCES; BUSINESS/COMMUNITY VITALITY; ENTREPRENEURSHIP; HEALTHY LIVING; AND DEVELOPMENT AND SUCCESS OF YOUNG CHILDREN, YOUTH, AND FAMILIES. RESEARCH EFFORTS SPAN THE BASIC/FUNDAMENTAL TO THE APPLIED/TRANSLATIONAL, RELATING TO NUTRITION/HE ALTH, FOOD SAFETY, EARLY CHILDHOOD, YOUTH DEVELOPMENT, FAMILY STRENGTHENING, AND COMMUNITY CAPACITY BUILDING. EXTENSION PROGRAMS WILL ENGAGE CLIENTELE BY TRANSLATING EXISTING AND NEW RESEARCH TO NEBRASKANS THAT OPTIMIZE PRODUCTIVITY AND LIKELIHOOD OF SUCCESS. THESE EFFORTS WILL BE SUPPORTED BY UNDERGRADUATE/GRADUATE EDUCATION DESIGNED TO CONTRIBUTE THE STATE'S LONG-TERM ECONOMIC GROWTH. SCIENCE EMPHASIS AREAS: EDUCATION AND MULTICULTURAL ALLIANCES FAMILY <(>&<)> CONSUMER SCIENCES FOOD SAFETY HUMAN NUTRITION YOUTH DEVELOPMENT FOR A COMPREHENSIVE LIST OF ALL OUTCOMES, WE WELCOME THE REVIEW OF IANR'S ANNUAL REPORT OF ACCOMPLISHMENTS AND RESULTS. INTENDED BENEFICIARIES: AS NEBRASKA'S RESIDENTS ARE THE PRIMARY BENEFICIARIES AND STAKEHOLDERS, THERE IS AN ONGOING, TWO-WAY DIALOGUE TO ENSURE THAT IANR'S PRIORITIES REFLECT THE NEEDS OF THE STATE. SUBRECIPIENT ACTIVITIES: N/A

PURPOSE: THE PURPOSE OF THE SMITH-LEVER 3(B) AND 3(C) FUNDING IS TO CONDUCT AGRICULTURAL EXTENSION WORK. THE COOPERATIVE EXTENSION PROGRAMS AT 1862 LAND-GRANT INSTITUTIONS IS ALIGNED WITH THE USDA STRATEGIC PLAN FOR FY 2022-2026. ACTIVITIES TO BE PERFORMED: THE UNIVERSITY OF NEBRASKA-LINCOLN (UNL) INSTITUTE OF AGRICULTURE AND NATURAL RESOURCES (IANR) IS COMMITTED TO GROWING THE FUTURE OF NEBRASKA'S PEOPLE, BUSINESSES, AND COMMUNITIES. IANR STRIVES TO COMBINE RESEARCH, TEACHING AND EXTENSION IN A MULTIDISCIPLINARY, COLLABORATIVE ENVIRONMENT THAT ENCOURAGES THE BEST THINKING AND EXPERTISE FROM ACROSS THE UNIVERSITY AND PRIVATE ENTERPRISE TO ENSURE NEBRASKA'S COMPETITIVENESS IN A WORLD OF CHANGE AND CHALLENGE. SIX COMMUNITIES OF PRACTICE WERE FORMED IN 2011 (COMPUTATIONAL SCIENCES, DRIVERS OF ECONOMIC VITALITY, HEALTH HUMANS, HEALTHY SYSTEMS FOR AG. PRODUCTION AND NATURAL RESOURCES, SCIENCE LITERACY, STRESS BIOLOGY). IN 2020 FURTHER INTEGRATION OF MISSION AREAS AND DISCIPLINES LAUNCHED IN THE FORM OF IANR HUBS (INTEGRATED BEEF SYSTEMS, RURAL PROSPERITY, WATER AND INTEGRATED CROPPING SYSTEMS). HUBS FACILITATED AN INFORMAL CONNECTION AMONG PEOPLE AND UNITS WITHIN IANR THAT FURTHER LEVERAGE INSTITUTE CAPACITY TO DELIVER ON OUR MISSION. VISION FOR 2025 WAS IMPLEMENTED TO DETERMINE HOW IANR WILL CONTRIBUTE TO THE CRITICAL NEED OF DOUBLING THE WORLD'S FOOD SUPPLY IN ORDER TO FEED OVER 9 BILLION PEOPLE; ADDRESS THE SHIFTING CLIMATE AND ENVIRONMENTAL CONDITIONS; RESPOND TO THE INCREASING NEED FOR ENERGY SOURCES; AND CONSIDER HOW TO HELP INCREASE ECONOMIC INCOME OPPORTUNITIES FOR COMMUNITIES AND THUS THE LONG-TERM ECONOMIC GROWTH FOR NEBRASKA. IN NEBRASKA, ONE IN FOUR JOBS IS DIRECTLY TIED TO AGRICULTURE OR AGRIBUSINESS, AND THE STATE STRIVES TO INCREASE JOB OPPORTUNITIES IN THIS FIELD OF EXPERTISE. IANR INFORMS AND ENGAGES PARTNERS AND CLIENTELE IN OUR FOCUS AREAS OF FOOD, FUEL, WATER, LANDSCAPES, AND PEOPLE. THESE FIVE FOCUS AREAS ARE REPRESENTATIVE OF THE SOCIETAL CHALLENGE AREAS OF THE NATIONAL INSTITUTE OF FOOD AND AGRICULTURE (NIFA). FOR EXAMPLE, IN THE NEBRASKA PLANNING PROCESS 'FOOD' REPRESENTS THE CONTINUUM OF FOOD TO FORK, WHICH INCLUDES PRODUCTION, FOOD SECURITY AND HUNGER, CHILDHOOD OBESITY, NUTRITION AND FOOD SAFETY, AND SCIENCE/FOOD LITERACY. RESILIENT FOOD PRODUCTION AND ECOLOGICAL SYSTEMS REPRESENTS THE PRODUCTIVITY AND SUSTAINABILITY OF ALL OF OUR NATURAL RESOURCES. WATER IS HIGHLIGHTED BECAUSE OF THE IMPORTANCE OF WATER TO OUR AGRICULTURAL AND NATURAL RESOU RCE SYSTEMS IN NEBRASKA. FOSTERING HEALTHY AND PRODUCTIVE PEOPLE REPRESENTS THE WELL-BEING OF CHILDREN, YOUTH, AND FAMILIES AS THEY INTERACT WITH THEIR ENVIRONMENT. DELIVERABLES AND EXPECTED OUTCOMES: THE CAPACITY FUNDING IANR RECEIVES IS ALLOCATED WITHIN TWO KEY, CRITICAL ISSUES TO ADDRESS THE ABOVE FOCUS AREAS. RESILIENT FOOD PRODUCTION AND ECOLOGICAL SYSTEMS: RESEARCH EFFORTS SPAN THE BASIC/FUNDAMENTAL TO THE APPLIED, RELATING TO CROP/ANIMAL SYSTEMS, BIOENERGY FEEDSTOCKS, AND THE NATURAL LANDSCAPES IN WHICH THOSE SYSTEMS EXIST. EXTENSION PROGRAMS CONTINUE TO TRANSFER NEW KNOWLEDGE TO PRODUCERS, HELPING THEM OPTIMIZE PRODUCTIVITY WHILE ENSURING FINANCIAL AND ENVIRONMENTAL SUSTAINABILITY OF NEBRASKA'S FARMS/RANCHES. FOSTERING HEALTHY AND PRODUCTIVE PEOPLE: RESEARCH EFFORTS SPAN THE BASIC/FUNDAMENTAL TO THE APPLIED/TRANSLATIONAL, RELATING TO NUTRITION/HEALTH, FOOD SAFETY, EARLY CHILDHOOD, YOUTH DEVELOPMENT, FAMILY STRENGTHENING, AND COMMUNITY CAPACITY BUILDING. EXTENSION PROGRAMS WILL ENGAGE CLIENTELE BY TRANSLATING EXISTING AND NEW RESEARCH TO NEBRASKANS THAT OPTIMIZE PRODUCTIVITY AND LIKELIHOOD OF SUCCESS. FOR A COMPREHENSIVE LIST OF ALL OUTCOMES, WE WELCOME THE REVIEW OF IANR'S ANNUAL REPORT OF ACCOMPLISHMENTS AND RESULTS. BENEFICIARIES: AS NEBRASKA'S RESIDENTS ARE THE PRIMARY BENEFICIARIES AND STAKEHOLDERS, THERE IS AN ONGOING, TWO-WAY DIALOGUE TO ENSURE THAT IANR'S PRIORITIES REFLECT THE NEEDS OF THE STATE.

PURPOSE: THE PURPOSE OF THE SMITH?LEVER 3(B) AND 3(C) FUNDING IS TO CONDUCT AGRICULTURAL EXTENSION WORK. THE COOPERATIVE EXTENSION PROGRAMS AT 1862 LAND?GRANT INSTITUTIONS IS ALIGNED WITH THE USDA STRATEGIC PLAN AND THE USDA SCIENCE AND RESEARCH STRATEGY. ACTIVITIES TO BE PERFORMED: THE UNIVERSITY OF NEBRASKA?LINCOLN (UNL) INSTITUTE OF AGRICULTURE AND NATURAL RESOURCES (IANR) IS COMMITTED TO PEOPLE AND THE FOOD, WATER AND NATURAL RESOURCES THAT SUSTAIN THEM. IANR INNOVATION IN RESEARCH, TEACHING, AND EXTENSION PLACES NEBRASKA ON THE LEADING EDGE OF FOOD PRODUCTION, ENVIRONMENTAL STEWARDSHIP, HUMAN NUTRITION, BUSINESS DEVELOPMENT, AND YOUTH ENGAGEMENT. IANR STRIVES TO INTEGRATE RESEARCH, EDUCATION AND EXTENSION AND PARTNER WITH STAKEHOLDERS TO DEVELOP A DIVERSE NEXT GENERATION WORKFORCE READY TO TACKLE CURRENT AND EMERGING CHALLENGES RELATED TO AGRICULTURE, NATURAL RESOURCES, CLIMATE, AND HUMAN HEALTH WHILE ENSURING AN INCLUSIVE ENVIRONMENT THAT ENCOURAGES INNOVATION AND ENTREPRENEURSHIP. FACULTY FROM ACROSS IANR'S DEPARTMENTS AND ACADEMIC CENTERS FOCUS ON AREAS OF RELEVANCE AND STRENGTHS THAT THE INSTITUTION AS A WHOLE CAN BUILD UPON. A 5?YEAR STRATEGIC DIRECTION WAS LAUNCHED IN 2024 TO ENSURE NEBRASKA'S COMPETITIVENESS IN A WORLD OF CHANGE AND CHALLENGE. THIS VISIONING PROCESS DETERMINED HOW IANR WOULD CONTRIBUTE TO THE CRITICAL NEED OF DOUBLING THE WORLD'S FOOD SUPPLY TO FEED OVER 9 BILLION PEOPLE; ADDRESS THE SHIFTING CLIMATE AND ENVIRONMENTAL CONDITIONS; RESPOND TO THE INCREASING NEED FOR FIBER, FEED AND ENERGY SOURCES UNDER DWINDLING NATURAL RESOURCES; REDUCE WASTE; CREATE A DIVERSE, INCLUSIVE AND EQUITABLE ENVIRONMENT; AND CONSIDER HOW TO HELP INCREASE ECONOMIC INCOME OPPORTUNITIES FOR COMMUNITIES AND THUS THE LONG?TERM ECONOMIC GROWTH FOR NEBRASKA. IN NEBRASKA, ONE IN FOUR JOBS IS DIRECTLY TIED TO AGRICULTURE OR AGRIBUSINESS, AND THE STATE STRIVES TO INCREASE JOB OPPORTUNITIES IN THIS FIELD OF EXPERTISE. IANR IS POSITIONED SQUARELY AT THE NEXUS OF FOOD, ENERGY, WATER, HEALTH, AND COMMUNITY. IN NEBRASKA, THESE SECTORS ARE INSEPARABLY LINKED AND THEY ARE VITAL TO NEBRASKA'S ABILITY TO THRIVE. TRUE TO OUR LAND?GRANT MISSION, IANR WORKS WITH NEBRASKANS TO INCREASE ACCESS TO A POWERFUL COMBINATION OF LEARNING, RESEARCH, AND EXTENSION. DELIVERABLES AND EXPECTED OUTCOMES: THE CAPACITY FUNDING IANR RECEIVES IS ALLOCATED WITHIN TWO KEY, CRITICAL ISSUES TO ADDRESS THE ABOVE FOCUS AREAS. RESILIENT FOOD PRODUCTION AND ECOLOGICAL SYSTEMS: THIS PROGRAM FOCUSES ON USING BASIC AND APPLIED RESEARCH IN THE LIFE/AGRICULTURAL SCIENCES TO GENERATE KNOWLEDGE CRITICAL TO MAXIMIZING PRODUCTIVITY IN ANIMAL/PLANT AGRICULTURE, ENGINEERING, NATURAL RESOURCES, CLIMATE, AND SUSTAINABLE ENERGY. EXTENSION PROGRAMS CONTINUE TO TRANSFER NEW KNOWLEDGE TO PRODUCERS, HELPING THEM OPTIMIZE PRODUCTIVITY WHILE ENSURING FINANCIAL AND ENVIRONMENTAL SUSTAINABILITY OF NEBRASKA'S FARMS/RANCHES. UNDERGRADUATE/GRADUATE EDUCATION PROGRAMS SUPPORT RESEARCH AND EXTENSION EFFORTS, ENSURING A HIGHLY EDUCATED WORKFORCE ESSENTIAL TO MODERN AGRICULTURE. FOSTERING HEALTHY AND PRODUCTIVE PEOPLE: THIS PROGRAM FOCUSES ON USING BASIC AND APPLIED RESEARCH IN THE LIFE/AGRICULTURAL SCIENCES TO GENERATE KNOWLEDGE CRITICAL TO MAXIMIZING PRODUCTIVITY IN FOOD SCIENCES; BUSINESS/COMMUNITY VITALITY; ENTREPRENEURSHIP; HEALTHY LIVING; AND DEVELOPMENT AND SUCCESS OF YOUNG CHILDREN, YOUTH, AND FAMILIES. EXTENSION PROGRAMS WILL ENGAGE CLIENTELE BY TRANSLATING EXISTING AND NEW RESEARCH TO NEBRASKANS THAT OPTIMIZE PRODUCTIVITY AND LIKELIHOOD OF SUCCESS. THESE EFFORTS WILL BE SUPPORTED BY UNDERGRADUATE/GRADUATE EDUCATION DESIGNED TO CONTRIBUTE TO THE STATE'S LONG?TERM ECONOMIC GROWTH. FOR A COMPREHENSIVE LIST OF ALL OUTCOMES, WE WELCOME THE REVIEW OF IANR'S ANNUAL REPORT OF ACCOMPLISHMENTS AND RESULTS. BENEFICIARIES: AS NEBRASKA'S RESIDENTS ARE THE PRIMARY BENEFICIARIES AND STAKEHOLDERS, THERE IS AN ONGOING, TWO?WAY DIALOGUE TO ENSURE THAT IANR'S PRIORITIES REFLECT THE NEEDS OF THE STATE.

THE PURPOSE OF THE SMITH-LEVER 3(B) AND 3(C) FUNDING IS TO CONDUCT AGRICULTURAL EXTENSION WORK. THE COOPERATIVE EXTENSION PROGRAMS AT 1862 LAND-GRANT INSTITUTIONS IS ALIGNED WITH THE USDA STRATEGIC PLAN AND THE USDA SCIENCE AND RESEARCH STRATEGY. ACTIVITIES TO BE PERFORMED: THE UNIVERSITY OF NEBRASKA-LINCOLN (UNL) INSTITUTE OF AGRICULTURE AND NATURAL RESOURCES (IANR) IS COMMITTED TO PEOPLE AND THE FOOD, WATER AND NATURAL RESOURCES THAT SUSTAIN THEM. IANR INNOVATION IN RESEARCH, TEACHING, AND EXTENSION PLACES NEBRASKA ON THE LEADING EDGE OF FOOD PRODUCTION, ENVIRONMENTAL STEWARDSHIP, HUMAN NUTRITION, BUSINESS DEVELOPMENT, AND YOUTH ENGAGEMENT. IANR STRIVES TO INTEGRATE RESEARCH, EDUCATION AND EXTENSION AND PARTNER WITH STAKEHOLDERS TO DEVELOP A DIVERSE NEXT GENERATION WORKFORCE READY TO TACKLE CURRENT AND EMERGING CHALLENGES RELATED TO AGRICULTURE, NATURAL RESOURCES, CLIMATE, AND HUMAN HEALTH WHILE ENSURING AN INCLUSIVE ENVIRONMENT THAT ENCOURAGES INNOVATION AND ENTREPRENEURSHIP. FACULTY FROM ACROSS IANR'S DEPARTMENTS AND ACADEMIC CENTERS FOCUS ON AREAS OF RELEVANCE AND STRENGTHS THAT THE INSTITUTION AS A WHOLE CAN BUILD UPON. A 5-YEAR STRATEGIC DIRECTION WAS LAUNCHED IN 2024 TO ENSURE NEBRASKA'S COMPETITIVENESS IN A WORLD OF CHANGE AND CHALLENGE. THIS VISIONING PROCESS DETERMINED HOW IANR WOULD C ONTRIBUTE TO THE CRITICAL NEED OF DOUBLING THE WORLD'S FOOD SUPPLY TO FEED OVER 9 BILLION PEOPLE; ADDRESS THE SHIFTING CLIMATE AND ENVIRONMENTAL CONDITIONS; RESPOND TO THE INCREASING NEED FOR FIBER, FEED AND ENERGY SOURCES UNDER DWINDLING NATURAL RESOURCES; REDUCE WASTE; CREATE A DIVERSE, INCLUSIVE AND EQUITABLE ENVIRONMENT; AND CONSIDER HOW TO HELP INCREASE ECONOMIC INCOME OPPORTUNITIES FOR COMMUNITIES AND THUS THE LONG-TERM ECONOMIC GROWTH FOR NEBRASKA. IN NEBRASKA, ONE IN FOUR JOBS IS DIRECTLY TIED TO AGRICULTURE OR AGRIBUSINESS, AND THE STATE STRIVES TO INCREASE JOB OPPORTUNITIES IN THIS FIELD OF EXPERTISE. IANR IS POSITIONED SQUARELY AT THE NEXUS OF FOOD, ENERGY, WATER, HEALTH, AND COMMUNITY. IN NEBRASKA, THESE SECTORS ARE INSEPARABLY LINKED AND THEY ARE VITAL TO NEBRASKA'S ABILITY TO THRIVE. TRUE TO OUR LAND-GRANT MISSION, IANR WORKS WITH NEBRASKANS TO INCREASE ACCESS TO A POWERFUL COMBINATION OF LEARNING, RESEARCH, AND EXTENSION. DELIVERABLES AND EXPECTED OUTCOMES: THE CAPACITY FUNDING IANR RECEIVES IS ALLOCATED WITHIN TWO KEY, CRITICAL ISSUES TO ADDRESS THE ABOVE FOCUS AREAS. RESILIENT FOOD PRODUCTION AND ECOLOGICAL SYSTEMS: THIS PROGRAM FOCUSES ON USING BASIC AND APPLIED RESEARCH IN THE LIFE/AGRICULTURAL SCIENCES TO GENERATE KNOWLEDGE CRITICAL TO MAXIMIZING PRODUCTIVITY IN ANIMAL/PLANT AGRICULTURE, ENGINEERING, NATURAL RESOURCES, CLIMATE, AND SUSTAINABLE ENERGY. EXTENSION PROGRAMS CONTINUE TO TRANSFER NEW KNOWLEDGE TO PRODUCERS, HELPING THEM OPTIMIZE PRODUCTIVITY WHILE ENSURING FINANCIAL AND ENVIRONMENTAL SUSTAINABILITY OF NEBRASKA'S FARMS/RANCHES. UNDERGRADUATE/GRADUATE EDUCATION PROGRAMS SUPPORT RESEARCH AND EXTENSION EFFORTS, ENSURING A HIGHLY EDUCATED WORKFORCE ESSENTIAL TO MODERN AGRICULTURE. FOSTERING HEALTHY AND PRODUCTIVE PEOPLE: THIS PROGRAM FOCUSES ON USING BASIC AND APPLIED RESEARCH IN THE LIFE/AGRICULTURAL SCIENCES TO GENERATE KNOWLEDGE CRITICAL TO MAXIMIZING PRODUCTIVITY IN FOOD SCIENCES; BUSINESS/COMMUNITY VITALITY; ENTREPRENEURSHIP; HEALTHY LIVING; AND DEVELOPMENT AND SUCCESS OF YOUNG CHILDREN, YOUTH, AND FAMILIES. EXTENSION PROGRAMS WILL ENGAGE CLIENTELE BY TRANSLATING EXISTING AND NEW RESEARCH TO NEBRASKANS THAT OPTIMIZE PRODUCTIVITY AND LIKELIHOOD OF SUCCESS. THESE EFFORTS WILL BE SUPPORTED BY UNDERGRADUATE/GRADUATE EDUCATION DESIGNED TO CONTRIBUTE TO THE STATE'S LONG-TERM ECONOMIC GROWTH. FOR A COMPREHENSIVE LIST OF ALL OUTCOMES, WE WELCOME THE REVIEW OF IANR'S ANNUAL REPORT OF ACCOMPLISHMENTS AND RESULTS. BENEFICIARIES: AS NEBRASKA'S RESIDENTS ARE THE PRIMARY BENEFICIARIES AND STAKEHOLDERS, THERE IS AN ONGOING, TWO-WAY DIALOGUE TO ENSURE THAT IANR'S PRIORITIES REFLECT THE NEEDS OF THE STATE.

NANOMEDICINE AND NEUROAIDS

FY22 JOINT COOPERATIVE EXTENSION PROGRAMS AT 1862 LAND-GRANTINSTITUTIONS AND UNIVERSITY OF THE DISTRICT OF COLUMBIA PUBLIC POSTSECONDARY EDUCATION REORGANIZATION ACT PROGRAM

FY19 JOINT COOPERATIVE EXTENSION PROGRAMS AT 1862 LAND-GRANT INSTITUTIONS (SMITH LEVER 3BC)

ABERRANT DNA REPAIR AND LUPUS

FY20 JOINT COOPERATIVE EXTENSION PROGRAMS AT 1862 LAND-GRANT INSTITUTIONS AND UNIVERSITY OF THE DISTRICT OF COLUMBIA PUBLIC POSTSECONDARY EDUCATION REORGANIZATION ACT PROGRAM

FY21 JOINT COOPERATIVE EXTENSION PROGRAMS AT 1862 LAND-GRANT INSTITUTIONS AND UNIVERSITY OF THE DISTRICT OF COLUMBIA PUBLIC POSTSECONDARY EDUCATION REORGANIZATION ACT PROGRAM (SMITH LEVER CAPACITY)

NEBRASKA CENTER FOR NANOMEDICINE

AREA HEALTH EDUCATION CENTERS POINT OF SERVICE MAINTENANCE AND ENHANCEMENT

PRODRUG FORMULATIONS CREATE SUSTAINED RELEASE ANTIRETROVIRALS

MRI UNIV AFFILIATED INTERDISCIPLINARY TRAINING PROGRAM

MITOCHONDRIAL DYSFUNCTION OXIDATIVE DAMAGE AND INFLAMMATION IN CLAUDICATION

ADAPTIVE NEUROSTIMULATION TO RESTORE SLEEP IN PARKINSON'S DISEASE: AN INVESTIGATION OF STN LFP BIOMARKERS IN SLEEP DYSREGULATION AND REPAIR

FFY 2017 SMITH LEVER 3BC

FY18 SMITH LEVER 3BC

FY 2014 SMITH LEVER 3BC

THE MOLECULAR BIOLOGY OF NEUROSENSORY SYSTEMS

TECHNOLOGIES FOR HEMOSTASIS AND STABILIZATION OF THE ACUTE TRAUMATIC WOUND

** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** RUMINANT-BASED AGRICULTURE IS EXPECTED TO CONTINUE TO BE A MAJOR CONTRIBUTOR TO FEEDING THE INCREASING POPULATION. HOWEVER, RUMINANT AGRICULTURE IS ALSO ONE OF THE MAJOR SOURCES METHANE, A POTENTGREENHOUSEAND CONTRIBUTER TO CLIMATE CHANGE. MICROBIAL METHANE PRODUCTIONIN RUMINANTS IS INFLUENCED BY MANY FACTORS MOST NOTABLY ANIMAL GENETICS, DIET, AND THE GUT MICROBES. HOWEVER, OUR UNDERSTANDING OF MICROBIAL PROCESSES WITHIN RUMINANTS ACROSS GENE POOLS AND IN DIET COMBINATIONS THAT LEAD TO METHANE PRODUCTION OR INHIBITION IS LIMITED. THEREFORE, UNDERSTANDING FACTORS AND PROCESSES THAT UNDERPIN MICROBIALLY MEDIATED METHANE CHANGES, AND ASSOCIATED INTERACTIONS IS CRITICAL TOWARDS MITIGATING METHANE EMISSIONS. THIS PROPOSAL ATTEMPTS TO UNDERSTAND GENETIC, MANAGEMENT, DIET, AND MICROBIAL RELATIONSHIPS TO DEVELOP SCIENCE-BASED DIETARY AND MANAGEMENT INTERVENTION STRATEGIES TO REDUCE GREENHOUSE GAS EMISSION FROM CATTLE. ADDITIONALLY, THIS APPLICATION PLANS TO DEVELOP NOVEL MICROBIOME STRATEGIES BASED ON MICROBIAL COLONIZATION IN THE GUT OF CATTLE. THE PROJECT WILL DELIVER RESEARCH FINDINGS AND MANAGEMENT STRATEGIES TO REDUCE METHANE PRODUCTION IN DAIRY AND BEEF CATTLE PRODUCTION SYSTEMS TO EFFECT CHANGE IN MANAGEMENT THROUGH OUTREACH. THIS WORK IS EXPECTED TO TRANSLATE TO THE DEVELOPMENT OF MANAGEMENT AND MICROBIOME ESTABLISHMENT STRATEGIES THAT REDUCE METHANE EMISSION AND ESTABLISH AN NETWORK THAT WILL IMPROVE THE CAPACITY NATIONWIDE TO EDUCATE STAKEHOLDER CONCERNS AND PROVIDE TOOLS AND MATERIAL THAT WILL HELP PRODUCERS TO ASSESS AND ADOPT PRACTICES THAT MITIGATE METHANE EMISSION.

SHIGA-TOXIGENIC ESCHERICHIA COLI (STEC) IN THE BEEF CHAIN: ASSESSING & MITIGATING THE RISK BY TRANSLATIONAL SCIENCE, EDUCATION & OUTREACH

SHIGA-TOXIGENIC ESCHERICHIA COLI (STEC) IN THE BEEF CHAIN: ASSESSING & MITIGATING THE RISK BY TRANSLATIONAL SCIENCE, EDUCATION & OUTREACH

SHIGA-TOXIGENIC ESCHERICHIA COLI (STEC) IN THE BEEF CHAIN: ASSESSING & MITIGATING THE RISK BY TRANSLATIONAL SCIENCE, EDUCATION & OUTREACH

FY2012 SMITH LEVER 3BC

RESEARCH NETWORKS FOCUSED ON CRITICAL PROBLEMS OF EDUCATION POLICY AND PRACTICE (NETWORKS)

HIV THERANOSTIC

"(CONGRESSIONAL) HIGH-ENERGY LASER DETECTION, INSPECTION, AND NON-DESTRUCTIVE TESTING PHASE II"

NEBRASKA CENTER FOR VIROLOGY

TRANSLESION SYNTHESIS DNA POLYMERASES AND GENOME INSTABILITY

NEBRASKA CENTER FOR CELLULAR SIGNALING

RAMIPRIL TREATMENT OF CLAUDICATION: OXIDATIVE DAMAGE AND MUSCLE FIBROSIS

FY 2013 SMITH LEVER 3BC

HARNESSING GLYCOPROTEOMICS AND GLYCOMICS TO UNDERSTAND CARDIAC BIOLOGY AND DISEASE - ABSTRACT OUR RESEARCH PROGRAM DEVELOPS AND APPLIES INNOVATIVE MASS SPECTROMETRY TECHNOLOGIES, BIOINFORMATICS TOOLS, AND METHODOLOGIES TO TRANSFORM OUR UNDERSTANDING OF CELL SURFACE PROTEINS AND GLYCANS AND ANSWER OUTSTANDING QUESTIONS IN STEM CELL BIOLOGY AND CARDIAC PATHOLOGY. OUR ANALYTICAL PLATFORMS PROMOTE THE DEVELOPMENT OF NEW REAGENTS AND STRATEGIES TO IMPROVE THE QUALITY AND HOMOGENEITY OF STEM CELL-DERIVED CARDIOMYOCYTES FOR RESEARCH AND CLINICAL APPLICATIONS AND THE DISCOVERY OF STRATEGIES TO MONITOR AND TREAT PATIENTS WITH ADVANCED HEART FAILURE. SPECIFICALLY, OUR APPROACHES ENABLE THE IDENTIFICATION, CHARACTERIZATION, AND QUANTIFICATION OF CELL SURFACE GLYCOPROTEINS AND GLYCANS FROM SMALL NUMBERS OF HUMAN CELLS. TO DATE, WE HAVE DEVELOPED NEW MARKERS FOR IDENTIFYING CARDIOMYOCYTES WITH HIGH SPECIFICITY AND SELECTING MATURATION STAGE-SPECIFIC STEM CELL DERIVED CARDIOMYOCYTES TO ENABLE REPRODUCIBLE ASSESSMENT AND ISOLATION OF FUNCTIONALLY-DEFINED CELLS. APPLYING OUR TECHNOLOGIES TO PRIMARY HUMAN HEART TISSUE, WE HAVE BEGUN TO DEVELOP CELL-TYPE SPECIFIC VIEWS OF THE CELL SURFACE PROTEOME AND GLYCOME WITHIN NORMAL AND FAILING HEARTS. WE HAVE ALSO DEVELOPED INNOVATIVE BIOINFORMATICS TOOLS TO INFORM OUR NEXT LEVEL OF TECHNOLOGY DEVELOPMENT TO ENHANCE OUR CAPABILITIES AND IMPROVE THE SPEED AND ACCURACY WITH WHICH WE ANALYZE OUR MASS SPECTROMETRY DATA. THE PROPOSED STUDIES BUILD ON THESE EXPERIENCES TO: 1) DEVELOP THE NEXT GENERATION TECHNOLOGY THAT WILL PROVIDE UNPARALLELED SPECIFICITY REGARDING THE MOLECULAR PHENOTYPES PRESENTED AT THE CELL SURFACE, INFORMATION THAT IS NOT POSSIBLE TO OBTAIN BY ANY CURRENT METHOD, 2) DEVELOP MARKER PANELS THAT ENABLE THE ASSESSMENT AND SELECTION OF CHAMBER- AND MATURATION-STAGE SPECIFIC STEM CELL DERIVED CARDIOMYOCYTES WITHOUT GENETIC EDITING, 3) DEFINE THE CELL-TYPE SPECIFIC RECEPTORS, MEMBRANE- BOUND LIGANDS AND SECRETED FACTORS PRESENT IN THE NORMAL HUMAN HEART AND HOW THEY CHANGE IN DISEASE TO PROVIDE NEW UNDERSTANDING OF INTERCELLULAR SIGNALING AND INFORM THE DEVELOPMENT OF REMOTE SENSING MARKERS TO BENEFIT THE CARE OF PATIENTS WITH ADVANCED HEART FAILURE. THE IMPACT FROM THE PROPOSED STUDIES LIES WITHIN FUTURE APPLICATIONS AND MECHANISTIC STUDIES THAT WILL BE POSSIBLE BASED ON THE APPROACHES AND DATA THAT WE GENERATE. AS OUR PROGRAM EVOLVES TO PURSUE MECHANISTIC AND TRANSLATIONAL STUDIES OF THE MOLECULES REVEALED BY OUR DISCOVERY EFFORTS, WE EXPECT THE OUTCOMES OF THESE STUDIES WILL BROADLY IMPACT THE DEVELOPMENT OF STRATEGIES TO IMPROVE THE QUALITY OF STEM CELL DERIVATIVES TO PROMOTE THEIR UTILITY FOR DRUG TESTING, DISEASE MODELING, AND THERAPEUTIC APPLICATIONS, INFORM THE DEVELOPMENT OF CELL-TYPE DIRECTED PAYLOAD DELIVERY SYSTEMS AND DRUGS THAT AVOID CARDIOTOXIC EFFECTS, AND YIELD NEW STRATEGIES TO ASSESS AND TREAT ADVANCED HEART FAILURE.

MECHANISMS OF HEMOGLOBIN ADAPTATION TO HYPOXIA IN HIGH-ALTITUDE RODENTS

2023 NEBRASKA CONSOLIDATED PAYMENT GRANT

AREA HEALTH EDUCATION CENTERS POINT OF SERVICE MAINTENANCE AND ENHANCEMENT

CANCER RESEARCH INTERNATIONAL TRAINING AND INTERVENTION CONSORTIUM (CRITIC)

FOGARTY INTERNATIONAL TRAINING PROGRAM IN HIV- AND AIDS-ASSOCIATED MALIGNANCIES

EARLY DIAGNOSIS OF PANCREATIC CANCER

A PREDICTIVE MULTI-SCALE MODEL OF THE IMMUNE SYSTEM: AN INTEGRATED COMPUTATIONAL RESOURCE FOR INTERDISCIPLINARY APPLICATIONS.

MULTI-LASER-BEAM OPEN-ATMOSPHERE SURFACE COATING TECHNIQUES BASED ON PRECURSOR EXCITATION, PHOTODISSOCIATION AND CONTROLLED COOLING

** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** THE NORTH CENTRAL EXTENSION RISK MANAGEMENT EDUCATION CENTER (NCERMEC OR THE CENTER) WILL DELIVER RISK MANAGEMENT EDUCATION TO HELP AGRICULTURAL PRODUCERS MANAGE RISKS AND POSITION THEIR FARM OR RANCH FOR FUTURE GROWTH AND SUCCESS. THE CENTER, LOCATED AT THE UNIVERSITY OF NEBRASKA-LINCOLN, WILL IDENTIFY AND ASSESS PRODUCER RISK MANAGEMENT EDUCATION NEEDS AND EMERGING ISSUES THROUGH EFFORTS WITH SEVERAL PRODUCER AND STAKEHOLDER GROUPS, INCLUDING SPECIAL EMPHASIS AND UNDERSERVED PRODUCER AUDIENCES. BUILDING ON THE NEEDS ASSESSMENT RESULTS, THE CENTER WILL IMPLEMENT AN ANNUAL COMPETITIVE GRANTS PROGRAM FOR BOTH EDUCATION AND EXPLORATORY PROJECTS THAT DELIVER OR LEAD TO PRODUCER-FOCUSED, RESULTS-BASED RISK MANAGEMENT EDUCATION. AN ADVISORY COUNCIL WILL WORK WITH THE CENTER TO OVERSEE THE NEEDS ASSESSMENT AND PROGRAMMING EFFORTS AND TO IMPLEMENT THE GRANTS PROGRAM, INCLUDING REVIEW OF PROPOSALS IN ACCORDANCE WITH THE EXTENSION RISK MANAGEMENT EDUCATION (ERME) OPERATIONAL GUIDELINES. THE CENTER WILL HELP BUILD CAPACITY FOR RISK MANAGEMENT EDUCATION THROUGH TRAINING FOR EDUCATORS, APPLICANTS, AND GRANT RECIPIENTS AND WILL WORK WITH OTHER ERME PARTNERS TO DELIVER NATIONAL PROGRAMMING AND ADDRESS EMERGING ISSUES AS APPROPRIATE. THE CENTER WILL IMPLEMENT A COMPREHENSIVE COMMUNICATIONS PLAN TO ADMINISTER THE REGIONAL COMPETITIVE GRANTS PROGRAM, DOCUMENT RESULTS, PROMOTE THE ERME PROGRAM, AND MAINTAIN A STRONG NATIONAL LINKAGE WITH OTHER ERME PARTNERS. THE CENTER&#39;S OVERALL EFFORTS WILL ADDRESS PRODUCER NEEDS, INCREASE THE CAPACITY OF PRODUCERS TO ADOPT IMPROVED RISK MANAGEMENT PRACTICES AND DECISION-MAKING, AND HELP SUPPORT FINANCIALLY SUSTAINABLE, COMPETITIVE, AND PROSPEROUS AGRICULTURAL PRODUCTION OPERATIONS AND SYSTEMS.

REDOX BIOLOGY CENTER

THE UNIVERSITY OF NEBRASKA IS HEREBY AWARDED $1,349,707 TO ADMINISTER FOUR INSTITUTES FOR APPROXIMATELY 88 UNDERGRADUATE STUDENTS OR RECENTLY GRADUATED YOUNG LEADERS ON THE THEME OF CIVIC ENGAGEMENT.

CARDIAC SYMPATHETIC AFFERENT DENERVATION AND REMODELING IN HEART FAILURE

A COOPERATIVE AGREEMENT TO RESEARCH AND DEVELOP HIGH-SENSITIVITY

PANCREATIC TUMOR MICRO-ENVIRONMENT NETWORK

THE RECIPIENT SHALL UNDERTAKE ACTIVITIES RELATED TO THE TRANSFER OF SORGHUM AND MILLET PRODUCTION, PROCESSING AND MARKETING TECHNOLOGIES IN MALI.

GROWING NEBRASKA S FUTURE STEM WORKFORCE IS A HIGH PRIORITY FOR THE NASA NEBRASKA SPACE GRANT (NASA NEBRASKA). THROUGH STRATEGIC INVESTMENTS TARGETED TOWARD THE GENERAL PUBLIC K-12 HIGHER EDUCATION AND RESEARCH INFRASTRUCTURE.

THE NORTH CENTRAL EXTENSION RISK MANAGEMENT EDUCATION CENTER (NCERMEC) ADDRESSES THE VOLATILITY AND UNCERTAINTY THAT PRODUCERS FACE IN AGRICULTURE, THE EVOLVING FARM POLICY ENVIRONMENT THAT INCREASINGLY EMPHASIZES RISK MANAGEMENT, AND THE LEGISLATIVE MANDATE TO PROVIDE RISK MANAGEMENT EDUCATION TO AGRICULTURAL PRODUCERS. THE NCERMEC, LOCATED AT THE UNIVERSITY OF NEBRASKA-LINCOLN, WILL IDENTIFY AND ASSESS EDUCATIONAL NEEDS AND EMERGING ISSUES THROUGH EFFORTS WITH SEVERAL GROUPS, INCLUDING THE ADVISORY COUNCIL, STAKEHOLDER LISTENING GROUPS, THE NORTH CENTRAL FARM MANAGEMENT EXTENSION COMMITTEE, AND PROFESSIONAL CONTACTS AND NETWORKS. THE NCERMEC WILL BUILD ON THE NEEDS ASSESSMENT RESULTS TO IMPLEMENT AND DELIVER AN ANNUAL COMPETITIVE GRANTS PROGRAM AND RELEVANT EMERGING ISSUES PROGRAMMING AS APPROPRIATE. THE ADVISORY COUNCIL IS A KEY PART OF THE NCERMEC EFFORT AND WILL REVIEW, EVALUATE, AND SELECT PROPOSALS FOR COMPETITIVE FUNDING IN ACCORDANCE WITH THE EXTENSION RISK MANAGEMENT EDUCATION (ERME) OPERATIONAL GUIDELINES. THE NCERMEC WILL CONDUCT TRAINING FOR APPLICANTS AND GRANT RECIPIENTS TO IMPROVE PROJECT PROPOSALS AND EDUCATIONAL PROGRAMS AND WILL EMPHASIZE STRONG PROJECT RESULTS AND EVALUATION OF LONG-TERM PROGRAM IMPACTS. THE NCERMEC WILL ALSO ESTABLISH AN EFFECTIVE REPORTING, EVALUATION, AND COMMUNICATION STRATEGY THAT UPHOLDS THE INTEGRITY OF THE COMPETITIVE GRANTS PROGRAM AND DOCUMENTS AND COMMUNICATES THE IMPACT OF RISK MANAGEMENT EDUCATION TO ERME STAKEHOLDERS AND THE GENERAL PUBLIC. PROPOSED EFFORTS AND MEASURABLE OBJECTIVES FOR EACH PART WILL DEMONSTRATE THE CENTER&#39;S SUCCESS IN DELIVERING AGRICULTURAL RISK MANAGEMENT EDUCATION THAT DIRECTLY HELPS PRODUCERS ENHANCE THEIR PROFITABILITY AND VIABILITY AND IN TURN, MEET THE USDA AND AGENCY GOALS OF INCREASED RURAL PROSPERITY, RESOURCE STEWARDSHIP, AND FOOD SECURITY.

FFY 2016 SMITH LEVER 3BC

MULTI-ENERGY PROCESSING FOR NOVEL COATING TECHNOLOGIES

FY 2015 SMITH LEVER 3BC

THE MOLECULAR BIOLOGY OF NEUROSURGERY SYSTEMS

THIS EDA INVESTMENT SUPPORTS THE HEARTLAND ROBOTICS CLUSTER, LED BY THE INVEST NEBRASKA CORPORATION, WITH STRENGTHENING AGRICULTURAL TECHNOLOGY IN NEBRASKA BY ACCELERATING NEBRASKA'S LEADERSHIP IN THE AGRICULTURAL INDUSTRY THROUGH ROBOTIC TECHNOLOGIES AND ADVANCED MANUFACTURING AUTOMATION WHILE ALSO REVITALIZING THE REGION'S RURAL LABOR FORCE AND STRENGTHENING THE NATION'S FOOD SUPPLY CHAIN. THE PROJECTS FUNDED AS PART OF THIS AWARD INCLUDE EXPANSION OF THE NEBRASKA INNOVATION STUDIO IN ROBOTICS-SPECIFIC PROGRAMMING AND PROTOTYPING EQUIPMENT, CREATING AN ENVIRONMENT FOR INNOVATORS FROM ACROSS THE STATE AND FROM A VARIETY OF DEMOGRAPHICS TO DEVELOP AUTOMATION AND ROBOTIC SOLUTIONS. THE COALITION ALSO WILL IMPLEMENT SEVEN OTHER PROJECTS, INCLUDING ROBOTICS CURRICULUM DEVELOPMENT; WORKFORCE OUTREACH TO PROVIDE RURAL AREAS WITH OPPORTUNITIES TO WORK WITH CUTTING EDGE TECHNOLOGY; TECHNOLOGY COMMERCIALIZATION EFFORTS IN PARTNERSHIP WITH PRIVATE INDUSTRY; AND MANUFACTURING DEMONSTRATION SPACES TO DE-RISK ADOPTION OF NEW TECHNOLOGIES. ONCE IMPLEMENTED, THE INVESTMENT WILL HELP DEVELOP AND STRENGTHEN REGIONAL INDUSTRY CLUSTERS - ALL WHILE EMBRACING ECONOMIC EQUITY, CREATING GOOD-PAYING JOBS, AND ENHANCING U.S. COMPETITIVENESS GLOBALLY.

MECHANISMS OF CARDIAC SYMPATHETIC HYPERACTIVITY IN CHRONIC HEART FAILURE

NEBRASKA PEDIATRIC CLINICAL TRIAL UNIT

CANCER BIOLOGY TRAINING PROGRAM

NEBRASKA CONSOLIDATED PAYMENT GRANT

MECHANISTIC STUDIES OF STALLED DNA REPLICATION FORK RESCUE

TAS::573600::TAS "SAFEGUARDING END-USER MILITARY SOFTWARE"

RII TRACK-2 FEC: RESILIENCE INFORMATICS FOR THE CONVERGENCE OF CRITICAL CAPACITIES TO ADDRESS REGIONAL-SCALE ENVIRONMENTAL CHANGE

NURSE EDUCATION PRACTICE QUALITY AND RETENTION: CLINICAL FACULTY AND PRECEPTOR ACADEMY - UNMC COLLEGE OF NURSING 985330 NE MEDICAL CENTER, OMAHA, NE 68198-5330 DR. HEIDI KEELER, PHD, RN, P:402-559-6412 E:HKEELER@UNMC.EDU W: HTTPS://WWW.UNMC.EDU/CNE/ ABSTRACT: THE UNIVERSITY OF NEBRASKA MEDICAL CENTER COLLEGE OF NURSING (UNMC CON) IS ENGAGED IN A MULTI-YEAR EFFORT BASED UPON THE CONCEPT OF MODERN APPRENTICESHIP USING INNOVATIVE, MOBILE TECHNOLOGY AND DESIGN TO CREATE AN ACADEMY CONSISTING OF ACADEMIC-CLINICAL-COMMUNITY PARTNERSHIPS AND AN ADVOCACY HUB. THIS WILL UNDERPIN THE DEVELOPMENT AND IMPLEMENTATION OF A FORMAL NURSE CLINICAL EDUCATION TRAINING CURRICULUM CAPITALIZING ON MICRO-LEARNING SESSIONS AND JUST IN TIME TRAINING FOR CLINICAL NURSING FACULTY AND PRECEPTORS. TO DO THIS, SEVERAL ACTIVITIES AND DELIVERABLES ARE PLANNED. A COMPREHENSIVE NEEDS ASSESSMENT TO IDENTIFY THE UNIQUE CLINICAL PRECEPTOR LANDSCAPE IN THE REGION, TO INCLUDE MOTIVATING FACTORS AND BARRIERS, THAT WILL INFORM THE VISION AND CREATION OF STANDARDIZED CURRICULUM, RECRUITMENT AND RETENTION STRATEGIES, AND SUPPORTIVE INFRASTRUCTURE FOR CLINICAL PRECEPTING WILL BE CONDUCTED. THEN, USING THIS INFORMATION, A PRECEPTOR ACADEMY WILL BE CREATED TO TRAIN AND SUPPORT CLINICAL FACULTY/PRECEPTORS USING INNOVATIVE MOBILE TECHNOLOGY, DESIGN, AND APPROACH WHICH IS BOTH UNIQUE TO THE LOCAL NEED NURSES AND AMENABLE TO SCALING TO A REGIONAL AND NATIONAL LEVEL. THIS WILL ALLOW FOR NURSES ACROSS THE REGION TO CUSTOMIZE WHAT THEY NEED TO BE BEST PREPARED IN THEIR LOCAL AREA AND PRACTICE. NEXT, RELATIONSHIPS WITH EXISTING AND NEW ACADEMIC-CLINICAL-COMMUNITY PARTNERS WILL BE ENHANCED TO CREATE NEW CLINICAL FACULTY OPPORTUNITIES, ASSESS CLINICAL PRECEPTOR NEEDS, ADDRESS BARRIERS TO RECRUITMENT AND RETENTION, CONTRIBUTE TO AND ENHANCE COLLECTIVE EXPERTISE, AND HARNESS COMMUNICATION NETWORKS TO SHARE PRECEPTOR ACADEMY OPPORTUNITIES AND RESOURCES. TO OPTIMIZE THE SUCCESS OF BOTH NEW AND CURRENT CLINICAL FACULTY, NEW AND EXISTING RELATIONSHIPS WILL BE LEVERAGED TO IMPLEMENT NEW SUP PORT SERVICES TO INCLUDE PROMOTION OF RESILIENCY AND WELL-BEING AS WELL AS PREVENTION OF BURNOUT. TO ASSURE THAT THE ARTICULATED EFFORTS ARE INCREASING THE NURSING WORKFORCE BY RECRUITING, TRAINING, AND PRODUCING SKILLED QUALIFIED CLINICAL NURSING FACULTY AND NURSING PRECEPTORS, A COMPREHENSIVE EVALUATION PLAN WILL BE DEVELOPED AND IMPLEMENTED. THESE AIMS WILL BE ACHIEVED THROUGH THE CLOSE COLLABORATION OF KEY STAKEHOLDERS, INITIALLY ACROSS THE STATE IN ITS PILOT PHASE, AND THEN ACROSS HRSA REGION 7, WHICH CONSISTS OF NEBRASKA, IOWA, KANSAS, AND MISSOURI. THE FUNDS AWARDED WILL BE USED TO RESERVE TIME FOR STAKEHOLDERS TO DETERMINE HOW TO ADAPT NATIONAL BEST PRACTICES INTO THE UNIQUE ENVIRONMENT OF THE REGION. THIS WILL INCLUDE THE CREATION OF A PRECEPTOR ACADEMY STANDARDIZED CURRICULUM THAT WILL NOT ONLY PRODUCE JUST IN TIME TRAININGS FOR PRECEPTORS, BUT ALSO FOCUS ON A MOBILE DELIVERY SYSTEM MOST USED BY PRECEPTORS IN PRACTICE. THIS WILL BE OVERSEEN BY A TEAM OF FACULTY, EXPERT STAFF, NEWLY CREATED CLINICAL NURSE LIAISON, CLINICAL PARTNERS, AND COMMUNITY COLLABORATORS. IN ADDITION, THE STAKEHOLDER WORKGROUP WILL USE THE FUNDING TO DETERMINE ADDITIONAL WAYS TO REDUCE BARRIERS TO PRECEPTING, SUCH AS TIME, RENUMERATION, STRESS AND BURNOUT, AND LACK OF CONNECTION TO PRECEPTOR PEERS OR SUPPORT SYSTEMS. THIS AWARD, REQUESTED AS A RURAL PREFERENCE IN THE AMOUNT OF 1M PER YEAR OVER 4 YEARS, IS DEDICATED TO BUILDING CLINICAL PRECEPTOR CAPACITY IN REGION 7, AND WILL CREATE A FIRM FOUNDATION FOR COMMUNITY-ACADEMIC-CLINICAL PARTNERSHIPS WELL POSITIONED TO ADDRESS CURRENT AND FUTURE NURSING WORKFORCE PROBLEMS.

THE ROLE OF MACROPHAGE-DERIVED MMPS IN LV REMODELING

BATTLEFIELD AIRWAY MANAGEMENT FOR WOUNDED WARRIORS: SAFE AIRWAY ACCESS IN COMBAT, BATTLEFIELD ANDROID TELEMEDICINE SYSTEM

GERIATRICS WORKFORCE ENHANCEMENT PROGRAM

ROBOTIC TELESURGERY RESEARCH

THE COMBINATORIAL EFFECTS OF OPIATES AND THE EMERGING PROMOTER-VARIANT STRAINS OF HIV-1 SUBTYPE C ON HIV NEUROPATHOGENSIS AND LATENCY

GOALS&OBJECTIVESNEBRASKA IS EVOLVING. WHILE AGRICULTURE AND RELATED INDUSTRIES STILL PROVIDE A SOLID FOUNDATION FOR THE STATE'S ECONOMY THERE IS STRONG EVIDENCE OF TECHNOLOGICAL INNOVATIVE AND ENTREPRENEURIAL EFFORTS IN THE FIELDS OF SCIENCE TECHNOLOGY ENGINEERING AND MATHEMATICS (STEM). LEADING THE CHARGE IN THESE AREAS ARE THE STATE'S COLLEGES AND UNIVERSITIES WHICH PROVIDE SUPPORTIVE INFRASTRUCTURES AND STIMULATING ENVIRONMENTS FOR KNOWLEDGE DEVELOPMENT. THE NEBRASKA SPACE GRANT CONSORTIUM CONTINUES TO PLAY AN IMPORTANT ROLE IN THE ONGOING TRANSFORMATION OF THE STATE'S INSTITUTIONS OF HIGHER LEARNING BY EFFECTIVELY AND EFFICIENTLY LEVERAGING NASA RESOURCES TO MEET THE NEEDS OF THE STATE AND THE NATION. THE NSGC FOCUSES ITS EFFORTS ON IMPROVING TEACHING AND LEARNING IN THE STEM DISCIPLINES WHICH IN TURN INCREASES THE RECRUITMENT AND RETENTION OF STUDENTS IN STEM FIELDS AND ULTIMATELY STEM CAREERS.

CMV RESPONSES IN AUTOANTIBODY POSITIVE SUBJECTS ADVOCATE ANTIVIRAL TREATMENTS FOR PREVENTION OF T1D

ROLE OF HIV ENV GLYCOSYLATION IN MUCOSAL TRANSMISSION

RESEARCH IAW INDEPENDENT VERIFICATION AND VALIDATION FOR BIOLOGICAL AGENTS FOR THE DARPA PERSONALIZED PROTECTIVE BIOSYSTEM (PPB)

A BEDSIDE-TO-BENCH APPROACH TO PANDEMIC PREPAREDNESS - THE CLINICAL CAPABILITIES OF THE UNIVERSITY OF NEBRASKA MEDICAL CENTER (UNMC) AND ITS CLINICAL PARTNER, NEBRASKA MEDICINE (NM), PLAYED VITAL ROLES IN THE TREATMENT OF U.S. CITIZENS INFECTED WITH EBOLA IN 2014 AND THE EARLY RESPONSE TO THE COVID-19 PANDEMIC. WHILE THE PRESENCE OF THE NATIONAL QUARANTINE UNIT (NQU) AND THE NEBRASKA BIOCONTAINMENT UNIT (NBU) ON CAMPUS PROVIDED UNMC RESEARCHERS WITH SOME OF THE EARLIEST ACCESS TO INDIVIDUALS EXPOSED TO INFECTIOUS AGENTS (IN THE NQU), AS WELL AS THOSE WHO BEGIN TO DEVELOP DISEASE (IN THE NBU), WE RECOGNIZED A KEY GAP IN OUR CAPABILITIES IS THE LACK OF MODERN TECHNOLOGIES WITHIN OUR HIGH- CONTAINMENT SPACES REQUIRED TO GAIN GREATER INSIGHTS INTO THE PATHOGENIC MECHANISMS UTILIZED BY NEW AND EMERGING PATHOGENS. THEREFORE, THE OVERALL GOAL OF THIS PROPOSED PROJECT IS TO MODERNIZE OUR HIGH-CONTAINMENT RESEARCH LABORATORIES TO MAXIMIZE THEIR RESEARCH POTENTIAL AND TO LEVERAGE OUR CLINICAL EXPERTISE TO FOSTER RESEARCH ON VACCINE AND THERAPEUTIC DEVELOPMENT. THIS WILL BE ACHIEVED IN TWO WAYS: FIRST, WE WILL IMPROVE OUR BIOCONTAINMENT INFRASTRUCTURE WITHIN KEY BIOCONTAINMENT RESEARCH FACILITIES IN A WAY THAT INCREASES OUR CAPACITY TO CONDUCT RESEARCH ON HIGH-CONSEQUENCE PATHOGENS, MAXIMIZES SYNERGY BETWEEN THE VARIOUS BIOCONTAINMENT LABORATORIES, AND INCREASES BIOSECURITY. SECOND, WE WILL INVEST IN THE MODERN TECHNOLOGIES NEEDED IN OUR BSL-3 AND ABSL-3 LABORATORIES TO CONDUCT CUTTING-EDGE STUDIES ON NEW AND EMERGING PATHOGENS AND TO ADDRESS CRITICAL QUESTIONS RELATED TO DISEASE PATHOGENESIS. UPON COMPLETION, THESE IMPROVEMENTS WILL FOSTER MUCH GREATER SYNERGY BETWEEN THE CLINICAL AND RESEARCH ARMS OF UNMC AND NM, LEVERAGING EARLY ACCESS TO CLINICAL DATA/SAMPLES TO STREAMLINE RESEARCH INTO DISEASE PATHOGENESIS, AND TO ACCELERATE THE DEVELOPMENT OF NEW VACCINES AND THERAPEUTICS DURING FUTURE PANDEMICS.

CONSOLIDATED PROGRAM GRANTS TO STATE FORESTRY AGENCIES ARE AWARDED WITH ANNUALLY APPROPRIATED FUNDS TO STATE FORESTRY AGENCIES TO FUND MULTIPLE PROGRAMS AUTHORIZED IN THE COOPERATIVE FORESTRY ASSISTANCE ACT. MANY OF THESE PROGRAMS PROVIDE DIRECT SUPPORT TO NON-INDUSTRIAL PRIVATE FOREST LANDOWNERS. ALSO INCLUDED ARE STATE FIRE ASSISTANCE AND VOLUNTEER FIRE ASSISTANCE FUNDS.

ADVANCE INSTITUTIONAL TRANSFORMATION AWARD: AN INSTITUTION-WIDE COLLABORATION TO HIRING, RETAINING, AND PROMOTING WOMEN STEM FACULTY AT THE UNIVERSI

EFFICACY OF VIRTUAL PROFESSIONAL DEVELOPMENT IN RURAL SCHOOLS TO ENHANCE TEACHER-PARENT PARTNERSHIPS FOR STUDENTS WITH BEHAVIORAL CHALLENGES

CGMP RECOMBINANT FIX FOR IV & ORAL HEMOPHILIA B THERAPY

THE BRAIN AS A SIV RESERVOIR UNDER SUPPRESSIVE CART POTENTIATION BY DRUGS OF ABUSE

ROLE OF PATTERN RECOGNITION RECEPTORS IN ORGANIC DUST-INDUCED AIRWAY INFLAMMATION

THE UNIVERSITY OF NEBRASKA AT OMAHA IS HEREBY AWARDED $1,299,993 TO SUPPORT THE FY 2018 YSEALI ACADEMIC FELLOWSHIP ON CIVIC ENGAGEMENT

THE LYMPHOID TISSUE PHARMACOLOGY OF ANTIRETROVIRAL DRUGS

UNDERSTANDING TREHALOSE SYNTHESIS AND UTILIZATION IN MYCOBACTERIA

2022 NEBRASKA CONSOLIDATED PAYMENT GRANT - COOPERATIVE FORESTRY AND STATE AND VOLUNTEER FIRE ASSISTANCE

EDUCATING UNDERGRADUATE STUDENTS FOR STEM CAREER OPPORTUNITIES IN NEBRASKA: NETWORKS, EXPERIENTIAL-LEARNING, & COMPUTATIONAL THINKING

CONSEQUENCES OF IN VIVO NEOCORTICAL GAD67 DOWNREGULATION

EXECUTIVE FUNCTION DEVELOPMENT IN PRESCHOOL CHILDREN

"(CONGRESSIONAL) BATTLESPACE ACTIONCENTERS", UNDATED

MOLECULAR SIGNATURES TO IMPROVE DIAGNOSIS AND OUTCOME PR

COMBINED MOLECULAR EXCISION THERAPY (CMET) FOR ELIMINATING HIV-1

LASER ART FOR PREP - ABSTRACT THIS PROJECT CONTAINS A HIGHLY COLLABORATIVE INVESTIGATIVE TEAM WITH INTERDISCIPLINARY EXPERTISE WITH SIGNIFICANT POTENTIAL IMPACT FOR HIV/AIDS PREVENTION. THE PROPOSAL INCLUDES PHARMACOLOGIC, VIROLOGIC, ANIMAL AND PRODUCT DEVELOPMENT STUDIES DESIGNED TO HALT DISEASE TRANSMISSION THROUGH NOVEL LONG-ACTING (LA) ANTIRETROVIRALS. THESE ARE NAMED LA SLOW EFFECTIVE RELEASE ANTIRETROVIRAL THERAPIES (LASER ART) DESIGNED TO FACILITATE HIV-1 PREVENTION BY INTENSE BENCH TO THE CLINIC TRANSLATIONAL STUDIES. INNOVATIVE INTERDISCIPLINARY APPROACHES CONTAIN A DETAILED RESEARCH PLAN, EXTENSIVE PRELIMINARY AND BROADLY PUBLISHED SUPPORTIVE DATA. CREATIVITY AND INNOVATIVENESS ARE OFFERED PLACED AT HIGHER RISK THAN A CONVENTIONAL RESEARCH PROJECT. THE WORK BUILDS ON THE DEVELOPMENT OF PARENTERAL NANOFORMULATIONS OF CHEMICALLY MODIFIED ANTIRETROVIRAL DRUGS DESIGNED TO IMPROVE ADHERENCE. THE DRUGS ARE CURRENTLY OFFERED ONCE/DAY IN PILL FORM BUT WILL BE CONVERTED TO UP TO ONCE A YEAR ADMINISTRATION. SUPPORT FROM EXPERT PHARMACOLOGISTS AND PHARMACEUTICAL SCIENTISTS WITH UNIVERSITY RESEARCHERS ARE OPERATIVE. THE DRUGS INCLUDE DOLUTEGRAVIR (DTG), EMTRICITABINE (FTC) AND TENOFOVIR (TFV) CREATED TO EXTEND THEIR APPARENT DRUG HALF-LIFE, EFFICACY AND ABILITIES TO TARGET VIRAL RESERVOIRS. THEY ARE, IN MEASURE, DTG AND FTC AND TFV PRODRUG + NUCLEOTIDE (PROTIDES) DESIGNATED “N” FOR NANOFORMULATION, “M” FOR ESTERIFICATION AND “P” FOR PROTIDES. THE CREATED NPFTC AND NPTFV AND NM2DTG DEMONSTRATE SUSTAINED PLASMA AND TISSUE DRUG CONCENTRATIONS OF > 90% INHIBITORY CONCENTRATION FROM MONTHS TO A YEAR. BASED ON ENCOURAGING RESULTS, WE SEEK FUNDS TO FACILITATE LARGE SCALE DEVELOPMENT THAT WOULD FACILITATE FUTURE HUMAN STUDIES. THE FINAL FORMULATIONS WOULD BE CHARACTERIZED BY SUSTAINED PRODRUG HYDROLYSIS WITH REDUCED INJECTION VOLUMES. THE PATHWAY FORWARD FOLLOWS ESTABLISHED PARTNERSHIP WITH THE CLINTON HEALTH ACCESS INITIATIVE AND OVERSIGHT BY VIIV HEALTHCARE AND GILEAD SCIENCES. THE OVERARCHING GOAL IS SAFETY, REPRODUCIBILITY AND “SCALE-UP” THAT FOLLOWS US FOOD AND DRUG ADMINISTRATION-APPROVED CURRENT GOOD MANUFACTURING PRACTICES (CGMP). THE SPECIFIC AIMS ARE EACH SUPPORTED BY EXTENSIVE PUBLISHED DATA SETS FORGED THROUGH THE MULTIDISCIPLINARY RESEARCH. CREATION AND CHARACTERIZATION FOCUS ON PRODRUG FORMULATIONS, TOXICOLOGY, AND PHARMACOKINETICS PROFILES FOLLOW A SAFE DEVELOPMENTAL ACTION PLAN. THE WORK IS FACILITATED BY A FULLY OPERATIONAL CGMP FACILITY AND RHESUS MACAQUE VALIDATIONS. THE LEAD FORMULATION WILL BE DEVELOPED WITH OUR CHAI PARTNERS. WE POSIT THAT THE CREATION OF LASER ART DTG OR FTC AND TFV WILL HAVE A PROFOUND IMPACT ON HIV PREVENTION.

NNCI: NEBRASKA NANOSCALE FACILITY (NNF)

SPECIAL EDUCATION RESEARCH PROGRAM

NNCI: NEBRASKA NANOSCALE FACILITY (NNF)

HIV-1DETECTIONANDELIMINATIONFROM CNS MONONUCLEAR PHAGOCYTES - ABSTRACT MONONUCLEAR PHAGOCYTES (MP; MONOCYTES, MACROPHAGES, DENDRITIC CELLS. AND MICROGLIA) SERVE AS HUMAN IMMUNODEFICIENCY VIRUS TYPE ONE (HIV-1) RESERVOIRS, SITES OF VIRAL PERSISTENCE AND LATENCY, AND INDUCERS OF END- ORGAN DISEASE. ALL ARE COMMONLY LINKED TO HIV-1 PATHOBIOLOGY. HOWEVER, THE KEY RELEVANCE OF THE MP VIRAL RESERVOIR RESTS IN THE CENTRAL NERVOUS SYSTEM (CNS) OF THOSE PEOPLE LIVING WITH HIV (PLWH). IN THOSE PLWH AND RECEIVING ANTIRETROVIRAL THERAPY (ART), THE EVIDENCE FOR THE SIZE, SCOPE, AND DISEASE RELEVANCE OF THE CNS VIRAL RESERVOIR REMAINS UNDER APPRECIATED. THE DISCORDANCE BETWEEN LABORATORY MP INFECTION AND TISSUE PERSISTENCE IN AN INFECTED HUMAN HOST IS ALSO NOT YET KNOWN. MP CAN HAVE AN EXTENDED LIFE SPAN AND POSSESS SELF-RENEWING POTENTIAL, AND AS SUCH, ARE LIKELY MORE RELEVANT IN DISEASE THAN CURRENTLY APPRECIATED. EVALUATION OF THE SIGNIFICANCE OF MPS, IN GENERAL, AND THE MICROGLIA SPECIFICALLY WILL HELP DEFINE THE IMPORTANCE OF MPS DURING NATURAL INFECTION. FOR THE CNS SPECIFICALLY, HIV-1 ENTERS THE BRAIN SOON AFTER INFECTION AND REPLICATES IN PERIVASCULAR MACROPHAGES AND MGL ALONG WITH LIMITED NUMBERS OF ASTROCYTES. VIRAL SET POINT AND TIMING OF ART INITIATION DETERMINES THE LATENT RESERVOIR SIZE; EACH AFFECTS THE EFFICIENCY OF ANY ERADICATION STRATEGY. KNOWLEDGE OF THE VIRAL DYNAMICS, CNS VIRAL INVASION, SUSCEPTIBILITY TO MP INFECTION, AND COMPOSITION OF CNS HIV RESERVOIR WILL FACILITATE EFFECTIVE THERAPEUTIC INTERVENTIONS. TO EACH OF THESE ENDS, WE WILL EMPLOY NOVEL TECHNIQUES TO STUDY THE MP HIV-1 RESERVOIR IN LABORATORY SYSTEMS AND IN A NEWLY DEVELOPED HUMAN MICROGLIAL MOUSE MODEL OF HUMAN DISEASE. WE WILL USE BASIC AND APPLIED MP BIOLOGY, THERANOSTICS, NOVEL ART NANOFORMULATIONS, MOLECULAR AND CELLULAR BIOLOGY, AND OUR UNIQUE ANIMAL MODEL TO STUDY THE MEANS TO ELIMINATE VIRAL INFECTION AT THE SUBCELLULAR, CELLULAR, AND TISSUE LEVEL WITH NEWLY DESIGNED AND NOVEL THERAPEUTIC METHODS THAT INCLUDE GENE THERAPY STRATEGIES. OUR AIMS ARE TO DETERMINE THE EFFICIENCY OF VIRAL SUPPRESSION BY NATIVE AND NANOFORMULATED ART (AT SUBCELLULAR LEVEL), ASSESS THE BREADTH OF THE CNS VIRAL RESERVOIRS AGAINST VIRAL SET POINTS (DEFINED BY THE INITIATION OF ART), AND TO EXPLORE COMBINATION STRATEGIES FOR HIV-1 ELIMINATION IN A NEW DEVELOPED HUMANIZED MICROGLIAL MOUSE.

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