University Research Foundation Inc

FOR 30 YEARS SAN JOSE STATE UNIVERSITY (SJSU) HAS PARTNERED WITH NASA AMES RESEARCH CENTER (ARC) ON COLLABORATIVE HUMAN SYSTEMS INTEGRATION RESEARCH (HSIR) THAT HAS MADE AIR AND SPACE TRAVEL MORE SAFE EFFICIENT AND RELIABLE. WE NOW PROPOSE A FIVE-YEAR RESEARCH PLAN TO BUILD UPON OUR COLLABORATIVE WORK IN THE HUMAN SYSTEMS INTEGRATION DIVISION (CODE TH) OTHER ARC DIVISIONS AND THE US MILITARY UNDER COOPERATIVE AGREEMENT NNX12AB08A. THE RESEARCH WE PROPOSE FULFILLS THE TECHNICAL AREAS PREVIOUSLY IDENTIFIED IN NASA SOLICITATION NNA11364623A THAT REMAIN RELEVANT TO THE MISSION AND STRATEGIC GOALS OF NASA AND OTHER GOVERNMENTAL ORGANIZATIONS (E.G. FAA US ARMY). THESE AREAS ARE: (1) HUMAN-AUTOMATION INTERACTION (2) HUMAN-COMPUTER INTERACTION AND (3) INDIVIDUAL- AND TEAM-PERFORMANCE FACTORS. THIS PROPOSAL WILL ALSO EXPAND UPON PREVIOUS RESEARCH BY INCORPORATING NEW EMPHASES THAT HAVE EMERGED SINCE OUR LAST PROPOSAL. THIS PROPOSAL ENCOMPASSES THE EXISTING SJSU/ARC LABORATORY ORGANIZATION AND TECHNICAL COMPETENCIES BASED ON OUR KNOWLEDGE OF NASA S PROCESSES ACQUIRED DURING OUR LONG PARTNERSHIP. WE ANTICIPATE SIGNIFICANT BENEFITS FOR NASA FROM MAINTAINING THAT PARTNERSHIP INCLUDING: (1) AN EXISTING STRONG RESEARCH AND MANAGEMENT INFRASTRUCTURE THAT WILL REMAIN ON-SITE THROUGHOUT THE AWARD PERIOD PROVIDING TIMELY AGILE AND ADAPTIVE RESPONSES TO NASAS NEEDS AND PRIORITIES; (2) LONG-TERM CONTINUITY FOR RESEARCH ACTIVITIES; (3) SHARED GOALS AND SHARED INSTITUTIONAL KNOWLEDGE; (4) KNOWN AND RESPECTED PERSONNEL WHO HAVE ESTABLISHED PRODUCTIVE WORKING RELATIONSHIPS WITH NASA SCIENTISTS AND MANAGEMENT; (5) ACADEMIC STUDENT AND PUBLIC OUTREACH PROGRAMS CREATED TO ENHANCE NASA PROJECTS DEVELOP RELEVANT WORKFORCE SKILLS AND MEET NASA S MISSION AND STRATEGIC GOALS; (6) AN EXPERIENCED MANAGEMENT TEAM WITH A STRONG FOCUS ON SUSTAINED COLLABORATION; (7) A SUPPORTIVE AND RESPONSIVE ORGANIZATION IN THE SAN JOSE STATE UNIVERSITY RESEARCH FOUNDATION (SJSURF); (8) PROVEN SUCCESSFUL PROJECT MODELS; AND (9) RESOURCE EFFICIENCIES THROUGH AVOIDANCE OF A TIME-CONSUMING AND COSTLY TRANSITION TO ANOTHER RESEARCH ORGANIZATION.

ANTICIPATED DRAMATIC INCREASES IN AIR TRAFFIC HAVE FUELED THE PLANNED CONVERSION TO THE NEXT GENERATION AIR TRANSPORTATION SYSTEM, WHICH REINVENTS AI

HUMAN SYSTEMS INTEGRATION: COLLABORATIVE HUMAN FACTORS RESEARCH TO IMPROVE THE SAFETY EFFICIENCY AND RELIABILITY OF NASAS AERONAUTICS AND SPACE MISSIONS: PHASE 2

BEING A FIVE YEAR COOPERATIVE AGREEMENT WITH A TECOF $24,000,000 AND INITIAL OBLIGATION OF $500,000

INVESTING IN INNOVATION - SCALE UP

THE SCIENCE OF DECISION MAKING: CONNECTING PEOPLE AND POLICY

TO PROVIDE SUPPORT FOR "FAMILY PLANNING AND REPRODUCTIVE HEALTH METHODS TO ADDRESS UNMET NEEDS"

PROTOTYPE STUDY OF A NEW CENTRAL DRIFT CHAMBER FOR CLEO II & INVESTIGATION OF THE T PARADOX USING CLEO II OUTSTANDING JUNIOR INVESTIGATOR PROGRAM.

THERAPEUTICS TARGETING FILOVIRAL INTERFERON-ANTAGONIST AND REPLICATION FUNCTIONS

CROSS-INSTITUTIONAL COLLABORATION AND REIMAGINING TOWARD EQUITY, ACCESS, AND TEACHER EFFECTIVENESS: EXPANDING AND SUSTAINING PROJECT CREATE

GEAR-UP

FROM QUARKS TO NUCLEI

FY 2009 TEACHER QUALITY PARTNERSHIPS GRANTS

SCIENCE ROOTS: GROWING STUDENT FUTURES THROUGH GENAI ENHANCED PROJECT-BASED LEARNING USING GREEN NINJA

NATIONAL CENTER FOR SPECIAL RESEARCH (NCSER)

NEW COE CA "DOD CENTER OF EXCELLENCE IN ADVANCED COMPUTING AND SOFTWARE (COE-ACS)"

EDUCATION RESEARCH AND DEVELOPMENT CENTERS

THIS UNSOLICITED COOPERATIVE AGREEMENT PROPOSAL SEEKS FUNDING FOR THREE YEARS TO CONDUCT COLLABORATIVE RESEARCH BETWEEN THE U.S. ARMY AVIATION DEVELOPMENT DIRECTORATE AT NASA AMES RESEARCH CENTER AND THE DEPARTMENT OF PSYCHOLOGY AT SAN JOSE ...

STRENGTHENING THE UNIVERSITY-DISTRICT-COMMUNITY PARTNERSHIP: COMPASSION, REFLECTION AND EQUITY FOR ATLANTA TEACHER EFFECTIVENESS (CREATE)

MODELING AND SIMULATION OF HUMAN PERFORMANCETHE PRESENT PROPOSAL REQUESTS AN 18-MONTH CONTINUATION

CENTER FOR BEHAVIORAL NEUROSCIENCE

MULTIVARIATE METHODS FOR IDENTIFYING MULTI-TASK/MULTIMODAL BRAIN IMAGING BIOMARKE

MECHANISMS OF EVASION OF THE INNATE AND ADAPTIVE IMMUNE RESPONSES TO FILOVIRUSES

FY 2009 TEACHER QUALITY PARTNERSHIPS GRANTS

FIRST IN THE WORLD - VALIDATION

STARVE AND KILL: ENGINEERED ANTIGENS TARGETING NUTRIENT ACQUISITION PATHWAYS ESSENTIAL FOR GONOCOCCAL INFECTION AND DISEASE

THE PRESENT UNSOLICITED PROPOSAL REQUESTS FUNDING OF A THREE-YEAR COOPERATIVE AGREEMENT BETWEEN THE ARMY AEROFLIGHTDYNAMICS DIRECTORATE (AFDD) AT THE

UNIVERSITY TRANSPORTATION CENTERS

ADVANCED GAS TURBINE SYSTEMS RESEARCH - HIGH EFFICIENCY ENGINES AND TURBINES (AGTSR-HEET)

FUTURE VERTICAL LIFT: COLLABORATIVE RESEARCH ON FLIGHT CONTROL AUTONOMOUS ROTORCRAFT AND HUMAN-SYSTEMS INTERFACE DESIGN: PHASE 2

THE PRIMARY PURPOSE OF THE PROPOSED PROGRAM IS TO TRANSFER FUNDS TO ACCOMPLISH A PUBLIC PURPOSE OF SUPPORT OR STIMULATION OF THE HIV PREVENTION PRODUCTS TARGETED FOR ADOLESCENT GIRLS AND YOUNG WOMEN IN LOW AND MIDDLE INCOME COUNTRIES.

MATHEMATICAL BIOSCIENCES INSTITUTE

NURTURES

THE OHIO STATE UNIVERSITY CENTER FOR CLINICAL AND TRANSLATIONAL SCIENCE (UL1)

CREW FACTORS AND TEAM PERFORMANCE PHASE IITHE PRESENT PROPOSAL REQUEST THE CONTINUATION OF FUNDING

CREATE (COLLABORATION AND REFLECTION TO ENHANCE ATLANTA TEACHER EFFECTIVENESS)

TAS::57 3600::TAS (MURI 09) FUNDAMENTAL MECHANISMS, PREDICTIVE MODELING, AND NOVEL AEROSPACE APPLICATIONS OF PLASMA ASSISTED COMBUSTION

CENTER OF EXCELLENCE: ENVIRONMENTAL HEALTH DISPARITIES CORE

IMPLEMENTATION GRANT: COMMUNITY-SOIL-AIR-WATER (CSAW): A MODEL COMMUNITY-BASED LEARNING ECOSYSTEM TO TRANSFORM GEOSCIENCES -THE COMMUNITY-SOIL-AIR-WATER (CSAW) LEARNING ECOSYSTEM WILL INTEGRATE JUSTICE, EQUITY, DIVERSITY, AND INCLUSION INTO THE PRACTICES OF COLLABORATING WITH COMMUNITIES IN GEOSCIENCES RESEARCH. TO EXPAND CAPACITY AND ACCOUNTABILITY IN SOCIO-ENVIRONMENTAL RESEARCH COLLABORATIONS BETWEEN GEOSCIENTISTS AND COMMUNITY PARTNERS, CSAW WILL BRING TOGETHER THREE ACADEMIC PARTNERS (GEORGIA STATE UNIVERSITY, A PREDOMINANTLY BLACK INSTITUTION, SPELMAN COLLEGE, A HISTORICALLY BLACK COLLEGE, AND EMORY UNIVERSITY) WITH TWO COMMUNITY ORGANIZATIONS: THE WEST ATLANTA WATERSHED ALLIANCE AND ECO-ACTION. THIS PROJECT WILL ADDRESS THE QUESTION: HOW CAN GEOSCIENTISTS LEARN FROM, CONTRIBUTE TO, AND FIND SOLUTIONS WITH COMMUNITIES FACING FUNDAMENTAL PROBLEMS RELATED TO EARTH SYSTEMS? CSAW WILL EXAMINE HOW A LEARNING ECOSYSTEM MODEL CENTERED IN COMMUNITY-ENGAGED, PLACE-BASED RESEARCH CAN INCREASE: (1) RECRUITMENT, RETENTION, AND TRAINING OF DIVERSE GEOSCIENTISTS; AND (2) CAPACITY FOR AND ACCOUNTABILITY WITHIN COLLABORATION BETWEEN GEOSCIENTISTS AND COMMUNITIES ADDRESSING SOCIO-ENVIRONMENTAL PROBLEMS. COHORTS OF FACULTY AND COMMUNITY ORGANIZERS ALONG WITH 12 POST-BACCALAUREATE (POSTBAC) SCHOLARS AND 15 MASTER?S STUDENTS WILL BE TRAINED IN BUILDING OUTREACH AND RESEARCH PROJECTS WITH COMMUNITY PARTNERS USING A FRAMEWORK OF SHARED VALUES OF EQUITY, TRANSPARENCY, AND ACCOUNTABILITY. THESE PROJECTS WILL ADDRESS CRITICAL NEEDS IN PLACE-BASED EARTH SYSTEMS RESEARCH INCLUDING SOIL LEAD AND OTHER HEAVY METAL CONTAMINATION AND RADON EXPOSURE; AIR POLLUTION, CLIMATE CHANGE, AND HEAT MAPPING; AND WATER POLLUTION, URBAN FLOODING, AND GREEN STORMWATER INFRASTRUCTURE. THE OVERALL GOALS AND OBJECTIVES OF THE PROJECT ARE TO BUILD A BRIDGE: 1) BUILD AND FORMALIZE THE CSAW LEARNING ECOSYSTEM WITH ALL COHORT MEMBERS TO SOLVE SOCIO-ENVIRONMENTAL CHALLENGES; 2) RECRUIT DIVERSE COHORTS OF POSTBACS AND MASTER?S STUDENTS AND TRAIN THEM IN PROFESSIONAL DEVELOPMENT, COMMUNITY ENGAGEMENT, AND NETWORKING, WITH A FOCUS ON CENTERING JUSTICE, EQUITY, AND INCLUSION; 3) IMPLEMENT TRAINING, PROGRAMMING, AND PEDAGOGY PROTOCOLS TO RECRUIT, MENTOR, AND SUPPORT DIVERSE STUDENTS, COMMUNITY COLLABORATORS, AND FACULTY IN THE GEOSCIENCES; 4) DEVELOP AN ASSET-BASED MODEL OF COLLABORATION WITH COMMUNITY-DRIVEN RESEARCH TO INCLUDE FORMAL TRAINING, ACCOUNTABILITY, AND ASSESSMENT FOR ENGAGEMENT PRACTICES AND OUTCOMES; AND 5) GROW A NETWORK, MATERIALS, AND PROTOTYPE TO EXPAND THE CSAW LEARNING ECOSYSTEM MODEL TO OTHER COMMUNITIES, UNIVERSITIES, AND INSTITUTIONS. CSAW PARTNERSHIPS WILL ADVANCE A BROAD RANGE OF SCHOLARSHIP ON SOCIO-ENVIRONMENTAL PROBLEMS AND THEIR SOLUTIONS, AND ON BEST PRACTICES FOR GEOSCIENTISTS IN COMMUNITY ENGAGEMENT, ACCOUNTABILITY, AND CO-PRODUCTION. CSAW WILL PROVIDE A WELL-EVALUATED AND SUCCESSFUL MODEL TO ADOPT IN TRANSFORMATIVE GEOSCIENCES WORK ACROSS DISCIPLINES. THROUGH BROADENING PARTICIPATION OF UNDERREPRESENTED GROUPS AND BUILDING AND ENHANCING PARTNERSHIPS WITH COMMUNITY ADVOCACY GROUPS, THE CSAW LEARNING ECOSYSTEM WILL PROVIDE A PROTOTYPE TO PROMOTE GEOSCIENCE TRANSFORMATIONS AT OTHER INSTITUTIONS AND ACROSS DISCIPLINES. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

COINSTAC: DECENTRALIZED, SCALABLE ANALYSIS OF LOOSELY COUPLED DATA

UNIVERSITY TRANSPORTATION CENTER

AMPK AS A REDOX SENSOR AND MODULATOR

TRANSITION TO TEACHING PROGRAM -- NATIONAL

(MURI 06) INTEGRATED FUSION, PERFORMANCE PREDICTION, AND SENSOR MANAGEMENT FOR AUTOMATIC TARGET EXPLOITATION

INNOVATIONS IN DEVELOPING RESIDENT EDUCATORS AND MENTORS

DEVELOPMENT OF THE OHIO STATE UNIVERSITY LABORATORY FOR ADVANCED LASER-TARGET INTERACTIONS (LALTI) FOR APPLICATION IN HIGH ENERGY DENSITY SCIENCE & D

TAS::57 3600::TAS "(MURI FY10) CRYOGENIC PELTIER COOLING"

MINING THE GENOMEWIDE SCAN: GENETIC PROFILES OF STRUCTURAL LOSS IN SCHIZOPHRENIA

NOVEL INFLUENZA A NANOVACCINES FOR BROAD CROSS PROTECTION

SAN JOSE STATE UNIVERSITY UNDERGRADUATE MBRS RISE PROGRAM

NEISSERIA GONORRHOEAE METAL TRANSPORTERS THAT SUBVERT NUTRITIONAL IMMUNITY

INTERROGATING STRESS-RELIEVING NEURAL CIRCUITS TO ALLEVIATE CARDIOVASCULAR DISEASE

THE PRESENT UNSOLICITED PROPOSAL REQUESTS FUNDING OF A THREE-YEAR COOPERATIVE AGREEMENT BETWEEN THE ARMY AEROFLIGHTDYNAMICS DIRECTORATE (AFDD) AT THE

IDENTIFICATION AND PRE-CLINICAL EVALUATION OF MEASLES VIRUS INHIBITORS

THE PRESENT PROPOSAL REQUESTS FUNDING OF A THREE-YEAR COOPERATIVE AGREEMENT BETWEEN THE ARMY AEROFLI

SHIP OPERATIONS R/V POINT SUR 2012 - 2016

NSEC: CENTER FOR AFFORDABLE NANOENGINEERING OF POLYMER BIOMEDICAL DEVICES (CANPBD)

SHIP OPERATIONS

PROJECT ENGINEERING SUCCESS: INCREASING HISPANIC STUDENT SUCCESS IN ENGINEERING AT SAN JOSE STATE UNIVERSITY, SAN JOSE CITY COLLEGE AND GAVILAN COLLEGE

EXPERIMENTAL NUCLEAR PHYSICS

PATHOPHYSIOLOGY OF TLR5KO COLITIS

CREST CENTER FOR DYNAMIC MULTISCALE AND MULTIMODAL BRAIN MAPPING OVER THE LIFESPAN [D-MAP]

TAS::89 0328::TAS RECOVERY - NEW AWARD THE OHIO STATE UNIVERSITY. I-SMART: INTEGRATED CURRICULUM FOR SMART POWER ENGINEERING. AWARD IS TO FACILITAT

DEVELOPMENT OF A BROAD-SPECTRUM INHIBITOR AGAINST SEASONAL AND HIGHLY-PATHOGENIC INFLUENZA VIRUSES

REUTTER: OHIO SEA GRANT COLLEGE PROGRAM FEBRUARY 2010-JANUARY 2012

AMP-ACTIVATED KINASE IN DIABETIC COMPLICATIONS

VIRGINIA SPACE GRANT CONSORTIUM

INCREMENTAL FUNDING

RECOVERY ACT GREEN JOBS

LEADERSHIP EDUCATION IN NEURODEVELOPMENTAL AND RELATED DISORDERS TRAINING PROGRAM

DECONSTRUCTING INFLAMMATION AND ALTERED MICROBIOTA IN METABOLIC SYNDROME

HUMAN-SYSTEM INEGRATION TECHNOLOGIES

EXPLORING THE MILLIARCSECOND FRONTIER: OPEN ACCESS TO THE RENEWED CHARA ARRAY

NEURONS EXPRESSING ANGIOTENSIN TYPE 2 RECEPTORS IN THE NTS AS AN ACCESS POINT FOR CARDIOVASCULAR CONTROL.

ADVANCING INNOVATIVE PARTNERSHIPS AND PATHWAYS TO ADDRESS MENTAL HEALTH WORKFORCE SHORTAGES IN GEORGIA SCHOOLS

MARC U STAR AT SAN JOSE STATE UNIVERSITY

SAN JOSE STATE UNIVERSITY PROPOSES A MULTI-UNIVERSITY CONSORTIUM (C-STTAR) TO ESTABLISH A CLIMATE CHANGE AND EXTREMEEVENTS TRAINING AND RESEARCH (CCEETR) PROGRAM. THE PROGRAM OBJECTIVE IS TO CONDUCT, RESEARCH, EDUCATION, ANDTECHNOLOGY TRANSFER ACTIVITIES TO IMPROVE THE RAIL NETWORK S SAFETY AND RESILIENCE AGAINST EXTREME EVENTS, INCLUDING CLIMATECHANGE. THE APPLICANT WILL FOCUS ON FIVE PROJECTS DIRECTED AT EDUCATING THE RAILROAD COMMUNITY AND EVALUATING ANDDEMONSTRATING TECHNOLOGIES AND APPROACHES THAT SHOW PROMISE FOR MITIGATING THE CONSEQUENCES OF EXTREME EVENTS ONRAILROAD OPERATIONS: APPLICATION OF EMERGING TECHNOLOGIES TO CREATE EVALUATION AND SIMULATION SCENARIOS FOR RAILROAD PERSONNELTRAINING CREATION AND DELIVERY OF TRAINING PROGRAMS THAT CAN BE USED BY FREIGHT AND PASSENGER RAILROADS TO ENHANCE THEIRABILITY TO DEVELOP RESPONSE PROGRAMS TO ENHANCE RESILIENCY. DEVELOPMENT OF PREDICTIVE ASSESSMENT TOOLS TO SUPPORTDETECTION, ALERT, AND WARNING SYSTEMS PLANNING, OPERATIONS, RESPONSE, AND RECOVERY FROM EMERGENCIES AND DISRUPTIVE EVENTS ENHANCE TECHNOLOGY TRANSFER, CAREER PATHWAYS, ECONOMIC AND WORKFORCE DEVELOPMENT FOR MINORITY, SMALL BUSINESSES, ANDUNDERSERVED COMMUNITIES EVALUATION AND DEMONSTRATION OF SENSORS ON MOBILE AND FIXED PLATFORMS TO IDENTIFY RISKS FOR THENORTH AMERICAN RAIL NETWORK

PIRE: CENTENNIAL GENETIC AND SPECIES TRANSFORMATIONS IN THE EPICENTER OF MARINE BIODIVERSITY

WESTERN KENTUCKY UNIVERSITY RESEARCH FOUNDATION, INC.

THE MOTIVATION FOR THE ESTABLISHMENT OF A NASA MIRO CENTER FOR APPLIED ATMOSPHERIC RESEARCH AND EDUCATION (CAARE) AT SAN JOSE STATE UNIVERSITY (SJSU)

EXPERIMENTAL AND COMPUTATIONAL TOOLS FOR THE DIGITAL REPRESENTATION AND PREDICTION OF MICROSTRUCTURE AND IT'S INCORPORATION IN THE DESIGNER'S KNOWLED

SAN JOSE GEAR UP COMMUNITY ACHIEVEMENT PROJECT

LEADERSHIP EDUCATION IN NEURODEVELOPMENTAL AND RELATED DISORDERS TRAINING PROGRAM

NOVEL NONLINEAR OPTICAL PROCESSES IN ACTIVE, RANDOM AND NANOSTRUCTURED SYSTEMS

"SCIENTIFIC CHALLENGES ASSOCIATED WITH MULTI-MATERIALS SYSTEM WITH ADAPTIVE MICROSTRUCTURES FOR AEROSPACE APPLICATIONS"

TEACHER QUALITY ENHANCEMENT GRANTS FOR STATE AND PARTNERSHIPS - PARTNERSHIP GRANTS

NEUROCOGNITIVE BASES OF TREATMENT RESISTANCE IN DEVELOPMENTAL DYSLEXIA

REACTIVE NITROGEN AND ACCELERATED ATHEROSCLEROSIS IN TYPE I DIABETES

VIRGINIA SPACE GRANT CONSORTIUM FY2020-2024

DISABILITY AND REHABILITATION RESEARCH PROJECTS

INFLUENZA VACCINES INDUCING BROADLY CROSS PROTECTIVE IMMUNITY

ADDRESSING SOCIAL DETERMINANTS OF HEALTH IN THE MOST DIVERSE SQUARE MILE IN AMERICA

STRUCTURE-BASED DESIGN OF CORONAVIRUS SUBUNIT VACCINES

PROJECT 6 - THE EXPRESSION OF HUMAN CATALYTIC PROTEINS IN MICRO ALGAE ON A COMMERCIAL SCALE

RATIONAL DESIGN AND EVALUATION OF NOVEL MRNA VACCINES AGAINST MERS-COV

BIOBEHAVIORAL FOUNDATIONS AND DEVELOPMENT OF COGNITIVE COMPETENCE

FY 2009 TEACHER QUALITY PARTNERSHIPS GRANTS

"A THEORETICALLY DRIVEN INVESTIGATION OF THE EFFICACY OF AN IMMERSIVE INTERACTIVE AVATAR"

ADVANCE INSTITUTIONAL TRANSFORMATION AWARD: COMPREHENSIVE EQUITY AT OHIO STATE (CEOS)

UNIVERSITY TRANSPORTATION CENTERS

CYBERCORPS SCHOLARSHIP FOR SERVICE: PREPARING FUTURE CYBERSECURITY LEADERS THROUGH APPLIED LEARNING EXPERIENCES

ADVANCING RURAL COMPUTER SCIENCE (ARCS)

NURSE EDUCATION, PRACTICE, QUALITY AND RETENTION

ENABLING MILLIARCSECOND ASTROPHYSICS: OPEN ACCESS FOR THE CHARA ARRAY

NOVEL NANOBODIES TO PREVENT AND TREAT SARS-COV-2 AND OTHER PATHOGENIC HUMAN CORONAVIRUSES

SNAP NUTRITION OBESITY GRANT

MULTIVALENT NANOCLUSTER UNIVERSAL INFLUENZA VACCINE GIVEN BY MICRONEEDLE PATCH

ENHANCING SAFETY AND WELL-BEING OF CHILDREN OF ADULT DRUG COURT PARTICIPANTS

COMMUNICATING ABOUT NICOTINE AND DIFFERENTIAL RISKS OF TOBACCO PRODUCTS

VLP VACCINE TECHNOLOGY

DATA DRIVEN DYNAMIC ACTIVITY/CONNECTIVITY METHODS FOR EARLY DETECTION OF ALZHEIMER?S - PROJECT SUMMARY/ABSTRACT THE DEVELOPMENT OF BIOMARKERS FOR IDENTIFYING PRECLINICAL OR PRODROMAL ALZHEIMER’S DISORDER ARE OF GREAT IN- TEREST. WHILE SOME INITIAL RESULTS BASED ON RESTING FMRI HAVE BEEN PRESENTED, ACCURACY, ROBUSTNESS, AND RELIA- BILITY ARE STILL RELATIVELY LOW. ONE HIGHLY PROMISING DIRECTION IS THE DEVELOPMENT OF DYNAMIC FUNCTIONAL ACTIVITY AND FUNCTIONAL CONNECTIVITY APPROACHES. THESE APPROACHES HAVE BEEN SHOWN TO BE ESPECIALLY PROMISING MOST LIKELY DUE TO THE HIGHLY DYNAMIC NATURE OF THE BRAIN AND THE UNCONSTRAINED NATURE OF RESTING FMRI. CURRENTLY, THERE ARE NO METHODS THAT CAN PROVIDE A FULL CHARACTERIZATION OF TEMPORAL, SPATIAL, AND SPATIO-TEMPORAL DYNAMICS NOR CAN MOST EXISTING APPROACHES CHARACTERIZE HETEROGENOUS SUBGROUPS OR COMPLEX MULTISCALE RELATIONSHIPS. WE WILL DEVELOP NEW METHODS THAT CAN EFFECTIVELY CAPTURE DYNAMIC CONNECTIVITY AND PROVIDE SUMMARY METRICS WITH A FOCUS ON INDIVIDUALIZED PREDICTION OF ALZHEIMER’S DISEASE WELL PRIOR TO THE ONSET OF THE ILLNESS. WE PROPOSE A NOVEL FAMILY OF MODELS THAT BUILDS ON THE WELL-STRUCTURED FRAMEWORK OF JOINT BLIND SOURCE SEPARATION TO CAPTURE A MORE COMPLETE CHARACTERIZATION OF (POTENTIALLY NONLINEAR) SPATIO-TEMPORAL DYNAMICS. OUR MODELS WILL ALSO PRO- DUCE A RICH SET OF METRICS TO CHARACTERIZE THE AVAILABLE DYNAMICS AND ENABLE IN DEPTH COMPARISON WITH CURRENTLY AVAILABLE MODELS. WE SHOW EVIDENCE THAT SUCH MEASURES ARE LIKELY TO BE CONSIDERABLY MORE SENSITIVE AND MORE ACCURATE IN CLASSIFYING INDIVIDUALS. WE WILL EXTENSIVELY VALIDATE OUR APPROACHES IN A VARIETY OF WAYS INCLUDING SIMULATIONS, CONCURRENT EEG/FMRI DATA, AND EVALUATION ON A LARGE NORMATIVE DATA SET. WE WILL APPLY THE DEVEL- OPED METHODS TO SEVERAL LARGE DATASETS INCLUDING A LARGE LONGITUDINAL SAMPLE OF INDIVIDUALS WHO HAVE BEEN SCANNED AT EMORY UNIVERSITY WITH RESTING FMRI WHO ALSO HAVE CSF AMYLOID AND TAU PET MEASURES. WE WILL USE THE DEVELOPED MARKERS TO PREDICT COGNITIVE DECLINE, AMYLOID, AND TAU LEVELS IN THESE DATA AND INCLUDE BOTH A DISCOVERY DATA SET AS WELL AS AN INDEPENDENT REPLICATION DATA SET. SUCCESSFUL COMPLETION OF OUR AIMS WILL BE AN IMPORTANT FIRST STEP TOWARDS PROVIDING AN OPPORTUNITY TO DEVELOP AND EVALUATE INTERVENTIONS EARLY ENOUGH TO HAVE A POSITIVE IMPACT ON LONG-TERM PROGNOSIS. WE WILL PROVIDE OPEN SOURCE TOOLS AND RELEASE DATA THROUGHOUT THE DURATION OF THE PROJECT VIA GITHUB, A WEB PORTAL AND THE NITRC REPOSITORY, HENCE ENABLING OTHER INVESTIGATORS TO COMPARE THEIR OWN METHODS WITH OUR OWN AS WELL AS TO APPLY THEM TO A LARGE VARIETY OF BRAIN DISORDERS. OUR TOOLS ALSO HAVE WIDE APPLICATION TO THE STUDY OF THE HEALTHY BRAIN AS WELL AS MANY OTHER DISEASES. 37

RESEARCH IN HEAVY ION NUCLEAR REACTIONS

MALE/FEMALE DIFFERENCES IN PSYCHOSIS AND MOOD DISORDERS:DYNAMIC IMAGING-GENOMIC MODELS FOR CHARACTERIZING AND PREDICTING PSYCHOSIS AND MOOD D

MOBY LWN TIME-SERIES UNCERTAINTY REDUCTION AND SYSTEM ENHANCEMENTS FOR IMPROVED VICARIOUS CALIBRATION ACROSS MULTIPLE AGENCY OCEAN COLOR SATELLITE MI

POLYMERASE INHIBITORS OF RESPIRATORY SYNCYTIAL VIRUS

MEANINGFUL ENGAGEMENT AND QUALITY OF LIFE AMONG ASSISTED LIVING RESIDENTS WITH DEMENTIA

ASSESSING THE INTENDED AND UNINTENDED CONSEQUENCES OF E-CIGARETTE TV ADVERTISING

VSGC ALIGNS WITH THE NATIONAL SPACE GRANT PROGRAM OBJECTIVES OF: (1) PROMOTING A STRONG STEM EDUCATION BASE FROM ELEMENTARY THROUGH SECONDARY LEVELS

FY 2009 TEACHER QUALITY PARTNERSHIPS GRANTS

CONTROLLING VSMC PROLIFERATION AND MIGRATION

EXAMINING CARBON MONOXIDE TO TREAT INFLAMMATORY CONDITIONS USING EXPERIMENTAL COLITIS MODELS

"(GAMECHANGER) -MULTIFUNCTIONAL DESIGN OF HYBRID COMPOSITES OF LOAD BEARING ANTENNAS" REVISED 23 APR 07

HIGH ANGULAR RESOLUTION COMMUNITY SCIENCE AT THE CHARA ARRAY -THE CENTER FOR HIGH ANGULAR RESOLUTION ASTRONOMY (CHARA) ARRAY IS THE NATION?S PREMIER FACILITY FOR LONG BASELINE OPTICAL INTERFEROMETRY. WITH THE NUMBER AND SIZE OF ITS TELESCOPES, THE LENGTH OF ITS BASELINES, AND THE RANGE OF WAVELENGTHS COVERED BY ITS BEAM COMBINERS, THE CHARA ARRAY IS A UNIQUELY POWERFUL FACILITY FOR MILLIARCSECOND IMAGING. WITH ADAPTIVE OPTICS AND FOUR NEW BEAM COMBINERS, THE ARRAY IS REACHING DEEPER THAN EVER. SINCE 2004 CHARA RESULTS HAVE APPEARED IN SOME 245 PAPERS IN THE REFEREED LITERATURE. THIS INCLUDES OBSERVATIONS OBTAINED DURING THE HIGH-DEMAND OPEN ACCESS PROGRAM SUPPORTED BY NSF FOR SOME YEARS, AND OPERATED IN COLLABORATION WITH NSF?S NATIONAL OPTICAL-INFRARED RESEARCH LABORATORY. THIS AWARD EXTENDS THAT PROGRAM FOR ANOTHER THREE YEARS, AND INCLUDES A NEW SNAPSHOT IMAGING MODE. THE TEAM ALSO PLANS TO OFFER USER SUPPORT, COMMUNITY WORKSHOPS, AND AN ACCESSIBLE DATA ARCHIVE. CHARA WILL FOSTER COLLABORATIONS WITH AMATEUR ASTRONOMERS THROUGH THE AMERICAN ASSOCIATION OF VARIABLE STAR OBSERVERS. CHARA TRAINS GRADUATE STUDENTS TO BUILD AND USE PRECISION TECHNOLOGY. THE CHARA ARRAY ACHIEVES SUB-MILLIARCSECOND RESOLUTION AT VISIBLE AND NEAR-INFRARED WAVELENGTHS, AND CAN BE USED TO RESOLVE THE RADII OF STARS ALL ALONG THE MAIN SEQUENCE AND AT DIFFERENT STAGES AS STARS EVOLVE OFF THE MAIN SEQUENCE. THE ARRAY REVEALS THE IMPACT OF LIMB- AND GRAVITY-DARKENING, THE SPATIAL DISTRIBUTION AND SIZE OF STAR-SPOTS AND ACTIVITY IN CONVECTION ZONES, AND PROVIDES PHYSICAL PROPERTIES OF EXOPLANET HOST STARS. THE CHARA ARRAY RESOLVES BINARY STARS, MAPS ORBITS, AND PROBES INTERACTING SYSTEMS. EXTRAGALACTIC OBSERVATIONS PROBE THE STRUCTURE OF ACTIVE GALACTIC NUCLEI CORES TO SHOW HOW SUPERMASSIVE BLACK HOLES IMPACT ACCRETION AND TRIGGER OUTFLOWS. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

WRITING IN ADULT SECONDARY EDUCATION CLASSES (W-ASE)

(SURI) SPACE DOMAIN AWARENESS IN A PHOTON-STARVED ENVIRONMENT (SDAPSE)

UNIVERSITY TRANSPORTATION CENTER - TRANSPORTATION SYSTEMS POLICY AND MANAGEMENT

COLLABORATIVE RESEARCH: IPY: POLENET-ANTARCTICA: INVESTIGATING LINKS BETWEEN GEODYNAMICS AND ICE SHEETS

FLEXIBLE MULTIVARIATE MODELS FOR LINKING MULTI-SCALE CONNECTOME AND GENOME DATA IN ALZHEIMER'S DISEASE AND RELATED DISORDERS

PHOTOPERIODIC CONTROL OF OBESITY

LIGHTWEIGHT INTERMETALLICS FOR HYDROGEN STORAGE

ADVANCED OPTICAL FIBERS FOR HIGH POWER FIBER LASERS

MISSION STATEMENT: THE VIRGINIA SPACE GRANT CONSORTIUM ACTS AS AN UMBRELLA ORGANIZATION COORDINATING AND DEVELOPING QUALITY AEROSPACE-RELATED HIGH

DEVELOPING INHIBITORS OF SEASONAL AND PANDEMIC INFLUENZA VIRUSES - SUMMARY INFLUENZA VIRUSES ARE A LEADING CAUSE OF HUMAN DISEASE DUE TO RESPIRATORY VIRAL INFECTION WORLDWIDE. IT IS THE OVERARCHING OBJECTIVE OF THIS PROJECT TO ADVANCE PRODRUG CONJUGATES OF 4’-FLUOROURIDINE (4’-FLU), A NOVEL PYRIMIDINE ANALOG WITH CONFIRMED BROAD ORAL EFFICACY AGAINST INFLUENZA VIRUSES, AND AT LEAST ONE NON-NUCLEOSIDE INHIBITOR OF THE INFLUENZA VIRUS POLYMERASE COMPLEX, TO THE STAGE OF FORMAL PRECLINICAL DEVELOPMENT AND ASSEMBLY OF AN INVESTIGATIONAL NEW DRUG-ENABLING PACKAGE. THE PROJECT DESIGN IS DRIVEN BY OUR UNDERLYING HYPOTHESIS THAT EFFECTIVE NEXT-GENERATION THERAPEUTICS FOR THE TREATMENT OF INFLUENZA MUST BE ORALLY AVAILABLE, DISPLAY A BROAD INDICATION SPECTRUM AGAINST INFLUENZA VIRUS ISOLATES OF HUMAN, AVIAN, AND SWINE LINEAGES, AND IDEALLY COVER BOTH INFLUENZA A (IAV) AND B (IBV) VIRUSES. THESE PRODUCT PROFILE DEMANDS ARE DERIVED FROM THE CLINICAL BURDEN IMPOSED BY THE DIVERSE SPECTRUM OF SEASONAL INFLUENZA VIRUSES, THE PANDEMIC POTENTIAL ARISING FROM SPILLOVER OF ZOONOTIC AVIAN VIRUSES INTO THE HUMAN POPULATION, AND CURRENT FDA RECOMMENDATIONS THAT RECOGNIZE OUTPATIENT ADULTS SUFFERING FROM SEASONAL INFLUENZA AS THE PRIMARY PATIENT POPULATION FOR INITIAL CLINICAL TESTING. THESE DEVELOPMENTAL OBJECTIVES ARE BEST MET WITH DIRECT ACTING THERAPEUTICS, SINCE HOST-TARGETED ANTIVIRAL THERAPIES, ALTHOUGH OFTEN TANTALIZINGLY BROAD IN INDICATION RANGE, ARE PRONE TO UNACCEPTABLE SIDE EFFECTS THAT ARE INCOMPATIBLE WITH THE PRIMARY PATIENT GROUP PURSUED. IN PREVIOUS WORK UNDERPINNING THIS PROGRAM, WE HAVE DEMONSTRATED BROAD-SPECTRUM ANTIVIRAL ACTIVITY OF 4’-FLU IN CULTURED CELLS AND ANIMAL INFECTION MODELS AGAINST A CLINICALLY SIGNIFICANT PANEL OF RNA VIRUSES. AGAINST THE INFLUENZA VIRUS INDICATION, 4’-FLU HAS CONFIRMED ORAL EFFICACY AGAINST SEASONAL, PANDEMIC, AND HIGHLY PATHOGENIC AVIAN INFLUENZA VIRUSES IN RODENT AND NON-RODENT MODELS. THE COMPOUND TRIGGERS IMMEDIATE CHAIN TERMINATION OF THE INFLUENZA VIRUS RNA-DEPENDENT RNA POLYMERASE (RDRP) COMPLEX AND CARRIES A HIGH BARRIER TO VIRAL RESISTANCE. IN PREPARATION OF CLINICAL DEVELOPMENT, WE HAVE GENERATED PRODRUG CONJUGATES OF 4’-FLU TO OPTIMIZE DELIVERY ACROSS THE GASTROINTESTINAL EPITHELIUM. TO BROADEN OUR INFLUENZA VIRUS RDRP INHIBITOR PORTFOLIO, WE HAVE IDENTIFIED A SET OF NON-NUCLEOSIDE RDRP INHIBITORS IN A LARGE-SCALE HIGH-THROUGHPUT SCREENING CAMPAIGN THAT WILL BE ADVANCED SIMULTANEOUSLY AS COMPANION DRUGS OR FOR COMBINATION THERAPY IN A MULTI- PRONGED APPROACH. TO SELECT A CLINICAL CANDIDATE FOR FORMAL DEVELOPMENT, 4’-FLU PRODRUG CONJUGATES WILL BE SUBJECTED TO DE-RISKING EFFICACY AND TOLERABILITY TESTING IN RELEVANT RODENT AND NON-RODENT ANIMAL MODELS AND DOSING PARADIGMS EXPLORED THROUGH INTERFACING OF DYNAMIC PK PROFILES WITH PERFORMANCE IN HUMAN AIRWAY EPITHELIUM ORGANOIDS (AIM 1). NON-NUCLEOSIDE RDRP INHIBITOR LEAD CANDIDATE SCAFFOLDS WILL BE SYNTHETICALLY DEVELOPED, MECHANISTICALLY CHARACTERIZED, AND SUBJECTED TO PROOF-OF-CONCEPT EFFICACY TESTING (AIM 2). EMERGING NON-NUCLEOSIDE LEADS WILL BE QUERIED FOR COMBINATION THERAPY WITH THE 4’-FLU CLINICAL CANDIDATE AND THE EFFECT OF MONO- AND COMBINATION THERAPY ON SUPPRESSING INFLUENZA VIRUS TRANSMISSION DETERMINED IN FERRETS (AIM 3).

1) TO SUPPORT FOR A PROGRAM AS DESCRIBED IN "DUAL MASTER'S PROGRAM IN APPLIED ECONOMMICS FOR INDONESIANS";2) TO OBLIGATE FUNDS $805 267;3) TO PR

PERSONALIZED INTEGRATED ALCOHOL AND SEXUAL ASSAULT PREVENTION AMONG COLLEGE STUDENTS - PROJECT ABSTRACT THE OVERARCHING GOAL OF THIS R01 IS TO TEST THE EFFICACY OF A BEHAVIORAL INTERVENTION FOR HEAVY EPISODIC DRINKING (HED) AND SEXUAL ASSAULT AMONG COLLEGE STUDENTS. SEXUAL AND GENDER MINORITY (SGM) STUDENTS EXPERIENCE SEXUAL ASSAULT AND ENGAGE IN HED AT EVEN HIGHER RATES THAN THEIR CISGENDER, HETEROSEXUAL PEERS. THEREFORE, TAILORED AND PERSONALIZED INTERVENTIONS ARE NEEDED FOR HED AND SEXUAL ASSAULT TO ADDRESS THE UNIQUE NEEDS OF COLLEGE STUDENTS BASED ON GENDER IDENTITY AND SEXUAL ORIENTATION. THE ALCOHOL AND SEXUAL ASSAULT PREVENTION (ASAP) PROGRAM WAS DEVELOPED BY THE RESEARCH TEAM WITH AN NIAAA-FUNDED PLANNING GRANT (R34) AND IS THE ONLY INTERVENTION THAT TARGETS BOTH HED AND SEXUAL ASSAULT (VICTIMIZATION RISK REDUCTION, PERPETRATION PREVENTION, AND BYSTANDER INTERVENTION TRAINING) IN AN INTEGRATED MANNER. ASAP PROVIDES TAILORED CONTENT ON ALCOHOL USE AND SEXUAL ASSAULT BASED ON GENDER IDENTITY AND SEXUAL ORIENTATION USING A SOCIAL NORMS AND PERSONALIZED FEEDBACK APPROACH. USABILITY TESTING AND FINDINGS FROM A RANDOMIZED CONTROLLED PILOT FEASIBILITY TRIAL SUGGEST USABILITY, FEASIBILITY, AND PRELIMINARY EFFICACY AND WARRANT RIGOROUS RANDOMIZED CONTROLLED TRIAL TESTING. ASAP IS DELIVERED IN A BRIEF, WEB-BASED FORMAT, AND ALTHOUGH SHORT-TERM OUTCOMES ARE PROMISING, MORE EFFORT IS NEEDED TO ENSURE LONG-TERM EFFICACY. THEREFORE, THE CURRENT STUDY INCLUDES AN ASSESSMENT OF ASAP AS WELL AS AN INNOVATIVE ASSESSMENT OF A 6-MONTH BOOSTER (ASAP+BOOSTER) SESSION TO DETERMINE THE MOST EFFECTIVE WAY TO DISSEMINATE ASAP TO COLLEGES NATIONWIDE IF FOUND TO BE EFFECTIVE. THE CURRENT STUDY INCLUDES THE FOLLOWING AIMS: 1A) TO TEST THE EFFICACY OF ASAP AND ASAP+BOOSTER AMONG COLLEGE STUDENTS IN REDUCING HED AND SEXUAL ASSAULT BOTH SHORT- AND LONG-TERM AMONG THREE RISK GROUPS (1. CISGENDER HETEROSEXUAL MEN; 2. CISGENDER HETEROSEXUAL WOMEN; 3. SGM); 1B) TEST THE RELATIVE EFFICACY OF A BOOSTER SESSION ON LONG-TERM ALCOHOL USE AND SA OUTCOMES; AND 2) INVESTIGATE THE MECHANISMS THROUGH WHICH ASAP CONDITIONS IMPACT ALCOHOL USE AND SA. OUTCOMES WILL BE ASSESSED AT 3-, 6-, 9-, AND 12-MONTHS POST- INTERVENTION. BY ACCOMPLISHING THESE AIMS, WE WILL ASSESS THE EFFICACY OF ASAP, A PROMISING INTERVENTION DEVELOPED BY THE RESEARCH TEAM. ASAP HAS THE POTENTIAL TO REDUCE ALCOHOL USE AMONG YOUNG ADULTS AS WELL AS REDUCE COLLEGE SA AND INCLUDES A FOCUS ON SGM POPULATIONS, ADDRESSING NIAAA AND PUBLIC HEALTH PRIORITIES.

SEX DIFFERENCES IN THE SOCIAL BRAIN

LIBERATE

"(03 MURI) GENETICALLY-ENGINEERED MICRODEVICRS (GEMS) WITH TAILORED 3-D SHAPES, NANOSCALE FEATURES, AND CHEMISTRIES"

PROMOTING PROSOCIAL BYSTANDER BEHAVIOR IN INTOXICATED MEN: EVALUATION OF REALCONSENT2.0

NEUROBIOLOGY OF SOCIAL BEHAVIOR

GRADUATE RESEARCH FELLOWSHIP PROGRAM

PAWS: EFFICACY

INFANT-TODDLER COURT PROGRAM - CENTER OF EXCELLENCE FOR CHILDREN’S BEHAVIORAL HEALTH GEORGIA HEALTH POLICY CENTER GEORGIA STATE UNIVERSITY 55 PARK PLACE, ATLANTA, GA 30303 (404) 413-0314 HTTPS://GACOEONLINE.GSU.EDU/ PROJECT DIRECTOR: ANN MUKHERJEE, MPP EMAIL ADDRESS: AHEDGES@GSU.EDU THE CENTER OF EXCELLENCE FOR CHILDREN’S BEHAVIORAL HEALTH (COE OR CENTER) IS SEEKING HRSA FUNDING OPPORTUNITY HRSA-22-073, INFANT-TODDLER COURT PROGRAM – STATE AWARD. THE CENTER IS SEEKING $625,000 PER YEAR FOR A 5-YEAR PROJECT PERIOD. THE CENTER PROPOSES A 5-YEAR PROJECT BEGINNING WITH A YEARLONG PLANNING PHASE TO DEVELOP AN INFANT-TODDLER COURT (ITC) LEADERSHIP TEAM AND STATEWIDE ACTION PLAN THAT WILL GUIDE 4 YEARS OF ITC IMPLEMENTATION. DURING IMPLEMENTATION, THE COE WILL INITIATE 3 ITC TEAMS IN LOCAL JURISDICTIONS THROUGH A REQUEST FOR APPLICATIONS (RFA) PROCESS AND PROVIDE STATEWIDE LEADERSHIP AND COORDINATION TO INCREASE CAPACITY FOR AND KNOWLEDGE OF THE ITC APPROACH ACROSS THE STATE. THE GOAL OF GEORGIA’S INFANT-TODDLER COURT (ITC) PROGRAM IS TO IMPROVE STATEWIDE SYSTEMS AND POLICIES TO SUPPORT YOUNG CHILDREN (AGES 0-3) AND THEIR FAMILIES WHO ARE INVOLVED, OR AT RISK OF INVOLVEMENT, WITH THE CHILD WELFARE SYSTEM, AND BUILD CAPACITY TO PREVENT CHILD MALTREATMENT MORE BROADLY. THE STATE WILL ACHIEVE THIS GOAL BY EXPANDING EVIDENCE-BASED INFANT-TODDLER COURT TEAMS AND IMPROVING EARLY DEVELOPMENTAL HEALTH AND WELL-BEING OF INFANTS, TODDLERS, AND THEIR FAMILIES BY COMPLETING THE FOLLOWING OBJECTIVES: ESTABLISH LEADERSHIP CAPACITY IN GEORGIA TO INFORM ITC IMPLEMENTATION THROUGH THE CREATION AND TRAINING OF A STATE-LEVEL ITC LEADERSHIP TEAM. THE LEADERSHIP TEAM WILL INCLUDE STATE-LEVEL PARTNERS, LOCAL LEADERS, AND FAMILIES WITH LIVED EXPERIENCE. DEVELOP A STATE ACTION PLAN TO GUIDE ITC IMPLEMENTATION IN THE STATE THROUGH A SYSTEMATIC PROCESS LED BY THE STATE-LEVEL ITC LEADERSHIP TEAM AND INVOLVING THE ITC NATIONAL RESOURCE CENTER, RELEVANT STAKEHOLDERS, AND FAMILIES WITH LIVED EXPERIEN CE. INCREASE CAPACITY THROUGH TRAINING OF STATE AND LOCAL PARTNERS IN THE ITC APPROACH AND TOPICS RELATED TO THE DEVELOPMENTAL HEALTH, MENTAL HEALTH, AND WELL-BEING OF VERY YOUNG CHILDREN. ESTABLISH LOCAL CAPACITY FOR ITC IMPLEMENTATION BY ESTABLISHING THREE LOCAL ITC SITES THROUGH A REQUEST FOR APPLICATIONS PROCESS INFORMED BY THE STATE ACTION PLAN, ITC LEADERSHIP TEAM, AND FAMILIES WITH LIVED EXPERIENCE. IMPROVE YOUTH AND FAMILY OUTCOMES DURING AND AFTER CHILD WELFARE AND/OR COURT INVOLVEMENT DEMONSTRATED THROUGH COLLECTION AND EVALUATION OF PROGRAM OUTCOMES DATA AT THE THREE LOCAL ITC SITES. ESTABLISH SUSTAINABILITY AND SCALING PLANS UTILIZING EVALUATION DATA AND LEARNINGS FROM IMPLEMENTATION TO INFORM SUSTAINABILITY AND FUTURE SCALING OF THE MODEL ACROSS GEORGIA. THE COE IS POSITIONED TO LEAD THIS WORK GIVEN ITS CURRENT LEADERSHIP IN STATEWIDE INITIATIVES BUILDING INFANT AND EARLY CHILDHOOD SYSTEMS OF CARE AND DEVELOPING SYSTEMS OF CARE FOR CHILDREN WITH BEHAVIORAL HEALTH NEEDS. THE CENTER HAS ESTABLISHED MULTI-SECTOR AND CROSS-AGENCY PARTNERSHIPS THROUGHOUT THE STATE, INCLUDING CONNECTIONS AND ENGAGEMENT WITH FAMILIES WHO HAVE LIVED EXPERIENCE NAVIGATING SERVICES FOR THEIR YOUNG CHILDREN ACROSS MULTIPLE STATE AGENCIES. THE COE AND ITS PARTNERS RECOGNIZE THE INCREDIBLE IMPORTANCE OF THE PRENATAL TO 3 PERIOD OF LIFE. THIS FOUNDATION OF COMMON UNDERSTANDING THAT YOUNG CHILDREN HAVE UNIQUE DEVELOPMENTAL NEEDS IS A STRENGTH OF THE STATE PARTNERS AND WILL HELP THE LEADERSHIP TEAM TRANSITION QUICKLY FROM KICK-OFF TO PLANNING AND IMPLEMENTATION.

ESTABLISHING SMOKE-FREE HOMES WITH FAMILIES INVOLVED IN CHILD PROTECTIVE SERVICES: AN EFFECTIVENESS-IMPLEMENTATION TRIAL OF AN INTEGRATED PROGRAM - PROJECT ABSTRACT CHILD EXPOSURE TO SECONDHAND SMOKE (SHS) IS LINKED TO MULTIPLE FORMS OF CANCER THROUGHOUT THE LIFESPAN. YOUNG CHILDREN LIVING IN LOW-SOCIOECONOMIC STATUS HOUSEHOLDS ARE AT INCREASED RISK FOR SHS EXPOSURE. FAMILIES INVOLVED WITH THE CHILD PROTECTION SYSTEM AS THE RESULT OF SUBSTANTIATED CHILD MALTREATMENT ARE AN ESPECIALLY HIGH-RISK GROUP FOR SHS, AS THESE FAMILIES ARE OFTEN LIVING IN POVERTY AND REPORT HIGH DAILY SMOKING RATES. IMPORTANTLY, CHILD MALTREATMENT VICTIMIZATION ALSO INCREASES RISK OF CANCER AND PREMATURE DEATH FROM CANCER, INDEPENDENT OF PARENT SMOKING BEHAVIOR. IDENTIFYING WAYS TO BROADLY DISSEMINATE EFFECTIVE SHS PREVENTION PROGRAMS TO THESE HIGH-RISK FAMILIES IS AN IMPORTANT STRATEGY FOR REDUCING CANCER DISPARITIES. WE PROPOSE AN EFFECTIVENESS-IMPLEMENTATION HYBRID TRIAL TYPE 1 TO EXAMINE THE IMPACT OF INTEGRATING TWO EVIDENCE-BASED PROGRAMS, SOME THINGS ARE BETTER OUTSIDE (SHS PREVENTION PROGRAM) AND SAFECARE® (CHILD MALTREATMENT PREVENTION PROGRAM), ON ESTABLISHING A SMOKE-FREE HOME AND ON IMPLEMENTATION PROCESS OUTCOMES. AIM 1 FOCUSES ON THE REFINEMENT OF THE STANDARDIZED INTEGRATION (SYSTEMATIC BRAIDING) OF THE TWO PROGRAMS INTO “SMOKE-FREE SAFECARE (SFSC).” AIMS 2 AND 3 FOCUS ON THE HYBRID TRIAL. FIFTY CERTIFIED SAFECARE PROVIDERS WILL BE RECRUITED AND RANDOMLY ASSIGNED TO DELIVER EITHER SFSC OR STANDARD SAFECARE. PROVIDERS WILL EACH SERVE TEN RESEARCH FAMILIES (N = 500) WHO MEET THE INCLUSION CRITERIA (MOTHER OR ANOTHER PERSON RESIDING IN THE HOME SMOKES AT HOME). THE PRIMARY OUTCOME, SMOKE-FREE HOME STATUS, WILL BE MEASURED VIA SELF-REPORT AT 4-TIMEPOINTS (BASELINE, 8-WEEKS, 20-WEEKS, AND 1-YEAR), AND VALIDATED VIA AIR NICOTINE MONITOR AT 8 WEEKS AND 1-YEAR (AIM 2). PROCESS MEASURES WILL BE COLLECTED TO EXAMINE HOW THE BRAIDED INTERVENTION IMPACTS PROVIDER FIDELITY, DELIVERY TIME AND COSTS, AND OTHER PROCESS MEASURES (AIM 3). IF EFFECTIVE, SFSC CAN BE EFFICIENTLY DISSEMINATED FOR WIDESPREAD ADOPTION BY THE NATIONAL SAFECARE TRAINING AND RESEARCH CENTER TO THE OVER 100 ACCREDITED SAFECARE AGENCIES ACROSS THE UNITED STATES AND WORLDWIDE THAT SERVE PARENTS INVOLVED WITH CHILD PROTECTION SERVICES, REDUCING CANCER RISK AND DISPARITIES FOR A HIGH-RISK POPULATION.

ORTHOGONAL UBIQUITIN TRANSFER TO PROFILE E3 SUBSTRATE SPECIFICITY

CYBERCORPS SCHOLARSHIP FOR SERVICE: CYBERSECURITY WORKFORCE PREPARATION IN THE AGE OF ARTIFICIAL INTELLIGENCE -THIS PROJECT AIMS TO ADDRESS THE GROWING NEED FOR A HIGHLY-SKILLED NATIONAL CYBERSECURITY WORKFORCE CAPABLE OF RESPONDING TO RAPIDLY EVOLVING CHALLENGES IN THE AGE OF ARTIFICIAL INTELLIGENCE (AI). WITH FUNDING FROM THE NSF CYBERCORPS(R) SCHOLARSHIP FOR SERVICE (SFS) PROGRAM, GEORGIA STATE UNIVERSITY (GSU) WILL PRODUCE GRADUATES CAPABLE OF ASSUMING A VARIETY OF CYBERSECURITY ROLES IN THE U.S. GOVERNMENT. MOREOVER, THE PROJECT WILL INCREASE THE DIVERSITY OF THE FEDERAL CYBERSECURITY WORKFORCE, LEVERAGING GSU'S POSITION AS A MINORITY-SERVING INSTITUTION (MSI). THE SFS PROJECT WILL EMPHASIZE RECRUITING AND GRADUATING HIGHLY QUALIFIED CANDIDATES FROM GROUPS THAT HAVE REMAINED UNDERREPRESENTED IN THE CYBERSECURITY FIELD, INCLUDING THOSE WITH MILITARY-AFFILIATIONS, FIRST-GENERATION COLLEGE ATTENDEES, AND LOW-INCOME STUDENTS. THIS PROJECT'S UNIQUE AND INNOVATIVE FOCUS WILL IMPACT THE NATION'S COMPETITIVENESS AND THE U.S. GOVERNMENT BY PRODUCING HIGHLY SKILLED CYBERSECURITY PROFESSIONALS WHO CAN DEVELOP AND DEPLOY TRUSTWORTHY CYBERSYSTEMS TO ADDRESS GRAND CHALLENGES FACING SOCIETY. GSU HAS ESTABLISHED A STRONG CURRICULUM IN CYBERSECURITY AND PRIVACY THAT BALANCES TECHNICAL RIGOR AND HANDS-ON EXPERIENCES, OFFERING STUDENTS THE OPPORTUNITY TO STUDY VARIOUS TOPICS IN CYBERSECURITY AND PRIVACY. THE PROJECT FOCUSES ON TRAINING AND PREPARING A WORKFORCE WITH INTEGRATED CYBERSECURITY, PRIVACY, AI, AND MACHINE LEARNING COMPETENCIES TO APPLY AI EXPERTISE TO CYBERSECURITY AND BUILD ROBUST AND TRUSTWORTHY AI SYSTEMS. STUDENTS WILL BE PREPARED WITH THE KNOWLEDGE AND PRACTICAL SKILLS TO APPLY AI EXPERTISE AND UNDERSTAND AI'S SAFETY, SECURITY, PRIVACY, RELIABILITY, FAIRNESS, AND ETHICAL IMPLICATIONS. OVER A FIVE-YEAR PERIOD THE PROJECT WILL PROVIDE SCHOLARSHIPS TO 25 STUDENTS STUDYING ISSUES AT THE INTERSECTION OF CYBERSECURITY AND AI. THE SFS STUDENTS WILL PARTICIPATE IN AN INTENSIVE ACADEMIC PROGRAM IN CYBERSECURITY, PRIVACY, AND TRUSTWORTHY AI, INCLUDING COURSEWORK AND RESEARCH IN CUTTING-EDGE AREAS TO SHARPEN THE STUDENTS' ABILITY FOR CREATIVE THINKING, MAKING THEM BETTER CYBERSECURITY PROFESSIONALS. IN ADDITION TO COMPLETING RIGOROUS, REQUIRED COURSEWORK, THE SFS SCHOLARS WILL ENGAGE IN EXPERIENTIAL LEARNING THROUGH OPPORTUNITIES FOR INDIVIDUAL AND GROUP RESEARCH PROJECTS AND OTHER EXTRACURRICULAR ACTIVITIES, WHICH WILL PROVIDED DEEPLY TECHNICAL AS WELL AS INTERDISCIPLINARY LEARNING EXPERIENCES AND LEADERSHIP DEVELOPMENT TAILORED TO EACH STUDENT'S PREPARATION AND ASPIRATION. THIS PROJECT IS SUPPORTED BY THE CYBERCORPS(R) SCHOLARSHIP FOR SERVICE (SFS) PROGRAM, WHICH FUNDS PROPOSALS ESTABLISHING OR CONTINUING SCHOLARSHIP PROGRAMS IN CYBERSECURITY AND ALIGNS WITH THE U.S. NATIONAL CYBER STRATEGY TO DEVELOP A SUPERIOR CYBERSECURITY WORKFORCE. FOLLOWING GRADUATION, SCHOLARSHIP RECIPIENTS ARE REQUIRED TO WORK IN CYBERSECURITY FOR A FEDERAL, STATE, LOCAL, OR TRIBAL GOVERNMENT ORGANIZATION FOR THE SAME DURATION AS THEIR SCHOLARSHIP SUPPORT. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

SEX DIFFERENCES IN STRESS INOCULATION OF ADDICTION-LIKE PHENOTYPES

ASSESSING THE EFFECTIVENESS OF THE SECOND CHANCE ACT GRANT PROGRAM THROUGH A PHASED EVALUATION APPROACH USING AN IMPLEMENTATION SCIENCE MIXED METHODS APPROACH

DATA-DRIVEN SOLUTIONS FOR TEMPORAL, SPATIAL, AND SPATIOTEMPORAL DYNAMIC FUNCTIONAL CONNECTIVITY - PROJECT SUMMARY/ABSTRACT EXISTING APPROACHES TO ESTIMATE AND CHARACTERIZE WHOLE BRAIN TIME-VARYING CONNECTIVITY FROM FMRI DATA HAVE SHOWN CONSIDERABLE PROMISE, WITH EXPONENTIAL GROWTH IN RESEARCH IN THIS FIELD. WE AND OTHERS HAVE DEVELOPED A POWERFUL SET OF TOOLS THAT ARE NOW IN WIDE USE IN THE COMMUNITY. HOWEVER, THE IMPACT OF MENTAL ILLNESS ON BRAIN CONNECTIVITY IS COMPLEX, AND AS WE SHOW, LIMITATIONS IN EXISTING METHODS OFTEN RESULT IN MISSING IMPORTANT FEATURES ASSOCIATED WITH BRAIN DISORDERS (E.G. TRANSIENT FRACTIONATION OF THE SPATIAL STRUCTURE OF BRAIN NETWORKS). SOME OF THESE IMPORTANT LIMITATIONS INCLUDE 1) THE MOST WIDELY-USED APPROACHES OFTEN REQUIRE A NUMBER OF PRIOR AND LIMITING ASSUMPTIONS THAT ARE NOT WELL STUDIED, 2) METHODS OFTEN ASSUME LINEAR RELATIONSHIPS EITHER WITHIN OR BETWEEN NETWORKS OVER TIME, AND 3) METHODS ASSUME SPATIALLY FIXED NODES AND IGNORE THE POSSIBILITY OF SPATIALLY FLUID EVOLUTION OF NETWORKS OVER TIME. WE PROPOSE A NOVEL FAMILY OF MODELS THAT BUILDS ON THE WELL-STRUCTURED FRAMEWORK OF JOINT BLIND SOURCE SEPARATION TO CAPTURE A MORE COMPLETE CHARACTERIZATION OF (POTENTIALLY NONLINEAR) SPATIO-TEMPORAL DYNAMICS WHILE PROVIDING A WAY TO RELAX OTHER LIMITING ASSUMPTIONS. OUR MODELS WILL ALSO PRODUCE A RICH SET OF METRICS TO CHARACTERIZE THE AVAILABLE DYNAMICS AND ENABLE IN DEPTH COMPARISON WITH CURRENTLY AVAIL- ABLE MODELS INCLUDING THOSE THAT ARE MODEL BASED. WE WILL EXTENSIVELY VALIDATE OUR APPROACHES IN A VARIETY OF WAYS INCLUDING SIMULATIONS AND EVALUATION OF RIGOR AND ROBUSTNESS IN LARGE NORMATIVE DATA SETS. FINALLY, WE WILL APPLY THE DEVELOPED TOOLS TO STUDY THE IMPORTANT AREA OF DYNAMIC PROPERTIES IN MENTAL ILLNESSES INCLUDING SCHIZ- OPHRENIA, BIPOLAR DISORDER, AND THE AUTISM SPECTRUM. THERE IS CONSIDERABLE EVIDENCE OF DISRUPTION OF DYNAMICS IN ALL THREE DISORDERS, AND AS WE SHOW THE USE OF STATIC (OR EVEN EXITING DYNAMIC) APPROACHES CAN MISS IMPORTANT INFORMATION ABOUT BRAIN RELATED DIFFERENCES ASSOCIATED WITH EACH. WE WILL PROVIDE OPEN SOURCE TOOLS AND RELEASE DATA THROUGHOUT THE DURATION OF THE PROJECT VIA A WEB PORTAL AND THE NITRC REPOSITORY, HENCE ENABLING OTHER INVESTIGATORS TO USE OUR APPROACHES AND COMPARE THEIR OWN METHODS WITH OUR OWN. OUR TOOLS HAVE WIDE APPLI- CATION TO THE STUDY OF THE HEALTHY BRAIN AS WELL AS MANY OTHER DISEASES SUCH AS ALZHEIMER'S DISEASE AND ATTENTION DEFICIT HYPERACTIVITY DISORDER. 38

CRCNS: CYTOSKELETAL MECHANISMS OF DENDRITE ARBOR SHAPE DEVELOPMENT

MINDFULNESS-BASED SMOKING CESSATION ENHANCED WITH MOBILE TECHNOLOGY FOR LOW-INCOME SMOKERS

COMBINATIONAL REGULATION OF INFLAMMATION IN OTITIS MEDIA

INTESTINAL MICROBIOTA-MEDIATED ROTAVIRUS VACCINE FAILURE - PROJECT SUMMARY INFECTION OF GUT EPITHELIA BY ATTENUATED ROTAVIRUS (RV) VACCINES SERVES TO PROTECT MILLIONS OF LIVES ANNUALLY. IT IS INCREASINGLY APPRECIATED THAT GUT MICROBIOTA, WHICH SHAPE THE MILIEU IN WHICH ROTAVIRUSES ENCOUNTER THE EPITHELIUM IS A PIVOTAL DETERMINANT OF ROTAVIRUS VACCINE EFFICACY. INDEED, RV VACCINES HAVE PROVEN TO BE MUCH LESS EFFECTIVE IN DEVELOPING COUNTRIES WHICH ARE KNOWN TO HAVE STARK DIFFERENCES IN GUT MICROBIOTA COMPOSITION. OUR PUBLISHED WORK DEMONSTRATES THAT MICROBIOTA CAN BOTH DIRECTLY IMPACT RV AND, MOREOVER, IMPACT GUT EPITHELIA TO PREVENT AGAINST ITS ENTRY AND REPLICATION. FURTHERMORE, OUR UNPUBLISHED WORK COMPELLINGLY ARGUES FOR A CENTRAL ROLE FOR GUT MICROBIOTA COMPOSITION IN RV VACCINE INEFFICACY. SPECIFICALLY, WE FIND THAT TRANSPLANT OF MICROBIOTA FROM NON-RV VACCINE RESPONDING CHILDREN CONFERS A MICROBIOTA-DEPENDENT NON-RESPONDER PHENOTYPE. IN ADDITION, CULTURING INFANT FECAL SAMPLES IN BIOREACTOR CONTINUOUS CULTURE SYSTEMS YIELDS SUPERNATANTS THAT DIFFERENTIALLY INHIBIT RV VACCINE REPLICATION IN VITRO. HENCE, THE CENTRAL GOALS OF THIS PROPOSAL ARE TO IDENTIFY AND ISOLATE MICROBIOTA CONSTITUENTS THAT DRIVE RV VACCINE INEFFICACY IN HUMANS AND DETERMINE MECHANISMS BY WHICH THEY ACT. FINDINGS FROM THIS WORK WILL ADVANCE OUR FUNDAMENTAL KNOWLEDGE ON BACTERIAL-VIRAL INTERACTIONS IN THE GUT, MECHANISTICALLY ENLIGHTEN HOW MICROBIOTA CAN IMPACT REPLICATION AND RESPONSE TO LIVE, ATTENUATED ORAL VACCINES AND POTENTIALLY AID IN THE DEVELOPMENT OF NOVEL STRATEGIES TO REDUCE THE BURDEN OF ENTERIC VIRAL INFECTIONS.

RATIONAL DESIGN OF TRANSFERRIN BINDING PROTEIN-BASED VACCINES TO COMBAT GONORRHEA

SMOKERS' DECISION-MAKING ABOUT TOBACCO USE: THE INTERPLAY OF AFFECTIVE AND COGNITIVE FACTORS WITH PRODUCT CHARACTERISTICS

THE DEVELOPMENT OF JOINT ATTENTION AFTER INFANCY

TAS::89 0240::TAS RESEARCH SUPPORT TO BUILD AND TEST COMPONENTS OF THE PDC DESIGN, COLLECT DATA, WRITE REPORTS, MAKE DESIGN OBSERVATIONS

ALTERED CNS INTERCELLULAR SIGNALING MECHANISMS IN CARDIOVASCULAR DISEASE

PREPARING LEADERSHIP IN ADAPTED PHYSICAL EDUCATION THROUGH AN INTERUNIVERSITY COLLABORATORY

STATE ADMINISTRATIVE MATCHING GRANTS FOR SUPPLEMENTAL NUTRITION ASSISTANCE PROGRAM

DEVELOPING STEM PROFESSIONALS AS EDUCATORS AND TEACHER LEADERS

THE NATIONAL CENTER ON CHILD TRAFFICKING: INNOVATION AND DISSEMINATION OF EVIDENCE-BASED TRAUMA TREATMENT AND SERVICES FOR CHILDREN AND FAMILIES IMPACTED BY TRAFFICKING - .“THE NATIONAL CENTER ON CHILD TRAFFICKING: INNOVATION AND DISSEMINATION OF EVIDENCE-BASED TRAUMA TREATMENT AND SERVICES FOR CHILDREN AND FAMILIES IMPACTED BY TRAFFICKING” WILL ESTABLISH A NATIONAL NETWORK OF EXPERTS IN TRAUMA, TRAFFICKING, AND IMPLEMENTATION SCIENCE TO DEVELOP, ADAPT, DELIVER, AND DISSEMINATE PRODUCTS, RESOURCES, AND INTERVENTIONS TO IMPROVE OUTCOMES FOR YOUTH AND FAMILIES WHO HAVE EXPERIENCED COMMERCIAL SEXUAL EXPLOITATION AND TRAFFICKING (CSET). YOUTH WHO HAVE EXPERIENCED CSET HAVE VERY HIGH RATES OF TRAUMA EXPOSURE, INCLUDING EARLY TRAUMA (E.G. SEXUAL ABUSE, TRAUMATIC LOSS/ SEPARATION, FAMILY VIOLENCE) AS WELL AS TRAUMA WHILE BEING TRAFFICKED (E.G. PHYSICAL/SEXUAL VIOLENCE BY TRAFFICKERS/ PURCHASERS). THE CUMULATIVE IMPACT OF THESE TRAUMATIC EXPERIENCES LEADS TO HIGH RATES OF POST-TRAUMATIC STRESS, DEPRESSION, ANXIETY, SUBSTANCE USE, AND SELF-INJURY. CSET OCCURS TO YOUTH OF ALL AGES, GENDERS, AND RACES/ETHNICITIES; HOWEVER, YOUTH OF COLOR AND LGBTQ YOUTH ARE SIGNIFICANTLY OVER-REPRESENTED AND MALES ARE UNDERIDENTIFIED. THE NATIONAL CENTER ON CHILD TRAFFICKING (NCCT) WILL INCREASE AND IMPROVE ACCESS TO TRAUMA-FOCUSED EVIDENCE-BASED MENTAL TREATMENTS AND TRAUMA-INFORMED INTERVENTIONS GUIDED BY PRINCIPLES OF TRAUMA-INFORMED CARE TAILORED AND ADAPTED TO MEET THE NEEDS OF YOUTH WHO HAVE EXPERIENCED CSET, AS WELL AS INCREASE AND IMPROVE TRAUMA AND TRAFFICKING AWARENESS AND COLLABORATIVE MULTI-DISCIPLINARY CROSS-SECTOR RESPONSE. THE NCCT WILL (1) DEVELOP AND DISSEMINATE NATIONAL PRACTICE STANDARDS AND CONSENSUS GUIDELINES FOR MH TREATMENT CROSSCUTTING EBPS TO 1000 MENTAL HEALTH PROFESSIONALS AND WEBINAR TRAINING TO 4000 PROFESSIONALS, (2) DELIVER AND EVALUATE TRAINING OF TF-CBT FOR CSET TO 250 THERAPISTS IN 5 SAMHSA/HHS REGIONS, DEVELOP RESOURCES FOR THERAPISTS AND TRAINERS TO ENHANCE DISSEMINATION AND SERVICE DELIVERY, DISSEMINATE TO 1000 PROVIDERS, (3) DEVELOP AND DISSEMINATE STANDARDS, GUIDELINES, AND TRAINING ADDRESSING CO-OCCURRING TRAUMA AND SUBSTANCE USE PROBLEMS TO 1000 MENTAL HEALTH AND SUBSTANCE ABUSE PROFESSIONALS, WEBINAR TRAINING TO 1600 PROFESSIONALS, INTEGRATE THE GUIDELINES INTO AN EXISTING EVIDENCE-BASED TRAUMA AND SUBSTANCE USE TREATMENT, RISK REDUCTION THROUGH FAMILY THERAPY, AND TRAIN 50 THERAPISTS IN THE ADAPTED MODEL, (4) ADAPT AND DISSEMINATE TRAINING IN TRAUMA-INFORMED PARENTING, THE RESOURCE PARENT CURRICULUM, ADAPTED FOR YOUTH WHO HAVE EXPERIENCED CSET TO 100 RPC FACILITATORS, (5) ADAPT AND DISSEMINATE TRAINING IN TRAUMA-INFORMED RESIDENTIAL CARE, THINK TRAUMA. TO 50 THINK TRAUMA TRAINERS, AND TRAIN STAFF AT TARGETED CSET CONGREGATE CARE/RESIDENTIAL TREATMENT PLACEMENTS, (6) DEVELOP AND DISSEMINATE RESOURCES FOR MDT AND CSET SPECIALIST PROFESSIONALS, INCLUDING PRACTICE GUIDELINES AND TRAINING CURRICULA (FORECAST) INCORPORATING CSET RESPONSE TO 650 PROFESSIONALS, WEBINAR TRAINING TO 400 PROFESSIONALS, (7) DEVELOP SECONDARY TRAUMATIC STRESS/COMPASSION FATIGUE AWARENESS MATERIALS AND STRATEGIES AND DELIVER TRAINING IN THE PRACTICES TO 1000 PROFESSIONALS SERVING YOUTH WHO HAVE EXPERIENCED CSET. OVER 11,000 PEOPLE WILL BE IMPACTED BY THE PROJECT THROUGH RESOURCES DEVELOPED AND DISSEMINATED AND TRAININGS PROVIDED (1490 Y2, 2565 Y3, 2630 Y4, 5250 Y5).

THIS AWARD APPROVES FUNDING FOR THE 2023-24 VOLUNTEER GENERATION FUND PROGRAM DESCRIBED IN THE APPROVED PROGRAM NARRATIVE AND BUDGET. YOUR 2023-24 REGULATORY MATCH IS 20%, AND YOUR BUDGETARY MATCH IS 20%.

COMPARATIVE IMMUNOLOGY OF FILOVIRUS RESERVOIR ROUSETTUS AEGYPTIACUS

NOVEL NONLINEAR OPTICAL PROCESSES IN ACTIVE, RANDOM AND NANOSTRUCTURED SYSTEMS

FIRST IN THE WORLD - DEVELOPMENT

IMPROVING OUTCOMES OF GEORGIA'S CHILDREN AND FAMILIES AFFECTED BY SUBSTANCE ABUSE: STRENGTHENING THE PARTNERSHIP BETWEEN THE DEPARTMENT OF FAMILY AND CHILDREN SERVICES AND FAMILY TREATMENT COURTS

SNRK IN ISCHEMIC VASCULAR DISEASES

GEOSPATIAL FACTORS & IMPACTS: MEASUREMENT AND USE

SPECIAL EDUCATION RESEARCH GRANTS

CRCNS: MOLECULAR AND COMPUTATIONAL DISSECTION OF COLD NOCICEPTION

FUNCTIONAL ANALYSIS OF FLAVIVIRUS GENETIC RESISTANCE.

ASSESSMENT OF APPROACH-AVOIDANCE MOTIVATION IN NEUROPSYCHIATRIC DISORDERS - ABSTRACT PAR-18-30 “DEVELOPMENT AND OPTIMIZATION OF TASKS AND MEASURES FOR FUNCTIONAL DOMAINS OF BEHAVIOR” ENCOURAGES RESEARCH PROJECTS THAT WILL DEVELOP AND OPTIMIZE NEW OR EXISTING TASKS AND MEASURES FOR THE RESEARCH DOMAIN CRITERIA (RDOC). THIS CALL STEMS FROM WORKGROUPS OF THE NATIONAL ADVISORY MENTAL HEALTH COUNCIL THAT IDENTIFIED SIGNIFICANT GAPS IN THE RDOC MEASUREMENT TOOLKIT. IN THE NEGATIVE VALENCE SYSTEMS (NVS) DOMAIN, ONE PRIORITY AREA IS THE NEED FOR BEHAVIORAL PARADIGMS FOR IDENTIFYING AREAS OF OVERLAP AND DISTINCTION BETWEEN NVS, WHICH MOTIVATE DEFENSIVE AVOIDANCE BEHAVIORS, AND POSITIVE VALENCE SYSTEMS (PVS), WHICH MOTIVATE REWARD-APPROACH BEHAVIORS. WE CONTEND THAT APPROACH-AVOIDANCE (AP-AV) PARADIGMS OFFER A PROMISING SOLUTION. AP-AV TASKS ARE ESSENTIALLY BEHAVIORAL APPROACH TESTS THAT ENABLE ASSESSMENT OF OVERT BEHAVIORAL RESPONSES TO ACUTE THREATS. THE AIMS OF THIS PROPOSAL ARE TO DEMONSTRATE THE (1) PSYCHOMETRIC ADEQUACY (TEST-RETEST RELIABILITY) AND (2) DIAGNOSTIC/PREDICTIVE VALIDITY OF A USER-FRIENDLY INSTRUCTED AP-AV-TASK WE’VE DEVELOPED FOR ASSESSING PSYCHOSOCIAL DYSFUNCTION ASSOCIATED WITH ANXIETY, DEPRESSION, PSYCHOSIS, AND OTHER CONDITIONS. OUR AIMS BUILD UPON EXTENSIVE PRELIMINARY RESEARCH IN OUR LAB DEVOTED TO OPTIMIZING TASK PARAMETERS, MEASURES AND ADMINISTRATION. THIS WORK HAS THE POTENTIAL TO YIELD AN EASY-TO-USE AND WIDELY DISSEMINABLE AP-AV TASK FOR IDENTIFYING AREAS OF OVERLAP AND DISTINCTION BETWEEN NVS AND PVS, AS WELL AS A GENERAL AP-AV METHODOLOGY THAT IS ADAPTABLE FOR ASSESSING OVERT BEHAVIORAL RESPONSES TO ACUTE THREATS. TO ACHIEVE THESE AIMS, WE WILL RECRUIT THREE MATCHED GROUPS OF ADULTS (HEALTHY, ELEVATED SOCIAL ANXIETY, AND ELEVATED SOCIAL ANHEDONIA). INCLUSION OF GROUPS WITH ANXIETY AND ANHEDONIA ARE NECESSARY TO ASSESS DIAGNOSTIC AND PREDICTIVE VALIDITY. PARTICIPANTS WILL COMPLETE STANDARDIZED CLINICAL ASSESSMENTS AND COMPLETE THE INSTRUCTED AP-AV TASK MULTIPLE TIMES DURING TWO NEUROIMAGING SESSIONS, SEPARATED BY 10-14 DAYS. BETWEEN IMAGING SESSIONS, ECOLOGICAL MOMENTARY ASSESSMENTS (EMA) WILL CAPTURE MOOD, MOTIVATIONAL LEVEL, FREQUENCY OF REAL-LIFE APPROACH/AVOIDANCE, AND EMOTIONAL REGULATION STRATEGY USE. THIS RESEARCH IS THEORETICALLY SIGNIFICANT BECAUSE IT HIGHLIGHTS THE RELEVANCE OF THEORIES OF AP-AV MOTIVATION FOR RESEARCH DEVOTED TO IDENTIFYING AREAS OF OVERLAP AND DISTINCTION BETWEEN NVS AND PVS. THIS RESEARCH IS METHODOLOGICALLY INNOVATIVE BECAUSE IT WILL PRODUCE A USER-FRIENDLY AP-AV TASK WITH STRONG PSYCHOMETRIC PROPERTIES FOR USE IN BEHAVIORAL (STAND-ALONE) OR NEUROIMAGING RESEARCH. OUTCOME DATA WILL ALSO PROVIDE THE NECESSARY EMPIRICAL FOUNDATION FOR FUTURE INVESTIGATIONS INTO THE SUITABILITY OF AP-AV TASKS FOR USE WITH INDIVIDUALS WHO VARY WIDELY IN AGE, ABILITY, AND/OR SEVERITY OF DISORDER.

DEVELOPMENT OF INNOVATIVE THERAPEUTICS FOR OTITIS MEDIA

EVALUATION AND OPTIMIZATION OF A JUST-IN-TIME MESSAGING INTERVENTION TO REDUCE ALCOHOL-FACILITATED INTIMATE PARTNER VIOLENCE PERPETRATION AMONG AT-RISK YOUNG ADULT MEN AND WOMEN - PROJECT SUMMARY YOUNG ADULT MEN AND WOMEN PERPETRATE INTIMATE PARTNER VIOLENCE (IPV) AT HIGH RATES. A SUMMARY OF OVER 30 YEARS OF RESEARCH CONCLUDES THAT ALCOHOL IS A CAUSAL FACTOR OF IPV, PARTICULARLY ACUTE ALCOHOL INTOXICATION, HIGHLIGHTING THE CRITICAL NEED FOR INTERVENTIONS DELIVERED PROXIMALLY TO DRINKING EPISODES – A PERIOD OF INCREASED RISK FOR IPV. YET DESPITE THE HIGH SOCIETAL AND PERSONAL COSTS ASSOCIATED WITH HEAVY DRINKING AND IPV AND THE HIGH PREVALENCE OF ALCOHOL FACILITATED IPV, EMPIRICALLY SUPPORTED INTERVENTIONS ARE LACKING, PARTICULARLY THOSE THAT ARE LOW RESOURCE AND EASILY SCALABLE FOR WIDE DISSEMINATION. IT IS INCREASINGLY FEASIBLE TO DELIVER JUST-IN- TIME (JIT) INTERVENTIONS VIA MOBILE TECHNOLOGY, PARTICULARLY THOSE THAT ADAPT OVER TIME TO AN INDIVIDUAL'S CHANGING NEEDS TO PROVIDE APPROPRIATE INTERVENTION STRATEGIES BASED ON REAL TIME, REAL WORLD CONTEXT – JUST-IN- TIME ADAPTIVE INTERVENTIONS (JITAIS). JITAIS HAVE BEEN EVALUATED FOR A RANGE OF BEHAVIORAL HEALTH ISSUES INCLUDING ALCOHOL USE; HOWEVER, NO EMPIRICALLY SUPPORTED JITAIS FOR ALCOHOL-FACILITATED IPV PERPETRATION EXIST. TO DEVELOP JITAIS, JIT INTERVENTIONS ARE OPTIMIZED THROUGH INNOVATIVE MICRO-RANDOMIZED TRIALS (MRTS) IN WHICH INDIVIDUALS ARE MICRO-RANDOMIZED TO RECEIVE DIFFERENT INTERVENTION STRATEGIES AT CRITICAL TIME POINTS TO DETERMINE WHEN A MESSAGE IS BEST DELIVERED, WHICH TYPE OF MESSAGE IS MOST IMPACTFUL FOR WHOM, AND UNDER WHAT CONDITIONS. THUS, THE PRESENT APPLICATION WILL COMBINE A TRADITIONAL RCT TO EVALUATE THE EFFICACY OF DELIVERING JIT MESSAGES TO REDUCE ALCOHOL FACILITATED IPV PERPETRATION WITH A MRT TO OPTIMIZE THE SELECTION AND ADAPTATION OF MESSAGES FOR A FUTURE JITAI. THE PROPOSED INTERVENTION FOCUSES ON THEORETICALLY AND EMPIRICALLY SUPPORTED TARGETS FOR IPV PERPETRATION CONSISTENT WITH THE I3 MODEL – THE PREVAILING UNIFYING THEORY OF IPV PERPETRATION – INCLUDING DISTRESS TOLERANCE SKILLS, EMOTION REGULATION SKILLS, AND ALCOHOL REDUCTION STRATEGIES. AN RCT BY THE PI (K08AA021745) SUPPORTS THESE INTERVENTION TARGETS FOR REDUCING ALCOHOL USE AND IPV PERPETRATION AMONG WOMEN WITH SEXUAL ASSAULT HISTORIES, AND A RECENT PILOT STUDY SUPPORTS THE FEASIBILITY AND ACCEPTABILITY OF DELIVERING THESE JIT MESSAGES USING A MRT DESIGN TO AT-RISK MEN AND WOMEN WITH GOOD EFFECTS OF THE INTERVENTION ON KEY ALCOHOL AND IPV OUTCOMES. AS SUCH, WE PROPOSE TO EVALUATE THE EFFICACY OF THIS JIT MESSAGING INTERVENTION IN 400 HEAVY DRINKING YOUNG ADULTS WITH RECENT IPV PERPETRATION. PARTICIPANTS WILL BE RANDOMIZED TO THE JIT MESSAGING INTERVENTION OR AN ASSESSMENT ONLY CONTROL (RCT DESIGN). ALL PARTICIPANTS WILL COMPLETE A BASELINE SURVEY, 30-DAYS OF TWICE DAILY MONITORING, AND 1-, 3-, AND 6-MONTH FOLLOW- UP SURVEYS. WITHIN THE INTERVENTION ARM (MRT DESIGN), INDIVIDUALS WILL BE MICRO-RANDOMIZED AFTER EACH MORNING AND EVENING REPORT DURING THE 30 DAYS OF MONITORING TO (1) RECEIVE A JIT MESSAGE OR NOT, AND (2) IF YES, TO ONE OF THREE MESSAGE TYPES (DISTRESS TOLERANCE SKILL, ER SKILL, ALCOHOL REDUCTION STRATEGY). THIS INNOVATIVE DESIGN WILL OPTIMIZE THE SELECTION AND ADAPTATION OF JIT MESSAGES FOR A FUTURE JITAI TO REDUCE ALCOHOL FACILITATED IPV.

LINKING WATERSHED RESEARCH AND GK-12 EDUCATION WITHIN AN ECOSYSTEM CONTEXT

IMPROVING THE HEALTH OF PEOPLE WITH INTELLECTUAL/DEVELOPMENTAL DISABILITIES AND MOBILITY LIMITATIONS IN GEORGIA - NEARLY 28% OF ADULTS LIVING IN GEORGIA HAVE SOME TYPE OF DISABILITY. GEORGIANS WITH INTELLECTUAL ANDDEVELOPMENTAL DISABILITIES (IDD) AND THOSE WITH MOBILITY LIMITATIONS (ML) EXPERIENCE PROFOUND HEALTHDISPARITIES COMPARED TO ADULTS WITHOUT DISABILITIES. THEY ARE MORE LIKELY TO REPORT HAVING POOR OR FAIR HEALTH,EXPERIENCE A DISPROPORTIONATE BURDEN OF PREVENTABLE CHRONIC CONDITIONS, AND REPORT SIGNIFICANTLY MOREMENTALLY UNHEALTHY DAYS COMPARED TO ADULTS WITHOUT DISABILITIES. THESE DISPARITIES ARE INFLUENCED BY ANUMBER OF POLICY, SYSTEM, AND ENVIRONMENTAL FACTORS, INCLUDING LACK OF ACCESS TO ADEQUATELY TRAINEDHEALTHCARE PROVIDERS AND FINANCIAL BARRIERS TO RECEIVING CARE. DESPITE INCREASING EFFORTS TO ADDRESS DISABILITYHEALTH DISPARITIES AT THE NATIONAL LEVEL, COORDINATED AND CONTEXT-SPECIFIC EFFORTS TO REDUCE HEALTHINEQUITIES FOR PEOPLE WITH DISABILITIES LIVING IN GEORGIA HAVE NOT BEEN REALIZED.IN THIS APPLICATION, THE CENTER FOR LEADERSHIP IN DISABILITY AT GEORGIA STATE UNIVERSITY DESCRIBES ACOMPREHENSIVE PLAN TO REDUCE HEALTH DISPARITIES AMONG ADULTS WITH IDD AND ADULTS WITH ML INGEORGIA. THROUGH A COOPERATIVE AGREEMENT WITH THE CENTERS FOR DISEASE CONTROL AND PREVENTION, NATIONALCENTER ON BIRTH DEFECTS AND DEVELOPMENTAL DISABILITIES, WE PROPOSE TO:1) ESTABLISH, EXPAND, AND ENHANCE PARTNERSHIPS WITH STATEWIDE AND NATIONAL PARTNERS;2) CONDUCT NEEDS ASSESSMENTS TO IDENTIFY GAPS IN ACCESSIBLE PREVENTIVE HEALTH CARE AND HEALTHPROMOTION SERVICES AVAILABLE TO ADULTS WITH IDD AND ADULTS WITH ML;3) ADMINISTER AND EVALUATE A TRAINING FOR HEALTHCARE PROVIDERS ON ACCESSIBLE HEALTH CARE;4) IMPLEMENT AND EVALUATE A DEMONSTRATION PROJECT TO LINK ADULTS WITH IDD TO ACCESSIBLE PREVENTIVEHEALTH CARE AND HEALTH PROMOTION PROGRAMS IN THEIR COMMUNITIES;5) IMPLEMENT AND EVALUATE EVIDENCE-BASED HEALTH PROMOTION INTERVENTIONS AND POLICY, SYSTEMS, ANDENVIRONMENTAL CHANGES; AND6) DISSEMINATE KEY FINDINGS AND LESSONS LEARNED.SEVERAL OF THE STRATEGIES DESCRIBED ABOVE WILL B E DESIGNED IN PARTNERSHIP WITH OTHER STATE DISABILITY ANDHEALTH PROGRAMS AND IMPLEMENTED WITH A NUMBER OF GEORGIA COLLABORATORS. WE WILL SCALE THESE STRATEGIESAND ACTIVITIES STATEWIDE USING A PHASED IMPLEMENTATION APPROACH TO FACILITATE CONTINUOUS PROGRAMQUALITY IMPROVEMENT AND SUPPORT PROGRAM SUSTAINABILITY.EXPECTED OUTCOMES TO BE ACHIEVED DURING THE PERIOD OF PERFORMANCE INCLUDE STRENGTHENEDENGAGEMENT WITH STATE AND NATIONAL PARTNERS; INCREASED KNOWLEDGE OF DISPARITIES AND NEEDS AT THESTATEWIDE AND HEALTH DISTRICT LEVELS; INCREASED COMPETENCY AMONG HEALTHCARE PROVIDERS TO SERVE ADULTS WITHIDD AND ADULTS WITH ML; INCREASED KNOWLEDGE AMONG ADULTS WITH IDD ABOUT PREVENTIVE HEALTHCARE ANDHEALTH BEHAVIORS, AND BARRIERS TO RECEIVING HEALTH CARE AND ENGAGING IN HEALTH BEHAVIORS; INCREASEDENGAGEMENT IN HEALTH PROMOTION PROGRAMS AMONG ADULTS WITH IDD AND ADULTS WITH ML; INCREASED POLICY,SYSTEM, AND ENVIRONMENTAL CHANGES IMPLEMENTED AT THE STATE AND HEALTH DISTRICT LEVELS; AND INCREASEDKNOWLEDGE AMONG HEALTH PROFESSIONALS AND POLICYMAKERS ABOUT WAYS TO IMPROVE DISABILITY HEALTH EQUITY.BEYOND THE PERIOD OF PERFORMANCE, IMPLEMENTING AND EVALUATING OUR PROPOSED PLAN WILL RESULT IN ANINCREASED NUMBER OF PROVIDERS THAT CAN OFFER ACCESSIBLE PREVENTIVE HEALTH CARE, AND FEWER UNMETPREVENTIVE HEALTH CARE NEEDS, IMPROVED HEALTH BEHAVIORS, AND REDUCED PREVALENCE OF CHRONIC CONDITIONSAND RISK FACTORS AMONG ADULTS WITH IDD AND ADULTS WITH ML IN OUR STATE. THE PROPOSED PROJECT WILL CONTRIBUTETOWARD ADVANCING HEALTH EQUITY FOR PEOPLE WITH DISABILITIES IN GEORGIA AND THROUGHOUT THE NATION.

TAS::89 0222::TAS; NEW; DEVELOPMENT OF A SUITE OF ENGINEERED MULTI-SPOKE SUPERCONDUCTING CAVITIES FOR NUCLEAR PHYSICS, LIGHT SOURCES AND DRIVEN SYSTE

A DECENTRALIZED MACRO AND MICRO GENE-BY-ENVIRONMENT INTERACTION ANALYSIS OF SUBSTANCE USE BEHAVIOR AND ITS BRAIN BIOMARKERS

UNIVERSITY CENTERS FOR EXCELLENCE IN DEVELOPMENTAL DISABILITIES

PROXIMAL EFFECTS OF ALCOHOL ON SAME-SEX INTIMATE PARTNER VIOLENCE

INVESTIGATION OF NEW SUPERCONDUCTING MATERIALS FOR THE NEXT GENERATION HIGH-GRADIENT TRF CATITIVES FOR PARTICLE ACCELEARATORS

EARLY-STAGE PRECLINICAL VALIDATION OF CARBON MONOXIDE PRODRUGS FOR ACUTE KIDNEY INJURY - IN RESPONSE TO PAR-19-294 (EARLY-STAGE PRECLINICAL VALIDATION OF THERAPEUTIC LEADS FOR DISEASES OF INTEREST TO THE NIDDK), WE PROPOSE TO CONDUCT PRECLINICAL VALIDATION OF CARBON MONOXIDE (CO) AS A THERAPEUTIC AGENT FOR TREATING ACUTE KIDNEY INJURY (AKI), WHICH AFFLICTS A LARGE NUMBER OF PATIENTS WITH SERIOUS AND SOMETIMES FATAL CONSEQUENCES. CURRENTLY, THERE ARE NO TREATMENT OPTIONS AVAILABLE OTHER THAN MAINTENANCE THERAPY. THEREFORE, DEVELOPING DISEASE MODIFYING TREATMENT FOR AKI WILL ADDRESS AN IMPORTANT, UNMET MEDICAL NEED. THE PROPOSED WORK OF DEVELOPING CO-BASED THERAPEUTICS IS BASED ON CO’S ENDOGENOUS SIGNALING ROLES, THE AVAILABILITY OF A LARGE AMOUNT OF LITERATURE EVIDENCE TO SHOW CO’S CYTO- AND ORGAN-PROTECTIVE EFFECTS, OUR UNIQUE CHEMISTRY WORK TO PACK “CO IN A PILL” THROUGH INNOVATIVE PRODRUG DESIGN FOR EASY DELIVERY THROUGH PHARMACEUTICALLY ACCEPTABLE FORMS, AND OUR OWN EXTENSIVE PRELIMINARY RESULTS IN DEMONSTRATING THE ORGAN-PROTECTIVE EFFECTS OF SUCH CO PRODRUGS IN ANIMAL MODELS OF KIDNEY ISCHEMIA REPERFUSION INJURY AND RHABDOMYOLYSIS INJURIES, LIVER INJURY, SYSTEMIC INFLAMMATION, AND GI INFLAMMATION SUCH AS THE COLON AND STOMACH, AMONG OTHERS. IN THIS APPLICATION, WE PROPOSE TO EXAMINE SOME KEY PRECLINICAL VALIDATION ISSUES AND AIM TO PRODUCE ONE OR MORE LEAD COMPOUNDS READY FOR IND-ENABLING WORK BY THE END OF THE GRANT PERIOD. A VERY IMPORTANT ASPECT IS OUR PLAN TO USE MULTIPLE ANIMAL MODELS INCLUDING THE EXAMINATION IN LARGE ANIMALS SUCH AS PIG TO CONDUCT THE PHARMACOLOGICAL ASSESSMENT, WHICH SHOULD GIVE ENHANCED CHANCE OF SUCCESS WHEN TRANSLATING INTO HUMAN. SPECIFICALLY, WE PROPOSE TO PURSUE THE FOLLOWING SPECIFIC AIMS (1) DESIGN, SYNTHESIS, AND ASSESSMENT OF CO PRODRUGS, (2) THERAPEUTIC VALIDATION OF CO PRODRUG EFFICACY IN MOUSE MODELS OF AKI, AND (3) THERAPEUTIC VALIDATION OF CO PRODRUGS IN PIG MODELS OF AKI. THE PROPOSED WORK WILL BRIDGE THE GAP BETWEEN OUR LONG-TERM GOAL OF DEVELOPING CO-BASED THERAPEUTICS AND THE NEED FOR PRECLINICAL ASSESSMENTS. UPON COMPLETION OF THE PROJECT, WE WILL HAVE DEVELOPED AND FULLY VALIDATED THE EFFICACY OF A SERIES OF INNOVATIVE CO PRODRUGS THAT CAN EITHER DELIVER CO SYSTEMICALLY OR SELECTIVELY TARGET THE KIDNEY AND ALLOW FOR RENAL ENRICHMENT. FURTHER, WE WILL ALSO HAVE DEVELOPED A PIPELINE FOR BACKUP CANDIDATES. COLLECTIVELY, THE PROPOSED WORK WILL BE A MAJOR STEP IN DEVELOPING CO-BASED THERAPEUTICS AGAINST AKI AND OTHER FORMS OF ORGAN INJURY.

ROLE OF CD98 IN INTESTINAL PERMEABILITY

COLLABORATIVE RESEARCH: CHEMISTRY COALITIONS, WORKSHOPS AND COMMUNITIES OF SCHOLARS

DESIGNING MAGNETIC RESONANCE PROTEIN-BASED CONTRAST AGENTS WITH HIGH RELAXIVITY

HDAC1 AS A NUTRIENT SENSOR IN THE DEVELOPMENT AND PROGRESSION OF NAFLD - NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD) IS A GROWING METABOLIC DISORDER THAT IS CLOSELY ASSOCIATED WITH OBESITY AND INSULIN RESISTANCE/TYPE 2 DIABETES. NAFLD BEGINS WITH A SIMPLE HEPATIC STEATOSIS, WHICH IN SOME INDIVIDUALS MAY PROGRESS TO NONALCOHOLIC STEATOHEPATITIS (NASH), AN ADVANCED ABNORMITY THAT MAY FURTHER LEAD TO FIBROSIS, CIRRHOSIS, LIVER FAILURE OR CANCER. WHEREAS ENHANCED DE NOVO LIPOGENESIS AND FATTY ACID INFLUX INITIATE THE HEPATIC STEATOSIS, HEPATIC INFLAMMATION TRIGGERS THE TRANSITION FROM HEPATIC STEATOSIS TO NASH AND IS AN IMPORTANT DRIVING FORCE OF THE PATHOLOGICAL PROGRESSION TOWARDS FIBROGENESIS. HOWEVER, THE EXACT MECHANISMS UNDERLYING THE DEVELOPMENT AND PROGRESSION OF NAFLD REMAIN POORLY UNDERSTOOD. WHILE NUMEROUS STUDIES HAVE BEEN DEVOTED TO THE EVALUATION OF GENETIC FACTORS INVOLVED IN OBESITY AND ITS ASSOCIATED COMPLICATIONS SUCH AS NAFLD, MUCH IS UNKNOWN ABOUT EPIGENETIC CHANGES IN THIS PROCESS. EPIGENETIC REGULATION, INCLUDING HISTONE ACETYLATION, IS A MOLECULAR LINK BETWEEN ENVIRONMENTAL FACTORS (E.G., DIETS) AND COMPLEX DISEASES (E.G., NAFLD). HISTONE DEACETYLASE 1 (HDAC1) ACTS TO REMOVE ACETYL GROUPS FROM LYSINE RESIDUES IN HISTONES, THEREBY INHIBITING GENE EXPRESSION. OUR PRELIMINARY DATA SUGGESTED THAT LIVER-SPECIFIC DELETION OF HDAC1 DECREASED HEPATIC LIPID ACCUMULATION, INFLAMMATION AND FIBROSIS IN MICE. THEREFORE, WE HYPOTHESIZE THAT HDAC1 PLAYS A CENTRAL ROLE IN THE DEVELOPMENT OF NAFLD. AIM 1 WILL DETERMINE THE ROLE OF HDAC1 IN PROMOTING HEPATIC STEATOSIS. WE HAVE GENERATED GENETIC MODELS WITH LIVER SPECIFIC DELETION OR OVEREXPRESSION OF HDAC1. WE WILL DETERMINE: 1) WHETHER AND HOW LIVER-SPECIFIC DELETION OF HDAC1 PREVENTS, WHEREAS SPECIFIC OVEREXPRESSION OF HDAC1 PROMOTES HEPATIC STEATOSIS IN MICE; 2) WHETHER DOWN-REGULATION OF THE TRANSCRIPTIONAL REPRESSOR KLF3 MEDIATES THE EFFECT OF HDAC1 IN PROMOTING HEPATIC LIPID STORAGE VIA REGULATION OF PPAR. AIM 2 WILL DETERMINE THE ROLE OF HDAC1 IN PROMOTING HEPATIC INFLAMMATION IN THE DEVELOPMENT OF NASH. HEPATIC INFLAMMATION TRIGGERS THE TRANSITION FROM HEPATIC STEATOSIS TO NASH. WE WILL DETERMINE: 1) WHETHER LIVER-SPECIFIC DELETION OF HDAC1 PREVENTS, WHEREAS SPECIFIC OVEREXPRESSION OF HDAC1 PROMOTES NASH IN MICE; 2) WHETHER DOWN-REGULATION OF THE TRANSCRIPTIONAL REPRESSOR KLF3 MEDIATES THE EFFECT OF HDAC1 IN PROMOTING HEPATIC CHEMOTAXIS AND INFLAMMATION VIA REGULATION OF C-JUN. AIM 3 WILL DETERMINE THE MECHANISM UNDERLYING REGULATION OF HDAC1 BY EXCESS NUTRIENTS. O-GLCNACYLATION HAS EMERGED AS A KEY NUTRIENT SENSOR THAT REGULATES CELLULAR METABOLIC PATHWAYS IN RESPONSE TO OVER-NUTRITIONAL CUES. WE WILL DETERMINE WHETHER HDAC1 O-GLCNACYLATION BY EXCESS NUTRIENTS SUCH AS GLUCOSE AND SATURATED FATTY ACIDS, LEVELS OF WHICH ARE COMMONLY ELEVATED IN OBESITY, INCREASES HDAC1 PROTEIN STABILITY BY PREVENTING UBIQUITINATION AND PROTEASOMAL DEGRADATION, LEADING TO ENHANCED HDAC1 PROTEIN CONTENT AND ACTIVITY. THIS PROJECT WILL DEFINE THE ROLE OF HDAC1 AS A NUTRIENT SENSOR THAT REGULATES HEPATIC LIPID METABOLISM AND INFLAMMATION IN THE DEVELOPMENT AND PROGRESSION OF NFALD. OUR STUDIES COULD GUIDE THE DEVELOPMENT OF THE EPIGENETIC REGULATION AS NEW THERAPEUTIC TARGETS IN THE TREATMENT OF NAFLD.

NOVEL THERAPEUTICS AGAINST RESPIRATORY SYNCYTIAL VIRUS INFECTION

UNIVERSITY CENTERS FOR EXCELLENCE IN DEVELOPMENTAL DISABILITIES

SEX-DEPENDENT REGULATION OF SOCIAL REWARD BY OXYTOCIN IN THE MESOLIMBIC REWARD CIRCUITRY - PROJECT SUMMARY THE REWARDING PROPERTIES OF SOCIAL INTERACTIONS ARE CRITICAL TO THE EXPRESSION OF ADAPTIVE SOCIAL BEHAVIOR AND TO THE DEVELOPMENT AND MAINTENANCE OF SOCIAL RELATIONSHIPS. LITTLE IS KNOWN, HOWEVER, ABOUT THE FACTORS THAT DETERMINE THE REWARD VALUE OF SOCIAL INTERACTIONS OR ABOUT THE BASIC NEURAL MECHANISMS THAT UNDERLIE SOCIAL REWARD, PARTICULARLY IN FEMALES. WE DO KNOW THAT THE MESOLIMBIC DOPAMINE SYSTEM (MDS) IS CENTRAL TO THE NEURAL CIRCUITRY CONTROLLING THE REWARDING PROPERTIES OF MANY OTHER STIMULI SUCH AS DRUGS OF ABUSE. A PRIMARY COMPONENT OF THE MDS IS DOPAMINE (DA)-CONTAINING NEURONS IN THE VENTRAL TEGMENTAL AREA (VTA) THAT PROJECT TO THE NUCLEUS ACCUMBENS (NAC) AS WELL AS TO OTHER SITES SUCH AS THE MEDIAL PREFRONTAL CORTEX. CRITICAL INPUTS TO THE MDS INCLUDE OXYTOCIN (OT)-CONTAINING PROJECTIONS FROM THE HYPOTHALAMUS. WE AND OTHERS HAVE DEMONSTRATED THAT, IN MALE RODENTS, ACTIVATION OF OT RECEPTORS IN THE CAUDAL VTA AND IN THE NAC IS ESSENTIAL FOR THE REWARDING PROPERTIES OF SOCIAL INTERACTION. REMARKABLY, DESPITE THE CONSIDERABLE EVIDENCE FOR SEX DIFFERENCES IN OT REGULATION OF SOCIAL BEHAVIORS, THE ROLE OF OT IN REGULATING SOCIAL REWARD IN FEMALES HAS NOT BEEN INVESTIGATED. THIS PROJECT WILL PROVIDE SUBSTANTIAL NEW INFORMATION ON THE FACTORS THAT DETERMINE THE REWARD VALUE OF SOCIAL INTERACTIONS AND ON THE NEURAL MECHANISMS THAT MEDIATE SOCIAL REWARD BY TESTING THIS SERIES OF INTEGRATED HYPOTHESES IN MALE AND FEMALE SYRIAN HAMSTERS. BASED ON PUBLISHED AND PRELIMINARY DATA FROM OUR LAB AND OTHERS, WE HAVE HYPOTHESIZED THAT: 1) THERE IS AN INVERTED U RELATIONSHIP BETWEEN THE “DOSE” OF SOCIAL INTERACTIONS AND SOCIAL REWARD, 2) THIS DOSE-RESPONSE RELATIONSHIP IS INITIATED AT LOWER DOSES IN FEMALES THAN IN MALES, AND 3) THIS SEX DIFFERENCE IS MEDIATED BY DIFFERENTIAL OT-INDUCED DA RELEASE IN THE MDS. THIS PROJECT HAS SUBSTANTIAL POTENTIAL FOR TRANSLATION TO CLINICALLY-RELATED PROBLEMS BY PROVIDING: 1) NEW INFORMATION ON HOW SOCIAL STIMULI CAN TRANSITION FROM BEING REWARDING TO BEING LESS REWARDING OR EVEN AVERSIVE, 2) POTENTIAL MECHANISMS FOR UNDERSTANDING WELL-KNOWN SEX DIFFERENCES IN THE INCIDENCE OF NEUROPSYCHIATRIC AND NEURODEVELOPMENTAL DISORDERS FOR WHICH DYSFUNCTIONAL SOCIAL RELATIONSHIPS ARE AN IMPORTANT SYMPTOM, AND 3) THE POTENTIAL FOR DEVELOPMENT OF GENDER- SPECIFIC TREATMENTS FOR THESE DISORDERS.

UNIFIED MULTIVARIATE DATA-DRIVEN SOLUTIONS FOR STATIC AND DYNAMIC BRAIN CONNECTIVITY

DEVELOPMENT OF A NOVEL STRATEGY TO PRODUCE ANTIBACTERIAL GLYCOCONJUGATE VACCINES

CENTER FOR LEADERSHIP IN DISABILITY AT GEORGIA STATE UNIVERSITY

ADVANCING UNDERSTANDING OF RACISM-RELATED HEALTH DISPARITIES BEGINNING BEFORE BIRTH: A MULTISITE STUDY WITH BLACK AND LATINA PREGNANT WOMEN - DESCRIPTIVE TITLE: ADVANCING UNDERSTANDING OF RACISM-RELATED HEALTH DISPARITIES BEFORE BIRTH PROJECT SUMMARY/ABSTRACT RACIAL AND ETHNIC INJUSTICE ARE PREVALENT AND DEVASTATING CAUSES OF STRESS AND SUBSEQUENT HEALTH DISPARITIES. BLACK AND LATINA WOMEN EXPERIENCE A HIGHER BURDEN OF PREGNANCY COMPLICATIONS, MATERNAL MORTALITY, AND PRETERM BIRTH COMPARED TO WHITE WOMEN. THESE DISPARITIES IN BIRTH OUTCOMES ARE EXACERBATED BY SYSTEMS OF CARE THAT NEGLECT OR INVALIDATE THE EXPERIENCES OF PREGNANT WOMEN OF COLOR, CONTRIBUTING TO HIGH-RISK DELIVERIES, UNNECESSARY OBSTETRIC INTERVENTIONS, AND DEATH OF WOMEN AND INFANTS. YET, NO STUDIES HAVE EXAMINED WHETHER EXPERIENCES OF RACISM PRENATALLY AFFECT FETAL HEALTH AND DEVELOPMENT THROUGH A PROCESS OF “BIOLOGICAL EMBEDDING” OF RACISM MEASURED DAILY DURING PREGNANCY. THIS STUDY WILL ADDRESS THREE MAJOR GAPS IN THE LITERATURE TO DATE. FIRST, EXPERIENCES OF RACISM AND DISCRIMINATION ARE OFTEN MEASURED GLOBALLY, MISSING THE CUMULATIVE NATURE OF STRESS EXPOSURE ON FETAL PHYSIOLOGICAL DEVELOPMENT. SECOND, IT IS UNCLEAR WHETHER SPECIFIC PARTNER BEHAVIORS (E.G., VALIDATION OF RACISM-RELATED EXPERIENCES) AND/OR CULTURALLY-GROUNDED COPING STRATEGIES GROUNDED IN THE RADICAL HEALING FRAMEWORK (E.G., RACIAL/ETHNIC IDENTITY, ACTIVISM) CAN BUFFER EFFECTS OF RACISM ON MATERNAL PHYSIOLOGY, FETAL PHYSIOLOGY, AND BIRTH OUTCOMES. THIRD, GIVEN THE NOVELTY OF THIS RESEARCH PROGRAM, IT IS IMPORTANT TO INTEGRATE QUALITATIVE METHODS THAT CENTER THE EXPERIENCES OF BLACK AND LATINA WOMEN DURING THIS TRANSFORMATIVE AND VULNERABLE LIFE STAGE. THE OBJECTIVE OF THIS PROPOSAL IS TO ADVANCE UNDERSTANDING OF RACISM-RELATED HEALTH DISPARITIES IN PREGNANT WOMEN AND INFANTS BY (1) ENROLLING BLACK AND LATINA WOMEN DURING THE 2ND AND 3RD TRIMESTER OF PREGNANCY AND ASSESSING DAILY RACISM EXPERIENCES THROUGH DAILY DIARY ASSESSMENTS (14 CONSECUTIVE DAYS TRIMESTER); (2) MEASURING MATERNAL AND FETAL PSYCHOPHYSIOLOGY DURING THE THIRD TRIMESTER (E.G., HEART RATE, HEART RATE VARIABILITY); (3) ASSESSING NEWBORN NEURODEVELOPMENT WITHIN 48 HOURS OF BIRTH; AND (4) EXPLORING CULTURALLY-GROUNDED BUFFERS AND QUALITATIVE EXPERIENCES OF RACISM ON WOMEN AND INFANTS. WE WILL ENROLL 400 PREGNANT WOMEN FROM THE ATLANTA, GA AND SALT LAKE CITY, UT METRO AREAS (N=200/SITE), USING ESTABLISHED PROTOCOLS FOR RECRUITING AND RETAINING WOMEN DURING THIS DEVELOPMENTAL STAGE. PARTICIPATING WOMEN WILL COMPLETE QUESTIONNAIRES AND A 2-WEEK DAILY DIARY OF STRESSORS RELATED TO RACISM IN THE 2ND AND 3RD TRIMESTER. IN THE 3RD TRIMESTER, WOMEN WILL COMPLETE THESE MEASURES, A QUALITATIVE INTERVIEW, AND TWO WEEKS OF IN-HOME MATERNAL AND FETAL PHYSIOLOGICAL MEASURES, WHICH INCLUDES AN INNOVATIVE MEASURE OF FETAL HEART RATE (HR) AND HR VARIABILITY (HRV). WOMEN WILL ALSO COMPLETE A STRUCTURED INTERACTION TASK WITH THEIR ROMANTIC PARTNER OR CLOSEST SUPPORT PERSON; INVOLVING DISCUSSIONS OF HOW EACH COPE WITH RACISM-RELATED STRESSORS. WITHIN 48 HOURS OF BIRTH, INFANTS WILL COMPLETE THE NICU NETWORK NEUROBEHAVIORAL SCALE (NNNS) TO ASSESS HOW PRENATAL EXPOSURE TO RACISM MAY AFFECT NEWBORN BIRTH OUTCOMES. THIS SHORT-TERM LONGITUDINAL STUDY LAYS THE FOUNDATION FOR FURTHER FOLLOW-UP OF INFANTS AND WOMEN INTO EARLY CHILDHOOD AND A PROGRAMMATIC LINE OF RESEARCH DEVOTED TO UNDERSTANDING AND INTERVENING WITH MARGINALIZED MOTHERS AND CHILDREN TO REDUCE THE EFFECTS OF RACISM ON FAMILY HEALTH AND WELLBEING.

INVERSE NEUROVASCULAR COUPLING IN THE HYPOTHALAMUS AND ITS ROLE IN POSITIVE FEEDBACK REGULATION OF VASOPRESSIN NEURONS IN HEALTH AND DISEASE - NEUROVASCULAR COUPLING (NVC) LINKS INCREASES IN NEURONAL ACTIVITY WITH A RAPID AND SPATIALLY RESTRICTED INCREASE IN LOCAL BLOOD FLOW. KNOWLEDGE ON THE CELLULAR MECHANISMS DRIVING NVC HAS BEEN FOCUSED ON TRANSIENT EXTEROCEPTIVE SENSORY STIMULATION AND LIMITED TO SUPERFICIAL DORSAL BRAIN AREAS (CORTEX). THUS, LESS IS UNDERSTOOD ON NVC DYNAMICS OF DEEPER BRAIN REGIONS, WHICH CAN BE ACTIVATED BY SLOW, SUSTAINED, AND WIDESPREAD STIMULI (E.G., PHYSIOLOGICAL DISTURBANCES OF BODILY HOMEOSTASIS). DERANGEMENT IN HOMEOSTATIC PROCESSES IS A KEY DRIVER OF PATHOLOGICAL MECHANISMS IN PREVALENT DISEASES SUCH AS NEUROHUMORAL ACTIVATION IN HEART FAILURE (HF). TO ADDRESS THIS CRITICAL GAP IN OUR KNOWLEDGE, WE DEVELOPED A NOVEL EXPERIMENTAL APPROACH THAT ENABLES INTEROCEPTIVE-INDUCED NVC DURING A CHALLENGE TO BODILY HOMEOSTASIS. OUR PRELIMINARY DATA SHOW THAT CONTRARY TO THE CANONICAL NVC RESPONSE, A SYSTEMIC AND PHYSIOLOGICAL HOMEOSTATIC CHALLENGE (ACUTE SALT-LOADING) PROGRESSIVELY INCREASED VASOPRESSIN (VP) NEURONAL FIRING, EVOKED ACTIVITY-DEPENDENT VASOCONSTRICTION AND DECREASED LOCAL BLOOD FLOW IN THE HYPOTHALAMIC SUPRAOPTIC NUCLEUS (SON). THE SALT-INDUCED INVERSE NVC (INVC) RESPONSE WAS SLOW, SUSTAINED AND WIDESPREAD, AND MEDIATED BY THE DENDRITIC RELEASE OF VP WITHIN THE SON. INVC RESULTED IN LOCAL TISSUE HYPOXIA, WHICH EVOKED FURTHER EXCITATION OF VP NEURONS. BASED ON THESE OBSERVATIONS, WE HYPOTHESIZE THAT INVC IS A PHYSIOLOGICAL PROCESS THAT CONTRIBUTES TO POSITIVE FEEDBACK MODULATION OF THE VP NEURONAL POPULATION SO THAT THE PHYSIOLOGICAL DISTURBANCE CAN BE EFFICIENTLY CORRECTED. STILL, THE PRECISE SIGNALING MECHANISMS AND CELLULAR TARGETS MEDIATING THIS NOVEL PHYSIOLOGICAL MODALITY OF NVC, AND MORE IMPORTANTLY, WHETHER AN ABERRANT INVC RESPONSE CONTRIBUTES TO EXACERBATED VP NEURONAL ACTIVITY CHARACTERISTIC OF PREVALENT CARDIOMETABOLIC DISEASES, SUCH AS HF, REMAINS UNKNOWN. USING A MULTIDISCIPLINARY APPROACH, IN AIM 1 WE WILL ELUCIDATE THE PRECISE SIGNALING MECHANISMS AND CELLULAR TARGETS MEDIATING ACTIVITY- DEPENDENT INVC IN THE SON (NEURON-TO-VESSEL SIGNALING). IN AIM 2, WE WILL DETERMINE THE MECHANISMS AND TARGETS BY WHICH THE INVC EVOKES THE POSITIVE FEEDBACK MODULATION OF VP NEURONAL FIRING ACTIVITY (VASCULO-TO- NEURON SIGNALING). FINALLY, IN AIM3, WE WILL ELUCIDATE MECHANISMS CONTRIBUTING TO EXACERBATED INVC-MEDIATED POSITIVE FEEDBACK REGULATION OF VP NEURONS IN A DISEASE STATE (HF). BOTH IN VIVO AND EX VIVO NOVEL APPROACHES (2-PHOTON IMAGING, PATCH-CLAMP ELECTROPHYSIOLOGY, AND EX VIVO CANNULATION OF SON ARTERIOLES) WILL BE USED IN NOVEL TRANSGENIC RAT MODELS THAT ENABLE VISUALIZATION (EGFP) AND MANIPULATION (OPTO- AND CHEMOGENETICALLY) OF VP NEURONS IN THE SON. THE ACTIVATION OF ACID-SENSING ION CHANNELS (ASIC) AND MODULATION OF ASTROCYTE GLUTAMATE TRANSPORTERS WILL BE INVESTIGATED AS KEY MOLECULAR TARGETS. WE EXPECT RESULTS FROM THIS WORK TO CONTRIBUTE TO A BETTER UNDERSTANDING OF FUNDAMENTAL MECHANISMS UNDERLYING NVC RESPONSES IN DIFFERENT BRAIN REGIONS AND UNDER DIFFERENT ACTIVITY-DEPENDENT MODALITIES. MOREOVER, WE ANTICIPATE OUR STUDIES TO UNVEIL NOVEL PATHOLOGICAL MECHANISMS AND THERAPEUTIC TARGETS FOR THE TREATMENT OF HIGHLY PREVALENT CARDIOMETABOLIC DISEASES. 1

SEASONAL AND UNIVERSAL VACCINATION IN AGED POPULATIONS WITH PRE-EXISTING IMMUNITY - PROJECT SUMMARY CURRENT INFLUENZA (FLU) VACCINATION BASED ON HYPERVARIABLE HEMAGGLUTININ (HA) PROTEIN FAILS TO PROVIDE EFFECTIVE CROSS PROTECTION. THE EFFICACY OF VACCINATION IS LOW IN THE AGED POPULATIONS EVEN WITH PRE-EXISTING IMMUNITY. THE IMPACTS OF PRE-EXISTING IMMUNITY ON THE IMMUNOGENICITY AND EFFICACY OF UNIVERSAL AND SEASONAL VACCINATION LARGELY REMAIN NOT WELL UNDERSTOOD IN THE AGED POPULATIONS. DEVELOPMENT OF NEW FLU VACCINES AND VACCINATION STRATEGIES IMPROVING CROSS PROTECTIVE EFFICACY IN YOUNG NAÏVE AND AGED HOSTS WITH PRE-EXISTING IMMUNITY IS OF HIGH PRIORITY. MONO CONSERVED ANTIGENIC TARGETS INDUCING CROSS PROTECTION TESTED IN NAÏVE ANIMAL MODELS INCLUDE THE FLU A VIRUS M2 EXTRACELLULAR DOMAIN (M2E), HA-STALK DOMAINS, AND NEURAMINIDASE (NA) WERE REPORTED BUT INSUFFICIENT FOR TRANSLATION TO HUMANS. THE MULTI-TARGET UNIVERSAL VACCINES IN NAÏVE AND AGED HOSTS WITH PRE-EXISTING IMMUNITY REMAIN TO BE DEVELOPED. WE DEVELOPED HETEROLOGOUS TANDEM REPEAT OF M2E (5XM2E) PRESENTED ON IMMUNOGENIC VIRUS-LIKE PARTICLES (5XM2E VLP). VACCINATION WITH 5XM2E VLP WAS EFFECTIVE IN BROADENING CROSS PROTECTION BUT SUBOPTIMAL. A FURTHER IMPROVED UNIVERSAL VACCINE SHOULD BE DEVELOPED. OUR PRELIMINARY STUDIES FOUND SYNERGISTIC EFFECTS ON IMPROVING CROSS PROTECTION BY BOTH M2E AND NA IMMUNITY. THEREFORE, AS A NEW UNIVERSAL VACCINE CANDIDATE, WE DEVELOPED A MULTI NA + 5XM2E VLP VACCINE CONTAINING MULTI-SUBTYPE NA AND 5XM2E ON THE SAME VLP PARTICLE. IN ADDITION, WE NEWLY DESIGNED GENETICALLY LINKED NOVEL RECOMBINANT M2E-STALK UNIVERSAL PROTEIN VACCINES EFFECTIVELY INDUCING BOTH M2E AND HA-STALK IMMUNITY AND CONFERRING BROAD CROSS- GROUP PROTECTION. ADJUVANTED UNIVERSAL VACCINATION WILL OVERCOME THE AGING-RELATED IMMUNE SENESCENCE BY ACTIVATING T AND B IMMUNE CELLS IN NAÏVE HOSTS OR AGED POPULATIONS UNDER PRE-EXISTING IMMUNITY. IN THIS PROJECT, WE WILL TEST THE HYPOTHESIS THAT NEW UNIVERSAL VACCINATION INDUCING MULTI IMMUNITY (M2E, STALK, NA) WILL ENHANCE THE BREADTH AND EFFICACY OF CROSS PROTECTION IN ADULT AND AGED POPULATIONS WITH OR WITHOUT PRE-EXISTING IMMUNITY. UNDER AIM 1, WE WILL DETERMINE THE EFFICACY OF MULTI-TARGET UNIVERSAL VACCINES IN YOUNG ADULT MICE AND FERRETS UNDER NAÏVE AND PRE-EXISTING IMMUNE CONDITIONS. IN AIM 2 STUDIES, WE WILL DETERMINE THE DURABILITY OF CROSS PROTECTIVE IMMUNITY BY MULTI TARGETING NEW UNIVERSAL VACCINES AND TEST A VACCINATION STRATEGY ENHANCING CROSS PROTECTION IN AGED MOUSE AND FERRET ANIMAL MODELS. IN THE AIM 3, WE WILL INVESTIGATE CROSS PROTECTIVE IMMUNE MECHANISMS OF MULTI TARGETING UNIVERSAL VACCINATION IN YOUNG AND AGED MOUSE MODELS. THE OUTCOMES IN THIS PROJECT WILL BE HIGHLY SIGNIFICANT IN THE ASPECT OF TRANSLATIONAL SCIENCE AND RELEVANCE TO IMPROVE THE CROSS PROTECTIVE EFFICACY OF FLU VACCINATION.

GEORGIA STATE PHYSICAL ACTIVITY AND NUTRITION PROGRAM (G-SPAN) - THOUGH SIGNIFICANT INVESTMENTS AND PROGRESS HAVE BEEN MADE IN NUTRITION AND PHYSICAL ACTIVITY, HEALTH DISPARITIES PERSIST IN OBESITY PREVALENCE, CHRONIC DISEASE PREVALENCE, PHYSICAL FITNESS, FOOD AND NUTRITION SECURITY, BREASTFEEDING PREVALENCE, AND EARLY CARE AND EDUCATION ACROSS GEORGIA. THIS PROPOSAL DETAILS A PLAN TO EXPAND EXISTING INITIATIVES AND ESTABLISH NEW POLICY, SYSTEMS AND ENVIRONMENTAL (PSE) STRATEGIES AND ACTIVITIES IN THE STATE OF GEORGIA THAT WILL IMPROVE THE CAPACITY OF STATE, REGIONAL, AND LOCAL AGENCIES TO ADDRESS THESE DISPARITIES EFFECTIVELY. THE PLAN STRATEGIES FOCUS ON NUTRITION, PHYSICAL ACTIVITY, BREASTFEEDING, AND EARLY CARE EDUCATION OBESITY PREVENTION/FARM TO EARLY CARE. SPECIFICALLY, THIS PROPOSAL SEEKS TO ADDRESS INEQUITIES IN EACH OF THESE AREAS WITHIN PRIORITY POPULATIONS IN SELECT GEOGRAPHIC REGIONS OF GEORGIA. BY BRINGING TOGETHER VARIOUS STATE AND LOCAL PARTNERS, INCLUDING THE VOICE OF COMMUNITIES IMPACTED BY THESE DISPARITIES, THIS PROPOSAL WILL STRENGTHEN EXISTING PARTNERSHIPS AND EXPAND THEIR CAPACITY TO ACHIEVE IMPROVED HEALTH OUTCOMES. WITH EXTENSIVE EXPERIENCE IN SUPPORTING STATE LEVEL PSE CHANGE, PROGRAM DEVELOPMENT AND COLLECTIVE IMPACT EVALUATION, THE GEORGIA HEALTH POLICY CENTER (GHPC) LOCATED AT 55 PARK PLACE NE, 8TH FLOOR, ATLANTA, GA 30303, WILL ACT AS THE BACKBONE ORGANIZATION FOR THIS COOPERATIVE AGREEMENT. IN CLOSE PARTNERSHIP WITH STATE AND LOCAL AGENCIES, SUCH AS THE GEORGIA DEPARTMENTS OF PUBLIC HEALTH (GDPH) AND EARLY CARE AND LEARNING (DECAL), WHOLESOME WAVE GEORGIA, GA CHAPTER-AMERICAN ACADEMY OF PEDIATRICS/GA BREASTFEEDING COALITION, HEALTHMPOWERS, AND CHILDREN’S HEALTHCARE OF ATLANTA/STRONG4LIFE, WE SEEK TO IMPROVE OUTCOMES IN EACH OF THE 4 STRATEGY AREAS. EXAMPLES OF THESE OUTCOMES INCLUDE: NUTRITION OUTCOMES - INCREASED NUMBER OF YOUTH/CHILD-SERVING AND COMMUNITY-BASED OUT OF SCHOOL TIME SETTINGS THAT ADOPT NUTRITION GUIDELINES TO SUPPORT INCREASED ACCESS TO HEALTHIER FOODS - INCREASED UPTAKE AND EXPANSION OF GEORGIA FRESH FOR LESS VOUCHER REDEMPTION - INCREASED NUMBER OF HEALTH SYSTEMS AND HEALTH CLINICS THAT ADOPT PRODUCE PRESCRIPTION PROGRAMS PHYSICAL ACTIVITY OUTCOMES - INCREASED POLICIES, PLANS, OR COMMUNITY DESIGN CHANGES THAT INCREASE ACCESS TO PA - BUILT ENVIRONMENT INTERVENTION APPROACHES ADOPTED THAT CONNECT ACTIVITY-FRIENDLY ROUTES TO EVERYDAY DESTINATIONS TO INCREASE PA - INDIVIDUALS AND COMMUNITIES ENROLLED IN ACTIVE PEOPLE, HEALTHY NATIONSM INITIATIVE BREASTFEEDING OUTCOMES - INCREASED ACCESS TO PROGRAMS THAT PROVIDE CONTINUITY OF CARE FOR BF FAMILIES - REGIONAL BF COALITIONS AND CADRE OF BF CHAMPIONS ESTABLISHED WHO COALESCE AROUND A COMMON AGENDA, STATE PLAN CREATION, AND COLLABORATE ON INTEGRATED AND REINFORCING ACTIVITIES ACROSS REGIONS - REPLICATE EXISTING PATHWAY 2 ACADEMIC PROGRAM FOR PRE-SERVICE HUMAN LACTATION PROFESSIONALS AT 1 HBCU AND 1 UNIVERSITY TO PREPARE IBCLCS EARLY CARE EDUCATION OUTCOMES - INCREASED STATE LEVEL ECE POLICIES AND ACTIVITIES THAT IMPROVE NUTRITION, PA, BR AND FARM TO ECE INCLUDING ESTABLISHED QRIS STANDARDS AND MEASURES FOR EACH STRATEGIES - GEORGIA FTECE PROVIDER NETWORK ESTABLISHED AS A HUB FOR CHILD CARE PROVIDERS TO ACCESS FTECE RELATED RESOURCES, TRAINING OPPORTUNITIES, AND TA SUPPORT - IMPROVED KNOWLEDGE AND ADOPTION OF FTECE STRATEGIES IN ECE SITES IN TARGET GEOGRAPHIC REGIONS & COMPLETION OF GFTECE STRATEGIC PLAN OBJECTIVES STATEWIDE BEYOND THE 4 STRATEGY AREAS OUTLINED, THIS PROPOSAL WILL ALSO SEEK TO IMPROVE THE CAPACITY AND ABILITY OF PARTNERS IN TARGET REGIONS OF GA IMPLICATED BY HEALTH INEQUITIES TO ADOPT PSE CHANGE THROUGH REGIONAL CAPACITY BUILDING GRANTS. A COLLECTIVE IMPACT EVALUATION FRAMEWORK WILL BE EMPLOYED TO UNDERSTAND CONTEXTS AND MECHANISMS THAT SUPPORT REGIONAL PSE AND BEHAVIOR CHANGE. QUALITY IMPROVEMENT WILL BE FACILITATED VIA A COMMUNITY-LED MONITORING LEARNING AND ADAPTATION (CLM) FRAMEWORK TO SUPPORT MODIFICATIONS TO PSE STRATEGIES AND ACTION PLANS TO ACHIEVE IDENTIFIED OUTCOMES.

EDUCATIONAL OPPORTUNITY CENTERS PROGRAM

UPWARD BOUND PROGRAM

GRADUATE PSYCHOLOGY EDUCATION PROGRAMS