Mso Inc

EXPANDS MARKETS FOR CLIMATE-SMART PEANUTS, LEAFY GREENS, BEEF AND FOREST PRODUCTS IN SC AND SUPPORTS FARMER AND FORESTER IMPLEMENTATION AND MONITORING OF CLIMATE-SMART PRACTICES.

HEAD START AND EARLY HEAD START

HEAD START - FULL YEAR CENTER BASED OPTION

TAS::89 0331::TAS RECOVERY RECOVERY ACT: CLEMSON UNIVERSITY WIND TURBINE DRIVETRAIN TEST FACILITY

HEAD START AND EARLY HEAD START

CLEMSON UNIVERSITY HEERF-INSTITUTIONAL

THIS COOPERATIVE AGREEMENT IS FOR THE VIRTUAL PROTOTYPING OF GROUND SYSTEMS.

CARES ACT: HIGHER EDUCATION EMERGENCY RELIEF FUND - CLEMSON UNIVERSITY

SC COBRE FOR TRANSLATIONAL RESEARCH IMPROVING MUSCULOSKELETAL HEALTH (SC-TRIMH)

HEALTH CENTER CLUSTER

CENTER OF BIOMATERIALS FOR TISSUE REGENERATION (CBTR)

RII TRACK-1: AI-ENABLED DEVICES FOR THE ADVANCEMENT OF PERSONALIZED AND TRANSFORMATIVE HEALTHCARE IN SOUTH CAROLINA -THE VISION OF THE ARTIFICIAL INTELLIGENCE-ENABLED DEVICES FOR THE ADVANCEMENT OF PERSONALIZED AND TRANSFORMATIVE HEALTHCARE IN SOUTH CAROLINA (ADAPT) PROJECT IS TO BUILD RESEARCH CAPACITY AT THE NEXUS OF ARTIFICIAL INTELLIGENCE (AI), LIFE AND SOCIAL SCIENCES, AND BIOENGINEERING THROUGH FUNDAMENTAL RESEARCH, EDUCATION, WORKFORCE DEVELOPMENT, AND INDUSTRY PARTNERSHIPS. BUILDING THIS CAPACITY WILL SIGNIFICANTLY ACCELERATE THE DEVELOPMENT AND DEPLOYMENT OF AI SOLUTIONS TO CREATE NEXT-GENERATION BIOMEDICAL DEVICES THAT WILL IMPROVE HEALTHCARE OUTCOMES AND ADDRESS THE HEALTHCARE NEEDS OF SOUTH CAROLINIANS, ESPECIALLY THOSE IN UNDERSERVED REGIONS. ADAPT WILL CONTRIBUTE TO SOUTH CAROLINA?S AI-ENABLED BIOMEDICAL DEVICE INDUSTRY BY FOSTERING CROSS-CUTTING STEM RESEARCH THROUGHOUT THE STATE AND TRANSLATING RESEARCH OUTCOMES INTO NEW TECHNOLOGIES. PARTICIPATION IN AI DEVELOPMENT AND ASSOCIATED BIOMEDICAL DEVICE RESEARCH WILL BE EXPANDED BY RECRUITING AND SUPPORTING TRAINEES FROM GROUPS TRADITIONALLY UNDERREPRESENTED THROUGH STEM CAMPS, TEACHER ENGAGEMENT, AND RETENTION/PERSISTENCE INITIATIVES ALONG THE STEM PIPELINE. ADAPT WILL BE LED BY CLEMSON UNIVERSITY IN PARTNERSHIP WITH BENEDICT COLLEGE, THE CITADEL, CLAFLIN UNIVERSITY, COLLEGE OF CHARLESTON, FRANCIS MARION UNIVERSITY, MEDICAL UNIVERSITY OF SOUTH CAROLINA, SOUTH CAROLINA RESEARCH AUTHORITY, SOUTH CAROLINA STATE UNIVERSITY, TRI-COUNTY TECHNICAL COLLEGE, UNIVERSITY OF SOUTH CAROLINA, AND WINTHROP UNIVERSITY. ADAPT RESEARCH WILL FOCUS ON EMERGING BIOMEDICAL AI AND ITS INTEGRATION WITH TARGETED BIOMEDICAL DEVICES FOR USE IN THREE PHASES OF MEDICAL INTERVENTIONS: DIAGNOSIS, TREATMENT, AND REHABILITATION. THE AI-ENABLING CORE WILL TAKE ON FUNDAMENTAL RESEARCH IN BIOMEDICAL AI, TACKLING ISSUES SUCH AS DATA ACQUISITION, MULTIMODAL DATA FUSION, DATA REPRESENTATION LEARNING, META-LEARNING, PHYSICS-INFORMED MACHINE LEARNING, SECURITY, AND TRUSTWORTHY AI TO PROVIDE INTEGRATED SOLUTIONS FOR THE BIOMEDICAL DEVICES DEVELOPED IN EACH RESEARCH THRUST. THE AI ETHICS TEAM IN ADAPT?S AI-ENABLING CORE IS TASKED TO SET AI ETHICS STANDARDS AND DESIGN INNOVATIVE EDUCATION AND TRAINING PROGRAMS TO ENSURE THAT THE AI-ENABLED BIOMEDICAL DEVICES ARE TRUSTED BY BOTH HEALTHCARE PROVIDERS AND RECEIVERS IN PRACTICE. RESEARCH WILL ADDRESS CRITICAL ISSUES IN BIOMEDICAL AI, INCLUDING INCORPORATION OF ETHICS INTO DESIGN DECISIONS; ELIMINATION OF THE ?BLACK BOX? VIA EXPLAINABLE AI; INTEGRATION OF MULTIMODAL DATA VIA DEEP LEARNING MODELS; AND AI-DEVICE INTEGRATION VIA DIGITAL TWINS. ADAPT WILL DELIVER A NEW NATIONAL MODEL FOR DEVELOPING BIOMEDICAL DEVICES, EDUCATING AND TRAINING A BIOMEDICAL AI WORKFORCE, AND INTERACTING WITH STAKEHOLDERS. ADAPT WILL BENEFIT THE STATE OF SOUTH CAROLINA THROUGH: (1) LEADERSHIP AND NATIONAL PROMINENCE IN HEALTHCARE AI; (2) AN AI-LITERACY CAMPAIGN TO PROMOTE THE USE OF AI IN ADDRESSING HEALTHCARE DISPARITIES; (3) SOCIAL AWARENESS OF THE IMPORTANCE OF AI IN PRECISION MEDICINE; AND (4) PROFESSIONAL COMPETENCY IN AI THROUGH CONTINUING EDUCATION CREDITS FOR HEALTHCARE PROFESSIONALS (E.G., NURSES, PHYSICIANS, AND HEALTHCARE ADMINISTRATORS). THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

THIS INVESTMENT IS PART OF SOUTH CAROLINA?S SC NEXUS FOR ADVANCED RESILIENT ENERGY TECH HUBS. THIS PROJECT UPGRADES CLEMSON'S EXISTING SHARED-USE GRID EMULATION FACILITY (E-GRID) TO ACCELERATE THE MATURATION AND DEPLOYMENT OF DISTRIBUTED ENERGY RESOURCES AND OTHER SMART GRID TECHNOLOGIES THROUGH LIFE CYCLE AND COMPLIANCE TESTING IN REAL-LIFE CONDITIONS. CLEMSON WILL ALSO DEVELOP NEW OPTIMIZATION TECHNIQUES, CONTROL ALGORITHMS, SAFETY PROTOCOLS, AND MICRO-GRID MANAGEMENT STRATEGIES FOR A CYBERSECURE AND RELIABLE GRID AND CREATE NEW HANDS-ON TRAINING AND WORKFORCE DEVELOPMENT OPPORTUNITIES THAT ADDRESS GRID INTEGRATION CHALLENGES.

HEAD START AND EARLY HEAD START

UNIVERSITY TRANSPORTATION CENTERS

COBRE IN HUMAN GENETICS - SUMMARY COMMON AND RARE GENETIC DISEASES AFFECT A LARGE FRACTION OF THE WORLD’S POPULATION. ELUCIDATING THE MECHANISMS BY WHICH NATURALLY OCCURRING GENETIC VARIANTS AFFECT DISEASE RISK REQUIRES MULTIDISCIPLINARY EXPERTISE IN QUANTITATIVE, POPULATION, MOLECULAR, CELLULAR AND DEVELOPMENTAL GENETICS; STATISTICS, BIOINFORMATICS AND COMPUTATIONAL BIOLOGY; AND FUNCTIONAL GENOMICS IN CELL CULTURE AND ANIMAL MODELS. WE PROPOSE A CENTER OF BIOMEDICAL RESEARCH EXCELLENCE (COBRE) IN HUMAN GENETICS THAT CONSTITUTES A UNIQUE PARTNERSHIP BETWEEN THE CLEMSON UNIVERSITY CENTER FOR HUMAN GENETICS AND THE GREENWOOD GENETIC CENTER. RESEARCH IN THE COBRE IN HUMAN GENETICS WILL FOCUS ON UNDERSTANDING THE GENETIC, GENOMIC, AND EPIGENETIC MECHANISMS BY WHICH MOLECULAR GENETIC VARIATION AFFECTS RARE AND COMMON DISEASES. THE COBRE IN HUMAN GENETICS WILL SUPPORT FOUR RESEARCH PROJECTS FROM JUNIOR INVESTIGATORS THAT TACKLE SEVERAL OF THE OUTSTANDING CHALLENGES FACING MODERN HUMAN GENETICS, INCLUDING THE ROLES OF HUMAN LONG NON-CODING RNAS IN RISK FOR HUMAN DISEASE, THE EFFECTS OF STRUCTURAL VARIATION ON DISEASE PHENOTYPES AND GENE REGULATION, DEVELOPMENT OF ANIMAL MODELS FOR RARE DISEASES, AND INCORPORATING CONTEXT-DEPENDENT EFFECTS INTO STATISTICAL MODELS PREDICTING COMPLEX TRAIT PHENOTYPES FROM LARGE SCALE GENETIC VARIATION DATA. EIGHT PILOT PROJECTS LED BY JUNIOR INVESTIGATORS WILL CONTRIBUTE ADDITIONAL BREADTH AND DEPTH OF RESEARCH TOPICS TO THE COBRE IN HUMAN GENETICS. THE RESEARCH PROJECT LEADERS WILL BE MENTORED BY ESTABLISHED EXTERNAL NIH-FUNDED RESEARCHERS AS WELL AS THE THREE PIS. THE RESEARCH AND PILOT PROJECT LEADERS WILL BE SUPPORTED BY AN ADMINISTRATIVE CORE THAT PROVIDES A WIDE RANGE OF PROFESSIONAL DEVELOPMENT ACTIVITIES. THE COBRE IN HUMAN GENETICS WILL ESTABLISH BOTH INTERNAL AND EXTERNAL ADVISORY COMMITTEES AND IMPLEMENT A COMPREHENSIVE EVALUATION PLAN. THE PROJECTS WILL BE SUPPORTED BY A STATE-OF-THE-ART GENOMICS AND BIOINFORMATICS RESEARCH CORE THAT WILL BENEFIT TWO OTHER CLEMSON UNIVERSITY COBRES AS WELL AS OTHER FACULTY AT CLEMSON UNIVERSITY AND THE GREENWOOD GENETIC CENTER. THE COBRE IN HUMAN GENETICS HAS STRONG INSTITUTIONAL SUPPORT, WITH COMMITMENTS TO HIRE ADDITIONAL FACULTY TO EXPAND THE SCOPE OF THE RESEARCH ACTIVITIES DURING THIS PERIOD OF SUPPORT, AND TO PROVIDE GRADUATE STUDENT RESEARCH ASSISTANTSHIPS TO SUPPORT THE RESEARCH PROJECTS. THE RESEARCH PERFORMED BY THE PROJECT LEADERS OF THE COBRE IN HUMAN GENETICS WILL PROVIDE NEW KNOWLEDGE OF THE MECHANISMS BY WHICH MOLECULAR GENETIC VARIATION AFFECTS VARIATION IN COMPLEX TRAITS IN HEALTH AND DISEASE, ENHANCE THE NATIONAL REPUTATION OF CLEMSON UNIVERSITY AS A RESEARCH AND TRAINING CENTER IN HUMAN GENETICS, AND SET THE STAGE FOR FUTURE DEVELOPMENT OF INSTITUTIONAL TRAINING GRANTS AND PROGRAM PROJECTS. THIS COBRE WILL STRENGTHEN THE BIOMEDICAL RESEARCH INFRASTRUCTURE OF CLEMSON UNIVERSITY AND INCREASE THE NUMBER OF NIH-FUNDED SCIENTISTS IN THE STATE OF SOUTH CAROLINA.

DISEASE MODELING AND ANALYTICS TO INFORM OUTBREAK PREPAREDNESS, RESPONSE, INTERVENTION, MITIGATION, AND ELIMINATION IN SOUTH CAROLINA (DMA-PRIME)

COBRE:EUKARYOTIC PATHOGENS INNOVATION CENTER (EPIC)

** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** FRESHWATER SCARCITY IS A THREAT TO AGRICULTURAL PRODUCTION. IN MANY FRESHWATER-SCARCE REGIONS, SALINE WATER SOURCES CAN BE USED FOR IRRIGATION; HOWEVER, INCREASED SOIL SALINIZATION CONSTRAINS THEIR USE. WE CAN GROW SALT-TOLERANT CROPS SUSTAINABLY WITH APPROPRIATE DESALINATION TECHNIQUES AND EFFECTIVE MANAGEMENT WATER USE, NUTRIENT APPLICATION, AND SALINITY. WE WILL DEVELOP AN INTEGRATED HYDROPONIC CONTROLLED ENVIRONMENT AGRICULTURE (CEA) PLATFORM WITH PRE-BREEDING AND SCREENING OF MUSTARD GREENS, CUCUMBER, AND TOMATO GERMPLASM FOR SALT TOLERANCE AND TECHNOLOGIES FOR DESALINATION TO PROVIDE TAILORED-QUALITY IRRIGATION WATER. WE WILL INCLUDE UNIVERSITY AND K-12 EDUCATION ACTIVITIES AS WELL AS EXTENSION TRAINING AND OUTREACH OF STAKEHOLDERS. MAJOR IMPACT OF THIS PROJECT WILL BE INCREASED AND SUSTAINABLE USE OF NATURALLY OCCURRING SALINE WATER IN FOOD CROP PRODUCTION WITHOUT SALINIZING SOILS. SALT-TOLERANT MUSTARD GREENS, CUCUMBER, AND TOMATO VARIETIES WILL BE AVAILABLE FOR FURTHER IMPROVEMENT AND COMMERCIAL PRODUCTION.

COBRE: EUKARYOTIC PATHOGENS INNOVATION CENTER (EPIC) - PROJECT SUMMARY/ABSTRACT EUKARYOTIC PATHOGENS ARE THE CAUSATIVE AGENTS OF SOME OF THE MOST DEVASTATING AND INTRACTABLE DISEASES OF HUMANS, INCLUDING MALARIA, AMEBIC DYSENTERY, AFRICAN SLEEPING SICKNESS, CHAGAS DISEASE, TRICHOMONIASIS, ASPERGILLOSIS, CRYPTOCOCCAL FUNGAL MENINGITIS, TOXOPLASMOSIS AND PRIMARY AMEBIC MENINGOENCEPHALITIS (PAM). THE GLOBAL IMPACT OF THESE DISEASES IS IMMENSE. IT IS NOTEWORTHY THAT MANY OF THESE PATHOGENS ARE THE CAUSATIVE AGENTS OF NEGLECTED TROPICAL DISEASES (NTDS), NEGLECTED DISEASES OF POVERTY (NDPS) AND/OR ARE CLASSIFIED AS BIOTERRORISM AGENTS. IMPORTANTLY, INFECTIONS CAUSED BY EUKARYOTIC PATHOGENS ARE INCREASING IN THE US DUE TO GLOBALIZATION. THE PRIMARY GOAL OF THIS COBRE PROPOSAL IS TO INCREASE THE NUMBER OF NIH-FUNDED SCIENTISTS IN THE STATE OF SOUTH CAROLINA BY SUPPORTING A WORLD-CLASS RESEARCH CENTER, THE EUKARYOTIC PATHOGENS INNOVATION CENTER (EPIC), AT CLEMSON UNIVERSITY (CU). THE SCIENTIFIC FOCUS OF EPIC IS A MULTIDISCIPLINARY STUDY OF IMPORTANT GLOBAL EUKARYOTIC PATHOGENS. EPIC IS THE FIRST-AND-ONLY IN THE STATE WITH A FOCUS ON INFECTIOUS DISEASES, AND THE FIRST- AND-ONLY IN THE COUNTRY WITH A FOCUS ON EUKARYOTIC PATHOGENS. FOUR PROJECTS FROM TARGET JUNIOR INVESTIGATORS WILL BE SUPPORTED. THEIR PROJECTS ARE 1) REGULATION MECHANISMS OF TRYPANOSOME BRUCEI AXONEMAL DYNEIN, 2) FUNCTIONAL ROLES OF NCRNA, AFU-182, IN AZOLE RESPONSE AND PATHOBIOLOGY OF ASPERGILLUS FUMIGATUS, 3) INVESTIGATING THE FUNCTION OF MACROPHAGES IN THE EFFICACY OF ANTI-FUNGAL DRUGS IN LARVAL ZEBRAFISH, AND 4) EVALUATING ANTI-PARASITIC DIAZACYCLOBUTENES. THESE INVESTIGATORS WILL BE MATCHED WITH EXTERNAL AND INTERNAL MENTORS WHO ARE ESTABLISHED NIH-FUNDED RESEARCHERS. THE PROJECTS WILL BE SUPPORTED BY A WELL-ORGANIZED ADMINISTRATIVE CORE AND TWO STATE-OF-THE-ART SCIENTIFIC CORES IN GENOMICS, AND IMAGING/CELL SORTING. THE CENTER ALSO HAS A SUBSTANTIAL INFRASTRUCTURE BASE AND SIGNIFICANT INSTITUTIONAL SUPPORT. FOR EXAMPLE, CU WILL RECRUIT TWO ADDITIONAL FACULTY MEMBERS AND TWO POST-DOCTORAL FELLOWS TO EXPAND ACTIVITIES OF THIS CENTER OVER THE COURSE OF THE PROJECT PERIOD. PLEDGES OF GRADUATE ASSISTANTSHIPS, EQUIPMENT, AND SPACE FURTHER EXEMPLIFY THE INSTITUTIONAL COMMITMENT. THE CONTINUATION OF THIS COBRE-FUNDED CENTER WILL SIGNIFICANTLY EXPAND RESEARCH IN SOUTH CAROLINA AND WILL FACILITATE RECRUITMENT, TRAINING, AND RETENTION OF A CRITICAL MASS OF INVESTIGATORS WITH CROSS-DISCIPLINARY SKILLS IN THIS IMPORTANT RESEARCH AREA.

ARTIFICIALLY INTELLIGENT MANUFACTURING PARADIGM FOR COMPOSITES (AIM FOR COMPOSITES)

ADVANCED GAS TURBINE SYSTEMS RESEARCH - HIGH EFFICIENCY ENGINES AND TURBINES (AGTSR-HEET)

2016 WRRI 104B PROGRAM

CONSTRUCTION OF THE GRAD

SUPPORT RESEARCH FOR THE LABORATORY FOR ADVANCED PHOTOTONIC COMPOSITIES

HIGH PHOTON DENSITY SPATIOTEMPORAL (OAM+SAM) VECTOR BEAMS FOR MARITIME ENVIRONMENTS

HEALTH CENTER CLUSTER

RADIONUCLIDE WASTE DISPOSAL: DEVELOPMENT OF MULTI-SCALE EXPERIMENTAL AND MODELING CAPABILITIES

UNIVERSITY TRANSPORTATION CENTERS

THE FUNDING WILL BE USED TO REMODEL AND ENLARGE THE CLEMSON VETERINARY DIAGNOSTIC CENTER (CVDC) ENHANCING THE CURRENT PROTECTION OF ANIMAL HEALTH FROM FOREIGN AND EMERGING DISEASES, AND INCREASE FOOD SAFETY FOR CONSUMERS WITHIN THE SOUTHEASTERN UNITED STATES. THIS PROJECT WILL CREATE A CENTER OF VETERINARY EDUCATION FOR STUDENTS COMPLETING THEIR NECROPSY ROTATIONS AND ALSO ALLOW FOR REGULATORY TRAINING FOR GRADUATES INTERESTED IN STATE OR FEDERAL REGULATORY VETERINARY MEDICINE. CLEMSON UNIVERSITY COLLEGE OF VETERINARY MEDICINE IS THE ONLY SCHOOL ASSOCIATED WITH A STATE VETERINARIAN'S OFFICE.

THE PURPOSE OF THIS AGREEMENT IS TO FUND RESEARCH SUPPORTING THE DEFENSE ADVANCED RESEARCH PROJECTS AGENCY (DARPA) BIOLOGICAL TECHNOLOGIES OFFICES (BTO) ARCADIA PROGRAM. THIS EFFORT SHALL BE CARRIED OUT GENERALLY AS SET FORTH IN EXHIBIT B, RESEARCH DESCRIPTION DOCUMENT, DATED NOVEMBER 01, 2022, AND IN THE RECIPIENTS REVISED PROPOSAL TITLED, ECO-COATING ENGINEERING CONTROL OF ORGANIC COATINGS ON AUTONOMOUS NAVY GLIDERS, DATED JULY 21, 2022, COPIES OF WHICH ARE IN THE POSSESSION OF BOTH PARTIES.

AN INTEGRATED MULTI-MATERIAL DIGITAL LIFE CYCLE APPROACH FOR ADDITIVE MANUFACTURING OF GROUND VEHICLE STRUCTURES AND COMPONENTS

1. AWARD PURPOSE: THE PURPOSE OF THIS AGREEMENT IS TO CONDUCT SURVEY, REGULATORY, OUTREACH, AND TREE REMOVAL OPERATIONS IN SUPPORT OF THE ASIAN LONGHORNED BEETLE- ALB (ANOPLOPHORA GLABRIPENNIS) ERADICATION PROGRAM IN CHARLESTON AND DORCHESTER COUNTIES. 2. ACTIVITIES TO BE PERFORMED: COMPREHENSIVE DELIMITATION AND DETECTION SURVEYS THROUGHOUT THE ALB REGULATED AREA, TO BE CONDUCTED PRIMARILY BY CONTRACTED SURVEY PERSONNEL ADMINISTERED BY CLEMON DEPARTMENT OF PLANT INDUSTRY. ESTIMATING APPROXIMATELY 5518 ACRES TO BE SURVEYED DURING THE PERFORMANCE PERIOD. OUTREACH AND EDUCATION EFFORTS, AT LEAST 14 EVENTS DURING THE PERFORMANCE PERIOD, THROUGHOUT THE STATE TO GAIN SUPPORT FROM INDUSTRY GROUPS, THE GENERAL PUBLIC, AND OTHER AFFECTED STAKEHOLDERS. REGULATORY OPERATIONS TO INCLUDE ISSUANCE OF COMPLIANCE AGREEMENTS, COMPLIANCE TRAININGS AND MONITORING, STATE-WIDE SURVEYS, AND ENFORCEMENT OF THE REGULATIONS. ASSIST AND SUPPORT OPERATIONS TO REMOVE INFESTED AND HIGH-RISK HOST TREES, AND DEREGULATE REGULATED MATERIAL. 3. DELIVERABLES AND EXPECTED OUTCOMES: EXPECTED OUTCOMES ARE THE CONTAINMENT AND EVENTUAL ERADICATION OF ASIAN LONGHORNED BEETLE FROM SOUTH CAROLINA. ALL DATA PERTAINING TO ALB SURVEY AND TREE REMOVAL ACTIVITIES WILL BE COLLECTED IN APHIS-APPROVED GEOSPATIAL MOBILE DATA COLLECTION APPLICATIONS AND HOSTED IN THE APHIS GIS PORTAL. 4. INTENDED BENEFICIARY(IES): SOUTH CAROLINA FORESTRY AND GREEN INDUSTRY STAKEHOLDERS, AND THE GENERAL PUBLIC. 5. SUBRECIPIENT ACTIVITIES, IF KNOWN OR SPECIFIED AT THE TIME OF AWARD: NONE.

ART: STRIDE - STIMULATING TRANSLATION OF RESEARCH VIA INTENTIONAL DEVELOPMENT AND ECOSYSTEM -DISCOVERIES AND INNOVATIONS FROM UNIVERSITIES? FOUNDATIONAL RESEARCH IN SCIENCE AND ENGINEERING HAVE BEEN THE CORNERSTONE FOR ADVANCEMENTS IN THE NATION?S HEALTH, PROSPERITY, AND WELFARE. TO TRANSLATE SUCH INNOVATIONS INTO ECONOMIC AND SOCIETAL BENEFITS, UNIVERSITY FACULTY, SCHOLAR, AND STUDENTS WILL NEED SKILLSETS DIFFERENT FROM THEIR ACADEMIC TRAINING AND SUPPORTS OFTEN SCARCE IN MOST UNIVERSITIES. CLEMSON UNIVERSITY HAS SEEN STRONG, STEADY GROWTH IN SPONSORED RESEARCH IN THE PAST DECADE; ITS PACE OF RESEARCH TRANSLATION, HOWEVER, HAS REMAINED AT A LOWER LEVEL. THIS PROJECT, TITLED STIMULATING TRANSLATION OF RESEARCH VIA INTENTIONAL DEVELOPMENT AND ECOSYSTEM (STRIDE), WILL BROADLY ENGAGE CLEMSON UNIVERSITY STAKEHOLDERS TO IDENTIFY THE LIMITING FACTORS AND A PATH TOWARD SIGNIFICANT TRANSFORMATION IN THE UNIVERSITY?S RESEARCH TRANSLATION CAPACITY, IN LINE WITH THE UNIVERSITY?S LAND GRANT COMMITMENT. STRIDE?S GOALS INCLUDE: BOOTSTRAPPING A ROADMAP TO GROW THE UNIVERSITY?S RESEARCH TRANSLATION SUPPORT INFRASTRUCTURE IN THE TECHNOLOGY TRANSFER OFFICE, COLLEGES, AND INNOVATION CENTER; EMPOWER FACULTY AND STUDENTS TO PURSUE RESEARCH TRANSLATION AND CREATE RESEARCH TRANSLATION SUPPORT ENTITIES ACROSS THE INSTITUTION; PROVIDE FINANCIAL AND OTHER SUPPORT TO SEED TRANSLATIONAL RESEARCH PROJECTS WITH HIGH POTENTIAL FOR IMPACTFUL TRANSLATION. STRIDE WILL DEVELOP TRAINING PROGRAMS AND ENGAGEMENT ACTIVITIES ACROSS ALL COLLEGES TO SUPPORT ITS EDUCATION, RESEARCH, ECONOMIC, AND SOCIETAL MISSIONS. STRIDE WILL ALSO BRING THE REGION?S INNOVATION ECOSYSTEM CLOSER THAN EVER THROUGH JOINT PROGRAM DEVELOPMENTS AND STREAMLINED SUPPORT THROUGH STAGES OF INNOVATION. DIVERSITY, EQUITY, INCLUSION, AND ACCESSIBILITY CONSIDERATIONS WILL GUIDE STRIDE FROM INTAKE OF PARTICIPANTS AND INNOVATION PROJECTS TO TRANSLATION OUTCOMES. STRIDE WILL BE CLOSELY ALIGNED WITH THE CLEMSON ELEVATE UNIVERSITY STRATEGIC INITIATIVES TO MULTIPLY ITS IMPACTS. STRIDE WILL SIGNIFICANTLY ENHANCE THE SCALE AND PACE OF TRANSLATION OF IDEAS AND KNOWLEDGE INTO TANGIBLE PRODUCTS, SERVICES, TOOLS, AND METHODS THAT WILL ULTIMATELY CREATE LASTING ECONOMIC AND/OR SOCIETAL IMPACTS THROUGH CREATION OF THE NEXT GENERATION WORKFORCE AND UNIVERSITY SUPPORT FRAMEWORK FOR RESEARCH TRANSLATION. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE PLANNED FOR THIS AWARD.

THE PRIMARY INDUSTRY IN SC IS AGRICULTURE, WITH 25,000 FARMS ACROSS 4.7 MILLION ACRES THAT CONTRIBUTES OVER $46 BILLION TO THE STATE'S ANNUAL ECONOMY AND PROVIDES OVER 247,000 JOBS. FORESTRY IS ALSO AN IMPORTANT ECONOMIC DRIVER IN SC, CONTRIBUTING OVER $21.2 BILLION ANNUALLY. WITH SUCH DIVERSE NATURAL RESOURCES ACROSS THE STATE, TOURISM IS ALSO A MAJOR ECONOMIC FORCE, ACCOUNTING FOR EXPENDITURES OF $24.4 BILLION IN 2019. THE 5.1 MILLION PEOPLE LIVING IN SC ARE CRUCIAL TO MAINTAINING THE QUALITY OF LIFE AND CONSERVATION OF THE NATURAL BEAUTY IN SC, PARTICULARLY YOUTH, SINCE THEY ARE OUR FUTURE STEWARDS OF THE STATE. THE LIVELIHOOD AND QUALITY OF LIFE FOR SC RESIDENTS IS WHAT DRIVES THE PROGRAMMING AND RESEARCH FOCUSES FOR CLEMSON UNIVERSITY AND SOUTH CAROLINA STATE UNIVERSITY (SC STATE). THE PLAN OF WORK REFLECTS RESEARCH AND EXTENSION ACTIVITIES TO BENEFIT AGRIBUSINESS, COMMUNITIES, AND CITIZENS OF SC. FOCUS AREAS INCLUDE ADVANCING THE COMPETITIVENESS OF THE AGRICULTURE AND FORESTRY,ECONOMIC DEVELOPMENT, SAFEGUARDING THE FOOD SUPPLY, PRESERVING NATURAL RESOURCES, AND PREPARING THE YOUNGER GENERATIONS TO BECOME PRODUCTIVE CITIZENS. AGRISYSTEMS PRODUCTIVITY AND PROFITABILITY CLEMSON EXTENSION 1. INCREASE THE ADOPTION OF PRACTICES THAT REDUCE NUISANCE AND ENVIRONMENTAL IMPACTS THROUGH EDUCATION IN THE AREAS OF CONTROL OF ODORS AND VECTORS, PROTECTION OF WATER QUALITY, NUTRIENT MANAGEMENT, CITING OF FACILITIES, AND ALTERNATIVE WASTE HANDLING PRACTICES WITH AN EMPHASIS ON CONFINED ANIMAL PRODUCTION FACILITIES. 2. EMERGING TOOLS AND PRACTICES TO INCREASE CROP PRODUCTION, DECREASE OPERATING COSTS, AND REDUCE ENVIRONMENTAL IMPACTS FOR SPECIFIC FARM CONDITIONS TO ENSURE FARM PROFITABILITY AND ENVIRONMENTAL SUSTAINABILITY. AGRIBUSINESS AND COMMUNITY DEVELOPMENT CLEMSON AND SC STATE EXTENSION 1. PROVIDE EDUCATIONAL PROGRAMS DIRECTED AT TEACHING MANAGEMENT SKILLS THAT ENSURE LONG-TERM PROFITABILITY AND SUSTAINABILITY FOR THE FARM BUSINESS SUCH AS BUSINESS PLANNING, CREATIVE PROBLEM SOLVING, ASSESSING ALTERNATE ENTERPRISE COMBINATIONS AND TECHNOLOGIES FOR PROFITABILITY WHILE MANAGING MARKET AND FINANCIAL RISKS AND MAINTAINING THE INTEGRITY OF THE ENVIRONMENT. 2. PROGRAMS WILL FOCUS ON PROVIDING EDUCATIONAL OPPORTUNITIES THAT ADDRESS CURRENT ISSUES AND INDUSTRY TRENDS IN AGRICULTURE IN THE HIGH SCHOOLS AND MIDDLE SCHOOLS ACROSS THE STATE TO PREPARE A FUTURE LABOR FORCE IN AGRICULTURE. 3. PROGRAMS WILL CONTINUE TO BE OFFERED TO COMMUNITIES TO ASSIST FARMERS AND OTHER AGRICULTURALISTS TO REMAIN ON THE CUTTING EDGE OF TECHNOLOGY AND BUSINESS SKILLS. ENVIRONMENTAL AND NATURAL RESOURCES CONSERVATION CLEMSON EXTENSION 1. EDUCATIONAL PROGRAMMING TO ADDRESS THE IMPACTS OF LAND USE, AND TO PROMOTE BEST MANAGEMENT PRACTICES (BMP'S) AT ALL LEVELS OF LAND OWNERSHIP (PRIVATE AND PUBLIC). 2. EQUINE TRAFFIC IN SC, WHICH IS ESTIMATED AT 750,000 HORSES ACROSS THE STATE, POSES A FUNDAMENTAL MANAGEMENT PROBLEM OF EROSION CONTROL THE PREVENTION OF STREAM SEDIMENTATION AND FECALCONTAMINATION OF SURFACE WATERS. INCREASED KNOWLEDGE ABOUT WETLAND ECOSYSTEMS, MANKIND'S IMPACT ON WATER QUALITY AND WHAT CAN BE DONE TO ENSURE PROPER WATER QUALITY. 3. WILDLIFE AND WILDLIFE-RELATED ACTIVITIES CONTRIBUTE MORE THAN $1.5 BILLION DOLLARS ANNUALLY TO THE STATE'S ECONOMY. THERE ARE 12.9 MILLION ACRES OF FORESTS IN SC AND FORESTRY AN ECONOMIC IMPACT OF $21 BILLION ANNUALLY. WE WILL PROVIDE PROGRAMMING IN THESE AREAS TO SUSTAIN FORESTS AND WATERWAYS. 4. WATER IMPOUNDMENTS, PONDS AND MANAGED WETLANDS ALSO IMPACT THE QUALITY OF LIFE IN SC AND PROVIDE HABITAT FOR WILDLIFE AND RECREATIONAL OPPORTUNITIES FOR RESIDENTS. PROGRAMS AIMED AT PROVIDING LANDOWNERS AND NATURAL RESOURCE MANAGERS WITH THE TOOLS, INFORMATION, AND ECONOMIC INCENTIVES TO MAINTAIN AND ENHANCE LANDS FOR WILDLIFE AND FORESTRY ARE PARAMOUNT. 5. THE ENVIRONMENTAL HORTICULTURE (OR "GREEN") INDUSTRY COMPLEX INCLUDES PRODUCTION FIRMS (NURSERY, GREENHOUSE, AND SOD PRODUCERS), HORTICULTURAL SERVICE FIRMS (LANDSCAPE, LAWN, AND TREE CARE PROFESSIONALS), URBAN FORESTERS AND ARBORISTS, PRIVATE AND PUBLIC GROUN DS WORKERS, LANDSCAPE PEST MANAGEMENT PROFESSIONALS, AND RETAIL GARDEN CENTERS. WE WILL ADDRESS THE ECONOMIC, ENVIRONMENTAL, AND SOCIAL ASPECTS OF ENVIRONMENTAL HORTICULTURE TO HELP CLIENTELE INCREASE THEIR KNOWLEDGE AND ADOPTION OF PRACTICES IN VARIOUS AREAS OF. FOOD SAFETY, SECURITY, AND NUTRITION CLEMSON EXTENSION 1. CONTINUE TO OFFER FSMA CERTIFICATIONS ON THE FOLLOWING: FSMA PREVENTIVE CONTROLS FOR HUMAN FOOD; FSMA PREVENTIVE CONTROLS FOR ANIMAL FOOD; FSMA PRODUCE SAFETY RULE AND FSMA FOREIGN SUPPLIER VERIFICATION PROGRAMS. 2. RETAIL FOOD SAFETY IS CRITICAL FOR THE STATE OF SC. TRAVEL AND TOURISM AND THE RELATED RETAIL FOOD SERVICE INDUSTRY ARE SC'S LARGEST ECONOMIC DRIVERS. TRAINING RETAIL MANAGERS AND EMPLOYEES IN SAFE FOOD HANDLING PRACTICES ARE KEY TO MAINTAINING A HEALTHY TOURISM EXPERIENCE AND TO REPEAT VISITORS. CLEMSON AND SC STATE EXTENSION 1. WE ARE WELL-POSITIONED TO FOSTER A CULTURE OF HEALTH LEVERAGING PARTNERSHIPS WITH PUBLIC HEALTH SCIENCES RESEARCHERS AND HEALTH DELIVERY SYSTEMS TO IMPROVE HEALTH, WELLNESS, AND NUTRITION. 2. SC STATE WILL CONDUCT FSMA OUTREACH AND EDUCATION TRAINING TO UNDERSERVED SOCIALLY DISADVANTAGED VEGETABLE PRODUCERS ACROSS THE SIX REGIONS. YOUTH AND FAMILY DEVELOPMENT CLEMSON AND SC STATE EXTENSION 1. THE SC 4-H YOUTH DEVELOPMENT PROGRAM WILL WORK TO EMPOWER YOUTH TO BECOME HEALTHY, PRODUCTIVE, AND CONTRIBUTING MEMBERS OF SOCIETY. 2. AG INNOVATION SCHOLARS PROGRAM WILL ADDRESS A CRITICAL WORKFORCE NEED BY EXPANDING EDUCATIONAL OPPORTUNITIES TO STUDENTS INTERESTED IN PURSUING AND COMPLETING A BACCALAUREATE DEGREE IN FOOD, AGRICULTURE, NATURAL RESOURCES, AND HUMAN SCIENCES. 3. THE HELPING YOUTH PURSUE EXCELLENCE (HYPE) PROGRAM WILL INCREASE THE POSTSECONDARY COMPLETION RATE OF STUD ENTS IN UNDERSERVED COMMUNITIES. MULTISTATE EXTENSION ACTIVITIES CLEMSON UNIVERSITY MULTI-STATE PROGRAMS 1. SOUTHERN REGION FRUIT CONSORTIUM: COLLABORATIONBETWEEN NORTH CAROLINA STATE UNIVERSITY, CLEMSON UNIVERSITY AND INSTITUTIONS IN GEORGIA, VIRGINIA, TENNESSEE, AND ARKANSAS. 2. TOBACCO, APPLE AND STRAWBERRY RESEARCH WITH THE UNIVERSITY OF GEORGIA AND NC STATE. 3. THE REGIONAL PEACH INITIATIVE: PARTNERSHIP BETWEEN SC AND GEORGIA. 4. THE ORCHARD FLOOR MANAGEMENT: DETERMINE THE IMPACT GROUND COVER MANIPULATION HAS ON WINE GRAPE VIGOR. 5. REGIONAL APPLE INITIATIVE: PARTNERSHIP BETWEEN SC, GEORGIA, AND NORTH CAROLINA.

THE PRIMARY INDUSTRY IN SC IS AGRICULTURE, WITH 25,000 FARMS ACROSS 4.7 MILLION ACRES THAT CONTRIBUTES OVER $46 BILLION TO THE STATE'S ANNUAL ECONOMY AND PROVIDES OVER 247,000 JOBS. FORESTRY IS ALSO AN IMPORTANT ECONOMIC DRIVER IN SC, CONTRIBUTING OVER $21.2 BILLION ANNUALLY. WITH SUCH DIVERSE NATURAL RESOURCES ACROSS THE STATE, TOURISM IS ALSO A MAJOR ECONOMIC FORCE, ACCOUNTING FOR EXPENDITURES OF $24.4 BILLION IN 2019. THE 5.1 MILLION PEOPLE LIVING IN SC ARE CRUCIAL TO MAINTAINING THE QUALITY OF LIFE AND CONSERVATION OF THE NATURAL BEAUTY IN SC, PARTICULARLY YOUTH, SINCE THEY ARE OUR FUTURE STEWARDS OF THE STATE. THE LIVELIHOOD AND QUALITY OF LIFE FOR SC RESIDENTS IS WHAT DRIVES THE PROGRAMMING AND RESEARCH FOCUSES FOR CLEMSON UNIVERSITY AND SOUTH CAROLINA STATE UNIVERSITY (SC STATE). THE PLAN OF WORK REFLECTS RESEARCH AND EXTENSION ACTIVITIES TO BENEFIT AGRIBUSINESS, COMMUNITIES, AND CITIZENS OF SC. FOCUS AREAS INCLUDE ADVANCING THE COMPETITIVENESS OF THE AGRICULTURE AND FORESTRY, ECONOMIC DEVELOPMENT, SAFEGUARDING THE FOOD SUPPLY, PRESERVING NATURAL RESOURCES, AND PREPARING THE YOUNGER GENERATIONS TO BECOME PRODUCTIVE CITIZENS. THE MAJOR PROGRAM AREAS FOR CLEMSON EXTENSION INCLUDE: AGRISYSTEMS PRODUCTIVITY AND PROFITABILITY, AGRIBUSINESS AND COMMUNITY DEVELOPMENT, ENVIRONMENTAL AND NATURAL RESO URCES CONSERVATION, FOOD SAFETY, SECURITY AND NUTRITION, AND YOUTH AND FAMILY DEVELOPMENT. CLEMSON EXTENSION ALSO PARTICIPATES IN MULTIPLE MULTISTATE EXTENSION ACTIVITIES, INCLUDING THE SOUTHERN REGION FRUIT CONSORTIUM, TOBACCO, APPLE AND STRAWBERRY RESEARCH WITH UGA AND NC STATE, THE REGIONAL PEACH INITIATIVE WITH UGA, THE ORCHARD FLOOR MANAGEMENT PROJECT, AND THE REGIONAL APPLE INITIATIVE.

THE PRIMARY INDUSTRY IN SC IS AGRICULTURE, WITH 25,000 FARMS ACROSS 4.7 MILLION ACRES THAT CONTRIBUTES OVER $46 BILLION TO THE STATE'S ANNUAL ECONOMY AND PROVIDES OVER 247,000 JOBS. FORESTRY IS ALSO AN IMPORTANT ECONOMIC DRIVER IN SC, CONTRIBUTING OVER $21.2 BILLION ANNUALLY. WITH SUCH DIVERSE NATURAL RESOURCES ACROSS THE STATE, TOURISM IS ALSO A MAJOR ECONOMIC FORCE, ACCOUNTING FOR EXPENDITURES OF $24.4 BILLION IN 2019. THE 5.1 MILLION PEOPLE LIVING IN SC ARE CRUCIAL TO MAINTAINING THE QUALITY OF LIFE AND CONSERVATION OF THE NATURAL BEAUTY IN SC, PARTICULARLY YOUTH, SINCE THEY ARE OUR FUTURE STEWARDS OF THE STATE. THE LIVELIHOOD AND QUALITY OF LIFE FOR SC RESIDENTS IS WHAT DRIVES THE PROGRAMMING AND RESEARCH FOCUSES FOR CLEMSON UNIVERSITY AND SOUTH CAROLINA STATE UNIVERSITY (SC STATE). THE PLAN OF WORK REFLECTS RESEARCH AND EXTENSION ACTIVITIES TO BENEFIT AGRIBUSINESS, COMMUNITIES, AND CITIZENS OF SC. FOCUS AREAS INCLUDE ADVANCING THE COMPETITIVENESS OF THE AGRICULTURE AND FORESTRY, ECONOMIC DEVELOPMENT, SAFEGUARDING THE FOOD SUPPLY, PRESERVING NATURAL RESOURCES, AND PREPARING THE YOUNGER GENERATIONS TO BECOME PRODUCTIVE CITIZENS. THE MAJOR PROGRAM AREAS FOR CLEMSON EXTENSION INCLUDE: AGRISYSTEMS PRODUCTIVITY AND PROFITABILITY, AGRIBUSINESS AND COMMUNITY DEVELOPMENT, ENVIRONMENTAL AND NATURAL RESO URCES CONSERVATION, FOOD SAFETY, SECURITY AND NUTRITION, AND YOUTH AND FAMILY DEVELOPMENT. CLEMSON EXTENSION ALSO PARTICIPATES IN MULTIPLE MULTISTATE EXTENSION ACTIVITIES, INCLUDING THE SOUTHERN REGION FRUIT CONSORTIUM, TOBACCO, APPLE AND STRAWBERRY RESEARCH WITH UGA AND NC STATE, THE REGIONAL PEACH INITIATIVE WITH UGA, THE ORCHARD FLOOR MANAGEMENT PROJECT, AND THE REGIONAL APPLE INITIATIVE.

THE PRIMARY INDUSTRY IN SC IS AGRICULTURE, WITH 25,000 FARMS ACROSS 4.7 MILLION ACRES THAT CONTRIBUTES OVER $46 BILLION TO THE STATE'S ANNUAL ECONOMY AND PROVIDES OVER 247,000 JOBS. FORESTRY IS ALSO AN IMPORTANT ECONOMIC DRIVER IN SC, CONTRIBUTING OVER $21.2 BILLION ANNUALLY. WITH SUCH DIVERSE NATURAL RESOURCES ACROSS THE STATE, TOURISM IS ALSO A MAJOR ECONOMIC FORCE, ACCOUNTING FOR EXPENDITURES OF $24.4 BILLION IN 2019. THE 5.1 MILLION PEOPLE LIVING IN SC ARE CRUCIAL TO MAINTAINING THE QUALITY OF LIFE AND CONSERVATION OF THE NATURAL BEAUTY IN SC, PARTICULARLY YOUTH, SINCE THEY ARE OUR FUTURE STEWARDS OF THE STATE. THE LIVELIHOOD AND QUALITY OF LIFE FOR SC RESIDENTS IS WHAT DRIVES THE PROGRAMMING AND RESEARCH FOCUSES FOR CLEMSON UNIVERSITY AND SOUTH CAROLINA STATE UNIVERSITY (SC STATE). THE PLAN OF WORK REFLECTS RESEARCH AND EXTENSION ACTIVITIES TO BENEFIT AGRIBUSINESS, COMMUNITIES, AND CITIZENS OF SC. FOCUS AREAS INCLUDE ADVANCING THE COMPETITIVENESS OF THE AGRICULTURE AND FORESTRY, ECONOMIC DEVELOPMENT, SAFEGUARDING THE FOOD SUPPLY, PRESERVING NATURAL RESOURCES, AND PREPARING THE YOUNGER GENERATIONS TO BECOME PRODUCTIVE CITIZENS. THE MAJOR PROGRAM AREAS FOR CLEMSON EXTENSION INCLUDE: AGRISYSTEMS PRODUCTIVITY AND PROFITABILITY, AGRIBUSINESS AND COMMUNITY DEVELOPMENT, ENVIRONMENTAL AND NATURAL RESO URCES CONSERVATION, FOOD SAFETY, SECURITY AND NUTRITION, AND YOUTH AND FAMILY DEVELOPMENT. CLEMSON EXTENSION ALSO PARTICIPATES IN MULTIPLE MULTISTATE EXTENSION ACTIVITIES, INCLUDING THE SOUTHERN REGION FRUIT CONSORTIUM, TOBACCO, APPLE AND STRAWBERRY RESEARCH WITH UGA AND NC STATE, THE REGIONAL PEACH INITIATIVE WITH UGA, THE ORCHARD FLOOR MANAGEMENT PROJECT, AND THE REGIONAL APPLE INITIATIVE.

BREEDING HIGH YIELDING BIOENERGY SORGHUM FOR THE NEW BIOENERGY BELT

CLEMSON UNIVERSITY - FY22 SMITH-LEVER

COOPERATIVE EXTENSION PROGRAM AT 1862 LAND-GRANT INSTITUTIONS - CLEMSON UNIVERSITY

CLEMSON UNIVERSITY - FY20 SMITH LEVER

CLEMSON UNIVERSITY - FY21 SMITH-LEVER

RII TRACK-2 FEC: ADVANCED BIOMANUFACTURING: CATALYZING IMPROVED HOST DEVELOPMENT AND HIGH QUALITY MEDICINES THROUGH GENOME TO PHENOME PREDICTIONS

COMMUNITY PROJECT FUNDING/CONGRESSIONALLY DIRECTED SPENDING - CONSTRUCTION

COMMUNITY PROJECT FUNDING/CONGRESSIONALLY DIRECTED SPENDING - CONSTRUCTION

RII TRACK-2 FEC: THE CREATION OF NEXT-GENERATION TOOLS FOR NEUROSCIENCE - NONINVASIVE RADIOLUMINESCENCE APPROACHES TO OPTOGENETICS

PARTNERS PROJECT (PROVIDING APPRENTICESHIPS THROUGH RESIDENCY TEAMS FOR NOVICE EDUCATOR RETENTION AND STUDENT ACHIEVEMENT)

BIOENGINEERING CENTER FOR REGENERATION AND FORMATION OF TISSUES (SC BIOCRAFT)

ADVANCED CYBERINFRASTRUCTRE - RESEARCH AND EDUCATIONAL FACILITATION: CAMPUS-BASED COMPUTATIONAL RESEARCH SUPPORT

COOPERATIVE EXTENSION PROGRAM AT 1862 LAND-GRANT INSTITUTION - CLEMSON UNIVERSITY

COOPERATIVE EXTENSION PROGRAM AT 1862 LAND-GRANT INSTITUTIONS - CLEMSON UNIVERSITY

COMMUNITY COLLABORATION FOR COUNSELORS (CCC): INCREASING SCHOOL-BASED MENTAL HEALTH SUPPORT

COOPERATIVE EXTENSION PROGRAMS AT 1862 LAND-GRANT INSTITUTION - CLEMSON UNIVERSITY

DE-EE0009656 TITLED MANUFACTURING DEMONSTRATION OF A LARGE-SCALE, MULTI-MATERIAL PASSENGER VEHICLE SUB-SYSTEM. NEW AWARD TO CLEMSON UNIVERSITY.

COOPERATIVE EXTENSION PROGRAMS AT 1862 LAND-GRANT INSTITUTIONS - CLEMSON UNIVERSITY

CLEMSON UNIVERSITY- NEW NON-COMPETITIVE AWARD CLEMSON UNIVERSITY WILL PERFORM PLANT PHENOTYPING AND DATA ANALYSIS, EXPAND GENOTYPING EFFORTS TO PREDICT HETEROSIS, AND COORDINATE SEED PRODUCTION.

1. AWARD PURPOSE:TO FACILITATE THE DETECTION, REGULATION OF HOST MATERIAL AND ERADICATIONOF ASIAN LONGHORNED BEETLE IN SOUTH CAROLINA.2. ACTIVITIES TO BE PERFORMED:DELIMITATION OF ALB INFESTATION.ASSIST IN REMOVALS OF INFESTED AND HIGH-RISK HOSTS, DEREGULATION OFINFESTED MATERIALS.OUTREACH AND EDUCATION TO COMMUNITIES, INDUSTRY, AND MUNICIPALITIESSURVEY OF HIGH-RISK HOST SITES STATEWIDETRAINING OF STAFF AND IMPLEMENTATION OF QUALITY ASSURANCE PROTOCOLS.3. DELIVERABLES AND EXPECTED OUTCOMES:IDENTIFY PRESENT RANGE OF ALB IN SOUTH CAROLINA, IDENTIFY AVENUES OFINTRODUCTION AND SPREAD, PREVENT FUTURE INTRODUCTIONS, AND SPREAD ANDULTIMATELY ERADICATE ALB FROM SC.4. INTENDED BENEFICIARY(IES): INDUSTRY, PUBLIC, MUNICIPALITIES5. SUBRECIPIENT ACTIVITIES, IF KNOWN OR SPECIFIED AT THE TIME OF AWARD:CONTRACT SURVEYORS, MARSHALLING YARD- RECIPIENT TO BE DETERMINED.

COOPERATIVE EXTENSION PROGRAMS AT 1862 LAND-GRANT INSTITUTION - CLEMSON UNIVERSITY

IMPROVE EXISTING AIRPORT

CENTER OF BIOMATERIALS FOR TISSUE REGENERATION (CBTR)

IMPROVE EXISTING AIRPORT

FULLY INTEGRATED HIGH SPEED MEGAWATT CLASS MOTOR AND HIGH FREQUENCY VARIABLE SPEED DRIVE SYSTEM

PURPOSE: ECONOMIC DEVELOPMENT INITIATIVE, COMMUNITY PROJECT FUNDING/CONGRESSIONAL DIRECTED SPENDING AWARDS ARE AUTHORIZED UNDER THE CONSOLIDATED APPROPRIATIONS ACT, 2022 PUBLIC LAW 117-328 AND THE EXPLANATORY STATEMENT FOR DIVISION L OF THAT ACT. PROJECTS SELECTED FOR COMMUNITY PROJECT FUNDING/CONGRESSIONAL DIRECTED SPENDING ARE LISTED IN THE JOINT EXPLANATORY STATEMENT (JES) THAT ACCOMPANIES A SPECIFIC FISCAL YEAR’S APPROPRIATIONS ACT OR CONGRESSIONAL RECORD. THE JES LISTS PROJECT, RECIPIENT, STATE, AMOUNT AND CONGRESSIONAL SPONSOR.; ACTIVITIES TO BE PERFORMED: ECONOMIC DEVELOPMENT INITIATIVE, COMMUNITY PROJECT FUNDING/CONGRESSIONALLY DIRECTED SPENDING AWARD PROJECTS INCLUDE A WIDE VARIETY OF ACTIVITIES THAT RESULT IN ECONOMIC DEVELOPMENT OR COMMUNITY DEVELOPMENT OUTCOMES. HUD WILL NOT KNOW THE FULL SCOPE OF THE PROJECT UNTIL THE RECIPIENT SUBMITS THE REQUIRED PROJECT NARRATIVE AND CONFIRMS ALIGNMENT WITH THE LANGUAGE AS PROVIDED IN THE CONGRESSIONAL RECORD. TO FIND THE DETAILS OF THE GRANT AWARD AS WRITTEN WITHIN THE CONGRESSIONAL RECORD USE THE FOLLOWING LINK AND PATH SELECTIONS TO GET TO THE DESCRIPTION OF THE ECONOMIC DEVELOPMENT INITIATIVE, COMMUNITY PROJECT FUNDING GRANTS HTTPS://WWW.HUD.GOV/PROGRAM_OFFICES/COMM_PLANNING/EDI-GRANTS, SELECT THE FISCAL YEAR OF INTEREST, SCROLL DOWN TO PROGRAM LAWS AND REGULATIONS, UNDER FISCAL YEAR 20XX CONSOLIDATED APPROPRIATIONS ACT, 20XX: CONGRESSIONAL RECORD (JOINT EXPLANATORY STATEMENT).; EXPECTED OUTCOMES: COMPLETION OF THE PROJECT AS DESCRIBED IN THE JOINT EXPLANATORY STATEMENT (JES) PROJECT DESCRIPTION AND SUBSEQUENT APPROVED PROJECT NARRATIVE.; INTENDED BENEFICIARIES: THE PROJECT BENEFICIARIES ARE THE INDIVIDUALS AND/OR ORGANIZATIONS THAT ARE AWARDED GRANT FUNDS OR SERVED BY THE ENTITIES THAT ARE AWARDED GRANT FUNDS AS IDENTIFIED IN THE JES RECIPIENT OR PROJECT DESCRIPTION SECTIONS.; SUBRECIPIENT ACTIVITIES: THE SUBRECIPIENT ACTIVITIES ARE UNKNOWN AT THE TIME OF AWARD.

EXPLORING STRATEGIES TO STRENGTHEN STUDENT TRANSFER TO ENGINEERING -THIS PROJECT WILL CONTRIBUTE TO THE NATIONAL NEED FOR WELL-EDUCATED SCIENTISTS, MATHEMATICIANS, ENGINEERS, AND TECHNICIANS BY SUPPORTING THE RETENTION AND GRADUATION OF HIGH-ACHIEVING, LOW-INCOME STUDENTS WITH DEMONSTRATED FINANCIAL NEED AT CLEMSON UNIVERSITY AND TRI-COUNTY TECHNICAL COLLEGE. A TOTAL OF 48 SCHOLARS PURSUING BACHELOR'S DEGREES IN ENGINEERING WILL RECEIVE ANNUAL SCHOLARSHIPS UP TO $15,000 FOR UP TO FIVE YEARS. SCHOLARS WILL RECEIVE FACULTY MENTORING AND THE PROJECT WILL BUILD STRONG SCHOLAR COHORTS THROUGH PROFESSIONAL DEVELOPMENT ACTIVITIES. ADDITIONAL SUPPORT FOR SCHOLARS WILL INCLUDE RESIDENCY ON THE CLEMSON CAMPUS FOR TRI-COUNTY TECHNICAL COLLEGE SCHOLARS AND POTENTIAL ENGAGEMENT WITH RESEARCH COURSES. THE OVERALL GOAL OF THIS TRACK 3 SCHOLARSHIPS IN STEM PROJECT IS TO INCREASE STEM DEGREE COMPLETION OF ACADEMICALLY TALENTED, LOW-INCOME UNDERGRADUATES WITH DEMONSTRATED FINANCIAL NEED. THERE IS A SIGNIFICANT NATIONAL NEED TO GROW THE STEM WORKFORCE AND NURTURE KEY TALENT THAT WILL ENSURE ECONOMIC COMPETITIVENESS AND PROVIDE DOMESTIC LEADERSHIP ACROSS CRITICAL SECTORS. THIS PROJECT DIRECTLY SPEAKS TO THIS NEED BY SUPPORTING STEM STUDENT SUCCESS, WHICH WILL STRENGTHEN THE WORKFORCE IN ENGINEERING AND OTHER KEY AREAS OF NEED. THE PROJECT WILL BE ASSESSED BY AN EXPERIENCED EVALUATOR, AND THE RESEARCH DATA COLLECTION WILL BE INFORMED BY A TRANSFER STUDENT CAPITAL FRAMEWORK. THE PLANNED RESEARCH WILL CONTRIBUTE TO THE KNOWLEDGE BASE REGARDING EFFECTIVE STRATEGIES TO SUPPORT TALENTED, LOW-INCOME STUDENTS IN STEM. THIS PROJECT IS FUNDED BY NSF'S SCHOLARSHIPS IN SCIENCE, TECHNOLOGY, ENGINEERING, AND MATHEMATICS PROGRAM, WHICH SEEKS TO INCREASE THE NUMBER OF ACADEMICALLY TALENTED, LOW-INCOME STUDENTS WITH DEMONSTRATED FINANCIAL NEED WHO EARN DEGREES IN STEM FIELDS. IT ALSO AIMS TO IMPROVE THE EDUCATION OF FUTURE STEM WORKERS, AND TO GENERATE KNOWLEDGE ABOUT ACADEMIC SUCCESS, RETENTION, TRANSFER, GRADUATION, AND ACADEMIC/CAREER PATHWAYS OF LOW-INCOME STUDENTS. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE PLANNED FOR THIS AWARD.

**AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** STONE FRUIT AND NUT CROPS (PEACH, ALMOND, AND CHERRY) PROVIDE VITAL CONTRIBUTIONS TO HUMAN HEALTH, COMMUNITIES, AND ECONOMIES ACROSS THE U.S. THESE CROPS ARE UNDER SERIOUS THREAT OF RAPID COLLAPSE AND EVENTUAL EXTINCTION DUE TO A DEVASTATING FUNGAL THREAT CALLED ARMILLARIA ROOT ROT (ARR). ARR PRESENTS A MAJOR CHALLENGE TO THE U.S. STONE FRUIT AND NUT INDUSTRY. GROWERS WITH ARR - INFECTED ORCHARDS ARE FACED WITH A PERSISTENT PROBLEM, AS BOTH THE HOST AND THE DISEASE ARE LONG-LIVED. PRODUCERS CANNOT ROTATE TO OTHER SITES DUE TO THE LACK OF UN-INFECTED LAND FOR NEW PLANTINGS, ESPECIALLY CRITICAL IN SC PEACH AND MI CHERRY INDUSTRIES. THEY CANNOT FUMIGATE THE SOIL, AND ONCE AN ENTIRE ORCHARD IS REPLANTED, THEY ARE LEFT WITH THE PROSPECTS OF HAVING TO REPLANT AGAIN NOT LONG AFTER HAVING INVESTED IN THE HIGH ORCHARD ESTABLISHMENT COSTS. WITH THIS SAME SCENARIO IN PEACHES IN THE SOUTHEAST, CHERRIES IN MICHIGAN, AND PEACH, CHERRY, AND ALMOND IN CALIFORNIA, ARR IS A THREAT OF NATIONAL IMPORTANCE. WITHOUT PRACTICES TO ERADICATE THE PATHOGENS OR METHODS TO COUNTERACT REDUCED PRODUCTIVITY, INFECTED SITES ARE UNSUITABLE FOR REPLANTING. THE PATHOGEN IS LONG-LIVED, WITH INOCULUM THAT CAN PERSIST BELOW GROUND FOR MANY YEARS. AS SUCH, LEAVING THE GROUND FALLOW BEFORE REPLANTING WOULD REQUIRE UP TO A DECADE AND HAVE AN UNACCEPTABLE ECONOMIC BURDEN ON PRODUCERS. FURTHERMORE, PLANTING ANOTHER HORTICULTURAL CROP OTHER THAN A PRUNUS SPECIES IS NOT AN ECONOMICALLY VIABLE OPTION, GIVEN THE BROAD HOST RANGE OF ARR (500+ WOODY PLANT SPECIES). WITHOUT SOLUTIONS, THIS LOSS OF PRODUCTION WILL NOT ONLY HAVE DEVASTATING IMPACTS ON THE AFFECTED PRODUCERS AND RURAL COMMUNITIES BUT WILL ALSO CONTRIBUTE TO A REDUCTION IN THE SUPPLY OF THESE PRODUCTS AND POTENTIALLY INCREASED COSTS FOR CONSUMERS.U.S. STAKEHOLDERS AND INDUSTRIES THAT SPAN THESE CROPS HAVE GIVEN ARR THE HIGHEST PRIORITY FOR THE DEVELOPMENT OF SHORT AND LONG-TERM SOLUTIONS TO PRESERVING THESE CRITICAL CROPS AND INDUSTRIES. THE MOST SUSTAINABLE AND EFFECTIVE APPROACH TO MITIGATE THE ARR THREAT TO PEACH, CHERRY, AND ALMOND PRODUCTION IN THE U.S. IS TO DEVELOP GENETICALLY DURABLE ARR-RESISTANT ROOTSTOCKS. WHILE LONG-TERM SOLUTIONS ARE REQUIRED, IN THE INTERIM, SHORT- AND MEDIUM-TERMED SOLUTIONS ARE NECESSARY, WHICH IS WHY THIS PROJECT ENCOMPASSES BOTH. THIS PROJECT WILL IDENTIFY RESISTANT GERMPLASM, CHARACTERIZE THE MODE OF RESISTANCE AND UNDERSTAND THE GENETIC BASE OF THE RESISTANCE BY LINKING THE GENOME WITH PHENOME THROUGH SYSTEMS-SCALE DATASETS, SUCH AS TRANSCRIPTOMICS, METABOLOMICS, ETC., ALONG WITH SOPHISTICATED STATISTICAL METHODS, TO ENABLE GENOMIC SOLUTIONS AND TRANSLATIONAL BREEDING OF NATURAL (LOCAL AND EXOTIC) SOURCES OF ARR RESISTANCE TO DELIVER ARR RESISTANT ROOTSTOCKS IN THE LONGER TERM. THE INDUSTRY WILL PERCEIVE AN IMMEDIATE BENEFIT WITH THE CHANGE IN CULTURAL PRACTICE AND DIRECT UTILIZATION OF NEW SOURCES OF RESISTANCE IN NURSERIES. ABOVE GROUND ROOT COLLAR EXCAVATION CULTURAL PRACTICE (AGRCE), THAT EXTENDS THE LIFESPAN OF ORCHARDS ON ARR INFECTED SITES, AND NURSERY AND PRODUCER EVALUATION OF HORTICULTURAL ACCEPTANCE OF THE RESISTANT MATERIAL, PROVIDE SHORT- AND MEDIUM-TERM SOLUTIONS, RESPECTIVELY, AS THE WORK ON GENETIC RESISTANCE PROGRESSES. CULTURAL PRACTICES HAVE THE POTENTIAL TO REDUCE THE FINANCIAL BURDEN OF ARR TO PRODUCERS BY EXTENDING THE LONG-TERM PRODUCTIVITY OF PRUNUS ORCHARDS, THEREFORE THIS PROJECT WILL IMPLEMENT AGRCE FOR PEACH AND CHERRY AND EXPLORE THE USE OF SECTORAL CHIMERA ROOTSTOCKS IN ALMOND AS A STRATEGY TO INCREASE TREE LONGEVITY UNTIL ARR RESISTANT COMPATIBLE ROOTSTOCKS ARE DEVELOPED. SOCIO-ECONOMIC RESEARCH WILL DETERMINE ECONOMIC EFFECTS OF ARR AND IMPACT OF PROPOSED SOLUTIONS TO PROVIDE GUIDELINES FOR GROWERS, WHILE OUTREACH AND EXTENSION ACTIVITIES WILL TARGET PEACH, CHERRY, AND ALMOND GROWERS AFFECTED BY ARR AND TREE-FRUIT NURSERIES, AS THE KEY PARTNERS IN DELIVERING GENETIC SOLUTIONS TO PRODUCERS, SO THAT NEW KNOWLEDGE CAN BE QUICKLY DISSEMINATED AND FEEDBACK OBTAINED. IN THIS WAY, A RANGE OF CONSUMERS WILL BENEFIT FROM SUSTAINABLE STONE FRUIT AND NUT PRODUCTION, WHICH WOULD INCREASE CONSUMPTION AND IMPROVE HUMAN HEALTH AND PHYSICAL WELL-BEING.

GENETICS OF COCAINE AND METHAMPHETAMINE SENSITIVITY IN DROSOPHILA

THE TECHNICAL GOAL IS TO DEMONSTRATE THE ACCELERATED DISCOVERY, DESIGN, AND LASER CONVERGENT MANUFACTURING OF LOW-TEMPERATURE (< 650°C) OXYGEN-CONDUCTING SOLID OXIDE ELECTROLYZER CELL(LT-O-SOEC) WITH A MINIMUM ACTIVE AREA > 15 CM2, TO ACHIEVE OR EXCEED THE TARGETS OF = 1.2A/CM2 AT 1.3 V/CELL WITH = 3 MV/KHR DEGRADATION RATE. THE GOAL OF THE COMMUNITY BENEFITS PLAN (CBP) IS TO HELP ENSURE THE RESULTS FROM THE PROJECT HAVE A WIDE AND EQUITABLE POSITIVE IMPACT ACROSS UNITED STATE (US) COMMUNITIES WHILE AVOIDING INEQUITABLE NEGATIVE IMPACTS ON ANY SPECIFIC COMMUNITY, PARTICULARLY THOSE HISTORICALLY AT RISK FROM ENERGY-RELATED TECHNOLOGIES OR DEINDUSTRIALIZATION. TO ACHIEVE THE ABOVE-STATED PROJECT GOAL, WE WILL ACHIEVE THE FOLLOWING OBJECTIVES: DURING BUDGET PERIOD 1: OBJECTIVE 1: DESIGN AND VALIDATE THE PERFORMANCE OF NOVEL ELECTROLYTE, ELECTRODE, BUFFER MATERIALS AND INTERFACES. OBJECTIVE 2: HIGH THROUGHPUT FABRICATION, CHARACTERIZATION, AND TESTING OF MICRO-SAMPLE ARRAY TO (1) EFFICIENTLY SCREEN AND DOWN-SELECT VAST COMBINATORY POSSIBILITIES OF INTERFACE, MICROSTRUCTURE, AND CELL ARCHITECTURE FOR OPTIMAL PERFORMANCES; AND (2) QUICKLY ESTABLISH OF DATASETS OF PROCESSING-MATERIAL-PERFORMANCE LINKS FOR MACHINE LEARNING (ML) TRAINING. DIVERSITY, EQUITY, INCLUSION, AND ACCESSIBILITY (DEIA) OBJECTIVE 1: “RECRUITMENT”. SUPPORT RECRUITMENT ACTIVITIES TO ENSURE EQUITABLE OPPORTUNITIES FOR STUDENT RESEARCHERS FROM DIVERSE COMMUNITIES. ENERGY EQUITY OBJECTIVE 2: “HYDROGEN-ORANGE START-UP PRIZE.” INITIATE AND AWARD THE “HYDROGEN-ORANGE PRIZE” EACH YEAR TO THE TEAM OR INDIVIDUALS TO PRESENT THE MOST VIABLE BUSINESS OPPORTUNITY RELATED TO HYDROGEN AND CLEAN ENERGY TECHNOLOGIES. WORKFORCE OBJECTIVE 2: “RESEARCH EXPERIENCE FOR TEACHERS (RET) SUPPLEMENT.” PROVIDE A NEW OPPORTUNITY FOR 1 OR 2 ADDITIONAL TEACHERS PER YEAR TO PARTICIPATE AND WORK ON PROJECTS RELATED TO CLEAN ENERGY AND HYDROGEN RESEARCH. DURING BUDGET PERIOD 2: OBJECTIVE 3: ESTABLISH AND VALIDATE ML MODELS TO PREDICT AND DESIGN THE MATERIALS AND INTERFACE FOR THE HIGH-PERFORMANCE LT-O-SOEC, AND THE APPROPRIATE PROCESSING PARAMETERS FOR THE ULTRA-FAST, LASER-SELECTIVE CONVERGENT MANUFACTURING (ULCM) OF LT-O-SOEC. OBJECTIVE 4: COMPUTATIONAL MODELING TO PREDICT THE DEFECT-FREE LASER PROCESSING PARAMETERS AND DESIGN THE OPTIMAL THERMOMECHANICAL STABILITY AT BOTH MEMBRANE ELECTRODE ASSEMBLY (MEA) AND STACK LEVELS. OBJECTIVE 5: ESTABLISH ML-BASED, IN-PROCESS MONITORING OF MICROSTRUCTURE AND DEFECTS FOR QUALITY ASSURANCE. DEIA OBJECTIVE 2: “MENTOR-LEARNER.” ESTABLISH A DEIA “MENTOR-LEARNER” PROGRAM, MATCHING RESEARCHERS (GRADUATE, SMALL BUSINESS) WITH THE DIVERSITY OF NEXT-GENERATION LEARNERS (SCHOOLS, TEACHERS, ETC.). ENERGY EQUITY OBJECTIVE 1: “SUMMER ENERGY EQUITY WORKSHOP AND PROJECT.” ESTABLISH A WORKSHOP EACH YEAR, FOCUSING ON CHALLENGES AND OPPORTUNITIES TO ADVANCE ENERGY EQUITY THROUGH HYDROGEN AND RELATED CLEAN ENERGY TECHNOLOGIES. DURING BUDGET PERIOD 3: OBJECTIVE 6: ULCM OF LARGE AREA (> 15 CM2) MEA WITH PRECISELY CONTROLLED MICROSTRUCTURE AND CRYSTALLINE PHASE OF DENSE ELECTROLYTE, POROUS ELECTRODES, AND HETEROGENEOUS INTERFACE. OBJECTIVE 7: SOEC STACK PACKAGING AND TESTING TO VALIDATE THE LONG-TERM PERFORMANCE STABILITY OF LT-O-SOEC STACKS.

THE ASSISTING SPECIALTY CROP EXPORTS SUSTAINABLE PACKAGING INNOVATION LAB (ASCE-SPIL) PROJECT SEEKS TO SUPPORT RESEARCH AND IMPLEMENTATION PROJECTS THAT ADVANCE U.S. SPECIALTY CROP EXPORTS BY DEVELOPING INNOVATIVE SOLUTIONS TO EMERGING FOREIGN REGULATORY REQUIREMENTS FOR PACKAGING AND LABELING OF SPECIALTY CROPS. INTENDED BENEFICIARIES ARE U.S. SPECIALTY CROP PRODUCERS AND EXPORTERS, REGULATORY OFFICIALS, FARMERS, PRIVATE SECTOR, ACADEMIA, AND OTHER STAKEHOLDERS AS APPROPRIATE. THE RECIPIENT OF THIS AWARD WILL ACT AS THE MANAGING ENTITY OF ASCE-SPIL. IN THIS CAPACITY, THE RECIPIENT WILL ESTABLISH THE ASCE-SPIL AND DEVELOP, SELECT, AND MANAGE A PORTFOLIO OF SUBAWARDS FOR INDUSTRY AND ACADEMIC RESEARCHERS WORKING ON SUSTAINABLE PACKAGING R <(>&<)>D AND COMMERCIALIZATION PILOT ACTIVITIES TO SUPPORT U.S. EXPORTS OF SPECIALTY CROPS.

COOPERATIVE EXTENSION PROGRAM AT 1862 LAND-GRANT INSTITUTIONS - CLEMSON UNIVERSITY

COOPERATIVE EXTENSION PROGRAM AT 1862 LAND-GRANT INSTITUTIONS - CLEMSON UNIVERSITY

INTEGRATING BIOMECHANICS AND CELL BIOLOGY TO UNDERSTAND TMJ PATHOLOGY

CLEMSON UNIVERSITY’S COLLEGE OF VETERINARY MEDICINE (CVM) WILL BE THE FIRST IN SOUTH CAROLINA. THE CLEMSON CVM WILL LEVERAGE THE UNIVERSITY’S EXISTING ANIMAL HEALTH PROGRAMS AND INFRASTRUCTURE TO CREATE A VETERINARY MEDICAL WORKFORCE TO FILL A STATEWIDE AND NATIONAL SHORTAGE OF VETERINARIANS. THE NEED FOR VETERINARIANS IN UNDERSERVED RURAL AREAS, FOR FARM ANIMALS, AND IN PUBLIC PRACTICE IS RECOGNIZED BY CLEMSON. A MODERN ROBOTICALLY MILKED DAIRY HERD, BEEF COW/CALF HERDS, A SHEEP FLOCK, A HORSE FARM, A POULTRY UNIT, AN AQUACULTURE UNIT, A LAB ANIMAL RESEARCH FACILITY AND A ROBUST AND RESPECTED PRE-VETERINARY PROGRAM ARE ALREADY WELL ESTABLISHED AT CLEMSON UNIVERSITY, A LAND-GRANT CARNEGIE R-1 RESEARCH INSTITUTION. IN ADDITION, CLEMSON IS ALSO HOME TO THE SOUTH CAROLINA STATE VETERINARIAN’S OFFICE (STATE ANIMAL HEALTH AUTHORITY), ANIMAL HEALTH PROGRAMS, THE CLEMSON VETERINARY DIAGNOSTIC CENTER, AND THE SOUTH CAROLINA MEAT-POULTRY INSPECTION DEPARTMENT THAT SUPPORT THE UNIVERSITY’S MISSION OF TEACHING, RESEARCH, AND PUBLIC SERVICE. CLEMSON BEGAN VETERINARY INSPECTION WORK IN 1901, SO CLEMSON HAS BEEN IMMERSED IN VETERINARY MEDICINE FOR OVER A CENTURY EVEN WITHOUT A VETERINARY SCHOOL. WE BELIEVE CLEMSON IS UNIQUELY EQUIPPED, LEVERAGING ITS EXISTING ASSETS AND EXPERIENCE, TO HELP ADDRESS THIS NEED FOR FARM ANIMAL, RURAL, AND PUBLIC PRACTICE VETERINARIANS AS IT DESIGNS NEW FACILITIES, DEVELOPS ADMISSIONS REQUIREMENTS, AND PLANS FOR ITS DISTRIBUTED MODEL CURRICULUM. WE THINK IT IS CRITICAL FOR VETERINARY STUDENTS TO NOT ONLY RECEIVE A COMPREHENSIVE EDUCATION IN FARM ANIMALS BUT ALSO FOR THE EQUIPMENT AND TEACHING AIDES USED IN DELIVERING THIS EDUCATION TO BE STATE-OF-THE-ART TO AVOID THE PERCEPTION THAT PRACTICE ON FARM ANIMALS IN RURAL AREAS IS NOT CONSIDERED A “SECOND CLASS” CAREER CHOICE. THE FUNDS PROVIDED BY THIS GRANT WILL PROVIDE FOR STATE-OF-THE-ART EQUIPMENT AND OTHER MATERIALS AND SUPPLIES FOR FARM ANIMAL INSTRUCTION AND SKILLS DEVELOPMENT AND HELP TEST THAT THEORY.

RESEARCH ALLIANCE FOR ACCESSIBLE VOTING (RAAV): MAKING VOTING ACCESSIBLE FOR EVERYONE

SOUTH CAROLINA COUNTY HEALTH EXTENSION: HIGH OBESITY PREVENTION AND ELIMINATION

THE PROJECT AIMS TO DESIGN, DEVELOP, PROTOTYPE, AND VALIDATE A NOVEL AI-ENABLED, PHOTOACOUSTIC IMAGING (PAI) BASED WELL-LOGGING TOOL FOR COMPREHENSIVE EVALUATION OF THE INTEGRITY OF GEOTHERMAL WELLS AT HIGH TEMPERATURE AND HIGH PRESSURE WITHOUT ACTIVE COOLING. THE PROPOSED TECHNOLOGY IS A HIGH-FIDELITY COMPLETE INSPECTION TOOL THAT IS COMPATIBLE WITH CURRENT CONVEYANCE METHODS. THE NEW TOOL WILL PROVIDE THE FULL, CONTINUOUS 3D TOMOGRAPH OF WELLBORE (CASING, CEMENT, PART OF FORMATION) WITH DEFECTS IDENTIFIED, CLASSIFIED, AND DISPLAYED/OVERLAID.

COLLABORATIVE RESEARCH: STUDENT PATHWAYS IN ENGINEERING AND COMPUTING FOR TRANSFER SUCCESS

HUANGLONGBING (HLB) IS PRESENTLY THE MOST DEVASTATING CITRUS DISEASE WORLDWIDE. BECAUSE OF THE EXTENSIVE SPREAD AND A LACK OF EFFECTIVE CONTROL MEASURES FOR HLB, FLORIDA&#39;S $9 BILLION CITRUS INDUSTRY HAS EXPERIENCED A DECLINE IN PRODUCTION OF NEARLY 75%. AS A RESULT, THE INDUSTRY IS PRESENTLY FIGHTING FOR ITS SURVIVAL. THE OTHER MAJOR CITRUS STATES ARE AT HIGH RISK FOR A SIMILAR DISASTROUS SITUATION IF SUITABLE REMEDIES ARE NOT FORTHCOMING SOON. NEITHER A SIMPLE CURE NOR SUCCESSFUL MANAGEMENT STRATEGIES HAVE BEEN IDENTIFIED EVEN AFTER 10+YEARS OF THE DISEASE PRESENCE IN FLORIDA. PREVIOUS EFFORTS TO CREATE NEW HLB TOLERANT/RESISTANT CULTIVARS FOCUSED ON CONVENTIONAL BREEDING OR DEVELOPMENT OF TRANSGENIC PLANTS. UNFORTUNATELY, THE APPROACHES USED IN THOSE PROJECTS ARE INADEQUATE TO MEET THE CURRENT CRISIS BECAUSE OF THE LACK OF SOURCES OF RESISTANCE IN CITRUS AND TIME CONSTRAINTS ASSOCIATED WITH CITRUS BREEDING. FURTHERMORE, GENETIC ENGINEERING PRESENTS MANY REGULATORY AND PUBLIC ACCEPTANCE OBSTACLES FOR TRANSGENIC CITRUS. ON THE OTHER HAND, MORE THAN 10 YEARS OF HLB AND TENS OF MILLIONS OF INFECTED TREES IN GROVES ACROSS FLORIDA PROVIDE AN UNPRECEDENTED OPPORTUNITY AND HIGH PROBABILITY TO SELECT RESISTANT NATURAL MUTANTS. FIELD RESISTANCE OR TOLERANCE TO HLB HAS ALREADY BEEN NOTED AMONGST THE CITRUS CULTIVARS AND THEIR RELATIVES.THIS PROVIDES CIRCUMSTANTIAL EVIDENCE THAT NATURAL VARIATION EXISTS REGARDING HLB TOLERANCE/RESISTANCE WITHIN THE CITRUS GENE POOL.EXPLOITATION OF THIS NATURAL TOLERANCE/RESISTANCE MAY PROVIDE A KEY SOLUTION, WITHIN A SHORT TIME FRAME, TO THE SURVIVAL OF THE CITRUS INDUSTRY, ESPECIALLY IN FLORIDA.THIS PROJECT ADDRESSES THE DEVELOPMENT OF TOLERANCE OR RESISTANCE IN COMMERCIAL CITRUS IN ALL PRODUCTION AREAS WITH A FOCUS ON DELIVERY OF NEW CULTIVARS [OR ROOTSTOCKS AND SCIONS] USING ALL AVAILABLE STRATEGIES, WHICH IS ONE OF THE PRIORITIES SET FORTH BY THE CITRUS DISEASE SUB-COMMITTEE.IN THIS PROPOSAL, WE PRESENT A SYSTEMATIC APPROACH WITH EMPHASIS ON SKILLFUL SELECTION OF NATURAL MUTANTS TO DEVELOP NEW HLB TOLERANT/RESISTANCE CITRUS CULTIVARS. FIRST, WE WILL SELECT VARIANT SEEDLINGS AND BUD SPORTS WITH GREATER HLB TOLERANCE/RESISTANCE IN CITRUS GROVES ACROSS FLORIDA AND TEST THEM IN FIELD TRIALS. WITH THE OBTAINED HLB TOLERANT/RESISTANT BUD SPORTS/VARIANT SEEDLINGS AND THEIR SUSCEPTIBLE SIBLINGS, WE WILL BE ABLE TO APPLY TRANSCRIPTOME PROFILING AND COMPARATIVE GENOMICS TO IDENTIFY HLB TOLERANCE/RESISTANT OR SUSCEPTIBILITY RELATED GENES. MOREOVER, WITH THE HLB SUSCEPTIBILITY RELATED GENES IDENTIFIED IN OUR PRELIMINARY STUDY AND THIS PROJECT, WE WILL DEVELOP NEW RESISTANT VARIETIES VIA GENE EDITING USING CRISPR-CAS9 ON THE IDENTIFIED TARGET GENES. THE CRISPR ENGINEERED CITRUS PLANTS DO NOT INCLUDE FOREIGN GENES AND ARE CURRENTLY NOT RESTRICTED IN THE US. MEANWHILE, WE WILL CONDUCT ACTIVE OUTREACH AND EXTENSION TO DISSEMINATE OUR PROJECT RESULTS TO GROWERS, STAKEHOLDERS AND THE PUBLIC. THE SUCCESSFUL ACHIEVEMENT OF OUR GOALS AND OBJECTIVES WILL BROADLY IMPACT THE ENTIRE US CITRUS INDUSTRY, BY MAINTAINING THE VIABILITY OF INDUSTRIES NOT YET FULLY IMPACTED AS IN FLORIDA, AND BY PROVIDING THE PLANT MATERIALS THAT WILL ENCOURAGE FLORIDA GROWERS TO REPLANT WITH CONFIDENCE. THE COMBINED ECONOMIC IMPACTS OF OUR US CITRUS INDUSTRIES WILL BE MEASURED IN BILLIONS OF DOLLARS. THE MANY COMMUNITIES THROUGHOUT THE COUNTRY HAVING ECONOMIES BUILT AROUND VIABLE CITRUS PRODUCTION WILL AVOID THE MAJOR DISTURBANCES THAT WILL COME FROM THE ECONOMIC DISASTERS THAT HLB INCURS. CURRENT APPROACHES FOR HLB MANAGEMENT ARE BASED ON AN OVER-RELIANCE OF CHEMICAL INSECT CONTROL, AND MORE RECENTLY THE WIDESPREAD USE OF ANTIBIOTIC COMPOUNDS; THE ENVIRONMENTAL IMPACTS OF THESE PRACTICES MAY PROVE TO BE UNACCEPTABLE IN THE LONG RUN, AND RESISTANT CULTIVARS CAN MITIGATE SUCH DAMAGE. THE SELECTED CITRUS VARIETIES WITH HLB RESISTANCE/TOLERANCE ARE EXPECTED TO BE THE MOST DURABLE, ECO-FRIENDLY AND COST-EFFECTIVE SOLUTION TO THIS DEVASTATING DISEASE. THE SUCCESS OF THIS PROJECT WILL SET UP A MODEL FOR THE CITRUS COMMUNITY ACROSS THE GLOBE TO FOLLOW, AND THEREFORE SOLVE THE HLB PROBLEM.

DELPHI: SOFTWARE FOR ELECTROSTATIC MODELING OF BIOMOLECULES AND OBJECTS

NATIONAL DROPOUT CENTER

** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** HUANGLONGBING (HLB) IS THE MOST DEVASTATING DISEASE OF CITRUS IN THE U.S. ECONOMIC LOSSES OVER THE PAST FIVE YEARS IN FL ALONE AMOUNT TO OVER $1 BILLION PER YEAR, WITH NEARLY 5,000 JOBS LOST ANNUALLY. THE U.S. CITRUS INDUSTRY IS IN DIRE NEED OF NEW CITRUS CULTIVARS WITH STABLE AND BROAD-SPECTRUM RESISTANCE/TOLERANCE TO HLB AS WELL AS DESIRABLE HORTICULTURAL CHARACTERISTICS, CROP YIELD, AND FRUIT QUALITY. THE OTHER MAJOR CITRUS STATES ARE AT HIGH RISK FOR A SIMILAR DISASTROUS SITUATION IF SUITABLE REMEDIES ARE NOT FORTHCOMING SOON. NEITHER A SIMPLE CURE NOR SUCCESSFUL MANAGEMENT STRATEGIES HAVE BEEN IDENTIFIED EVEN AFTER 15+YEARS OF THE DISEASE&#39; PRESENCE IN FLORIDA.PREVIOUS EFFORTS TO CREATE NEW HLB RESISTANT/TOLERANT CULTIVARS WERE FOCUSED ON CONVENTIONAL HYBRID BREEDING OR THE DEVELOPMENT OF TRANSGENIC PLANTS. UNFORTUNATELY, THE APPROACHES USED IN THOSE PROJECTS ARE INADEQUATE TO MEET THE CURRENT CRISIS BECAUSE OF THE LACK OF SOURCES OF RESISTANCE IN CITRUS, TIME CONSTRAINTS ASSOCIATED WITH CITRUS BREEDING AND GENETIC ENGINEERING, AND REGULATORY OBSTACLES FOR TRANSGENIC CITRUS. MEANWHILE, MORE THAN 15 YEARS OF HLB EPIDEMICS AND TENS OF MILLIONS OF INFECTED TREES IN GROVES ACROSS FLORIDA PROVIDE AN UNPRECEDENTED OPPORTUNITY AND HIGH PROBABILITY FOR SELECTING NEW MUTANT SCIONS THAT ARE RESISTANT OR AT LEAST HIGHLY TOLERANT. OVER THE PAST YEARS, OUR GROUP HAS SELECTED MULTIPLE CITRUS VARIETIES WITH FIELD RESISTANCE OR TOLERANCE TO HLB FROM FLORIDA GROVES. A RECENT STUDY SHOWED THAT HLB IS A PATHOGEN-TRIGGERED IMMUNE DISEASE. THESE NATURAL VARIANTS MAY HAVE HLB RESISTANCE/TOLERANCE THROUGH EVASION OF THE IMMUNE RESPONSE OR LOSS OF SUSCEPTIBILITY GENES. ALTHOUGH THE EXPLOITATION OF NATURAL RESISTANCE/TOLERANCE PROVIDES A KEY SOLUTION TO DEVELOPING NEW HLB-RESISTANT/TOLERANT CITRUS SCIONS AND ROOTSTOCKS, IT STILL REQUIRES A SIGNIFICANT AMOUNT OF TIME TO CONFIRM STABLE RESISTANCE OF THE SELECTED VARIETIES. IT IS CRITICAL TO DEVELOP RAPID METHODS TO SHORTEN THE SELECTION PROCESS, TO PROVIDE SOLUTIONS WITHIN A SHORTER TIME FRAME TO ENSURE THE SURVIVAL OF THE CITRUS INDUSTRY, ESPECIALLY IN FLORIDA.OUR PREVIOUS RESEARCH SHOWS THAT TRANSPOSON ACTIVITIES ARE ONE OF THE IMPORTANT DRIVERS OF DIVERSIFICATION IN SWEET ORANGES. BY MONITORING THE TRANSPOSON ACTIVITIES IN SELECTED VARIETIES, WE MAY BE ABLE TO DETERMINE THEIR GENETIC STABILITY, AND THEN FACILITATE SELECTION. FURTHERMORE, THERE ARE MANY AVAILABLE SEQUENCES OF CITRUS GENOMES, INCLUDING SEVERAL HLB-RESISTANT/TOLERANT CITRUS PLANTS AND THEIR COUNTERPARTS THAT OUR GROUP AND OTHERS HAVE SEQUENCED. IT IS CRITICAL THAT WE CAN INTEGRATE ALL GENOME-BASED INFORMATION TO UNDERSTAND THE HLB-RESISTANT/TOLERANT OR SUSCEPTIBILITY-RELATED GENES. WITH MORE SEQUENCES OF HLB-RESISTANT/TOLERANT CITRUS PLANTS AND THEIR COUNTERPARTS IN THIS PROJECT, WE CAN BUILD A PANGENOME THAT INCLUDES ALL HLB-RESISTANT/TOLERANT RELATED VARIANTS. THIS SHOULD HELP IDENTIFY HLB-RESISTANT/TOLERANT OR SUSCEPTIBILITY-RELATED GENES.THIS P,ROJECT ADDRESSES THE DEVELOPMENT OF COMMERCIAL CITRUS VARIETIES (ROOTSTOCKS AND SCIONS) FOR BOTH FRESH AND PROCESSED MARKETS WITH GENETIC TOLERANCE AND RESISTANCE TO HLB USING TRADITIONAL BREEDING TECHNIQUES AND/OR GENE EDITING, WHICH IS ONE OF THE ECDRE FOCUS AREAS.IN THIS PROPOSAL, WE FIRST PRESENT A SYSTEMATIC APPROACH WITH EMPHASIS ON THE RAPID SELECTION, ASSESSMENT, AND DELIVERY OF NEW HLB-RESISTANT/TOLERANT CITRUS VARIANTS AS NEW SCION AND ROOTSTOCK CULTIVARS. SECOND, WE WILL DEVELOP A NOVEL PANGENOME TO IDENTIFY HLB RESISTANCE/TOLERANCE OR SUSCEPTIBILITY-RELATED GENES. MOREOVER, WITH THE HLB SUSCEPTIBILITY-RELATED GENES IDENTIFIED IN OUR PREVIOUS STUDY, WE WILL DEVELOP NEW VARIETIES VIA GENE EDITING USING CRISPR-CAS AND TEST THEIR RESISTANCE TO HLB. WE WILL CONDUCT MULTISTATE FIELD TRAILS OF OUR PREVIOUS SELECTED VARIETIES AND EVALUATE THEIR HORTICULTURAL PERFORMANCE AND ECONOMIC IMPACTS. MEANWHILE, WE WILL CONDUCT ACTIVE OUTREACH AND EXTENSION TO DISSEMINATE OUR PROJECT RESULTS TO GROWERS, STAKEHOLDERS, AND THE PUBLIC.OUR PRACTICAL METHODS FOR RAPIDLY SELECTING, ASSESSING, AND DELIVERING STABLE AND BROAD-SPECTRUM HLB-RESISTANT/TOLERANT CITRUS VARIANTS WILL ALLOW HLB-RESISTANT/TOLERANT SCION AND ROOTSTOCK CULTIVARS TO BE DEVELOPED AND DEPLOYED MUCH QUICKER WITHOUT REGULATORY CONSTRAINTS. THE INTEGRATED CITRUS PANGENOME CAN HELP IDENTIFY THE GENETIC ELEMENTS ASSOCIATED WITH HLB RESISTANCE/TOLERANCE OR SUSCEPTIBILITY. THE IDENTIFIED HLB RESISTANCE/ TOLERANCE OR SUSCEPTIBILITY RELATED GENES WILL PROVIDE A FOUNDATION FOR UNDERSTANDING THE MOLECULAR MECHANISMS OF LAS INFECTION AND HLB SYMPTOM PROGRESSION. PRECISE GENE EDITING BASED ON THE CRISPR SYSTEM WILL ENABLE TARGETED DISRUPTION OF CITRUS GENES THAT ARE ESSENTIAL TO LAS INFECTION, MULTIPLICATION, AND PATHOGENESIS, PRODUCTION OF LOSS-OF-FUNCTION MUTANTS, AND DEVELOPMENT OF NEW HLB RESISTANT/TOLERANT CITRUS CULTIVARS THAT ARE FREE OF GMO FINGERPRINTS AND POTENTIALLY FREE OF REGULATORY OBSTACLES TO THE MARKET.HORTICULTURE AND SOCIO-ECONOMICS-BASED SUPPORT TOOLS WILL BE DEVELOPED FOR THE INDUSTRY TO ADOPT NEW CULTIVARS WITH CONFIDENCE. THE SELECTED CITRUS VARIETIES WITH HLB RESISTANCE/TOLERANCE ARE EXPECTED TO BE THE MOST DURABLE, ECO-FRIENDLY, AND COST-EFFECTIVE SOLUTION TO THIS DEVASTATING DISEASE.THE SUCCESSFUL ACHIEVEMENT OF OUR GOALS AND OBJECTIVES WILL BROADLY IMPACT THE ENTIRE US CITRUS INDUSTRY, BY MAINTAINING THE VIABILITY OF INDUSTRIES NOT YET FULLY IMPACTED AS IN FLORIDA, AND BY PROVIDING THE PLANT MATERIALS THAT WILL ENCOURAGE FLORIDA GROWERS TO REPLANT WITH CONFIDENCE. THE COMBINED ECONOMIC IMPACTS OF OUR US CITRUS INDUSTRIES WILL BE MEASURED IN BILLIONS OF DOLLARS. THE MANY COMMUNITIES THROUGHOUT THE COUNTRY HAVING ECONOMIES BUILT AROUND VIABLE CITRUS PRODUCTION WILL AVOID THE MAJOR DISTURBANCES THAT WILL COME FROM THE ECONOMIC DISASTERS THAT HLB INCURS. THE SUCCESS OF THIS PROJECT WILL SET UP A MODEL FOR THE CITRUS COMMUNITY ACROSS THE GLOBE TO FOLLOW AND SOLVE THE HLB PROBLEMS,IN THE NOT-TOO-DISTANT FUTURE.

THERANOSTIC APPROACH TO TREAT ABDOMINAL AORTIC ANEURYSMS

THE CENTER FOR AVIATION AND AUTOMOTIVE TECHNOLOGICAL EDUCATION USING E-LEARNING: PROVIDING E-LEARNING RESOURCES AND INCREASING KNOWLEDGE ABOUT THEIR EFFECTIVENESS

WHWC'S APPLICATION FOR CCBHC FUNDS. - THE “LAUNCHING CCBHC SERVICES IN MINGO COUNTY, WV” PROJECT WILL BE LED BY WILLIAMSON HEALTH & WELLNESS CENTER, A FEDERALLY QUALIFIED HEALTH CENTER, THAT OFFERS INTEGRATED PRIMARY CARE SERVICES. MINGO COUNTY IS PRIMARILY RURAL AND IS HOME TO THE LARGEST COAL MARSHALING YARDS IN THE WORLD, LEAVING BEHIND ONE OF THE POOREST AND UNHEALTHIEST U.S. REGIONS AS COAL PRODUCTION HAS DECLINED. THE PROJECT WILL SERVE 1,400 INDIVIDUALS TOTAL (600 IN YEAR ONE, 800 IN YEAR TWO). THE NEW CCBHC WILL SUPPORT THE EXPANSION OF MAT/SUD SERVICES, INCREASED PSYCHIATRIC ASSESSMENT AND TREATMENT CAPACITY, INTEGRATION OF PRIMARY CARE-BEHAVIORAL HEALTH CLINICS, PROVISION OF A 24/7 CRISIS MANAGEMENT TEAM, LAUNCH OF A SUD CARE HOME-VISITING TEAM THAT INCLUDES TRANSPORTATION ASSISTANCE, EXPANSION OF PEER SUPPORT AND CASE MANAGEMENT PATIENTCENTERED SERVICES, EXPANSION OF ACT REFERRALS TO DESIGNATED COLLABORATIVE ORGANIZATION, AND BUILD OUT OF AN INTEGRATED YOUTH BEHAVIORAL HEALTH CARE PROGRAM. POPULATIONS OF FOCUS INCLUDE ADULTS AND YOUTH EXPERIENCING MENTAL HEALTH CONDITIONS, TO INCLUDE SERIOUS MENTAL ILLNESS (SMI) AND SERIOUS EMOTIONAL DISTURBANCE (SED), AND INDIVIDUALS EXPERIENCING SUBSTANCE USE DISORDERS (SUD), WITH TARGETED OUTREACH TO VETERANS. IN MINGO COUNTY, ALMOST HALF OF NON-FARM PAYROLL EMPLOYMENT HAS BEEN LOST IN THE PAST 7 YEARS, UNEMPLOYMENT IS DOUBLE THE NATIONAL RATE, AND MORE THAN ONE IN FOUR INDIVIDUALS ARE EXPERIENCING POVERTY. MINGO COUNTY IS LOCATED IN THE HEART OF AMERICA’S OPIOID CRISIS AND HAS A DRUG OVERDOSE RATE OF 63 DEATHS PER 100,000 RESIDENTS - THE TENTH HIGHEST RATE IN WV (2020 COUNTY HEALTH RANKINGS). MINGO COUNTY’S DRUG OVERDOSE DEATH RATE IS 22% HIGHER THAN WV’S RATE AND 3 TIMES GREATER THAN THE U.S. RATE IN A STATE THAT HAS THE HIGHEST DRUG OVERDOSE RATE (CDC). WV RESIDENTS EXPERIENCE A SIGNIFICANTLY HIGH RATE OF SMI AT 6.1%, COMPARED TO THE REGION (4.5%) AND NATION (4.8%) (SAMHSA). NATIONALLY, SED IS EXPERIENCED BY 10% OF YOUTH AND ADOLESCENTS (PSYCHIATRY ONLINE ARTICLE, 9/1/17). WHWC HAS OUTLINED THREE PROJECT GOALS: GOAL 1) EXPAND ACCESS TO COMPREHENSIVE OUTPATIENT BEHAVIORAL HEALTH SERVICES, INCLUDING PSYCHIATRIC AND MAT/SUD TREATMENT, THROUGH EXPANDED CCBHC STAFFING MODEL THAT RESULTS IN REDUCED BARRIERS TO CARE; 2) IMPROVE BEHAVIORAL HEALTH OUTCOMES AMONG POPULATIONS OF FOCUS WITH MH/SUD ISSUES THROUGH INTEGRATED CCBHC EXPANSION EFFORTS; AND 3) STRENGTHEN CAPACITY OF WHWC WORKFORCE TO PROVIDE QUALITY FAMILY- AND PATIENT-CENTERED CARE THROUGH TRAININGS OFFERED AND EVIDENCE-BASED PRACTICES. KEY HEALTH OUTCOME OBJECTIVES INCLUDE A 15% REDUCTION IN MISSED APPOINTMENTS, 30% REDUCTION OF PSYCHIATRIC HOSPITALIZATIONS, 30% REDUCTION IN SUBSTANCE USE, 80% IMPROVEMENT IN LIFE FUNCTIONING, AND 25% IMPROVEMENT IN MENTAL HEALTH FUNCTIONING. PLANNED EVIDENCE-BASED PRACTICES INCLUDE MOTIVATIONAL INTERVIEWING/ENHANCEMENT, COGNITIVE BEHAVIORAL THERAPY (CBT), TRAUMA-INFORMED CARE, MEDICATION-ASSISTED TREATMENT, PEER SUPPORT SPECIALISTS, TRAUMA-FOCUSED CBT, PARENT-CHILD INTERACTION THERAPY-INFORMED TREATMENT, AND EYE MOVEMENT DESENSITIZATION AND REPROCESSING.

PROCESS AND EQUIPMENT DEVELOPMENT PROGRAM FOR PLUTONIUM DISPOSITION

REALIZING IMPROVED PATIENT CARE THROUGH HUMAN-CENTERED DESIGN IN THE OR

APPLICATION PURPOSE: WITH THIS GRANT CAT WILL REPLACE 3 AGING DIESEL BUSES WITH ZERO EMISSION ELECTRIC BUSES AND WILL ADD 3 DUAL DEPOT CHARGERS.; ACTIVITIES PERFORMED: CAT WILL ADD 3 DUAL DEPOT CHARGERS AND REPLACE 3 DIESEL BUSES.; EXPECTED OUTCOMES: FUNDING WILL ALLOW CAT TO REDUCE GREENHOUSE GASES BY REMOVING DIESEL BUSES FROM SERVICE.; INTENDED BENEFICIARIES: ALL RIDERS AND DRIVERS WILL BENEFIT.; SUBRECIPIENT ACTIVITIES: NONE

NURSE EDUCATION, PRACTICE, QUALITY AND RETENTION

CLEMSON AREA TRANSIT LONO GRANT FY 2016

HIGH POWER FIBER LASERS

CLEMSON UNIVERSITY CYBERINSTITUTE

1. AWARD PURPOSE: THE PURPOSE OF THIS AGREEMENT IS TO CONDUCT SURVEY, REGULATORY, OUTREACH, AND TREE REMOVAL OPERATIONS IN SUPPORT OF THE ASIAN LONGHORNED BEETLE- ALB (ANOPLOPHORA GLABRIPENNIS) ERADICATION PROGRAM IN CHARLESTON AND DORCHESTER COUNTIES. 2. ACTIVITIES TO BE PERFORMED: COMPREHENSIVE DELIMITATION AND DETECTION SURVEYS THROUGHOUT THE ALB REGULATED AREA, TO BE CONDUCTED PRIMARILY BY CONTRACTED SURVEY PERSONNEL ADMINISTERED BY CLEMON DEPARTMENT OF PLANT INDUSTRY. ESTIMATING APPROXIMATELY 2,606 ACRES TO BE SURVEYED BY CONTRACT STAFF DURING THE PERFORMANCE PERIOD. OUTREACH AND EDUCATION EFFORTS, AT LEAST 14 EVENTS DURING THE PERFORMANCE PERIOD, THROUGHOUT THE STATE TO GAIN SUPPORT FROM INDUSTRY GROUPS, THE GENERAL PUBLIC, AND OTHER AFFECTED STAKEHOLDERS. REGULATORY OPERATIONS TO INCLUDE ISSUANCE OF COMPLIANCE AGREEMENTS, COMPLIANCE TRAININGS AND MONITORING, STATE-WIDE SURVEYS, AND ENFORCEMENT OF THE REGULATIONS. ASSIST AND SUPPORT OPERATIONS TO REMOVE INFESTED AND HIGH-RISK HOST TREES, AND DEREGULATE REGULATED MATERIAL. 3. DELIVERABLES AND EXPECTED OUTCOMES: EXPECTED OUTCOMES ARE THE CONTAINMENT AND EVENTUAL ERADICATION OF ASIAN LONGHORNED BEETLE FROM SOUTH CAROLINA. ALL DATA PERTAINING TO ALB SURVEY AND TREE REMOVAL ACTIVITIES WILL BE COLLECTED IN APHIS-APPROVED GEOSPATIAL MOBILE DATA COLLECTION APPLICATIONS AND HOSTED IN THE APHIS GIS PORTAL. 4. INTENDED BENEFICIARY(IES): SOUTH CAROLINA FORESTRY AND GREEN INDUSTRY STAKEHOLDERS, AND THE GENERAL PUBLIC. 5. SUBRECIPIENT ACTIVITIES, IF KNOWN OR SPECIFIED AT THE TIME OF AWARD: NONE.

INTENSIVE MODELS OF HCV CARE FOR INJECTION DRUG USERS

FW-HTF-T/COLLABORATIVE RESEARCH: OCCUPATIONAL EXOSKELETONS AND THE HUMAN-TECHNOLOGY PARTNERSHIP: ACHIEVING SCALE AND INTEGRATION INTO THE FUTURE OF WORK

CENTER FOR AVIATION AND AUTOMOTIVE TECHNOLOGICAL EDUCATION USING VIRTUAL E-SCHOOL [CA2VES]: A RESOURCE TO MEET TECHNICIAN WORKFORCE NEEDS

AGRICULTURE IS THE PRIMARY INDUSTRY IN SOUTH CAROLINA, WITH 25,000 FARMS ACROSS 4.7 MILLION ACRES THAT CONTRIBUTE OVER $46 BILLION TO THE STATE'S ANNUAL ECONOMY AND PROVIDES OVER 247,000 JOBS. FORESTRY IS ALSO AN IMPORTANT ECONOMIC DRIVER IN SC, CONTRIBUTING OVER $21.2 BILLION ANNUALLY. WITH DIVERSE NATURAL RESOURCES ACROSS THE STATE, TOURISM IS AN ADDITIONAL ECONOMIC FORCE, ACCOUNTING FOR EXPENDITURES OF $24.4 BILLION IN 2019. SUPPORTING AND IMPROVING THE LIVELIHOOD AND QUALITY OF LIFE FOR SC RESIDENTS ARE WHAT DRIVE THE PROGRAMMING AND RESEARCH FOCUS FOR CLEMSON UNIVERSITY. THE PLAN OF WORK REFLECTS RESEARCH ACTIVITIES TO BENEFIT AGRIBUSINESS, COMMUNITIES, AND CITIZENS OF SC. THE RESEARCH IS CONDUCTED ON THE MAIN CAMPUS OF CLEMSON UNIVERSITY AND IN EACH OF THE SIX RESEARCH AND EDUCATION CENTERS (RECS) LOCATED ACROSS THE STATE. FOCUS AREAS INCLUDE ADVANCING THE COMPETITIVENESS OF THE AGRICULTURE AND FORESTRY, ECONOMIC DEVELOPMENT, SAFEGUARDING THE FOOD SUPPLY, PRESERVING NATURAL RESOURCES, AND PREPARING YOUNGER GENERATIONS TO BECOME PRODUCTIVE CITIZENS. RESEARCH TO IMPROVE THE PRODUCTIVITY AND PROFITABILITY OF AGRICULTURAL SYSTEMS INCLUDES OUR ADVANCED PLANT TECHNOLOGY (APT) PROGRAM AND OUR PRECISION AGRICULTURE PROGRAM. THE APT PROGRAM USES TRADITIONAL PLANT BREEDING AND MOLECULAR GENETICS TO DEVELOP NEW CROPS AND CROP-BASED PRODUCTS. THE PRECISION AGRICULTURE PROGRAM DEVELOPS DEVICES AND METHODOLOGIES FOR SITE-SPECIFIC AND MORE EFFICIENT USE OF INPUTS (E.G., WATER, FERTILIZER, PESTICIDES). OTHER RESEARCH EFFORTS STUDY LIVESTOCK FORAGE PRODUCTION TO ENHANCE FARM PROFITS AND ENVIRONMENTAL SUSTAINABILITY. RESEARCH ACTIVITIES SPECIFIC TO THE MAJOR AGRONOMIC AND SPECIALTY CROPS FOCUS ON REDUCTION OF COSTS TO MANAGE WEEDS, DISEASES AND INSECT PESTS. LIKEWISE, INVESTIGATORS ARE DEVELOPING IMPROVEMENTS TO IRRIGATION WATER MANAGEMENT USING REAL-TIME SOIL AND WEATHER INPUTS. RESEARCH PROGRAMS TO SUSTAIN CONSERVATION OF NATURAL RESOURCES INCLUDE: 1) REMOTE CLIMATIC DATA COLLECTION AND DATA MANAGEMENT ON FORESTS, 2) TECHNIQUES TO ENHANCE FOREST GROWTH AND QUALITY (SILVICULTURE, HARVESTING OPERATIONS, FOREST MANAGEMENT, AND FOREST HEALTH), 3) HYDROLOGIC AND FOREST PRODUCTIVITY PROCESSES ALONG HYDROPERIODS AND SALINITY GRADIENTS. RESEARCH IN FOOD SAFETY, SECURITY AND NUTRITION FOCUSES ON 1) EFFECTIVENESS OF RENDERING AND POST-PROCESS STORAGE CONDITIONS TO PREV ENT THE GROWTH OF ANIMAL DISEASE PATHOGENS, 2) DEVELOPMENT OF RAPID DETECTION METHODS FOR FOOD CONTAMINANTS, 3) IMPROVEMENTS IN PACKAGING TO ENHANCE FOOD SAFETY AND FOOD QUALITY AND REDUCING FOOD WASTE.

THE HATCH ACT OF 1887 (REGULAR RESEARCH) - CLEMSON UNIVERSITY

THE NEXT GENERATION SOLID STATE POWER CONVERSION MATERIALS

AGRICULTURE IS THE PRIMARY INDUSTRY IN SOUTH CAROLINA, WITH 25,000 FARMS ACROSS 4.7 MILLION ACRES THAT CONTRIBUTE OVER $46 BILLION TO THE STATE'S ANNUAL ECONOMY AND PROVIDES OVER 247,000 JOBS. FORESTRY IS ALSO AN IMPORTANT ECONOMIC DRIVER IN SC, CONTRIBUTING OVER $21.2 BILLION ANNUALLY. WITH DIVERSE NATURAL RESOURCES ACROSS THE STATE, TOURISM IS AN ADDITIONAL ECONOMIC FORCE, ACCOUNTING FOR EXPENDITURES OF $24.4 BILLION IN 2019. SUPPORTING AND IMPROVING THE LIVELIHOOD AND QUALITY OF LIFE FOR SC RESIDENTS ARE WHAT DRIVE THE PROGRAMMING AND RESEARCH FOCUS FOR CLEMSON UNIVERSITY. THE PLAN OF WORK REFLECTS RESEARCH ACTIVITIES TO BENEFIT AGRIBUSINESS, COMMUNITIES, AND CITIZENS OF SC. THE RESEARCH IS CONDUCTED ON THE MAIN CAMPUS OF CLEMSON UNIVERSITY AND IN EACH OF THE SIX RESEARCH AND EDUCATION CENTERS (RECS) LOCATED ACROSS THE STATE. FOCUS AREAS INCLUDE ADVANCING THE COMPETITIVENESS OF THE AGRICULTURE AND FORESTRY, ECONOMIC DEVELOPMENT, SAFEGUARDING THE FOOD SUPPLY, PRESERVING NATURAL RESOURCES, AND PREPARING YOUNGER GENERATIONS TO BECOME PRODU CTIVE CITIZENS. RESEARCH TO IMPROVE THE PRODUCTIVITY AND PROFITABILITY OF AGRICULTURAL SYSTEMS INCLUDES OUR ADVANCED PLANT TECHNOLOGY (APT) PROGRAM AND OUR PRECISION AGRICULTURE PROGRAM. THE APT PROGRAM USES TRADITIONAL PLANT BREEDING AND MOLECULAR GENETICS TO DEV ELOP NEW CROPS AND CROP-BASED PRODUCTS. THE PRECISION AGRICULTURE PROGRAM DEVELOPS DEVICES AND METHODOLOGIES FOR SITE-SPECIFIC AND MORE EFFICIENT USE OF INPUTS (E.G., WATER, FERTILIZER, PESTICIDES). OTHER RESEARCH EFFORTS STUDY LIVESTOCK FORAGE PRODUCTION TO ENHANCE FARM PROFITS AND ENVIRONMENTAL SUSTAINABILITY. RESEARCH ACTIVITIES SPECIFIC TO THE MAJOR AGRONOMIC AND SPECIALTY CROPS FOCUS ON REDUCTION OF COSTS TO MANAGE WEEDS, DISEASES AND INSECT PESTS. LIKEWISE, INVESTIGATORS ARE DEVELOPING IMPROVEMENTS TO IRRIGATION WATER MANAGEMENT USING REAL-TIME SOIL AND WEATHER INPUTS. RESEARCH PROGRAMS TO SUSTAIN CONSERVATION OF NATURAL RESOURCES INCLUDE: 1) REMOTE CLIMATIC DATA COLLECTION AND DATA MANAGEMENT ON FORESTS, 2) TECHNIQUES TO ENHANCE FOREST GROWTH AND QUALITY (SILVICULTURE, HARVESTING OPERATIONS, FOREST MANAGEMENT, AND FOREST HEALTH), 3) HYDROLOGIC AND FOREST PRODUCTIVITY PROCESSES ALONG HYDROPERIODS AND SALINITY GRADIENTS. RESEARCH IN FOOD SAFETY, SECURITY AND NUTRITION FOCUSES ON 1) EFFECTIVENESS OF RENDERING AND POST-PROCESS STORAGE CONDITIONS TO PREVENT THE GROWTH OF ANIMAL DISEASE PATHOGENS, 2) DEVELOPMENT OF RAPID DETECTION METHODS FOR FOOD CONTAMINANTS, 3) IMPR OVEMENTS IN PACKAGING TO ENHANCE FOOD SAFETY AND FOOD QUALITY AND REDUCING FOOD WASTE.

CLEMSON UNIVERSITY - FY20 HATCH REGULAR

CLEMSON UNIVERSITY - FY22 HATCH REGULAR

AGRICULTURE IS THE PRIMARY INDUSTRY IN SOUTH CAROLINA, WITH 25,000 FARMS ACROSS 4.7 MILLION ACRES THAT CONTRIBUTE OVER $46 BILLION TO THE STATE'S ANNUAL ECONOMY AND PROVIDE OVER 247,000 JOBS. FORESTRY IS ALSO AN IMPORTANT ECONOMIC DRIVER IN SC, CONTRIBUTING OVER $21.2 BILLION ANNUALLY. WITH DIVERSE NATURAL RESOURCES ACROSS THE STATE, TOURISM IS AN ADDITIONAL ECONOMIC FORCE, ACCOUNTING FOR EXPENDITURES OF $24.4 BILLION ANNUALLY. SUPPORTING AND IMPROVING THE LIVELIHOOD AND QUALITY OF LIFE FOR SC RESIDENTS ARE WHAT DRIVE THE PROGRAMMING AND RESEARCH FOCUS FOR CLEMSON UNIVERSITY. THE PLAN OF WORK REFLECTS RESEARCH ACTIVITIES TO BENEFIT AGRIBUSINESS, COMMUNITIES, AND CITIZENS OF SC. THE RESEARCH IS CONDUCTED ON THE MAIN CAMPUS OF CLEMSON UNIVERSITY AND IN EACH OF THE SIX RESEARCH AND EDUCATION CENTERS (RECS) LOCATED ACROSS THE STATE. FOCUS AREAS INCLUDE ADVANCING THE COMPETITIVENESS OF THE AGRICULTURE AND FORESTRY, ECONOMIC DEVELOPMENT, SAFEGUARDING THE FOOD SUPPLY, PRESERVING NATURAL RESOURCES, AND PREPARING YOUNGER GENERATIONS TO BECOME PRODU CTIVE CITIZENS. RESEARCH TO IMPROVE THE PRODUCTIVITY AND PROFITABILITY OF AGRICULTURAL SYSTEMS INCLUDES OUR ADVANCED PLANT TECHNOLOGY (APT) PROGRAM AND OUR PRECISION AGRICULTURE PROGRAM. THE APT PROGRAM USES TRADITIONAL PLANT BREEDING AND MOLECULAR GENETICS TO DEV ELOP NEW CROPS AND CROP-BASED PRODUCTS. THE PRECISION AGRICULTURE PROGRAM DEVELOPS DEVICES AND METHODOLOGIES FOR SITE-SPECIFIC AND MORE EFFICIENT USE OF INPUTS (E.G., WATER, FERTILIZER, PESTICIDES). OTHER RESEARCH EFFORTS STUDY LIVESTOCK FORAGE PRODUCTION TO ENHANCE FARM PROFITS AND ENVIRONMENTAL SUSTAINABILITY. RESEARCH ACTIVITIES SPECIFIC TO THE MAJOR AGRONOMIC AND SPECIALTY CROPS FOCUS ON REDUCTION OF COSTS TO MANAGE WEEDS, DISEASES AND INSECT PESTS. LIKEWISE, INVESTIGATORS ARE DEVELOPING IMPROVEMENTS TO IRRIGATION WATER MANAGEMENT USING REAL-TIME SOIL AND WEATHER INPUTS. RESEARCH PROGRAMS TO SUSTAIN CONSERVATION OF NATURAL RESOURCES INCLUDE: 1) REMOTE CLIMATIC DATA COLLECTION AND DATA MANAGEMENT ON FORESTS, 2) TECHNIQUES TO ENHANCE FOREST GROWTH AND QUALITY (SILVICULTURE, HARVESTING OPERATIONS, FOREST MANAGEMENT, AND FOREST HEALTH), 3) HYDROLOGIC AND FOREST PRODUCTIVITY PROCESSES ALONG HYDROPERIODS AND SALINITY GRADIENTS. RESEARCH IN FOOD SAFETY, SECURITY AND NUTRITION FOCUSES ON 1) EFFECTIVENESS OF RENDERING AND POST-PROCESS STORAGE CONDITIONS TO PREVENT THE GROWTH OF ANIMAL DISEASE PATHOGENS, 2) DEVELOPMENT OF RAPID DETECTION METHODS FOR FOOD CONTAMINANTS, 3) IMPR OVEMENTS IN PACKAGING TO ENHANCE FOOD SAFETY AND FOOD QUALITY AND REDUCING FOOD WASTE.

CLEMSON UNIVERSITY - FY21 HATCH REGULAR

AGRICULTURE IS THE PRIMARY INDUSTRY IN SOUTH CAROLINA, WITH 25,000 FARMS ACROSS 4.7 MILLION ACRES THAT CONTRIBUTE OVER $46 BILLION TO THE STATE'S ANNUAL ECONOMY AND PROVIDE OVER 247,000 JOBS. FORESTRY IS ALSO AN IMPORTANT ECONOMIC DRIVER IN SC, CONTRIBUTING OVER $21.2 BILLION ANNUALLY. WITH DIVERSE NATURAL RESOURCES ACROSS THE STATE, TOURISM IS AN ADDITIONAL ECONOMIC FORCE, ACCOUNTING FOR EXPENDITURES OF $24.4 BILLION ANNUALLY. SUPPORTING AND IMPROVING THE LIVELIHOOD AND QUALITY OF LIFE FOR SC RESIDENTS ARE WHAT DRIVE THE PROGRAMMING AND RESEARCH FOCUS FOR CLEMSON UNIVERSITY. THE PLAN OF WORK REFLECTS RESEARCH ACTIVITIES TO BENEFIT AGRIBUSINESS, COMMUNITIES, AND CITIZENS OF SC. THE RESEARCH IS CONDUCTED ON THE MAIN CAMPUS OF CLEMSON UNIVERSITY AND IN EACH OF THE SIX RESEARCH AND EDUCATION CENTERS (RECS) LOCATED ACROSS THE STATE. FOCUS AREAS INCLUDE ADVANCING THE COMPETITIVENESS OF THE AGRICULTURE AND FORESTRY, ECONOMIC DEVELOPMENT, SAFEGUARDING THE FOOD SUPPLY, PRESERVING NATURAL RESOURCES, AND PREPARING YOUNGER GENERATIONS TO BECOME PRODU CTIVE CITIZENS. RESEARCH TO IMPROVE THE PRODUCTIVITY AND PROFITABILITY OF AGRICULTURAL SYSTEMS INCLUDES OUR ADVANCED PLANT TECHNOLOGY (APT) PROGRAM AND OUR PRECISION AGRICULTURE PROGRAM. THE APT PROGRAM USES TRADITIONAL PLANT BREEDING AND MOLECULAR GENETICS TO DEV ELOP NEW CROPS AND CROP-BASED PRODUCTS. THE PRECISION AGRICULTURE PROGRAM DEVELOPS DEVICES AND METHODOLOGIES FOR SITE-SPECIFIC AND MORE EFFICIENT USE OF INPUTS (E.G., WATER, FERTILIZER, PESTICIDES). RESEARCH ACTIVITIES SPECIFIC TO THE MAJOR AGRONOMIC AND SPECIALTY CROPS FOCUS ON REDUCTION OF COSTS TO MANAGE WEEDS, DISEASES AND INSECT PESTS. LIKEWISE, INVESTIGATORS ARE DEVELOPING IMPROVEMENTS TO IRRIGATION WATER MANAGEMENT USING REALTIME SOIL AND WEATHER INPUTS. RESEARCH PROGRAMS TO SUSTAIN CONSERVATION OF NATURAL RESOURCES INCLUDE: 1) REMOTE CLIMATIC DATA COLLECTION AND DATA MANAGEMENT ON FORESTS, 2) TECHNIQUES TO ENHANCE FOREST GROWTH AND QUALITY (SILVICULTURE, HARVESTING OPERATIONS, FOREST MANAGEMENT, AND FOREST HEALTH), 3) HYDROLOGIC AND FOREST PRODUCTIVITY PROCESSES ALONG HYDROPERIODS AND SALINITY GRADIENTS. RESEARCH IN FOOD SAFETY, SECURITY AND NUTRITION FOCUSES ON 1) EFFECTIVENESS OF RENDERING AND POST-PROCESS STORAGE CONDITIONS TO PREVENT THE GROWTH OF ANIMAL DISEASE PATHOGENS, 2) DEVELOPMENT OF RAPID DETECTION METHODS FOR FOOD CONTAMINANTS, 3) IMPROVEMENTS IN PACKAGING TO ENHANCE FOOD SAFETY AND FOOD QUALITY AND REDUCING FOOD WASTE.

THE EMERGENCE OF GUAVA ROOT-KNOT NEMATODE (GRKN,MELOIDOGYNE ENTEROLOBII), A HIGHLY VIRULENT ROOT-KNOT NEMATODE (RKN) SPECIES, IS POTENTIALLY DEVASTATING TO SPECIALTY CROP PRODUCTION IN THE SOUTHEASTERN UNITED STATES. THIS PEST CAUSES SIGNIFICANT LOSSES IN YIELD AND QUALITY, AND ITS QUARANTINED STATUS JEOPARDIZES BOTH INTERSTATE AND INTERNATIONAL TRADE. A MAJOR CONCERN IS THE ABILITY OF GRKN TO INFECT AND DAMAGE CROP GENOTYPES THAT ARE RESISTANT TO THE OTHER MAJOR SPECIES OF RKN, INCLUDING SWEETPOTATO, CUCUMBER, WATERMELON AND TOMATO. NEW RESOURCES AND INFORMATION ARE URGENTLY NEEDED TO HELP FARMERS MANAGE THIS AGGRESSIVE AND POLYPHAGOUS PEST. OUR GOAL IS TO REDUCE THE VULNERABILITY OF GROWERS TO THE EMERGING AGRICULTURAL THREAT POSED BY GRKN. OUR INTERDISCIPLINARY TEAM WILL ACHIEVE THIS GOAL USING A SYSTEMS-BASED APPROACH INVOLVING FIVE INTERCONNECTED RESEARCH AND EXTENSION OBJECTIVES: 1) STUDY THE PREVALENCE AND DISTRIBUTION OF GRKN IN VEGETABLE CROPS IN THE SOUTHEAST, AND CHARACTERIZE THE GENETIC VARIABILITY ENCOUNTERED; 2) EVALUATE AND DEVELOP VEGETABLE GERMPLASM WITH RESISTANCE AGAINST GRKN; 3) EVALUATE THE EFFICACY OF NEMATICIDES, COVER CROPS, AND ROTATIONS AS MANAGEMENT STRATEGIES FOR GRKN; 4) ASSESS THE COSTS AND RETURNS OF ROTATIONS, COVER CROPS, AND NEMATICIDES FOR THE MANAGEMENT OF GRKN ON SWEETPOTATO, CUCUMBER, WATERMELON AND TOMATO CROPS; 5) DEVELOP PRINT AND WEB-BASED EDUCATIONAL MATERIALS ON MANAGEMENT AND CONTAINMENT STRATEGIES FOR GRKN. OUR PROPOSAL CONTRIBUTES TO THE FOLLOWING PROGRAM GOALS: IDENTIFYING AND ADDRESSING THREATS FROM PESTS AND DISEASES; AND RESEARCH ON PLANT BREEDING, GENETICS, AND GENOMICS FOR PEST AND DISEASE MANAGEMENT.

ADVANCE INSTITUTIONAL TRANSFORMATION AT CLEMSON UNIVERSITY

ADVANCED OPTICAL FIBERS FOR HIGH POWER FIBER LASERS

THE HATCH ACT OF 1887 (REGULAR RESEARCH) - CLEMSON UNIVERSITY

THE HATCH ACT OF 1887 (REGULAR RESEARCH) - CLEMSON UNIVERSITY

THE HATCH ACT OF 1887 (REGULAR RESEARCH) - CLEMSON UNIVERSITY

THE HATCH ACT OF 1887 (REGULAR RESEARCH) - CLEMSON UNIVERSIT

COOPERATIVE EXTENSION PROGRAMS AT 1862 LAND-GRANT INSTITUTIONS - CLEMSON UNIVERSITY

CARES ACT SEC 5307: OPS. AND CAPITAL; CLEMSON AREA TRANSIT; GREENVILLE UZA SC

MEGAWATT SCALE, MULTI-SOURCE HEAT RECOVERY SYSTEM WITH A FLEXIBLE GRID INTERCONNECT

CLEMSON UNIVERSITY’S STEM TEACHER LEARNING PROGRESSION (CU-TLP)

HATCH ACT OF 1887 (REGULAR RESEARCH) - CLEMSON UNIVERSITY

TAS::89 0240::TAS RESEARCH SUPPORT TO BUILD AND TEST COMPONENTS OF THE PDC DESIGN, COLLECT DATA, WRITE REPORTS, MAKE DESIGN OBSERVATIONS

EARLY HEAD START ARRA EXPANSION

A RESEARCH, EDUCATIONAL, AND TECHNOLOGY TRANSFER PROGRAM FOR THE U.S. TEXTILE INDUSTRY.

CLEAN WATER3 - REDUCE, REMEDIATE, RECYCLE: INFORMED DECISION MAKING TO FACILITATE USE OF ALTERNATIVE WATER RESOURCES AND PROMOTE SUSTAINABLE SPECIALTY

HEALTH EXTENSION FOR DIABETES: PROGRAM EXPANSION TO ADVANCE HEALTH EQUITY?? - HEALTH EXTENSION FOR DIABETES: PROGRAM EXPANSION TO ADVANCE HEALTH EQUITY¿¿

NRT-AI: HARNESSING AI FOR INVERSE DESIGN TRAINING IN ADVANCED AND SUSTAINABLE COMPOSITES (IDEAS COMPOSITES) -DESPITE THE VAST DESIGN SPACE OF COMPOSITES, THERE ARE SIGNIFICANT GAPS BETWEEN THE PERFORMANCE, ECONOMIC, AND ENVIRONMENTAL TARGETS AND CURRENT DESIGN AND MANUFACTURING APPROACHES. MOST EGREGIOUS ARE THE EXPENSIVE, LONG DEVELOPMENT CYCLES AND THE SUB-OPTIMAL DESIGN THAT WASTE RESOURCES AND MAY ADVERSELY AFFECT THE ENVIRONMENT AND CLIMATE CHANGE. THE FUNDAMENTAL CAUSE OF SUCH GAPS IS THE LACK OF DETAILED UNDERSTANDING OF THE INFLUENCE OF THE MATERIAL ARCHITECTURE, PROCESS METHODS, AND PARAMETERS ON MATERIAL MICROSTRUCTURE EVOLUTION AND SUBSEQUENTLY THE END PRODUCT?S PHYSICAL, ECONOMIC, AND ENVIRONMENTAL PERFORMANCE. THIS NATIONAL SCIENCE FOUNDATION RESEARCH TRAINEESHIP (NRT), HARNESSING ARTIFICIAL INTELLIGENCE (AI) FOR INVERSE DESIGN TRAINING IN ADVANCED AND SUSTAINABLE COMPOSITES (IDEAS), WILL TRAIN STUDENTS THROUGH A PHYSICS-INFORMED, AI-BASED MODELING AND DESIGN PLATFORM WHICH WILL ENABLE THE DISCOVERY OF NEW COMPOSITES MATERIALS FORMS AND RELEVANT NEW MANUFACTURING METHODOLOGIES. THIS NRT AWARD TO CLEMSON UNIVERSITY WILL CATALYZE A SHIFT IN THE RESEARCH AND DISCOVERY PATHWAY OF THE TRAINEES VIA A TRANSFORMATIVE AI-AGE CURRICULUM CO-INSTRUCTED BY ACADEMIC FACULTY AND INDUSTRY RESEARCHERS. THE IDEAS COMPOSITES PROGRAM WILL TRAIN A TOTAL OF 50 STUDENTS; OF THESE, 25 WILL BE NRT-FUNDED IDEAS FELLOWS AND THE REMAINING 25 WOULD BE IDENTIFIED AS IDEAS SCHOLARS. THE PROGRAM WILL DRAW TRAINEES FROM COMPUTER SCIENCE, DATA SCIENCE, STATISTICAL SCIENCE, MECHANICAL ENGINEERING, AUTOMOTIVE ENGINEERING, AND MATERIALS SCIENCE AND WILL EMPOWER TRAINEES WITH AN ACADEMIA?INDUSTRY CO-TRAINED SKILL SET THAT WILL ENSURE THEIR SUCCESS IN THE AI AGE. THE RESEARCH THEME OF THIS NRT PROGRAM IS FOCUSED ON DISCOVERING AND INVESTIGATING THE EFFECTIVENESS OF A PHYSICS-INFORMED, MACHINE-LEARNING-BASED INVERSE DESIGN PLATFORM FOR DEVELOPING NEW COMPOSITE MATERIAL ARCHITECTURES AND MANUFACTURING METHODOLOGIES. THE PROGRAM WILL TRAIN A COHORT OF GRADUATE STUDENTS WITH DEEP, SPECIALIZED EXPERTISE SUPPORTED BY BROAD, CROSS-SKILL KNOWLEDGE, AND EQUIP THEM WITH A UNIQUE ?DNA-SHAPED? SKILL SET COLLABORATIVELY FACILITATED BY BOTH ACADEMIC AND INDUSTRY EXPERTS. SPECIFICALLY, THE PROGRAM WILL (1) CATALYZE INTERDISCIPLINARY RESEARCH AT THE INTERSECTION OF AI AND THE INVERSE DESIGN OF COMPOSITES AND MANUFACTURING INNOVATION VIA CONSTRUCTING A ?DIGITAL LIFE CYCLE? WHICH IS A SUITE OF HIGH-FIDELITY MODELS FOR SIMULATING A COMPOSITE COMPONENT?S LIFE CYCLE, INVESTIGATING THE APPLICATION OF MACHINE-LEARNING METHODS FOR INVERSE COMPOSITE MATERIAL ARCHITECTURE AND MANUFACTURING PROCESS DESIGN, AND DEVELOPING AN INVERSE DESIGN APPROACH FOR INTEGRATED MATERIAL AND MANUFACTURING DESIGN; (2) EXPLORE A COMBINED GRADUATE AND UNDERGRADUATE STUDENT TRAINING MODEL COMPRISING A COMPOSITES INVERSE DESIGN CAPSTONE AND A RESEARCH DESIGN, DEVELOPMENT, AND DEMONSTRATION (RD&D) PROJECT CENTERING ON RESEARCH OUTCOMES APPLIED TO INDUSTRY PROBLEMS; (3) CREATE A DIVERSE, EQUITABLE, AND INCLUSIVE ENVIRONMENT FOSTERING INTERDISCIPLINARY COLLABORATION IN WHICH TRAINEES ARE PREPARED FOR CAREERS REQUIRING A UNIQUE ?DNA-SHAPED? SKILL SET; AND (4) ESTABLISH AN INTERDISCIPLINARY EDUCATION PROGRAM TO (A) PREPARE NEXT-GENERATION COMPOSITES ENGINEERING GRADUATES (ALTOGETHER 50 BY YEAR 5) WHO WILL HAVE AI-ENABLED INVERSE DESIGN EXPERTISE AND SKILLS NECESSARY TO MEET THE UNIQUE CHALLENGES OF THE COMING AI AGE AND TO THRIVE IN THE COMPOSITES INDUSTRY, AND (B) TRAIN THE CURRENT WORKFORCE TO ENHANCE THEIR KNOWLEDGE AND FOSTER DISSEMINATION OF AI METHODS AND PRINCIPLES IN THE COMPOSITES ENGINEERING COMMUNITY. THE NSF RESEARCH TRAINEESHIP (NRT) PROGRAM IS DESIGNED TO ENCOURAGE THE DEVELOPMENT AND IMPLEMENTATION OF BOLD, NEW POTENTIALLY TRANSFORMATIVE MODELS FOR STEM GRADUATE EDUCATION TRAINING. THE PROGRAM IS DEDICATED TO EFFECTIVE TRAINING OF STEM GRADUATE STUDENTS IN HIGH PRIORITY INTERDISCIPLINARY OR CONVERGENT RESEARCH AREAS THROUGH COMPREHENSIVE TRAINEESHIP MODELS THAT ARE INNOVATIVE, EVIDENCE-BASED, AND ALIGNED WITH CHANGING WORKFORCE AND RESEARCH NEEDS.?? THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

NRT: TECHNOLOGY-HUMAN INTEGRATED KNOWLEDGE EDUCATION AND RESEARCH (THINKER)

NRT-DESE: PREPARING RESILIENT AND OPERATIONALLY ADAPTIVE COMMUNITIES THROUGH AN INTERDISCIPLINARY, VENTURE-BASED EDUCATION (PROACTIVE)

A UNIFIED MATERIALS APPROACH TO MITIGATING NONLINEARITIES IN HEL OPTICAL FIBERS

CC*DATA: NATIONAL CYBERINFRASTRUCTURE FOR SCIENTIFIC DATA ANALYSIS AT SCALE (SCIDAS)

PURPOSE: RECONSTRUCT TERMINAL; RECONSTRUCT PARKING LOT. ACTIVITIES TO BE PERFORMED/EXPECTED OUTCOMES: THIS PROJECT RECONSTRUCTS 4,768 SQUARE FEET OF EXISTING GENERAL AVIATION TERMINAL. THIS GRANT FUNDS REPLACEMENT OF ENTIRE BUILDING THAT HAS REACHED THE END OF ITS USEFUL LIFE. THIS PROJECT RECONSTRUCTS THE EXISTING 34,174 SQUARE FOOT NONREVENUE GENERATING PARKING LOT AT A NON HUB AIRPORT THAT HAS REACHED THE END OF ITS USEFUL LIFE. INTENDED BENEFICIARY: THIS GRANT WILL PROVIDE FEDERAL FUNDING FOR AIRPORTS ASSOCIATED WITH MARION, ILLINOIS.

TREE AND WOOD PEST INITIATIVE - ASIAN LONGHORNED BEETLE ERADCATION FOR SOUTH CAROLINA

WASTE DISPOSAL GRANTS - REGULAR

PSYCHOSOCIAL AND NEIGHBORHOOD MECHANISMS AND CONSEQUENCES OF BLACK-WHITE SLEEP DISPARITIES ON COGNITION - PROJECT SUMMARY BLACK-WHITE DIFFERENCES HAVE BEEN OBSERVED IN COGNITIVE PERFORMANCE AND RISK FOR COGNITIVE IMPAIRMENT, PARTICULARLY ALZHEIMER’S DISEASE AND RELATED DEMENTIAS (ADRD). FEW STUDIES HAVE EXAMINED HOW SLEEP MAY FURTHER EXPLAIN THESE DISPARITIES, ESPECIALLY CONSIDERING THAT SLEEP DISTURBANCES ARE COMMON IN BLACKS. SINCE DISPARITIES IN COGNITION AND SLEEP HAVE BEEN OBSERVED IN MIDDLE-AGED ADULTS, THIS PORTION OF THE LIFESPAN IS IDEAL TO INVESTIGATE THE ASSOCIATION BETWEEN SLEEP AND COGNITIVE DECLINE AS WELL AS THE UNDERLYING PSYCHOSOCIAL, CONTEXTUAL, AND BIOMARKER FACTORS THAT INFLUENCE SLEEP AND/OR COGNITIVE BLACK-WHITE DISPARITIES. EVERY YEAR FOR 4 YEARS, THE PROPOSED STUDY WILL COLLECT MEASURES OF SLEEP DURATION AND QUALITY, COGNITIVE FUNCTIONING, INFLAMMATORY BIOMARKERS (E.G., CRP, IL-6), LIFE STRESSORS, AND RESILIENCE FACTORS (E.G., SPIRITUALITY, COPING) IN A SAMPLE OF MIDDLE- AGED BLACK AND WHITE PARTICIPANTS FROM THE HEALTHY AGING IN NEIGHBORHOODS OF DIVERSITY ACROSS THE LIFE SPAN (HANDLS) STUDY. THE OVERALL OBJECTIVE OF THIS STUDY IS TO IDENTIFY MECHANISMS OF BLACK-WHITE SLEEP DISPARITIES AND THE MECHANISMS THAT ACCOUNT FOR BLACK- WHITE DIFFERENCES IN ADRD RISK. THE CENTRAL HYPOTHESIS IS THAT RACIAL DISPARITIES IN SLEEP WILL BE ASSOCIATED WITH RACIAL DISPARITIES IN COGNITIVE DECLINE. GUIDED BY THE INVESTIGATORS’ PREVIOUS RESEARCH, THREE SPECIFIC AIMS WILL BE TESTED: 1) TO DETERMINE IF THERE ARE RACIAL DIFFERENCES IN THE DAILY COUPLING OF SLEEP AND MOBILE COGNITIVE PERFORMANCE AND WHETHER DIFFERENCES IN THIS COUPLING ARE MODERATED BY LIFE STRESSORS (E.G., FINANCIAL STRAIN AND NEIGHBORHOOD DISORDER); 2) TO TEST LONGITUDINAL ASSOCIATIONS AMONG SLEEP AND PERFORMANCE ON MOBILE COGNITIVE ASSESSMENTS AND EXPLORE THE ROLE OF LIFE STRESSORS, PROTECTIVE FACTORS (E.G., SPIRITUALITY AND NEIGHBORHOOD COHESION) AND INFLAMMATION; 3) TO DETERMINE WHETHER CHANGES IN THE STRENGTH OF THE DAILY COUPLING OF SLEEP AND PERFORMANCE ON MOBILE COGNITIVE ASSESSMENTS RELATE TO RACIAL DIFFERENCES IN TRADITIONAL CLINICAL MEASURES OF COGNITIVE DECLINE OVER 4 YEARS, AND TO ELUCIDATE THE POTENTIAL MEDIATIONAL ROLE OF INFLAMMATION. THIS APPROACH IS INNOVATIVE BECAUSE IT WILL NOT ONLY EXAMINE THE ASSOCIATION BETWEEN SLEEP AND COGNITIVE FUNCTIONING OVER TIME, BUT WILL ALSO EXAMINE THE RELATIONSHIP OF LIFE STRESSORS, SLEEP, INFLAMMATORY BIOMARKERS, AND/OR RESILIENT FACTORS ON RACIAL DISPARITIES IN COGNITIVE DECLINE. THE PROPOSED RESEARCH IS SIGNIFICANT BECAUSE OF ITS POTENTIAL TO IDENTIFY PSYCHOSOCIAL AND CONTEXTUAL FACTORS RELATED TO IMPAIRED SLEEP AND COGNITION THAT COULD SERVE AS THE BASIS FOR EVIDENCE-BASED BEHAVIORAL OR POLICY INTERVENTIONS.

HYDROGEN HAS BEEN IDENTIFIED AS A KEY COMPONENT OF A COMPREHENSIVE PORTFOLIO OF ENERGY TECHNOLOGIES TO SUPPORT THE TRANSITION TO A NET-ZERO EMISSION ECONOMY. ENERGY TRANSITION FROM FOSSIL FUELS TO RENEWABLE SOURCES WILL REQUIRE SIGNIFICANT TECHNOLOGICAL ADVANCEMENTS IN ALL AREAS INCLUDING GREEN HYDROGEN PRODUCTION, STORAGE, TRANSPORT, DELIVERY, SAFETY, AND UTILIZATION. AS AN R1 INSTITUTION AND TOP-RANKED LAND GRANT PUBLIC UNIVERSITY IN THE STATE OF SOUTH CAROLINA AND THE NATION, CLEMSON UNIVERSITY HAS BEEN WELL RECOGNIZED FOR ITS STRENGTHS IN FUNDAMENTAL AND APPLIED RESEARCH IN MANY AREAS SUCH AS ADVANCED MANUFACTURING, ADVANCED MATERIALS, SENSORS AND CONTROLS, ENERGY MODELING, ELECTRIC POWER, AND GRID MODERNIZATION. CLEMSON UNIVERSITY ALSO HAS EXISTING FACULTY MEMBERS WHOSE RESEARCH INTERESTS HAVE INCLUDED HYDROGEN AND DECARBONIZATION. THIS PROJECT WILL FURTHER CLEMSON UNIVERSITY’S LEADERSHIP ROLE IN GREEN HYDROGEN AND DECARBONIZATION RESEARCH, EDUCATION, WORKFORCE DEVELOPMENT, COMMUNITY ENGAGEMENT, AND ECONOMIC ENHANCEMENT. SUCCESSFUL COMPLETION OF THE PROJECT WILL ALLOW CLEMSON UNIVERSITY TO 1) ENHANCE ITS RESEARCH CAPACITY BY ESTABLISHING CUTTING-EDGE CAPABILITIES DEDICATED TO HYDROGEN AND DECARBONIZATION RESEARCH, AND 2) LEVERAGE THE EXISTING STRENGTHS AT CLEMSON UNIVERSITY AND CONDUCTING SYNERGISTIC RESEARCH AND EDUCATION/WORKFORCE DEVELOPMENT IN NEXT GENERATION HYDROGEN TECHNOLOGIES. THE PROJECT WILL ADVANCE THE TECHNOLOGIES ASSOCIATED WITH THE PRODUCTION, STORAGE, TRANSPORT, DELIVERY, AND UTILIZATION OF HYDROGEN, ASSISTING DECARBONIZATION GOALS OF REGIONAL STAKEHOLDERS, PROMOTING ECONOMIC DEVELOPMENT IN THE STATE OF SOUTH CAROLINA, THE SOUTHEAST REGION AND THE ENTIRE NATION.

ATTRACT: ASSESSMENT OF TEMPOROMANDIBULAR JOINT MORPHOLOGY, MECHANICS, AND MECHANOBIOLOGY IN CLASS II AND III TARGET AND SURGICAL PHENOTYPES - PROJECT SUMMARY CRANIOFACIAL SKELETAL DEFORMITIES INCLUDE MANDIBULAR RETROGNATHISM (MR), WHICH IS CLASS II SKELETAL DEFORMITY OCCURRING IN ~5% OF INDIVIDUALS, AND MANDIBULAR PROGNATHISM (MP), WHICH IS CLASS III SKELETAL DEFORMITY OCCURRING IN ~1% OF INDIVIDUALS. THERE IS AN ASSOCIATION BETWEEN CRANIOFACIAL SKELETAL DEFORMITY AND TMJ DISORDERS, WITH DEGENERATIVE CHANGES IN 43% OF CLASS II AND 20% OF CLASS III DEFORMITIES, BUT ONLY IN 3% OF CLASS I (I.E., NO SKELETAL DEFORMITY). MOREOVER, CLASS II FEMALES WHICH TYPICALLY HAVE SMALLER CONDYLES, HAVE A MUCH HIGHER RISK TO DEVELOP TMJ DYSFUNCTION. EVEN THOUGH THERE IS INCREASING EVIDENCE THAT CRANIOFACIAL SKELETAL DEFORMITY MAY BE AN IMPORTANT RISK FACTOR FOR THE DEVELOPMENT OF TMJ DISORDERS, ONLY STUDYING MORPHOLOGICAL PARAMETERS HAS NOT GIVEN ANY INSIGHT INTO A BIOLOGICAL MECHANISM OR A CAUSE-EFFECT RELATIONSHIP. ADDITIONALLY, ORTHOGNATHIC SURGERY CAN BE BENEFICIAL BY ADJUSTING SKELETAL MORPHOLOGY, BUT ITS EFFICACY ON TMJ FUNCTION IS POORLY UNDERSTOOD. JOINT MORPHOLOGY DRIVES BIOMECHANICS, WHICH IN TURN REGULATES MECHANOBIOLOGY IN JOINT TISSUE REMODELING. IDENTIFYING THE MECHANISTIC RELATIONSHIPS BETWEEN CRANIOFACIAL MORPHOLOGY, TMJ BIOMECHANICS, AND JOINT MECHANOBIOLOGY, HAS LED TO A BETTER UNDERSTANDING OF THE ETIOLOGY AND SEX DISPARITY OF TMJ DISORDERS. SPECIFICALLY, SMALLER CONDYLES AND SHORTER MANDIBLES INCREASE FEMALE TMJ LOADS, CONTACT STRESSES AND ENERGY DENSITY, WHILE DECREASING BOTH TISSUE NUTRIENT AVAILABILITY AND CELL VIABILITY, LEADING TO PATHOLOGICAL TMJ REMODELING. THE OBJECTIVE OF THIS APPLICATION IS TO TAKE THIS SAME INTEGRATED APPROACH OF TMJ MORPHOLOGY, MECHANICS, AND MECHANOBIOLOGY BUT IN THE CONTEXT OF CLASS II AND III PHENOTYPES. OUR OVER-ARCHING HYPOTHESIS IS THAT MECHANICAL LOADING MAGNITUDE, AS WELL AS TISSUE NUTRIENT AVAILABILITY AND CELL VIABILITY, OF THE TMJ ARE SIGNIFICANTLY DIFFERENT BETWEEN SKELETALLY MATURE INDIVIDUALS WITH CLASS I, II, AND III PHENOTYPES. MORE SPECIFICALLY WE HYPOTHESIZE THAT THE TMJ IN CLASS II FEMALES HAS THE HIGHEST MECHANICAL LOADING, LOWEST TISSUE NUTRIENT AVAILABILITY, AND LOWEST CELL VIABILITY DUE TO DISPROPORTIONALLY SMALL CONDYLE AND SHORT MANDIBLE, AND THAT ORTHOGNATHIC SURGERY CAN IMPROVE BOTH TMJ BIOMECHANICS AND MECHANOBIOLOGY, THUS GIVING MECHANISTIC INSIGHT. WE PROPOSE THREE SPECIFIC AIMS (1) DETERMINE DIFFERENCES IN CRANIOFACIAL MORPHOLOGY AND TMJ BIOMECHANICS BETWEEN INDIVIDUALS WITH CLASS I, II, AND III PHENOTYPES. (2) DETERMINE DIFFERENCES IN TMJ MECHANOBIOLOGICAL INDICATORS BETWEEN INDIVIDUALS WITH CLASS I, II, AND III PHENOTYPES. (3) DETERMINE DIFFERENCES IN TMJ MORPHOLOGY, MECHANICS, MECHANOBIOLOGY BEFORE AND AFTER ORTHOGNATHIC SURGERY IN INDIVIDUALS WITH CLASS II AND III PHENOTYPES. THIS PROJECT COMBINES EXPERTISE IN MORPHOLOGIC CHARACTERIZATION AND TREATMENT OF CRANIOFACIAL DEFORMITIES OF NIDCR CLINICAL CENTER INTRAMURAL INVESTIGATORS, WITH THE TMJ BIOMECHANICS AND MECHANOBIOLOGY MEASUREMENT AND MODELING EXPERTISE OF THE EXTRAMURAL APPLICANTS. THE OUTCOMES WILL (I) IDENTIFY CLINICALLY MEASURABLE RISK FACTORS FOR TMJ DISORDERS IN SKELETAL DEFORMITY PATIENTS, (II) JUSTIFY THE BENEFIT OF ORTHOGNATHIC SURGERY FOR RESTORING TMJ HEALTH, AND (III) GUIDE FUTURE PATIENT-SPECIFIC SURGICAL PLANNING TO OPTIMIZE POST-OP TMJ FUNCTION.

SMITH LEVER 3B&C FUNDS

SMITH LEVER 3B&C FUNDS

NEW AWARD TO CLEMSON UNIVERSITY. AWARD NUMBER: DE-FE0031765. PROJECT ENTITLED: TEST AND VALIDATE DISTRIBUTED COAXIAL CABLE SENSORS FOR IN SITU CONDITION MONITORING OF COAL-FIRED BOILER TUBES.

THE OBJECTIVE IS TO DEVELOP A CROSS-CUTTING SUITE OF SOUTH ASIA-RELATED RESEARCH AND OUTREACH ACTIVITIES DESIGNED TO FURTHER THREE KEY DEPARTMENT OF ENERGY/NATIONAL NUCLEAR SECURITY ADMINISTRATION (DOE/NNSA) AND USG GOALS: 1) CAPACITY-BUILDING EFFORTS WITH REGIONAL POLICYMAKERS AND RISING ANALYSTS ON NUCLEAR RISK AND ARMS CONTROL CHALLENGES, 2) ENGAGEMENT OF CIVILIAN AND MILITARY CONSTITUENCIES ON NONPROLIFERATION AND STRATEGIC STABILITY, AND 3) GENERATION OF INSIGHTS TO INFORM DOMESTIC AND INTERNATIONAL PUBLIC POLICY AND GUIDE NUCLEAR NONPROLIFERATION POLICY FORMULATION NONPROLIFERATION POLICY FORMULATION.

ADVANCED NURSING EDUCATION WORKFORCE

THE HATCH ACT OF 1887 (REGULAR RESEARCH) - CLEMSON UNIVERSITY

PUBLIC HOUSING CAPITAL FUND

GRANT FOR PROD OF ADV BIOFUEL

THE HATCH ACT OF 1887 (REGULAR RESEARCH) - CLEMSON UNIVERSITY

REDUCING DISPARITIES IN BIRTH OUTCOMES: A RANDOMIZED CONTROLLED TRIAL ON CENTERINGPREGNANCY

ECONOMIC DEVELOPMENT INITIATIVE, COMMUNITY PROJECT FUNDING, AND MISCELLANEOUS GRANTS

WILLIAMSON HEALTH AND WELLNESS CENTER'S APPLICATION TO EXPAND ITS MAT PROGRAM IN MINGO COUNTY, WV. - WILLIAMSON HEALTH AND WELLNESS CENTER (WHWC), A FEDERALLY QUALIFIED HEALTH CENTER, IS THE PRIMARY SAFETY-NET HEALTHCARE PROVIDER SERVING MINGO COUNTY, WEST VIRGINIA. MINGO COUNTY (POP. 24,471; AREA 423 SQ. MILES) IS LOCATED IN SOUTHWEST WV ALONG THE KENTUCKY BORDER AND THE POPULATION IS PRIMARILY RURAL (90%) WITH MOST RESIDENTS TRAVELING TO THE CITY OF WILLIAMSON (POP. 2,883) FOR DAILY NEEDS. WHWC IS PROPOSING TO SIGNIFICANTLY EXPAND ITS ABILITY TO SUPPORT OUD PREVENTION, TREATMENT, AND SUSTAINED RECOVERY FOR INDIVIDUALS SUFFERING FROM ILLICIT OPIOID DRUG USE/ PRESCRIPTION OPIOID MISUSE THROUGHOUT SOUTHERN WEST VIRGINIA BY BUILDING UPON A RECENTLY ESTABLISHED MAT PROGRAM THAT INCLUDES THE USE OF FDA-APPROVED MEDICATIONS, COUNSELING, SCREENING AND ASSESSMENT, CASE MANAGEMENT, RECOVERY SUPPORT SERVICES, AND TELEHEALTH SERVICES WITHIN A FULLY INTEGRATED PRIMARY CARE / BEHAVIORAL HEALTH MODEL. WHWC IS PROPOSING TO EXPAND CRITICAL ACCESS TO MAT SERVICES TO MEET THE DEMAND AMONG THE TARGET POPULATION TO REDUCE ILLICIT OPIOID DRUG USE/PRESCRIPTION OPIOID MISUSE, AS WELL AS SUPPORT THE FULL RECOVERY AND IMPROVED HEALTH OUTCOMES OF CLIENTS USING THE FOLLOWING EVIDENCE-BASED SERVICES: 1) MEDICATION-ASSISTED TREATMENT (MAT); 2) MOTIVATIONAL INTERVIEWING/ENHANCEMENT; 3) COGNITIVE BEHAVIORAL THERAPY (CBT); 4) TRAUMA-INFORMED CARE (TIC); 5) ASSERTIVE COMMUNITY TREATMENT WITH MODIFICATION (ACT); 6) PEER SUPPORT SPECIALISTS AND 7) EYE MOVEMENT DESENSITIZATION AND REPROCESSING (EMDR).

NOVEL FIBER CONCEPTS FOR HIGH POWER SINGLE MODE FIBER LASERS

QUIC-TAQS: VOLTAGE-TUNABLE HYBRID MICROWAVE-ACOUSTIC INTERCONNECTS FOR MULTI-MODAL QUANTUM MEMORIES

DEVELOPING A DYNAMIC MODELING FRAMEWORK FOR SURVEILLANCE, PREDICTION, AND REAL-TIME RESOURCE ALLOCATION TO REDUCE HEALTH DISPARITIES DURING COVID-19 AND FUTURE PANDEMICS - PROJECT SUMMARY BLACK, HISPANIC, AND RURAL AMERICANS ARE TWICE AS LIKELY TO DIE FROM CORONAVIRUS DISEASE 2019 (COVID-19). THESE HEALTH DISPARITIES HAVE BEEN FUELED BY INADEQUATE ACCESS TO ESSENTIAL RESOURCES THROUGHOUT THE PANDEMIC. SUCH INEQUITIES ARE NOT UNIQUE TO COVID-19. OVER THE PAST CENTURY, EMERGING INFECTIOUS DISEASES HAVE SIGNIFICANTLY PERPETUATED HEALTH DISPARITIES IN UNDERSERVED COMMUNITIES. THE INTERCONNECTED PATHWAYS LEADING TO THESE DISPARITIES, INCLUDING HETEROGENEOUS DISEASE EPIDEMIOLOGY, SOCIODEMOGRAPHIC CHARACTERISTICS, AND TREATMENT ACCESS AND UPTAKE, REMAIN UNDERSTUDIED. MOBILE HEALTH CLINICS (MHC) ARE AN EFFECTIVE AND VERSATILE TOOL FOR REDUCING HEALTH DISPARITIES THROUGH TIMELY DELIVERY OF INTERVENTIONS TO MEDICALLY UNDERSERVED POPULATIONS. HOWEVER, THE INABILITY TO EFFECTIVELY IDENTIFY AND PRIORITIZE HIGH-RISK COMMUNITIES HAS POSED DAUNTING CHALLENGES FOR MHC DECISION MAKERS AND HAS LED TO SUBOPTIMAL ALLOCATION STRATEGIES. TO HELP IMPROVE THE EFFICIENCY OF THESE FIELD-LEVEL INTERVENTIONS AND REDUCE HEALTH DISPARITIES DURING COVID-19 AND FUTURE PANDEMICS, OUR PROPOSAL SEEKS TO DEVELOP A MODELING TOOLKIT TO IMPROVE INFECTIOUS DISEASE SURVEILLANCE AND PREDICTION IN UNDERSERVED POPULATIONS AND PRIORITIZE THE DELIVERY OF ESSENTIAL RESOURCES TO HIGH-RISK COMMUNITIES IN REAL TIME. OUR INNOVATIVE, MULTILEVEL MODELING FRAMEWORK WILL UTILIZE STATISTICAL MODELS, MACHINE LEARNING, COMPARTMENT-BASED AND AGENT-BASED MODELS TO REDUCE HEALTH DISPARITIES THROUGH 1) ESTABLISHING A REAL-TIME DATA SYSTEM FEED FOR INFECTIOUS DISEASE SURVEILLANCE AND ESTIMATION OF DISEASE EPIDEMIOLOGY IN UNDERSERVED COMMUNITIES 2) IDENTIFYING AT-RISK POPULATIONS FOR ALLOCATION OF ESSENTIAL RESOURCES, 3) EVALUATING THE COMPLEX INTERPLAY BETWEEN SOCIODEMOGRAPHIC AND CLINICAL CHARACTERISTICS, INFECTIOUS DISEASE EPIDEMIOLOGY, MODIFIABLE HEALTH BARRIERS, AND INTERVENTION UPTAKE IN ORDER TO IMPROVE EMERGENCY PLANNING DURING THE COVID-19 PANDEMIC AND FUTURE HEALTH EMERGENCIES, AND 4) ESTABLISHING A MODELING TOOLKIT TO INFORM DELIVERY OF ESSENTIAL RESOURCES TO UNDERSERVED COMMUNITIES IN REAL-TIME. THIS WILL BE ACCOMPLISHED THROUGH REAL-TIME INTEGRATION OF INFECTIOUS DISEASE OUTCOME DATA, DEMOGRAPHIC, SOCIOECONOMIC, AND CLINICAL CHARACTERISTICS, VACCINE HESITANCY SURVEYS, COMMUNITY-LEVEL CONTEXTUAL FACTORS, AND DATA ON STRUCTURAL BARRIERS TO HEALTH CARE FOR ESTIMATION OF KEY INPUT PARAMETERS IN THE DYNAMIC SIMULATION MODELING FRAMEWORK. THE FRAMEWORK WE PROPOSE WILL BE GENERALIZABLE TO OTHER INFECTIOUS DISEASES, WHERE MODEL INPUTS WILL BE DISEASE AND LOCATION DEPENDENT FOR SWIFT TRANSLATION TO OTHER PUBLIC HEALTH PROBLEMS. TO DEMONSTRATE THE UTILITY OF OUR TOOLKIT, OUR MODELING FRAMEWORK WILL FOCUS ON DELIVERY OF COVID-19 MOBILE VACCINATION CLINICS TO UNDERSERVED POPULATIONS IN SOUTH CAROLINA (SC). OUR PROPOSAL WILL IMPROVE PANDEMIC PLANNING BY DEVELOPING THE MODELING INFRASTRUCTURE FOR DISEASE SURVEILLANCE AND UNDERSTANDING OF INFECTIOUS DISEASE EPIDEMIOLOGY IN UNDERSERVED COMMUNITIES, ULTIMATELY IMPROVING TIMELY DELIVERY OF ESSENTIAL RESOURCES TO THOSE OF GREATEST NEED. COVID-19 HAS CLAIMED NEARLY 1 MILLION AMERICAN LIVES AND HAS HOSPITALIZED OVER 4 MILLION INDIVIDUALS THROUGH FEBRUARY 2022. UTILIZATION OF THIS TOOLKIT BY PUBLIC HEALTH DECISION MAKERS CAN PREVENT THOUSANDS OF FUTURE COVID-19 DEATHS. THROUGH ADAPTATION OF INPUT DATA SOURCES, OUR MODELING FRAMEWORK IS EASILY TRANSLATABLE TO OTHER INFECTIOUS DISEASES AND GEOGRAPHIC REGIONS AND HAS POTENTIAL TO SAVE MANY MORE LIVES IN FUTURE PANDEMICS.

MTM2: DRIVERS OF FUNCTIONAL REDUNDANCY ACROSS MICROBIOMES

DISCOVERING STRUCTURED PEPTIDE CATALYST BY REACTIVE TAGGING

GENETIC BASIS OF LIFESPAN AND HEALTHSPAN EXTENSION BY ACE INHIBITION IN DROSOPHILA - PROJECT SUMMARY STUDIES ACROSS A BROAD RANGE OF SPECIES HAVE ESTABLISHED A COMMON SET OF EVOLUTIONARILY CONSERVED HALLMARKS OF AGING, INCLUDING AGE-RELATED DECLINE IN MOBILITY AND MITOCHONDRIAL FAILURE. THIS EVIDENCE POINTS TO THE POTENTIAL FOR PHARMACOLOGICAL INTERVENTION TO IMPROVE HEALTHY AGING AND EXTEND LONGEVITY. PHARMACOLOGICAL BLOCKADE OF THE RENIN ANGIOTENSIN SYSTEM (RAS) BY INHIBITION OF THE ANGIOTENSIN-CONVERTING ENZYME (ACE) IS AN EFFECTIVE THERAPY IN IMPROVING AGE-RELATED IMPAIRMENT OF PHYSICAL FUNCTION AND IS A POTENTIAL STRATEGY TO SLOW HUMAN AGING. THE BENEFICIAL EFFECT OF ACE IHIBITION IN REDUCING AGE-ASSOCIATED DAMAGE OF TISSUES, SUCH AS THE SKELETAL MUSCLE, MAY BE ATTRIBUTED IN PART BY THE DRUG’S CAPACITY TO PRESERVE MITOCHONDRIAL FUNCTION. HOWEVER, IMPROVEMENT IN PHYSICAL PERFORMANCE IN RESPONSE TO RAS BLOCKADE VARIES WIDELY IN HUMAN STUDIES, POTENTIALLY DUE TO GENETIC VARIATION AMONG INDIVIDUALS. RESEARCH IN THIS AREA HAS BEEN SLOWED BY LACK OF UNDERSTANDING OF THE BIOLOGY THAT CONNECTS AGING, GENETICS, AND RESPONSE TO DRUG TREATMENT AND BECAUSE OF THE SHORTAGE OF APPROPRIATE ANIMAL MODELS FOR BIOLOGICAL AND INTERVENTION STUDIES. TO TACKLE THIS ISSUE, WE PROPOSE TO LEVERAGE THE EVOLUTIONARY CONSERVATION OF ACE ACROSS SPECIES TO DETERMINE THE GENETIC BASIS FOR THE ANTI-AGING EFFECT OF THE ACEI LISINOPRIL IN THE INVERTEBRATE MODEL D. MELANOGASTER. THE PROPOSED RESEARCH BUILDS ON A POWERFUL GENOMICS RESOURCE, THE DROSOPHILA GENETIC REFERENCE PANEL (DGRP), WHICH CONSISTS OF GENETICALLY DISTINCT LINES OF FLIES DERIVED FROM A NATURAL POPULATION. OUR PRELIMINARY STUDIES USING THREE GENETICALLY DIVERSE DGRP LINES REVEALED THAT TREATMENT WITH LISINOPRIL EXTENDS LIFESPAN AND IMPROVES AGE-SPECIFIC WALKING IN D. MELANOGASTER, BUT IT DOES SO IN A GENOTYPE-SPECIFIC MANNER. OUR DATA ALSO SUGGEST THAT GENOTYPE-SPECIFIC RESPONSES TO LISINOPRIL MAY ACT, IN PART, THROUGH VARIATION IN THE DEGREE TO WHICH MITOCHONDRIAL FUNCTION IS AFFECTED BY THE DRUG TREATMENT. TO ADDRESS THIS HYPOTHESIS, WE PROPOSE TO USE GENOME-WIDE ASSOCIATION MAPPING IN 400 NEW DGRP LINES TO FIRST IDENTIFY VARIANTS, GENES AND GENETIC PATHWAYS THAT RESPOND TO ACEI TO AMELIORATE AGE-RELATED DECLINE IN LOCOMOTOR ACTIVITY AND EXTEND LIFESPAN (AIM 1). FUNCTIONAL GENETIC STUDIES USING RNA INTERFERENCE (RNAI) OF CANDIDATE GENES ARE THEN PROPOSED TO VALIDATE THE EFFECTS OF ACEI ON LIFESPAN AND HEALTHSPAN AND TO TEST WHETHER THESE EFFECTS ARE MEDIATED VIA CHANGES IN MITOCHONDRIAL FUNCTION IN SKELETAL MUSCLE (AIM 2). FINALLY, WE PROPOSE TO EVALUATE THE GENOME WIDE EFFECTS OF ACEI ON GENE EXPRESSION AND THE METABOLOME FOR GENES FOR WHICH RNAI IN THORACIC MUSCLE EXTENDS LIFESPAN AND/OR HEALTHSPAN IN ORDER TO GAIN INSIGHT INTO THE MECHANISM(S) BY WHICH ACEI MODULATES LIFESPAN AND HEALTHSPAN (AIM 3). COMPLETION OF THE PROPOSED STUDIES WILL IDENTIFY GENETIC AND METABOLIC PATHWAYS THAT REGULATE THE ACEI-MEDIATED IMPROVEMENT IN PHYSICAL PERFORMANCE IN OLDER INDIVIDUALS.

PURPOSE: THE PUBLIC HOUSING CAPITAL FUND PROGRAM (CFP) WAS CREATED BY AN AMENDMENT TO THE 1937 ACT BY THE QUALITY HOUSING AND WORK RESPONSIBILITY ACT (QHWRA) IN 1998 (ADDING SECTION 9(D) TO THE 1937 ACT MERGING PREVIOUS MODERNIZATION AND DEVELOPMENT PROGRAMS). THE CFP PROVIDES FINANCIAL ASSISTANCE IN THE FORM OF GRANTS TO APPROXIMATELY 2,770 PUBLIC HOUSING AGENCIES (PHAS), SERVING NEARLY ONE MILLION UNITS, IN ALL 50 STATES AND TERRITORIES, TO CARRY OUT CAPITAL AND MANAGEMENT ACTIVITIES INCLUDING THOSE LISTED IN SECTION 9(D)(1) OF THE UNITED STATES HOUSING ACT OF 1937 (1937 ACT). THE MAIN PURPOSE OF THE CFP FORMULA GRANT IS TO FUND PUBLIC HOUSING MODERNIZATION, DEVELOPMENT, MANAGEMENT IMPROVEMENTS, AND THE OTHER ELIGIBLE ACTIVITIES DESCRIBED IN 24 CFR PART 905. ADDITIONAL INFORMATION ON THE PUBLIC HOUSING CAPITAL FUND IS LOCATED ON THE OFFICE OF CAPITAL IMPROVEMENTS WEBSITE: OFFICE OF CAPITAL IMPROVEMENTS | HUD.GOV / U.S. DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT (HUD) ADDITIONAL INFORMATION ON PUBLIC HOUSING FUNDING CAN BE FOUND BY ACCESSING THE WEBSITE BELOW AND REVIEWING THE PUBLIC HOUSING DASHBOARD LINKED UNDER THE “DATA DASHBOARD AND ANALYTICS”. PUBLIC HOUSING | HUD.GOV / U.S. DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT (HUD); ACTIVITIES TO BE PERFORMED: THE PHAS RECEIVE FEDERAL FUNDS FROM THE U.S. DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT (HUD) TO ADMINISTER THE PUBLIC HOUSING FUND. PUBLIC HOUSING CAPITAL FUNDS MAY ONLY BE USED FOR ACTIVITIES THAT ARE DESCRIBED AS ELIGIBLE ACTIVITIES IN 24 CFR 905.200 AND ARE EITHER SPECIFIED IN AN APPROVED 5-YEAR ACTION PLAN OR APPROVED BY HUD FOR EMERGENCY WORK OR WORK NEEDED BECAUSE OF A NON-PRESIDENTIALLY DECLARED NATURAL DISASTER. PUBLIC HOUSING DEVELOPMENT, MODERNIZATION, AND FINANCING ARE THE MAJOR ACTIVITIES TO BE PERFORMED. DEVELOPMENT IS ACTIVITIES AND RELATED COSTS THAT ADD TO (OR SIGNIFICANTLY RECONFIGURE) PUBLIC HOUSING UNITS IN A PHA’S INVENTORY, INCLUDING CONSTRUCTION AND ACQUISITION OF ADDITIONAL PUBLIC HOUSING UNITS, WITH OR WITHOUT REHABILITATION, AND ANY-AND-ALL UNDERTAKINGS NECESSARY FOR PLANNING, DESIGN, FINANCING, LAND ACQUISITION, DEMOLITION, CONSTRUCTION, OR EQUIPMENT OF PUBLIC HOUSING UNITS, AND RELATED BUILDINGS, FACILITIES, AND/OR APPURTENANCES (I.E., NON-DWELLING FACILITIES/SPACES). DEVELOPMENT ALSO INCLUDES ANY MIXED-FINANCE MODERNIZATION, ALL RELEVANT MODERNIZATION USES (OTHER THAN MANAGEMENT IMPROVEMENTS), FINANCING USES, AND DEVELOPMENT OF NON-DWELLING SPACE WHERE SUCH SPACE IS NEEDED TO ADMINISTER, AND IS OF DIRECT BENEFIT TO A PUBLIC HOUSING PROJECT (I.E. HOUSING DEVELOPED, ACQUIRED, OR ASSISTED BY A PHA UNDER THE 1937 ACT, AND THE IMPROVEMENT OF ANY SUCH HOUSING), INCLUDING THE RESIDENTS. FINANCING DEBT AND FINANCING COSTS (E.G., ORIGINATION FEES, INTEREST) INCURRED BY A PHA FOR DEVELOPMENT OR MODERNIZATION OF PUBLIC HOUSING PROJECTS, INCLUDING MIXED-FINANCE DEVELOPMENT, THE CAPITAL FUND FINANCING PROGRAM (CFFP), AND ANY OTHER USE AUTHORIZED UNDER SECTION 30 OF THE 1937 ACT. MODERNIZATION INCLUDES ALL ELIGIBLE ACTIVITIES EXCEPT FOR DEVELOPMENT AND FINANCING. PHYSICAL WORK IS A MAJOR ACTIVITY AND IS WORK THAT IS DONE ON THE PHYSICAL STRUCTURES, SITE, AND GROUNDS OF A PUBLIC HOUSING PROPERTY OR STRUCTURE. MAJOR PHYSICAL ACTIVITIES INCLUDE DEMOLITION, RECONFIGURATION, EMERGENCY ACTIVITIES, ENERGY EFFICIENCY, NON-ROUTINE MAINTENANCE, PLANNED CODE COMPLIANCE, AND VACANCY REDUCTION. THE MEASURABLE OUTCOME OF THIS GRANT IS THAT HUD WILL BE ABLE TO TRACK THE AMOUNT OF DOLLARS SPENT ON IMPROVEMENTS TO THE STRUCTURES, UNITS, COMMON AREAS, UTILITIES, AND OTHER ELIGIBLE ACTIVITIES. ; EXPECTED OUTCOMES: THE EXPECTED OUTCOMES FOR PUBLIC HOUSING CAPITAL FUNDS OF APPROXIMATELY $3.2 BILLION WILL BE PUT INTO THE DEVELOPMENT, MODERNIZATION, AND FINANCING OF NEARLY 1 MILLION PUBLIC HOUSING UNITS ACROSS ALL 50 STATES AND TERRITORIES. THE PUBLIC HOUSING UNITS ARE UPDATED TO BE DECENT, SAFE, SANITARY AND TO COMPLY WITH FEDERAL HOUSING STANDARDS. PHAS CAN ALSO USE A PORTION OF THE CAPITAL FUNDING FOR MANAGEMENT IMPROVEMENTS OR OPERATING ACTIVITIES INCLUDING SAFETY AND SECURITY COSTS.; INTENDED BENEFICIARIES: THE INTENDED BENEFICIARIES FOR PUBLIC HOUSING CAPITAL FUNDS ARE THE LOW-INCOME PUBLIC HOUSING RESIDENTS.; SUBRECIPIENT ACTIVITIES: THE RECIPIENT DOES NOT INTEND TO SUBAWARD FUNDS.

ADVANCED NURSE EDUCATION-SEXUAL NURSE ASSAULT EXAMINER PROGRAM

AWARD PURPOSE: THE PURPOSE OF THIS AGREEMENT IS TO CONDUCT SURVEY, REGULATORY, OUTREACH, AND TREE REMOVAL OPERATIONS IN SUPPORT OF THE ASIAN LONGHORNED BEETLE- ALB (ANOPLOPHORA GLABRIPENNIS) ERADICATION PROGRAM IN CHARLESTON AND DORCHESTER COUNTIES. ACTIVITIES TO BE PERFORMED: COMPREHENSIVE DELIMITATION AND DETECTION SURVEYS THROUGHOUT THE ALB REGULATED AREA, TO BE CONDUCTED PRIMARILY BY CONTRACTED SURVEY PERSONNEL ADMINISTERED BY CLEMON DEPARTMENT OF PLANT INDUSTRY. CONDUCT OUTREACH AND EDUCATION EFFORTS THROUGHOUT THE STATE TO GAIN SUPPORT FROM INDUSTRY GROUPS, THE GENERAL PUBLIC, AND OTHER AFFECTED STAKEHOLDERS. REGULATORY OPERATIONS TO INCLUDE ISSUANCE OF COMPLIANCE AGREEMENTS, COMPLIANCE TRAININGS AND MONITORING, STATE-WIDE SURVEYS, AND ENFORCEMENT OF THE REGULATIONS. ASSIST AND SUPPORT OPERATIONS TO REMOVE INFESTED AND HIGH-RISK HOST TREES AND DEREGULATE REGULATED MATERIAL. DELIVERABLES AND EXPECTED OUTCOMES: EXPECTED OUTCOMES ARE THE CONTAINMENT AND EVENTUAL ERADICATION OF ASIAN LONGHORNED BEETLE FROM SOUTH CAROLINA. ALL DATA PERTAINING TO ALB SURVEY AND TREE REMOVAL ACTIVITIES WILL BE COLLECTED IN APHIS-APPROVED GEOSPATIAL MOBILE DATA COLLECTION APPLICATIONS AND HOSTED IN THE APHIS GIS PORTAL. INTENDED BENEFICIARY(IES): SOUTH CAROLINA FORESTRY AND GREEN INDUSTRY STAKEHOLDERS, AND THE GENERAL PUBLIC.SUBRECIPIENT ACTIVITIES, IF KNOWN OR SPECIFIED AT THE TIME OF AWARD: NONE.

BIO-AI: RESEARCH-PGR: HARNESSING MULTI-OMICS AND AI/ML TO UNVEIL NUTRIENT RECYCLING MECHANISMS IN MAIZE SENESCENCE -IN PLANTS, LIKE CORN, LEAF AGING (ALSO KNOWN AS SENESCENCE) IS ACCOMPANIED BY REGULAR CELLULAR AND PHYSIOLOGICAL CHANGES. SOME OF THESE CHANGES ARE OUTWARDLY VISIBLE--LIKE DRYING, LOSS OF GREEN COLOR DUE TO REDUCED PHOTOSYNTHESIS, AND BROWNING UNDER DROUGHT. OTHER CHANGES ARE NOT OBVIOUS TO THE NAKED EYE BUT ARE VERY IMPORTANT FOR THE PLANT. ONE SUCH CHANGE INVOLVES RECYCLING OF NUTRIENTS FROM THE AGING LEAF TO DEVELOPING PARTS OF THE PLANT, SUCH AS KERNELS ON THE EAR. THE TIMING OF SENESCENCE IS CRUCIAL?TOO EARLY RESULTS IN LOW GRAIN YIELD. BY CONTRAST, PLANTS THAT DELAY SENESCENCE AND STAY GREEN LONGER INTO THE GROWING SEASON TEND TO YIELD MORE GRAIN. EXACTLY WHAT CONTROLS THE TIMING AND THE MANY STEPS IN SENESCENCE IS NOT CLEARLY KNOWN. THIS PROJECT WILL DEVELOP NEW WAYS TO MEASURE CORN TRAITS DURING AGING, DISCOVER CAUSATIVE GENES, AND APPLY COMPUTATIONAL METHODS LIKE ARTIFICIAL INTELLIGENCE TO UNDERSTAND HOW NUTRIENT RECYCLING IN PLANTS CAN IMPROVE AGRICULTURAL OUTCOMES. THE PROJECT WILL ALSO PROVIDE INTERDISCIPLINARY TRAINING FOR UNDERGRADUATE AND GRADUATE STUDENTS, POSTDOCTORAL RESEARCHERS, AND HIGH SCHOOL TEACHERS TO HELP INSPIRE AND PREPARE THE NEXT GENERATION OF SCIENTISTS, ULTIMATELY STRENGTHENING CAPACITY IN PLANT BIOLOGY, DATA SCIENCE, AND AGRICULTURAL BIOTECHNOLOGY. THIS PROJECT AIMS TO UNCOVER THE GENETIC, METABOLIC, AND REGULATORY MECHANISMS THAT GOVERN LEAF SENESCENCE AND NUTRIENT REMOBILIZATION IN MAIZE?PROCESSES THAT DIRECTLY IMPACT GRAIN QUALITY, NITROGEN USE EFFICIENCY, AND OVERALL CROP PRODUCTIVITY. DESPITE THEIR AGRONOMIC IMPORTANCE, THE MOLECULAR DRIVERS OF SENESCENCE REMAIN POORLY UNDERSTOOD IN CEREALS. TO ADDRESS THIS GAP, HIGH-RESOLUTION, TIME-SERIES DATASETS WILL BE GENERATED ACROSS A GENETICALLY DIVERSE MAIZE PANEL, CAPTURING PHYSIOLOGICAL TRAITS, METABOLITE PROFILES, TRANSCRIPTOMES, AND CHROMATIN ACCESSIBILITY. SINGLE-CELL ASSAYS WILL ADD SPATIAL RESOLUTION TO SENESCENCE-RELATED TRANSCRIPTIONAL AND CHROMATIN CHANGES. THESE DATASETS WILL BE INTEGRATED USING ARTIFICIAL INTELLIGENCE TOOLS, SUCH AS LARGE LANGUAGE MODELS, AND MACHINE LEARNING TO IDENTIFY CAUSAL GENES, REGULATORY ELEMENTS, AND METABOLITE-PHENOTYPE ASSOCIATIONS. TOP CANDIDATE GENES WILL BE FUNCTIONALLY VALIDATED USING GENE-EDITING TECHNOLOGIES TO CONFIRM THEIR ROLES IN REGULATING SENESCENCE AND NUTRIENT ALLOCATION. THE RESULTING INSIGHTS WILL INFORM BREEDING AND BIOTECHNOLOGICAL STRATEGIES TO ENHANCE NITROGEN USE EFFICIENCY, REDUCE FERTILIZER INPUTS, AND IMPROVE RESILIENCE TO ABIOTIC STRESS. THIS PROJECT IS CO-FUNDED BY THE DIVISION OF INTEGRATIVE ORGANISMAL SYSTEMS PLANT GENOME RESEARCH PROGRAM AND BY THE DIVISION OF EMERGING FRONTIERS, BOTH IN THE DIRECTORATE FOR BIOLOGICAL SCIENCES. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE PLANNED FOR THIS AWARD.

VALIDATING SENSOR-BASED APPROACHES FOR MONITORING EATING BEHAVIOR AND ENERGY INTAKE BY ACCOUNTING FOR REAL-WORLD FACTORS THAT IMPACT ACCURACY AND ACCEPTABILITY - PROJECT SUMMARY/ABSTRACT ENERGY INTAKE (EI) PLAYS A CRITICAL ROLE IN THE ETIOLOGY AND PREVENTION OF PREVALENT AND DEBILITATING CHRONIC DISEASES SUCH AS OVERWEIGHT/OBESITY AND TYPE 2 DIABETES. SELF-MONITORING IS THE CORNERSTONE OF THE SELF- REGULATION APPROACH FOR REDUCING EI, BUT PREVAILING METHODS ARE BURDENSOME AND INACCURATE WHICH LIMITS OUR ABILITY TO UNDERSTAND EATING PATTERNS AND INTERVENE ON THEM TO IMPROVE HEALTH. THERE IS A CLEAR NEED FOR INNOVATIVE SOLUTIONS THAT CAN UNOBTRUSIVELY MONITOR AND RELIABLY ESTIMATE EI IN THE CONTEXT OF DAILY LIFE. FOR 10+ YEARS, OUR GROUP HAS RESEARCHED THE UTILITY OF A WRIST-WATCH DEVICE (E.G., SMARTWATCH) TO PASSIVELY MONITOR EATING BEHAVIOR BY MEASURING THE ACCELERATION AND ROTATION OF DOMINANT-HAND WRIST MOTION OF FOOD BEING BROUGHT TO THE MOUTH. THROUGH SEVERAL STUDIES WE HAVE REFINED OUR APPROACH FOR USING PATTERNS OF WRIST MOTION TO IDENTIFY INDIVIDUAL INTAKE GESTURES ("BITE" OF FOOD, "DRINK" OF BEVERAGE) DURING MEALS/SNACKS. WE HAVE SHOWN THAT WE CAN USE INTAKE GESTURE COUNT TO ESTIMATE MEAL-LEVEL EI BY USING ADVANCED MODELING TO ESTIMATE KILOCALORIES PER BITE (KPB) AND KILOCALORIES PER DRINK (KPD) (E.G., EI = #BITES X KPB + #DRINKS X KPD). WE ARE ON THE CUSP OF MAKING THIS APPROACH WIDELY AVAILABLE FOR CLINICAL APPLICATION, BUT OUR LATEST ADVANCES IN SENSOR- BASED EI ESTIMATION REQUIRE VALIDATION BEFORE THE METHOD IS TRULY VIABLE IN REAL-WORLD SETTINGS. IN THIS PROJECT WE WILL DEFINITIVELY ADDRESS 3 FINAL BARRIERS: 1) OUR APPROACH MUST BE VALIDATED ACROSS SETTINGS AND AMONG A HIGHLY REPRESENTATIVE SAMPLE; 2) OUR MODELS THAT USE INTAKE GESTURES TO ESTIMATE EI MUST ACCOUNT FOR VARYING CONTEXTS, SUCH AS DIFFERENT TYPES OF FOODS OR FOOD SOURCES, THAT COULD INFLUENCE EI; AND 3) WE MUST MAXIMIZE ACCEPTABILITY OF THE MEASUREMENT METHODS. THE PROPOSED STUDY WILL VALIDATE OUR SENSOR-BASED EI ESTIMATION METHODS AMONG A DIVERSE SAMPLE, ACROSS THREE SETTINGS (CAFETERIA, HOME-BASED, AND FREE-LIVING), INCORPORATING MINIMAL USER INPUT ON FOODS AND BEVERAGES (E.G., HIGH ENERGY DENSITY FOODS, ZERO CALORIE BEVERAGES) AND CONTEXTS (E.G., FOOD SOURCE, TIME OF DAY), AND USING TWO DIFFERENT SENSORS (COMMERCIAL SMARTWATCH AND SMART RING). WE WILL CONDUCT TWO CONTROLLED DATA COLLECTIONS IN WHICH A SINGLE MEAL IS VIDEO RECORDED WHILE PARTICIPANTS WEAR THE SMARTWATCH AND SMART RING: N=300 IN A CAFETERIA AND N=240 IN PARTICIPANT HOMES. ALL PARTICIPANTS (N=540) WILL THEN WEAR BOTH DEVICES AND COMPLETE REMOTE FOOD PHOTOGRAPHY DURING 4 DAYS OF EVERYDAY LIFE (FREE LIVING). WE WILL EVALUATE SENSOR-BASED ESTIMATES OF EI AGAINST GROUND TRUTH CAPTURED USING VIDEO (CAFETERIA AND HOME) AND REMOTE FOOD PHOTOGRAPHY METHOD (FREE-LIVING). WE WILL USE OUR FINDINGS TO CREATE A PRACTICAL PLATFORM TO GUIDE RESEARCHERS/CLINICIANS IMPLEMENTING A SENSOR-BASED EI SELF-MONITORING PROTOCOL THAT MAXIMIZES ACCURACY AND ACCEPTABILITY (SELECTING WRIST VS. RING SENSOR, TYPE OF USER INPUT, AND LENGTH OF SELF- MONITORING). OUR PLATFORM WILL ULTIMATELY SUPPORT WORK IN PRECISION NUTRITION BY TRANSFORMING HOW WE DEVELOP AND EVALUATE HEALTH-RELATED INTERVENTIONS, AND ULTIMATELY IMPROVE THE QUALITY OF INTERVENTIONS TARGETING EI.

CENTER FOR AVIATION AND AUTOMOTIVE TECHNOLOGY EDUCATION USING VIRTUAL E-SCHOOL [CA2VES]:

PURPOSE: THE PUBLIC HOUSING CAPITAL FUND PROGRAM (CFP) WAS CREATED BY AN AMENDMENT TO THE 1937 ACT BY THE QUALITY HOUSING AND WORK RESPONSIBILITY ACT (QHWRA) IN 1998 (ADDING SECTION 9(D) TO THE 1937 ACT MERGING PREVIOUS MODERNIZATION AND DEVELOPMENT PROGRAMS). THE CFP PROVIDES FINANCIAL ASSISTANCE IN THE FORM OF GRANTS TO APPROXIMATELY 2,770 PUBLIC HOUSING AGENCIES (PHAS), SERVING NEARLY ONE MILLION UNITS, IN ALL 50 STATES AND TERRITORIES, TO CARRY OUT CAPITAL AND MANAGEMENT ACTIVITIES INCLUDING THOSE LISTED IN SECTION 9(D)(1) OF THE UNITED STATES HOUSING ACT OF 1937 (1937 ACT). THE MAIN PURPOSE OF THE CFP FORMULA GRANT IS TO FUND PUBLIC HOUSING MODERNIZATION, DEVELOPMENT, MANAGEMENT IMPROVEMENTS, AND THE OTHER ELIGIBLE ACTIVITIES DESCRIBED IN 24 CFR PART 905. ADDITIONAL INFORMATION ON THE PUBLIC HOUSING CAPITAL FUND IS LOCATED ON THE OFFICE OF CAPITAL IMPROVEMENTS WEBSITE: OFFICE OF CAPITAL IMPROVEMENTS | HUD.GOV / U.S. DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT (HUD) ADDITIONAL INFORMATION ON PUBLIC HOUSING FUNDING CAN BE FOUND BY ACCESSING THE WEBSITE BELOW AND REVIEWING THE PUBLIC HOUSING DASHBOARD LINKED UNDER THE “DATA DASHBOARD AND ANALYTICS”. PUBLIC HOUSING | HUD.GOV / U.S. DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT (HUD); ACTIVITIES TO BE PERFORMED: THE PHAS RECEIVE FEDERAL FUNDS FROM THE U.S. DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT (HUD) TO ADMINISTER THE PUBLIC HOUSING FUND. PUBLIC HOUSING CAPITAL FUNDS MAY ONLY BE USED FOR ACTIVITIES THAT ARE DESCRIBED AS ELIGIBLE ACTIVITIES IN 24 CFR 905.200 AND ARE EITHER SPECIFIED IN AN APPROVED 5-YEAR ACTION PLAN OR APPROVED BY HUD FOR EMERGENCY WORK OR WORK NEEDED BECAUSE OF A NON-PRESIDENTIALLY DECLARED NATURAL DISASTER. PUBLIC HOUSING DEVELOPMENT, MODERNIZATION, AND FINANCING ARE THE MAJOR ACTIVITIES TO BE PERFORMED. DEVELOPMENT IS ACTIVITIES AND RELATED COSTS THAT ADD TO (OR SIGNIFICANTLY RECONFIGURE) PUBLIC HOUSING UNITS IN A PHA’S INVENTORY, INCLUDING CONSTRUCTION AND ACQUISITION OF ADDITIONAL PUBLIC HOUSING UNITS, WITH OR WITHOUT REHABILITATION, AND ANY-AND-ALL UNDERTAKINGS NECESSARY FOR PLANNING, DESIGN, FINANCING, LAND ACQUISITION, DEMOLITION, CONSTRUCTION, OR EQUIPMENT OF PUBLIC HOUSING UNITS, AND RELATED BUILDINGS, FACILITIES, AND/OR APPURTENANCES (I.E., NON-DWELLING FACILITIES/SPACES). DEVELOPMENT ALSO INCLUDES ANY MIXED-FINANCE MODERNIZATION, ALL RELEVANT MODERNIZATION USES (OTHER THAN MANAGEMENT IMPROVEMENTS), FINANCING USES, AND DEVELOPMENT OF NON-DWELLING SPACE WHERE SUCH SPACE IS NEEDED TO ADMINISTER, AND IS OF DIRECT BENEFIT TO A PUBLIC HOUSING PROJECT (I.E. HOUSING DEVELOPED, ACQUIRED, OR ASSISTED BY A PHA UNDER THE 1937 ACT, AND THE IMPROVEMENT OF ANY SUCH HOUSING), INCLUDING THE RESIDENTS. FINANCING DEBT AND FINANCING COSTS (E.G., ORIGINATION FEES, INTEREST) INCURRED BY A PHA FOR DEVELOPMENT OR MODERNIZATION OF PUBLIC HOUSING PROJECTS, INCLUDING MIXED-FINANCE DEVELOPMENT, THE CAPITAL FUND FINANCING PROGRAM (CFFP), AND ANY OTHER USE AUTHORIZED UNDER SECTION 30 OF THE 1937 ACT. MODERNIZATION INCLUDES ALL ELIGIBLE ACTIVITIES EXCEPT FOR DEVELOPMENT AND FINANCING. PHYSICAL WORK IS A MAJOR ACTIVITY AND IS WORK THAT IS DONE ON THE PHYSICAL STRUCTURES, SITE, AND GROUNDS OF A PUBLIC HOUSING PROPERTY OR STRUCTURE. MAJOR PHYSICAL ACTIVITIES INCLUDE DEMOLITION, RECONFIGURATION, EMERGENCY ACTIVITIES, ENERGY EFFICIENCY, NON-ROUTINE MAINTENANCE, PLANNED CODE COMPLIANCE, AND VACANCY REDUCTION. THE MEASURABLE OUTCOME OF THIS GRANT IS THAT HUD WILL BE ABLE TO TRACK THE AMOUNT OF DOLLARS SPENT ON IMPROVEMENTS TO THE STRUCTURES, UNITS, COMMON AREAS, UTILITIES, AND OTHER ELIGIBLE ACTIVITIES. ; EXPECTED OUTCOMES: THE EXPECTED OUTCOMES FOR PUBLIC HOUSING CAPITAL FUNDS OF APPROXIMATELY $3.2 BILLION WILL BE PUT INTO THE DEVELOPMENT, MODERNIZATION, AND FINANCING OF NEARLY 1 MILLION PUBLIC HOUSING UNITS ACROSS ALL 50 STATES AND TERRITORIES. THE PUBLIC HOUSING UNITS ARE UPDATED TO BE DECENT, SAFE, SANITARY AND TO COMPLY WITH FEDERAL HOUSING STANDARDS. PHAS CAN ALSO USE A PORTION OF THE CAPITAL FUNDING FOR MANAGEMENT IMPROVEMENTS OR OPERATING ACTIVITIES INCLUDING SAFETY AND SECURITY COSTS.; INTENDED BENEFICIARIES: THE INTENDED BENEFICIARIES FOR PUBLIC HOUSING CAPITAL FUNDS ARE THE LOW-INCOME PUBLIC HOUSING RESIDENTS.; SUBRECIPIENT ACTIVITIES: THE RECIPIENT DOES NOT INTEND TO SUBAWARD FUNDS.

COOPERATIVE EXTENSION PROGRAMS AT 1862 LAND-GRANT INSTITUTIONS - CLEMSON UNIVERSITY

PURPOSE: REHABILITATE TAXIWAY. ACTIVITIES TO BE PERFORMED/EXPECTED OUTCOMES: THIS PROJECT REHABILITATES 6,286 FEET OF THE EXISTING PAVED TAXIWAY B AND CONNECTOR TAXIWAYS B1, B2, B3, C, AND D TO MAINTAIN THE STRUCTURAL INTEGRITY OF THE PAVEMENT AND TO MINIMIZE FOREIGN OBJECT DEBRIS TO EXTEND ITS USEFUL LIFE. THIS PROJECT REHABILITATES 847 FEET OF THE EXISTING PAVED TAXIWAY A TO MAINTAIN THE STRUCTURAL INTEGRITY OF THE PAVEMENT AND TO MINIMIZE FOREIGN OBJECT DEBRIS TO EXTEND ITS USEFUL LIFE. INTENDED BENEFICIARY: THIS GRANT WILL PROVIDE FEDERAL FUNDING FOR AIRPORTS ASSOCIATED WITH MARION, ILLINOIS.

PURPOSE: THE PUBLIC HOUSING CAPITAL FUND PROGRAM (CFP) WAS CREATED BY AN AMENDMENT TO THE 1937 ACT BY THE QUALITY HOUSING AND WORK RESPONSIBILITY ACT (QHWRA) IN 1998 (ADDING SECTION 9(D) TO THE 1937 ACT MERGING PREVIOUS MODERNIZATION AND DEVELOPMENT PROGRAMS). THE CFP PROVIDES FINANCIAL ASSISTANCE IN THE FORM OF GRANTS TO APPROXIMATELY 2,770 PUBLIC HOUSING AGENCIES (PHAS), SERVING NEARLY ONE MILLION UNITS, IN ALL 50 STATES AND TERRITORIES, TO CARRY OUT CAPITAL AND MANAGEMENT ACTIVITIES INCLUDING THOSE LISTED IN SECTION 9(D)(1) OF THE UNITED STATES HOUSING ACT OF 1937 (1937 ACT). THE MAIN PURPOSE OF THE CFP FORMULA GRANT IS TO FUND PUBLIC HOUSING MODERNIZATION, DEVELOPMENT, MANAGEMENT IMPROVEMENTS, AND THE OTHER ELIGIBLE ACTIVITIES DESCRIBED IN 24 CFR PART 905. ADDITIONAL INFORMATION ON THE PUBLIC HOUSING CAPITAL FUND IS LOCATED ON THE OFFICE OF CAPITAL IMPROVEMENTS WEBSITE: OFFICE OF CAPITAL IMPROVEMENTS | HUD.GOV / U.S. DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT (HUD) ADDITIONAL INFORMATION ON PUBLIC HOUSING FUNDING CAN BE FOUND BY ACCESSING THE WEBSITE BELOW AND REVIEWING THE PUBLIC HOUSING DASHBOARD LINKED UNDER THE “DATA DASHBOARD AND ANALYTICS”. PUBLIC HOUSING | HUD.GOV / U.S. DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT (HUD); ACTIVITIES TO BE PERFORMED: THE PHAS RECEIVE FEDERAL FUNDS FROM THE U.S. DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT (HUD) TO ADMINISTER THE PUBLIC HOUSING FUND. PUBLIC HOUSING CAPITAL FUNDS MAY ONLY BE USED FOR ACTIVITIES THAT ARE DESCRIBED AS ELIGIBLE ACTIVITIES IN 24 CFR 905.200 AND ARE EITHER SPECIFIED IN AN APPROVED 5-YEAR ACTION PLAN OR APPROVED BY HUD FOR EMERGENCY WORK OR WORK NEEDED BECAUSE OF A NON-PRESIDENTIALLY DECLARED NATURAL DISASTER. PUBLIC HOUSING DEVELOPMENT, MODERNIZATION, AND FINANCING ARE THE MAJOR ACTIVITIES TO BE PERFORMED. DEVELOPMENT IS ACTIVITIES AND RELATED COSTS THAT ADD TO (OR SIGNIFICANTLY RECONFIGURE) PUBLIC HOUSING UNITS IN A PHA’S INVENTORY, INCLUDING CONSTRUCTION AND ACQUISITION OF ADDITIONAL PUBLIC HOUSING UNITS, WITH OR WITHOUT REHABILITATION, AND ANY-AND-ALL UNDERTAKINGS NECESSARY FOR PLANNING, DESIGN, FINANCING, LAND ACQUISITION, DEMOLITION, CONSTRUCTION, OR EQUIPMENT OF PUBLIC HOUSING UNITS, AND RELATED BUILDINGS, FACILITIES, AND/OR APPURTENANCES (I.E., NON-DWELLING FACILITIES/SPACES). DEVELOPMENT ALSO INCLUDES ANY MIXED-FINANCE MODERNIZATION, ALL RELEVANT MODERNIZATION USES (OTHER THAN MANAGEMENT IMPROVEMENTS), FINANCING USES, AND DEVELOPMENT OF NON-DWELLING SPACE WHERE SUCH SPACE IS NEEDED TO ADMINISTER, AND IS OF DIRECT BENEFIT TO A PUBLIC HOUSING PROJECT (I.E. HOUSING DEVELOPED, ACQUIRED, OR ASSISTED BY A PHA UNDER THE 1937 ACT, AND THE IMPROVEMENT OF ANY SUCH HOUSING), INCLUDING THE RESIDENTS. FINANCING DEBT AND FINANCING COSTS (E.G., ORIGINATION FEES, INTEREST) INCURRED BY A PHA FOR DEVELOPMENT OR MODERNIZATION OF PUBLIC HOUSING PROJECTS, INCLUDING MIXED-FINANCE DEVELOPMENT, THE CAPITAL FUND FINANCING PROGRAM (CFFP), AND ANY OTHER USE AUTHORIZED UNDER SECTION 30 OF THE 1937 ACT. MODERNIZATION INCLUDES ALL ELIGIBLE ACTIVITIES EXCEPT FOR DEVELOPMENT AND FINANCING. PHYSICAL WORK IS A MAJOR ACTIVITY AND IS WORK THAT IS DONE ON THE PHYSICAL STRUCTURES, SITE, AND GROUNDS OF A PUBLIC HOUSING PROPERTY OR STRUCTURE. MAJOR PHYSICAL ACTIVITIES INCLUDE DEMOLITION, RECONFIGURATION, EMERGENCY ACTIVITIES, ENERGY EFFICIENCY, NON-ROUTINE MAINTENANCE, PLANNED CODE COMPLIANCE, AND VACANCY REDUCTION. THE MEASURABLE OUTCOME OF THIS GRANT IS THAT HUD WILL BE ABLE TO TRACK THE AMOUNT OF DOLLARS SPENT ON IMPROVEMENTS TO THE STRUCTURES, UNITS, COMMON AREAS, UTILITIES, AND OTHER ELIGIBLE ACTIVITIES. ; EXPECTED OUTCOMES: THE EXPECTED OUTCOMES FOR PUBLIC HOUSING CAPITAL FUNDS OF APPROXIMATELY $3.2 BILLION WILL BE PUT INTO THE DEVELOPMENT, MODERNIZATION, AND FINANCING OF NEARLY 1 MILLION PUBLIC HOUSING UNITS ACROSS ALL 50 STATES AND TERRITORIES. THE PUBLIC HOUSING UNITS ARE UPDATED TO BE DECENT, SAFE, SANITARY AND TO COMPLY WITH FEDERAL HOUSING STANDARDS. PHAS CAN ALSO USE A PORTION OF THE CAPITAL FUNDING FOR MANAGEMENT IMPROVEMENTS OR OPERATING ACTIVITIES INCLUDING SAFETY AND SECURITY COSTS.; INTENDED BENEFICIARIES: THE INTENDED BENEFICIARIES FOR PUBLIC HOUSING CAPITAL FUNDS ARE THE LOW-INCOME PUBLIC HOUSING RESIDENTS.; SUBRECIPIENT ACTIVITIES: THE RECIPIENT DOES NOT INTEND TO SUBAWARD FUNDS.

5307 VEHICLE REPLACEMENT FUNDS FROM SCDOT - CITY OF CLEMSON DBA CLEMSON AREA TRANSIT

FW-HTF-RL: PREPARING THE FUTURE WORKFORCE FOR THE ERA OF AUTOMATED VEHICLES

CLEMSON UNIVERSITY HEALTHY OPTIONS PROGRAM - SC HAS THE 13TH HIGHEST RATE OF OBESITY IN THE NATION WITH 24 (52%) OF SC’S 46 COUNTIES EXPERIENCING ADULT OBESITY RATES OVER 40%. THIS PROPOSAL TARGETS 10 OF THE ELIGIBLE COUNTIES WHERE SIGNIFICANT HEALTH DISPARITY EXISTS INCLUDING MARLBORO, DILLON, MARION, DARLINGTON, FLORENCE, LEE, ORANGEBURG, ALLENDALE, BAMBERG, AND HAMPTON; COUNTIES CHARACTERIZED BY RURALITY, HIGH PERCENTAGES OF MINORITY POPULATIONS, AND HIGH RATES OF POVERTY AND UNEMPLOYMENT. PARISI AND GRIFFIN BRING MORE THAN 30 YEARS COMBINED EXPERIENCE TO THIS PROJECT INCLUDING EXPERIENCE AS CO-PIS FOR THE 2018-CDC-HOP GRANT WHICH HAS SHOWN EXCELLENT RESULTS. TOGETHER, WITH A TEAM OF EVALUATION, TOPIC, AND EXTENSION EXPERTS AND A WORKFORCE OF 10 COUNTY-LEVEL EXTENSION AGENTS, WE WILL PLAN, SUPERVISE, IMPLEMENT AND EVALUATE THE 4 EVIDENCE-BASED STRATEGIES IDENTIFIED IN THE HOP LOGIC MODEL IN SC. FOR STRATEGY 1A., WE WILL TRAIN INDIVIDUALS FROM TARGET ORGANIZATIONS THROUGH EXTENSION NUTRITION, FOOD AND DISTRIBUTION TRAINING AND CERTIFICATION ACTIVITIES THAT PROMOTE IMPLEMENTATION OF NUTRITION STANDARDS AND BEHAVIORAL DESIGN IN FOOD SERVICE AND DISTRIBUTION LOCATIONS. WE WILL EXPAND WORK FROM THE 2018-HOP GRANT IN MARION, LEE, AND HAMPTON COUNTIES, AND IMPLEMENT POLICIES IN FAITH-BASED FOOD PANTRIES FOR HEALTHY FOOD STANDARDS ADOPTION TO QUALIFY AS SNAP VENDORS AND BECOME LOCAL PRODUCER FOOD HUBS. FOR STRATEGY 1B, WE WILL EDUCATE HEALTHCARE PROVIDERS ON REFERRAL TO VOUCHER PROGRAMS AND FOOD SECURITY ASSISTANCE PROGRAMS. PROVIDERS WILL BE ENCOURAGED TO ADOPT ROUTINE SCREENING TOOLS FOR FOOD INSECURITY, AND WE WILL ESTABLISH COMMUNITY-CLINICAL LINKAGES WITH REFERRAL PATHWAYS TO EXTENSION AGENTS FOR PATIENT RESOURCE NAVIGATION RELATED TO HEALTHY FOOD ACCESS POINTS. WE WILL WORK WITH PROVIDERS ON PRODUCE PRESCRIPTIONS AND ASSIST PATIENTS RECEIVING THESE WITH HEALTHY FOOD PROCUREMENT TO SUPPORT CHRONIC DISEASE PREVENTION AND SELF-MANAGEMENT. WE WILL ADDRESS STRATEGY 2 BY PARTNERING WITH CITY AND COUNTY GOVERNMENTS AND A CITY PLANNING CONSULTANT TO ASSESS EXISTING PLANS IN EACH OF THE 10 COUNTIES. EXTENSION AGENTS AND STEALTH TEAMS FROM LOCAL COALITIONS, WILL ADVOCATE FOR CHANGES THAT IMPROVE WALKABILITY WITH COUNTY ADMINISTRATORS AND COUNCILS. STRATEGY 3 WILL CREATE CONNECTIONS BETWEEN LOCAL MINORITY FARMERS AND ECES IN TARGET COUNTIES FOR PRODUCE BOX DISTRIBUTION. STRATEGY 4, FHWP, WILL BE ROLLED OUT INTO TARGET COUNTIES OVER THE DURATION OF THE GRANT. FORMAL PARTNERSHIPS WITH HEALTHCARE PARTNERS AND REFERRAL PATHWAYS BETWEEN PROVIDERS AND COUNTY-LEVEL EXTENSION AGENTS WILL BE ESTABLISHED. THE COLLABORATIONS THAT HAVE BEEN FOSTERED BETWEEN DEPARTMENTS, COLLEGES, AND FACULTY AT CLEMSON WILL BE LEVERAGED TO MAXIMIZE EXPERTISE ON TOPICS RELATED TO HOP STRATEGIES. EXISTING EXTERNAL HEALTH SYSTEM PARTNERSHIPS WILL FACILITATE COMMUNITY-CLINICAL LINKAGES AND PRODUCE BOX DISTRIBUTION POINTS AT HEALTH FAIRS IN THE TARGET COUNTIES. THEY WILL SERVE AS REFERRAL SOURCES FOR INDIVIDUALS SCREENED AT RISK FOR FOOD INSECURITY AND YOUTH DIAGNOSED WITH OBESITY TO EXTENSION AGENTS FOR RESOURCE AND FHWP NAVIGATION. WE WILL EMPLOY EQUITY-FOCUSED AND MIXED-METHODS APPROACHES IN COLLECTING AND INTERPRETING PROCESS AND OUTCOME MEASURES. THE PROCESS EVALUATION WILL ASSESS OUTPUTS AND SHORT-TERM OUTCOMES BY FOCUSING ON IMPLEMENTATION OF ACTIVITIES DESCRIBED IN THE WORK PLAN AND CONTEXTUAL FACTORS ASSOCIATED WITH HEALTH INEQUITIES AND IMPLEMENTATION SUCCESSES OR STRUGGLES. PROCESS AND OUTCOME EVALUATION WILL BE A HIGH PROJECT PRIORITY AND EVALUATION SPECIALISTS WILL BE ENGAGED TO COMPLETE ALL EVALUATION ACTIVITIES. THE PROJECT WILL ACHIEVE DESIRED OUTCOMES: INCREASED NUMBER OF SETTINGS THAT INCREASE ACCESS TO HEALTHIER FOODS; INCREASED NUMBER OF POLICIES, PLANS, OR COMMUNITY DESIGN CHANGES THAT INCREASE ACCESS TO PHYSICAL ACTIVITY; INCREASED NUMBER OF ECE CENTER PROGRAMS THAT ARE IMPACTED BY FARM TO ECE CENTER IMPROVEMENTS; AND INCREASED NUMBER OF SUPPORTS FOR IMPLEMENTATION OF FHWM PROGRAMS.

MEDIAL ARTERIAL CALCIFICATION: MECHANISMS AND THERAPY

COMMUNITY DEVELOPMENT BLOCK GRANTS/ENTITLEMENT GRANTS

PUBLIC HOUSING CAPITAL FUND

FUNCTIONALLY DESIGNED ULTRA-LIGHTWEIGHT CARBON FIBER REINFORCED THERMOPLASTIC COMPOSITES DOOR ASSEMBLY

SMITH LEVER 3B&C FUNDS

PUBLIC HOUSING CAPITAL FUND

EFRI-CBE: EMERGING FRONTIERS IN 3-D BREAST CANCER TISSUE TEST SYSTEMS

PURPOSE: THE COMMUNITY DEVELOPMENT BLOCK GRANT (CDBG) PROGRAM PROVIDES ANNUAL GRANTS ON A FORMULA BASIS TO STATES, CITIES, AND COUNTIES TO DEVELOP VIABLE URBAN COMMUNITIES BY PROVIDING DECENT HOUSING AND A SUITABLE LIVING ENVIRONMENT, AND BY EXPANDING ECONOMIC OPPORTUNITIES, PRINCIPALLY FOR LOW- AND MODERATE-INCOME PERSONS. THE PROGRAM IS AUTHORIZED UNDER TITLE 1 OF THE HOUSING AND COMMUNITY DEVELOPMENT ACT OF 1974, PUBLIC LAW 93-383, AS AMENDED 42 U.S.C. 5301 ET SEQ. THE CDBG PROGRAM COVERS FOUR DISTINCT PROGRAMS, EACH WITH THEIR OWN SET OF GOVERNING REGULATIONS: CDBG ENTITLEMENT, CDBG NON-ENTITLED COUNTIES IN HAWAII, CDBG INSULAR AREAS, AND STATE CDBG. IN THE CDBG ENTITLEMENT PROGRAM, HUD AWARDS GRANTS TO ENTITLEMENT COMMUNITY GRANTEES TO CARRY OUT A WIDE RANGE OF COMMUNITY DEVELOPMENT ACTIVITIES. ENTITLEMENT COMMUNITIES DEVELOP THEIR OWN PROGRAMS AND FUNDING PRIORITIES. IN THE CDBG NON-ENTITLED COUNTIES IN HAWAII PROGRAM, THREE COUNTIES QUALIFY: HAWAII, KAUAI, AND MAUI. THE FY 2004 APPROPRIATIONS ACT REQUIRED THE GOVERNOR OF HAWAII TO DECIDE IF THE STATE WISHED TO PARTICIPATE IN THE STATE CDBG PROGRAM BY JULY 31, 2004. THE STATE MADE THE DECISION NOT TO PARTICIPATE IN THE PROGRAM. AS A RESULT OF THIS DECISION HUD'S HONOLULU FIELD OFFICE ADMINISTERS THE NON-ENTITLED GRANTS IN HAWAII. FUNDS ARE ALLOCATED USING A FORMULA BASED ON POPULATION, POVERTY, AND HOUSING OVERCROWDING, WITH THE POVERTY FACTOR CARRYING A DOUBLE WEIGHT. FOR THE CDBG INSULAR AREAS PROGRAM, HUD ANNUALLY ALLOCATES CDBG GRANTS TO FOUR DESIGNATED AREAS: AMERICAN SAMOA; GUAM; NORTHERN MARIANA ISLANDS; AND THE U.S. VIRGIN ISLANDS. THE FUNDS ARE ALLOCATED IN PROPORTION TO THE POPULATIONS OF THE ELIGIBLE TERRITORIES. THE PROGRAM IS ADMINISTERED BY HUD'S FIELD OFFICES IN PUERTO RICO AND HAWAII. UNDER THE STATE CDBG PROGRAM, STATES PASS THROUGH CDBG GRANTS TO UNITS OF GENERAL LOCAL GOVERNMENT. ANNUALLY, EACH STATE DEVELOPS FUNDING PRIORITIES AND CRITERIA FOR SELECTING PROJECTS. SINCE STATES ARE IN THE BEST POSITION TO KNOW, AND TO RESPOND TO, THE NEEDS OF LOCAL GOVERNMENTS, CONGRESS AMENDED THE HOUSING AND COMMUNITY DEVELOPMENT ACT OF 1974 (HCD ACT) IN 1981 TO GIVE EACH STATE THE OPPORTUNITY TO ADMINISTER CDBG FUNDS FOR NON-ENTITLEMENT AREAS. NON-ENTITLEMENT AREAS INCLUDE THOSE UNITS OF GENERAL LOCAL GOVERNMENT WHICH DO NOT RECEIVE CDBG FUNDS DIRECTLY FROM HUD. GENERALLY, NON-ENTITLEMENT AREAS ARE CITIES WITH POPULATIONS OF LESS THAN 50,000 (EXCEPT CITIES THAT ARE DESIGNATED PRINCIPAL CITIES OF METROPOLITAN STATISTICAL AREAS), AND COUNTIES WITH POPULATIONS OF LESS THAN 200,000. CURRENT CDBG AWARDS AND ALLOCATIONS ARE INCLUDED IN THIS LIST OF HUD COMMUNITY PLANNING AND DEVELOPMENT (CPD) AWARDS AND ALLOCATIONS LOCATED AT: HTTPS://WWW.HUDEXCHANGE.INFO/GRANTEES/ALLOCATIONS-AWARDS/; ACTIVITIES TO BE PERFORMED: CDBG FUNDS MAY BE USED FOR ACTIVITIES WHICH INCLUDE, BUT ARE NOT LIMITED TO: ACQUISITION OF REAL PROPERTY; RELOCATION AND DEMOLITION; REHABILITATION OF RESIDENTIAL AND NON-RESIDENTIAL STRUCTURES; CONSTRUCTION OF PUBLIC FACILITIES AND IMPROVEMENTS, SUCH AS WATER AND SEWER FACILITIES, STREETS, NEIGHBORHOOD CENTERS, AND THE CONVERSION OF SCHOOL BUILDINGS FOR ELIGIBLE PURPOSES; PUBLIC SERVICES, WITHIN CERTAIN LIMITS; ACTIVITIES RELATING TO ENERGY CONSERVATION AND RENEWABLE ENERGY RESOURCES; PROVISION OF ASSISTANCE TO PROFIT-MOTIVATED BUSINESSES TO CARRY OUT ECONOMIC DEVELOPMENT AND JOB CREATION/RETENTION ACTIVITIES. EACH ACTIVITY MUST MEET ONE OF THE FOLLOWING NATIONAL OBJECTIVES FOR THE PROGRAM: BENEFIT LOW- AND MODERATE-INCOME PERSONS, PREVENTION OR ELIMINATION OF SLUMS OR BLIGHT, OR ADDRESS COMMUNITY DEVELOPMENT NEEDS HAVING A PARTICULAR URGENCY BECAUSE EXISTING CONDITIONS POSE A SERIOUS AND IMMEDIATE THREAT TO THE HEALTH OR WELFARE OF THE COMMUNITY FOR WHICH OTHER FUNDING IS NOT AVAILABLE. GENERALLY, THE FOLLOWING TYPES OF ACTIVITIES ARE INELIGIBLE: ACQUISITION, CONSTRUCTION, OR RECONSTRUCTION OF BUILDINGS FOR THE GENERAL CONDUCT OF GOVERNMENT; POLITICAL ACTIVITIES; CERTAIN INCOME PAYMENTS; CONSTRUCTION OF NEW HOUSING (WITH SOME EXCEPTIONS). UNDER THE STATE CDBG PROGRAM, STATES MAY USE $100,000 PLUS UP TO A MAXIMUM OF THREE PERCENT OF ITS CDBG ALLOCATION. AMOUNTS EXPENDED ON ADMINISTRATION IN EXCESS OF $100,000 MUST BE MATCHED. STATES MAY EXPEND UP TO THREE PERCENT OF THEIR CDBG ALLOCATION ON TECHNICAL ASSISTANCE ACTIVITIES. HOWEVER, THE TOTAL A STATE SPENDS ON BOTH ADMINISTRATIVE AND TECHNICAL ASSISTANCE EXPENSES MAY NOT EXCEED $100,000 PLUS THREE PERCENT OF THE STATE'S ALLOCATION. CPD HAS DEVELOPED PROFILES THAT DISPLAY GRANTEE-REPORTED ACCOMPLISHMENTS FOR SELECTED HOUSING, ECONOMIC DEVELOPMENT, PUBLIC IMPROVEMENT, AND PUBLIC SERVICE ACTIVITIES. PROFILES FOR GRANTEES WILL VARY, AS GRANTEES HAVE FLEXIBILITY IN DETERMINING THE HOUSING, ECONOMIC, AND COMMUNITY DEVELOPMENT ACTIVITIES THEY CARRY OUT WITH CDBG FUNDS. THE MOST RECENT ACCOMPLISHMENTS CAN BE VIEWED WITHIN THE NATIONAL ACCOMPLISHMENT REPORTS LOCATED AT: HTTPS://WWW.HUDEXCHANGE.INFO/PROGRAMS/CDBG/CDBG-ACCOMPLISHMENT-REPORTS/; EXPECTED OUTCOMES: THE CDBG PROGRAM REINFORCES SEVERAL IMPORTANT VALUES AND PRINCIPLES OF COMMUNITY DEVELOPMENT: PROGRAM FLEXIBILITY TO EMPOWER PEOPLE AND COMMUNITIES TO DESIGN AND IMPLEMENT STRATEGIES TAILORED TO THEIR OWN NEEDS AND PRIORITIES; AN EMPHASIS ON CONSOLIDATED PLANNING THAT EXPANDS AND STRENGTHENS PARTNERSHIPS AMONG ALL LEVELS OF GOVERNMENT AND THE PRIVATE SECTOR IN ENHANCING COMMUNITY DEVELOPMENT; TECHNICAL ASSISTANCE ACTIVITIES AND SET-ASIDE FOR GRANTEES TO BUILD THE CAPACITY OF THESE PARTNERS. EACH CDBG GRANTEE’S EXPECTED OUTCOMES ARE DESCRIBED AS GOALS IN THEIR CONSOLIDATED PLAN. THE MOST RECENT CONSOLIDATED PLANS CAN BE VIEWED AT: HTTPS://WWW.HUDEXCHANGE.INFO/GRANTEES/REPORTS/#CONSOLIDATED-PLANS-ANNUAL-ACTION-PLANS-AND-CAPERS; INTENDED BENEFICIARIES: OVER A 1, 2, OR 3-YEAR PERIOD, AS SELECTED BY THE GRANTEE, NOT LESS THAN 70 PERCENT OF CDBG FUNDS MUST BE USED FOR ACTIVITIES THAT BENEFIT LOW- AND MODERATE-INCOME PERSONS. HUD DOES NOT PROVIDE CDBG ASSISTANCE DIRECTLY TO INDIVIDUALS, BUSINESSES, NONPROFIT OR ORGANIZATIONS OR OTHER NON-GOVERNMENTAL ENTITIES. INDIVIDUALS WHO ARE INTERESTED IN PARTICIPATING IN THIS PROGRAM, SHOULD CONTACT THEIR LOCAL MUNICIPAL OR COUNTY OFFICIALS TO FIND OUT HOW THE PROGRAM OPERATES IN THEIR COMMUNITY. PARTICIPATION REQUIREMENTS MAY DIFFER FROM ONE GRANTEE TO ANOTHER. WITH THE EXCEPTION OF THE STATE CDBG PROGRAM, THE LOCAL GOVERNMENT GRANTEE ADMINISTERS THE CDBG PROGRAM AND DETERMINES WHICH LOCAL PROJECTS RECEIVE FUNDING. ELIGIBLE GRANTEES ARE AS FOLLOWS: PRINCIPAL CITIES OF METROPOLITAN STATISTICAL AREAS (MSAS); OTHER METROPOLITAN CITIES WITH POPULATIONS OF AT LEAST 50,000; QUALIFIED URBAN COUNTIES WITH POPULATIONS OF AT LEAST 200,000 (EXCLUDING THE POPULATION OF ENTITLED CITIES); STATES AND INSULAR AREAS. THE DISTRICT OF COLUMBIA IS FUNDED UNDER THE CDBG ENTITLEMENT PROGRAM. THE STATE OF HAWAII DOES NOT PARTICIPATE, AND HUD ALLOCATES THE STATE'S SHARE OF FUNDS TO THE THREE HAWAII NON-ENTITLED COUNTIES. THE STATES ADMINISTER CDBG FUNDS IN THE STATE CDBG PROGRAM. SINCE STATES ARE IN THE BEST POSITION TO KNOW, AND TO RESPOND TO, THE NEEDS OF LOCAL GOVERNMENTS, CONGRESS AMENDED THE HOUSING AND COMMUNITY DEVELOPMENT ACT OF 1974 (HCD ACT) IN 1981 TO GIVE EACH STATE THE OPPORTUNITY TO ADMINISTER CDBG FUNDS FOR NON-ENTITLEMENT AREAS.; SUBRECIPIENT ACTIVITIES: THE SUBRECIPIENT ACTIVITIES ARE UNKNOWN AT THE TIME OF AWARD.

THE PURPOSE OF THIS AWARD IS TO IMPLEMENT THE KOSOVO SMALL AND MEDIUM SIZE ENTERPRISE (SME) COMMERCIAL FINANCE FUND PROGRAM.

DEVELOPMENT AND DEMONSTRATION OF A MEDIUM-DUTY OFF-ROAD DME ENGINE WITH A COMBUSTION RECIPE FOR ULTRA-LOW NOX THE OBJECTIVE OF THE PROJECT IS TO DEMONSTRATE A TRANSIENT-CAPABLE MEDIUM-DUTY OFF-ROAD ENGINE FUELED BY RENEWABLE DIMETHYL ETHER (DME) WITH A COMBUSTION RECIPE DESIGNED TO PROVIDE LOW NOX OPERATION WITHOUT COMPROMISING EFFICIENCY.

CLEMSON UNIVERSITY 15 MEGAWATT HARDWARE-IN-THE-LOOP (HIL) GRID SIMULATOR

ENGLISH LEARNER INSTRUCTION: BUILDING CAPACITY THROUGH DESIGN

MECHANISTIC PHARMACODYNAMIC MODELING FOR DRUG COMBINATION RESPONSES - ABSTRACT – MECHANISTIC PHARMACODYNAMIC MODELING FOR DRUG COMBINATIONS MOST INDUSTRIES SIMULATE DESIGN OPTIONS BEFORE IMPLEMENTATION, BUT THIS IS RARELY POSSIBLE IN THE PHARMACEUTICAL AND MEDICAL INDUSTRIES. AN IMPORTANT GAP IS UNBIASED DRUG COMBINATION RESPONSE PREDICTIONS, WHICH IS EXPERIMENTALLY IMPRACTICAL. A LONG-TERM VISION OF OUR LAB IS IMPROVING DRUG DEVELOPMENT AND PRECISION MEDICINE BY BUILDING “MECHANISTIC PHARMACODYNAMIC MODELS” THAT CAN SIMULATE DRUG COMBINATION RESPONSES. SUCH MODELS INFUSE PHARMACOLOGY CONCEPTS WITH PHYSICS AND ENGINEERING APPROACHES TO DESCRIBE CAUSAL, QUANTITATIVE, AND DYNAMIC MECHANISMS UNDERLYING DRUG RESPONSE. A FOUNDATIONAL PREMISE IS THAT CAPTURING (I) MECHANISTIC, CAUSAL NETWORK STRUCTURE, (II) DOSE-RESPONSE, (III) DYNAMICS, AND (IV) CELL-CELL VARIABILITY IS NECESSARY TO IMPROVE MANY COMBINATION RESPONSE PREDICTIONS. HERE, WE STUDY HOW DRUG COMBINATIONS AFFECT SINGLE-CELL PROLIFERATION AND DEATH FATES BY MERGING THEORETICAL AND EXPERIMENTAL INNOVATION. THE FIRST PROJECT BUILDS ON OUR RECENT AND ONE OF THE MOST COMPREHENSIVE MECHANISTIC MODELS FOR REGULATION OF SINGLE-CELL PROLIFERATION AND DEATH DYNAMICS. WE WILL LEVERAGE OUR INVOLVEMENT WITH A RECENT LINCS CONSORTIUM EFFORT THAT GENERATED A DEEP MOLECULAR CHARACTERIZATION OF PERTURBATION RESPONSE DYNAMICS, INCLUDING DOSE RESPONSES TO 8 DRUGS. WE WILL INTEGRATE NETWORK BIOLOGY WITH MECHANISTIC MODELS USING NEW APPROACHES TO OBTAIN CANDIDATE MODELS THAT ARE CONSISTENT WITH THIS DATASET, AND EXPERIMENTALLY TEST DRUG COMBINATION PREDICTIONS FOR THE 8 DRUGS. THIS WILL FOR THE FIRST TIME ADDRESS THE PREDICTION OF A COMPREHENSIVE SET OF DRUG COMBINATION RESPONSES ACROSS VARIED MECHANISMS OF ACTION RELYING ON CAUSAL BIOCHEMICAL REASONING AND ALSO IDENTIFY NOVEL MECHANISMS OF SIGNALING AND DRUG RESPONSE THROUGH ITERATIVE MODEL REFINEMENT AND EXPERIMENTAL VALIDATION. THE SECOND PROJECT BUILDS ON OUR RECENTLY DEVELOPED EXPERIMENTAL APPROACH FOR FLUORESCENCE MULTIPLEXING CALLED MUSIC. WE PROPOSE THAT MUSIC CAN ENABLE HIGH-DIMENSIONAL GENETIC INTERACTION SCREENING IN SINGLE MAMMALIAN CELLS, WHICH IS NOT YET POSSIBLE BUT WOULD BE TRANSFORMATIVE. WE WILL TEST THE APPROACH BY EVALUATING GENETIC INTERACTIONS BETWEEN A RECENTLY CURATED SET OF 667 GENE TARGETS OF 1,578 FDA-APPROVED DRUGS. THIS WORK WILL NOMINATE NEW NETWORK STRUCTURES NOT ONLY FOR USE IN THE FIRST PROJECT, BUT ALSO MORE GENERALLY. THE THIRD PROJECT ALSO LEVERAGES THE ABOVE MECHANISTIC MODEL BUT PIVOTS ACROSS CELL LINES WITH CANCER CELL LINE ENCYCLOPEDIA DATA FOR 1,132 CELL LINES AND 24 DRUGS. AN INNOVATIVE AND FOUNDATIONAL FEATURE OF OUR MODEL IS THAT IT INGESTS MULTI-OMIC DATA TO CREATE A CELL LINE-SPECIFIC CONTEXT THROUGH “INITIALIZATION”. WE WILL GENERATE 1,132 MODEL VARIANTS WITH CELL LINE-SPECIFIC PROFILES AND EVALUATE PREDICTIVE CAPACITY FOR SINGLE AND PRIORITIZED DRUG COMBINATION RESPONSES. THIS PROJECT WILL ESTABLISH PERFORMANCE OF THE CURRENT MODELS, IDENTIFY CRITICAL MODELING GAPS FOR IMPROVING PREDICTIONS, SUGGEST NEW POTENTIALLY EFFECTIVE DRUG COMBINATIONS, AND ELUCIDATE MECHANISMS UNDERLYING SYNERGY. OVERALL, THESE PROJECTS WILL PRODUCE NEXT-GENERATION PHARMACODYNAMIC MODELS THAT MOVE TOWARDS FILLING THE DRUG COMBINATION PREDICTION GAP THAT HINDERS DRUG DEVELOPMENT AND PRECISION MEDICINE.

THE HATCH ACT OF 1887 (REGULAR RESEARCH) - CLEMSON UNIVERSITY

RTG: CODING THEORY, CRYPTOGRAPHY, AND NUMBER THEORY

PURPOSE: THE COMMUNITY DEVELOPMENT BLOCK GRANT (CDBG) PROGRAM PROVIDES ANNUAL GRANTS ON A FORMULA BASIS TO STATES, CITIES, AND COUNTIES TO DEVELOP VIABLE URBAN COMMUNITIES BY PROVIDING DECENT HOUSING AND A SUITABLE LIVING ENVIRONMENT, AND BY EXPANDING ECONOMIC OPPORTUNITIES, PRINCIPALLY FOR LOW- AND MODERATE-INCOME PERSONS. THE PROGRAM IS AUTHORIZED UNDER TITLE 1 OF THE HOUSING AND COMMUNITY DEVELOPMENT ACT OF 1974, PUBLIC LAW 93-383, AS AMENDED 42 U.S.C. 5301 ET SEQ. THE CDBG PROGRAM COVERS FOUR DISTINCT PROGRAMS, EACH WITH THEIR OWN SET OF GOVERNING REGULATIONS: CDBG ENTITLEMENT, CDBG NON-ENTITLED COUNTIES IN HAWAII, CDBG INSULAR AREAS, AND STATE CDBG. IN THE CDBG ENTITLEMENT PROGRAM, HUD AWARDS GRANTS TO ENTITLEMENT COMMUNITY GRANTEES TO CARRY OUT A WIDE RANGE OF COMMUNITY DEVELOPMENT ACTIVITIES. ENTITLEMENT COMMUNITIES DEVELOP THEIR OWN PROGRAMS AND FUNDING PRIORITIES. IN THE CDBG NON-ENTITLED COUNTIES IN HAWAII PROGRAM, THREE COUNTIES QUALIFY: HAWAII, KAUAI, AND MAUI. THE FY 2004 APPROPRIATIONS ACT REQUIRED THE GOVERNOR OF HAWAII TO DECIDE IF THE STATE WISHED TO PARTICIPATE IN THE STATE CDBG PROGRAM BY JULY 31, 2004. THE STATE MADE THE DECISION NOT TO PARTICIPATE IN THE PROGRAM. AS A RESULT OF THIS DECISION HUD'S HONOLULU FIELD OFFICE ADMINISTERS THE NON-ENTITLED GRANTS IN HAWAII. FUNDS ARE ALLOCATED USING A FORMULA BASED ON POPULATION, POVERTY, AND HOUSING OVERCROWDING, WITH THE POVERTY FACTOR CARRYING A DOUBLE WEIGHT. FOR THE CDBG INSULAR AREAS PROGRAM, HUD ANNUALLY ALLOCATES CDBG GRANTS TO FOUR DESIGNATED AREAS: AMERICAN SAMOA; GUAM; NORTHERN MARIANA ISLANDS; AND THE U.S. VIRGIN ISLANDS. THE FUNDS ARE ALLOCATED IN PROPORTION TO THE POPULATIONS OF THE ELIGIBLE TERRITORIES. THE PROGRAM IS ADMINISTERED BY HUD'S FIELD OFFICES IN PUERTO RICO AND HAWAII. UNDER THE STATE CDBG PROGRAM, STATES PASS THROUGH CDBG GRANTS TO UNITS OF GENERAL LOCAL GOVERNMENT. ANNUALLY, EACH STATE DEVELOPS FUNDING PRIORITIES AND CRITERIA FOR SELECTING PROJECTS. SINCE STATES ARE IN THE BEST POSITION TO KNOW, AND TO RESPOND TO, THE NEEDS OF LOCAL GOVERNMENTS, CONGRESS AMENDED THE HOUSING AND COMMUNITY DEVELOPMENT ACT OF 1974 (HCD ACT) IN 1981 TO GIVE EACH STATE THE OPPORTUNITY TO ADMINISTER CDBG FUNDS FOR NON-ENTITLEMENT AREAS. NON-ENTITLEMENT AREAS INCLUDE THOSE UNITS OF GENERAL LOCAL GOVERNMENT WHICH DO NOT RECEIVE CDBG FUNDS DIRECTLY FROM HUD. GENERALLY, NON-ENTITLEMENT AREAS ARE CITIES WITH POPULATIONS OF LESS THAN 50,000 (EXCEPT CITIES THAT ARE DESIGNATED PRINCIPAL CITIES OF METROPOLITAN STATISTICAL AREAS), AND COUNTIES WITH POPULATIONS OF LESS THAN 200,000. CURRENT CDBG AWARDS AND ALLOCATIONS ARE INCLUDED IN THIS LIST OF HUD COMMUNITY PLANNING AND DEVELOPMENT (CPD) AWARDS AND ALLOCATIONS LOCATED AT: HTTPS://WWW.HUDEXCHANGE.INFO/GRANTEES/ALLOCATIONS-AWARDS/; ACTIVITIES TO BE PERFORMED: CDBG FUNDS MAY BE USED FOR ACTIVITIES WHICH INCLUDE, BUT ARE NOT LIMITED TO: ACQUISITION OF REAL PROPERTY; RELOCATION AND DEMOLITION; REHABILITATION OF RESIDENTIAL AND NON-RESIDENTIAL STRUCTURES; CONSTRUCTION OF PUBLIC FACILITIES AND IMPROVEMENTS, SUCH AS WATER AND SEWER FACILITIES, STREETS, NEIGHBORHOOD CENTERS, AND THE CONVERSION OF SCHOOL BUILDINGS FOR ELIGIBLE PURPOSES; PUBLIC SERVICES, WITHIN CERTAIN LIMITS; ACTIVITIES RELATING TO ENERGY CONSERVATION AND RENEWABLE ENERGY RESOURCES; PROVISION OF ASSISTANCE TO PROFIT-MOTIVATED BUSINESSES TO CARRY OUT ECONOMIC DEVELOPMENT AND JOB CREATION/RETENTION ACTIVITIES. EACH ACTIVITY MUST MEET ONE OF THE FOLLOWING NATIONAL OBJECTIVES FOR THE PROGRAM: BENEFIT LOW- AND MODERATE-INCOME PERSONS, PREVENTION OR ELIMINATION OF SLUMS OR BLIGHT, OR ADDRESS COMMUNITY DEVELOPMENT NEEDS HAVING A PARTICULAR URGENCY BECAUSE EXISTING CONDITIONS POSE A SERIOUS AND IMMEDIATE THREAT TO THE HEALTH OR WELFARE OF THE COMMUNITY FOR WHICH OTHER FUNDING IS NOT AVAILABLE. GENERALLY, THE FOLLOWING TYPES OF ACTIVITIES ARE INELIGIBLE: ACQUISITION, CONSTRUCTION, OR RECONSTRUCTION OF BUILDINGS FOR THE GENERAL CONDUCT OF GOVERNMENT; POLITICAL ACTIVITIES; CERTAIN INCOME PAYMENTS; CONSTRUCTION OF NEW HOUSING (WITH SOME EXCEPTIONS). UNDER THE STATE CDBG PROGRAM, STATES MAY USE $100,000 PLUS UP TO A MAXIMUM OF THREE PERCENT OF ITS CDBG ALLOCATION. AMOUNTS EXPENDED ON ADMINISTRATION IN EXCESS OF $100,000 MUST BE MATCHED. STATES MAY EXPEND UP TO THREE PERCENT OF THEIR CDBG ALLOCATION ON TECHNICAL ASSISTANCE ACTIVITIES. HOWEVER, THE TOTAL A STATE SPENDS ON BOTH ADMINISTRATIVE AND TECHNICAL ASSISTANCE EXPENSES MAY NOT EXCEED $100,000 PLUS THREE PERCENT OF THE STATE'S ALLOCATION. CPD HAS DEVELOPED PROFILES THAT DISPLAY GRANTEE-REPORTED ACCOMPLISHMENTS FOR SELECTED HOUSING, ECONOMIC DEVELOPMENT, PUBLIC IMPROVEMENT, AND PUBLIC SERVICE ACTIVITIES. PROFILES FOR GRANTEES WILL VARY, AS GRANTEES HAVE FLEXIBILITY IN DETERMINING THE HOUSING, ECONOMIC, AND COMMUNITY DEVELOPMENT ACTIVITIES THEY CARRY OUT WITH CDBG FUNDS. THE MOST RECENT ACCOMPLISHMENTS CAN BE VIEWED WITHIN THE NATIONAL ACCOMPLISHMENT REPORTS LOCATED AT: HTTPS://WWW.HUDEXCHANGE.INFO/PROGRAMS/CDBG/CDBG-ACCOMPLISHMENT-REPORTS/; EXPECTED OUTCOMES: THE CDBG PROGRAM REINFORCES SEVERAL IMPORTANT VALUES AND PRINCIPLES OF COMMUNITY DEVELOPMENT: PROGRAM FLEXIBILITY TO EMPOWER PEOPLE AND COMMUNITIES TO DESIGN AND IMPLEMENT STRATEGIES TAILORED TO THEIR OWN NEEDS AND PRIORITIES; AN EMPHASIS ON CONSOLIDATED PLANNING THAT EXPANDS AND STRENGTHENS PARTNERSHIPS AMONG ALL LEVELS OF GOVERNMENT AND THE PRIVATE SECTOR IN ENHANCING COMMUNITY DEVELOPMENT; TECHNICAL ASSISTANCE ACTIVITIES AND SET-ASIDE FOR GRANTEES TO BUILD THE CAPACITY OF THESE PARTNERS. EACH CDBG GRANTEE’S EXPECTED OUTCOMES ARE DESCRIBED AS GOALS IN THEIR CONSOLIDATED PLAN. THE MOST RECENT CONSOLIDATED PLANS CAN BE VIEWED AT: HTTPS://WWW.HUDEXCHANGE.INFO/GRANTEES/REPORTS/#CONSOLIDATED-PLANS-ANNUAL-ACTION-PLANS-AND-CAPERS; INTENDED BENEFICIARIES: OVER A 1, 2, OR 3-YEAR PERIOD, AS SELECTED BY THE GRANTEE, NOT LESS THAN 70 PERCENT OF CDBG FUNDS MUST BE USED FOR ACTIVITIES THAT BENEFIT LOW- AND MODERATE-INCOME PERSONS. HUD DOES NOT PROVIDE CDBG ASSISTANCE DIRECTLY TO INDIVIDUALS, BUSINESSES, NONPROFIT OR ORGANIZATIONS OR OTHER NON-GOVERNMENTAL ENTITIES. INDIVIDUALS WHO ARE INTERESTED IN PARTICIPATING IN THIS PROGRAM, SHOULD CONTACT THEIR LOCAL MUNICIPAL OR COUNTY OFFICIALS TO FIND OUT HOW THE PROGRAM OPERATES IN THEIR COMMUNITY. PARTICIPATION REQUIREMENTS MAY DIFFER FROM ONE GRANTEE TO ANOTHER. WITH THE EXCEPTION OF THE STATE CDBG PROGRAM, THE LOCAL GOVERNMENT GRANTEE ADMINISTERS THE CDBG PROGRAM AND DETERMINES WHICH LOCAL PROJECTS RECEIVE FUNDING. ELIGIBLE GRANTEES ARE AS FOLLOWS: PRINCIPAL CITIES OF METROPOLITAN STATISTICAL AREAS (MSAS); OTHER METROPOLITAN CITIES WITH POPULATIONS OF AT LEAST 50,000; QUALIFIED URBAN COUNTIES WITH POPULATIONS OF AT LEAST 200,000 (EXCLUDING THE POPULATION OF ENTITLED CITIES); STATES AND INSULAR AREAS. THE DISTRICT OF COLUMBIA IS FUNDED UNDER THE CDBG ENTITLEMENT PROGRAM. THE STATE OF HAWAII DOES NOT PARTICIPATE, AND HUD ALLOCATES THE STATE'S SHARE OF FUNDS TO THE THREE HAWAII NON-ENTITLED COUNTIES. THE STATES ADMINISTER CDBG FUNDS IN THE STATE CDBG PROGRAM. SINCE STATES ARE IN THE BEST POSITION TO KNOW, AND TO RESPOND TO, THE NEEDS OF LOCAL GOVERNMENTS, CONGRESS AMENDED THE HOUSING AND COMMUNITY DEVELOPMENT ACT OF 1974 (HCD ACT) IN 1981 TO GIVE EACH STATE THE OPPORTUNITY TO ADMINISTER CDBG FUNDS FOR NON-ENTITLEMENT AREAS.; SUBRECIPIENT ACTIVITIES: THE SUBRECIPIENT ACTIVITIES ARE UNKNOWN AT THE TIME OF AWARD.

ROLE OF HOMOLOGOUS RECOMBINATION IN THE REPLICATION STRESS RESPONSE - PROJECT SUMMARY/ABSTRACT PRECISE REPLICATION OF DNA IS REQUIRED TO MAINTAIN GENOME STABILITY. REPLICATION FORKS FACE MANY OBSTACLES FROM BOTH ENDOGENOUS AND EXOGENOUS SOURCES THAT RESULT IN FORK STALLING OR BREAKAGE THREATENING GENOME INTEGRITY. THE DOUBLE STRAND BREAK REPAIR PATHWAY, HOMOLOGOUS RECOMBINATION, HAS CRITICAL ROLES AT STALLED REPLICATION FORKS INDEPENDENT OF DOUBLE STRAND BREAK REPAIR. THE IMPORTANCE OF THIS PATHWAY IS HIGHLIGHTED BY PATIENTS WITH INHERITED CHROMOSOMAL INSTABILITY ORDERS AND CANCER PREDISPOSITION SYNDROMES. ALTHOUGH AN INTENSE AREA OF STUDY, THE MECHANISTIC ROLE OF RECOMBINATION PROTEINS AT REPLICATION FORKS IS STILL POORLY UNDERSTOOD. A COMPREHENSIVE UNDERSTANDING OF THE REPLICATION RESPONSE IS CRITICAL FOR THE UNDERSTANDING THE MOLECULAR MECHANISMS OF HUMAN DISEASE AND TO LEAD TO DEVELOPMENT OF NOVEL THERAPEUTICS FOR PATIENTS HARBORING DEFECTS IN REPLICATION RESPONSE GENES. THE LONG-TERM GOAL OF THE PI TO ELUCIDATE THE ROLES OF RECOMBINATION PROTEINS IN THE REPLICATION STRESS RESPONSE. HERE WE WILL ELUCIDATE THE ROLE OF RECOMBINATION PROTEINS AT HYDROXYUREA-STALLED REPLICATION FORKS IN TWO DISTINCT PROJECTS. IN PROJECT 1, WE USE A POWERFUL SEPARATION-OF-FUNCTION ALLELE OF THE CENTRAL RECOMBINATION ENZYME, RAD51, TO DETERMINE HOW RAD51 PROTECTS THE INTEGRITY OF THE REPLICATION FORK DURING UNCHALLENGED AND STRESSED CONDITIONS USING A COMBINATION OF GENETIC, MOLECULAR BIOLOGY AND PROTEOMIC APPROACHES. IN PROJECT 2, WE PROPOSE A SERIES OF EXPERIMENTS TO INVESTIGATE THE ROLE OF ADDITIONAL RECOMBINATION ACCESSORY FACTORS IN THE REPLICATION RESPONSE. PRELIMINARY DATA FROM OUR LAB HAS UNCOVERED A NOVEL ROLE FOR RECOMBINATION PROTEINS IN PROTECTING THE INTEGRITY OF STALLED REPLICATION FORKS. WE WILL TEST OUR CURRENT MODELS THROUGH MECHANISTIC DISSECTION OF THE REPLICATION STRESS RESPONSE PATHWAY USING GENETIC AND MOLECULAR APPROACHES. THE WORK PRESENTED HERE WILL LAY THE FOUNDATION FOR FUTURE STUDIES INVOLVING THE ELUCIDATION OF MOLECULAR MECHANISMS OF RECOMBINATION PROTEINS INVOLVED IN THE REPLICATION STRESS RESPONSE. THE COMPLETION OF THIS WORK WILL LEAD TO NOT ONLY A BETTER OF UNDERSTANDING OF THE ROLE RECOMBINATION PROTEINS PLAY AT STALLED REPLICATION FORKS, BUT WILL ALSO PROVIDE MOLECULAR INSIGHT INTO HOW DISRUPTION OF THIS PATHWAY RESULTS IN HUMAN DISEASE. A COMPLETE UNDERSTANDING OF THIS PATHWAY IS ESSENTIAL FOR DEVELOPMENT OF THERAPEUTICS FOR PATIENTS WITH INHERITED GENOME INSTABILITY DISORDERS AND CANCER THAT TARGET THE CELLULAR REPLICATION RESPONSE.

ORAL MICROBIOMES AND DENTAL CARIES IN A HUMAN IMMUNODEFICIENCY VIRUS INFECTED POPULATION

GRADUATE RESEARCH FELLOWSHIP PROGRAM (GRFP)

A PEER RECOVERY COACHING INTERVENTION FOR HOSPITALIZED ALCOHOL USE DISORDER PATIENTS - ALCOHOL USE DISORDER (AUD) IS THE THIRD LEADING CAUSE OF PREVENTABLE DEATHS IN U.S. AND ACCOUNTS FOR OVER 10% OF U.S. HOSPITAL ADMISSIONS. TREATMENT FOR THIS POPULATION OFTEN FAILS TO ADDRESS THE UNDERLYING CAUSE OF THE HOSPITALIZATION: THE AUD. PATIENTS HOSPITALIZED WITH ALCOHOL-RELATED MEDICAL COMPLICATIONS TEND TO HAVE HIGH-RISK FOR RECURRENCE OF ALCOHOL-RELATED MEDICAL PROBLEMS, HIGH RATES OF HOSPITAL READMISSIONS, AND POOR RECOVERY OUTCOMES. METHODS THAT PROMOTE LONG-TERM RECOVERY CARE ARE NEEDED. INPATIENT LINKAGE TO PEER RECOVERY COACHING MAY BRIDGE THIS GAP IN CARE BY PROVIDING A METHOD OF CONTINUED CARE FOR AUD RECOVERY THAT OFFERS FLEXIBILITY IN RECOVERY PATHWAYS, PEER MODELING OPPORTUNITIES, AND STRONG SOCIAL SUPPORT. PILOT STUDY RESULTS DEMONSTRATED THE FEASIBILITY OF INPATIENT LINKAGE TO PEER RECOVERY COACHING AND SHOWED EVIDENCE OF DECREASED ALCOHOL CONSUMPTION, INCREASED ENGAGEMENT IN TREATMENT AND RECOVERY SUPPORT PROGRAMS, AND DECREASED EMERGENCY DEPARTMENT VISITS. HOWEVER, PILOT STUDY SAMPLE SIZE, OUTCOMES, AND METHODS WERE LIMITED. THIS PROPOSAL SEEKS TO OVERCOME THESE LIMITATIONS AND BUILD ON THESE PRELIMINARY RESULTS BY: USING ECOLOGICAL MOMENTARY ASSESSMENTS, MEASURING RECOVERY USING THE NEW NIAAA DEFINITION, EXAMINING COST-EFFECTIVENESS, ASSESSING ALCOHOL CONSUMPTION USING AN ADDITIONAL OBJECTIVE MEASURE (BREATH ALCOHOL CONTENT LEVELS), AND EXAMINING SOCIAL SUPPORT AND SELF-EFFICACY AS POTENTIAL MECHANISMS OF EFFECTIVENESS. THIS PROPOSAL WILL RIGOROUSLY TEST THE EFFECTIVENESS OF AN INPATIENT PEER RECOVERY COACHING SERVICE CALLED THE RC-LINK PROGRAM ON RECOVERY OUTCOMES IN PATIENTS HOSPITALIZED WITH MEDICAL COMPLICATIONS FROM AUD. THE PROGRAM INVOLVES A BEDSIDE INTRODUCTION TO A PEER RECOVERY COACH DURING THE PATIENT’S HOSPITALIZATION PLUS CONTINUED, RECOVERY SUPPORT FOR SIX-MONTHS. THE RC-LINK PROGRAM PROVIDES STANDARDIZED PEER RECOVERY SERVICE THAT IS BOTH PERSONALIZED TO THE PATIENTS’ NEEDS AND GENERALIZED TO PROVIDE SOCIOEMOTIONAL, INSTRUMENTAL, AND INFORMATIONAL SOCIAL SUPPORT DURING EVERY PATIENT ENCOUNTER. AIM 1 WILL DETERMINE THE EFFECT OF THE RC-LINK PROGRAM ON FREQUENCY OF HEAVY DRINKING, BIOPSYCHOSOCIAL FUNCTIONING, AND REMISSION FROM AUD COMPARED TO CONTROLS. AIM 2 WILL EXAMINE HOW DAILY CHANGES IN PERCEIVED SOCIAL SUPPORT AND SELF-EFFICACY INFLUENCE ALCOHOL CONSUMPTION AND DETERMINE WHETHER SUCH ASSOCIATIONS DIFFER BETWEEN THE RC-LINK AND CONTROL GROUPS. AIM 3 WILL EXAMINE THE COST-EFFECTIVENESS OF THE RC-LINK PROGRAM; HOSPITAL UTILIZATION RATES WILL BE EXAMINED AS SECONDARY OUTCOMES. THESE AIMS WILL BE EVALUATED USING A TWO-ARM RANDOMIZED CONTROLLED TRIAL THAT COMPARES THE RC-LINK PROGRAM INTERVENTION TO A CONTROL GROUP THAT RECEIVES A BRIEF INTERVENTION AND CONNECTION TO A PEER RECOVERY COACH AFTER THE STUDY PERIOD. OUTCOMES WILL BE ASSESSED AT BASELINE, MONTHLY DURING THE 6-MONTH STUDY PERIOD, AND 6-MONTHS POST- INTERVENTION. THIS STUDY HAS POTENTIAL TO ADVANCE RECOVERY CARE FOR AUD BY PROVIDING A BETTER UNDERSTANDING OF HOW LONG-TERM, INPATIENT-INITIATED PEER RECOVERY COACHING INFLUENCES RECOVERY OUTCOMES OVER TIME IN THIS POPULATION.

EFRI-BSBA: MULTIFUNCTIONAL MATERIALS AND DEVICES FOR DISTRIBUTED ACTUATION AND SENSING

RESEARCH ADMINISTRATION CAPACITY HEIGHTENING IN SOUTH CAROLINA (REACH-SC) -SOCIETAL SHIFTS IN WORK, ALONG WITH THE AGING OF THE HIGHER EDUCATION WORKFORCE, ARE EXACERBATING ALREADY EXISTING CHALLENGES IN THE RESEARCH ENTERPRISE WORKFORCE. EMERGING RESEARCH INSTITUTIONS (ERIS) FREQUENTLY NEED ADDITIONAL RESEARCH ENTERPRISE INFRASTRUCTURE, INCLUDING RESEARCH STAFF. THE PURPOSE OF RESEARCH ADMINISTRATION CAPACITY HEIGHTENING IN SOUTH CAROLINA (REACH-SC) IS TO IDENTIFY WAYS TO GROW THE RESEARCH ADMINISTRATION WORKFORCE IN SC AND TO BUILD A NETWORK AMONG RESEARCH ADMINISTRATORS ACROSS SC THAT CAN ENHANCE HUMAN CAPITAL, INFORMATION AND KNOWLEDGE TRANSFER, AND SUPPORT FOR RESEARCH STAFF ACROSS SC. BY ADDRESSING THE UNIQUE CHALLENGES FACED BY SC AND LEVERAGING ITS STRENGTHS, REACH-SC CAN SERVE AS A CATALYST TO BOLSTER RESEARCH, INNOVATION, AND ACADEMIC PROWESS ACROSS THE STATE, AS WELL AS SERVE AS A MODEL FOR OTHER STATES. REACH-SC WILL ALSO EXPAND THE EXTANT RESEARCH ON GROWING THE RESEARCH ENTERPRISE WITHIN ERIS, CONTRIBUTING TO KNOWLEDGE ACROSS MULTIPLE DISCIPLINES (WORKFORCE DEVELOPMENT, HIGHER EDUCATION, RESEARCH ADMINISTRATION, AND INDUSTRIAL/ORGANIZATIONAL PSYCHOLOGY). REACH-SC FOCUSES ON TWO CRITICAL ELEMENTS OF ENHANCING THE RESEARCH ENVIRONMENT: (A) IDENTIFYING NEEDS OF ERIS TO ENSURE KNOWLEDGE NETWORK SUPPORT RESOURCES MEET THOSE NEEDS AND (B) CREATING NEW PATHWAYS TO IDENTIFY AND BUILD THE RESEARCH ENTERPRISE PIPELINE. THE PROJECT WILL CONDUCT A NEEDS ASSESSMENT WITH SC ERI RESEARCH ADMINISTRATORS AND STAFF FOCUSED ON IDENTIFICATION OF RESEARCH STRENGTHS, CHALLENGES, INFRASTRUCTURE GAPS, AND OPPORTUNITIES TO ENHANCE KNOWLEDGE TRANSMISSION AND MENTORING. IT WILL ESTABLISH THE SC STATEWIDE RESEARCH ENTERPRISE KNOWLEDGE AND MENTORING NETWORK (KNOWNET), WHICH WILL BE COMPRISED OF A MODERATED LISTSERV, MONTHLY ZOOM MEETINGS, A LINKEDIN GROUP, AND AN ANNUAL DAY-LONG CONFERENCE. KNOWNET WILL BRING TOGETHER RESEARCH ADMINISTRATION STAFF ACROSS SC TO ENHANCE KNOWLEDGE TRANSMISSION. TO CREATE NEW PATHWAYS TO EXPAND THE RESEARCH ENTERPRISE PIPELINE, REACH-SC WILL CONDUCT SKILLS MAPPING TO IDENTIFY OTHER OCCUPATIONS WHERE RESEARCH ADMINISTRATION SKILLS ARE PREVALENT. BY IDENTIFYING ADJACENT JOB TYPES THAT WILL YIELD PATHWAYS FOR IDENTIFYING INDIVIDUALS WHO COULD VIABLY TRANSITION INTO RESEARCH ADMINISTRATION POSITIONS, REACH-SC WILL HELP EXPAND THE RESEARCH ENTERPRISE PIPELINE. HUMAN RESOURCES (HR) COLLABORATORS WILL HELP TRANSLATE THE SKILLS MAPPING RESULTS INTO USABLE FORMATS EASILY UNDERSTOOD BY HR DEPARTMENTS AND RESEARCH ADMINISTRATION DIVISIONS. AN EXTERNAL ADVISORY BOARD WILL PROVIDE FEEDBACK AND GUIDANCE TO THE PROJECT. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE PLANNED FOR THIS AWARD.

CO-DREAM OER (COLLABORATIVE DEVELOPMENT OF ROBOTICS, MECHATRONICS, AND ADVANCED MANUFACTURING OPEN EDUCATION RESOURCES)

INTEGRATION OF TRANSMISSION AND DISTRIBUTION INFRASTRUCTURE FOR SEAMLESS RENEWABLE ENERGY PENETRATION. THE GOAL OF THIS PROJECT IS TO DEVELOP AN INTEGRATED TRANSMISSION AND DISTRIBUTION SYSTEM PLANNING TOOL AND ESTABLISH STRATEGIES TO ENHANCE THE TRANSMISSION AND DISTRIBUTION INFRASTRUCTURE'S EFFICIENCY, RELIABILITY, AND RESILIENCE.

COMMUNITY PROJECT FUNDING/CONGRESSIONALLY DIRECTED SPENDING - CONSTRUCTION - ABSTRACT PROJECT TITLE: WILLIAMSON HEALTH AND WELLNESS CENTER CONGRESSIONALLY DIRECTED SPENDING REQUEST – EQUIPMENT ONLY PROJECT APPLICANT NAME: WILLIAMSON HEALTH AND WELLNESS CENTER ADDRESS: 184 E. 2ND AVENUE, SUITE 210, WILLIAMSON, WV 25661 CONTACT NAME: DR. BECKETT, EXECUTIVE DIRECTOR CONTACT PHONE NUMBERS (VOICE, FAX): 304-236-5902 E-MAIL ADDRESS: CDBECKETT.DO@WILLIAMSONHEALTHWELLNESS.COM WEB SITE ADDRESS: WWW.WILLIAMSONHEALTHWELLNESS.COM CONGRESSIONAL DISTRICTS WITHIN YOUR SERVICE AREA: WV-003 WILLIAMSON MEMORIAL HOSPITAL, THE ONLY HOSPITAL IN MINGO COUNTY, WEST VIRGINIA, CLOSED MAY 16, 2020 AMIDST THE OUTBREAK OF THE COVID-19 GLOBAL PANDEMIC WHILE TRYING TO RETURN FROM BANKRUPTCY. WILLIAMSON HEALTH AND WELLNESS CENTER, A FEDERALLY QUALIFIED HEALTH CENTER, PURCHASED THE HOSPITAL IN MAY 2020 AND HAS BEEN WORKING DILIGENTLY SINCE TO DEVELOP AN INNOVATIVE NON-PROFIT RURAL HOSPITAL / FQHC MODEL THAT WILL SERVE AS A NATIONAL MODEL FOR SMALL TOWNS TRYING TO SAVE THEIR RURAL HOSPITALS, SECURE FUNDING, OVERSEE CAPITAL RENOVATIONS, AND RECRUIT NEW HEALTH CARE PARTNERS TO THE REGION. THE HOSPITAL WILL RE-OPEN AS WILLIAMSON MEMORIAL, INC., A NON-PROFIT ACUTE CARE HOSPITAL IN THE FALL 2022 THAT PROVIDES EMERGENCY SERVICES, LABORATORY, DIAGNOSTIC RADIOLOGY, IN-PATIENT HEALTH CARE, AND OUT-PATIENT SURGERY THAT WILL CREATE OVER 60 NEW AND RETAINED JOBS AND GENERATE 22,000 CLINICAL CARE VISITS WITHIN THE FIRST YEAR. WHWC IS REQUESTING $2 MILLION IN CONGRESSIONAL DIRECTED FUNDS AS AN EQUIPMENT-ONLY PROJECT TO SUPPORT A PORTION OF THE REMAINING $3.8 MILLION NEEDED TO SECURE NEW EQUIPMENT PURCHASES FOR THE HOSPITAL OPERATIONS. THESE COSTS REPRESENT A FRACTION OF THE INVESTMENT THAT WHWC HAS ALREADY MADE TO PURCHASE AND RENOVATE THE HOSPITAL FACILITY AS WELL AS PRIVATE AND FEDERAL INVESTMENT FOR CAPITAL RENOVATIONS, EQUIPMENT PURCHASES, LONG-TERM WORKING CAPITAL, AND START-UP COSTS FOR BOTH THE HOSPITAL AND VARIOUS PRIMARY CARE SERVICES AND SPEC IALTY CARE THAT WILL BE PROVIDED AT THE FACILITY. THE FIRST YEAR OF HOSPITAL OPERATIONS CARRIES THE GREATEST RISK AS THE HOSPITAL MUST BE ABLE TO COVER OPERATIONAL COSTS UNTIL THE NUMBER OF PATIENT VISITS GENERATES ENOUGH REVENUE TO MEET THE BREAK-EVEN POINT TO COVER EXPENSES. THE FEDERAL INFUSION OF CONGRESSIONAL DIRECTED FUNDS WILL HELP ASSURE THAT MINGO COUNTY RESIDENTS HAVE A LOCAL HOSPITAL THEY CAN COUNT ON, THAT WILL REMAIN FINANCIALLY SUSTAINABLE, AND ALLOW READY ACCESS TO EMERGENCY DEPARTMENT AND ACUTE CARE SERVICES INTO THE FUTURE.

** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** CHICKPEA (CICER ARIETINUM L.) IS A VERSATILE, CLIMATE-RESILIENT, AND SALT-TOLERANT PULSE CROP THAT WILL BECOME AN EXCELLENT NEW WINTER CASH CROP FOR SOUTHEASTERN ORGANIC PRODUCERS. PULSES PROVIDE SOIL HEALTH AND NITROGEN BENEFITS TO CROPPING SYSTEMS AND ARE A SIGNIFICANT SOURCE OF PLANT-BASED PROTEIN. CHICKPEAS CAN GROW AS A WINTER CASH CROP IN THE SOUTHEAST, FROM UPSTATE TO THE COAST, REPLACING ACREAGE LEFT FALLOW OR PLANTED WITH COVER CROPS. CULTIVARS BRED FOR CONVENTIONAL PRODUCTION ARE OFTEN UNSUITABLE FOR ORGANIC PRODUCTION, AND ORGANICALLY GROWN PULSE CROPS HAVE LOWER PROTEIN, MAKING ORGANIC PULSE PROTEINS MORE EXPENSIVE. INCREASING CROP PRODUCTION COSTS AND DECREASING COMMODITY PRICES MEAN ORGANIC GROWERS ARE EXPLORING NEW CROP OPTIONS. OUR LONG-TERM GOAL IS TO DEVELOP SHORT-SEASON CHICKPEA CULTIVARS FOR ORGANIC PRODUCTION WITH HIGHER PROTEIN QUALITY AND SUPERIOR MILLING PROPERTIES, SENSORY QUALITIES, AND ADAPTABILITY TO ORGANIC RICE/VEGETABLE SYSTEMS. THIS PROJECT IS BUILT ON OREI, GOOD FOOD INSTITUTE (GFI), AND SC DEPARTMENT OF AGRICULTURE-FUNDED PROJECTS TO ESTABLISH A BREEDING PIPELINE FOR THE PUBLIC RELEASE OF PROTEIN-BIOFORTIFIED ORGANIC CHICKPEA CULTIVARS FOR SOUTHEASTERN STATES. PROJECT OBJECTIVES ARE TO (1) DEVELOP PROTEIN-ENRICHED ORGANIC CHICKPEA VARIETIES USING ON-FARM FIELD TRAILS (PARTICIPATORY BREEDING), (2) COMBINE GENOMIC INFORMATION AND TRAIT DISCOVERY TO ENABLE THE BEST GENOTYPE-TO-PHENOTYPE MAPPING, AND (3) DEVELOP ON-FARM EDUCATIONAL AND EXTENSION ACTIVITIES USING THE GOING ORGANIC PLATFORM. THIS PROJECT IS ALIGNED WITH THE OREI GOALS TO (1) DEVELOP AND IMPROVE ORGANIC AGRICULTURE PRODUCTION, BREEDING, AND PROCESSING METHODS; (2) DETERMINE DESIRABLE TRAITS; (3) ON-FARM RESEARCH; AND (4) DEVELOP NEW AND IMPROVED SEED VARIETIES FOR ORGANIC AGRICULTURE.

MIIA - CLEMSON - CONST

IUSE/PFE:RED: CLEMSON UNIVERSITY: LEARNING TEAMS AND INNOVATION VENTURES FOR ADAPTABLE TRAINING IN ENGINEERING (CULTIVATE)

WILLIAMSON COUNTY GENERAL SESSIONS DUI COURT PROVIDES TREATMENT SERVICES TO INDIVIDUALS WHO, BY A LEGAL AND CLINICAL ASSESSMENT ARE IDENTIFIED TO BE A RISK TO SAFETY OF THE MIDDLE TENNESSEE COMMUNITY.

NANOPARTICLES AND NANOCAPSULES FOR GLIOMA TARGETING

NANOWIRED HYPOIMMUNOGENIC HPSC CARDIAC ORGANOIDS FOR HEART REPAIR - PROJECT SUMMARY: CARDIOVASCULAR DISEASE IS THE CAUSE OF 1 OUT OF EVERY 4 DEATHS IN THE UNITED STATES, WITH >800,000 PEOPLE SUFFERING FROM MYOCARDIAL INFARCTION EACH YEAR. HUMAN PLURIPOTENT STEM CELL DERIVED CARDIOMYOCYTES (HPSC-CMS) HOLD REMARKABLE PROMISE FOR TREATING INFARCTED HEARTS. TO ACCELERATE CLINICAL TRANSLATION OF HPSC-CMS, OUR LAB DEVELOPED NANOWIRED HUMAN CARDIAC ORGANOIDS COMPOSED OF HPSC-CMS, HUMAN CARDIAC FIBROBLASTS, ENDOTHELIAL CELLS, STROMAL CELLS, AND ELECTRICALLY CONDUCTIVE SILICON NANOWIRES (E- SINWS). OUR IN VIVO DATA SHOWED THAT THE ORGANOIDS WITH/WITHOUT E-SINWS (1E6: 1X106 CELLS/RAT) ROBUSTLY ENGRAFTED IN ISCHEMIA/REPERFUSION (I/R) INJURED ATHYMIC RAT HEARTS, WITH AN ENGRAFTMENT RATE OF ~30% 1-WEEK POST-IMPLANTATION. THE UNWIRED ORGANOIDS SHOWED COMPARABLE FUNCTIONAL RECOVERY (~39% FRACTIONAL SHORTENING (FS) RECOVERY) TO PREVIOUS STUDIES THAT INJECTED 10-FOLD GREATER DISSOCIATED HPSC-CMS/RAT (1E7 CELLS/RAT). FURTHER, THE NANOWIRED ORGANOIDS ILLUSTRATED SUPERIOR FUNCTIONAL RECOVERY (~69% FS RECOVERY). DESPITE THE PROGRESS, CURRENT CARDIAC ORGANOIDS ARE PREPARED THROUGH SPONTANEOUS ASSEMBLY OF HPSC-CMS AND PRIMARY CELLS, LEADING TO UNDEFINED HUMAN LEUKOCYTE ANTIGEN (HLA) EXPRESSIONS AND IMMUNE REJECTION AFTER IMPLANTATION. TO ALLEVIATE ALLOGENIC REJECTION, KEY GENES INVOLVED IN IMMUNE ACTIVATION/SUPPRESSION (E.G., B2M NECESSARY FOR HLA-A/B/C EXPRESSION, HLA-E/CD47) HAVE BEEN KNOCKED-OUT/IN TO HPSCS TO DERIVE HYPOIMMUNOGENIC HPSCS. NOTABLY, ISLETS DERIVED FROM HYPOIMMUNOGENIC HPSCS HAVE BEEN SHOWN TO EFFECTIVELY EVADE HOST IMMUNE SURVEILLANCE POST-IMPLANTATION AND FUNCTIONALLY RECOVER DIABETES IN A HUMANIZED MOUSE MODEL. UNLIKE HYPOIMMUNOGENIC HPSC ISLETS, THERE HAVE BEEN FEW STUDIES ON THE DERIVATION AND VALIDATION OF HYPOIMMUNOGENIC HPSC CARDIAC CELLS TO DATE. FURTHER, EFFECTS OF HYPOIMMUNOGENIC GENE EDITING ON THERAPEUTIC EFFICACIES OF HPSC CARDIAC CELLS HAVE NOT BEEN ASSESSED. IN ADDITION, THE EFFECTS OF E-SINWS ON THE HYPOIMMUNOGENIC CARDIAC CELLS HAS YET TO BE EXPLORED. THE GOAL OF THE PROPOSAL IS TO TEST IF HYPOIMMUNOGENIC GENE EDITING OF HPSCS WILL AFFECT THERAPEUTIC EFFICACIES OF NANOWIRED HPSC ISOGENIC CARDIAC ORGANOIDS. THE CENTRAL HYPOTHESES OF THE PROPOSAL ARE HYPOIMMUNOGENIC GENE EDITING DOES NOT SIGNIFICANTLY AFFECT THERAPEUTIC EFFICACY OF NANOWIRED CARDIAC ORGANOIDS. THE INNOVATIONS OF THE PROPOSAL INCLUDE, FOR THE FIRST TIME, WE WILL 1) DETERMINE THE EFFECTS OF HYPOIMMUNOGENIC GENE EDITING ON STRUCTURES/FUNCTIONS OF HPSC CARDIAC ORGANOIDS, AND 2) ILLUSTRATE THE SYNERGY BETWEEN BIOMATERIALS AND HYPOIMMUNE ON REGENERATIVE MEDICINE. ACCORDINGLY, WE WILL PURSUE 3 AIMS: 1) DETERMINE THE EFFECTS OF HYPOIMMUNOGENIC GENE EDITING ON HPSC CARDIAC CELLS, 2) DETERMINE THE EFFECTS OF E-SINWS ON HYPOIMMUNOGENIC HPSC ISOGENIC CARDIAC ORGANOIDS, AND 3) DETERMINE THERAPEUTIC EFFICACY AND HYPOIMMUNOGENICITY OF THE NANOWIRED HPSC CARDIAC ORGANOIDS OPTIMIZED IN AIM 2 IN VIVO. THE PROPOSED STUDIES WILL LAY DOWN THE FOUNDATION TO DEVELOP READILY AVAILABLE, “OFF-THE-SHELF” HPSC CARDIAC ORGANOIDS TO TREAT INFARCTED PATIENTS.

TREE AND WOOD PEST - ASIAN LONGHORNED BEETLE

NEW CONSENT BASED SITTING AWARD FOR CLEMSON UNIVERSITY

WHAT LEADS TO BETTER OUTCOMES IN INFORMAL STEM-BASED ENVIRONMENTAL EDUCATION PROGRAMS FOR YOUTH?

DEVELOPMENT OF A MULTIPLEXED ASSAY IN KINETOPLASTID PARASITES TO IDENTIFY PROBES FOR GLYCOLYSIS - PROJECT SUMMARY/ABSTRACT PARASITE INFECTION WITH MEMBERS OF THE CLASS KINETOPLASTEA, INCLUDING TRYPANOSOMA BRUCEI AND LEISHMANIA SPP., PLACES A TREMENDOUS BURDEN ON HUMAN HEALTH, WITH AN ESTIMATED ~1.4 MILLION CASES OF DISEASE RECORDED IN 2015 (WORLD HEALTH ORGANIZATION). DESPITE THE WIDESPREAD IMPACT OF THESE ORGANISMS, THERE REMAIN MAJOR GAPS IN OUR UNDERSTANDING OF FUNDAMENTAL PARASITE BIOLOGY. FOR EXAMPLE, IT IS APPRECIATED THAT GLUCOSE IS A CRITICAL METABOLITE THAT CAN ALSO SERVE TO REGULATE IMPORTANT DEVELOPMENTAL PATHWAYS IN THE PARASITES. HOWEVER, OUR UNDERSTANDING OF THESE AREAS, PARTICULARLY IN THE CONTEXT OF LIVING PARASITES, IS EXTREMELY LIMITED. WE PROPOSE TO ELUCIDATE KEY MECHANISTIC ASPECTS OF KINETOPLASTID GLUCOSE METABOLISM IN KINETOPLASTIDS USING A VALIDATED, YET UNPRECEDENTED, SCREENING ASSAY PLATFORM BASED ON LIVE PARASITES EXPRESSING PROTEIN SENSORS THAT MEASURE GLUCOSE UPTAKE, DISTRIBUTION, AND METABOLISM. WE WILL ADOPT THESE CELLS TO A NOVEL AND EFFECTIVE MULTIPLEXED HIGH-THROUGHPUT SCREENING ASSAY TO IDENTIFY SMALL MOLECULE PROBES THAT DISRUPT GLUCOSE UPTAKE, DISTRIBUTION AND METABOLISM IN LIVE PARASITES. THIS UNIQUE APPROACH WILL SIMULTANEOUSLY IDENTIFY INHIBITORS OF GLYCOLYSIS THAT POSSESS CHEMICAL PROPERTIES REQUIRED FOR DELIVERY TO THE CELLULAR TARGET. HITS FROM THE SCREENING OF A STRUCTURALLY DIVERSE 100,000 COMPOUND COLLECTION WILL BE VALIDATED BY RESYNTHESIS, RECONFIRMATION AND COUNTER- SCREENING. TARGET IDENTIFICATION, WHICH WILL BE FACILITATED BY MAPPING THE IMPACT OF THE INHIBITOR ON THE PATHWAY USING THE READ-OUT FROM THE ASSAY, WILL BE CONFIRMED USING REVERSE GENETIC AND PROTEOMIC APPROACHES. LAST, THE IDENTIFIED SMALL MOLECULE GLYCOLYTIC PROBE INHIBITORS WILL BE IMPROVED BY SAR AND THEIR ACTIVITY AGAINST PARASITES SCORED. EXPECTED OUTCOMES INCLUDE DEVELOPMENT OF A SCREENING STRATEGY THAT WILL BE APPLICABLE TO MANY TYPES OF CELLS, ALONG WITH THE IDENTIFICATION OF VALIDATED PROBES THAT DISSECT AN ESSENTIAL PARASITE METABOLIC PATHWAY.

DEVELOPMENT, VALIDATION, AND APPLICATION OF A CDS ONTOLOGY TO FACILITATE CDS RULES REUSE, MANAGEMENT, AND MAINTENANCE IN SIMULATED PRIMARY CARE SETTINGS.

SMITH LEVER 3B&C FUNDS