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Source: IRS Form 990 via ProPublica Nonprofit Explorer
Total Revenue
▼$257.8K
Total Contributions
$157.9K
Total Expenses
▼$213.1K
Total Assets
$398.6K
Total Liabilities
▼$3,075
Net Assets
$395.6K
Officer Compensation
→$79.6K
Other Salaries
$54.6K
Investment Income
▼$57
Fundraising
▼$0
Source: USAspending.gov · Searched by organization name
VA/DoD Awards
$4.5M
VA/DoD Award Count
2
Funding from the Department of Veterans Affairs and/or Department of Defense.
Total Federal Funding
$924.7M
Awards Found
150
| Awarding Agency | Description | Amount | Fiscal Year | Period |
|---|---|---|---|---|
| Department of Education | NEW JERSEY CHARTER SCHOOLS PROGRAM STATE ENTITIES GRANT (PROJECT CULTIVATE 38) | $63.2M | FY2021 | Oct 2020 – Sep 2025 |
| Department of Health and Human Services | HEALTH CENTER CLUSTER | $51.6M | FY2002 | Jan 2002 – Dec 2020 |
| Department of Health and Human Services | HEALTH CENTER CLUSTER | $45.5M | FY2002 | Jan 2002 – Dec 2027 |
| Department of Education | GREAT SCHOOLS COLORADO CSP PROJECT | $39.6M | FY2025 | Oct 2024 – Sep 2026 |
| Department of Education | NEW MEXICO CHARTER SCHOOLS PROGRAM GRANT PROJECT | $31.9M | FY2024 | Oct 2023 – Sep 2026 |
| Department of Education | PENNSYLVANIA CSP GRANT PROGRAM | $30M | FY2021 | Oct 2020 – Sep 2025 |
| Department of Education | GROWING HIGH QUALITY CHARTER SCHOOLS | $20M | FY2026 | Oct 2025 – Sep 2050 |
| Department of Education | WASHINGTON INNOVATION AND EXCELLENCE CSP GRANT PROGRAM | $19.7M | FY2020 | Oct 2019 – Sep 2024 |
| Department of Education | FUND FOR HIGH-POTENTIAL AND UNDERSERVED CHARTER SCHOOLS | $17.3M | FY2025 | Oct 2024 – Sep 2049 |
| Department of Education | PRESCHOOL DEVELOPMENT GRANTS - DEVELOPMENT | $16.3M | FY2015 | Jan 2015 – Dec 2018 |
| Department of Education | UTAH CHARTER SCHOOLS PROGRAM (UCSP) GRANT PROJECT | $15.6M | FY2025 | Oct 2024 – Sep 2026 |
| Department of Education | ILLINOIS IMPACT INITIATIVE: CREATING AND EXPANDING HIGH-QUALITY EDUCATIONAL OPPORTUNITIES FOR ILLINOIS’ MOST UNDERSERVED STUDENTS AND COMMUNITIES. | $14.9M | FY2023 | Oct 2022 – Sep 2026 |
| Department of Education | GREAT SCHOOLS FOR CONNECTICUT CSP PROEJCT | $14.7M | FY2023 | Oct 2022 – Sep 2026 |
| Agency for International Development | GH/HIDN/ID 936-3100 AAD | $13M | FY2012 | Sep 2012 – Sep 2021 |
| Department of Education | GAINING EARLY AWARENESS AND READINESS FOR UNDERGRADUATE PROGRAMS (GEAR UP PARTNERSHIP) | $12.3M | FY2014 | Sep 2014 – Jun 2022 |
| Department of Education | SECURING SUCCESS FOR ALL NEW YORK CITY CHILDREN | $12.1M | FY2023 | Apr 2023 – Mar 2027 |
| Department of Education | THE MARYLAND MOMENTUM PROJECT IS SUBMITTED TO CONTINUE THE GROWTH OF HIGH-QUALITY CHARTER SCHOOLS ACROSS THE STATE OF MARYLAND. | $10.2M | FY2025 | Oct 2024 – Sep 2026 |
| Department of Health and Human Services | ARRA - FACILITY INVESTMENT PROGRAM | $10M | FY2010 | Dec 2009 – Dec 2011 |
| Environmental Protection Agency | DESCRIPTION:THIS ACTION PROVIDES PARTIAL FUNDING IN THE AMOUNT OF $550,000 TO SUPPORT THE STARTEX-JACKSON-WELLFORD-DUNCAN WATER DISTRICT IN SOUTH CAROLINA TO IMPLEMENT ITS PROJECT TO REPLACE THE WATER TREATMENT PLANT'S 250,000 GALLONS CLEARWELL AND 5 MILLION GALLONS (MG) RECTANGULAR CLEARWELL WITH A NEW 7.5 MILLION GALLONS (MG) PRESTRESSED CONCRETE GROUND STORAGE TANK AS DIRECTED IN THE 2024 CONSOLIDATED APPROPRIATIONS ACT OR AS IDENTIFIED IN AN APPROVED TECHNICAL CORRECTION IF ONE HAS BEEN APPROVED FOR THIS PROJECT. ACTIVITIES:THE ACTIVITIES INCLUDE THE CONSTRUCTION OF A NEW 7.5 MILLION GALLONS (MG) TANK ADJACENT TO THE EXISTING 5 MILLION GALLONS (MG) CLEARWELL NEXT TO THE MIDDLE TYGER HIGH SERVICE PUMP STATION. THE OLD 250,000 GALLONS AND 5 MILLION GALLONS (MG) CLEARWELLS WILL BE ABANDONED IN PLACE AND EVENTUALLY DEMOLISHED UPON INITIATION OF CONSTRUCTION TO REPLACE THE CONVENTIONAL TREATMENT PLANT.SUBRECIPIENT:NO SUBAWARDS ARE INCLUDED IN THIS ASSISTANCE AGREEMENT.OUTCOMES:THE ANTICIPATED DELIVERABLE INCLUDES AN INCREASE TO THE OVERALL FINISHED WATER CAPACITY NEEDS FROM 10 MILLION GALLONS (MG) TO 12.5 MILLION GALLONS (MG) AT THE STARTEX-JACKSON-WELLFORD-DUNCAN WATER DISTRICT'S WATER TREATMENT PLANT. THE EXPECTED OUTCOMES INCLUDE BECOMING MORE EFFICIENT AND COST EFFECTIVE IN OVERALL TREATMENT AND WATER PRODUCTION OPERATIONS, AND THE CONTINUED PRODUCTION OF SAFE AND RELIABLE DRINKING WATER. THE INTENDED BENEFICIARIES INCLUDE THE RESIDENTS OF THE STARTEX-JACKSON-WELLFORD-DUNCAN WATER DISTRICT IN THE STATE OF SOUTH CAROLINA. | $10M | FY2025 | Oct 2024 – Dec 2026 |
| Department of Education | MISSION POSSIBLE: SECURING SUCCESS FOR NYC CHILDREN | $9.8M | FY2019 | Mar 2019 – Jun 2024 |
| Department of Health and Human Services | SUSTAINABLE SURVEILLANCE AT SCALE: DHIS2 AS A PLATFORM FOR IMPROVING GLOBAL CAPACITY TO PREVENT, DETECT & RESPOND TO PUBLIC HEALTH THREATS | $9.6M | FY2020 | Sep 2020 – Sep 2025 |
| Department of Education | TRIPLING ENROLLMENT IN WEST VIRGINIA'S CHARTER SECTOR IN 5 YEARS | $9M | FY2024 | Oct 2023 – Sep 2026 |
| Department of Education | CHARTER SCHOOLS MANAGEMENT ORGANIZATIONS | $8.7M | FY2011 | Oct 2010 – Sep 2015 |
| Agency for International Development | TO ACHIEVE ELIMINATION OF ONCHOCERCIASIS IN THE AMERICAS, THE UNITED STATES AGENCY FOR INTERNATIONAL DEVELOPMENT (USAID), BUREAU FOR GLOBAL HEALTH (GH), NEGLECTED TROPICAL DISEASES DIVISION PROPOSES A COOPERATIVE AGREEMENT (CA) FOR THE CONTROL AND ELIMINATION PROJECT FOR NEGLECTED TROPICAL DISEASES, ELEMENT 3, HEREBY ACHIEVE ONCHOCERCIASIS ELIMINATION IN THE AMERICAS (ACHIEVE OEA). THE PURPOSE OF ACHIEVE OEA IS TO ONCHOCERCIASIS IN THE LAST TWO FOCI IN THE AMERICAS. | $8.5M | FY2020 | Aug 2020 – Aug 2025 |
| Department of Education | CHARTER SCHOOLS MANAGEMENT ORGANIZATIONS | $8.1M | FY2012 | Oct 2011 – Sep 2017 |
| Department of Homeland Security | ASSISTANCE TO FIREFIGHTERS GRANT | $8.1M | FY2013 | Mar 2013 – Sep 2013 |
| Department of Education | INSPIRENOLA CONSORTIUM: REPLICATING HIGH QUALITY EDUCATION IN LOUISIANA | $8.1M | FY2019 | Mar 2019 – Oct 2024 |
| Department of Homeland Security | STAFFING FOR ADEQUATE FIRE AND EMERGENCY RESPONSE (SAFER) | $8M | FY2016 | Aug 2016 – Sep 2019 |
| Department of Housing and Urban Development | ECONOMIC DEVELOPMENT INITIATIVE, COMMUNITY PROJECT FUNDING, AND MISCELLANEOUS GRANTS | $7.2M | FY2023 | Feb 2023 – Aug 2030 |
| Department of Education | TEACHER INCENTIVE FUND | $7M | FY2015 | Oct 2014 – Sep 2017 |
| Department of Education | CHARTER SCHOOLS MANAGEMENT ORGANIZATIONS | $7M | FY2011 | Oct 2010 – Sep 2015 |
| Agency for International Development | ACCESS TO JUSTICE PROGRAM | $7M | FY2016 | Dec 2015 – Sep 2018 |
| Agency for International Development | THE PURPOSE OF THIS MOD IS TO:- - INCREMENTALLY FUND THE COOPERATIVE AGREEMENT IN THE AMOUNT OF $2,112,421.00 | $6.9M | FY2007 | Jan 2007 – Sep 2010 |
| Agency for International Development | AWARD TO CARTER CENTER FOR INDIGENOUS CONFLICT MANAGEMENT | $6.8M | FY2010 | Jan 2010 – Dec 2013 |
| Agency for International Development | NEW ELECTIONS OBSERVATION ACTIVITY | $6.5M | FY2023 | Nov 2022 – Dec 2024 |
| Department of Education | CHARTER SCHOOLS MANAGEMENT ORGANIZATIONS | $6.5M | FY2015 | Oct 2014 – Sep 2019 |
| Department of Education | CHARTER SCHOOLS MANAGEMENT ORGANIZATIONS | $6.1M | FY2016 | Oct 2015 – Sep 2020 |
| Department of Education | CHARTER SCHOOLS MANAGEMENT ORGANIZATIONS | $6M | FY2012 | Oct 2011 – Sep 2016 |
| Department of Education | SECURING SUCCESS FOR ALL NEW YORK CITY CHILDREN | $5.6M | FY2024 | Apr 2024 – Mar 2027 |
| Department of Transportation | APPLICATION PURPOSE: THE PURPOSE OF THIS GRANT IS TO CONSTRUCT AN INTERMODAL TRANSPORTATION CENTER.; ACTIVITIES PERFORMED: THIS PROJECT WILL FUND THE CONSTRUCTION OF AN INTERMODAL TRANSPORTATION BUILDING WITH THREE FULL STORIES ON APPROXIMATELY 8.67 ACRES AT ITS WATERFRONT. THE PROJECT SITE WILL INCLUDE A MIXED-USE INTERMODAL TRANSPORTATION CENTER CONSISTING OF A PASSENGER TERMINAL AND PORT AUTHORITY OFFICE SPACE. THE PROJECT SITE WILL ALSO CONNECT TO A 20-FOOT-WIDE ELEVATED PEDESTRIAN BOARDWALK FIXED PIER FLOATING DOCKS WAVE SCREEN AND HANDICAP ACCESS RAMP; EXPECTED OUTCOMES: THE CARTERET FERRY TERMINAL PROJECT IS CENTRAL TO REVITALIZING THE BOROUGHS WATERFRONT PROVIDING AFFORDABLE TRANSPORTATION AND CREATING ECONOMIC OPPORTUNITIES.; INTENDED BENEFICIARIES: CENTRAL NEW JERSEY RESIDENTS.; SUBRECIPIENT ACTIVITIES: NONE | $5.6M | FY2025 | Sep 2025 – Jun 2028 |
| Department of Education | REPLICATING ZETA'S HIGH-QUALITY CHARTER SCHOOLS | $5.5M | FY2025 | Apr 2025 – Mar 2027 |
| Department of Health and Human Services | FAMILY PLANNING PROJECT INCLUDING HIV INTEGRATION TO FAMILY PLANNING SERVICES | $5.3M | FY2007 | Jan 2007 – Sep 2012 |
| Department of Education | CHARTER SCHOOLS - CHARTER SCHOOLS NATIONAL ACTIVITIES COMPETITION | $5.3M | FY2007 | Oct 2006 – Sep 2010 |
| Department of Agriculture | FOOD FOR PROGRESS; TO PROVIDE AG COMODTYS TO DEVELOPING COUNTRIES & EMERGING DEMOCRACIES TO INTRODUCE & EXPAND FREE ENTERPRISE IN THE AG SECTOR | $5.3M | FY2009 | Jun 2009 – Jun 2009 |
| Department of Agriculture | GRANT FOR PROD OF ADV BIOFUEL | $4.8M | FY2011 | Sep 2011 – Sep 2011 |
| Department of Agriculture | WASTE DISPOSAL GRANTS - 09/10 STIMULUS | $4.8M | FY2009 | Jul 2009 – Jul 2009 |
| Department of Health and Human Services | EARLY HEAD START | $4.7M | FY2021 | Jan 2021 – Dec 2025 |
| Department of Education | CITIZENS OF THE WORLD CHARTER SCHOOLS - LOS ANGELES GROWTH PLAN | $4.5M | FY2020 | Apr 2020 – Mar 2025 |
| Department of Education | MISSISSIPPI CHARTER SCHOOL AUTHORIZER BOARD 2017 CSP GRANT | $4.3M | FY2018 | Oct 2017 – Sep 2023 |
| Department of Education | CHARTER SCHOOLS - CHARTER SCHOOLS NATIONAL ACTIVITIES COMPETITION | $4.2M | FY2007 | Oct 2006 – Dec 2010 |
| Department of Education | CHARTER SCHOOLS MANAGEMENT ORGANIZATIONS | $4.1M | FY2017 | Oct 2016 – Sep 2022 |
| Agency for International Development | THE ABOVE GRANT ISSUED UNDER APS M-OAA-GRO-LMA-08-279 TO CONDUCT INTERNATIONAL OBSERVATION ACTIVITIES FROM THE ESTABLISHMENT OF THE COMPREHENSIVE PEA | $4.1M | FY2009 | Jan 2009 – Jul 2011 |
| Department of Health and Human Services | AMERICAN RESCUE PLAN ACT FUNDING FOR HEALTH CENTERS | $4.1M | FY2021 | Apr 2021 – Mar 2023 |
| Department of Health and Human Services | HEAD START | $4M | FY2020 | Jul 2020 – Jun 2025 |
| Department of Housing and Urban Development | PURPOSE: ECONOMIC DEVELOPMENT INITIATIVE, COMMUNITY PROJECT FUNDING/CONGRESSIONAL DIRECTED SPENDING AWARDS ARE AUTHORIZED UNDER THE CONSOLIDATED APPROPRIATIONS ACT, 2022 PUBLIC LAW 117-328 AND THE EXPLANATORY STATEMENT FOR DIVISION L OF THAT ACT. PROJECTS SELECTED FOR COMMUNITY PROJECT FUNDING/CONGRESSIONAL DIRECTED SPENDING ARE LISTED IN THE JOINT EXPLANATORY STATEMENT (JES) THAT ACCOMPANIES A SPECIFIC FISCAL YEAR’S APPROPRIATIONS ACT OR CONGRESSIONAL RECORD. THE JES LISTS PROJECT, RECIPIENT, STATE, AMOUNT AND CONGRESSIONAL SPONSOR.; ACTIVITIES TO BE PERFORMED: ECONOMIC DEVELOPMENT INITIATIVE, COMMUNITY PROJECT FUNDING/CONGRESSIONALLY DIRECTED SPENDING AWARD PROJECTS INCLUDE A WIDE VARIETY OF ACTIVITIES THAT RESULT IN ECONOMIC DEVELOPMENT OR COMMUNITY DEVELOPMENT OUTCOMES. HUD WILL NOT KNOW THE FULL SCOPE OF THE PROJECT UNTIL THE RECIPIENT SUBMITS THE REQUIRED PROJECT NARRATIVE AND CONFIRMS ALIGNMENT WITH THE LANGUAGE AS PROVIDED IN THE CONGRESSIONAL RECORD. TO FIND THE DETAILS OF THE GRANT AWARD AS WRITTEN WITHIN THE CONGRESSIONAL RECORD USE THE FOLLOWING LINK AND PATH SELECTIONS TO GET TO THE DESCRIPTION OF THE ECONOMIC DEVELOPMENT INITIATIVE, COMMUNITY PROJECT FUNDING GRANTS HTTPS://WWW.HUD.GOV/PROGRAM_OFFICES/COMM_PLANNING/EDI-GRANTS, SELECT THE FISCAL YEAR OF INTEREST, SCROLL DOWN TO PROGRAM LAWS AND REGULATIONS, UNDER FISCAL YEAR 20XX CONSOLIDATED APPROPRIATIONS ACT, 20XX: CONGRESSIONAL RECORD (JOINT EXPLANATORY STATEMENT).; EXPECTED OUTCOMES: COMPLETION OF THE PROJECT AS DESCRIBED IN THE JOINT EXPLANATORY STATEMENT (JES) PROJECT DESCRIPTION AND SUBSEQUENT APPROVED PROJECT NARRATIVE.; INTENDED BENEFICIARIES: THE PROJECT BENEFICIARIES ARE THE INDIVIDUALS AND/OR ORGANIZATIONS THAT ARE AWARDED GRANT FUNDS OR SERVED BY THE ENTITIES THAT ARE AWARDED GRANT FUNDS AS IDENTIFIED IN THE JES RECIPIENT OR PROJECT DESCRIPTION SECTIONS.; SUBRECIPIENT ACTIVITIES: THE SUBRECIPIENT ACTIVITIES ARE UNKNOWN AT THE TIME OF AWARD. | $4M | FY2024 | Aug 2024 – Aug 2032 |
| Agency for International Development | CARTER CENTER ELECTION PROGRAM | $4M | FY2011 | Apr 2011 – Dec 2013 |
| Department of Education | ALL TRIBES CAREER TECHNICAL EDUCATION PROGRAM HOME | $4M | FY2024 | Oct 2023 – Oct 2026 |
| Department of Justice | WAYNE COUNTY PROSECUTOR'S OPERATION RELENTLESS PURSUIT | $3.9M | FY2020 | Apr 2020 – Mar 2023 |
| Department of Health and Human Services | FAMILY PLANNING SERVICES GRANT | $3.8M | FY2012 | Dec 2011 – Mar 2015 |
| Department of Transportation | IMPROVE EXISTING AIRPORT | $3.8M | FY2016 | Sep 2016 – Sep 2020 |
| Department of Health and Human Services | TITLE X FAMILY PLANNING PROGRAM NON-COMPETING APPLICATION 2017-2018 | $3.8M | FY2015 | Apr 2015 – Aug 2018 |
| Department of Education | CHARTER SCHOOLS MANAGEMENT ORGANIZATIONS | $3.7M | FY2016 | Oct 2015 – Dec 2019 |
| Department of Health and Human Services | HEAD START | $3.5M | FY2015 | Jul 2015 – Jun 2020 |
| Department of Education | HIGHER EDUCATION RELIEF FUNDS FOR STUDENTS | $3.5M | FY2021 | Feb 2021 – Feb 2022 |
| Agency for International Development | THE CARTER CENTER MONITORING NEPAL'S PEACE AND CONSTITUTION DRAFTING | $3.5M | FY2009 | Aug 2009 – Jun 2014 |
| Department of Education | VOLUNTARY SCHOOL CHOICE | $3.5M | FY2010 | Aug 2010 – Jul 2012 |
| Department of Education | HIGHER EDUCATION RELIEF FUNDS FOR STUDENTS | $3.4M | FY2020 | May 2020 – May 2021 |
| Department of Education | HIGHER EDUCATION RELIEF FUNDS FOR INSTITUTION | $3.4M | FY2020 | May 2020 – May 2021 |
| Environmental Protection Agency | DESCRIPTION:THIS AGREEMENT PROVIDES FUNDING TO ROYAL OAK CHARTER TOWNSHIP TO IMPLEMENT ITS PROJECT TO REPLACE AGING WATER MAINS AS DIRECTED IN THE 2022, 2023, AND 2024 CONSOLIDATED APPROPRIATIONS ACTS OR AS IDENTIFIED IN AN APPROVED TECHNICAL CORRECTION IF ONE HAS BEEN APPROVED FOR THIS PROJECT. THIS PROJECT USES FUNDING APPROPRIATED FROM FY22, FY23, AND FY24.ACTIVITIES:THE ACTIVITIES TO BE PERFORMED ARE THE REPLACEMENT OF UNDERSIZED AND LEAD SERVICE LINES AND MAINS IN ROYAL OAK CHARTER TOWNSHIP.SUBRECIPIENT:NO SUBAWARDS ARE INCLUDED IN THIS ASSISTANCE AGREEMENT.OUTCOMES:THE ANTICIPATED DELIVERABLES ARE IMPROVED WATER DELIVERY, WHICH ARE EXPECTED TO LEAD TO MORE RELIABLE WATER SERVICE TO THE PEOPLE OF ROYAL OAK CHARTER TOWNSHIP. | $3.4M | FY2024 | Sep 2024 – May 2026 |
| Department of Commerce | DS-19 AIRPORT HANGAR | $3.3M | — | — – — |
| Department of Education | CHARTER SCHOOLS - CHARTER SCHOOLS NATIONAL ACTIVITIES COMPETITION | $3.3M | FY2007 | Oct 2006 – Sep 2010 |
| Department of Homeland Security | STAFFING FOR ADEQUATE FIRE AND EMERGENCY RESPONSE (SAFER) | $3.2M | FY2022 | Feb 2022 – Feb 2025 |
| Department of Education | INSTITUTIONAL PORTION COVID-19 EMERGENCY RELIEF GRANT | $3.1M | FY2020 | May 2020 – May 2022 |
| Department of Education | IMPACT AID PROGRAM, TITLE VII, SECTION 7003 | $3.1M | FY2026 | Oct 2025 – Sep 2031 |
| Department of Education | NYC IN BALANCE | $3.1M | FY2023 | Apr 2023 – Dec 2026 |
| Environmental Protection Agency | DESCRIPTION:THIS AGREEMENT PROVIDES FUNDING TO BERLIN CHARTER TOWNSHIP TO IMPLEMENT ITS WASTEWATER DISCHARGE LINE PROJECT AS DIRECTED IN THE 2023 CONSOLIDATED APPROPRIATIONS ACT OR AS IDENTIFIED IN AN APPROVED TECHNICAL CORRECTION IF ONE HAS BEEN APPROVED FOR THIS PROJECT. ACTIVITIES:THE ACTIVITIES TO BE PERFORMED INCLUDE THE EXECUTION AND IMPLEMENTATION OF A WASTEWATER INFRASTRUCTURE CONSTRUCTION PROJECT. WORKPLAN ACTIVITIES CONSIST OF: CONSTRUCTION OF APPROXIMATELY 12,000 LINEAL FEET OF FORCE MAIN AND APPURTENANCES, ADDITION OF ONE NEW EFFLUENT PUMP, AND RESTORATION OF AREAS DISTURBED BY CONSTRUCTION. SUBRECIPIENT:NO SUBAWARDS ARE INCLUDED IN THIS ASSISTANCE AGREEMENT.OUTCOMES:THE ANTICIPATED DELIVERABLES INCLUDE INSTALLATION OF APPROXIMATELY 12,000 LINEAL FEET OF FORCE MAIN AND ONE NEW EFFLUENT PUMP. THE EXPECTED OUTCOMES INCLUDE PROTECTING WATER QUALITY IN LAKE ERIE BY PREVENTING FAILURE OF THE FORCE MAIN, REPLACING AGING INFRASTRUCTURE, AND MAINTAINING AFFORDABLE SEWER RATES. THE INTENDED BENEFICIARIES INCLUDE RESIDENTS OF BERLIN CHARTER TOWNSHIP. | $3M | FY2025 | Sep 2025 – Sep 2026 |
| Department of Education | NEW YORK CITY CHARTER SCHOOL CONSORTIUM FOR SCHOOL CLIMATE TRANSFORMATION | $3M | FY2020 | Oct 2019 – Sep 2024 |
| Department of Housing and Urban Development | ECONOMIC DEVELOPMENT INITIATIVE, COMMUNITY PROJECT FUNDING, AND MISCELLANEOUS GRANTS | $3M | FY2023 | Feb 2023 – Aug 2031 |
| Department of Education | INVESTING IN INNOVATION - DEVELOPMENT GRANTS | $3M | FY2015 | Jan 2015 – Dec 2019 |
| Department of Health and Human Services | MANUFACTURING RNA-BASED CAR T CELLS TO COMBAT AUTOANTIBODY-ASSOCIATED AUTOIMMUNE DISORDERS (AAAD) - AUTOANTIBODY-ASSOCIATED AUTOIMMUNE DISEASES (AAADS) ARE DISORDERS IN WHICH DYSFUNCTIONAL PLASMA CELLS (PCS) SECRETE AUTOANTIBODIES THAT ATTACK HEALTHY TISSUE. MANY AAADS ATTACK THE NERVOUS SYSTEM, SUCH AS MYASTHENIA GRAVIS (MG), NEUROMYELITIS OPTICA, CHRONIC INFLAMMATORY DEMYELINATING POLYNEUROPATHY, LAMBERT- EATON SYNDROME, AND NECROTIZING AUTOIMMUNE MYOPATHY. THIS R44 (CLINICAL TRIAL NOT ALLOWED) WILL SUPPORT MANUFACTURING OF A NEW RNA-BASED CELL THERAPY FOR NEUROLOGICAL AAADS, AND ANALYSIS OF BIOMARKERS FROM PATIENTS WHO RECEIVED THE THERAPY. CHIMERIC ANTIGEN RECEPTOR T CELL (CAR-T) THERAPY ELIMINATES PATHOGENIC CELLS, SUCH AS PCS, BY EXPRESSING ENGINEERED CHIMERIC ANTIGEN RECEPTORS (CAR) IN T CELLS ISOLATED FROM A PATIENT; THE T CELLS ARE THEN REINFUSED TO KILL THE CAR’S TARGET. ALL APPROVED CAR T DRUGS RELY ON GENE TRANSFER BY DNA, WHICH PERMANENTLY MODIFIES THE GENOME. THIS POSES SEVERAL PROBLEMS. DNA-MODIFIED CAR-T CELLS MULTIPLY EXPONENTIALLY BECAUSE CAR DNA REPLICATES; THIS CAN CAUSE LIFE-THREATENING INFLAMMATION CALLED CYTOKINE RELEASE SYNDROME (CRS). THESE CAR-T CELLS ALSO REQUIRE PRE-TREATMENT CHEMOTHERAPY TO CREATE A NICHE FOR CELL PROLIFERATION. DNA-MODIFIED CAR-T CELLS ARE EXPENSIVE TO MAKE AND USE CLINICALLY, BECAUSE FREQUENT ADVERSE EVENTS REQUIRE CLOSE PATIENT MONITORING. THESE HURDLES HAVE LIMITED CAR-T THERAPY ONLY TO ADVANCED CANCERS. CARTESIAN THERAPEUTICS HAS DESIGNED A NEW APPROACH THAT REPLACES DNA WITH RNA TO ACHIEVE TRANSIENT, TUNABLE CAR EXPRESSION (RCAR-T). UNLIKE DNA-MODIFIED CAR T CELLS, CAR-ENCODING RNA CANNOT REPLICATE AND DECAYS IN PREDICTABLE FASHION. THUS, THE PATIENT’S EXPOSURE TO RCAR-T CELLS IS DETERMINED BY CELL DOSE. THIS AVOIDS CRS AND ELIMINATES LYMPHODEPLETING CHEMOTHERAPY. THESE ADVANCES CREATE A VERSATILE, CLINICALLY-VALIDATED MEANS TO TREAT NEUROLOGICAL AAADS. WE HAVE DEVELOPED AN RCAR-T THAT TARGETS B CELL MATURATION ANTIGEN (BCMA). THIS MARKER IS EXPRESSED ON PCS – CELLS THAT PRODUCE AUTOANTIBODIES IN AAADS. THIS THERAPY – “DESCARTES-08” – TRANSIENTLY EXPRESSES ANTI-BCMA CAR TO TARGET BCMA+ PCS AFTER INFUSION. MG IS AN AAAD IN WHICH BCMA+ PCS SECRETE AUTOANTIBODIES THAT ATTACK THE NEUROMUSCULAR JUNCTION, CAUSING SEVERE MUSCLE WEAKNESS. IN THE FIRST SUCCESSFUL PHASE 2A TRIAL OF A CELL THERAPY TO TREAT AUTOIMMUNITY (NCT04146051), DESCARTES-08 CONFERRED POTENT, SAFE, AND LONG-LASTING IMPROVEMENT IN MG PATIENTS FOR 12 MONTHS OR MORE, EVEN THOUGH TREATMENT WAS ONLY 6-WEEKS (LANCET NEUROLOGY 2023). THESE BENEFITS WERE ACHIEVED WITHOUT THE TOXICITY, INPATIENT STAYS, OR LYMPHODEPLETION NEEDED IN DNA-BASED CAR-TS. HERE WE PROPOSE KEY STEPS TO DEVELOP RCAR-T AS A NEW CELL THERAPY OPTION TO TREAT NEUROLOGICAL AAADS. THE AIMS ARE I) MANUFACTURE DESCARTES-08 PRODUCT LOTS TO COMPLETE THE PHASE 2 MG CLINICAL TRIAL, II) IDENTIFY CLINICAL CORRELATES IN PATIENT SAMPLES FROM ONGOING RANDOMIZED PLACEBO-CONTROLLED TRIAL (RCT) AND III) MANUFACTURE DESCARTES-08 LOTS FOR EXPANDED ACCESS AND BASKET TRIAL PATIENTS WITH OTHER NEUROLOGICAL AAADS. COMPLETING THESE AIMS WILL POSITION DESCARTES-08 TO BECOME THE FIRST COMMERCIAL RCAR-T PRODUCT FOR A VARIETY OF AAADS. | $3M | FY2024 | Jun 2024 – May 2026 |
| Department of Health and Human Services | ONCHOCERCIASIS ELIMINATION PROGRAM FOR THE AMERICAS | $3M | FY2012 | Apr 2012 – Mar 2017 |
| Department of Health and Human Services | A RANDOMIZED DOUBLE-BLIND PLACEBO CONTROLLED PHASE 1 SAD STUDY IN MALE AND FEMALE HEALTHY VOLUNTEERS TO ASSESS SAFETY, PHARMACOKINETICS, AND TRANSIENT BIOMARKER CHANGES BY THE ABCA1 AGONIST CS6253 - PROJECT SUMMARY LATE-ONSET OR SPORADIC ALZHEIMER'S DISEASE (AD) CONSTITUTE 95 PERCENT OF ALL AD AND APOE4 IS THE DOMINATING GENETIC RISK FACTOR. WHILE THERE ARE THREE MAJOR APOE ALLELIC VARIANTS (APOE2, APOE3, AND APOE4), APOE4 CARRIERS HAVE AN INCREASED RISK OF DEVELOPING AD, AND UP TO 66% OF INDIVIDUALS WITH AD-TYPE DEMENTIA CASES AND 64% WITH MILD COGNITIVE IMPAIRMENT, ALSO CARRY THE APOE4 ALLELE. THERE ARE CURRENTLY NO TREATMENTS FOR APOE4 DRIVEN AD OR OTHER DEMENTIAS. ARTERY THERAPEUTICS, INC. (ARTERY; ATI) HAS DEVELOPED A NOVEL CHEMICAL ENTITY FOR THE TREATMENT OF APOE4 DRIVEN DEMENTIAS, INCLUDING AD. CS6253 IS A 2ND-GENERATION SELECTIVE ATP- BINDING-CASSETTE A1 (ABCA1) TRANSPORTER AGONIST PEPTIDE DERIVED FROM THE C-TERMINAL OF APOE. CS6253 IS A SAFE, POTENT, AND DRUGGABLE ABCA1 AGONIST. ATI'S PRECLINICAL DATA IN CELL SYSTEMS AND TWO DIFFERENT APOE4 TRANSGENIC MICE MODELS HAVE DEMONSTRATED THAT CS6253 ENGAGES ABCA1 AS A TARGET, IMPROVES APOE LIPIDATION, PREVENTS HIPPOCAMPAL AMYLOID-SS (ASS) PATHOPHYSIOLOGY, AND IMPROVES COGNITION. IN IND-ENABLING STUDIES, WHICH SHOWED EXCELLENT SAFETY AND PHARMACOKINETICS PROPERTIES, IT WAS DEMONSTRATED THAT IN PRIMATES, CS6253 TREATMENT OVER 9 DAYS SHOWED PRONOUNCED DOSE-RESPONSE REDUCTIONS IN CEREBROSPINAL FLUID (CSF) CONCENTRATIONS OF ASS42, ASS40, AND APP, AND OTHER MARKERS. THESE DATA STRONGLY SUPPORT AND EXTEND OUR EFFICACY RESULTS IN MICE PHARMACOLOGY MODELS AND ARE PREDICTIVE OF EFFICACY IN HUMANS. THUS, WITH THIS SBIR PROPOSAL, WE WILL ADVANCE CS6253 INTO EARLY CLINICAL TRIALS. IN AIM 1, ATI WILL ESTABLISH QUALIFYING METHODS FOR GMP DRUG PRODUCT AND STABILITY AT -20C FOR COFA AND RELEASE FOR PHASE 1 CLINICAL TRIAL MATERIAL. GMP DRUG PRODUCT WILL COMPLETE THE CMC SECTION (GMP DRUG SUBSTANCE IS ALREADY PRODUCED) WHICH WILL BE ADDED TO THE CLINICAL AND NONCLINICAL SECTIONS OF THE IND, FOR SUBMITTING THE IND. THE AIM 1 MILESTONE IS TO OPEN THE IND, I.E. RECEIVE FDA BUY-IN FOR INITIATING THE CS6253 PHASE 1 TRIAL. WE ARE CONFIDENT OF A SUCCESSFUL IND BASED ON THE AUGUST 2020 PRE-IND MEETING WITH FDA WHERE CONSENSUS WAS REACHED REGARDING KEY ASPECTS OF THE PROGRAM INCLUDING CMC, NONCLINICAL AND THE INITIAL CLINICAL TRIALS. IN AIM 2, WE WILL PERFORM A RANDOMIZED DOUBLE BLIND PLACEBO CONTROLLED SINGLE ASCENDING DOSE TRIAL IN HEALTHY 50-70 Y.O. MEN AND WOMEN (N=8/COHORT, 6 ACTIVE: 2 PLACEBO, TOTAL N=32) WHO WILL BE CHARACTERIZED BUT NOT STRATIFIED FOR APOE ISOFORM. PARTICIPANTS WILL RECEIVE A SINGLE INTRAVENOUS (IV) ADMINISTRATION OF CS6253 AT 4 SINGLE ASCENDING DOSES. OUR AIM 2 MILESTONE IS TO ESTABLISH SAFETY AND PHARMACOKINETICS (PLASMA AND CSF) IN HUMANS AND A SAFE STARTING DOSE FOR THE MULTIPLE ASCENDING DOSE (MAD) STUDY. WE WILL ALSO EXPLORE TRANSIENT EFFECTS ON LIPIDS AND AD BIOMARKERS BY CS6253 INCLUDING TEMPORAL PLASMA – CSF DYNAMICS OF APOLIPOPROTEINS AND AD MARKERS. THIS PROJECT WILL DETERMINE CS6253'S PHARMACOKINETICS (PLASMA AND CSF) AND SINGLE DOSE SAFETY, AND PREPARE FOR PHASE 1 MAD STUDIES OF UP TO 30 DAYS. OVERALL, CS6253 IS AN EXTREMELY PROMISING ABCA1 TARGETING NOVEL THERAPY WITH POTENTIAL TO ADDRESS APOE4 ASSOCIATED DEMENTIA INCLUDING AD. | $3M | FY2021 | Sep 2021 – Dec 2024 |
| Department of Education | EXPANDING SUCCESS FOR NYC CHILDREN | $3M | FY2018 | Oct 2017 – Sep 2021 |
| Department of State | INCREASE PUBLIC CONFIDENCE IN THE FORMAL JUSTICE SYSTEM THROUGH OUTREACH | $2.9M | FY2018 | Apr 2018 – Apr 2023 |
| Department of Education | EARLY READING FIRST | $2.9M | FY2008 | Sep 2008 – Aug 2012 |
| Department of Education | ESCUELA DE ARTES PLASTICAS Y DISENO USDE TITLE V | $2.9M | FY2021 | Oct 2020 – Sep 2025 |
| Department of Health and Human Services | CS6253 DEVELOPMENT FOR THE TREATMENT OF APOE4 DRIVEN DEMENTIA INCLUDINGALZHEIMER'S DISEASE | $2.9M | FY2019 | Jun 2019 – Dec 2021 |
| Department of Energy | TAS::89 0321::TAS NEW CONGRESSIONALLY DIRECTED GRANT TO THE CHARTER TOWNSHIP OF YPSILANTI FOR A PROJECT ENTITLED "ENERGY EFFICIENCY UPGRADES FOR THE | $2.9M | FY2010 | Aug 2010 – Oct 2011 |
| Department of Education | THE NEW YORK CITY CHARTER SCHOOL CONSORTIUM TO .... | $2.8M | FY2023 | Jan 2023 – Dec 2026 |
| Department of Education | GREAT OAKS LEGACY CHARTER SCHOOL: EXPANDING HIGH-QUALITY SEATS IN NEWARK, NEW JERSEY | $2.8M | FY2020 | Apr 2020 – Mar 2025 |
| Department of Education | SCHOOL CLIMATE TRANSFORMATION GRANTS TO LEAS | $2.7M | FY2015 | Oct 2014 – Sep 2019 |
| Department of Education | IMPACT AID PROGRAM, TITLE VII, SECTION 7003 | $2.7M | — | — – Sep 2030 |
| Department of Energy | SOLAR3.0 A NATIONAL PLATFORM FOR PROCESS INNOVATION | $2.7M | FY2011 | Sep 2011 – Jul 2013 |
| Department of Education | TRI-STATE ALLIANCE FOR IMPROVING DISTRICT-LED CHARTER AUTHORIZING | $2.7M | FY2019 | Oct 2018 – Sep 2022 |
| Agency for International Development | ADVANCING WOMEN'S RIGHT OF ACCESS TO INFORMATION IN BANGLADESH (AWRTI) ACTIVITY. | $2.6M | FY2023 | Apr 2023 – Mar 2028 |
| Department of Health and Human Services | CS6253 SEQUENTIAL SUBCUTANEOUS PHARMACOKINETIC STUDY FOLLOWED BY PHASE 2A PLACEBO-CONTROLLED TRIAL WITH THREE FIXED DOSES IN APOE4 MCI AND AD PATIENTS TO ASSESS SAFETY, PK, AND BIOMARKER EFFECTS - PROJECT SUMMARY ARTERY THERAPEUTICS, INC. (ATI) IS DEVELOPING CS6253, A HIGHLY DIFFERENTIATED, CHOLESTEROL-TRANSPORT FOCUSED TREATMENT FOR THE INDICATION OF HEREDITARY APOE4-ASSOCIATED DEMENTIA INCLUDING MCI-AD, TARGETING THE ATP- BINDING-CASSETTE-TRANSPORTER A1 (ABCA1). WE NOW PROPOSE TWO SEQUENTIAL CS6253 STUDIES TO DELINEATE MECHANISM AND SHOW PROOF OF CONCEPT (POC) IN HOMOZYGOUS APOE4 EARLY AD PATIENTS. IN THE RECENTLY PERFORMED PHASE 1 SAD-MAD STUDY IN HEALTHY MEN AND WOMEN CS6253 SHOWED FAVORABLE SAFETY/TOLERABILITY AND PHARMACOKINETICS (PK), APOE TARGET ENGAGEMENT AND AN AMYLOID-CLEARANCE SIGNAL CONSISTENT WITH PREVIOUS MOUSE MODEL (BOEHM, 2016) AND PRIMATE (NOVEIR, 2022) STUDIES. IN THE PHASE 1 STUDY WE ALSO PERFORMED AN EXPLORATORY IV-SC BIOEQUIVALENCE SUB-STUDY SHOWING THAT A SINGLE CS6253 SC BOLUS INJECTION OF 1 MG/KG WAS SAFE WITH A 79% BIOAVAILABILITY (COMPARED TO IV INJECTION) AND WITHIN THE EXPOSURE RANGE OF THE SUCCESSFUL TARGETED REPLACEMENT MICE STUDIES (BOEHM, 2016). WE NOW NEED TO SHOW THAT MULTIPLE-FOLD HIGHER EXPOSURE LEVELS CAN BE REACHED BY SC ROUTE OF ADMINISTRATION PRIOR TO COMMENCING PHASE 2A MECHANISM/PROOF OF CONCEPT (POC) STUDIES, COVERING A WIDER EXPOSURE RANGE, TO EVALUATE SAFETY, PK, AND PHARMACODYNAMICS (PD) EFFECTS. THUS, OUR OBJECTIVES ARE TO PERFORM A SUBCUTANEOUS (SC) INJECTION PK FEASIBILITY STUDY WITH THE ABCA1 AGONIST CS6253, AND PROVIDED PRESPECIFIED DRUG EXPOSURE SUCCESS CRITERIA ARE MET, THEN PERFORM A 28-DAY PHASE 2A MECHANISM/POC STUDY IN 48 APOE4-CARRIERS WITH MILD COGNITIVE IMPAIRMENT (MCI), OF WHICH HALF ARE HOMOZYGOUS, TO ASSESS SAFETY, TOLERANCE, PK, PLASMA AND CSF BIOMARKER EFFECTS. WE WILL ASSESS; 1) CS6253’S ABCA1 TARGET ENGAGEMENT BY FOLLOWING CHANGE IN CSF AND PLASMA APOE (TOTAL AND ISOMER SPECIFIC PROTEIN AND GLYCOSYLATION LEVELS) AND LIPIDATION (PRIMARY EFFECT); 2) TEST AMYLOID-CLEARANCE HYPOTHESIS BY FOLLOWING CSF AND PLASMA AΒ42, AΒ40, AΒ42/40-RATIO (SECONDARY); 3) ABCA1 CHOLESTEROL-TRANSPORT SALUTARY EFFECTS BY FOLLOWING PLASMA AND CSF CHANGES IN P-TAU 181, 217, 231, GFAP, NFL, AND TREM2 (TERTIARY); 4) EXPLORE DIRECT VS INDIRECT CS6253 EFFECT BY ASSESSING UPREGULATION OF NATURAL ABCA1 AGONISTS AS APOE AND SMALL APOA-I PARTICLES IN PLASMA AND CSF (EXPLORATORY); 5) INFORM ON OPTIMAL DOSING-REGIMEN, PATIENT POPULATION (HOMOZYGOUS VS HETEROZYGOUS) AND POWER FOR SUBSEQUENT PHASE 2-3 STUDIES (TRIAL PREPARATORY). WITH A POSITIVE OUTCOME FROM THESE IMPORTANT STUDIES IN THE APOE4 CARRIER PATIENT POPULATION THE NEXT REGULATORY- CLINICAL DEVELOPMENT STEPS ARE TO PROPOSE BREAKTHROUGH DESIGNATION WITH THE FDA AND ASSESS CS6253 EFFECTS ON COGNITION IN A PHASE 2-3, 9 MONTH RANDOMIZED CONTROLLED TRIAL (RCT) IN HOMOZYGOUS APOE4 CARRIERS WITH AD/ADRD. | $2.6M | FY2026 | Feb 2026 – Mar 2028 |
| Department of Education | EARLY READING FIRST | $2.6M | FY2010 | Oct 2009 – Sep 2013 |
| Department of Education | IMPACT AID PROGRAM, DISCRETIONARY CONSTRUCTION PROGRAM | $2.6M | FY2020 | Mar 2020 – Mar 2023 |
| Department of State | AWARD CONDUCTS INTERNATIONAL ELECTORAL AND POLITICAL OBSERVATION TO SUPPORT A PEACEFUL DEMOCRATIC TRANSITION IN TUNISIA. | $2.6M | FY2011 | Jul 2011 – Sep 2013 |
| Department of Education | PROJECT PREVENT | $2.6M | FY2015 | Oct 2014 – Sep 2019 |
| Department of Education | CHARTER SCHOOLS - CHARTER SCHOOLS NATIONAL ACTIVITIES COMPETITION | $2.6M | FY2007 | Oct 2006 – Sep 2010 |
| Department of Education | CHARTER SCHOOLS MANAGEMENT ORGANIZATIONS | $2.5M | FY2016 | Oct 2015 – Sep 2021 |
| Department of Education | SAFE SCHOOLS/HEALTHY STUDENTS GRANTS | $2.5M | FY2009 | Jul 2009 – Jun 2012 |
| Department of Education | STRENGTHENING INSTITUTIONS - HISPANIC SERVING INSTITUTIONS | $2.5M | FY2011 | Oct 2010 – Sep 2013 |
| Department of Education | NEW YORK CITY CHARTER SCHOOL CONSORTIUM FOR MENTAL HEALTH SERVICE PROFESSIONAL DEVELOPMENT GRANT PROGRAM | $2.5M | FY2020 | Oct 2019 – Sep 2024 |
| Department of the Treasury | PURPOSE: TO PROVIDE GRANTS TO COMMUNITY DEVELOPMENT FINANCIAL INSTITUTIONS (CDFIS) FOR THE FOLLOWING PURPOSES 1) TO EXPAND LENDING, GRANT MAKING AND INVESTMENT ACTIVITIES IN LOW OR MODERATE INCOME COMMUNITIES AND TO BORROWERS THAT HAVE HISTORICALLY EXPERIENCED SIGNIFICANT UNMET CAPITAL AND FINANCIAL SERVICES NEEDS AND WERE DISPROPORTIONATELY IMPACTED BY THE COVID 19 PANDEMIC; AND 2) TO ENABLE CDFIS TO BUILD ORGANIZATIONAL CAPACITY AND ACQUIRE TECHNOLOGY, STAFF, AND OTHER TOOLS NECESSARY TO ACCOMPLISH THE ACTIVITIES UNDER A CDFI ERP AWARD. PLANNED ACTIVITIES: ELIGIBLE ACTIVITIES INCLUDE FINANCIAL PRODUCTS, FINANCIAL SERVICES, DEVELOPMENT SERVICES, GRANTS, LOAN LOSS RESERVES AND CAPITAL RESERVES THAT MAY BE USED TO MITIGATE THE IMPACT OF THE COVID 19 PANDEMIC ON UNEMPLOYMENT, CHILDCARE, HEALTHCARE, MENTAL HEALTHCARE, AFFORDABLE HOUSING, AFFORDABLE HOUSING FINANCE, SMALL BUSINESS, SMALL FARMS, BROADBAND INTERNET, AND FOOD SUFFICIENCY. IN ADDITION, TO SUPPORT CDFIS IN BUILDING THEIR CAPACITY TO RESPOND TO THE ECONOMIC IMPACT OF COVID 19, CDFI ERP AWARDS MAY BE USED FOR COMPENSATION PERSONAL SERVICES; COMPENSATION FRINGE BENEFITS; PROFESSIONAL SERVICE COSTS; TRAVEL COSTS; TRAINING AND EDUCATION COSTS; EQUIPMENT; SUPPLIES. END GOALS: EXPANDED FINANCING FOR LOW TO MODERATE INCOME COMMUNITIES AND INDIVIDUALS THAT HAVE HISTORICALLY EXPERIENCED SIGNIFICANT UNMET CAPITAL AND FINANCIAL SERVICES NEEDS AND WERE DISPROPORTIONATELY IMPACTED BY THE COVID 19 PANDEMIC INCLUDING SPECIFIC DESIGNATED COVID IMPACTED CDFI ERP ELIGIBLE GEOGRAPHIES AS AREAS THAT MAY BENEFIT FROM CDFI ERP ASSISTANCE. BENEFICIARIES: CERTIFIED CDFIS WHICH MAY BE FOR PROFIT ORGANIZATION, PRIVATE NONPROFIT INSTITUTION/ORGANIZATION, AND OTHER PRIVATE INSTITUTION/ORGANIZATION, AS DEFINED IN 12 C.F.R. 1805, AND LOW AND MODERATE INCOME INDIVIDUALS AND FAMILIES. SUBRECIPIENTS: THERE ARE NO SUBRECIPIENTS FOR THIS PROGRAM. BROADBAND: SPECIFIC ACTIVITIES RELATING TO BROADBAND USAGE ARE NOT KNOWN AT THE TIME OF AWARD. REASON/PURPOSE OF MODIFICATION: NOT APPLICABLE. | $2.5M | FY2023 | Apr 2023 – Dec 2028 |
| Department of the Treasury | PURPOSE: TO PROVIDE GRANTS TO COMMUNITY DEVELOPMENT FINANCIAL INSTITUTIONS (CDFIS) FOR THE FOLLOWING PURPOSES 1) TO EXPAND LENDING, GRANT MAKING AND INVESTMENT ACTIVITIES IN LOW OR MODERATE INCOME COMMUNITIES AND TO BORROWERS THAT HAVE HISTORICALLY EXPERIENCED SIGNIFICANT UNMET CAPITAL AND FINANCIAL SERVICES NEEDS AND WERE DISPROPORTIONATELY IMPACTED BY THE COVID 19 PANDEMIC; AND 2) TO ENABLE CDFIS TO BUILD ORGANIZATIONAL CAPACITY AND ACQUIRE TECHNOLOGY, STAFF, AND OTHER TOOLS NECESSARY TO ACCOMPLISH THE ACTIVITIES UNDER A CDFI ERP AWARD. PLANNED ACTIVITIES: ELIGIBLE ACTIVITIES INCLUDE FINANCIAL PRODUCTS, FINANCIAL SERVICES, DEVELOPMENT SERVICES, GRANTS, LOAN LOSS RESERVES AND CAPITAL RESERVES THAT MAY BE USED TO MITIGATE THE IMPACT OF THE COVID 19 PANDEMIC ON UNEMPLOYMENT, CHILDCARE, HEALTHCARE, MENTAL HEALTHCARE, AFFORDABLE HOUSING, AFFORDABLE HOUSING FINANCE, SMALL BUSINESS, SMALL FARMS, BROADBAND INTERNET, AND FOOD SUFFICIENCY. IN ADDITION, TO SUPPORT CDFIS IN BUILDING THEIR CAPACITY TO RESPOND TO THE ECONOMIC IMPACT OF COVID 19, CDFI ERP AWARDS MAY BE USED FOR COMPENSATION PERSONAL SERVICES; COMPENSATION FRINGE BENEFITS; PROFESSIONAL SERVICE COSTS; TRAVEL COSTS; TRAINING AND EDUCATION COSTS; EQUIPMENT; SUPPLIES. END GOALS: EXPANDED FINANCING FOR LOW TO MODERATE INCOME COMMUNITIES AND INDIVIDUALS THAT HAVE HISTORICALLY EXPERIENCED SIGNIFICANT UNMET CAPITAL AND FINANCIAL SERVICES NEEDS AND WERE DISPROPORTIONATELY IMPACTED BY THE COVID 19 PANDEMIC INCLUDING SPECIFIC DESIGNATED COVID IMPACTED CDFI ERP ELIGIBLE GEOGRAPHIES AS AREAS THAT MAY BENEFIT FROM CDFI ERP ASSISTANCE. BENEFICIARIES: CERTIFIED CDFIS WHICH MAY BE FOR PROFIT ORGANIZATION, PRIVATE NONPROFIT INSTITUTION/ORGANIZATION, AND OTHER PRIVATE INSTITUTION/ORGANIZATION, AS DEFINED IN 12 C.F.R. 1805, AND LOW AND MODERATE INCOME INDIVIDUALS AND FAMILIES. SUBRECIPIENTS: THERE ARE NO SUBRECIPIENTS FOR THIS PROGRAM. BROADBAND: SPECIFIC ACTIVITIES RELATING TO BROADBAND USAGE ARE NOT KNOWN AT THE TIME OF AWARD. REASON/PURPOSE OF MODIFICATION: NOT APPLICABLE. | $2.5M | FY2023 | Apr 2023 – Apr 2028 |
| Department of Health and Human Services | THERAPEUTIC POTENTIAL OF EX VIVO EXPANDED HUMAN CORD BLOOD DERIVED CD133+ CELLS I | $2.5M | FY2008 | Sep 2008 – Mar 2012 |
| Department of Education | STUDENT EMERGENCY RELIEF | $2.5M | FY2020 | Apr 2020 – May 2022 |
| Department of Health and Human Services | MANUFACTURING OF ABCA1 AGONIST SMALL MOLECULE PEPTIDE CS6253 TO SUPPORT CHRONIC TOXICOLOGY STUDIES IN WISTAR RATS AND CYNOMOLGUS MONKEYS - PROJECT SUMMARY THE PRIMARY AIM OF THIS PROPOSAL IS TO MANUFACTURE THE ABCA1 AGONIST SMALL MOLECULE PEPTIDE CS6253 FOR UPCOMING CHRONIC TOXICOLOGY STUDIES (OUTSIDE OF THIS GRANT SCOPE) IN WISTAR RATS AND CYNOMOLGUS MONKEYS. FOLLOWING THIS, ARTERY THERAPEUTICS, INC. (ATI) PLANS TO OVERSEE THE EXECUTION OF THESE STUDIES AND THEN PROVIDE THE FDA WITH THE REPORTS INCLUDING IN SEND FORMAT. THE ULTIMATE GOAL IS TO LAY THE GROUNDWORK FOR PHASE 2-3 COGNITION TRIALS LASTING 6 MONTHS OR LONGER, FOCUSING ON PATIENTS WITH MILD COGNITIVE IMPAIRMENT (MCI) AND ALZHEIMER'S DISEASE (AD). IN ADDITION TO MANUFACTURING THE MATERIAL FOR TOXICOLOGY STUDIES, THIS CAMPAIGN WILL ALSO INCLUDE LONG-TERM STABILITY TESTING. THE DATA GENERATED WILL BE UTILIZED TO UPDATE THE DRUG MASTER FILE. CS6253 HAS DEMONSTRATED ITS SAFETY, TOLERANCE AND FAVORABLE PHARMACOKINETICS (PK) IN THE CLINICAL PHASE 1 SAD-MAD-BIOEQUIVALENCE TRIAL ATI-CS-001 (GRANT 1R44AG076299, NATIONAL CLINICAL TRIAL # 05965414). FOLLOWING THESE SUCCESSFUL PHASE 1 RESULTS IT IS IMPERATIVE TO PROCEED TO COGNITION TRIALS. COGNITION TRIALS TYPICALLY SPAN 6 TO 9 MONTHS OR LONGER AND NECESSITATE A COMPREHENSIVE TOXICOLOGY PACKAGE AFFIRMING LONG-TERM SAFETY PRIOR TO TRIAL COMMENCEMENT. THE CHRONIC TOXICOLOGY STUDIES REQUIRE APPROXIMATELY 2.3 KILOGRAMS OF GOOD MANUFACTURING PRACTICES (GMP) LIKE DRUG SUBSTANCE MATERIAL. TO MEET THIS DEMAND, WE WILL ENGAGE THE SERVICES OF AMBIOPHARM, INC, OUR TRUSTED MANUFACTURER FROM PREVIOUS CS6253 DRUG SUBSTANCE CAMPAIGNS. AMBIOPHARM IS A FULL-SERVICE CONTRACT DEVELOPMENT AND MANUFACTURING ORGANIZATION (CDMO), HAS SUCCESSFULLY PRODUCED ATI'S CS6253 NON-GMP TOXICOLOGY AND GMP CLINICAL DRUG SUBSTANCES THAT SUPPORTED THE INVESTIGATIONAL NEW DRUG (IND) APPLICATION AND THE ATI-CS-001 CLINICAL TRIAL. AMBIOPHARM CURRENTLY PRODUCES COMMERCIAL PEPTIDES UP TO MULTI-KG QUANTITIES AND HAS A QUALITY ASSURANCE SYSTEM IN PLACE FOR GMP PEPTIDES FOR CLINICAL TRIALS, AS DEMONSTRATED BY THEIR WORK WITH CS6253 AT ITS CURRENT STAGE AND WITH OTHER COMMERCIAL PEPTIDE PRODUCTS. CS6253 DRUG SUBSTANCE HAS DISPLAYED 32+ MONTHS STABILITY WHEN STORED IN -20 DEGREE C CONDITION. ALSO, THE ONGOING ICH DRUG PRODUCT STABILITY TESTING SHOWS THAT CS6253 IN SOLUTION REMAINS STABLE FOR MORE THAN 9 MONTHS IN 5 DEGREE C. | $2.5M | FY2025 | Sep 2025 – Aug 2026 |
| VA/DoDDepartment of Defense | AUTOLOGOUS BONE MARROW DERIVED MONONUCLEAR CELL THERAPY FOR COMPARTMENT SYNDROME YEAR 3 AND 4. | $2.4M | FY2011 | Sep 2011 – Sep 2016 |
| Department of Transportation | CHARLESTON COUNTY ALONG WITH BERKELEY AND DORCHESTER COUNTY, PLANS TO IMPLEMENT A FULL CAD-TO-CAD (COMPUTER AIDED DISPATCH) TO ADDRESS POST-CRASH CARE IN OVERLAPPING JURISDICTIONAL AREAS BETWEEN THE CITY OF CHARLESTON AND THE CITY OF NORTH CHARLESTON AND BERKELEY AND DORCHESTER COUNTIES, RESPECTIVELY. THE IMPLEMENTATION OF THE CAD-TO-CAD CONNECTION IS A DEMONSTRATION ACTIVITY CONNECTED TO THE BERKELEY, CHARLESTON, DORCHESTER COUNCIL OF GOVERNMENT (BCDCOG) SAFETY ACTION PLAN. | $2.4M | FY2026 | Mar 2026 – Mar 2029 |
| Department of Education | STRENGTHENING CHARTER AUTHORIZING NATIONALLY | $2.4M | FY2019 | Oct 2018 – Sep 2021 |
| Department of Education | CHARTER SCHOOLS NATIONAL ACTIVITIES COMPETITION | $2.4M | FY2015 | Mar 2015 – Mar 2019 |
| Department of Education | ADDRESSING BOTH SIDES OF CHARTER QUALITY: IMPROVING AUTHORIZING PRACTICE + GROWING QUALITY CHARTER ORGANIZATIONS THROUGH THE DISSEMINATION OF FRAMEWORKS & SUPPORTS | $2.4M | FY2019 | Oct 2018 – Sep 2021 |
| Department of Education | FACILITATING CHARTER SCHOOLS: A PROPOSAL TO CREATE A CHARTER SCHOOL FACILITY CENTER AT THE NATIONAL ALLIANCE FOR PUBLIC CHARTER SCHOOLS | $2.4M | FY2019 | Oct 2018 – Sep 2021 |
| Department of Education | IMPACT AID PROGRAM, TITLE VII, SECTION 7003 | $2.4M | — | — – Sep 2029 |
| Agency for International Development | INTERNATIONAL ELECTION OBSERVATION MISSION TO KENYA S | $2.3M | FY2017 | Apr 2017 – Aug 2018 |
| Department of Agriculture | STREAMBANK <(>&<)> BED STABILIZATION/ DEBRIS REMOVAL FOR DSRS 47-01-24-5133-412THRU422 <(>&<)> 424, 52 SITES IN CARTER COUNTY, TN (S EPTEMBER 2024 HURRICANE HELENE). | $2.3M | FY2025 | Mar 2025 – Mar 2026 |
| Department of Education | CHARTER SCHOOLS NATIONAL ACTIVITIES COMPETITION | $2.3M | FY2015 | Mar 2015 – Mar 2018 |
| Department of State | TUNISIAN CONSTITUENT ASSEMBLY ELECTION OBSERVATION | $2.3M | FY2011 | Jul 2011 – Apr 2015 |
| Agency for International Development | OBSERVING THE 2022 REFERENDUM AND PARLIAMENTARY ELECTIONS IN TUNISIA | $2.3M | FY2022 | Jul 2022 – Dec 2023 |
| Agency for International Development | ADVANCING WOMEN'S RIGHT OF ACCESS TO INFORMATION IN BANGLADESH | $2.3M | FY2016 | Aug 2016 – Feb 2022 |
| Department of Education | ESCUELA DE ARTES PLÁSTICAS Y DISEÑO DE PUERTO RICO EMERGENCY RELIEF FUND - INSTITUTIONAL PORTION | $2.2M | FY2020 | May 2020 – Jun 2025 |
| Agency for International Development | MITIGATING ELECTRCAL VIOLENCE THROUGH NATIONAL EARLY WARNING SYSTEMS (NEWS) | $2.2M | FY2015 | Feb 2015 – Jul 2019 |
| Department of Education | HEBREW PUBLIC SUPPORTING, REWARDING, AND GROWING EDUCATORS (HP SURGE) | $2.2M | FY2024 | Oct 2023 – Sep 2025 |
| Department of Education | HYDE LEADERHSUIP CHARTER SCHOOL-BROOKLYN INNOVATIVE APPROACHES TO LITERACY | $2.2M | FY2022 | Oct 2021 – Sep 2026 |
| Department of Health and Human Services | STRENGTHENING GLOBAL HEALTH SECURITY THROUGH SURVEILLANCE, PREVENTION, AND RESPONSE WITH A FOCUS ON STRENGTHENING DATA AND HEALTH INFORMATION SYSTEMS - SEE ATTACHMENT | $2.2M | FY2025 | Sep 2025 – Sep 2030 |
| Department of Housing and Urban Development | NEIGHBORHOOD STABILIZATION PRG | $2.1M | FY2009 | Oct 2008 – Aug 2009 |
| Department of Education | FRIENDSHIP SEEKS TO REPLICATE ITS HIGH SCHOOL CLUSTER MODEL OF FEEDER SCHOOLS FROM ITS NETWORK. ARMSTRONG, IDEAL AND WOODRIDGE WILL BE FEEDER SCHOOLS FOR THE FUTURE FRIENDSHIP COLLEGIATE WEST. | $2.1M | FY2025 | Apr 2025 – Mar 2027 |
| Department of Education | A PROPOSAL TO CREATE THE CHARTER SCHOOL COLLABORATIVE TO ACCELERATE STUDENT LEARNING IN RESPONSE TO THE COVID-19 PANDEMIC | $2.1M | FY2023 | Oct 2022 – Sep 2025 |
| Department of Education | HYDE LEADERSHIP CHARTER SCHOOL-BROOKLYN SUPPORTING POSITIVE, ASPIRATIONAL, AND RESPONSIBLE KIDS (SPARK) | $2.1M | FY2020 | Oct 2019 – Sep 2024 |
| Department of Education | ENRICH - ENGAGING NEW READERS IN A COMMUNITY OF HIGH-NEED | $2.1M | FY2019 | Oct 2018 – Sep 2021 |
| Department of Education | CHARTER SCHOOLS MANAGEMENT ORGANIZATIONS | $2M | FY2017 | Oct 2016 – Sep 2021 |
| VA/DoDDepartment of Veterans Affairs | VA IS PROVIDING PER DIEM FUNDING TO ASSIST WITH THE OPERATIONAL COSTS ASSOCIATED WITH TRANSITIONAL HOUSING BEDS FOR HOMELESS VETERANS. | $2M | — | — – — |
| Department of Education | EDUCATING FOR EXCELLENCE: CREATING AND SUSTAINING DIVERSE AND EFFECTIVE CHARTER SCHOOL LEADERSHIP THROUGH THE DISSEMINATION OF PROGRAMS & SUPPORTS | $2M | FY2023 | Oct 2022 – Sep 2025 |
| Department of Education | CHARTER SCHOOLS NATIONAL ACTIVITIES COMPETITION | $2M | FY2015 | Mar 2015 – Mar 2018 |
| Department of Education | CAROL M. WHITE PHYSICAL EDUCATION PROGRAM | $2M | FY2014 | May 2014 – Apr 2017 |
| Department of Housing and Urban Development | NEIGHBORHOOD STABILIZATION PRG | $2M | FY2009 | Oct 2008 – Aug 2009 |
| Department of Education | FULL SERVICE COMMUNITY SCHOOLS PROGRAM | $2M | FY2011 | Oct 2010 – Sep 2015 |
| Department of Housing and Urban Development | ECONOMIC DEVELOPMENT INITIATIVE, COMMUNITY PROJECT FUNDING, AND MISCELLANEOUS GRANTS | $2M | FY2023 | Feb 2023 – Aug 2030 |
| Department of Commerce | THIS EDA INVESTMENT SUPPORTS THE CHARTER TOWNSHIP OF MUNDY WITH UPGRADING THE CRITICAL WATER AND ROAD INFRASTRUCTURE TO SERVE INDUSTRIAL USERS' REQUIREMENTS FOR WATER PRESSURE AND TRUCK ACCESS IN GENESEE COUNTY, MICHIGAN. THE PROJECT WORK INCLUDES UPGRADING APPROXIMATELY 800 FEET OF SANITARY SEWER, 9500 FEET OF WATER MAIN, 3175 FEET OF STORM SEWER, DRAIN EXTENSIONS AND DETENTION AREAS. ONCE COMPLETED, THE PROJECT WILL SUPPORT EXISTING MANUFACTURING BUSINESSES, ATTRACT NEW PRIVATE INVESTMENT, AND CREATE JOBS IN HEALTHCARE, MANUFACTURING, AND TECHNOLOGY SECTORS. | $2M | — | — – — |
| Department of the Treasury | FINANCIAL ASSISTANCE AWARD | $2M | — | — – — |
| Department of the Treasury | FINANCIAL ASSISTANCE AWARD | $2M | — | — – — |
| Department of Commerce | WATER TREATMENT PLANT | $2M | FY2014 | Sep 2014 – Mar 2016 |
| Agency for International Development | THE GRANTEE WILL DEPLOY A LONG-TERM ELECTION OBSERVATION MISSION TO ASSESS TUNISIA¿S PARLIAMENTARY AND PRESIDENTIAL ELECTIONS. RIGOROUS INDEPENDENT OBSERVATION ACTIVITIES, PAIRED WITH PRIVATE ADVOCACY AND PUBLIC REPORTING, SERVE TO SUPPORT TUNISIA¿S ELECTORAL AUTHORITIES WITH TIMELY, CONSTRUCTIVE RECOMMENDATIONS WHILE INCREASING TRANSPARENCY OF AND PUBLIC CONFIDENCE IN THE POLLS AND TABULATION PROCESSES. | $2M | FY2019 | May 2019 – Sep 2020 |
| Department of Health and Human Services | PHASE 1/2A CLINICAL STUDY OF DESCARTES-30 IN ACUTE RESPIRATORY DISTRESS SYNDROME - ABSTRACT THIS APPLICATION IS TO SUPPORT A CLINICAL TRIAL OF THE FIRST MRNA ENGINEERED CELL THERAPY FOR ACUTE RESPIRATORY DISTRESS SYNDROME (ARDS), INCLUDING ARDS CAUSED BY COVID-19. THE FDA HAS ALREADY REVIEWED THE IND APPLICATION AND DETERMINED THAT THE STUDY MAY PROCEED. ARDS IS A SEVERE INFLAMMATORY RESPIRATORY FAILURE THAT KILLS AN ESTIMATED 80,000 AMERICANS EACH YEAR. 80% OF ARDS PATIENTS REQUIRE MECHANICAL VENTILATION. NO FDA-APPROVED THERAPIES FOR ARDS ARE AVAILABLE. ARDS MAY RESULT FROM INFECTIOUS OR NON-INFECTIOUS (E.G., TRAUMATIC OR CHEMICAL) INSULTS. COVID-19 IS CURRENTLY THE MOST COMMON CAUSE OF ARDS, AND THE VAST MAJORITY OF COVID-19 DEATHS ARE DUE TO ARDS. NEUTROPHIL EXTRACELLULAR TRAPS (NETS) DRIVE THE HYPERACTIVE INFLAMMATORY RESPONSE IN ARDS AND COVID-19, AND PRESENCE OF NETS CORRELATES STRONGLY WITH ARDS SEVERITY. NETS ARE PRODUCED BY LOCALLY-TRAFFICKED NEUTROPHILS UNDERGOING NETOSIS, A PROGRAMMED CELL DEATH WHERE THE CELLS LYSE TO SECRETE DNA DECORATED WITH INFLAMMATORY PROTEINS. LOW AMOUNTS OF NETS ARE THOUGHT TO HELP ENTRAP INFECTION, BUT HYPERACTIVATED NEUTROPHILS PRODUCE LARGE QUANTITIES OF NETS THAT CAUSE HYPOXIA AND IMMUNE THROMBI DUE TO PHYSICAL BLOCKADE OF ALVEOLI AND MICROVASCULATURE. A NET-DEGRADING THERAPY THEREFORE WOULD BE A SIGNIFICANT ADVANCE IN TREATMENT OF ARDS. DESCARTES-30 IS THE FIRST ALLOGENEIC (I.E., OFF-THE-SHELF) ENGINEERED HUMAN MESENCHYMAL STEM CELL (MSC) THERAPY SECRETING A COMBINATION OF TWO POTENT NET-DEGRADING ENZYMES. IN THIS PHASE 1/2A STUDY, THE HYPOTHESIS TO BE TESTED IS THAT DESCARTES-30 WILL BE WELL TOLERATED AND SHOW EVIDENCE OF EFFICACY IN PATIENTS WITH MODERATE TO SEVERE ARDS AND COVID- 19. AIMS ARE TO DETERMINE THE MAXIMUM TOLERATED DOSE AND EVIDENCE OF PRELIMINARY EFFICACY, DEFINE PHARMACOKINETIC PROPERTIES AND BIOLOGIC CORRELATES OF DISEASE, AND ESTABLISH A VALIDATED POTENCY ASSAY FOR USE IN LATER-STAGE CLINICAL DEVELOPMENT. THESE DATA WILL INFORM THE DESIGN OF A CONTROLLED REGISTRATION STUDY IN PATIENTS WITH MODERATE-TO-SEVERE ARDS. | $2M | FY2021 | May 2021 – Apr 2024 |
| Department of Health and Human Services | AUTOLOGOUS T-CELLS EXPRESSING A CHIMERIC ANTIGEN RECEPTOR DIRECTED TO B-CELL MATURATION ANTIGEN (BCMA) IN PATIENTS WITH GENERALIZED MYASTHENIA GRAVIS (MG) | $2M | FY2020 | Apr 2020 – Mar 2022 |
| Department of Health and Human Services | PHASE 1/2 CLINICAL STUDY OF HUMANIZED ANTI-BCMA CAR T CELLS IN RELAPSED/REFRACTORY MULTIPLE MYELOMA (MM) | $2M | FY2018 | Aug 2018 – Apr 2022 |
| Department of Education | CHARTER SCHOOLS NATIONAL ACTIVITIES COMPETITION | $2M | FY2015 | Mar 2015 – Mar 2019 |
Department of Education
$63.2M
NEW JERSEY CHARTER SCHOOLS PROGRAM STATE ENTITIES GRANT (PROJECT CULTIVATE 38)
Department of Health and Human Services
$51.6M
HEALTH CENTER CLUSTER
Department of Health and Human Services
$45.5M
HEALTH CENTER CLUSTER
Department of Education
$39.6M
GREAT SCHOOLS COLORADO CSP PROJECT
Department of Education
$31.9M
NEW MEXICO CHARTER SCHOOLS PROGRAM GRANT PROJECT
Department of Education
$30M
PENNSYLVANIA CSP GRANT PROGRAM
Department of Education
$20M
GROWING HIGH QUALITY CHARTER SCHOOLS
Department of Education
$19.7M
WASHINGTON INNOVATION AND EXCELLENCE CSP GRANT PROGRAM
Department of Education
$17.3M
FUND FOR HIGH-POTENTIAL AND UNDERSERVED CHARTER SCHOOLS
Department of Education
$16.3M
PRESCHOOL DEVELOPMENT GRANTS - DEVELOPMENT
Department of Education
$15.6M
UTAH CHARTER SCHOOLS PROGRAM (UCSP) GRANT PROJECT
Department of Education
$14.9M
ILLINOIS IMPACT INITIATIVE: CREATING AND EXPANDING HIGH-QUALITY EDUCATIONAL OPPORTUNITIES FOR ILLINOIS’ MOST UNDERSERVED STUDENTS AND COMMUNITIES.
Department of Education
$14.7M
GREAT SCHOOLS FOR CONNECTICUT CSP PROEJCT
Agency for International Development
$13M
GH/HIDN/ID 936-3100 AAD
Department of Education
$12.3M
GAINING EARLY AWARENESS AND READINESS FOR UNDERGRADUATE PROGRAMS (GEAR UP PARTNERSHIP)
Department of Education
$12.1M
SECURING SUCCESS FOR ALL NEW YORK CITY CHILDREN
Department of Education
$10.2M
THE MARYLAND MOMENTUM PROJECT IS SUBMITTED TO CONTINUE THE GROWTH OF HIGH-QUALITY CHARTER SCHOOLS ACROSS THE STATE OF MARYLAND.
Department of Health and Human Services
$10M
ARRA - FACILITY INVESTMENT PROGRAM
Environmental Protection Agency
$10M
DESCRIPTION:THIS ACTION PROVIDES PARTIAL FUNDING IN THE AMOUNT OF $550,000 TO SUPPORT THE STARTEX-JACKSON-WELLFORD-DUNCAN WATER DISTRICT IN SOUTH CAROLINA TO IMPLEMENT ITS PROJECT TO REPLACE THE WATER TREATMENT PLANT'S 250,000 GALLONS CLEARWELL AND 5 MILLION GALLONS (MG) RECTANGULAR CLEARWELL WITH A NEW 7.5 MILLION GALLONS (MG) PRESTRESSED CONCRETE GROUND STORAGE TANK AS DIRECTED IN THE 2024 CONSOLIDATED APPROPRIATIONS ACT OR AS IDENTIFIED IN AN APPROVED TECHNICAL CORRECTION IF ONE HAS BEEN APPROVED FOR THIS PROJECT. ACTIVITIES:THE ACTIVITIES INCLUDE THE CONSTRUCTION OF A NEW 7.5 MILLION GALLONS (MG) TANK ADJACENT TO THE EXISTING 5 MILLION GALLONS (MG) CLEARWELL NEXT TO THE MIDDLE TYGER HIGH SERVICE PUMP STATION. THE OLD 250,000 GALLONS AND 5 MILLION GALLONS (MG) CLEARWELLS WILL BE ABANDONED IN PLACE AND EVENTUALLY DEMOLISHED UPON INITIATION OF CONSTRUCTION TO REPLACE THE CONVENTIONAL TREATMENT PLANT.SUBRECIPIENT:NO SUBAWARDS ARE INCLUDED IN THIS ASSISTANCE AGREEMENT.OUTCOMES:THE ANTICIPATED DELIVERABLE INCLUDES AN INCREASE TO THE OVERALL FINISHED WATER CAPACITY NEEDS FROM 10 MILLION GALLONS (MG) TO 12.5 MILLION GALLONS (MG) AT THE STARTEX-JACKSON-WELLFORD-DUNCAN WATER DISTRICT'S WATER TREATMENT PLANT. THE EXPECTED OUTCOMES INCLUDE BECOMING MORE EFFICIENT AND COST EFFECTIVE IN OVERALL TREATMENT AND WATER PRODUCTION OPERATIONS, AND THE CONTINUED PRODUCTION OF SAFE AND RELIABLE DRINKING WATER. THE INTENDED BENEFICIARIES INCLUDE THE RESIDENTS OF THE STARTEX-JACKSON-WELLFORD-DUNCAN WATER DISTRICT IN THE STATE OF SOUTH CAROLINA.
Department of Education
$9.8M
MISSION POSSIBLE: SECURING SUCCESS FOR NYC CHILDREN
Department of Health and Human Services
$9.6M
SUSTAINABLE SURVEILLANCE AT SCALE: DHIS2 AS A PLATFORM FOR IMPROVING GLOBAL CAPACITY TO PREVENT, DETECT & RESPOND TO PUBLIC HEALTH THREATS
Department of Education
$9M
TRIPLING ENROLLMENT IN WEST VIRGINIA'S CHARTER SECTOR IN 5 YEARS
Department of Education
$8.7M
CHARTER SCHOOLS MANAGEMENT ORGANIZATIONS
Agency for International Development
$8.5M
TO ACHIEVE ELIMINATION OF ONCHOCERCIASIS IN THE AMERICAS, THE UNITED STATES AGENCY FOR INTERNATIONAL DEVELOPMENT (USAID), BUREAU FOR GLOBAL HEALTH (GH), NEGLECTED TROPICAL DISEASES DIVISION PROPOSES A COOPERATIVE AGREEMENT (CA) FOR THE CONTROL AND ELIMINATION PROJECT FOR NEGLECTED TROPICAL DISEASES, ELEMENT 3, HEREBY ACHIEVE ONCHOCERCIASIS ELIMINATION IN THE AMERICAS (ACHIEVE OEA). THE PURPOSE OF ACHIEVE OEA IS TO ONCHOCERCIASIS IN THE LAST TWO FOCI IN THE AMERICAS.
Department of Education
$8.1M
CHARTER SCHOOLS MANAGEMENT ORGANIZATIONS
Department of Homeland Security
$8.1M
ASSISTANCE TO FIREFIGHTERS GRANT
Department of Education
$8.1M
INSPIRENOLA CONSORTIUM: REPLICATING HIGH QUALITY EDUCATION IN LOUISIANA
Department of Homeland Security
$8M
STAFFING FOR ADEQUATE FIRE AND EMERGENCY RESPONSE (SAFER)
Department of Housing and Urban Development
$7.2M
ECONOMIC DEVELOPMENT INITIATIVE, COMMUNITY PROJECT FUNDING, AND MISCELLANEOUS GRANTS
Department of Education
$7M
TEACHER INCENTIVE FUND
Department of Education
$7M
CHARTER SCHOOLS MANAGEMENT ORGANIZATIONS
Agency for International Development
$7M
ACCESS TO JUSTICE PROGRAM
Agency for International Development
$6.9M
THE PURPOSE OF THIS MOD IS TO:- - INCREMENTALLY FUND THE COOPERATIVE AGREEMENT IN THE AMOUNT OF $2,112,421.00
Agency for International Development
$6.8M
AWARD TO CARTER CENTER FOR INDIGENOUS CONFLICT MANAGEMENT
Agency for International Development
$6.5M
NEW ELECTIONS OBSERVATION ACTIVITY
Department of Education
$6.5M
CHARTER SCHOOLS MANAGEMENT ORGANIZATIONS
Department of Education
$6.1M
CHARTER SCHOOLS MANAGEMENT ORGANIZATIONS
Department of Education
$6M
CHARTER SCHOOLS MANAGEMENT ORGANIZATIONS
Department of Education
$5.6M
SECURING SUCCESS FOR ALL NEW YORK CITY CHILDREN
Department of Transportation
$5.6M
APPLICATION PURPOSE: THE PURPOSE OF THIS GRANT IS TO CONSTRUCT AN INTERMODAL TRANSPORTATION CENTER.; ACTIVITIES PERFORMED: THIS PROJECT WILL FUND THE CONSTRUCTION OF AN INTERMODAL TRANSPORTATION BUILDING WITH THREE FULL STORIES ON APPROXIMATELY 8.67 ACRES AT ITS WATERFRONT. THE PROJECT SITE WILL INCLUDE A MIXED-USE INTERMODAL TRANSPORTATION CENTER CONSISTING OF A PASSENGER TERMINAL AND PORT AUTHORITY OFFICE SPACE. THE PROJECT SITE WILL ALSO CONNECT TO A 20-FOOT-WIDE ELEVATED PEDESTRIAN BOARDWALK FIXED PIER FLOATING DOCKS WAVE SCREEN AND HANDICAP ACCESS RAMP; EXPECTED OUTCOMES: THE CARTERET FERRY TERMINAL PROJECT IS CENTRAL TO REVITALIZING THE BOROUGHS WATERFRONT PROVIDING AFFORDABLE TRANSPORTATION AND CREATING ECONOMIC OPPORTUNITIES.; INTENDED BENEFICIARIES: CENTRAL NEW JERSEY RESIDENTS.; SUBRECIPIENT ACTIVITIES: NONE
Department of Education
$5.5M
REPLICATING ZETA'S HIGH-QUALITY CHARTER SCHOOLS
Department of Health and Human Services
$5.3M
FAMILY PLANNING PROJECT INCLUDING HIV INTEGRATION TO FAMILY PLANNING SERVICES
Department of Education
$5.3M
CHARTER SCHOOLS - CHARTER SCHOOLS NATIONAL ACTIVITIES COMPETITION
Department of Agriculture
$5.3M
FOOD FOR PROGRESS; TO PROVIDE AG COMODTYS TO DEVELOPING COUNTRIES & EMERGING DEMOCRACIES TO INTRODUCE & EXPAND FREE ENTERPRISE IN THE AG SECTOR
Department of Agriculture
$4.8M
GRANT FOR PROD OF ADV BIOFUEL
Department of Agriculture
$4.8M
WASTE DISPOSAL GRANTS - 09/10 STIMULUS
Department of Health and Human Services
$4.7M
EARLY HEAD START
Department of Education
$4.5M
CITIZENS OF THE WORLD CHARTER SCHOOLS - LOS ANGELES GROWTH PLAN
Department of Education
$4.3M
MISSISSIPPI CHARTER SCHOOL AUTHORIZER BOARD 2017 CSP GRANT
Department of Education
$4.2M
CHARTER SCHOOLS - CHARTER SCHOOLS NATIONAL ACTIVITIES COMPETITION
Department of Education
$4.1M
CHARTER SCHOOLS MANAGEMENT ORGANIZATIONS
Agency for International Development
$4.1M
THE ABOVE GRANT ISSUED UNDER APS M-OAA-GRO-LMA-08-279 TO CONDUCT INTERNATIONAL OBSERVATION ACTIVITIES FROM THE ESTABLISHMENT OF THE COMPREHENSIVE PEA
Department of Health and Human Services
$4.1M
AMERICAN RESCUE PLAN ACT FUNDING FOR HEALTH CENTERS
Department of Health and Human Services
$4M
HEAD START
Department of Housing and Urban Development
$4M
PURPOSE: ECONOMIC DEVELOPMENT INITIATIVE, COMMUNITY PROJECT FUNDING/CONGRESSIONAL DIRECTED SPENDING AWARDS ARE AUTHORIZED UNDER THE CONSOLIDATED APPROPRIATIONS ACT, 2022 PUBLIC LAW 117-328 AND THE EXPLANATORY STATEMENT FOR DIVISION L OF THAT ACT. PROJECTS SELECTED FOR COMMUNITY PROJECT FUNDING/CONGRESSIONAL DIRECTED SPENDING ARE LISTED IN THE JOINT EXPLANATORY STATEMENT (JES) THAT ACCOMPANIES A SPECIFIC FISCAL YEAR’S APPROPRIATIONS ACT OR CONGRESSIONAL RECORD. THE JES LISTS PROJECT, RECIPIENT, STATE, AMOUNT AND CONGRESSIONAL SPONSOR.; ACTIVITIES TO BE PERFORMED: ECONOMIC DEVELOPMENT INITIATIVE, COMMUNITY PROJECT FUNDING/CONGRESSIONALLY DIRECTED SPENDING AWARD PROJECTS INCLUDE A WIDE VARIETY OF ACTIVITIES THAT RESULT IN ECONOMIC DEVELOPMENT OR COMMUNITY DEVELOPMENT OUTCOMES. HUD WILL NOT KNOW THE FULL SCOPE OF THE PROJECT UNTIL THE RECIPIENT SUBMITS THE REQUIRED PROJECT NARRATIVE AND CONFIRMS ALIGNMENT WITH THE LANGUAGE AS PROVIDED IN THE CONGRESSIONAL RECORD. TO FIND THE DETAILS OF THE GRANT AWARD AS WRITTEN WITHIN THE CONGRESSIONAL RECORD USE THE FOLLOWING LINK AND PATH SELECTIONS TO GET TO THE DESCRIPTION OF THE ECONOMIC DEVELOPMENT INITIATIVE, COMMUNITY PROJECT FUNDING GRANTS HTTPS://WWW.HUD.GOV/PROGRAM_OFFICES/COMM_PLANNING/EDI-GRANTS, SELECT THE FISCAL YEAR OF INTEREST, SCROLL DOWN TO PROGRAM LAWS AND REGULATIONS, UNDER FISCAL YEAR 20XX CONSOLIDATED APPROPRIATIONS ACT, 20XX: CONGRESSIONAL RECORD (JOINT EXPLANATORY STATEMENT).; EXPECTED OUTCOMES: COMPLETION OF THE PROJECT AS DESCRIBED IN THE JOINT EXPLANATORY STATEMENT (JES) PROJECT DESCRIPTION AND SUBSEQUENT APPROVED PROJECT NARRATIVE.; INTENDED BENEFICIARIES: THE PROJECT BENEFICIARIES ARE THE INDIVIDUALS AND/OR ORGANIZATIONS THAT ARE AWARDED GRANT FUNDS OR SERVED BY THE ENTITIES THAT ARE AWARDED GRANT FUNDS AS IDENTIFIED IN THE JES RECIPIENT OR PROJECT DESCRIPTION SECTIONS.; SUBRECIPIENT ACTIVITIES: THE SUBRECIPIENT ACTIVITIES ARE UNKNOWN AT THE TIME OF AWARD.
Agency for International Development
$4M
CARTER CENTER ELECTION PROGRAM
Department of Education
$4M
ALL TRIBES CAREER TECHNICAL EDUCATION PROGRAM HOME
Department of Justice
$3.9M
WAYNE COUNTY PROSECUTOR'S OPERATION RELENTLESS PURSUIT
Department of Health and Human Services
$3.8M
FAMILY PLANNING SERVICES GRANT
Department of Transportation
$3.8M
IMPROVE EXISTING AIRPORT
Department of Health and Human Services
$3.8M
TITLE X FAMILY PLANNING PROGRAM NON-COMPETING APPLICATION 2017-2018
Department of Education
$3.7M
CHARTER SCHOOLS MANAGEMENT ORGANIZATIONS
Department of Health and Human Services
$3.5M
HEAD START
Department of Education
$3.5M
HIGHER EDUCATION RELIEF FUNDS FOR STUDENTS
Agency for International Development
$3.5M
THE CARTER CENTER MONITORING NEPAL'S PEACE AND CONSTITUTION DRAFTING
Department of Education
$3.5M
VOLUNTARY SCHOOL CHOICE
Department of Education
$3.4M
HIGHER EDUCATION RELIEF FUNDS FOR STUDENTS
Department of Education
$3.4M
HIGHER EDUCATION RELIEF FUNDS FOR INSTITUTION
Environmental Protection Agency
$3.4M
DESCRIPTION:THIS AGREEMENT PROVIDES FUNDING TO ROYAL OAK CHARTER TOWNSHIP TO IMPLEMENT ITS PROJECT TO REPLACE AGING WATER MAINS AS DIRECTED IN THE 2022, 2023, AND 2024 CONSOLIDATED APPROPRIATIONS ACTS OR AS IDENTIFIED IN AN APPROVED TECHNICAL CORRECTION IF ONE HAS BEEN APPROVED FOR THIS PROJECT. THIS PROJECT USES FUNDING APPROPRIATED FROM FY22, FY23, AND FY24.ACTIVITIES:THE ACTIVITIES TO BE PERFORMED ARE THE REPLACEMENT OF UNDERSIZED AND LEAD SERVICE LINES AND MAINS IN ROYAL OAK CHARTER TOWNSHIP.SUBRECIPIENT:NO SUBAWARDS ARE INCLUDED IN THIS ASSISTANCE AGREEMENT.OUTCOMES:THE ANTICIPATED DELIVERABLES ARE IMPROVED WATER DELIVERY, WHICH ARE EXPECTED TO LEAD TO MORE RELIABLE WATER SERVICE TO THE PEOPLE OF ROYAL OAK CHARTER TOWNSHIP.
Department of Commerce
$3.3M
DS-19 AIRPORT HANGAR
Department of Education
$3.3M
CHARTER SCHOOLS - CHARTER SCHOOLS NATIONAL ACTIVITIES COMPETITION
Department of Homeland Security
$3.2M
STAFFING FOR ADEQUATE FIRE AND EMERGENCY RESPONSE (SAFER)
Department of Education
$3.1M
INSTITUTIONAL PORTION COVID-19 EMERGENCY RELIEF GRANT
Department of Education
$3.1M
IMPACT AID PROGRAM, TITLE VII, SECTION 7003
Department of Education
$3.1M
NYC IN BALANCE
Environmental Protection Agency
$3M
DESCRIPTION:THIS AGREEMENT PROVIDES FUNDING TO BERLIN CHARTER TOWNSHIP TO IMPLEMENT ITS WASTEWATER DISCHARGE LINE PROJECT AS DIRECTED IN THE 2023 CONSOLIDATED APPROPRIATIONS ACT OR AS IDENTIFIED IN AN APPROVED TECHNICAL CORRECTION IF ONE HAS BEEN APPROVED FOR THIS PROJECT. ACTIVITIES:THE ACTIVITIES TO BE PERFORMED INCLUDE THE EXECUTION AND IMPLEMENTATION OF A WASTEWATER INFRASTRUCTURE CONSTRUCTION PROJECT. WORKPLAN ACTIVITIES CONSIST OF: CONSTRUCTION OF APPROXIMATELY 12,000 LINEAL FEET OF FORCE MAIN AND APPURTENANCES, ADDITION OF ONE NEW EFFLUENT PUMP, AND RESTORATION OF AREAS DISTURBED BY CONSTRUCTION. SUBRECIPIENT:NO SUBAWARDS ARE INCLUDED IN THIS ASSISTANCE AGREEMENT.OUTCOMES:THE ANTICIPATED DELIVERABLES INCLUDE INSTALLATION OF APPROXIMATELY 12,000 LINEAL FEET OF FORCE MAIN AND ONE NEW EFFLUENT PUMP. THE EXPECTED OUTCOMES INCLUDE PROTECTING WATER QUALITY IN LAKE ERIE BY PREVENTING FAILURE OF THE FORCE MAIN, REPLACING AGING INFRASTRUCTURE, AND MAINTAINING AFFORDABLE SEWER RATES. THE INTENDED BENEFICIARIES INCLUDE RESIDENTS OF BERLIN CHARTER TOWNSHIP.
Department of Education
$3M
NEW YORK CITY CHARTER SCHOOL CONSORTIUM FOR SCHOOL CLIMATE TRANSFORMATION
Department of Housing and Urban Development
$3M
ECONOMIC DEVELOPMENT INITIATIVE, COMMUNITY PROJECT FUNDING, AND MISCELLANEOUS GRANTS
Department of Education
$3M
INVESTING IN INNOVATION - DEVELOPMENT GRANTS
Department of Health and Human Services
$3M
MANUFACTURING RNA-BASED CAR T CELLS TO COMBAT AUTOANTIBODY-ASSOCIATED AUTOIMMUNE DISORDERS (AAAD) - AUTOANTIBODY-ASSOCIATED AUTOIMMUNE DISEASES (AAADS) ARE DISORDERS IN WHICH DYSFUNCTIONAL PLASMA CELLS (PCS) SECRETE AUTOANTIBODIES THAT ATTACK HEALTHY TISSUE. MANY AAADS ATTACK THE NERVOUS SYSTEM, SUCH AS MYASTHENIA GRAVIS (MG), NEUROMYELITIS OPTICA, CHRONIC INFLAMMATORY DEMYELINATING POLYNEUROPATHY, LAMBERT- EATON SYNDROME, AND NECROTIZING AUTOIMMUNE MYOPATHY. THIS R44 (CLINICAL TRIAL NOT ALLOWED) WILL SUPPORT MANUFACTURING OF A NEW RNA-BASED CELL THERAPY FOR NEUROLOGICAL AAADS, AND ANALYSIS OF BIOMARKERS FROM PATIENTS WHO RECEIVED THE THERAPY. CHIMERIC ANTIGEN RECEPTOR T CELL (CAR-T) THERAPY ELIMINATES PATHOGENIC CELLS, SUCH AS PCS, BY EXPRESSING ENGINEERED CHIMERIC ANTIGEN RECEPTORS (CAR) IN T CELLS ISOLATED FROM A PATIENT; THE T CELLS ARE THEN REINFUSED TO KILL THE CAR’S TARGET. ALL APPROVED CAR T DRUGS RELY ON GENE TRANSFER BY DNA, WHICH PERMANENTLY MODIFIES THE GENOME. THIS POSES SEVERAL PROBLEMS. DNA-MODIFIED CAR-T CELLS MULTIPLY EXPONENTIALLY BECAUSE CAR DNA REPLICATES; THIS CAN CAUSE LIFE-THREATENING INFLAMMATION CALLED CYTOKINE RELEASE SYNDROME (CRS). THESE CAR-T CELLS ALSO REQUIRE PRE-TREATMENT CHEMOTHERAPY TO CREATE A NICHE FOR CELL PROLIFERATION. DNA-MODIFIED CAR-T CELLS ARE EXPENSIVE TO MAKE AND USE CLINICALLY, BECAUSE FREQUENT ADVERSE EVENTS REQUIRE CLOSE PATIENT MONITORING. THESE HURDLES HAVE LIMITED CAR-T THERAPY ONLY TO ADVANCED CANCERS. CARTESIAN THERAPEUTICS HAS DESIGNED A NEW APPROACH THAT REPLACES DNA WITH RNA TO ACHIEVE TRANSIENT, TUNABLE CAR EXPRESSION (RCAR-T). UNLIKE DNA-MODIFIED CAR T CELLS, CAR-ENCODING RNA CANNOT REPLICATE AND DECAYS IN PREDICTABLE FASHION. THUS, THE PATIENT’S EXPOSURE TO RCAR-T CELLS IS DETERMINED BY CELL DOSE. THIS AVOIDS CRS AND ELIMINATES LYMPHODEPLETING CHEMOTHERAPY. THESE ADVANCES CREATE A VERSATILE, CLINICALLY-VALIDATED MEANS TO TREAT NEUROLOGICAL AAADS. WE HAVE DEVELOPED AN RCAR-T THAT TARGETS B CELL MATURATION ANTIGEN (BCMA). THIS MARKER IS EXPRESSED ON PCS – CELLS THAT PRODUCE AUTOANTIBODIES IN AAADS. THIS THERAPY – “DESCARTES-08” – TRANSIENTLY EXPRESSES ANTI-BCMA CAR TO TARGET BCMA+ PCS AFTER INFUSION. MG IS AN AAAD IN WHICH BCMA+ PCS SECRETE AUTOANTIBODIES THAT ATTACK THE NEUROMUSCULAR JUNCTION, CAUSING SEVERE MUSCLE WEAKNESS. IN THE FIRST SUCCESSFUL PHASE 2A TRIAL OF A CELL THERAPY TO TREAT AUTOIMMUNITY (NCT04146051), DESCARTES-08 CONFERRED POTENT, SAFE, AND LONG-LASTING IMPROVEMENT IN MG PATIENTS FOR 12 MONTHS OR MORE, EVEN THOUGH TREATMENT WAS ONLY 6-WEEKS (LANCET NEUROLOGY 2023). THESE BENEFITS WERE ACHIEVED WITHOUT THE TOXICITY, INPATIENT STAYS, OR LYMPHODEPLETION NEEDED IN DNA-BASED CAR-TS. HERE WE PROPOSE KEY STEPS TO DEVELOP RCAR-T AS A NEW CELL THERAPY OPTION TO TREAT NEUROLOGICAL AAADS. THE AIMS ARE I) MANUFACTURE DESCARTES-08 PRODUCT LOTS TO COMPLETE THE PHASE 2 MG CLINICAL TRIAL, II) IDENTIFY CLINICAL CORRELATES IN PATIENT SAMPLES FROM ONGOING RANDOMIZED PLACEBO-CONTROLLED TRIAL (RCT) AND III) MANUFACTURE DESCARTES-08 LOTS FOR EXPANDED ACCESS AND BASKET TRIAL PATIENTS WITH OTHER NEUROLOGICAL AAADS. COMPLETING THESE AIMS WILL POSITION DESCARTES-08 TO BECOME THE FIRST COMMERCIAL RCAR-T PRODUCT FOR A VARIETY OF AAADS.
Department of Health and Human Services
$3M
ONCHOCERCIASIS ELIMINATION PROGRAM FOR THE AMERICAS
Department of Health and Human Services
$3M
A RANDOMIZED DOUBLE-BLIND PLACEBO CONTROLLED PHASE 1 SAD STUDY IN MALE AND FEMALE HEALTHY VOLUNTEERS TO ASSESS SAFETY, PHARMACOKINETICS, AND TRANSIENT BIOMARKER CHANGES BY THE ABCA1 AGONIST CS6253 - PROJECT SUMMARY LATE-ONSET OR SPORADIC ALZHEIMER'S DISEASE (AD) CONSTITUTE 95 PERCENT OF ALL AD AND APOE4 IS THE DOMINATING GENETIC RISK FACTOR. WHILE THERE ARE THREE MAJOR APOE ALLELIC VARIANTS (APOE2, APOE3, AND APOE4), APOE4 CARRIERS HAVE AN INCREASED RISK OF DEVELOPING AD, AND UP TO 66% OF INDIVIDUALS WITH AD-TYPE DEMENTIA CASES AND 64% WITH MILD COGNITIVE IMPAIRMENT, ALSO CARRY THE APOE4 ALLELE. THERE ARE CURRENTLY NO TREATMENTS FOR APOE4 DRIVEN AD OR OTHER DEMENTIAS. ARTERY THERAPEUTICS, INC. (ARTERY; ATI) HAS DEVELOPED A NOVEL CHEMICAL ENTITY FOR THE TREATMENT OF APOE4 DRIVEN DEMENTIAS, INCLUDING AD. CS6253 IS A 2ND-GENERATION SELECTIVE ATP- BINDING-CASSETTE A1 (ABCA1) TRANSPORTER AGONIST PEPTIDE DERIVED FROM THE C-TERMINAL OF APOE. CS6253 IS A SAFE, POTENT, AND DRUGGABLE ABCA1 AGONIST. ATI'S PRECLINICAL DATA IN CELL SYSTEMS AND TWO DIFFERENT APOE4 TRANSGENIC MICE MODELS HAVE DEMONSTRATED THAT CS6253 ENGAGES ABCA1 AS A TARGET, IMPROVES APOE LIPIDATION, PREVENTS HIPPOCAMPAL AMYLOID-SS (ASS) PATHOPHYSIOLOGY, AND IMPROVES COGNITION. IN IND-ENABLING STUDIES, WHICH SHOWED EXCELLENT SAFETY AND PHARMACOKINETICS PROPERTIES, IT WAS DEMONSTRATED THAT IN PRIMATES, CS6253 TREATMENT OVER 9 DAYS SHOWED PRONOUNCED DOSE-RESPONSE REDUCTIONS IN CEREBROSPINAL FLUID (CSF) CONCENTRATIONS OF ASS42, ASS40, AND APP, AND OTHER MARKERS. THESE DATA STRONGLY SUPPORT AND EXTEND OUR EFFICACY RESULTS IN MICE PHARMACOLOGY MODELS AND ARE PREDICTIVE OF EFFICACY IN HUMANS. THUS, WITH THIS SBIR PROPOSAL, WE WILL ADVANCE CS6253 INTO EARLY CLINICAL TRIALS. IN AIM 1, ATI WILL ESTABLISH QUALIFYING METHODS FOR GMP DRUG PRODUCT AND STABILITY AT -20C FOR COFA AND RELEASE FOR PHASE 1 CLINICAL TRIAL MATERIAL. GMP DRUG PRODUCT WILL COMPLETE THE CMC SECTION (GMP DRUG SUBSTANCE IS ALREADY PRODUCED) WHICH WILL BE ADDED TO THE CLINICAL AND NONCLINICAL SECTIONS OF THE IND, FOR SUBMITTING THE IND. THE AIM 1 MILESTONE IS TO OPEN THE IND, I.E. RECEIVE FDA BUY-IN FOR INITIATING THE CS6253 PHASE 1 TRIAL. WE ARE CONFIDENT OF A SUCCESSFUL IND BASED ON THE AUGUST 2020 PRE-IND MEETING WITH FDA WHERE CONSENSUS WAS REACHED REGARDING KEY ASPECTS OF THE PROGRAM INCLUDING CMC, NONCLINICAL AND THE INITIAL CLINICAL TRIALS. IN AIM 2, WE WILL PERFORM A RANDOMIZED DOUBLE BLIND PLACEBO CONTROLLED SINGLE ASCENDING DOSE TRIAL IN HEALTHY 50-70 Y.O. MEN AND WOMEN (N=8/COHORT, 6 ACTIVE: 2 PLACEBO, TOTAL N=32) WHO WILL BE CHARACTERIZED BUT NOT STRATIFIED FOR APOE ISOFORM. PARTICIPANTS WILL RECEIVE A SINGLE INTRAVENOUS (IV) ADMINISTRATION OF CS6253 AT 4 SINGLE ASCENDING DOSES. OUR AIM 2 MILESTONE IS TO ESTABLISH SAFETY AND PHARMACOKINETICS (PLASMA AND CSF) IN HUMANS AND A SAFE STARTING DOSE FOR THE MULTIPLE ASCENDING DOSE (MAD) STUDY. WE WILL ALSO EXPLORE TRANSIENT EFFECTS ON LIPIDS AND AD BIOMARKERS BY CS6253 INCLUDING TEMPORAL PLASMA – CSF DYNAMICS OF APOLIPOPROTEINS AND AD MARKERS. THIS PROJECT WILL DETERMINE CS6253'S PHARMACOKINETICS (PLASMA AND CSF) AND SINGLE DOSE SAFETY, AND PREPARE FOR PHASE 1 MAD STUDIES OF UP TO 30 DAYS. OVERALL, CS6253 IS AN EXTREMELY PROMISING ABCA1 TARGETING NOVEL THERAPY WITH POTENTIAL TO ADDRESS APOE4 ASSOCIATED DEMENTIA INCLUDING AD.
Department of Education
$3M
EXPANDING SUCCESS FOR NYC CHILDREN
Department of State
$2.9M
INCREASE PUBLIC CONFIDENCE IN THE FORMAL JUSTICE SYSTEM THROUGH OUTREACH
Department of Education
$2.9M
EARLY READING FIRST
Department of Education
$2.9M
ESCUELA DE ARTES PLASTICAS Y DISENO USDE TITLE V
Department of Health and Human Services
$2.9M
CS6253 DEVELOPMENT FOR THE TREATMENT OF APOE4 DRIVEN DEMENTIA INCLUDINGALZHEIMER'S DISEASE
Department of Energy
$2.9M
TAS::89 0321::TAS NEW CONGRESSIONALLY DIRECTED GRANT TO THE CHARTER TOWNSHIP OF YPSILANTI FOR A PROJECT ENTITLED "ENERGY EFFICIENCY UPGRADES FOR THE
Department of Education
$2.8M
THE NEW YORK CITY CHARTER SCHOOL CONSORTIUM TO ....
Department of Education
$2.8M
GREAT OAKS LEGACY CHARTER SCHOOL: EXPANDING HIGH-QUALITY SEATS IN NEWARK, NEW JERSEY
Department of Education
$2.7M
SCHOOL CLIMATE TRANSFORMATION GRANTS TO LEAS
Department of Education
$2.7M
IMPACT AID PROGRAM, TITLE VII, SECTION 7003
Department of Energy
$2.7M
SOLAR3.0 A NATIONAL PLATFORM FOR PROCESS INNOVATION
Department of Education
$2.7M
TRI-STATE ALLIANCE FOR IMPROVING DISTRICT-LED CHARTER AUTHORIZING
Agency for International Development
$2.6M
ADVANCING WOMEN'S RIGHT OF ACCESS TO INFORMATION IN BANGLADESH (AWRTI) ACTIVITY.
Department of Health and Human Services
$2.6M
CS6253 SEQUENTIAL SUBCUTANEOUS PHARMACOKINETIC STUDY FOLLOWED BY PHASE 2A PLACEBO-CONTROLLED TRIAL WITH THREE FIXED DOSES IN APOE4 MCI AND AD PATIENTS TO ASSESS SAFETY, PK, AND BIOMARKER EFFECTS - PROJECT SUMMARY ARTERY THERAPEUTICS, INC. (ATI) IS DEVELOPING CS6253, A HIGHLY DIFFERENTIATED, CHOLESTEROL-TRANSPORT FOCUSED TREATMENT FOR THE INDICATION OF HEREDITARY APOE4-ASSOCIATED DEMENTIA INCLUDING MCI-AD, TARGETING THE ATP- BINDING-CASSETTE-TRANSPORTER A1 (ABCA1). WE NOW PROPOSE TWO SEQUENTIAL CS6253 STUDIES TO DELINEATE MECHANISM AND SHOW PROOF OF CONCEPT (POC) IN HOMOZYGOUS APOE4 EARLY AD PATIENTS. IN THE RECENTLY PERFORMED PHASE 1 SAD-MAD STUDY IN HEALTHY MEN AND WOMEN CS6253 SHOWED FAVORABLE SAFETY/TOLERABILITY AND PHARMACOKINETICS (PK), APOE TARGET ENGAGEMENT AND AN AMYLOID-CLEARANCE SIGNAL CONSISTENT WITH PREVIOUS MOUSE MODEL (BOEHM, 2016) AND PRIMATE (NOVEIR, 2022) STUDIES. IN THE PHASE 1 STUDY WE ALSO PERFORMED AN EXPLORATORY IV-SC BIOEQUIVALENCE SUB-STUDY SHOWING THAT A SINGLE CS6253 SC BOLUS INJECTION OF 1 MG/KG WAS SAFE WITH A 79% BIOAVAILABILITY (COMPARED TO IV INJECTION) AND WITHIN THE EXPOSURE RANGE OF THE SUCCESSFUL TARGETED REPLACEMENT MICE STUDIES (BOEHM, 2016). WE NOW NEED TO SHOW THAT MULTIPLE-FOLD HIGHER EXPOSURE LEVELS CAN BE REACHED BY SC ROUTE OF ADMINISTRATION PRIOR TO COMMENCING PHASE 2A MECHANISM/PROOF OF CONCEPT (POC) STUDIES, COVERING A WIDER EXPOSURE RANGE, TO EVALUATE SAFETY, PK, AND PHARMACODYNAMICS (PD) EFFECTS. THUS, OUR OBJECTIVES ARE TO PERFORM A SUBCUTANEOUS (SC) INJECTION PK FEASIBILITY STUDY WITH THE ABCA1 AGONIST CS6253, AND PROVIDED PRESPECIFIED DRUG EXPOSURE SUCCESS CRITERIA ARE MET, THEN PERFORM A 28-DAY PHASE 2A MECHANISM/POC STUDY IN 48 APOE4-CARRIERS WITH MILD COGNITIVE IMPAIRMENT (MCI), OF WHICH HALF ARE HOMOZYGOUS, TO ASSESS SAFETY, TOLERANCE, PK, PLASMA AND CSF BIOMARKER EFFECTS. WE WILL ASSESS; 1) CS6253’S ABCA1 TARGET ENGAGEMENT BY FOLLOWING CHANGE IN CSF AND PLASMA APOE (TOTAL AND ISOMER SPECIFIC PROTEIN AND GLYCOSYLATION LEVELS) AND LIPIDATION (PRIMARY EFFECT); 2) TEST AMYLOID-CLEARANCE HYPOTHESIS BY FOLLOWING CSF AND PLASMA AΒ42, AΒ40, AΒ42/40-RATIO (SECONDARY); 3) ABCA1 CHOLESTEROL-TRANSPORT SALUTARY EFFECTS BY FOLLOWING PLASMA AND CSF CHANGES IN P-TAU 181, 217, 231, GFAP, NFL, AND TREM2 (TERTIARY); 4) EXPLORE DIRECT VS INDIRECT CS6253 EFFECT BY ASSESSING UPREGULATION OF NATURAL ABCA1 AGONISTS AS APOE AND SMALL APOA-I PARTICLES IN PLASMA AND CSF (EXPLORATORY); 5) INFORM ON OPTIMAL DOSING-REGIMEN, PATIENT POPULATION (HOMOZYGOUS VS HETEROZYGOUS) AND POWER FOR SUBSEQUENT PHASE 2-3 STUDIES (TRIAL PREPARATORY). WITH A POSITIVE OUTCOME FROM THESE IMPORTANT STUDIES IN THE APOE4 CARRIER PATIENT POPULATION THE NEXT REGULATORY- CLINICAL DEVELOPMENT STEPS ARE TO PROPOSE BREAKTHROUGH DESIGNATION WITH THE FDA AND ASSESS CS6253 EFFECTS ON COGNITION IN A PHASE 2-3, 9 MONTH RANDOMIZED CONTROLLED TRIAL (RCT) IN HOMOZYGOUS APOE4 CARRIERS WITH AD/ADRD.
Department of Education
$2.6M
EARLY READING FIRST
Department of Education
$2.6M
IMPACT AID PROGRAM, DISCRETIONARY CONSTRUCTION PROGRAM
Department of State
$2.6M
AWARD CONDUCTS INTERNATIONAL ELECTORAL AND POLITICAL OBSERVATION TO SUPPORT A PEACEFUL DEMOCRATIC TRANSITION IN TUNISIA.
Department of Education
$2.6M
PROJECT PREVENT
Department of Education
$2.6M
CHARTER SCHOOLS - CHARTER SCHOOLS NATIONAL ACTIVITIES COMPETITION
Department of Education
$2.5M
CHARTER SCHOOLS MANAGEMENT ORGANIZATIONS
Department of Education
$2.5M
SAFE SCHOOLS/HEALTHY STUDENTS GRANTS
Department of Education
$2.5M
STRENGTHENING INSTITUTIONS - HISPANIC SERVING INSTITUTIONS
Department of Education
$2.5M
NEW YORK CITY CHARTER SCHOOL CONSORTIUM FOR MENTAL HEALTH SERVICE PROFESSIONAL DEVELOPMENT GRANT PROGRAM
Department of the Treasury
$2.5M
PURPOSE: TO PROVIDE GRANTS TO COMMUNITY DEVELOPMENT FINANCIAL INSTITUTIONS (CDFIS) FOR THE FOLLOWING PURPOSES 1) TO EXPAND LENDING, GRANT MAKING AND INVESTMENT ACTIVITIES IN LOW OR MODERATE INCOME COMMUNITIES AND TO BORROWERS THAT HAVE HISTORICALLY EXPERIENCED SIGNIFICANT UNMET CAPITAL AND FINANCIAL SERVICES NEEDS AND WERE DISPROPORTIONATELY IMPACTED BY THE COVID 19 PANDEMIC; AND 2) TO ENABLE CDFIS TO BUILD ORGANIZATIONAL CAPACITY AND ACQUIRE TECHNOLOGY, STAFF, AND OTHER TOOLS NECESSARY TO ACCOMPLISH THE ACTIVITIES UNDER A CDFI ERP AWARD. PLANNED ACTIVITIES: ELIGIBLE ACTIVITIES INCLUDE FINANCIAL PRODUCTS, FINANCIAL SERVICES, DEVELOPMENT SERVICES, GRANTS, LOAN LOSS RESERVES AND CAPITAL RESERVES THAT MAY BE USED TO MITIGATE THE IMPACT OF THE COVID 19 PANDEMIC ON UNEMPLOYMENT, CHILDCARE, HEALTHCARE, MENTAL HEALTHCARE, AFFORDABLE HOUSING, AFFORDABLE HOUSING FINANCE, SMALL BUSINESS, SMALL FARMS, BROADBAND INTERNET, AND FOOD SUFFICIENCY. IN ADDITION, TO SUPPORT CDFIS IN BUILDING THEIR CAPACITY TO RESPOND TO THE ECONOMIC IMPACT OF COVID 19, CDFI ERP AWARDS MAY BE USED FOR COMPENSATION PERSONAL SERVICES; COMPENSATION FRINGE BENEFITS; PROFESSIONAL SERVICE COSTS; TRAVEL COSTS; TRAINING AND EDUCATION COSTS; EQUIPMENT; SUPPLIES. END GOALS: EXPANDED FINANCING FOR LOW TO MODERATE INCOME COMMUNITIES AND INDIVIDUALS THAT HAVE HISTORICALLY EXPERIENCED SIGNIFICANT UNMET CAPITAL AND FINANCIAL SERVICES NEEDS AND WERE DISPROPORTIONATELY IMPACTED BY THE COVID 19 PANDEMIC INCLUDING SPECIFIC DESIGNATED COVID IMPACTED CDFI ERP ELIGIBLE GEOGRAPHIES AS AREAS THAT MAY BENEFIT FROM CDFI ERP ASSISTANCE. BENEFICIARIES: CERTIFIED CDFIS WHICH MAY BE FOR PROFIT ORGANIZATION, PRIVATE NONPROFIT INSTITUTION/ORGANIZATION, AND OTHER PRIVATE INSTITUTION/ORGANIZATION, AS DEFINED IN 12 C.F.R. 1805, AND LOW AND MODERATE INCOME INDIVIDUALS AND FAMILIES. SUBRECIPIENTS: THERE ARE NO SUBRECIPIENTS FOR THIS PROGRAM. BROADBAND: SPECIFIC ACTIVITIES RELATING TO BROADBAND USAGE ARE NOT KNOWN AT THE TIME OF AWARD. REASON/PURPOSE OF MODIFICATION: NOT APPLICABLE.
Department of the Treasury
$2.5M
PURPOSE: TO PROVIDE GRANTS TO COMMUNITY DEVELOPMENT FINANCIAL INSTITUTIONS (CDFIS) FOR THE FOLLOWING PURPOSES 1) TO EXPAND LENDING, GRANT MAKING AND INVESTMENT ACTIVITIES IN LOW OR MODERATE INCOME COMMUNITIES AND TO BORROWERS THAT HAVE HISTORICALLY EXPERIENCED SIGNIFICANT UNMET CAPITAL AND FINANCIAL SERVICES NEEDS AND WERE DISPROPORTIONATELY IMPACTED BY THE COVID 19 PANDEMIC; AND 2) TO ENABLE CDFIS TO BUILD ORGANIZATIONAL CAPACITY AND ACQUIRE TECHNOLOGY, STAFF, AND OTHER TOOLS NECESSARY TO ACCOMPLISH THE ACTIVITIES UNDER A CDFI ERP AWARD. PLANNED ACTIVITIES: ELIGIBLE ACTIVITIES INCLUDE FINANCIAL PRODUCTS, FINANCIAL SERVICES, DEVELOPMENT SERVICES, GRANTS, LOAN LOSS RESERVES AND CAPITAL RESERVES THAT MAY BE USED TO MITIGATE THE IMPACT OF THE COVID 19 PANDEMIC ON UNEMPLOYMENT, CHILDCARE, HEALTHCARE, MENTAL HEALTHCARE, AFFORDABLE HOUSING, AFFORDABLE HOUSING FINANCE, SMALL BUSINESS, SMALL FARMS, BROADBAND INTERNET, AND FOOD SUFFICIENCY. IN ADDITION, TO SUPPORT CDFIS IN BUILDING THEIR CAPACITY TO RESPOND TO THE ECONOMIC IMPACT OF COVID 19, CDFI ERP AWARDS MAY BE USED FOR COMPENSATION PERSONAL SERVICES; COMPENSATION FRINGE BENEFITS; PROFESSIONAL SERVICE COSTS; TRAVEL COSTS; TRAINING AND EDUCATION COSTS; EQUIPMENT; SUPPLIES. END GOALS: EXPANDED FINANCING FOR LOW TO MODERATE INCOME COMMUNITIES AND INDIVIDUALS THAT HAVE HISTORICALLY EXPERIENCED SIGNIFICANT UNMET CAPITAL AND FINANCIAL SERVICES NEEDS AND WERE DISPROPORTIONATELY IMPACTED BY THE COVID 19 PANDEMIC INCLUDING SPECIFIC DESIGNATED COVID IMPACTED CDFI ERP ELIGIBLE GEOGRAPHIES AS AREAS THAT MAY BENEFIT FROM CDFI ERP ASSISTANCE. BENEFICIARIES: CERTIFIED CDFIS WHICH MAY BE FOR PROFIT ORGANIZATION, PRIVATE NONPROFIT INSTITUTION/ORGANIZATION, AND OTHER PRIVATE INSTITUTION/ORGANIZATION, AS DEFINED IN 12 C.F.R. 1805, AND LOW AND MODERATE INCOME INDIVIDUALS AND FAMILIES. SUBRECIPIENTS: THERE ARE NO SUBRECIPIENTS FOR THIS PROGRAM. BROADBAND: SPECIFIC ACTIVITIES RELATING TO BROADBAND USAGE ARE NOT KNOWN AT THE TIME OF AWARD. REASON/PURPOSE OF MODIFICATION: NOT APPLICABLE.
Department of Health and Human Services
$2.5M
THERAPEUTIC POTENTIAL OF EX VIVO EXPANDED HUMAN CORD BLOOD DERIVED CD133+ CELLS I
Department of Education
$2.5M
STUDENT EMERGENCY RELIEF
Department of Health and Human Services
$2.5M
MANUFACTURING OF ABCA1 AGONIST SMALL MOLECULE PEPTIDE CS6253 TO SUPPORT CHRONIC TOXICOLOGY STUDIES IN WISTAR RATS AND CYNOMOLGUS MONKEYS - PROJECT SUMMARY THE PRIMARY AIM OF THIS PROPOSAL IS TO MANUFACTURE THE ABCA1 AGONIST SMALL MOLECULE PEPTIDE CS6253 FOR UPCOMING CHRONIC TOXICOLOGY STUDIES (OUTSIDE OF THIS GRANT SCOPE) IN WISTAR RATS AND CYNOMOLGUS MONKEYS. FOLLOWING THIS, ARTERY THERAPEUTICS, INC. (ATI) PLANS TO OVERSEE THE EXECUTION OF THESE STUDIES AND THEN PROVIDE THE FDA WITH THE REPORTS INCLUDING IN SEND FORMAT. THE ULTIMATE GOAL IS TO LAY THE GROUNDWORK FOR PHASE 2-3 COGNITION TRIALS LASTING 6 MONTHS OR LONGER, FOCUSING ON PATIENTS WITH MILD COGNITIVE IMPAIRMENT (MCI) AND ALZHEIMER'S DISEASE (AD). IN ADDITION TO MANUFACTURING THE MATERIAL FOR TOXICOLOGY STUDIES, THIS CAMPAIGN WILL ALSO INCLUDE LONG-TERM STABILITY TESTING. THE DATA GENERATED WILL BE UTILIZED TO UPDATE THE DRUG MASTER FILE. CS6253 HAS DEMONSTRATED ITS SAFETY, TOLERANCE AND FAVORABLE PHARMACOKINETICS (PK) IN THE CLINICAL PHASE 1 SAD-MAD-BIOEQUIVALENCE TRIAL ATI-CS-001 (GRANT 1R44AG076299, NATIONAL CLINICAL TRIAL # 05965414). FOLLOWING THESE SUCCESSFUL PHASE 1 RESULTS IT IS IMPERATIVE TO PROCEED TO COGNITION TRIALS. COGNITION TRIALS TYPICALLY SPAN 6 TO 9 MONTHS OR LONGER AND NECESSITATE A COMPREHENSIVE TOXICOLOGY PACKAGE AFFIRMING LONG-TERM SAFETY PRIOR TO TRIAL COMMENCEMENT. THE CHRONIC TOXICOLOGY STUDIES REQUIRE APPROXIMATELY 2.3 KILOGRAMS OF GOOD MANUFACTURING PRACTICES (GMP) LIKE DRUG SUBSTANCE MATERIAL. TO MEET THIS DEMAND, WE WILL ENGAGE THE SERVICES OF AMBIOPHARM, INC, OUR TRUSTED MANUFACTURER FROM PREVIOUS CS6253 DRUG SUBSTANCE CAMPAIGNS. AMBIOPHARM IS A FULL-SERVICE CONTRACT DEVELOPMENT AND MANUFACTURING ORGANIZATION (CDMO), HAS SUCCESSFULLY PRODUCED ATI'S CS6253 NON-GMP TOXICOLOGY AND GMP CLINICAL DRUG SUBSTANCES THAT SUPPORTED THE INVESTIGATIONAL NEW DRUG (IND) APPLICATION AND THE ATI-CS-001 CLINICAL TRIAL. AMBIOPHARM CURRENTLY PRODUCES COMMERCIAL PEPTIDES UP TO MULTI-KG QUANTITIES AND HAS A QUALITY ASSURANCE SYSTEM IN PLACE FOR GMP PEPTIDES FOR CLINICAL TRIALS, AS DEMONSTRATED BY THEIR WORK WITH CS6253 AT ITS CURRENT STAGE AND WITH OTHER COMMERCIAL PEPTIDE PRODUCTS. CS6253 DRUG SUBSTANCE HAS DISPLAYED 32+ MONTHS STABILITY WHEN STORED IN -20 DEGREE C CONDITION. ALSO, THE ONGOING ICH DRUG PRODUCT STABILITY TESTING SHOWS THAT CS6253 IN SOLUTION REMAINS STABLE FOR MORE THAN 9 MONTHS IN 5 DEGREE C.
Department of Defense
$2.4M
AUTOLOGOUS BONE MARROW DERIVED MONONUCLEAR CELL THERAPY FOR COMPARTMENT SYNDROME YEAR 3 AND 4.
Department of Transportation
$2.4M
CHARLESTON COUNTY ALONG WITH BERKELEY AND DORCHESTER COUNTY, PLANS TO IMPLEMENT A FULL CAD-TO-CAD (COMPUTER AIDED DISPATCH) TO ADDRESS POST-CRASH CARE IN OVERLAPPING JURISDICTIONAL AREAS BETWEEN THE CITY OF CHARLESTON AND THE CITY OF NORTH CHARLESTON AND BERKELEY AND DORCHESTER COUNTIES, RESPECTIVELY. THE IMPLEMENTATION OF THE CAD-TO-CAD CONNECTION IS A DEMONSTRATION ACTIVITY CONNECTED TO THE BERKELEY, CHARLESTON, DORCHESTER COUNCIL OF GOVERNMENT (BCDCOG) SAFETY ACTION PLAN.
Department of Education
$2.4M
STRENGTHENING CHARTER AUTHORIZING NATIONALLY
Department of Education
$2.4M
CHARTER SCHOOLS NATIONAL ACTIVITIES COMPETITION
Department of Education
$2.4M
ADDRESSING BOTH SIDES OF CHARTER QUALITY: IMPROVING AUTHORIZING PRACTICE + GROWING QUALITY CHARTER ORGANIZATIONS THROUGH THE DISSEMINATION OF FRAMEWORKS & SUPPORTS
Department of Education
$2.4M
FACILITATING CHARTER SCHOOLS: A PROPOSAL TO CREATE A CHARTER SCHOOL FACILITY CENTER AT THE NATIONAL ALLIANCE FOR PUBLIC CHARTER SCHOOLS
Department of Education
$2.4M
IMPACT AID PROGRAM, TITLE VII, SECTION 7003
Agency for International Development
$2.3M
INTERNATIONAL ELECTION OBSERVATION MISSION TO KENYA S
Department of Agriculture
$2.3M
STREAMBANK <(>&<)> BED STABILIZATION/ DEBRIS REMOVAL FOR DSRS 47-01-24-5133-412THRU422 <(>&<)> 424, 52 SITES IN CARTER COUNTY, TN (S EPTEMBER 2024 HURRICANE HELENE).
Department of Education
$2.3M
CHARTER SCHOOLS NATIONAL ACTIVITIES COMPETITION
Department of State
$2.3M
TUNISIAN CONSTITUENT ASSEMBLY ELECTION OBSERVATION
Agency for International Development
$2.3M
OBSERVING THE 2022 REFERENDUM AND PARLIAMENTARY ELECTIONS IN TUNISIA
Agency for International Development
$2.3M
ADVANCING WOMEN'S RIGHT OF ACCESS TO INFORMATION IN BANGLADESH
Department of Education
$2.2M
ESCUELA DE ARTES PLÁSTICAS Y DISEÑO DE PUERTO RICO EMERGENCY RELIEF FUND - INSTITUTIONAL PORTION
Agency for International Development
$2.2M
MITIGATING ELECTRCAL VIOLENCE THROUGH NATIONAL EARLY WARNING SYSTEMS (NEWS)
Department of Education
$2.2M
HEBREW PUBLIC SUPPORTING, REWARDING, AND GROWING EDUCATORS (HP SURGE)
Department of Education
$2.2M
HYDE LEADERHSUIP CHARTER SCHOOL-BROOKLYN INNOVATIVE APPROACHES TO LITERACY
Department of Health and Human Services
$2.2M
STRENGTHENING GLOBAL HEALTH SECURITY THROUGH SURVEILLANCE, PREVENTION, AND RESPONSE WITH A FOCUS ON STRENGTHENING DATA AND HEALTH INFORMATION SYSTEMS - SEE ATTACHMENT
Department of Housing and Urban Development
$2.1M
NEIGHBORHOOD STABILIZATION PRG
Department of Education
$2.1M
FRIENDSHIP SEEKS TO REPLICATE ITS HIGH SCHOOL CLUSTER MODEL OF FEEDER SCHOOLS FROM ITS NETWORK. ARMSTRONG, IDEAL AND WOODRIDGE WILL BE FEEDER SCHOOLS FOR THE FUTURE FRIENDSHIP COLLEGIATE WEST.
Department of Education
$2.1M
A PROPOSAL TO CREATE THE CHARTER SCHOOL COLLABORATIVE TO ACCELERATE STUDENT LEARNING IN RESPONSE TO THE COVID-19 PANDEMIC
Department of Education
$2.1M
HYDE LEADERSHIP CHARTER SCHOOL-BROOKLYN SUPPORTING POSITIVE, ASPIRATIONAL, AND RESPONSIBLE KIDS (SPARK)
Department of Education
$2.1M
ENRICH - ENGAGING NEW READERS IN A COMMUNITY OF HIGH-NEED
Department of Education
$2M
CHARTER SCHOOLS MANAGEMENT ORGANIZATIONS
Department of Veterans Affairs
$2M
VA IS PROVIDING PER DIEM FUNDING TO ASSIST WITH THE OPERATIONAL COSTS ASSOCIATED WITH TRANSITIONAL HOUSING BEDS FOR HOMELESS VETERANS.
Department of Education
$2M
EDUCATING FOR EXCELLENCE: CREATING AND SUSTAINING DIVERSE AND EFFECTIVE CHARTER SCHOOL LEADERSHIP THROUGH THE DISSEMINATION OF PROGRAMS & SUPPORTS
Department of Education
$2M
CHARTER SCHOOLS NATIONAL ACTIVITIES COMPETITION
Department of Education
$2M
CAROL M. WHITE PHYSICAL EDUCATION PROGRAM
Department of Housing and Urban Development
$2M
NEIGHBORHOOD STABILIZATION PRG
Department of Education
$2M
FULL SERVICE COMMUNITY SCHOOLS PROGRAM
Department of Housing and Urban Development
$2M
ECONOMIC DEVELOPMENT INITIATIVE, COMMUNITY PROJECT FUNDING, AND MISCELLANEOUS GRANTS
Department of Commerce
$2M
THIS EDA INVESTMENT SUPPORTS THE CHARTER TOWNSHIP OF MUNDY WITH UPGRADING THE CRITICAL WATER AND ROAD INFRASTRUCTURE TO SERVE INDUSTRIAL USERS' REQUIREMENTS FOR WATER PRESSURE AND TRUCK ACCESS IN GENESEE COUNTY, MICHIGAN. THE PROJECT WORK INCLUDES UPGRADING APPROXIMATELY 800 FEET OF SANITARY SEWER, 9500 FEET OF WATER MAIN, 3175 FEET OF STORM SEWER, DRAIN EXTENSIONS AND DETENTION AREAS. ONCE COMPLETED, THE PROJECT WILL SUPPORT EXISTING MANUFACTURING BUSINESSES, ATTRACT NEW PRIVATE INVESTMENT, AND CREATE JOBS IN HEALTHCARE, MANUFACTURING, AND TECHNOLOGY SECTORS.
Department of the Treasury
$2M
FINANCIAL ASSISTANCE AWARD
Department of the Treasury
$2M
FINANCIAL ASSISTANCE AWARD
Department of Commerce
$2M
WATER TREATMENT PLANT
Agency for International Development
$2M
THE GRANTEE WILL DEPLOY A LONG-TERM ELECTION OBSERVATION MISSION TO ASSESS TUNISIA¿S PARLIAMENTARY AND PRESIDENTIAL ELECTIONS. RIGOROUS INDEPENDENT OBSERVATION ACTIVITIES, PAIRED WITH PRIVATE ADVOCACY AND PUBLIC REPORTING, SERVE TO SUPPORT TUNISIA¿S ELECTORAL AUTHORITIES WITH TIMELY, CONSTRUCTIVE RECOMMENDATIONS WHILE INCREASING TRANSPARENCY OF AND PUBLIC CONFIDENCE IN THE POLLS AND TABULATION PROCESSES.
Department of Health and Human Services
$2M
PHASE 1/2A CLINICAL STUDY OF DESCARTES-30 IN ACUTE RESPIRATORY DISTRESS SYNDROME - ABSTRACT THIS APPLICATION IS TO SUPPORT A CLINICAL TRIAL OF THE FIRST MRNA ENGINEERED CELL THERAPY FOR ACUTE RESPIRATORY DISTRESS SYNDROME (ARDS), INCLUDING ARDS CAUSED BY COVID-19. THE FDA HAS ALREADY REVIEWED THE IND APPLICATION AND DETERMINED THAT THE STUDY MAY PROCEED. ARDS IS A SEVERE INFLAMMATORY RESPIRATORY FAILURE THAT KILLS AN ESTIMATED 80,000 AMERICANS EACH YEAR. 80% OF ARDS PATIENTS REQUIRE MECHANICAL VENTILATION. NO FDA-APPROVED THERAPIES FOR ARDS ARE AVAILABLE. ARDS MAY RESULT FROM INFECTIOUS OR NON-INFECTIOUS (E.G., TRAUMATIC OR CHEMICAL) INSULTS. COVID-19 IS CURRENTLY THE MOST COMMON CAUSE OF ARDS, AND THE VAST MAJORITY OF COVID-19 DEATHS ARE DUE TO ARDS. NEUTROPHIL EXTRACELLULAR TRAPS (NETS) DRIVE THE HYPERACTIVE INFLAMMATORY RESPONSE IN ARDS AND COVID-19, AND PRESENCE OF NETS CORRELATES STRONGLY WITH ARDS SEVERITY. NETS ARE PRODUCED BY LOCALLY-TRAFFICKED NEUTROPHILS UNDERGOING NETOSIS, A PROGRAMMED CELL DEATH WHERE THE CELLS LYSE TO SECRETE DNA DECORATED WITH INFLAMMATORY PROTEINS. LOW AMOUNTS OF NETS ARE THOUGHT TO HELP ENTRAP INFECTION, BUT HYPERACTIVATED NEUTROPHILS PRODUCE LARGE QUANTITIES OF NETS THAT CAUSE HYPOXIA AND IMMUNE THROMBI DUE TO PHYSICAL BLOCKADE OF ALVEOLI AND MICROVASCULATURE. A NET-DEGRADING THERAPY THEREFORE WOULD BE A SIGNIFICANT ADVANCE IN TREATMENT OF ARDS. DESCARTES-30 IS THE FIRST ALLOGENEIC (I.E., OFF-THE-SHELF) ENGINEERED HUMAN MESENCHYMAL STEM CELL (MSC) THERAPY SECRETING A COMBINATION OF TWO POTENT NET-DEGRADING ENZYMES. IN THIS PHASE 1/2A STUDY, THE HYPOTHESIS TO BE TESTED IS THAT DESCARTES-30 WILL BE WELL TOLERATED AND SHOW EVIDENCE OF EFFICACY IN PATIENTS WITH MODERATE TO SEVERE ARDS AND COVID- 19. AIMS ARE TO DETERMINE THE MAXIMUM TOLERATED DOSE AND EVIDENCE OF PRELIMINARY EFFICACY, DEFINE PHARMACOKINETIC PROPERTIES AND BIOLOGIC CORRELATES OF DISEASE, AND ESTABLISH A VALIDATED POTENCY ASSAY FOR USE IN LATER-STAGE CLINICAL DEVELOPMENT. THESE DATA WILL INFORM THE DESIGN OF A CONTROLLED REGISTRATION STUDY IN PATIENTS WITH MODERATE-TO-SEVERE ARDS.
Department of Health and Human Services
$2M
AUTOLOGOUS T-CELLS EXPRESSING A CHIMERIC ANTIGEN RECEPTOR DIRECTED TO B-CELL MATURATION ANTIGEN (BCMA) IN PATIENTS WITH GENERALIZED MYASTHENIA GRAVIS (MG)
Department of Health and Human Services
$2M
PHASE 1/2 CLINICAL STUDY OF HUMANIZED ANTI-BCMA CAR T CELLS IN RELAPSED/REFRACTORY MULTIPLE MYELOMA (MM)
Department of Education
$2M
CHARTER SCHOOLS NATIONAL ACTIVITIES COMPETITION
Source: Federal Audit Clearinghouse (fac.gov)
No federal single audit records found for this organization.
Single audits are required for entities expending $750,000+ in federal awards annually.
Source: IRS e-Filed Form 990
No officer or director compensation data available for this organization.
This data is sourced from IRS Form 990, Part VII. It may not be available if the organization files Form 990-N (e-Postcard) or has not yet been enriched.
Source: IRS Publication 78, Auto-Revocation List & e-Postcard Data
Tax-deductible contributions: Yes
Deductibility code: PC
Sources: IRS e-Filed Form 990 (XML) & ProPublica Nonprofit Explorer
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| Year | Revenue | Contributions | Expenses | Assets | Net Assets |
|---|---|---|---|---|---|
| 2023 | $257.8K | $157.9K | $213.1K | $398.6K | $395.6K |
| 2022 | $266.6K | $165.8K | $169.6K | $353.6K | $350.8K |
| 2021 | $281.6K | $173.4K | $203.1K | $258.2K | $253.9K |
| 2020 | $152.1K | — | $127.5K | $200.3K |
Sources: ProPublica Nonprofit Explorer & IRS e-File Index
| Tax Year | Form Type | Source | Documents |
|---|---|---|---|
| 2024 | 990 | IRS e-File | PDF not yet published by IRSView Filing → |
| 2023 | 990 | DataIRS e-File | PDF not yet published by IRSView Filing → |
| 2022 | 990 | DataIRS e-File |
Financial data: IRS Form 990 via ProPublica Nonprofit Explorer (Tax Year 2023)
Federal grants: USAspending.gov (live)
Organization info: IRS Business Master File · ProPublica Nonprofit Explorer
Tax-deductibility: IRS Publication 78
| — |
| 2019 | $207.1K | $133.3K | $191.5K | $151.7K | $150.9K |
| 2018 | $344.7K | $228.9K | $293.4K | $135.5K | $135.3K |
| 2017 | $99.6K | $99.6K | $146.6K | $93.4K | $84K |
| 2016 | $259.9K | $231.3K | $255.2K | $134.6K | $131K |
| 2015 | $128K | — | $111.4K | $185.4K | — |
| 2014 | $104.5K | — | $102.8K | $116.1K | — |
| 2013 | $130K | — | $108.6K | $107.9K | — |
| 2012 | $73.6K | — | $113K | $86.6K | — |
| 2011 | $120.9K | — | $79.3K | $126.1K | — |
| 2021 | 990 | Data | PDF not yet published by IRS |
| 2020 | 990-EZ | Data |
| 2019 | 990 | Data |
| 2018 | 990 | Data |
| 2017 | 990 | Data |
| 2016 | 990 | Data |
| 2015 | 990-EZ | Data |
| 2014 | 990-EZ | Data |
| 2013 | 990-EZ | Data |
| 2012 | 990-EZ | Data |
| 2011 | 990-EZ | Data |
| 2010 | 990-EZ | — |
| 2009 | 990 | — |
| 2008 | 990 | — |
| 2007 | 990 | — |
| 2006 | 990 | — |
| 2005 | 990 | — |
| 2004 | 990 | — |