Research Triangle Institute

GH/HIDN/ID 936-3100 AAD

HIGH TEMPERATURE SYNGAS CLEANUP TECHNOLOGY SCALE-UP AND DEMONSTRATION PROJECT

TO ADDRESS CHALLENGES AND GAPS, RTI¿S SUSTAIN TEAM HAS DESIGNED A CAPACITY STRENGTHENING FOR SUSTAINABILITY APPROACH FOR CEP-NTD ELEMENT 2. THROUGH SEVEN IMPLEMENTATION STRATEGIES, SUSTAIN WILL SUPPORT COUNTRIES TO ACCELERATE PROGRESS NOW; ADDRESS BARRIERS WITH INNOVATION; DOCUMENT AND SHARE SUCCESSES; IDENTIFY LONG-TERM CONTROL PLATFORMS; AND STRENGTHEN LOCAL CAPACITY FOR PLANNING, BUDGETING, AND DELIVERY SO THAT NTD PROGRAMS CAN CONTINUE WITH HIGH LEVELS OF EFFECTIVENESS. SUSTAIN EXPERTS AND COUNTRY TEAMS WILL TAILOR THIS CAPACITY STRENGTHENING APPROACH AND STRATEGIES THROUGH REGULAR COMMUNICATION WITH USAID¿S NTD STAFF AND MINISTRIES OF HEALTH (MOHS). DATA AND CONTEXT WILL BE INCREASINGLY IMPORTANT AT THE COUNTRY LEVEL AS ELIMINATION APPROACHES; COVERAGE CHALLENGES IN THE LAST ENDEMIC AREAS ARE UNIQUE, REQUIRING INNOVATIVE STRATEGIES BASED ON ACCURATE DATA IN A SPECIFIC CONTEXT.

DESCRIPTION:RESEARCH TRIANGLE INSTITUTE (RTI) WILL UTILIZE THE SUBSEQUENT AWARD TOTALING $95,000,000 IN EJ TCGM FUNDING TO SERVE AS ONE OF ELEVEN GRANTMAKER ORGANIZATIONS THAT ARE CHARGED WITH IMPLEMENTING THE PROGRAM. RTI WILL SERVE IN THE CAPACITY OF A NATIONAL GRANTMAKER (CENTRAL REGIONS) AS WELL AS THE PROVISION OF DIRECT ASSISTANCE TO REGIONS 4 AND REGION 7. RTI WILL IMPLEMENT AND DEPLOY FEDERAL FINANCIAL ASSISTANCE TO INSTILL RESILIENCE TO UNDERSERVED COMMUNITIES INCLUSIVE OF REGIONS 4, 5, 6 AND 7. THIS FUNDING IS THE LATTER HALF OF THE BIFURCATED AWARD THAT WILL BE USED FOR PASSTHROUGH GRANTMAKING ACTIVITIES AUTHORIZED UNDER CAA 138(B). THE RTI NATIONAL GRANTMAKER (CENTRAL REGIONS) WILL BE FUNDED BY THE INFLATION REDUCTION ACT (IRA) APPROPRIATIONS AT THE LEVEL TOTALING $120 MILLION AND DIVIDED INTO TWO AWARDS. THE INITIAL AWARD OF $25 MILLION WAS MADE IN AUGUST 2024 AND THE SUBSEQUENT AWARD OF $95 MILLION IS SLATED FOR DECEMBER 2024. THE BIFURCATED AWARD IS SOURCED FROM THE SAME FUNDING BUT WILL MAINTAIN SEPARATE BUT OVERLAPPING TIMELINES TO MEET THE OVERALL COMPONENTS OF THE AWARD. THE SUBSEQUENT AWARD INCLUDES AWARD COMPETITION, SELECTION AND DISTRIBUTION OF FUNDS, CAPACITY BUILDING AND TECHNICAL ASSISTANCE FOR REGIONAL GRANTMAKERS AND SUBRECIPIENTS, PARTICIPATORY GOVERNANCE AND OUTREACH EFFORTS THAT WILL SUPPORT THE REGIONAL GRANTMAKERS IN 4,5,6, AND 7 AS WELL AS ADDRESSING COVERAGE GAPS THAT THEY MAY HAVE DIFFICULTY REACHING. GAPS INCLUDE, BUT IS NOT LIMITED TO, REMOTE AND/OR RURAL AREAS OF THE U.S. TERRITORIES AND PARTS OF THE CONTIGUOUS UNITED STATES. OEJECR HAS ALSO PROVIDED ADDITIONAL WITHIN-SCOPE SUPPLEMENTAL FUNDING FOR EACH GRANTMAKER TO ADDRESS QUALITY ASSURANCE (QA), HUMAN SUBJECTS REVIEW (HSR), AS WELL AS PROVIDE FUNDING FOR ADDITIONAL MEANINGFUL OUTREACH AND GAP FILLING TO REMOTE, RURAL AND HARD-TO-REACH AREAS OF THE COUNTRY, AND TERRITORIES THAT MUST BE ADJUSTED DUE TO ELEVATED TRAVEL COSTS. SUPPLEMENTAL FUNDS TOTAL $20M OF THE $95 MILLION AND WILL BE USED TO SUPPORT THE SUCCESSFUL DISTRIBUTION AND COMPLETION PROJECTS FUNDED UNDER THE SUBAWARDS. IT SHOULD BE NOTED THAT THE INITIAL AWARD ENABLED THE GRANTMAKER TO PERFORM THE TASKS NEEDED TO PLAN AND IMPLEMENT PROPOSED PARTICIPATORY GOVERNANCE, OUTREACH, AND SYSTEM MOBILIZATION EFFORTS THAT ESTABLISHED THE CRITERIA FOR THE COLLECTION, REVIEW, SELECTION, AND DISTRIBUTION OF THE EJ THRIVING COMMUNITIES SUBAWARDS. THE PASS-THROUGH MODEL DEVELOPED BY EPA IS CENTRAL TO THE NEW APPROACH, AS IT ALLOWS THE GRANTMAKERS TO DISTRIBUTE SMALLER SUBAWARDS TO COMMUNITY-BASED ORGANIZATIONS (CBOS) MORE EFFICIENTLY THAN THE TRADITIONAL FEDERAL GRANTS PROCESS. THIS MODEL WILL ENDEAVOR TO ENSURE THAT UNDERSERVED COMMUNITIES CAN ACCESS FUNDS MORE QUICKLY AND WITH FEWER ADMINISTRATIVE BURDENS. THE WORK PREVIOUSLY CONDUCTED UNDER THE ENVIRONMENTAL JUSTICE SMALL GRANTS PROGRAM WILL BE MANAGED BY GRANTMAKERS WHILE ALLOWING EPA TO FOCUS ON ASSESSMENT, PLANNING, AND PROJECT DEVELOPMENT. RTI HAS EXTENSIVE EXPERIENCE IN GRANTMAKING AND PROVIDING TECHNICAL SUPPORT FOR EQUITY-CENTERED APPROACHES THAT BUILD COLLABORATIVE ENVIRONMENTALLY BASED OUTCOMES AND WILL ENDEAVOR TO ENSURE THAT EPA FUNDS UNDER THE THRIVING COMMUNITY GRANTMAKER PROGRAM ARE MANAGED AND DISTRIBUTED TO COMMUNITIES THAT ARE MOST IN NEED OF ADDRESSING HEALTH AND ENVIRONMENTAL CHALLENGES. BY INCREASING FUNDING ACCESS AND REDUCING ADMINISTRATIVE BARRIERS, THE EPA AIMS TO EMPOWER DISADVANTAGED COMMUNITIES TO ADDRESS LONG-STANDING ENVIRONMENTAL JUSTICE CHALLENGES. THIS APPROACH ALIGNS WITH THE GOALS OF EXECUTIVE ORDERS 13985 AND 14008, WHICH PRIORITIZE EQUITABLE ACCESS TO FEDERAL RESOURCES AND EMPHASIZES THE NEED FOR INCLUSIVE DECISION-MAKING PROCESSES THAT ADVANCE ENVIRONMENTAL JUSTICE NATIONWIDE. ACTIVITIES:AS IT RELATES TO EPA REGION 4, RTI WILL PARTNER WITH THE SOUTHERN ENVIRONMENTAL LAW CENTER (SELC), NATIONAL CENTER FOR HEALTHY HOUSING, INTERNATIONAL CITY/COUNTY HOUSING, INTERNATIONAL CITY/COUNTY MAN

THIS IS A FIVE YEARS COOPERATIVE AGREEMENTWITH A TOTAL ESTIMATED COST OF $129,828,192

DEFENSE SCIENCE, TECHNOLOGY, ENGINEERING, AND MATHEMATICS (STEM) EDUCATION CONSORTIUM

THE PURPOSE OF THIS MODIFICATION IS TO 1) PROVIDE INCREMENTAL FUNDING IN THE AMOUNT OF $14,850,000.00, INCREASING THE AMOUNT OBLIGATED FROM $13,000,0

DATA COORDINATING CENTER FOR THE NICHD NEONATAL RESEARCH NETWORK (U24)

USAID EARLY GRADE READING AND MATH PROJECT

KENYA FEED THE FUTURE CROPS AND DAIRY MARKET SYSTEMS DEVELOPMENT ACTIVITY

UGANDA LITERACY AND HEALTH EDUCATION PROGRAM

THE PURPOSE OF THIS AWARD IS TO PROVIDE SUPPORT FOR A 5-YEAR PROGRAM ENTITLED "FAMILY PLANNING/MATERNAL & NEONATAL HEALTH INNOVATIONS AND CAPACITY BUILDING PLATFORM (REACHHEALTH)."

QUALITY INSTRUCTION TOWARDS BASIC EDUCATION IMPROVEMENT AND ACCESS 3 ACTIVITY (QITABI 3)

READING FOR ETHIOPIA''S ACHIEVEMENT DEVELOPED (READ) TECHNICAL ASSISTANCE

DATA COORDINATING CENTER FOR THE NICHD COOPERATIVE MULTICENTER NEONATAL RESEARCH

IDH WILL SUPPORT THE IMPLEMENTATION OF COMPREHENSIVE HEALTH PLANS AT THE DISTRICT LEVEL THAT ADDRESS THE KEY DRIVERS OF MALARIA, MATERNAL, NEONATAL, AND CHILD MORBIDITY AND MORTALITY IN FIVE PRIORITY REGIONS OF SENEGAL TO IMPROVE THE HEALTH STATUS OF THE TARGET POPULATIONS. THE ACTIVITY COMBINES TECHNICAL ASSISTANCE FOR SERVICE DELIVERY AND UNIVERSAL HEALTH COVERAGE, SOCIAL AND BEHAVIOR CHANGE, SUBGRANT FUNDING AND HEALTH SYSTEMS STRENGTHENING INTO ONE MECHANISM.

NEW COOPERATIVE AGREEMENT AWARD TO RTI

NEW CO-OPERATIVE AGREEMENT DSEC

THE ABC+ ADVANCING BASIC EDUCATION IN THE PHILIPPINES (ABC+) PROJECT IS A FIVE-YEAR, $38.5 MILLION PROJECT TO IMPROVE BASIC LIFE SKILLS FOR CHILDREN IN THE EARLY GRADES THROUGHOUT THE PHILIPPINES. THIS INCLUDES THE ABILITY TO READ AND DO MATH, AND TO APPLY OTHER BASIC LIFE SKILLS. TO ACHIEVE ITS GOAL, THE PROJECT IS PURSUING AN INTEGRATED APPROACH TO ABC+'S THREE INTERMEDIATE RESULTS (IRS). IMPROVED INSTRUCTION AND LEARNING DELIVERY (IR1) WILL INVEST IN PROFESSIONAL DEVELOPMENT AND SUPPORT FOR TEACHERS. TO IMPROVE ACCESS TO QUALITY MATERIALS (IR2), THE PROJECT WILL INTRODUCE INNOVATIVE APPROACHES TO MATERIALS DEVELOPMENT AND BUILD CAPACITY TO DEVELOP AND MAKE AVAILABLE MATERIALS IN A VARIETY OF LANGUAGES. TO ENSURE THAT ABC+-INTRODUCED IMPROVEMENTS CAN REACH ALL SCHOOLS IN THE TARGET REGIONS AND BE SUSTAINED (IR3), THE PROJECT WILL BUILD SYSTEM CAPACITY AND DEPED COMMITMENT TO PLAN, MOBILIZE, AND MANAGE PUBLIC AND PRIVATE RESOURCES AND TO SUPPORT IMPROVED EARLY GRADE LEARNING.

TO IMPROVE THE READING SKILLS OF PRIMARY-GRADE LEARNERS IN GOVERNMENT SCHOOLS IN UGANDA THROUGH THE SCALE UP OF THE EGR METHODOLOGY

GUINEA MALARIA BILATERAL AWARD

SCIENCE TECHNOLOGY RESEARCH INNOVATION FOR DEVELOPMENT (STRIDE)

IGF::CL::IGF USAID/RENFORCEMENT DE LA LITTÉRATIE AU SENEGAL (RELIS). TO IMPROVE STUDENTS’ READING OUTCOMES IN KINDERGARTEN (KG) THROUGH SECOND GRADES IN NINE REGIONS OF SENEGAL.

KINERJA (LOCAL GOVERNANCE PROGRAM)

GUINEA LOCAL HEALTH SYSTEMS STRENGTHENING (GLHSS) ACTIVITY WILL CONTRIBUTE TO SELF-RELIANCE AND SUSTAINABILITY BY BUILDING THE CAPACITY AND COMMITMENT OF COMMUNITY HEALTH COMMITTEES TO COLLABORATE PRODUCTIVELY WITH THEIR STRENGTHENED LOCAL PUBLIC HEALTH FACILITIES. ENGENDERING GREATER TRUST OF LOCAL COMMUNITIES IN THE PUBLIC HEALTH SYSTEM WOULD RESULT IN STRONGER PARTICIPATION IN THE MANAGEMENT AND GOVERNANCE OF THE HEALTH SECTOR. INCREASED CAPACITY AND COMMITMENT OF COMMUNITY MEMBERS AND HEALTH FACILITY STAFF WOULD SUSTAIN GLHSS GAINS BEYOND THE LIFE OF THE ACTIVITY.

NUTRITION FOR PRECISION HEALTH, POWERED BY THE ALL OF US RESEARCH PROGRAM: RESEARCH COORDINATING CENTER - CONTACT PD/PI: GANTZ, MARIE G. PROJECT SUMMARY/ABSTRACT FROM PROPOSAL: THE OVERARCHING GOAL OF THE RTI INTERNATIONAL–CORNELL RESEARCH COORDINATING CENTER (RCC) IS TO PROVIDE SEAMLESS OPERATIONAL SUPPORT AND MULTIDISCIPLINARY EXPERIENCE FOR BUILDING CONSENSUS IN THE NUTRITION FOR PRECISION HEALTH CONSORTIUM (NPHC). IN THE 1-YEAR PLANNING PHASE, WE WILL PRIORITIZE EFFICIENCY AND OBJECTIVITY IN FACILITATING THE DESIGN OF DIET MODULES (1: USUAL DIETARY ASSESSMENT; 2: CONTROLLED FEEDING DIETARY INTERVENTION; AND 3: DOMICILED DIETARY INTERVENTION) NESTED IN ALL OF US AND THEIR RESEARCH PROTOCOLS. IN THE 4-YEAR IMPLEMENTATION PHASE, WE WILL FACILITATE THE IMPLEMENTATION OF MODULES 1–3, ENABLE THE FLOW OF QUALITY DATA AND SPECIMENS ACROSS THE NPHC, AND INTEGRATE CURATED, ARTIFICIAL INTELLIGENCE (AI)–READY DATA INTO THE ALL OF US RESEARCHER WORKBENCH, USING OUR ESTABLISHED DATA COORDINATION PROCESSES AND SYSTEMS. INNOVATIONS IN OUR APPROACH INCLUDE TOOLS FOR CONDUCTING DIETARY STUDIES IN HARD-TO-REACH POPULATIONS, IDIOGRAPHIC (OR SUBJECT-AS-OWN-CONTROL) CLINICAL TRIALS, AND WEARABLES RESEARCH TOOLS AND ANALYTICS. SPECIFICALLY, THE PROPOSED RCC WILL EXCEL IN ADMINISTRATING AND COORDINATING NPHC AND ITS RESEARCH INITIATIVES, CLINICAL INTERVENTIONS, AND DATA AND BIOSPECIMEN SHARING, AS FOLLOWS: AIM 1: OPTIMIZE THE SCIENTIFIC RIGOR OF MODULES 1–3 AIM 2: ENSURE NPHC STUDY DATA ARE FAIR (FINDABLE, ACCESSIBLE, INTEROPERABLE, AND REUSABLE) AIM 3: ENABLE SEAMLESS DATA COLLECTION, CURATION, AND TRANSFER INCLUDING TO THE RESEARCHER WORKBENCH AIM 4: MINIMIZE TIME TO LAUNCH OF MODULES 1–3 AIM 5: MAXIMIZE THE EFFICIENCY OF CONSORTIUM COMMUNICATIONS AND COLLABORATIONS NPHC IS BEING LAUNCHED TO ADDRESS MAJOR RESEARCH GAPS IN NUTRITION; THE NATURE OF THESE GAPS AND THE COMPLEXITY OF THE NPHC ACTIVITIES CANNOT BE UNDERSCORED ENOUGH. RCC WILL BE LED BY MULTIPLE PRINCIPAL INVESTIGATORS WITH COMPLEMENTARY EXPERTISE IN COORDINATING CENTER AND MULTISITE LEADERSHIP AND BIOSTATISTICS (DR. GANTZ AT RTI) AND NUTRITIONAL INTERVENTION AND CLINICAL EXPERTISE (DR. MEHTA AT CORNELL UNIVERSITY) WITH THE SUPPORT OF A STRONG AND DIVERSE TEAM, ORGANIZED AROUND CORES FOR DESIGN AND ANALYTICS, DATA CURATION AND SYSTEMS, AND STUDY IMPLEMENTATION. OTHER KEY COMPONENTS INCLUDE SINGLE IRB AND MEDICAL SAFETY MONITORING. THE RCC WILL ALSO BENEFIT FROM OUR COLLECTIVE INSTITUTIONAL STRENGTHS, WITH AN EXPERT POOL OF WIDE- RANGING RESEARCH AND CLINICAL BACKGROUNDS PERTINENT TO THE NPHC (E.G., OMICS, BIOINFORMATICS, AI, CLINICAL TRIAL INTERVENTION, NUTRITIONAL ASSESSMENT). THE PROPOSED RCC IS IMMEDIATELY AND AMPLY PREPARED TO SUPPORT TO NPHC IN ITS MISSION TO DEVELOP CLINICALLY MEANINGFUL ALGORITHMS THAT PREDICT INDIVIDUAL RESPONSES TO FOOD AND DIETARY PATTERNS AND TO IMPROVE HEALTH ACROSS DIVERSE U.S. POPULATIONS. PROJECT ABSTRACT

THE FOOD FOR PROGRESS PROGRAM PROVIDES FOR THE DONATION OF U.S. COMMODITIES TO DEVELOPING COUNTRIES AND EMERGING DEMOCRACIES THAT ARE COMMITTED TO INTRODUCING OR EXPANDING FREE ENTERPRISE IN THEIR AGRICULTURAL ECONOMIES. THE PROGRAM HAS TWO PRIMARY STRATEGIC OBJECTIVES: (1) INCREASE AGRICULTURAL PRODUCTIVITY AND (2) EXPAND TRADE OF AGRICULTURAL PRODUCTS.

PELVIC FLOOR DISORDERS NETWORK DATA COORDINATING CENTER: (2016-2021)

ENHANCING GLOBAL HEALTH SECURITY: EXPANDING EFFORTS AND STRATEGIES TO PROTECT AND IMPROVE PUBLIC HEALTH IN THE DEMOCRATIC REPUBLIC OF THE CONGO (DRC)

THE IPE ACTIVITY WILL INCREASE ACCESS TO SAFE, QUALITY BASIC EDUCATION FOR CHILDREN AND YOUTH BY IMPROVING SOCIO- ECONOMIC OPPORTUNITIES, CONTRIBUTING TO THE MULTI-SECTORAL IMPACTS OF VIOLENCE PREVENTION EFFORTS, AND DECREASING IRREGULAR MIGRATION.

USAID/UGANDA BIODIVERSITY FOR RESILIENCE ACTIVITY

HEALING COMMUNITIES STUDY DATA COORDINATING CENTER

PHILIPPINES HEALTHGOV2 LUZON

THE PRIMARY GOAL OF THE UZBEKISTAN EDUCATION REFORM IS TO DEVELOP, TEST, IMPLEMENT, AND EVALUATE EFFECTIVE AND SCALABLE EDUCATION REFORMS THAT IMPROVE LEARNING OUTCOMES FOR UZBEK STUDENTS THROUGHOUT THE COUNTRY.

TO ADVANCE DEMOCRATIC GOVERNANCE IN GUINEA THROUGH MULTI-SECTORAL INTERVENTIONS BY IMPROVING GOVERNANCE IN THE HEALTH, THE EDUCATION AND THE AGRICULT

MENTAL AND SUBSTANCE USE DISORDERS PREVALENCE STUDY

PHILIPPINES SUSTAINABLE INTERVENTIONS FOR BIODIVERSITY, OCEANS, AND LANDSCAPES (SIBOL) ACTIVITY

DESCRIPTION:THE PURPOSE OF THE ENVIRONMENTAL PROTECTION AGENCY'S (EPA) THRIVING COMMUNITIES GRANTMAKING PROGRAM ( EJ TCGM ) IS TO TRANSFORM DISADVANTAGED AND UNDERSERVED COMMUNITIES INTO HEALTHY, THRIVING PLACES THAT CAN ADDRESS THE HEALTH AND ENVIRONMENTAL CHALLENGES THEY FACE NOW AND INTO THE FUTURE. EPA WILL DO THIS BY USING A PASS-THROUGH MODEL TO DISTRIBUTE GRANT FUNDS TO COMMUNITIES VIA MULTIPLE GRANTMAKERS SERVING COMMUNITIES ACROSS THE NATION. RESEARCH TRIANGLE INSTITUTE (RTI) INTERNATIONAL HAS BEEN SELECTED TO SERVE AS THE EPA REGION 4 AND NATIONAL-CENTRAL GRANTMAKER PROVIDING SUPPORT TO COMMUNITIES ACROSS EPA REGIONS 4-7, WITH A DEDICATED FOCUS ON EPA REGION 7. RTI'S DIVERSE TEAM BRINGS EXPERTISE IN GRANT MANAGEMENT, ENVIRONMENTAL SCIENCE, ENVIRONMENTAL JUSTICE, EQUITY#8208;CENTERED RESEARCH AND EVALUATION. RTI'S PROPOSED SOLUTION ADVANCES RACIAL EQUITY BY POSITIONING COMMUNITY MEMBERS, AS PART OF A COMMUNITY ADVISORY BOARD (CAB), AS DECISION MAKERS IN SELECTING SUB AWARDEES AND SUBGRANTEES. RTI'S PROCESS INCLUDES TARGETED OUTREACH AND RECRUITMENT STRATEGIES INCLUSIVE AND ACCESSIBLE TO POTENTIAL APPLICANTS IN VARIOUS MODALITIES, AND CULTURALLY APPROPRIATE TO REACH COMMUNITIES. RTI INTERNATIONAL WILL SUPPORT THE INFRASTRUCTURE TO QUICKLY LAUNCH AN APPLICATIONS INTAKE, REVIEW, AND AWARD PROCESS THAT IS SIGNIFICANTLY SIMPLIFIED FROM CURRENT FEDERAL GRANTS PROCESSES. RTI INTERNATIONAL WILL RECEIVE AN INITIAL AWARD OF $25,000,000 OF INFLATION REDUCTION ACT (IRA) FUNDING TO STAND-UP THE INFRASTRUCTURE TO SUPPORT COMMUNITIES DIRECTLY, AS WELL AS SUPPORT THE REGIONAL GRANTMAKERS IN THE CENTRAL REGIONS AND THE EJ TCGM NETWORK AS A WHOLE. ONCE THE INFRASTRUCTURE IS ESTABLISHED, RTI INTERNATIONAL WILL RECEIVE A SUBSEQUENT AWARD OF $75,000,000 TO IMPLEMENT SUBGRANTING PROGRAMS IN EPA REGIONS 4 AND EPA REGIONS 7, AS WELL AS TO PROVIDE SUPPORT TO THE EJ TCGM NETWORK AS A WHOLE. THIS BIFURCATED AWARDS PROCESS IS BEING IMPLEMENTED BY EPA TO ENSURE THAT THE GRANTMAKERS HAVE SUFFICIENT TIME TO ESTABLISH THE NECESSARY GRANTMAKING INFRASTRUCTURE BEFORE BEGINNING TO ISSUE SUBGRANTS. THE EJ TCGM PROGRAM IS A KEY LEVER TO ADVANCE ENVIRONMENTAL JUSTICE AND IMPROVE PUBLIC HEALTH IN COMMUNITIES ACROSS THE CENTRAL REGIONS WHILE ENSURING THAT COMMUNITY MEMBERS CAN SHAPE THE PROCESS.ACTIVITIES:RTI INTERNATIONAL AND ITS PARTNERS WILL COME TOGETHER TO SERVE AS THE REGION 4 AND NATIONAL-CENTRAL GRANTMAKERS. ACTIVITIES TO BE PERFORMED DURING THIS PROJECT ARE: 1) RTI WILL WORK, IN CONSULTATION WITH EPA REGIONAL LEADERS AND COMMUNITY REPRESENTATIVES, TO IDENTIFY AND ENGAGE THREE (3) NEW STATUTORY PARTNERS LOCATED WITHIN REGION 7 TO ENSURE TCGM PROVIDES DIRECT SUPPORT TO COMMUNITIES WITHIN THE REGION. 2) RTI INTERNATIONAL WILL IMPLEMENT THE COMMUNITY-ENGAGED TRANSFORMATIVE GOVERNANCE MODEL TO SUPPORT THE TYPE OF DECISION-MAKING THAT ACKNOWLEDGES THAT COMMUNITY ORGANIZATIONS HAVE THE AUTHORITY TO DEFINE SUCCESS FOR THEIR PROJECTS, DECIDE ON THE TYPE OF INTERVENTIONS THEY MOST NEED, AND CONTRIBUTE TO THE GRANTMAKING PROCESS. THE COMMUNITY ADVISORY BOARDS (CABS) ARE THE CORNERSTONE OF THE PROGRAM. WHILE APPLICATIONS WILL BE ACCEPTED ON A ROLLING BASIS, CABS WILL MEET TO MAKE FUNDING DECISIONS ON A QUARTERLY BASIS. THEY ARE ALSO CHARGED WITH GUIDING THE PROGRAM IMPLEMENTATION WITHIN THE REGIONS. IN CONSULTATION WITH EPA REGIONAL LEADERS, TCGM PARTNERS, AND COMMUNITY MEMBER INPUT, RTI WILL DEVELOP SELECTION CRITERIA TO SELECT COMMUNITY ADVISORY BOARD (CAB) MEMBERS. RTI WILL WORK CLOSELY TO ENSURE THAT SELECTION FOR CAB MEMBERS CONSIDERS CONTEXTUAL EQUITY CONSIDERATIONS SO THAT THE TCGM PROGRAM CAN SERVE THOSE COMMUNITIES THAT IT IS INTENDED TO BENEFIT. 3) THE COMMUNICATIONS AND OUTREACH TEAM WILL DEVELOP OUTREACH STRATEGIES THAT INCLUDE BOTH DIRECT IN-PERSON OUTREACH AND INDIRECT COMMUNICATION CHANNELS FOR THE COMPLETE LIFE CYCLE OF THE GRANT PROGRAM. FOR REGION 4 AND REGION 7, THE COMMUNICATIONS AND OUTREACH TEAM WILL

SUPPORT USAID INTEGRATION STRATEGY FOR STRENGTHENING LOAL GOVT. TO IMPROVE BASIC SERVICES: HEALTH EDUCATION WASH AND FOOD SECURITY.

MULTI-SECTOR ALLIANCES PROGRAM

HEALTHGOV-LGU COMPONENT

DATA COORDINATING CENTER (DCC) FOR THE NEONATAL OPIOID WITHDRAWAL SYNDROME PHARMACOLOGICAL TREATMENTS COMPARATIVE EFFECTIVENESS TRIAL (NOWS PHACET) - PROJECT SUMMARY/ABSTRACT MAJOR KNOWLEDGE GAPS EXIST IN OPTIMIZING PHARMACOLOGIC TREATMENT FOR NEONATAL OPIOID WITHDRAWAL SYNDROME (NOWS), A PRESSING PUBLIC HEALTH ISSUE. RIGOROUS, HIGH QUALITY, RANDOMIZED TRIALS ARE URGENTLY NEEDED TO DEVELOP THE EVIDENCE BASE AND BEST PRACTICES FOR NEONATAL MEDICINE IN THIS AREA. IN RESPONSE, THE NICHD HEAL INITIATIVE NOWS PHARMACOLOGICAL TREATMENTS COMPARATIVE EFFECTIVENESS TRIAL (NOWS PHACET) CONSORTIUM WILL DESIGN AND IMPLEMENT A MULTI-CENTER, COMPARATIVE EFFECTIVENESS, RANDOMIZED CONTROLLED TRIAL (RCT) TO ASSESS THE OPTIMAL PHARMACOLOGICAL TREATMENT FOR NOWS THAT INFORMS CLINICAL PRACTICE GUIDELINES. THERE IS A CRUCIAL NEED FOR AN INDEPENDENT AND EXPERIENCED DATA COORDINATING CENTER (DCC) TO PROVIDE HIGH-QUALITY AND IMPARTIAL BIOSTATISTICAL EXPERTISE TO ADDRESS THE SUBSTANTIAL METHODOLOGIC CHALLENGES IN THE DESIGN AND CONDUCT OF SUCH A TRIAL BY (1) BUILDING CONSENSUS TO HELP IDENTIFY CRITICAL METHODOLOGIC ISSUES; (2) BRINGING OBJECTIVE STATISTICAL EXPERTISE TO THE CONCEPTION, DESIGN, AND ANALYSES OF A RIGOROUS AND FEASIBLE RANDOMIZED TRIAL (WITH APPROPRIATE MONITORING); (3) DEVELOPING PROCESSES AND SYSTEMS TO INCREASE THE EFFICIENCY OF THE CONSORTIUM, ENSURE TRIAL FEASIBILITY, AND EFFECTIVE USE OF LIMITED TRIAL PARTICIPANTS AND RESOURCES; (4) ENSURING STANDARDIZATION OF STUDY DESIGN, DEVELOPMENT, DATA COLLECTION, DATA QUALITY, AND DATA ANALYSES WITH EXISTING HEAL ACTIVITIES; AND (5) DISSEMINATION OF STUDY RESULTS, PUBLIC REPORTS, AND PUBLIC USE DATA. AS LONGTIME DCC FOR THE NICHD NEONATAL RESEARCH NETWORK (NRN) AND THE ONGOING ADVANCING CLINICAL TRIALS IN NEONATAL OPIOID WITHDRAWAL (ACT NOW) STUDIES, RTI HAS SUCCESSFULLY COLLABORATED IN THE DESIGN AND IMPLEMENTATION OF 30+ RCTS IN NEONATES INFORMING CLINICAL PRACTICE. OUR SPECIFIC AIMS AS THE DCC FOR NOWS PHACET ARE TO (1) ENHANCE THE SCIENTIFIC RIGOR OF THE CONSORTIUM BY COLLABORATIVELY BUILDING CONSENSUS FOR A UNIFORM PROTOCOL THAT ADDRESSES THE UNIQUE FEASIBILITY AND IMPLEMENTATION CHALLENGES OF PHARMACOLOGICAL RCTS IN NOWS; (2) OPTIMIZE PRODUCTIVITY WITH FLEXIBLE, EFFICIENT, AND HIGH QUALITY DATA AND STUDY MANAGEMENT, AND PROMOTE HEAL DATA HARMONIZATION AND SHARING; (3) PROTECT PARTICIPANT SAFETY AND STUDY INTEGRITY WORKING WITH THE INDEPENDENT DATA SAFETY AND MONITORING COMMITTEE (DSMC), SINGLE IRB (SIRB), NICHD, AND FDA (AS NEEDED); (4) PROVIDE TIMELY REPORTING AND DATA ANALYSIS, AND COLLABORATE WITH INVESTIGATORS ON ALL CONSORTIUM ANALYSES AND PUBLICATIONS; AND (5) PROVIDE THE NECESSARY LOGISTICAL, CONTRACTUAL, COMMUNICATIONS, AND REGULATORY SUPPORT. THE UNIQUE STRENGTHS OF THIS APPLICATION INCLUDE (1) A HIGHLY QUALIFIED PI AND STAFF UNIQUELY EXPERIENCED IN ALL ASPECTS OF BOTH NEONATAL AND NOWS TRIALS INCLUDING NEURODEVELOPMENTAL FOLLOW-UP; (2) PROVEN TRACK RECORD OF COLLABORATION AND SCIENTIFIC PRODUCTIVITY IN PERINATAL STUDIES; (3) STATE-OF-THE-ART INFRASTRUCTURE OF FLEXIBLE TOOLS, PROCESSES, AND SYSTEMS CUSTOMIZED FOR NEONATAL/ NOWS RCTS INCORPORATING FOLLOW-UP; (4) MULTIDISCIPLINARY EXPERTS AVAILABLE AS NEEDED; AND (5) DEPTH AND BREADTH OF EXPERT STAFF WITH AN AGILE ADMINISTRATIVE STRUCTURE THAT CAN RESPOND QUICKLY TO CHANGING NEEDS.

EXCELLENCE IN HIGHER EDUCATION FOR LIBERIAN DEVELOPMENT (EHELD)

PRESIDENT''S MALARIA INITIATIVE PROGRAM

CRIME PREVENTION PROJECT

CONTINUATION OF THE NUMOM2B HEART HEALTH STUDY

A NEW ONE YEAR COOPERATIVE AGREEMENT WITH A TEC OF 3,356,770 AND INITIAL OBLIGATION OF $2,812,000

THE PURPOSE OF THE USAID/SENEGAL'S MILLENNIUM WATER AND SANITATION PROGRAM (USAID/PEPAM) DESCRIBED HEREIN IS TO IMPROVE SUSTAINABLE ACCESS TO WATER A

USAID/CAMBODIA INTEGRATED EARLY CHILDHOOD DEVELOPMENT (IECD) ACTIVITY

THE PURPOSE OF THIS AWARD IS TO PROVIDE ASSISTANCE FOR IMPLEMENTING THE AGRICULTURAL PRODUCTION COMPONENT OF THE MALI GLOBAL FOOD SECURITY STRATEGY FOR A SUSTAINABLE INTENSIFICATION OF TARGET VALUE CHAINS IN THE SIKASSO REGION.

GENOMIC RESOURCE GRANT FOR PHENX TOOLKIT (U41)

PELVIC FLOOR DISORDERS NETWORK DATA COORDINATING CENTER (U01)

USAID "UMUHIMU WA TAKWIMU ZA MALARIA" ACTIVITY¿S THEORY OF CHANGE STIPULATES THAT THE GOAL OF REDUCING MALARIA BURDEN AND MOVING MAINLAND TANZANIA AND ZANZIBAR TOWARD MALARIA ELIMINATION WILL BE ACHIEVED IF: (1) MALARIA SURVEILLANCE IS IMPROVED (RESULT 1); (2) ENTOMOLOGICAL MONITORING IS IMPROVED (RESULT 2); (3) DRUG EFFICACY MONITORING IS IMPROVED (RESULT 3); AND (4) GOT¿S EVIDENCE-BASED DECISION MAKING IS IMPROVED (RESULT 4) TO ACHIEVE THE ABOVE VISION, THE RECIPIENT¿S DESIGNED TECHNICAL APPROACH IS DIVIDED BY SIX GUIDING IMPLEMENTATION STRATEGIES THAT WILL ENABLE A SUCCESSFULLY EXECUTED USAID UMUHIMU WA TAKWIMU ZA MALARIA ACTIVITY SUSTAIN RESULTS THROUGH PROGRAMMATIC INTEGRATION, LOCAL OWNERSHIP, AND CAPACITY STRENGTHENING

PRETERM BIRTH IN NULLIPAROUS WOMEN: AN UNDERSTUDIED POPULATION AT GREAT RISK

FORENSIC TECHNOLOGY CENTER OF EXCELLENCE (FTCOE) FY17

GLOBAL NETWORK DATA COORDINATING CENTER

BASIC EDUCATION QUALITY AND TRANSITIONS ACTIVITY

GLOBAL NETWORK FOR WOMEN'S AND CHILDREN'S HEALTH RESEARCH DATA COORDINATING CENTER

FORENSIC SCIENCE TRAINING DEVELOPMENT AND DELIVERY PROGRAM

THE SHOBAI MILEY SHIKHI (“EVERYONE LEARNS TOGETHER”) ACTIVITY MAINLY AIMS TO IMPROVE LEARNING OUTCOMES FOR CHILDREN WITH DISABILITIES (CWD) IN BANGLADESH

2009 NATIONAL INMATE SURVEY

TO SUPPORT USAID/SENEGAL AND GOVERNMENT OF SENEGAL'S OBJECTIVE: BETTER EDUCATED YOUTH BY IMPROVING THE QUALITY OF BASIC EDUCATION FOR MIDDLE-SCHOOL A

IMPROVING CLINICAL AND PUBLIC HEALTH OUTCOMES THROUGH NATIONAL PARTNERSHIPS TO PREVENT AND CONTROL EMERGING AND RE-EMERGING INFECTIOUS DISEASE THREATS - SEE EVALUATION AND PERFORMANCE MGMT PLAN

ACHIEVING STUDENT CENTERED EDUCATION FOR A NEW TOMORROW (ASCENT)

THE CRIMINAL JUSTICE TESTING AND EVALUATION CENTER (CJTEC) PROVIDES RIGOROUS AND INDEPENDENT INFORMATION TO THE CRIMINAL JUSTICE COMMUNITY CONCERNING EMERGING TECHNOLOGIES AND PRACTICES IN LAW ENFORCEMENT, CORRECTIONS, COURTS, FORENSIC LABORATORIES, AND JUVENILE JUSTICE PROGRAMS. CJTEC WILL INFORM RESEARCH AND TECHNOLOGY ADOPTIONS BASED ON INPUT FROM PRACTITIONERS, STAKEHOLDERS, POLICYMAKERS, RESEARCHERS, AND INDUSTRY. WITH DIRECTION FROM THE NATIONAL INSTITUTE OF JUSTICE (NIJ), RTI INTERNATIONAL WILL PROVIDE OPERATIONAL OVERSIGHT AND TECHNICAL CAPACITY FOR THE CENTER WHICH WILL FOCUS ON FIVE PRIMARY TASKS: (1) CONDUCTING SECONDARY RESEARCH ON TECHNOLOGIES AND TECHNOLOGY IMPLEMENTATION FOR POTENTIAL USE BY CRIMINAL JUSTICE COMMUNITIES; (2) PERFORMING EXPERIMENTAL TESTING AND EVALUATION ON TECHNOLOGIES TO INFORM POTENTIAL ADOPTION; (3) CONDUCTING EXPERIMENTAL OR RIGOROUS QUASI-EXPERIMENTAL RESEARCH AND EVALUATION OF TECHNOLOGY IMPLEMENTATION; (4)ADMINISTERING THE NIJ COMPLIANCE TESTING PROGRAM; AND (5)SUPPORTING THE DEVELOPMENT, VALIDATION, AND MAINTENANCE OF CRIMINAL JUSTICE EQUIPMENT STANDARDS. CJTEC ACTS AS AN HONEST BROKER TO PROVIDE TECHNOLOGY AND IMPLEMENTATION INSIGHTS AND RIGOROUS RESEARCH, TESTING, AND EVALUATION TO EXAMINE SYSTEM PERFORMANCE, SAFETY, AND OPERATIONAL IMPACT WHILE ADDRESSING POTENTIAL UNINTENDED CONSEQUENCES OF PRACTITIONER ADOPTION IN REAL-WORLD SETTINGS. NCA/NCF

USAID DISASTER RISK MANAGEMENT (DRM) ACTIVITY

NEW AWARD TO RESEARCH TRIANGLE INSTITUTE UNDER REFUEL+IT FOA CONTROL NO: 2373-1502 TITLE: NEXT-GENERATION AMMONIA SYSTEM INTEGRATION UTILIZING INTERMITTENT RENEWABLE POWER RTI AND ITS PARTNERS PROPOSE TO DEVELOP A TECHNOLOGY INTEGRATION PLATFORM (TIP) TO DEMONSTRATE NEXT-GENERATION TECHNOLOGIES FOR AMMONIA (NH3) PRODUCTION AND UTILIZATION IN A MODULAR, LOAD-RESPONSIVE TESTBED AT 1 METRIC TON PER DAY SCALES FROM INTERMITTENT RENEWABLE ELECTRICITY.

ADMINISTRATIVE SUPPLEMENT FOR ACT NOW OBOE LONGITUDINAL STUDY

INCLUDE DOWN SYNDROME CLINICAL COHORT COORDINATING CENTER (DS-4C) - PROJECT SUMMARY/ABSTRACT THE OVERARCHING GOAL OF THE PROPOSED INCLUDE CLINICAL COHORT COORDINATING CENTER (DS-4C), CO-LED BY INVESTIGATORS AT RTI INTERNATIONAL AND EMORY UNIVERSITY, IS TO IMPROVE THE HEALTH AND WELL-BEING OF INDIVIDUALS WITH DOWN SYNDROME (DS) BY SUPPORTING THE INCLUDE PROJECT’S DS COHORT DEVELOPMENT PROGRAM (DS-CDP). IN THIS CAPACITY, THE DS-4C WILL SERVE AS THE CENTRAL HUB FOR ORCHESTRATING AND INTEGRATING ALL COMPONENTS OF THE DS-CDP, INCLUDING OVERSEEING THE DEVELOPMENT AND IMPLEMENTATION OF A COMMON PROTOCOL TO GUIDE HARMONIZED DATA COLLECTION ACROSS MULTIPLE DS COHORT RESEARCH SITES (DS-CRS) IN THE DS-CDP AND FACILITATING DATA TRANSFER INTO THE INCLUDE DATA COORDINATING CENTER (DCC) AND DATA HUB FOR AVAILABILITY TO RESEARCHERS. THE COMPLEX STRUCTURE OF THE DS-CDP REQUIRES THE DS-4C’S EXPERT LEADERSHIP AND COORDINATION TO GENERATE AN EFFECTIVE, INTEGRATED, UNIFIED NETWORK TO ACHIEVE THE GOAL OF GENERATING DEEP PHENOTYPING DATA AND COLLECTING BIOSPECIMENS IN A LARGE, DIVERSE COHORT OF INDIVIDUALS WITH DS ACROSS THE LIFESPAN TO SUPPORT FUTURE RESEARCH EFFORTS TO IMPROVE DS-ASSOCIATED CO-MORBIDITIES. THE FOUR CORES OF THE DS-4C (ADMINISTRATIVE, COHORT, OUTREACH, AND DATA MANAGEMENT) WILL LEVERAGE THE EXPERTISE OF CORE STAFF AND WORK COLLABORATIVELY TO PROVIDE ADMINISTRATIVE SUPPORT TO FACILITATE COLLABORATION AND COMMUNICATION ACROSS THE DS-CDP; ENSURE SEAMLESS IMPLEMENTATION OF THE PROTOCOL; IMPLEMENT AND SUPPORT INCLUSIVE OUTREACH EFFORTS TO FACILITATE INCLUSION AND REPRESENTATION IN RECRUITMENT; AND MANAGE THE FLOW OF DATA AND BIOSPECIMENS FROM THE DS-CRS TO THE INCLUDE DCC AND DATA HUB AND DS-BIOREPOSITORY, RESPECTIVELY. OUR SPECIFIC AIMS ARE AS FOLLOWS: AIM 1: IMPLEMENT TOOLS AND SYSTEMS TO FOSTER SEAMLESS INTEGRATION AND OPERATIONAL EFFICIENCY WITHIN THE DS-4C AND ACROSS THE DS-CDP. AIM 2: PROVIDE EXPERTISE AND RESOURCES TO DEVELOP AND IMPLEMENT THE COMMON PROTOCOL ACROSS THE DS-CDP WHILE ENHANCING THE SCIENTIFIC RIGOR OF DS-CRS STUDIES TO MAXIMIZE THE SCIENTIFIC IMPACT OF THE INCLUDE PROJECT. AIM 3: ENHANCE COMMUNITY ENGAGEMENT, FACILITATE RECRUITMENT OF PARTICIPANTS AND TEAM MEMBERS FROM TYPICALLY UNDERREPRESENTED GROUPS, ADVANCE HEALTH EQUITY GOALS, AND PROMOTE AWARENESS OF THE INCLUDE PROGRAM. AIM 4: MANAGE THE FLOW OF DATA FROM DS-CRS INTO THE INCLUDE DCC AND DATA HUB FOR ACCESS BY THE DS RESEARCH COMMUNITY. THE DS-4C WILL BE LED BY MULTIPLE PRINCIPAL INVESTIGATORS, DR. HUNTER AT RTI AND DR. ROSSER AT EMORY, WITH A COLLABORATIVE HISTORY AND EXTENSIVE EXPERTISE IN ELUCIDATING HEALTH OUTCOMES OF INDIVIDUALS WITH DS THROUGH PHENOTYPIC PROTOCOL DEVELOPMENT, BIOSPECIMEN COLLECTION, MULTI-SITE RECRUITMENT EFFORTS, AND DATA HARMONIZATION. THE PROPOSED DS-4C IS IMMEDIATELY AND AMPLY PREPARED TO SUPPORT ITS MISSION TO DEVELOP CLINICALLY MEANINGFUL FINDINGS THAT POSITIVELY IMPACT THOSE AFFECTED BY DS.

PREGNANCY AS A WINDOW TO FUTURE CARDIOVASCULAR HEALTH: ADVERSE PREGNANCY OUTCOMES

THE SEXUAL ASSAULT KIT INITIATIVE: NATIONAL TRAINING AND TECHNICAL ASSISTANCE

THE SEXUAL ASSAULT KIT INITIATIVE: NATIONAL TRAINING AND TECHNICAL ASSISTANCE PROGRAM

A THIN FILM POLYMER DEVICE (TFPD) THAT IS A SUBCUTANEOUSLY INJECTED AND BIODEGRADABLE.

BUILDING HEALTH DATA DISSEMINATION AND INFORMATION USE SYSTEMS IN THE REPUBLIC OF

EMERGING INFECTIOUS DISEASES RESEARCH CENTERS COORDINATION CENTER (EIDRC CC)

HEAL INITIATIVE: COORDINATING CENTER TO SUPPORT NIDA PREVENTING OPIOID USE DISORDER IN OLDER ADOLESCENTS AND YOUNG ADULTS

DOD ALCOHOL AND SUBSTANCE ABUSE CONSORTIUM AWARD

ALCOHOL AND SUBSTANCE ABUSE DISORDERS RESEARCH PROGRAM CONSORTIUM AWARD

INTEGRATIVE OMICS CENTER FOR ACCELERATING NEUROBIOLOGICAL UNDERSTANDING OF OPIOID ADDICTION (ICAN) - PROJECT SUMMARY/ABSTRACT THE OVERARCHING GOAL OF THE INTEGRATIVE OMICS CENTER FOR ACCELERATING NEUROBIOLOGICAL UNDERSTANDING OF OPIOID ADDICTION (ICAN) IS TO IDENTIFY BIOLOGICALLY ACTIONABLE DRIVERS OF OPIOID ADDICTION (OA). WE WILL (1) CONDUCT LARGE-SCALE INTEGRATED MULTI-OMICS STUDIES OF OA IN HUMANS, (2) INTEGRATE RODENT–HUMAN STUDIES TO IDENTIFY GENES AND GENE NETWORKS IMPLICATED IN OA, AND (3) BUILD A PUBLICLY AVAILABLE NATIONAL OMICS RESOURCE FOR STUDYING OA. OUR COHERING PRINCIPLE IS THAT BY INTEGRATING MULTIPLE OMICS ACROSS HUMAN AND ANIMAL MODEL DATA WE WILL DISCOVER ROBUST DRIVERS OF INDIVIDUAL VARIATION THAT PREDISPOSE OPIOID USERS TO ADDICTION. THE OMICS REVOLUTION HAS DELIVERED MANY DISCOVERIES OF SUCH INDIVIDUAL VARIATION FOR COMPLEX DISEASES, INCLUDING FOR NICOTINE AND ALCOHOL PHENOTYPES, BUT NOT FOR OA. WE SEE FIVE FUNDAMENTAL CHALLENGES TO RAPID PROGRESS: (1) LIMITED SAMPLE SIZES AND UNACCOUNTED-FOR PHENOTYPIC HETEROGENEITY IN GENOME-WIDE ASSOCIATION STUDIES (GWAS) OF OA; (2) VERY LIMITED HUMAN BRAIN STUDIES OF GENE DYSREGULATION BY OA; (3) POOR TRANSLATION BETWEEN HUMAN AND ANIMAL MODEL STUDIES; (4) LACK OF CONCURRENT INTEGRATION OF MULTIPLE OMICS; AND (5) LIMITED PRACTICAL ACCESS TO, AND POOR HARMONIZATION OF, OA OMICS DATA. TO OVERCOME THESE CHALLENGES, ICAN HARNESSES FOUR PROJECTS AND TWO CORES: PROJECT 1: ELECTRONIC HEALTH RECORD PHENOTYPING AND GENOMICS OF OPIOID ADDICTION PROJECT 2: GENE REGULATION IN THE OPIOID DEPENDENT HUMAN BRAIN PROJECT 3: MULTI-SPECIES APPROACH TO OPIOID ADDICTION PROJECT 4: MULTI-OMICS GENE NETWORK IDENTIFICATION CORES: ADMINISTRATIVE CORE AND SYNERGY CORE ACROSS THESE PROJECTS AND CORES, WE WILL (1) CONDUCT THE LARGEST GWAS TO DATE (N>100,000 CASES) LEVERAGING GENOMIC STRUCTURAL EQUATION MODELING; (2) EXAMINE DIFFERENTIAL GENE REGULATION ACROSS KEY BRAIN REGIONS (PREFRONTAL CORTEX, NUCLEUS ACCUMBENS, AMYGDALA) IN THE LARGEST COLLECTION OF OA INFORMATIVE POSTMORTEM BRAINS TO DATE (N=641); (3) INTEGRATE RODENT AND HUMAN STUDIES USING GENEWEAVER.ORG, POLYGENIC TRANSCRIPTOME RISK SCORES, AND VARIANT FUNCTIONALIZING EXPERIMENTS; AND (4) APPLY EXPLAINABLE ARTIFICIAL INTELLIGENCE, GENE NETWORK MAPPING, AND MULTIPLE LINES-OF-EVIDENCE INTEGRATION FOR GENE NETWORK DISCOVERY. EACH PROJECT IS RIGOROUSLY DESIGNED TO MAKE NOVEL CONTRIBUTIONS. HOWEVER, BY INTEGRATING THE DIVERSITY OF ICAN’S SCIENCE THROUGH THE CROSS-FERTILIZATION AND COORDINATING EFFORTS OF THE CORES, WE WILL LEVERAGE THE AGNOSTIC DISCOVERY POWER OF OMICS AND PLACE IT WITHIN THE CONTEXT OF FUNCTIONAL NEUROBIOLOGY TO MAKE FIELD-CHANGING BREAKTHROUGHS AND IDENTIFY ACTIONABLE TARGETS FOR DEVELOPMENT OF OA TREATMENTS.

THE PURPOSE OF THIS ACTIVITY IS TO INCREASE ECONOMIC DEVELOPMENT AND FOOD SECURITY IN LIBERIA.

PHARMACOTHERAPIES FOR ALCOHOL AND SUBSTANCE USE DISORDER RESEARCH PROGRAM CONSORTIUM

NEW HIGHER EDUCATION ACTIVITY

CRIMINAL JUSTICE TESTING AND EVALUATION CONSORTIUM

MODELING OF INFECTIOUS DISEASE AGENT STUDY INFORMATION TECHNOLOGY

NATIONAL INMATE SURVEY (NIS-4) 2018-19

FY08 DRMRP CLINICAL TRIAL: STRENGTHENING PATHWAYS TO PTSD RECOVERY USING SYSTEMS-LEVEL INTERVENTION

NEW AWARD DE-FE0031590 WITH RESEARCH TRIANGLE INSTITUTE TITLED ENGINEERING SCALE TESTING OF TRANSFORMATIONAL NON-AQUEOUS SOLVENT-BASED CARBON DIOXIDE CAPTURE PROCESS AT TECHNOLOGY CENTRE MONGSTAD

WORKPLACE POLICIES AND PRACTICES COORDINATING CENTER

THE PURPOSE OF THIS REQUISITION IS TO SUPPORT THE GON IN THE SCALE-UP OF THE NATIONAL EARLY GRADE READING PROGRAM. THE LIFE OF THE ACTIVITY IS TWO YEARS I.E. JULY 2020 TO JULY 2022.

USAID'S STRENGTHENING LOCAL LEVEL HEALTH SYSTEM ACTIVITY

CHRONIC KIDNEY DISEASES OF UNCERTAIN ETIOLOGY (CKDU) IN AGRICULTURAL COMMUNITIES (CURE) RESEARCH CONSORTIUM - SDCC - PROJECT SUMMARY/ABSTRACT A GROWING NUMBER OF GEOGRAPHICALLY DIVERSE REGIONS AROUND THE WORLD REPORT INCREASING RATES OF CHRONIC KIDNEY DISEASE OF UNCERTAIN OR UNKNOWN ETIOLOGY (CKDU), A LIFE-THREATENING CONDITION NOT ATTRIBUTABLE TO TRADITIONAL CHRONIC KIDNEY DISEASE RISK FACTORS. YET, THE ETIOLOGY OF CKDU REMAINS UNCLEAR AND DATA ARE LACKING ON CKDU PROGRESSION, BIOLOGICAL MANIFESTATIONS, GENETIC DETERMINANTS, AND RISK FACTORS THAT MAY EXPLAIN REGIONAL VARIATIONS. TO ADDRESS THESE CHALLENGES, THE NATIONAL INSTITUTES OF HEALTH HAS FORMED THE CHRONIC KIDNEY DISEASES OF UNCERTAIN ETIOLOGY (CKDU) IN AGRICULTURAL COMMUNITIES (CURE) RESEARCH CONSORTIUM. THE CONSORTIUM WILL DEVELOP A HARMONIZED STUDY PROTOCOL THAT CAN BE IMPLEMENTED IN MULTIPLE ENDEMIC REGIONS TO UNDERSTAND THE ETIOLOGIES OF CKDU AND DISEASE PROGRESSION AND TO IDENTIFY POTENTIAL THERAPEUTIC TARGETS AND PUBLIC HEALTH INTERVENTIONS. RTI INTERNATIONAL AND BOSTON UNIVERSITY ALONG WITH OUR PARTNERS FROM HARVARD UNIVERSITY, NATIONAL AUTONOMOUS UNIVERSITY OF NICARAGUA, UNIVERSITY OF COLORADO, AND STANFORD UNIVERSITY, PROPOSE TO ESTABLISH THE CURE RESEARCH CONSORTIUM SCIENTIFIC DATA COORDINATING CENTER (SDCC). THE SDCC WILL PROVIDE THE LEADERSHIP, INFRASTRUCTURE, AND TOOLS TO UNITE THE FIELD EPIDEMIOLOGY SITES, RENAL SCIENCE CORE, HUMAN HEALTH EXPOSURE ANALYSIS RESOURCE, AND NIH INTO A COHESIVE WHOLE BY PROMOTING CONSENSUS BUILDING AND COLLABORATIVE DECISION MAKING. THE SDCC'S ROLE IN CULTIVATING A COMMON RESEARCH AGENDA IS CRUCIAL TO THE CURE RESEARCH CONSORTIUM'S ABILITY TO IMPLEMENT ETHICAL EPIDEMIOLOGY RESEARCH DESIGNS; COMMON APPROACHES FOR DATA COLLECTION, AND BIOLOGICAL AND ENVIRONMENTAL ASSESSMENTS; BEST PRACTICES FOR DATA ANALYSIS AND DISSEMINATION; AND ANCILLARY RESEARCH STUDIES. SPECIFICALLY, THE SDCC WILL SUPPORT THE RESEARCH CONSORTIUM BY ACCOMPLISHING THE FOLLOWING AIMS: (1) ELUCIDATE THE LIKELY MULTIFACTORIAL ETIOLOGIES OF CKDU DEVELOPMENT AND PROGRESSION IN ENDEMIC REGIONS BY INTEGRATING A CLASSIC CASE-CONTROL STUDY WITH LONGITUDINAL ASSESSMENTS OF CASES TO ASSESS FACTORS FOR DISEASE PROGRESSION AND CONTROLS TO CAPTURE CKDU DEVELOPMENT; (2) PROMOTE CONSENSUS BUILDING AND FOSTER COLLABORATION AND COORDINATION BY PROVIDING SCIENTIFIC LEADERSHIP, EXPERTISE IN DATA SCIENCE AND ROBUST ANALYTICAL METHODS, AND COMMUNICATION, LOGISTICAL, AND OPERATIONAL SUPPORT; AND (3) ENHANCE CONSORTIUM RESEARCH EFFICIENCY, PRODUCTIVITY, AND SCIENTIFIC RIGOR BY PROVIDING SOUND STUDY MONITORING AND OVERSIGHT AND ESTABLISHING EFFICIENT DATA AND SPECIMEN MANAGEMENT SYSTEMS USING RELEVANT TECHNOLOGY AND DATA VISUALIZATION TOOLS. TOGETHER WITH A MULTIDISCIPLINARY TEAM OF CO-INVESTIGATORS, THE SDCC MULTIPLE PIS, JILL LEBOV, PHD (CONTACT PI), MARIE GANTZ, PHD, AND DANIEL BROOKS, PHD, BRING THE REQUIRED SCIENTIFIC AND ORGANIZATIONAL CAPABILITIES IN CONSORTIUM COORDINATION, PROJECT MANAGEMENT, EPIDEMIOLOGY, BIOSTATISTICS, DATA SCIENCE, NEPHROLOGY AND KIDNEY DISEASE RESEARCH, ENVIRONMENTAL AND OCCUPATIONAL HEALTH, GENETICS, AND ETHICAL CONDUCT OF INTERNATIONAL RESEARCH IN RESOURCE-LIMITED SETTINGS TO EFFECTIVELY MANAGE THE ACTIVITIES OF THE SDCC, THE CURE RESEARCH CONSORTIUM, AND THE CURE STUDY.

EDUCATION SECTOR REFORM ASSISTANCE (ESRA)

DESCRIPTION:THIS ACTION PROVIDES FUNDING IN THE AMOUNT OF $4,000,000 FOR RESEARCH TRIANGLE INSTITUTE (RTI) TO PROVIDE MEANINGFUL ENGAGEMENT TO UNDERSERVED COMMUNITIES IN THE SOUTHEAST REGION OF THE UNITED STATES (REGION 4). THE ACTIVITIES TO BE PERFORMED UNDER THIS GRANT INCLUDE IDENTIFYING ENVIRONMENTAL AND ENERGY JUSTICE ISSUES, INCLUDING GEOGRAPHICAL ANALYSES USING GIS, AIR AND WATER QUALITY MONITORING, PERSONAL EXPOSURE ANALYSES, CLIMATE RESILIENCE ANALYSES, AND ENERGY POLICY IMPACT ASSESSMENTS. ADDITIONAL ACTIVITIES TO BE PERFORMED UNDER THIS GRANT ARE TO ASSIST PROGRAM PARTICIPANTS WITH NAVIGATING GOVERNMENT SYSTEMS, IDENTIFYING GRANT OPPORTUNITIES, APPLYING FOR GRANTS, AND MANAGING GRANTS. THE ANTICIPATED DELIVERABLES INCLUDE DOCUMENTATION FROM OUTREACH EFFORTS UNDERTAKEN, DESCRIPTIONS OF SERVICES PROVIDED, NUMBER OF PROGRAM PARTICIPANTS, TOOLS DEVELOPED, REPORTS ON FEEDBACK FROM PROGRAM PARTICIPANTS, PROGRAM EVALUATIONS, NUMBER OF IMPROVEMENTS MADE TO AN ENVIRONMENTAL JUSTICE THRIVING COMMUNITIES TECHNICAL ASSISTANCE CENTERS (EJ TCTAC), AND THE NUMBER OF CLEAN ENERGY DEMONSTRATION OPPORTUNITIES IDENTIFIED. THE EXPECTED OUTCOMES INCLUDE INCREASED AWARENESS, KNOWLEDGE AND UNDERSTANDING OF GRANT AMONG UNDERSERVED COMMUNITIES, INCREASED ACCESS TO GRANT WRITING AND MANAGEMENT RESOURCES, AND AN INCREASE TO THE NUMBER AND QUALITY OF APPLICATIONS FOR FUNDING RELATED TO ENVIRONMENTAL AND ENERGY JUSTICE FROM UNDERSERVED COMMUNITIES IN THE SOUTHEAST REGION. THE INTENDED BENEFICIARIES INCLUDE COMMUNITIES THROUGHOUT EACH OF THE REGION 4 STATES: (AL, FL, GA, KY, MS, NC, SC, TN). THE OUTCOMES OF THIS PROJECT WILL INCLUDE THE INCREASED GRANT WRITING CAPACITY, INCREASED COMMUNITY ENGAGEMENT, AND INCREASED PRODUCE YIELDED FROM THE GARDEN TO BENEFIT THE UNDERSERVED COMMUNITIES IN THE JACKSON, MISSISSIPPI AREA. ACTIVITIES:THE ACTIVITIES TO BE PERFORMED UNDER THIS GRANT INCLUDE IDENTIFYING ENVIRONMENTAL AND ENERGY JUSTICE ISSUES, INCLUDING GEOGRAPHICAL ANALYSES USING GIS, AIR AND WATER QUALITY MONITORING, PERSONAL EXPOSURE ANALYSES, CLIMATE RESILIENCE ANALYSES, AND ENERGY POLICY IMPACT ASSESSMENTS. ADDITIONAL ACTIVITIES TO BE PERFORMED UNDER THIS GRANT ARE TO ASSIST PROGRAM PARTICIPANTS WITH NAVIGATING GOVERNMENT SYSTEMS, IDENTIFYING GRANT OPPORTUNITIES, APPLYING FOR GRANTS, AND MANAGING GRANTS. RTI WILL FACILITATE COMMUNITY ENGAGEMENT AND PARTNERSHIP BUILDING TO ADDRESS ENVIRONMENTAL AND ENERGY JUSTICE ISSUES. RTI WILL PROVIDE TRANSLATION AND INTERPRETATION SERVICES WITH RESPECT TO GRANT PROGRAM AWARENESS AND APPLICATION, AWARD, AND MANAGEMENT PROCESSES TO PROVIDE PROGRAM PARTICIPANTS A MEANINGFUL OPPORTUNITY TO PARTICIPATE IN ENVIRONMENTAL AND ENERGY JUSTICE EFFORTS. RTI WILL FACILITATE FORMAL HANDS-ON TRAINING TO BUILD CAPACITY, INCLUDING STRENGTHENING HUMAN CAPITAL TO FOCUS ON ENVIRONMENTAL JUSTICE AND ENERGY JUSTICE ISSUES AND FOSTERING THIRD-PARTY 'COMMUNITY CHAMPIONS' (E.G., COMMUNITY ADVOCATES AND VOLUNTEER LEADERS) TO ENGAGE IN DECISION-MAKING PROCESS SO THEY WILL BE IN A STRENGTHENED POSITION TO PARTICIPATE IN ENVIRONMENTAL AND ENERGY JUSTICE PROGRAMS AND ADDRESS RELATED CHALLENGES. SUBRECIPIENT:THE SUB-AWARDEES WILL BE CONDUCTING CBO OUTREACH IN THEIR STATES, BEING THE PRIMARY CONDUIT FOR TECHNICAL ASSISTANCE IN THEIR RESPECTIVE STATE, AND PARTICIPATING IN REGION-WIDE TECHNICAL ASSISTANCE (TA) EVENTS.OUTCOMES:THE ANTICIPATED DELIVERABLES INCLUDE DOCUMENTATION FROM OUTREACH EFFORTS UNDERTAKEN, DESCRIPTIONS OF SERVICES PROVIDED, NUMBER OF PROGRAM PARTICIPANTS, TOOLS DEVELOPED, REPORTS ON FEEDBACK FROM PROGRAM PARTICIPANTS, PROGRAM EVALUATIONS, NUMBER OF IMPROVEMENTS MADE TO AN EJ TC TAC, AND THE NUMBER OF CLEAN ENERGY DEMONSTRATION OPPORTUNITIES IDENTIFIED. THE EXPECTED OUTCOMES INCLUDE INCREASED AWARENESS, KNOWLEDGE AND UNDERSTANDING OF GRANT AMONG UNDERSERVED COMMUNITIES, INCREASED ACCESS TO GRANT WRITING AND MANAGEMENT RESOURCES, AND AN INCREASE TO THE NUMBER AND QUALITY OF APPLICATIONS FOR FUNDING RELATED TO ENVI

ENHANCE PUBLIC SAFETY AND SECURITY IN THE TARGETED MUNICIPALITIES IN THE SIX CENTRAL REGION DEPARTMENTS OF: EI PROGRESO, ESCUINTLA JALAPA AND OTHERS

CHANGES IN LANGUAGE INCLUDED UNDER SECTION A.4 BUDGET AND IN THE PROGRAM DESCRIPTION

WITH THIS ACTIVITY, USAID SEEKS TO ADVANCE NUTRITION MONITORING, EVALUATION, RESEARCH, RESEARCH TRANSLATION, AND LEARNING TO IMPROVE THE NUTRITIONAL STATUS OF WOMEN AND CHILDREN. THE NEW ACTIVITY WILL FILL EVIDENCE GAPS TO IMPROVE NUTRITION OUTCOMES THROUGH HEALTH SYSTEMS WHILE ENSURING LOCAL PARTNERS DESIGN, IMPLEMENT, DISSEMINATE, AND USE SUCH EVIDENCE FOR POLICIES AND PROGRAMS.

DATA MANAGEMENT AND COORDINATING CENTER (DMCC) FOR THE MYALGIC ENCEPHALOMYELITIS/ CHRONIC FATIGUE SYNDROME (ME/CFS) COLLABORATIVE RESEARCH CENTERS (CRC)

SURVEY OF INMATES IN STATE AND FEDERAL CORRECTIONAL FACILITIES (SISFCF), 2012

ESTABLISHING THE PHENX TOOLKIT AS A BIOMEDICAL KNOWLEDGEBASE - PROJECT SUMMARY/ABSTRACT THE GOAL OF PHENX (CONSENSUS MEASURES FOR PHENOTYPES AND EXPOSURES) IS TO PROVIDE INVESTIGATORS WITH STANDARD MEASUREMENT PROTOCOLS (E.G., QUESTIONNAIRES, BIOASSAYS, PHYSICAL MEASUREMENTS) TO IMPROVE THE QUALITY AND CONSISTENCY OF DATA COLLECTION AND INCREASE THE IMPACT OF INDIVIDUAL STUDIES. OVER TIME, THIS COMMON CURRENCY WILL ENABLE INVESTIGATORS TO MORE EASILY COMBINE STUDIES TO INCREASE STATISTICAL POWER AND COMPARE STUDIES TO VALIDATE FINDINGS. ENABLING ANALYSIS OF SHARED DATA SHOULD LEAD TO A BETTER UNDERSTANDING OF THE ETIOLOGY, PROGRESSION, AND TREATMENT OF HUMAN DISEASE, ULTIMATELY LEADING TO IMPROVEMENTS IN PATIENT CARE, HEALTH OUTCOMES AND QUALITY OF LIFE. TO THIS END, PHENX HAS ESTABLISHED A FREELY AVAILABLE, WEB-BASED CATALOG (HTTPS://WWW.PHENXTOOLKIT.ORG/) OF MEASUREMENT PROTOCOLS INTENDED FOR USE IN GENOMIC, CLINICAL, TRANSLATIONAL, AND EPIDEMIOLOGICAL RESEARCH WITH HUMAN PARTICIPANTS. THE PHENX TOOLKIT CONTENT AND FEATURES ARE DRIVEN BY THE SCIENTIFIC COMMUNITY. THE PHENX STEERING COMMITTEE (SC) PROVIDES OVERARCHING GUIDANCE AND EACH MEASUREMENT PROTOCOL IN THE PHENX TOOLKIT IS SELECTED BY A WORKING GROUP (WG) OF EXPERTS USING A CONSENSUS-BASED PROCESS THAT RELIES ON INPUT FROM THE SCIENTIFIC COMMUNITY. INITIALLY RELEASED IN 2009, THE PHENX TOOLKIT CURRENTLY INCLUDES 874 PROTOCOLS ADDRESSING HUMAN PHENOTYPES AND EXPOSURES. IN THE NEXT 5 YEARS, PHENX WILL EXPAND THE BREADTH AND DEPTH OF THE TOOLKIT, INCREASE UTILITY, AND STRIVE TO INCREASE AWARENESS OF THE RESOURCE. THE SPECIFIC AIMS ARE TO (1) REVIEW, UPDATE, AND EXPAND PHENX TOOLKIT CONTENT; (2) LEVERAGE BIOMEDICAL STANDARDS TO INCREASE SCIENTIFIC IMPACT OF PHENX TOOLKIT; AND (3) RAISE AWARENESS AND INCREASE ADOPTION OF THE PHENX TOOLKIT. THIS RESEARCH PLAN WILL ESTABLISH THE PHENX TOOLKIT AS A SUSTAINABLE KNOWLEDGEBASE THAT ORGANIZES, ACCUMULATES, AND ANNOTATES STANDARD PROTOCOLS AND LINKS THEM TO RELEVANT RESOURCES AND DATA. THIS PLAN, WHICH REFLECTS A MULTIPRONGED APPROACH, WILL ENSURE THAT THE VALUE AND IMPACT OF THE PHENX TOOLKIT WILL CONTINUE TO INCREASE OVER TIME.

THE LEARNING, ADVANCING, UNDERSTANDING, NURTURING AND COLLABORATING HUB - THE LEARNING, ADVANCING, UNDERSTANDING, NURTURING AND COLLABORATING HUB—LAUNCH—DEVELOPED BY RTI INTERNATIONAL IN PARTNERSHIP WITH POWER TO DECIDE, HEALTHY TEEN NETWORK, SISTERLOVE, AND YOUTH COLLABORATORY, WILL ADVANCE EQUITY IN ADOLESCENT SEXUAL HEALTH BY IDENTIFYING, RECRUITING, AND PARTNERING WITH TEAMS OF INNOVATORS THAT HAVE IDENTIFIED INITIAL OR EMERGENT SOLUTIONS TO THE CURRENT GAPS IN EVIDENCE FOR PROMOTING ADOLESCENT SEXUAL HEALTH. OVER 5 YEARS, LAUNCH WILL RECRUIT AND SUPPORT AT LEAST 25 INNOVATION DEVELOPMENT TEAMS. THESE TEAMS WILL HAVE EXISTING PROTOTYPES THAT DEMONSTRATE PROMISE IN ADVANCING EQUITY IN ADOLESCENT SEXUAL HEALTH OUTCOMES. WE WILL RECRUIT AND ENGAGE DIVERSE COHORTS OF INNOVATION DEVELOPMENT TEAMS THAT INCLUDE BOTH EXISTING GRANTEES FUNDED BY THE OFFICE OF POPULATION AFFAIRS (OPA) AND TEAMS FROM COMMUNITIES THAT HAVE NOT HISTORICALLY RECEIVED INVESTMENTS IN ADOLESCENT SEXUAL HEALTH. BY INCLUDING AN INTENTIONAL FOCUS ON EQUITY THROUGHOUT THE ACCELERATOR PROCESS—RECRUITMENT, SELECTION, SUPPORT, AND LEARNING—LAUNCH WILL CONTRIBUTE TO THE PIPELINE OF EVIDENCE-BASED INTERVENTIONS THAT ARE AVAILABLE FOR FAMILIES, COMMUNITIES, AND SCHOOLS TO USE TO SUPPORT YOUNG PEOPLE AND THE ADULTS IN THEIR LIVES. OTHER KEY PROJECT ACTIVITIES WILL INCLUDE DISSEMINATING THE LEARNINGS FROM THE LAUNCH ACCELERATOR AND OUR INNOVATION DEVELOPMENT TEAMS, MONITORING AND IMPROVING THE LAUNCH ACCELERATOR, AND COLLABORATING WITH OTHER INNOVATION HUBS AND OPA GRANTEES MORE BROADLY.