Georgia State University Research Foundation Inc

THE SCIENCE OF DECISION MAKING: CONNECTING PEOPLE AND POLICY

THERAPEUTICS TARGETING FILOVIRAL INTERFERON-ANTAGONIST AND REPLICATION FUNCTIONS

CROSS-INSTITUTIONAL COLLABORATION AND REIMAGINING TOWARD EQUITY, ACCESS, AND TEACHER EFFECTIVENESS: EXPANDING AND SUSTAINING PROJECT CREATE

THE PURPOSE OF THE SEED PROGRAM IS TO INCREASE THE NUMBER OF HIGHLY EFFECTIVE EDUCATORS BY SUPPORTING THE IMPLEMENTATION OF EVIDENCE-BASED PRACTICES THAT PREPARE, DEVELOP, OR ENHANCE THE SKILLS OF EDUCATORS. THESE GRANTS WILL ALLOW ELIGIBLE APPLICANTS TO DEVELOP, EXPAND, AND EVALUATE PRACTICES THAT CAN SERVE AS MODELS TO BE SUSTAINED AND DISSEMINATED. THE SEED PROGRAM ALSO ENCOURAGES THE USE OF RIGOROUS EVIDENCE IN SELECTING AND IMPLEMENTING INTERVENTIONS TO SUPPORT EDUCATORS DEVELOPMENT ACROSS THE CONTINUUM OF THEIR CAREERS. ELEMENTARY SECONDARY EDUCATION ACT OF 1965, AS AMENDED (ESEA) (20 U.S.C. 6672) SECTION 2242

FY 2009 TEACHER QUALITY PARTNERSHIPS GRANTS

NATIONAL CENTER FOR SPECIAL RESEARCH (NCSER)

NEW COE CA "DOD CENTER OF EXCELLENCE IN ADVANCED COMPUTING AND SOFTWARE (COE-ACS)"

EDUCATION RESEARCH AND DEVELOPMENT CENTERS

STRENGTHENING THE UNIVERSITY-DISTRICT-COMMUNITY PARTNERSHIP: COMPASSION, REFLECTION AND EQUITY FOR ATLANTA TEACHER EFFECTIVENESS (CREATE)

CENTER FOR BEHAVIORAL NEUROSCIENCE

MULTIVARIATE METHODS FOR IDENTIFYING MULTI-TASK/MULTIMODAL BRAIN IMAGING BIOMARKE

MECHANISMS OF EVASION OF THE INNATE AND ADAPTIVE IMMUNE RESPONSES TO FILOVIRUSES

FIRST IN THE WORLD - VALIDATION

STARVE AND KILL: ENGINEERED ANTIGENS TARGETING NUTRIENT ACQUISITION PATHWAYS ESSENTIAL FOR GONOCOCCAL INFECTION AND DISEASE

NURTURES

CREATE (COLLABORATION AND REFLECTION TO ENHANCE ATLANTA TEACHER EFFECTIVENESS)

CENTER OF EXCELLENCE: ENVIRONMENTAL HEALTH DISPARITIES CORE

IMPLEMENTATION GRANT: COMMUNITY-SOIL-AIR-WATER (CSAW): A MODEL COMMUNITY-BASED LEARNING ECOSYSTEM TO TRANSFORM GEOSCIENCES -THE COMMUNITY-SOIL-AIR-WATER (CSAW) LEARNING ECOSYSTEM WILL INTEGRATE JUSTICE, EQUITY, DIVERSITY, AND INCLUSION INTO THE PRACTICES OF COLLABORATING WITH COMMUNITIES IN GEOSCIENCES RESEARCH. TO EXPAND CAPACITY AND ACCOUNTABILITY IN SOCIO-ENVIRONMENTAL RESEARCH COLLABORATIONS BETWEEN GEOSCIENTISTS AND COMMUNITY PARTNERS, CSAW WILL BRING TOGETHER THREE ACADEMIC PARTNERS (GEORGIA STATE UNIVERSITY, A PREDOMINANTLY BLACK INSTITUTION, SPELMAN COLLEGE, A HISTORICALLY BLACK COLLEGE, AND EMORY UNIVERSITY) WITH TWO COMMUNITY ORGANIZATIONS: THE WEST ATLANTA WATERSHED ALLIANCE AND ECO-ACTION. THIS PROJECT WILL ADDRESS THE QUESTION: HOW CAN GEOSCIENTISTS LEARN FROM, CONTRIBUTE TO, AND FIND SOLUTIONS WITH COMMUNITIES FACING FUNDAMENTAL PROBLEMS RELATED TO EARTH SYSTEMS? CSAW WILL EXAMINE HOW A LEARNING ECOSYSTEM MODEL CENTERED IN COMMUNITY-ENGAGED, PLACE-BASED RESEARCH CAN INCREASE: (1) RECRUITMENT, RETENTION, AND TRAINING OF DIVERSE GEOSCIENTISTS; AND (2) CAPACITY FOR AND ACCOUNTABILITY WITHIN COLLABORATION BETWEEN GEOSCIENTISTS AND COMMUNITIES ADDRESSING SOCIO-ENVIRONMENTAL PROBLEMS. COHORTS OF FACULTY AND COMMUNITY ORGANIZERS ALONG WITH 12 POST-BACCALAUREATE (POSTBAC) SCHOLARS AND 15 MASTER?S STUDENTS WILL BE TRAINED IN BUILDING OUTREACH AND RESEARCH PROJECTS WITH COMMUNITY PARTNERS USING A FRAMEWORK OF SHARED VALUES OF EQUITY, TRANSPARENCY, AND ACCOUNTABILITY. THESE PROJECTS WILL ADDRESS CRITICAL NEEDS IN PLACE-BASED EARTH SYSTEMS RESEARCH INCLUDING SOIL LEAD AND OTHER HEAVY METAL CONTAMINATION AND RADON EXPOSURE; AIR POLLUTION, CLIMATE CHANGE, AND HEAT MAPPING; AND WATER POLLUTION, URBAN FLOODING, AND GREEN STORMWATER INFRASTRUCTURE. THE OVERALL GOALS AND OBJECTIVES OF THE PROJECT ARE TO BUILD A BRIDGE: 1) BUILD AND FORMALIZE THE CSAW LEARNING ECOSYSTEM WITH ALL COHORT MEMBERS TO SOLVE SOCIO-ENVIRONMENTAL CHALLENGES; 2) RECRUIT DIVERSE COHORTS OF POSTBACS AND MASTER?S STUDENTS AND TRAIN THEM IN PROFESSIONAL DEVELOPMENT, COMMUNITY ENGAGEMENT, AND NETWORKING, WITH A FOCUS ON CENTERING JUSTICE, EQUITY, AND INCLUSION; 3) IMPLEMENT TRAINING, PROGRAMMING, AND PEDAGOGY PROTOCOLS TO RECRUIT, MENTOR, AND SUPPORT DIVERSE STUDENTS, COMMUNITY COLLABORATORS, AND FACULTY IN THE GEOSCIENCES; 4) DEVELOP AN ASSET-BASED MODEL OF COLLABORATION WITH COMMUNITY-DRIVEN RESEARCH TO INCLUDE FORMAL TRAINING, ACCOUNTABILITY, AND ASSESSMENT FOR ENGAGEMENT PRACTICES AND OUTCOMES; AND 5) GROW A NETWORK, MATERIALS, AND PROTOTYPE TO EXPAND THE CSAW LEARNING ECOSYSTEM MODEL TO OTHER COMMUNITIES, UNIVERSITIES, AND INSTITUTIONS. CSAW PARTNERSHIPS WILL ADVANCE A BROAD RANGE OF SCHOLARSHIP ON SOCIO-ENVIRONMENTAL PROBLEMS AND THEIR SOLUTIONS, AND ON BEST PRACTICES FOR GEOSCIENTISTS IN COMMUNITY ENGAGEMENT, ACCOUNTABILITY, AND CO-PRODUCTION. CSAW WILL PROVIDE A WELL-EVALUATED AND SUCCESSFUL MODEL TO ADOPT IN TRANSFORMATIVE GEOSCIENCES WORK ACROSS DISCIPLINES. THROUGH BROADENING PARTICIPATION OF UNDERREPRESENTED GROUPS AND BUILDING AND ENHANCING PARTNERSHIPS WITH COMMUNITY ADVOCACY GROUPS, THE CSAW LEARNING ECOSYSTEM WILL PROVIDE A PROTOTYPE TO PROMOTE GEOSCIENCE TRANSFORMATIONS AT OTHER INSTITUTIONS AND ACROSS DISCIPLINES. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

COINSTAC: DECENTRALIZED, SCALABLE ANALYSIS OF LOOSELY COUPLED DATA

AMPK AS A REDOX SENSOR AND MODULATOR

NEISSERIA GONORRHOEAE METAL TRANSPORTERS THAT SUBVERT NUTRITIONAL IMMUNITY

INNOVATIONS IN DEVELOPING RESIDENT EDUCATORS AND MENTORS

MINING THE GENOMEWIDE SCAN: GENETIC PROFILES OF STRUCTURAL LOSS IN SCHIZOPHRENIA

NOVEL INFLUENZA A NANOVACCINES FOR BROAD CROSS PROTECTION

INTERROGATING STRESS-RELIEVING NEURAL CIRCUITS TO ALLEVIATE CARDIOVASCULAR DISEASE

IDENTIFICATION AND PRE-CLINICAL EVALUATION OF MEASLES VIRUS INHIBITORS

LEADERSHIP EDUCATION IN NEURODEVELOPMENTAL AND RELATED DISORDERS TRAINING PROGRAM

PATHOPHYSIOLOGY OF TLR5KO COLITIS

CREST CENTER FOR DYNAMIC MULTISCALE AND MULTIMODAL BRAIN MAPPING OVER THE LIFESPAN [D-MAP]

DEVELOPMENT OF A BROAD-SPECTRUM INHIBITOR AGAINST SEASONAL AND HIGHLY-PATHOGENIC INFLUENZA VIRUSES

AMP-ACTIVATED KINASE IN DIABETIC COMPLICATIONS

DECONSTRUCTING INFLAMMATION AND ALTERED MICROBIOTA IN METABOLIC SYNDROME

EXPLORING THE MILLIARCSECOND FRONTIER: OPEN ACCESS TO THE RENEWED CHARA ARRAY

NEURONS EXPRESSING ANGIOTENSIN TYPE 2 RECEPTORS IN THE NTS AS AN ACCESS POINT FOR CARDIOVASCULAR CONTROL.

ADVANCING INNOVATIVE PARTNERSHIPS AND PATHWAYS TO ADDRESS MENTAL HEALTH WORKFORCE SHORTAGES IN GEORGIA SCHOOLS

LEADERSHIP EDUCATION IN NEURODEVELOPMENTAL AND RELATED DISORDERS TRAINING PROGRAM

NOVEL NONLINEAR OPTICAL PROCESSES IN ACTIVE, RANDOM AND NANOSTRUCTURED SYSTEMS

TEACHER QUALITY ENHANCEMENT GRANTS FOR STATE AND PARTNERSHIPS - PARTNERSHIP GRANTS

NEUROCOGNITIVE BASES OF TREATMENT RESISTANCE IN DEVELOPMENTAL DYSLEXIA

REACTIVE NITROGEN AND ACCELERATED ATHEROSCLEROSIS IN TYPE I DIABETES

INFLUENZA VACCINES INDUCING BROADLY CROSS PROTECTIVE IMMUNITY

INFANT-TODDLER COURT PROGRAM - CENTER OF EXCELLENCE FOR CHILDREN’S BEHAVIORAL HEALTH GEORGIA HEALTH POLICY CENTER GEORGIA STATE UNIVERSITY 55 PARK PLACE, ATLANTA, GA 30303 (404) 413-0314 HTTPS://GACOEONLINE.GSU.EDU/ PROJECT DIRECTOR: ANN MUKHERJEE, MPP EMAIL ADDRESS: AHEDGES@GSU.EDU THE CENTER OF EXCELLENCE FOR CHILDREN’S BEHAVIORAL HEALTH (COE OR CENTER) IS SEEKING HRSA FUNDING OPPORTUNITY HRSA-22-073, INFANT-TODDLER COURT PROGRAM – STATE AWARD. THE CENTER IS SEEKING $625,000 PER YEAR FOR A 5-YEAR PROJECT PERIOD. THE CENTER PROPOSES A 5-YEAR PROJECT BEGINNING WITH A YEARLONG PLANNING PHASE TO DEVELOP AN INFANT-TODDLER COURT (ITC) LEADERSHIP TEAM AND STATEWIDE ACTION PLAN THAT WILL GUIDE 4 YEARS OF ITC IMPLEMENTATION. DURING IMPLEMENTATION, THE COE WILL INITIATE 3 ITC TEAMS IN LOCAL JURISDICTIONS THROUGH A REQUEST FOR APPLICATIONS (RFA) PROCESS AND PROVIDE STATEWIDE LEADERSHIP AND COORDINATION TO INCREASE CAPACITY FOR AND KNOWLEDGE OF THE ITC APPROACH ACROSS THE STATE. THE GOAL OF GEORGIA’S INFANT-TODDLER COURT (ITC) PROGRAM IS TO IMPROVE STATEWIDE SYSTEMS AND POLICIES TO SUPPORT YOUNG CHILDREN (AGES 0-3) AND THEIR FAMILIES WHO ARE INVOLVED, OR AT RISK OF INVOLVEMENT, WITH THE CHILD WELFARE SYSTEM, AND BUILD CAPACITY TO PREVENT CHILD MALTREATMENT MORE BROADLY. THE STATE WILL ACHIEVE THIS GOAL BY EXPANDING EVIDENCE-BASED INFANT-TODDLER COURT TEAMS AND IMPROVING EARLY DEVELOPMENTAL HEALTH AND WELL-BEING OF INFANTS, TODDLERS, AND THEIR FAMILIES BY COMPLETING THE FOLLOWING OBJECTIVES: ESTABLISH LEADERSHIP CAPACITY IN GEORGIA TO INFORM ITC IMPLEMENTATION THROUGH THE CREATION AND TRAINING OF A STATE-LEVEL ITC LEADERSHIP TEAM. THE LEADERSHIP TEAM WILL INCLUDE STATE-LEVEL PARTNERS, LOCAL LEADERS, AND FAMILIES WITH LIVED EXPERIENCE. DEVELOP A STATE ACTION PLAN TO GUIDE ITC IMPLEMENTATION IN THE STATE THROUGH A SYSTEMATIC PROCESS LED BY THE STATE-LEVEL ITC LEADERSHIP TEAM AND INVOLVING THE ITC NATIONAL RESOURCE CENTER, RELEVANT STAKEHOLDERS, AND FAMILIES WITH LIVED EXPERIEN CE. INCREASE CAPACITY THROUGH TRAINING OF STATE AND LOCAL PARTNERS IN THE ITC APPROACH AND TOPICS RELATED TO THE DEVELOPMENTAL HEALTH, MENTAL HEALTH, AND WELL-BEING OF VERY YOUNG CHILDREN. ESTABLISH LOCAL CAPACITY FOR ITC IMPLEMENTATION BY ESTABLISHING THREE LOCAL ITC SITES THROUGH A REQUEST FOR APPLICATIONS PROCESS INFORMED BY THE STATE ACTION PLAN, ITC LEADERSHIP TEAM, AND FAMILIES WITH LIVED EXPERIENCE. IMPROVE YOUTH AND FAMILY OUTCOMES DURING AND AFTER CHILD WELFARE AND/OR COURT INVOLVEMENT DEMONSTRATED THROUGH COLLECTION AND EVALUATION OF PROGRAM OUTCOMES DATA AT THE THREE LOCAL ITC SITES. ESTABLISH SUSTAINABILITY AND SCALING PLANS UTILIZING EVALUATION DATA AND LEARNINGS FROM IMPLEMENTATION TO INFORM SUSTAINABILITY AND FUTURE SCALING OF THE MODEL ACROSS GEORGIA. THE COE IS POSITIONED TO LEAD THIS WORK GIVEN ITS CURRENT LEADERSHIP IN STATEWIDE INITIATIVES BUILDING INFANT AND EARLY CHILDHOOD SYSTEMS OF CARE AND DEVELOPING SYSTEMS OF CARE FOR CHILDREN WITH BEHAVIORAL HEALTH NEEDS. THE CENTER HAS ESTABLISHED MULTI-SECTOR AND CROSS-AGENCY PARTNERSHIPS THROUGHOUT THE STATE, INCLUDING CONNECTIONS AND ENGAGEMENT WITH FAMILIES WHO HAVE LIVED EXPERIENCE NAVIGATING SERVICES FOR THEIR YOUNG CHILDREN ACROSS MULTIPLE STATE AGENCIES. THE COE AND ITS PARTNERS RECOGNIZE THE INCREDIBLE IMPORTANCE OF THE PRENATAL TO 3 PERIOD OF LIFE. THIS FOUNDATION OF COMMON UNDERSTANDING THAT YOUNG CHILDREN HAVE UNIQUE DEVELOPMENTAL NEEDS IS A STRENGTH OF THE STATE PARTNERS AND WILL HELP THE LEADERSHIP TEAM TRANSITION QUICKLY FROM KICK-OFF TO PLANNING AND IMPLEMENTATION.

ADDRESSING SOCIAL DETERMINANTS OF HEALTH IN THE MOST DIVERSE SQUARE MILE IN AMERICA

STRUCTURE-BASED DESIGN OF CORONAVIRUS SUBUNIT VACCINES

RESEARCH IN HEAVY ION NUCLEAR REACTIONS

RATIONAL DESIGN AND EVALUATION OF NOVEL MRNA VACCINES AGAINST MERS-COV

BIOBEHAVIORAL FOUNDATIONS AND DEVELOPMENT OF COGNITIVE COMPETENCE

INTESTINAL MICROBIOTA-MEDIATED ROTAVIRUS VACCINE FAILURE - PROJECT SUMMARY INFECTION OF GUT EPITHELIA BY ATTENUATED ROTAVIRUS (RV) VACCINES SERVES TO PROTECT MILLIONS OF LIVES ANNUALLY. IT IS INCREASINGLY APPRECIATED THAT GUT MICROBIOTA, WHICH SHAPE THE MILIEU IN WHICH ROTAVIRUSES ENCOUNTER THE EPITHELIUM IS A PIVOTAL DETERMINANT OF ROTAVIRUS VACCINE EFFICACY. INDEED, RV VACCINES HAVE PROVEN TO BE MUCH LESS EFFECTIVE IN DEVELOPING COUNTRIES WHICH ARE KNOWN TO HAVE STARK DIFFERENCES IN GUT MICROBIOTA COMPOSITION. OUR PUBLISHED WORK DEMONSTRATES THAT MICROBIOTA CAN BOTH DIRECTLY IMPACT RV AND, MOREOVER, IMPACT GUT EPITHELIA TO PREVENT AGAINST ITS ENTRY AND REPLICATION. FURTHERMORE, OUR UNPUBLISHED WORK COMPELLINGLY ARGUES FOR A CENTRAL ROLE FOR GUT MICROBIOTA COMPOSITION IN RV VACCINE INEFFICACY. SPECIFICALLY, WE FIND THAT TRANSPLANT OF MICROBIOTA FROM NON-RV VACCINE RESPONDING CHILDREN CONFERS A MICROBIOTA-DEPENDENT NON-RESPONDER PHENOTYPE. IN ADDITION, CULTURING INFANT FECAL SAMPLES IN BIOREACTOR CONTINUOUS CULTURE SYSTEMS YIELDS SUPERNATANTS THAT DIFFERENTIALLY INHIBIT RV VACCINE REPLICATION IN VITRO. HENCE, THE CENTRAL GOALS OF THIS PROPOSAL ARE TO IDENTIFY AND ISOLATE MICROBIOTA CONSTITUENTS THAT DRIVE RV VACCINE INEFFICACY IN HUMANS AND DETERMINE MECHANISMS BY WHICH THEY ACT. FINDINGS FROM THIS WORK WILL ADVANCE OUR FUNDAMENTAL KNOWLEDGE ON BACTERIAL-VIRAL INTERACTIONS IN THE GUT, MECHANISTICALLY ENLIGHTEN HOW MICROBIOTA CAN IMPACT REPLICATION AND RESPONSE TO LIVE, ATTENUATED ORAL VACCINES AND POTENTIALLY AID IN THE DEVELOPMENT OF NOVEL STRATEGIES TO REDUCE THE BURDEN OF ENTERIC VIRAL INFECTIONS.

ENABLING MILLIARCSECOND ASTROPHYSICS: OPEN ACCESS FOR THE CHARA ARRAY

NOVEL NANOBODIES TO PREVENT AND TREAT SARS-COV-2 AND OTHER PATHOGENIC HUMAN CORONAVIRUSES

MULTIVALENT NANOCLUSTER UNIVERSAL INFLUENZA VACCINE GIVEN BY MICRONEEDLE PATCH

ENHANCING SAFETY AND WELL-BEING OF CHILDREN OF ADULT DRUG COURT PARTICIPANTS

COMMUNICATING ABOUT NICOTINE AND DIFFERENTIAL RISKS OF TOBACCO PRODUCTS

VLP VACCINE TECHNOLOGY

DATA DRIVEN DYNAMIC ACTIVITY/CONNECTIVITY METHODS FOR EARLY DETECTION OF ALZHEIMER?S - PROJECT SUMMARY/ABSTRACT THE DEVELOPMENT OF BIOMARKERS FOR IDENTIFYING PRECLINICAL OR PRODROMAL ALZHEIMER’S DISORDER ARE OF GREAT IN- TEREST. WHILE SOME INITIAL RESULTS BASED ON RESTING FMRI HAVE BEEN PRESENTED, ACCURACY, ROBUSTNESS, AND RELIA- BILITY ARE STILL RELATIVELY LOW. ONE HIGHLY PROMISING DIRECTION IS THE DEVELOPMENT OF DYNAMIC FUNCTIONAL ACTIVITY AND FUNCTIONAL CONNECTIVITY APPROACHES. THESE APPROACHES HAVE BEEN SHOWN TO BE ESPECIALLY PROMISING MOST LIKELY DUE TO THE HIGHLY DYNAMIC NATURE OF THE BRAIN AND THE UNCONSTRAINED NATURE OF RESTING FMRI. CURRENTLY, THERE ARE NO METHODS THAT CAN PROVIDE A FULL CHARACTERIZATION OF TEMPORAL, SPATIAL, AND SPATIO-TEMPORAL DYNAMICS NOR CAN MOST EXISTING APPROACHES CHARACTERIZE HETEROGENOUS SUBGROUPS OR COMPLEX MULTISCALE RELATIONSHIPS. WE WILL DEVELOP NEW METHODS THAT CAN EFFECTIVELY CAPTURE DYNAMIC CONNECTIVITY AND PROVIDE SUMMARY METRICS WITH A FOCUS ON INDIVIDUALIZED PREDICTION OF ALZHEIMER’S DISEASE WELL PRIOR TO THE ONSET OF THE ILLNESS. WE PROPOSE A NOVEL FAMILY OF MODELS THAT BUILDS ON THE WELL-STRUCTURED FRAMEWORK OF JOINT BLIND SOURCE SEPARATION TO CAPTURE A MORE COMPLETE CHARACTERIZATION OF (POTENTIALLY NONLINEAR) SPATIO-TEMPORAL DYNAMICS. OUR MODELS WILL ALSO PRO- DUCE A RICH SET OF METRICS TO CHARACTERIZE THE AVAILABLE DYNAMICS AND ENABLE IN DEPTH COMPARISON WITH CURRENTLY AVAILABLE MODELS. WE SHOW EVIDENCE THAT SUCH MEASURES ARE LIKELY TO BE CONSIDERABLY MORE SENSITIVE AND MORE ACCURATE IN CLASSIFYING INDIVIDUALS. WE WILL EXTENSIVELY VALIDATE OUR APPROACHES IN A VARIETY OF WAYS INCLUDING SIMULATIONS, CONCURRENT EEG/FMRI DATA, AND EVALUATION ON A LARGE NORMATIVE DATA SET. WE WILL APPLY THE DEVEL- OPED METHODS TO SEVERAL LARGE DATASETS INCLUDING A LARGE LONGITUDINAL SAMPLE OF INDIVIDUALS WHO HAVE BEEN SCANNED AT EMORY UNIVERSITY WITH RESTING FMRI WHO ALSO HAVE CSF AMYLOID AND TAU PET MEASURES. WE WILL USE THE DEVELOPED MARKERS TO PREDICT COGNITIVE DECLINE, AMYLOID, AND TAU LEVELS IN THESE DATA AND INCLUDE BOTH A DISCOVERY DATA SET AS WELL AS AN INDEPENDENT REPLICATION DATA SET. SUCCESSFUL COMPLETION OF OUR AIMS WILL BE AN IMPORTANT FIRST STEP TOWARDS PROVIDING AN OPPORTUNITY TO DEVELOP AND EVALUATE INTERVENTIONS EARLY ENOUGH TO HAVE A POSITIVE IMPACT ON LONG-TERM PROGNOSIS. WE WILL PROVIDE OPEN SOURCE TOOLS AND RELEASE DATA THROUGHOUT THE DURATION OF THE PROJECT VIA GITHUB, A WEB PORTAL AND THE NITRC REPOSITORY, HENCE ENABLING OTHER INVESTIGATORS TO COMPARE THEIR OWN METHODS WITH OUR OWN AS WELL AS TO APPLY THEM TO A LARGE VARIETY OF BRAIN DISORDERS. OUR TOOLS ALSO HAVE WIDE APPLICATION TO THE STUDY OF THE HEALTHY BRAIN AS WELL AS MANY OTHER DISEASES. 37

MALE/FEMALE DIFFERENCES IN PSYCHOSIS AND MOOD DISORDERS:DYNAMIC IMAGING-GENOMIC MODELS FOR CHARACTERIZING AND PREDICTING PSYCHOSIS AND MOOD D

GRADUATE PSYCHOLOGY EDUCATION PROGRAMS

POLYMERASE INHIBITORS OF RESPIRATORY SYNCYTIAL VIRUS

MEANINGFUL ENGAGEMENT AND QUALITY OF LIFE AMONG ASSISTED LIVING RESIDENTS WITH DEMENTIA

ASSESSING THE INTENDED AND UNINTENDED CONSEQUENCES OF E-CIGARETTE TV ADVERTISING

CONTROLLING VSMC PROLIFERATION AND MIGRATION

EXAMINING CARBON MONOXIDE TO TREAT INFLAMMATORY CONDITIONS USING EXPERIMENTAL COLITIS MODELS

GEORGIA STATE PHYSICAL ACTIVITY AND NUTRITION PROGRAM (G-SPAN) - THOUGH SIGNIFICANT INVESTMENTS AND PROGRESS HAVE BEEN MADE IN NUTRITION AND PHYSICAL ACTIVITY, HEALTH DISPARITIES PERSIST IN OBESITY PREVALENCE, CHRONIC DISEASE PREVALENCE, PHYSICAL FITNESS, FOOD AND NUTRITION SECURITY, BREASTFEEDING PREVALENCE, AND EARLY CARE AND EDUCATION ACROSS GEORGIA. THIS PROPOSAL DETAILS A PLAN TO EXPAND EXISTING INITIATIVES AND ESTABLISH NEW POLICY, SYSTEMS AND ENVIRONMENTAL (PSE) STRATEGIES AND ACTIVITIES IN THE STATE OF GEORGIA THAT WILL IMPROVE THE CAPACITY OF STATE, REGIONAL, AND LOCAL AGENCIES TO ADDRESS THESE DISPARITIES EFFECTIVELY. THE PLAN STRATEGIES FOCUS ON NUTRITION, PHYSICAL ACTIVITY, BREASTFEEDING, AND EARLY CARE EDUCATION OBESITY PREVENTION/FARM TO EARLY CARE. SPECIFICALLY, THIS PROPOSAL SEEKS TO ADDRESS INEQUITIES IN EACH OF THESE AREAS WITHIN PRIORITY POPULATIONS IN SELECT GEOGRAPHIC REGIONS OF GEORGIA. BY BRINGING TOGETHER VARIOUS STATE AND LOCAL PARTNERS, INCLUDING THE VOICE OF COMMUNITIES IMPACTED BY THESE DISPARITIES, THIS PROPOSAL WILL STRENGTHEN EXISTING PARTNERSHIPS AND EXPAND THEIR CAPACITY TO ACHIEVE IMPROVED HEALTH OUTCOMES. WITH EXTENSIVE EXPERIENCE IN SUPPORTING STATE LEVEL PSE CHANGE, PROGRAM DEVELOPMENT AND COLLECTIVE IMPACT EVALUATION, THE GEORGIA HEALTH POLICY CENTER (GHPC) LOCATED AT 55 PARK PLACE NE, 8TH FLOOR, ATLANTA, GA 30303, WILL ACT AS THE BACKBONE ORGANIZATION FOR THIS COOPERATIVE AGREEMENT. IN CLOSE PARTNERSHIP WITH STATE AND LOCAL AGENCIES, SUCH AS THE GEORGIA DEPARTMENTS OF PUBLIC HEALTH (GDPH) AND EARLY CARE AND LEARNING (DECAL), WHOLESOME WAVE GEORGIA, GA CHAPTER-AMERICAN ACADEMY OF PEDIATRICS/GA BREASTFEEDING COALITION, HEALTHMPOWERS, AND CHILDREN’S HEALTHCARE OF ATLANTA/STRONG4LIFE, WE SEEK TO IMPROVE OUTCOMES IN EACH OF THE 4 STRATEGY AREAS. EXAMPLES OF THESE OUTCOMES INCLUDE: NUTRITION OUTCOMES - INCREASED NUMBER OF YOUTH/CHILD-SERVING AND COMMUNITY-BASED OUT OF SCHOOL TIME SETTINGS THAT ADOPT NUTRITION GUIDELINES TO SUPPORT INCREASED ACCESS TO HEALTHIER FOODS - INCREASED UPTAKE AND EXPANSION OF GEORGIA FRESH FOR LESS VOUCHER REDEMPTION - INCREASED NUMBER OF HEALTH SYSTEMS AND HEALTH CLINICS THAT ADOPT PRODUCE PRESCRIPTION PROGRAMS PHYSICAL ACTIVITY OUTCOMES - INCREASED POLICIES, PLANS, OR COMMUNITY DESIGN CHANGES THAT INCREASE ACCESS TO PA - BUILT ENVIRONMENT INTERVENTION APPROACHES ADOPTED THAT CONNECT ACTIVITY-FRIENDLY ROUTES TO EVERYDAY DESTINATIONS TO INCREASE PA - INDIVIDUALS AND COMMUNITIES ENROLLED IN ACTIVE PEOPLE, HEALTHY NATIONSM INITIATIVE BREASTFEEDING OUTCOMES - INCREASED ACCESS TO PROGRAMS THAT PROVIDE CONTINUITY OF CARE FOR BF FAMILIES - REGIONAL BF COALITIONS AND CADRE OF BF CHAMPIONS ESTABLISHED WHO COALESCE AROUND A COMMON AGENDA, STATE PLAN CREATION, AND COLLABORATE ON INTEGRATED AND REINFORCING ACTIVITIES ACROSS REGIONS - REPLICATE EXISTING PATHWAY 2 ACADEMIC PROGRAM FOR PRE-SERVICE HUMAN LACTATION PROFESSIONALS AT 1 HBCU AND 1 UNIVERSITY TO PREPARE IBCLCS EARLY CARE EDUCATION OUTCOMES - INCREASED STATE LEVEL ECE POLICIES AND ACTIVITIES THAT IMPROVE NUTRITION, PA, BR AND FARM TO ECE INCLUDING ESTABLISHED QRIS STANDARDS AND MEASURES FOR EACH STRATEGIES - GEORGIA FTECE PROVIDER NETWORK ESTABLISHED AS A HUB FOR CHILD CARE PROVIDERS TO ACCESS FTECE RELATED RESOURCES, TRAINING OPPORTUNITIES, AND TA SUPPORT - IMPROVED KNOWLEDGE AND ADOPTION OF FTECE STRATEGIES IN ECE SITES IN TARGET GEOGRAPHIC REGIONS & COMPLETION OF GFTECE STRATEGIC PLAN OBJECTIVES STATEWIDE BEYOND THE 4 STRATEGY AREAS OUTLINED, THIS PROPOSAL WILL ALSO SEEK TO IMPROVE THE CAPACITY AND ABILITY OF PARTNERS IN TARGET REGIONS OF GA IMPLICATED BY HEALTH INEQUITIES TO ADOPT PSE CHANGE THROUGH REGIONAL CAPACITY BUILDING GRANTS. A COLLECTIVE IMPACT EVALUATION FRAMEWORK WILL BE EMPLOYED TO UNDERSTAND CONTEXTS AND MECHANISMS THAT SUPPORT REGIONAL PSE AND BEHAVIOR CHANGE. QUALITY IMPROVEMENT WILL BE FACILITATED VIA A COMMUNITY-LED MONITORING LEARNING AND ADAPTATION (CLM) FRAMEWORK TO SUPPORT MODIFICATIONS TO PSE STRATEGIES AND ACTION PLANS TO ACHIEVE IDENTIFIED OUTCOMES.

EARLY-STAGE PRECLINICAL VALIDATION OF CARBON MONOXIDE PRODRUGS FOR ACUTE KIDNEY INJURY - IN RESPONSE TO PAR-19-294 (EARLY-STAGE PRECLINICAL VALIDATION OF THERAPEUTIC LEADS FOR DISEASES OF INTEREST TO THE NIDDK), WE PROPOSE TO CONDUCT PRECLINICAL VALIDATION OF CARBON MONOXIDE (CO) AS A THERAPEUTIC AGENT FOR TREATING ACUTE KIDNEY INJURY (AKI), WHICH AFFLICTS A LARGE NUMBER OF PATIENTS WITH SERIOUS AND SOMETIMES FATAL CONSEQUENCES. CURRENTLY, THERE ARE NO TREATMENT OPTIONS AVAILABLE OTHER THAN MAINTENANCE THERAPY. THEREFORE, DEVELOPING DISEASE MODIFYING TREATMENT FOR AKI WILL ADDRESS AN IMPORTANT, UNMET MEDICAL NEED. THE PROPOSED WORK OF DEVELOPING CO-BASED THERAPEUTICS IS BASED ON CO’S ENDOGENOUS SIGNALING ROLES, THE AVAILABILITY OF A LARGE AMOUNT OF LITERATURE EVIDENCE TO SHOW CO’S CYTO- AND ORGAN-PROTECTIVE EFFECTS, OUR UNIQUE CHEMISTRY WORK TO PACK “CO IN A PILL” THROUGH INNOVATIVE PRODRUG DESIGN FOR EASY DELIVERY THROUGH PHARMACEUTICALLY ACCEPTABLE FORMS, AND OUR OWN EXTENSIVE PRELIMINARY RESULTS IN DEMONSTRATING THE ORGAN-PROTECTIVE EFFECTS OF SUCH CO PRODRUGS IN ANIMAL MODELS OF KIDNEY ISCHEMIA REPERFUSION INJURY AND RHABDOMYOLYSIS INJURIES, LIVER INJURY, SYSTEMIC INFLAMMATION, AND GI INFLAMMATION SUCH AS THE COLON AND STOMACH, AMONG OTHERS. IN THIS APPLICATION, WE PROPOSE TO EXAMINE SOME KEY PRECLINICAL VALIDATION ISSUES AND AIM TO PRODUCE ONE OR MORE LEAD COMPOUNDS READY FOR IND-ENABLING WORK BY THE END OF THE GRANT PERIOD. A VERY IMPORTANT ASPECT IS OUR PLAN TO USE MULTIPLE ANIMAL MODELS INCLUDING THE EXAMINATION IN LARGE ANIMALS SUCH AS PIG TO CONDUCT THE PHARMACOLOGICAL ASSESSMENT, WHICH SHOULD GIVE ENHANCED CHANCE OF SUCCESS WHEN TRANSLATING INTO HUMAN. SPECIFICALLY, WE PROPOSE TO PURSUE THE FOLLOWING SPECIFIC AIMS (1) DESIGN, SYNTHESIS, AND ASSESSMENT OF CO PRODRUGS, (2) THERAPEUTIC VALIDATION OF CO PRODRUG EFFICACY IN MOUSE MODELS OF AKI, AND (3) THERAPEUTIC VALIDATION OF CO PRODRUGS IN PIG MODELS OF AKI. THE PROPOSED WORK WILL BRIDGE THE GAP BETWEEN OUR LONG-TERM GOAL OF DEVELOPING CO-BASED THERAPEUTICS AND THE NEED FOR PRECLINICAL ASSESSMENTS. UPON COMPLETION OF THE PROJECT, WE WILL HAVE DEVELOPED AND FULLY VALIDATED THE EFFICACY OF A SERIES OF INNOVATIVE CO PRODRUGS THAT CAN EITHER DELIVER CO SYSTEMICALLY OR SELECTIVELY TARGET THE KIDNEY AND ALLOW FOR RENAL ENRICHMENT. FURTHER, WE WILL ALSO HAVE DEVELOPED A PIPELINE FOR BACKUP CANDIDATES. COLLECTIVELY, THE PROPOSED WORK WILL BE A MAJOR STEP IN DEVELOPING CO-BASED THERAPEUTICS AGAINST AKI AND OTHER FORMS OF ORGAN INJURY.

CRCNS: MOLECULAR AND COMPUTATIONAL DISSECTION OF COLD NOCICEPTION

HIGH ANGULAR RESOLUTION COMMUNITY SCIENCE AT THE CHARA ARRAY -THE CENTER FOR HIGH ANGULAR RESOLUTION ASTRONOMY (CHARA) ARRAY IS THE NATION?S PREMIER FACILITY FOR LONG BASELINE OPTICAL INTERFEROMETRY. WITH THE NUMBER AND SIZE OF ITS TELESCOPES, THE LENGTH OF ITS BASELINES, AND THE RANGE OF WAVELENGTHS COVERED BY ITS BEAM COMBINERS, THE CHARA ARRAY IS A UNIQUELY POWERFUL FACILITY FOR MILLIARCSECOND IMAGING. WITH ADAPTIVE OPTICS AND FOUR NEW BEAM COMBINERS, THE ARRAY IS REACHING DEEPER THAN EVER. SINCE 2004 CHARA RESULTS HAVE APPEARED IN SOME 245 PAPERS IN THE REFEREED LITERATURE. THIS INCLUDES OBSERVATIONS OBTAINED DURING THE HIGH-DEMAND OPEN ACCESS PROGRAM SUPPORTED BY NSF FOR SOME YEARS, AND OPERATED IN COLLABORATION WITH NSF?S NATIONAL OPTICAL-INFRARED RESEARCH LABORATORY. THIS AWARD EXTENDS THAT PROGRAM FOR ANOTHER THREE YEARS, AND INCLUDES A NEW SNAPSHOT IMAGING MODE. THE TEAM ALSO PLANS TO OFFER USER SUPPORT, COMMUNITY WORKSHOPS, AND AN ACCESSIBLE DATA ARCHIVE. CHARA WILL FOSTER COLLABORATIONS WITH AMATEUR ASTRONOMERS THROUGH THE AMERICAN ASSOCIATION OF VARIABLE STAR OBSERVERS. CHARA TRAINS GRADUATE STUDENTS TO BUILD AND USE PRECISION TECHNOLOGY. THE CHARA ARRAY ACHIEVES SUB-MILLIARCSECOND RESOLUTION AT VISIBLE AND NEAR-INFRARED WAVELENGTHS, AND CAN BE USED TO RESOLVE THE RADII OF STARS ALL ALONG THE MAIN SEQUENCE AND AT DIFFERENT STAGES AS STARS EVOLVE OFF THE MAIN SEQUENCE. THE ARRAY REVEALS THE IMPACT OF LIMB- AND GRAVITY-DARKENING, THE SPATIAL DISTRIBUTION AND SIZE OF STAR-SPOTS AND ACTIVITY IN CONVECTION ZONES, AND PROVIDES PHYSICAL PROPERTIES OF EXOPLANET HOST STARS. THE CHARA ARRAY RESOLVES BINARY STARS, MAPS ORBITS, AND PROBES INTERACTING SYSTEMS. EXTRAGALACTIC OBSERVATIONS PROBE THE STRUCTURE OF ACTIVE GALACTIC NUCLEI CORES TO SHOW HOW SUPERMASSIVE BLACK HOLES IMPACT ACCRETION AND TRIGGER OUTFLOWS. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

WRITING IN ADULT SECONDARY EDUCATION CLASSES (W-ASE)

(SURI) SPACE DOMAIN AWARENESS IN A PHOTON-STARVED ENVIRONMENT (SDAPSE)

IMPROVING THE HEALTH OF PEOPLE WITH INTELLECTUAL/DEVELOPMENTAL DISABILITIES AND MOBILITY LIMITATIONS IN GEORGIA - NEARLY 28% OF ADULTS LIVING IN GEORGIA HAVE SOME TYPE OF DISABILITY. GEORGIANS WITH INTELLECTUAL ANDDEVELOPMENTAL DISABILITIES (IDD) AND THOSE WITH MOBILITY LIMITATIONS (ML) EXPERIENCE PROFOUND HEALTHDISPARITIES COMPARED TO ADULTS WITHOUT DISABILITIES. THEY ARE MORE LIKELY TO REPORT HAVING POOR OR FAIR HEALTH,EXPERIENCE A DISPROPORTIONATE BURDEN OF PREVENTABLE CHRONIC CONDITIONS, AND REPORT SIGNIFICANTLY MOREMENTALLY UNHEALTHY DAYS COMPARED TO ADULTS WITHOUT DISABILITIES. THESE DISPARITIES ARE INFLUENCED BY ANUMBER OF POLICY, SYSTEM, AND ENVIRONMENTAL FACTORS, INCLUDING LACK OF ACCESS TO ADEQUATELY TRAINEDHEALTHCARE PROVIDERS AND FINANCIAL BARRIERS TO RECEIVING CARE. DESPITE INCREASING EFFORTS TO ADDRESS DISABILITYHEALTH DISPARITIES AT THE NATIONAL LEVEL, COORDINATED AND CONTEXT-SPECIFIC EFFORTS TO REDUCE HEALTHINEQUITIES FOR PEOPLE WITH DISABILITIES LIVING IN GEORGIA HAVE NOT BEEN REALIZED.IN THIS APPLICATION, THE CENTER FOR LEADERSHIP IN DISABILITY AT GEORGIA STATE UNIVERSITY DESCRIBES ACOMPREHENSIVE PLAN TO REDUCE HEALTH DISPARITIES AMONG ADULTS WITH IDD AND ADULTS WITH ML INGEORGIA. THROUGH A COOPERATIVE AGREEMENT WITH THE CENTERS FOR DISEASE CONTROL AND PREVENTION, NATIONALCENTER ON BIRTH DEFECTS AND DEVELOPMENTAL DISABILITIES, WE PROPOSE TO:1) ESTABLISH, EXPAND, AND ENHANCE PARTNERSHIPS WITH STATEWIDE AND NATIONAL PARTNERS;2) CONDUCT NEEDS ASSESSMENTS TO IDENTIFY GAPS IN ACCESSIBLE PREVENTIVE HEALTH CARE AND HEALTHPROMOTION SERVICES AVAILABLE TO ADULTS WITH IDD AND ADULTS WITH ML;3) ADMINISTER AND EVALUATE A TRAINING FOR HEALTHCARE PROVIDERS ON ACCESSIBLE HEALTH CARE;4) IMPLEMENT AND EVALUATE A DEMONSTRATION PROJECT TO LINK ADULTS WITH IDD TO ACCESSIBLE PREVENTIVEHEALTH CARE AND HEALTH PROMOTION PROGRAMS IN THEIR COMMUNITIES;5) IMPLEMENT AND EVALUATE EVIDENCE-BASED HEALTH PROMOTION INTERVENTIONS AND POLICY, SYSTEMS, ANDENVIRONMENTAL CHANGES; AND6) DISSEMINATE KEY FINDINGS AND LESSONS LEARNED.SEVERAL OF THE STRATEGIES DESCRIBED ABOVE WILL B E DESIGNED IN PARTNERSHIP WITH OTHER STATE DISABILITY ANDHEALTH PROGRAMS AND IMPLEMENTED WITH A NUMBER OF GEORGIA COLLABORATORS. WE WILL SCALE THESE STRATEGIESAND ACTIVITIES STATEWIDE USING A PHASED IMPLEMENTATION APPROACH TO FACILITATE CONTINUOUS PROGRAMQUALITY IMPROVEMENT AND SUPPORT PROGRAM SUSTAINABILITY.EXPECTED OUTCOMES TO BE ACHIEVED DURING THE PERIOD OF PERFORMANCE INCLUDE STRENGTHENEDENGAGEMENT WITH STATE AND NATIONAL PARTNERS; INCREASED KNOWLEDGE OF DISPARITIES AND NEEDS AT THESTATEWIDE AND HEALTH DISTRICT LEVELS; INCREASED COMPETENCY AMONG HEALTHCARE PROVIDERS TO SERVE ADULTS WITHIDD AND ADULTS WITH ML; INCREASED KNOWLEDGE AMONG ADULTS WITH IDD ABOUT PREVENTIVE HEALTHCARE ANDHEALTH BEHAVIORS, AND BARRIERS TO RECEIVING HEALTH CARE AND ENGAGING IN HEALTH BEHAVIORS; INCREASEDENGAGEMENT IN HEALTH PROMOTION PROGRAMS AMONG ADULTS WITH IDD AND ADULTS WITH ML; INCREASED POLICY,SYSTEM, AND ENVIRONMENTAL CHANGES IMPLEMENTED AT THE STATE AND HEALTH DISTRICT LEVELS; AND INCREASEDKNOWLEDGE AMONG HEALTH PROFESSIONALS AND POLICYMAKERS ABOUT WAYS TO IMPROVE DISABILITY HEALTH EQUITY.BEYOND THE PERIOD OF PERFORMANCE, IMPLEMENTING AND EVALUATING OUR PROPOSED PLAN WILL RESULT IN ANINCREASED NUMBER OF PROVIDERS THAT CAN OFFER ACCESSIBLE PREVENTIVE HEALTH CARE, AND FEWER UNMETPREVENTIVE HEALTH CARE NEEDS, IMPROVED HEALTH BEHAVIORS, AND REDUCED PREVALENCE OF CHRONIC CONDITIONSAND RISK FACTORS AMONG ADULTS WITH IDD AND ADULTS WITH ML IN OUR STATE. THE PROPOSED PROJECT WILL CONTRIBUTETOWARD ADVANCING HEALTH EQUITY FOR PEOPLE WITH DISABILITIES IN GEORGIA AND THROUGHOUT THE NATION.

ASSESSMENT OF APPROACH-AVOIDANCE MOTIVATION IN NEUROPSYCHIATRIC DISORDERS - ABSTRACT PAR-18-30 “DEVELOPMENT AND OPTIMIZATION OF TASKS AND MEASURES FOR FUNCTIONAL DOMAINS OF BEHAVIOR” ENCOURAGES RESEARCH PROJECTS THAT WILL DEVELOP AND OPTIMIZE NEW OR EXISTING TASKS AND MEASURES FOR THE RESEARCH DOMAIN CRITERIA (RDOC). THIS CALL STEMS FROM WORKGROUPS OF THE NATIONAL ADVISORY MENTAL HEALTH COUNCIL THAT IDENTIFIED SIGNIFICANT GAPS IN THE RDOC MEASUREMENT TOOLKIT. IN THE NEGATIVE VALENCE SYSTEMS (NVS) DOMAIN, ONE PRIORITY AREA IS THE NEED FOR BEHAVIORAL PARADIGMS FOR IDENTIFYING AREAS OF OVERLAP AND DISTINCTION BETWEEN NVS, WHICH MOTIVATE DEFENSIVE AVOIDANCE BEHAVIORS, AND POSITIVE VALENCE SYSTEMS (PVS), WHICH MOTIVATE REWARD-APPROACH BEHAVIORS. WE CONTEND THAT APPROACH-AVOIDANCE (AP-AV) PARADIGMS OFFER A PROMISING SOLUTION. AP-AV TASKS ARE ESSENTIALLY BEHAVIORAL APPROACH TESTS THAT ENABLE ASSESSMENT OF OVERT BEHAVIORAL RESPONSES TO ACUTE THREATS. THE AIMS OF THIS PROPOSAL ARE TO DEMONSTRATE THE (1) PSYCHOMETRIC ADEQUACY (TEST-RETEST RELIABILITY) AND (2) DIAGNOSTIC/PREDICTIVE VALIDITY OF A USER-FRIENDLY INSTRUCTED AP-AV-TASK WE’VE DEVELOPED FOR ASSESSING PSYCHOSOCIAL DYSFUNCTION ASSOCIATED WITH ANXIETY, DEPRESSION, PSYCHOSIS, AND OTHER CONDITIONS. OUR AIMS BUILD UPON EXTENSIVE PRELIMINARY RESEARCH IN OUR LAB DEVOTED TO OPTIMIZING TASK PARAMETERS, MEASURES AND ADMINISTRATION. THIS WORK HAS THE POTENTIAL TO YIELD AN EASY-TO-USE AND WIDELY DISSEMINABLE AP-AV TASK FOR IDENTIFYING AREAS OF OVERLAP AND DISTINCTION BETWEEN NVS AND PVS, AS WELL AS A GENERAL AP-AV METHODOLOGY THAT IS ADAPTABLE FOR ASSESSING OVERT BEHAVIORAL RESPONSES TO ACUTE THREATS. TO ACHIEVE THESE AIMS, WE WILL RECRUIT THREE MATCHED GROUPS OF ADULTS (HEALTHY, ELEVATED SOCIAL ANXIETY, AND ELEVATED SOCIAL ANHEDONIA). INCLUSION OF GROUPS WITH ANXIETY AND ANHEDONIA ARE NECESSARY TO ASSESS DIAGNOSTIC AND PREDICTIVE VALIDITY. PARTICIPANTS WILL COMPLETE STANDARDIZED CLINICAL ASSESSMENTS AND COMPLETE THE INSTRUCTED AP-AV TASK MULTIPLE TIMES DURING TWO NEUROIMAGING SESSIONS, SEPARATED BY 10-14 DAYS. BETWEEN IMAGING SESSIONS, ECOLOGICAL MOMENTARY ASSESSMENTS (EMA) WILL CAPTURE MOOD, MOTIVATIONAL LEVEL, FREQUENCY OF REAL-LIFE APPROACH/AVOIDANCE, AND EMOTIONAL REGULATION STRATEGY USE. THIS RESEARCH IS THEORETICALLY SIGNIFICANT BECAUSE IT HIGHLIGHTS THE RELEVANCE OF THEORIES OF AP-AV MOTIVATION FOR RESEARCH DEVOTED TO IDENTIFYING AREAS OF OVERLAP AND DISTINCTION BETWEEN NVS AND PVS. THIS RESEARCH IS METHODOLOGICALLY INNOVATIVE BECAUSE IT WILL PRODUCE A USER-FRIENDLY AP-AV TASK WITH STRONG PSYCHOMETRIC PROPERTIES FOR USE IN BEHAVIORAL (STAND-ALONE) OR NEUROIMAGING RESEARCH. OUTCOME DATA WILL ALSO PROVIDE THE NECESSARY EMPIRICAL FOUNDATION FOR FUTURE INVESTIGATIONS INTO THE SUITABILITY OF AP-AV TASKS FOR USE WITH INDIVIDUALS WHO VARY WIDELY IN AGE, ABILITY, AND/OR SEVERITY OF DISORDER.

FLEXIBLE MULTIVARIATE MODELS FOR LINKING MULTI-SCALE CONNECTOME AND GENOME DATA IN ALZHEIMER'S DISEASE AND RELATED DISORDERS

PHOTOPERIODIC CONTROL OF OBESITY

CYBERCORPS SCHOLARSHIP FOR SERVICE: CYBERSECURITY WORKFORCE PREPARATION IN THE AGE OF ARTIFICIAL INTELLIGENCE -THIS PROJECT AIMS TO ADDRESS THE GROWING NEED FOR A HIGHLY-SKILLED NATIONAL CYBERSECURITY WORKFORCE CAPABLE OF RESPONDING TO RAPIDLY EVOLVING CHALLENGES IN THE AGE OF ARTIFICIAL INTELLIGENCE (AI). WITH FUNDING FROM THE NSF CYBERCORPS(R) SCHOLARSHIP FOR SERVICE (SFS) PROGRAM, GEORGIA STATE UNIVERSITY (GSU) WILL PRODUCE GRADUATES CAPABLE OF ASSUMING A VARIETY OF CYBERSECURITY ROLES IN THE U.S. GOVERNMENT. MOREOVER, THE PROJECT WILL INCREASE THE DIVERSITY OF THE FEDERAL CYBERSECURITY WORKFORCE, LEVERAGING GSU'S POSITION AS A MINORITY-SERVING INSTITUTION (MSI). THE SFS PROJECT WILL EMPHASIZE RECRUITING AND GRADUATING HIGHLY QUALIFIED CANDIDATES FROM GROUPS THAT HAVE REMAINED UNDERREPRESENTED IN THE CYBERSECURITY FIELD, INCLUDING THOSE WITH MILITARY-AFFILIATIONS, FIRST-GENERATION COLLEGE ATTENDEES, AND LOW-INCOME STUDENTS. THIS PROJECT'S UNIQUE AND INNOVATIVE FOCUS WILL IMPACT THE NATION'S COMPETITIVENESS AND THE U.S. GOVERNMENT BY PRODUCING HIGHLY SKILLED CYBERSECURITY PROFESSIONALS WHO CAN DEVELOP AND DEPLOY TRUSTWORTHY CYBERSYSTEMS TO ADDRESS GRAND CHALLENGES FACING SOCIETY. GSU HAS ESTABLISHED A STRONG CURRICULUM IN CYBERSECURITY AND PRIVACY THAT BALANCES TECHNICAL RIGOR AND HANDS-ON EXPERIENCES, OFFERING STUDENTS THE OPPORTUNITY TO STUDY VARIOUS TOPICS IN CYBERSECURITY AND PRIVACY. THE PROJECT FOCUSES ON TRAINING AND PREPARING A WORKFORCE WITH INTEGRATED CYBERSECURITY, PRIVACY, AI, AND MACHINE LEARNING COMPETENCIES TO APPLY AI EXPERTISE TO CYBERSECURITY AND BUILD ROBUST AND TRUSTWORTHY AI SYSTEMS. STUDENTS WILL BE PREPARED WITH THE KNOWLEDGE AND PRACTICAL SKILLS TO APPLY AI EXPERTISE AND UNDERSTAND AI'S SAFETY, SECURITY, PRIVACY, RELIABILITY, FAIRNESS, AND ETHICAL IMPLICATIONS. OVER A FIVE-YEAR PERIOD THE PROJECT WILL PROVIDE SCHOLARSHIPS TO 25 STUDENTS STUDYING ISSUES AT THE INTERSECTION OF CYBERSECURITY AND AI. THE SFS STUDENTS WILL PARTICIPATE IN AN INTENSIVE ACADEMIC PROGRAM IN CYBERSECURITY, PRIVACY, AND TRUSTWORTHY AI, INCLUDING COURSEWORK AND RESEARCH IN CUTTING-EDGE AREAS TO SHARPEN THE STUDENTS' ABILITY FOR CREATIVE THINKING, MAKING THEM BETTER CYBERSECURITY PROFESSIONALS. IN ADDITION TO COMPLETING RIGOROUS, REQUIRED COURSEWORK, THE SFS SCHOLARS WILL ENGAGE IN EXPERIENTIAL LEARNING THROUGH OPPORTUNITIES FOR INDIVIDUAL AND GROUP RESEARCH PROJECTS AND OTHER EXTRACURRICULAR ACTIVITIES, WHICH WILL PROVIDED DEEPLY TECHNICAL AS WELL AS INTERDISCIPLINARY LEARNING EXPERIENCES AND LEADERSHIP DEVELOPMENT TAILORED TO EACH STUDENT'S PREPARATION AND ASPIRATION. THIS PROJECT IS SUPPORTED BY THE CYBERCORPS(R) SCHOLARSHIP FOR SERVICE (SFS) PROGRAM, WHICH FUNDS PROPOSALS ESTABLISHING OR CONTINUING SCHOLARSHIP PROGRAMS IN CYBERSECURITY AND ALIGNS WITH THE U.S. NATIONAL CYBER STRATEGY TO DEVELOP A SUPERIOR CYBERSECURITY WORKFORCE. FOLLOWING GRADUATION, SCHOLARSHIP RECIPIENTS ARE REQUIRED TO WORK IN CYBERSECURITY FOR A FEDERAL, STATE, LOCAL, OR TRIBAL GOVERNMENT ORGANIZATION FOR THE SAME DURATION AS THEIR SCHOLARSHIP SUPPORT. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

ADVANCING UNDERSTANDING OF RACISM-RELATED HEALTH DISPARITIES BEGINNING BEFORE BIRTH: A MULTISITE STUDY WITH BLACK AND LATINA PREGNANT WOMEN - DESCRIPTIVE TITLE: ADVANCING UNDERSTANDING OF RACISM-RELATED HEALTH DISPARITIES BEFORE BIRTH PROJECT SUMMARY/ABSTRACT RACIAL AND ETHNIC INJUSTICE ARE PREVALENT AND DEVASTATING CAUSES OF STRESS AND SUBSEQUENT HEALTH DISPARITIES. BLACK AND LATINA WOMEN EXPERIENCE A HIGHER BURDEN OF PREGNANCY COMPLICATIONS, MATERNAL MORTALITY, AND PRETERM BIRTH COMPARED TO WHITE WOMEN. THESE DISPARITIES IN BIRTH OUTCOMES ARE EXACERBATED BY SYSTEMS OF CARE THAT NEGLECT OR INVALIDATE THE EXPERIENCES OF PREGNANT WOMEN OF COLOR, CONTRIBUTING TO HIGH-RISK DELIVERIES, UNNECESSARY OBSTETRIC INTERVENTIONS, AND DEATH OF WOMEN AND INFANTS. YET, NO STUDIES HAVE EXAMINED WHETHER EXPERIENCES OF RACISM PRENATALLY AFFECT FETAL HEALTH AND DEVELOPMENT THROUGH A PROCESS OF “BIOLOGICAL EMBEDDING” OF RACISM MEASURED DAILY DURING PREGNANCY. THIS STUDY WILL ADDRESS THREE MAJOR GAPS IN THE LITERATURE TO DATE. FIRST, EXPERIENCES OF RACISM AND DISCRIMINATION ARE OFTEN MEASURED GLOBALLY, MISSING THE CUMULATIVE NATURE OF STRESS EXPOSURE ON FETAL PHYSIOLOGICAL DEVELOPMENT. SECOND, IT IS UNCLEAR WHETHER SPECIFIC PARTNER BEHAVIORS (E.G., VALIDATION OF RACISM-RELATED EXPERIENCES) AND/OR CULTURALLY-GROUNDED COPING STRATEGIES GROUNDED IN THE RADICAL HEALING FRAMEWORK (E.G., RACIAL/ETHNIC IDENTITY, ACTIVISM) CAN BUFFER EFFECTS OF RACISM ON MATERNAL PHYSIOLOGY, FETAL PHYSIOLOGY, AND BIRTH OUTCOMES. THIRD, GIVEN THE NOVELTY OF THIS RESEARCH PROGRAM, IT IS IMPORTANT TO INTEGRATE QUALITATIVE METHODS THAT CENTER THE EXPERIENCES OF BLACK AND LATINA WOMEN DURING THIS TRANSFORMATIVE AND VULNERABLE LIFE STAGE. THE OBJECTIVE OF THIS PROPOSAL IS TO ADVANCE UNDERSTANDING OF RACISM-RELATED HEALTH DISPARITIES IN PREGNANT WOMEN AND INFANTS BY (1) ENROLLING BLACK AND LATINA WOMEN DURING THE 2ND AND 3RD TRIMESTER OF PREGNANCY AND ASSESSING DAILY RACISM EXPERIENCES THROUGH DAILY DIARY ASSESSMENTS (14 CONSECUTIVE DAYS TRIMESTER); (2) MEASURING MATERNAL AND FETAL PSYCHOPHYSIOLOGY DURING THE THIRD TRIMESTER (E.G., HEART RATE, HEART RATE VARIABILITY); (3) ASSESSING NEWBORN NEURODEVELOPMENT WITHIN 48 HOURS OF BIRTH; AND (4) EXPLORING CULTURALLY-GROUNDED BUFFERS AND QUALITATIVE EXPERIENCES OF RACISM ON WOMEN AND INFANTS. WE WILL ENROLL 400 PREGNANT WOMEN FROM THE ATLANTA, GA AND SALT LAKE CITY, UT METRO AREAS (N=200/SITE), USING ESTABLISHED PROTOCOLS FOR RECRUITING AND RETAINING WOMEN DURING THIS DEVELOPMENTAL STAGE. PARTICIPATING WOMEN WILL COMPLETE QUESTIONNAIRES AND A 2-WEEK DAILY DIARY OF STRESSORS RELATED TO RACISM IN THE 2ND AND 3RD TRIMESTER. IN THE 3RD TRIMESTER, WOMEN WILL COMPLETE THESE MEASURES, A QUALITATIVE INTERVIEW, AND TWO WEEKS OF IN-HOME MATERNAL AND FETAL PHYSIOLOGICAL MEASURES, WHICH INCLUDES AN INNOVATIVE MEASURE OF FETAL HEART RATE (HR) AND HR VARIABILITY (HRV). WOMEN WILL ALSO COMPLETE A STRUCTURED INTERACTION TASK WITH THEIR ROMANTIC PARTNER OR CLOSEST SUPPORT PERSON; INVOLVING DISCUSSIONS OF HOW EACH COPE WITH RACISM-RELATED STRESSORS. WITHIN 48 HOURS OF BIRTH, INFANTS WILL COMPLETE THE NICU NETWORK NEUROBEHAVIORAL SCALE (NNNS) TO ASSESS HOW PRENATAL EXPOSURE TO RACISM MAY AFFECT NEWBORN BIRTH OUTCOMES. THIS SHORT-TERM LONGITUDINAL STUDY LAYS THE FOUNDATION FOR FURTHER FOLLOW-UP OF INFANTS AND WOMEN INTO EARLY CHILDHOOD AND A PROGRAMMATIC LINE OF RESEARCH DEVOTED TO UNDERSTANDING AND INTERVENING WITH MARGINALIZED MOTHERS AND CHILDREN TO REDUCE THE EFFECTS OF RACISM ON FAMILY HEALTH AND WELLBEING.

DEVELOPING INHIBITORS OF SEASONAL AND PANDEMIC INFLUENZA VIRUSES - SUMMARY INFLUENZA VIRUSES ARE A LEADING CAUSE OF HUMAN DISEASE DUE TO RESPIRATORY VIRAL INFECTION WORLDWIDE. IT IS THE OVERARCHING OBJECTIVE OF THIS PROJECT TO ADVANCE PRODRUG CONJUGATES OF 4’-FLUOROURIDINE (4’-FLU), A NOVEL PYRIMIDINE ANALOG WITH CONFIRMED BROAD ORAL EFFICACY AGAINST INFLUENZA VIRUSES, AND AT LEAST ONE NON-NUCLEOSIDE INHIBITOR OF THE INFLUENZA VIRUS POLYMERASE COMPLEX, TO THE STAGE OF FORMAL PRECLINICAL DEVELOPMENT AND ASSEMBLY OF AN INVESTIGATIONAL NEW DRUG-ENABLING PACKAGE. THE PROJECT DESIGN IS DRIVEN BY OUR UNDERLYING HYPOTHESIS THAT EFFECTIVE NEXT-GENERATION THERAPEUTICS FOR THE TREATMENT OF INFLUENZA MUST BE ORALLY AVAILABLE, DISPLAY A BROAD INDICATION SPECTRUM AGAINST INFLUENZA VIRUS ISOLATES OF HUMAN, AVIAN, AND SWINE LINEAGES, AND IDEALLY COVER BOTH INFLUENZA A (IAV) AND B (IBV) VIRUSES. THESE PRODUCT PROFILE DEMANDS ARE DERIVED FROM THE CLINICAL BURDEN IMPOSED BY THE DIVERSE SPECTRUM OF SEASONAL INFLUENZA VIRUSES, THE PANDEMIC POTENTIAL ARISING FROM SPILLOVER OF ZOONOTIC AVIAN VIRUSES INTO THE HUMAN POPULATION, AND CURRENT FDA RECOMMENDATIONS THAT RECOGNIZE OUTPATIENT ADULTS SUFFERING FROM SEASONAL INFLUENZA AS THE PRIMARY PATIENT POPULATION FOR INITIAL CLINICAL TESTING. THESE DEVELOPMENTAL OBJECTIVES ARE BEST MET WITH DIRECT ACTING THERAPEUTICS, SINCE HOST-TARGETED ANTIVIRAL THERAPIES, ALTHOUGH OFTEN TANTALIZINGLY BROAD IN INDICATION RANGE, ARE PRONE TO UNACCEPTABLE SIDE EFFECTS THAT ARE INCOMPATIBLE WITH THE PRIMARY PATIENT GROUP PURSUED. IN PREVIOUS WORK UNDERPINNING THIS PROGRAM, WE HAVE DEMONSTRATED BROAD-SPECTRUM ANTIVIRAL ACTIVITY OF 4’-FLU IN CULTURED CELLS AND ANIMAL INFECTION MODELS AGAINST A CLINICALLY SIGNIFICANT PANEL OF RNA VIRUSES. AGAINST THE INFLUENZA VIRUS INDICATION, 4’-FLU HAS CONFIRMED ORAL EFFICACY AGAINST SEASONAL, PANDEMIC, AND HIGHLY PATHOGENIC AVIAN INFLUENZA VIRUSES IN RODENT AND NON-RODENT MODELS. THE COMPOUND TRIGGERS IMMEDIATE CHAIN TERMINATION OF THE INFLUENZA VIRUS RNA-DEPENDENT RNA POLYMERASE (RDRP) COMPLEX AND CARRIES A HIGH BARRIER TO VIRAL RESISTANCE. IN PREPARATION OF CLINICAL DEVELOPMENT, WE HAVE GENERATED PRODRUG CONJUGATES OF 4’-FLU TO OPTIMIZE DELIVERY ACROSS THE GASTROINTESTINAL EPITHELIUM. TO BROADEN OUR INFLUENZA VIRUS RDRP INHIBITOR PORTFOLIO, WE HAVE IDENTIFIED A SET OF NON-NUCLEOSIDE RDRP INHIBITORS IN A LARGE-SCALE HIGH-THROUGHPUT SCREENING CAMPAIGN THAT WILL BE ADVANCED SIMULTANEOUSLY AS COMPANION DRUGS OR FOR COMBINATION THERAPY IN A MULTI- PRONGED APPROACH. TO SELECT A CLINICAL CANDIDATE FOR FORMAL DEVELOPMENT, 4’-FLU PRODRUG CONJUGATES WILL BE SUBJECTED TO DE-RISKING EFFICACY AND TOLERABILITY TESTING IN RELEVANT RODENT AND NON-RODENT ANIMAL MODELS AND DOSING PARADIGMS EXPLORED THROUGH INTERFACING OF DYNAMIC PK PROFILES WITH PERFORMANCE IN HUMAN AIRWAY EPITHELIUM ORGANOIDS (AIM 1). NON-NUCLEOSIDE RDRP INHIBITOR LEAD CANDIDATE SCAFFOLDS WILL BE SYNTHETICALLY DEVELOPED, MECHANISTICALLY CHARACTERIZED, AND SUBJECTED TO PROOF-OF-CONCEPT EFFICACY TESTING (AIM 2). EMERGING NON-NUCLEOSIDE LEADS WILL BE QUERIED FOR COMBINATION THERAPY WITH THE 4’-FLU CLINICAL CANDIDATE AND THE EFFECT OF MONO- AND COMBINATION THERAPY ON SUPPRESSING INFLUENZA VIRUS TRANSMISSION DETERMINED IN FERRETS (AIM 3).

1) TO SUPPORT FOR A PROGRAM AS DESCRIBED IN "DUAL MASTER'S PROGRAM IN APPLIED ECONOMMICS FOR INDONESIANS";2) TO OBLIGATE FUNDS $805 267;3) TO PR

PERSONALIZED INTEGRATED ALCOHOL AND SEXUAL ASSAULT PREVENTION AMONG COLLEGE STUDENTS - PROJECT ABSTRACT THE OVERARCHING GOAL OF THIS R01 IS TO TEST THE EFFICACY OF A BEHAVIORAL INTERVENTION FOR HEAVY EPISODIC DRINKING (HED) AND SEXUAL ASSAULT AMONG COLLEGE STUDENTS. SEXUAL AND GENDER MINORITY (SGM) STUDENTS EXPERIENCE SEXUAL ASSAULT AND ENGAGE IN HED AT EVEN HIGHER RATES THAN THEIR CISGENDER, HETEROSEXUAL PEERS. THEREFORE, TAILORED AND PERSONALIZED INTERVENTIONS ARE NEEDED FOR HED AND SEXUAL ASSAULT TO ADDRESS THE UNIQUE NEEDS OF COLLEGE STUDENTS BASED ON GENDER IDENTITY AND SEXUAL ORIENTATION. THE ALCOHOL AND SEXUAL ASSAULT PREVENTION (ASAP) PROGRAM WAS DEVELOPED BY THE RESEARCH TEAM WITH AN NIAAA-FUNDED PLANNING GRANT (R34) AND IS THE ONLY INTERVENTION THAT TARGETS BOTH HED AND SEXUAL ASSAULT (VICTIMIZATION RISK REDUCTION, PERPETRATION PREVENTION, AND BYSTANDER INTERVENTION TRAINING) IN AN INTEGRATED MANNER. ASAP PROVIDES TAILORED CONTENT ON ALCOHOL USE AND SEXUAL ASSAULT BASED ON GENDER IDENTITY AND SEXUAL ORIENTATION USING A SOCIAL NORMS AND PERSONALIZED FEEDBACK APPROACH. USABILITY TESTING AND FINDINGS FROM A RANDOMIZED CONTROLLED PILOT FEASIBILITY TRIAL SUGGEST USABILITY, FEASIBILITY, AND PRELIMINARY EFFICACY AND WARRANT RIGOROUS RANDOMIZED CONTROLLED TRIAL TESTING. ASAP IS DELIVERED IN A BRIEF, WEB-BASED FORMAT, AND ALTHOUGH SHORT-TERM OUTCOMES ARE PROMISING, MORE EFFORT IS NEEDED TO ENSURE LONG-TERM EFFICACY. THEREFORE, THE CURRENT STUDY INCLUDES AN ASSESSMENT OF ASAP AS WELL AS AN INNOVATIVE ASSESSMENT OF A 6-MONTH BOOSTER (ASAP+BOOSTER) SESSION TO DETERMINE THE MOST EFFECTIVE WAY TO DISSEMINATE ASAP TO COLLEGES NATIONWIDE IF FOUND TO BE EFFECTIVE. THE CURRENT STUDY INCLUDES THE FOLLOWING AIMS: 1A) TO TEST THE EFFICACY OF ASAP AND ASAP+BOOSTER AMONG COLLEGE STUDENTS IN REDUCING HED AND SEXUAL ASSAULT BOTH SHORT- AND LONG-TERM AMONG THREE RISK GROUPS (1. CISGENDER HETEROSEXUAL MEN; 2. CISGENDER HETEROSEXUAL WOMEN; 3. SGM); 1B) TEST THE RELATIVE EFFICACY OF A BOOSTER SESSION ON LONG-TERM ALCOHOL USE AND SA OUTCOMES; AND 2) INVESTIGATE THE MECHANISMS THROUGH WHICH ASAP CONDITIONS IMPACT ALCOHOL USE AND SA. OUTCOMES WILL BE ASSESSED AT 3-, 6-, 9-, AND 12-MONTHS POST- INTERVENTION. BY ACCOMPLISHING THESE AIMS, WE WILL ASSESS THE EFFICACY OF ASAP, A PROMISING INTERVENTION DEVELOPED BY THE RESEARCH TEAM. ASAP HAS THE POTENTIAL TO REDUCE ALCOHOL USE AMONG YOUNG ADULTS AS WELL AS REDUCE COLLEGE SA AND INCLUDES A FOCUS ON SGM POPULATIONS, ADDRESSING NIAAA AND PUBLIC HEALTH PRIORITIES.

SEX DIFFERENCES IN THE SOCIAL BRAIN

LIBERATE

PROMOTING PROSOCIAL BYSTANDER BEHAVIOR IN INTOXICATED MEN: EVALUATION OF REALCONSENT2.0

NEUROBIOLOGY OF SOCIAL BEHAVIOR

PAWS: EFFICACY

HEALTHY START INITIATIVE - PROJECT TITLE: GEORGIA STRONG FAMILIES PROGRAM (GSFP) ADDRESS: 55 PARK PLACE ATLANTA, GEORGIA 30303 PROJECT DIRECTOR NAME: TWANNA NELSON CONTACT PHONE NUMBER: 4044130301 EMAIL ADDRESS: TNELSON45@GSU.EDU WEBSITE ADDRESS: HTTPS://GHPC.GSU.EDU/ GRANT FUNDS REQUESTED: $1,100,000 ANNUALLY POPULATION SERVED: THE GSFP TARGET POPULATION IS BLACK WOMEN OF CHILDBEARING AGE (14-51) RESIDING IN THE PROJECT AREA. THIS POPULATION HAS BEEN DETERMINED TO HAVE THE HIGHEST INFANT AND MATERNAL MORTALITY RATES THEREBY NEEDING THE SUPPORT OF HEALTHY START. CHALLENGE (NEEDS ADDRESSED) THE HEALTHY START FUNDING WILL PROVIDE GEORGIA WITH AN OPPORTUNITY TO FURTHER STRENGTHEN THE SYSTEM OF CARE FOR FAMILIES AND EXPAND SERVICES. GEORGIA CONTINUES TO NEED LAYERED EARLY INTERVENTION AND PREVENTION SERVICES TO ADDRESS ADVERSE HEALTH OUTCOMES. GEORGIA IS SEEN AT THE TOP OF MANY LISTS, INCLUDING FORBES’ 2023 WORST STATES FOR HEALTHCARE LIST, WHICH COMPILES TWENTY-FOUR METRICS SPANNING FOUR KEY CATEGORIES: HEALTH ACCESS, HEALTHCARE OUTCOMES, HEALTHCARE COST, AND QUALITY OF HOSPITAL CARE. MORE SPECIFICALLY THE 3-YEAR IMR (2019-2021) FOR THE TARGET POPULATION IN THE EIGHT COUNTIES IS 12.5 (COMPARED TO 5.9 FOR WHITE WOMEN IN THE SAME REGION), THE 3-YEAR PRETERM BIRTH RATE IS 17.8 (COMPARED TO 12.2 FOR WHITE WOMEN), AND THE 3-YEAR LOW BIRTHWEIGHT RATE IS 17.8 (COMPARED TO 12.2 FOR WHITE WOMEN). THIS EIGHT-COUNTY REGION IS SERVED BY TWO HOSPITALS WITH OBSTETRIC CARE, TWO RURAL HEALTH CLINICS, AND HAS AN OB-GYN PROVIDER RATE OF 7.7, WITH HALF OF THE COUNTIES NOT HAVING ANY OB-GYN PROVIDERS WITHIN THE COUNTY. METHODOLOGY (PROPOSED SERVICES): THE GOAL OF THE GSFP IS TO IMPROVE CHILD AND FAMILY OUTCOMES BY IMPLEMENTING STRATEGIES WITHIN A COMMUNITY-BASED PUBLIC HEALTH MATERNAL AND EARLY CHILDHOOD SYSTEM. GSFP IS DESIGNED TO 1) IMPROVE COORDINATION OF SERVICES FOR CHILDREN AND FAMILIES AT THE STATE AND LOCAL LEVELS; AND 2) PROVIDE COMPREHENSIVE SERVICES TO IMPROVE OUTCOMES FOR CHILDREN AND FAMILIES WHO RESIDE IN CRISP, CLAY, DOOLY, MUSCOGEE, STEWART, SUMTER, TALBOT, AND TAYLOR COUNTIES. THE PROJECT AREA IS COMPRISED OF MOSTLY RURAL COUNTIES. FUNDING SUPPORTS THE IMPLEMENTATION OF GSFP WHICH TARGETS THE NEEDS OF EXPECTANT PARENTS, CHILDREN AGED FROM BIRTH TO 18 MONTHS, AND THEIR FAMILIES. THE SYSTEM FUNCTIONS INCLUDE IDENTIFICATION, REFERRAL, SCREENING, PARENT EDUCATION, AND LINKAGE TO APPROPRIATE COMMUNITY SERVICES. THIS REQUIRES STRONG COLLABORATIONS BETWEEN COMMUNITY AGENCIES SERVING CHILDREN AND FAMILIES, WHICH THE GSFP HAS HISTORICALLY BEEN SUCCESSFUL THROUGH ITS ESTABLISHED COMMUNITY CONSORTIUM. ONE MAJOR SERVICE STRATEGY FOR THIS SYSTEM IS THE USE OF THE PARTNERS FOR HEALTHY BABIES HOME-VISITING MODEL. THE GSFP WILL PROVIDE BOTH VIRTUAL AND IN-PERSON VISITS TO ENSURE FAMILIES ARE SUPPORTED BEFORE, DURING, AND AFTER PREGNANCY. THE GSFP WILL ALSO PROVIDE ENHANCED SERVICES TO THE TARGET POPULATION THROUGH A NURSE PRACTITIONER (NP) AND PROVISIONS FOR DOULAS SERVICES. THE NP WILL PROVIDE HOME VISITS, AND EDUCATION TO FAMILIES AND STAFF ON WARNING SIGNS ALONG WITH AN EMPHASIS ON ENCOURAGING POSTPARTUM FOLLOW-UP AND CARE. MOTHERS ENROLLED WILL HAVE ACCESS TO DOULA SERVICES DURING PREGNANCY, FOR SUPPORT DURING CHILDBIRTH AND UP TO 3 MONTHS POSTPARTUM. GSFP WILL BE INTENTIONAL ABOUT INCORPORATING MENTAL/BEHAVIORAL HEALTH AS A KEY STRATEGY TO IMPROVING BOTH PHYSICAL AND MENTAL WELL-BEING. THE GSFP WILL ADDRESS MENTAL AND BEHAVIORAL HEALTH CHALLENGES IN THE FATHER, MOTHER, AND INFANTS TO ENSURE A HIGHER QUALITY OF LIFE. IMPLEMENTATION ALSO INCLUDES THE DEVELOPMENT OF A COHESIVE PLAN TO PROMOTE PROGRAM QUALITY AND EFFECTIVENESS, AS WELL AS A COORDINATED DATA SYSTEM TO GUIDE DECISION-MAKING AND ASSIST COUNTIES IN MONITORING PROGRESS TOWARD DESIRED RESULTS AND CONTINUOUS QUALITY IMPROVEMENT.

ESTABLISHING SMOKE-FREE HOMES WITH FAMILIES INVOLVED IN CHILD PROTECTIVE SERVICES: AN EFFECTIVENESS-IMPLEMENTATION TRIAL OF AN INTEGRATED PROGRAM - PROJECT ABSTRACT CHILD EXPOSURE TO SECONDHAND SMOKE (SHS) IS LINKED TO MULTIPLE FORMS OF CANCER THROUGHOUT THE LIFESPAN. YOUNG CHILDREN LIVING IN LOW-SOCIOECONOMIC STATUS HOUSEHOLDS ARE AT INCREASED RISK FOR SHS EXPOSURE. FAMILIES INVOLVED WITH THE CHILD PROTECTION SYSTEM AS THE RESULT OF SUBSTANTIATED CHILD MALTREATMENT ARE AN ESPECIALLY HIGH-RISK GROUP FOR SHS, AS THESE FAMILIES ARE OFTEN LIVING IN POVERTY AND REPORT HIGH DAILY SMOKING RATES. IMPORTANTLY, CHILD MALTREATMENT VICTIMIZATION ALSO INCREASES RISK OF CANCER AND PREMATURE DEATH FROM CANCER, INDEPENDENT OF PARENT SMOKING BEHAVIOR. IDENTIFYING WAYS TO BROADLY DISSEMINATE EFFECTIVE SHS PREVENTION PROGRAMS TO THESE HIGH-RISK FAMILIES IS AN IMPORTANT STRATEGY FOR REDUCING CANCER DISPARITIES. WE PROPOSE AN EFFECTIVENESS-IMPLEMENTATION HYBRID TRIAL TYPE 1 TO EXAMINE THE IMPACT OF INTEGRATING TWO EVIDENCE-BASED PROGRAMS, SOME THINGS ARE BETTER OUTSIDE (SHS PREVENTION PROGRAM) AND SAFECARE® (CHILD MALTREATMENT PREVENTION PROGRAM), ON ESTABLISHING A SMOKE-FREE HOME AND ON IMPLEMENTATION PROCESS OUTCOMES. AIM 1 FOCUSES ON THE REFINEMENT OF THE STANDARDIZED INTEGRATION (SYSTEMATIC BRAIDING) OF THE TWO PROGRAMS INTO “SMOKE-FREE SAFECARE (SFSC).” AIMS 2 AND 3 FOCUS ON THE HYBRID TRIAL. FIFTY CERTIFIED SAFECARE PROVIDERS WILL BE RECRUITED AND RANDOMLY ASSIGNED TO DELIVER EITHER SFSC OR STANDARD SAFECARE. PROVIDERS WILL EACH SERVE TEN RESEARCH FAMILIES (N = 500) WHO MEET THE INCLUSION CRITERIA (MOTHER OR ANOTHER PERSON RESIDING IN THE HOME SMOKES AT HOME). THE PRIMARY OUTCOME, SMOKE-FREE HOME STATUS, WILL BE MEASURED VIA SELF-REPORT AT 4-TIMEPOINTS (BASELINE, 8-WEEKS, 20-WEEKS, AND 1-YEAR), AND VALIDATED VIA AIR NICOTINE MONITOR AT 8 WEEKS AND 1-YEAR (AIM 2). PROCESS MEASURES WILL BE COLLECTED TO EXAMINE HOW THE BRAIDED INTERVENTION IMPACTS PROVIDER FIDELITY, DELIVERY TIME AND COSTS, AND OTHER PROCESS MEASURES (AIM 3). IF EFFECTIVE, SFSC CAN BE EFFICIENTLY DISSEMINATED FOR WIDESPREAD ADOPTION BY THE NATIONAL SAFECARE TRAINING AND RESEARCH CENTER TO THE OVER 100 ACCREDITED SAFECARE AGENCIES ACROSS THE UNITED STATES AND WORLDWIDE THAT SERVE PARENTS INVOLVED WITH CHILD PROTECTION SERVICES, REDUCING CANCER RISK AND DISPARITIES FOR A HIGH-RISK POPULATION.

ORTHOGONAL UBIQUITIN TRANSFER TO PROFILE E3 SUBSTRATE SPECIFICITY

SEX DIFFERENCES IN STRESS INOCULATION OF ADDICTION-LIKE PHENOTYPES

ASSESSING THE EFFECTIVENESS OF THE SECOND CHANCE ACT GRANT PROGRAM THROUGH A PHASED EVALUATION APPROACH USING AN IMPLEMENTATION SCIENCE MIXED METHODS APPROACH

DATA-DRIVEN SOLUTIONS FOR TEMPORAL, SPATIAL, AND SPATIOTEMPORAL DYNAMIC FUNCTIONAL CONNECTIVITY - PROJECT SUMMARY/ABSTRACT EXISTING APPROACHES TO ESTIMATE AND CHARACTERIZE WHOLE BRAIN TIME-VARYING CONNECTIVITY FROM FMRI DATA HAVE SHOWN CONSIDERABLE PROMISE, WITH EXPONENTIAL GROWTH IN RESEARCH IN THIS FIELD. WE AND OTHERS HAVE DEVELOPED A POWERFUL SET OF TOOLS THAT ARE NOW IN WIDE USE IN THE COMMUNITY. HOWEVER, THE IMPACT OF MENTAL ILLNESS ON BRAIN CONNECTIVITY IS COMPLEX, AND AS WE SHOW, LIMITATIONS IN EXISTING METHODS OFTEN RESULT IN MISSING IMPORTANT FEATURES ASSOCIATED WITH BRAIN DISORDERS (E.G. TRANSIENT FRACTIONATION OF THE SPATIAL STRUCTURE OF BRAIN NETWORKS). SOME OF THESE IMPORTANT LIMITATIONS INCLUDE 1) THE MOST WIDELY-USED APPROACHES OFTEN REQUIRE A NUMBER OF PRIOR AND LIMITING ASSUMPTIONS THAT ARE NOT WELL STUDIED, 2) METHODS OFTEN ASSUME LINEAR RELATIONSHIPS EITHER WITHIN OR BETWEEN NETWORKS OVER TIME, AND 3) METHODS ASSUME SPATIALLY FIXED NODES AND IGNORE THE POSSIBILITY OF SPATIALLY FLUID EVOLUTION OF NETWORKS OVER TIME. WE PROPOSE A NOVEL FAMILY OF MODELS THAT BUILDS ON THE WELL-STRUCTURED FRAMEWORK OF JOINT BLIND SOURCE SEPARATION TO CAPTURE A MORE COMPLETE CHARACTERIZATION OF (POTENTIALLY NONLINEAR) SPATIO-TEMPORAL DYNAMICS WHILE PROVIDING A WAY TO RELAX OTHER LIMITING ASSUMPTIONS. OUR MODELS WILL ALSO PRODUCE A RICH SET OF METRICS TO CHARACTERIZE THE AVAILABLE DYNAMICS AND ENABLE IN DEPTH COMPARISON WITH CURRENTLY AVAIL- ABLE MODELS INCLUDING THOSE THAT ARE MODEL BASED. WE WILL EXTENSIVELY VALIDATE OUR APPROACHES IN A VARIETY OF WAYS INCLUDING SIMULATIONS AND EVALUATION OF RIGOR AND ROBUSTNESS IN LARGE NORMATIVE DATA SETS. FINALLY, WE WILL APPLY THE DEVELOPED TOOLS TO STUDY THE IMPORTANT AREA OF DYNAMIC PROPERTIES IN MENTAL ILLNESSES INCLUDING SCHIZ- OPHRENIA, BIPOLAR DISORDER, AND THE AUTISM SPECTRUM. THERE IS CONSIDERABLE EVIDENCE OF DISRUPTION OF DYNAMICS IN ALL THREE DISORDERS, AND AS WE SHOW THE USE OF STATIC (OR EVEN EXITING DYNAMIC) APPROACHES CAN MISS IMPORTANT INFORMATION ABOUT BRAIN RELATED DIFFERENCES ASSOCIATED WITH EACH. WE WILL PROVIDE OPEN SOURCE TOOLS AND RELEASE DATA THROUGHOUT THE DURATION OF THE PROJECT VIA A WEB PORTAL AND THE NITRC REPOSITORY, HENCE ENABLING OTHER INVESTIGATORS TO USE OUR APPROACHES AND COMPARE THEIR OWN METHODS WITH OUR OWN. OUR TOOLS HAVE WIDE APPLI- CATION TO THE STUDY OF THE HEALTHY BRAIN AS WELL AS MANY OTHER DISEASES SUCH AS ALZHEIMER'S DISEASE AND ATTENTION DEFICIT HYPERACTIVITY DISORDER. 38

CRCNS: CYTOSKELETAL MECHANISMS OF DENDRITE ARBOR SHAPE DEVELOPMENT

MINDFULNESS-BASED SMOKING CESSATION ENHANCED WITH MOBILE TECHNOLOGY FOR LOW-INCOME SMOKERS

COMBINATIONAL REGULATION OF INFLAMMATION IN OTITIS MEDIA

RATIONAL DESIGN OF TRANSFERRIN BINDING PROTEIN-BASED VACCINES TO COMBAT GONORRHEA

SMOKERS' DECISION-MAKING ABOUT TOBACCO USE: THE INTERPLAY OF AFFECTIVE AND COGNITIVE FACTORS WITH PRODUCT CHARACTERISTICS

THE DEVELOPMENT OF JOINT ATTENTION AFTER INFANCY

ALTERED CNS INTERCELLULAR SIGNALING MECHANISMS IN CARDIOVASCULAR DISEASE

RFA-DP-24-004, PRC CORE: PROMOTING SOCIAL CONNECTEDNESS IN THE MOST DIVERSE SQUARE MILE IN AMERICA

DEVELOPING STEM PROFESSIONALS AS EDUCATORS AND TEACHER LEADERS

THE NATIONAL CENTER ON CHILD TRAFFICKING: INNOVATION AND DISSEMINATION OF EVIDENCE-BASED TRAUMA TREATMENT AND SERVICES FOR CHILDREN AND FAMILIES IMPACTED BY TRAFFICKING - .“THE NATIONAL CENTER ON CHILD TRAFFICKING: INNOVATION AND DISSEMINATION OF EVIDENCE-BASED TRAUMA TREATMENT AND SERVICES FOR CHILDREN AND FAMILIES IMPACTED BY TRAFFICKING” WILL ESTABLISH A NATIONAL NETWORK OF EXPERTS IN TRAUMA, TRAFFICKING, AND IMPLEMENTATION SCIENCE TO DEVELOP, ADAPT, DELIVER, AND DISSEMINATE PRODUCTS, RESOURCES, AND INTERVENTIONS TO IMPROVE OUTCOMES FOR YOUTH AND FAMILIES WHO HAVE EXPERIENCED COMMERCIAL SEXUAL EXPLOITATION AND TRAFFICKING (CSET). YOUTH WHO HAVE EXPERIENCED CSET HAVE VERY HIGH RATES OF TRAUMA EXPOSURE, INCLUDING EARLY TRAUMA (E.G. SEXUAL ABUSE, TRAUMATIC LOSS/ SEPARATION, FAMILY VIOLENCE) AS WELL AS TRAUMA WHILE BEING TRAFFICKED (E.G. PHYSICAL/SEXUAL VIOLENCE BY TRAFFICKERS/ PURCHASERS). THE CUMULATIVE IMPACT OF THESE TRAUMATIC EXPERIENCES LEADS TO HIGH RATES OF POST-TRAUMATIC STRESS, DEPRESSION, ANXIETY, SUBSTANCE USE, AND SELF-INJURY. CSET OCCURS TO YOUTH OF ALL AGES, GENDERS, AND RACES/ETHNICITIES; HOWEVER, YOUTH OF COLOR AND LGBTQ YOUTH ARE SIGNIFICANTLY OVER-REPRESENTED AND MALES ARE UNDERIDENTIFIED. THE NATIONAL CENTER ON CHILD TRAFFICKING (NCCT) WILL INCREASE AND IMPROVE ACCESS TO TRAUMA-FOCUSED EVIDENCE-BASED MENTAL TREATMENTS AND TRAUMA-INFORMED INTERVENTIONS GUIDED BY PRINCIPLES OF TRAUMA-INFORMED CARE TAILORED AND ADAPTED TO MEET THE NEEDS OF YOUTH WHO HAVE EXPERIENCED CSET, AS WELL AS INCREASE AND IMPROVE TRAUMA AND TRAFFICKING AWARENESS AND COLLABORATIVE MULTI-DISCIPLINARY CROSS-SECTOR RESPONSE. THE NCCT WILL (1) DEVELOP AND DISSEMINATE NATIONAL PRACTICE STANDARDS AND CONSENSUS GUIDELINES FOR MH TREATMENT CROSSCUTTING EBPS TO 1000 MENTAL HEALTH PROFESSIONALS AND WEBINAR TRAINING TO 4000 PROFESSIONALS, (2) DELIVER AND EVALUATE TRAINING OF TF-CBT FOR CSET TO 250 THERAPISTS IN 5 SAMHSA/HHS REGIONS, DEVELOP RESOURCES FOR THERAPISTS AND TRAINERS TO ENHANCE DISSEMINATION AND SERVICE DELIVERY, DISSEMINATE TO 1000 PROVIDERS, (3) DEVELOP AND DISSEMINATE STANDARDS, GUIDELINES, AND TRAINING ADDRESSING CO-OCCURRING TRAUMA AND SUBSTANCE USE PROBLEMS TO 1000 MENTAL HEALTH AND SUBSTANCE ABUSE PROFESSIONALS, WEBINAR TRAINING TO 1600 PROFESSIONALS, INTEGRATE THE GUIDELINES INTO AN EXISTING EVIDENCE-BASED TRAUMA AND SUBSTANCE USE TREATMENT, RISK REDUCTION THROUGH FAMILY THERAPY, AND TRAIN 50 THERAPISTS IN THE ADAPTED MODEL, (4) ADAPT AND DISSEMINATE TRAINING IN TRAUMA-INFORMED PARENTING, THE RESOURCE PARENT CURRICULUM, ADAPTED FOR YOUTH WHO HAVE EXPERIENCED CSET TO 100 RPC FACILITATORS, (5) ADAPT AND DISSEMINATE TRAINING IN TRAUMA-INFORMED RESIDENTIAL CARE, THINK TRAUMA. TO 50 THINK TRAUMA TRAINERS, AND TRAIN STAFF AT TARGETED CSET CONGREGATE CARE/RESIDENTIAL TREATMENT PLACEMENTS, (6) DEVELOP AND DISSEMINATE RESOURCES FOR MDT AND CSET SPECIALIST PROFESSIONALS, INCLUDING PRACTICE GUIDELINES AND TRAINING CURRICULA (FORECAST) INCORPORATING CSET RESPONSE TO 650 PROFESSIONALS, WEBINAR TRAINING TO 400 PROFESSIONALS, (7) DEVELOP SECONDARY TRAUMATIC STRESS/COMPASSION FATIGUE AWARENESS MATERIALS AND STRATEGIES AND DELIVER TRAINING IN THE PRACTICES TO 1000 PROFESSIONALS SERVING YOUTH WHO HAVE EXPERIENCED CSET. OVER 11,000 PEOPLE WILL BE IMPACTED BY THE PROJECT THROUGH RESOURCES DEVELOPED AND DISSEMINATED AND TRAININGS PROVIDED (1490 Y2, 2565 Y3, 2630 Y4, 5250 Y5).

COMPARATIVE IMMUNOLOGY OF FILOVIRUS RESERVOIR ROUSETTUS AEGYPTIACUS

NOVEL NONLINEAR OPTICAL PROCESSES IN ACTIVE, RANDOM AND NANOSTRUCTURED SYSTEMS