University Of Mississippi

INSTITUTIONAL PORTION--CARES ACT HIGHER EDUCATION EMERGENCY RELIEF FUND

SCIENCE BASED AUTHENTICATION OF DIETARY SUPPLEMENTS

MISSISSIPPI CENTER FOR CLINICAL AND TRANSLATIONAL RESEARCH

CARES ACT HIGHER EDUCATION EMERGENCY RELIEF FUND

TELEHEALTH CENTER OF EXCELLENCE

MISSISSIPPI CENTER OF EXCELLENCE IN PERINATAL RESEARCH

CARDIOVASCULAR DYNAMICS AND THEIR CONTROL

CADIORENAL AND METABOLIC DISEASES RESEARCH CENTER

UNIVERSITY OF MISSISSIPPI MEDICAL CENTER BIOTECHNOLOGY RESEARCH PARK

THE UNIVERSITY OF MISSISSIPPI RESEARCH PARK

HEALTH CARE AND OTHER FACILITIES

VALUE-BASED MEDICAL STUDENT EDUCATION TRAINING PROGRAM

2009 THE INSTITUTE FOR THE IMPROVEMENT OF MINORITY HEALTH AND HEALTH DISPARITIES IN THE DELTA REGION

THE NATIONAL INSTITUTE FOR UNDERSEA SCIENCE AND TECHNOLOGY - 2007-2010 UNDERSEA RESEARCH IN BITOTECHNOLOGY AND ENVIRNMENTAL TECHNOLOGY

GLYCORE: GLYCOSCIENCE CENTER OF RESEARCH EXCELLENCE

VALUE-BASED MEDICAL STUDENT EDUCATION TRAINING PROGRAM

PHASE II CONSTRUCTION OF NCNPR RESEARCH WING

HEALTH CARE AND OTHER FACILITIES

ARIC NEUROCOGNITIVE STUDY

EARLY CHILDHOOD HEALTH PROMOTION SYSTEM FOR HIGH NEED PROGRAM

MOLECULAR CENTER OF HEALTH AND DISEASE - OVERALL-ABSTRACT CHRONIC DISEASES, SUCH AS HEART DISEASE, DIABETES, AND CANCER ARE AMONG THE MOST PREVALENT HEALTH CONDITIONS IN THE UNITED STATES, RESPONSIBLE FOR 7 OUT OF EVERY 10 DEATHS. MISSISSIPPI RANKS FIRST OR SECOND IN 8 OF 10 LEADING CAUSES OF DEATH, WITH 90% OF THE POPULATION HAVING 1-2 CHRONIC DISEASES. WHILE CHRONIC DISEASES CAN BE TREATED THROUGH EARLY INTERVENTION, TARGETED MEDICAL THERAPIES, AND IMPROVED DIET AND EXERCISE, AN UNDERSTANDING OF GENETIC SUSCEPTIBILITY AND MOLECULAR MECHANISMS INVOLVED IN DISEASE ONSET HAS THE POTENTIAL TO HALT PROGRESSION AND RETURN AN INDIVIDUAL TO A HEALTHIER STATE. ADVANCES IN TECHNOLOGY NOW ALLOW FOR UNPRECEDENTED INSIGHT INTO GENOME COMPLEXITY AND ITS INTERACTION WITH THE ENVIRONMENT USING GENOMIC, TRANSCRIPTOMIC, PROTEOMIC, AND METABOLOMIC DATASETS. THE INTEGRATION OF THESE DATASETS WITH PHYSIOLOGICAL INFORMATION USING COMPUTATIONAL APPROACHES CAN PROVIDE SYSTEMATIC INSIGHT INTO THE MOLECULAR, CELLULAR, AND OVERALL PHYSIOLOGY ASSOCIATED WITH THE HEALTH-DISEASE CONTINUUM. WE PROPOSE TO ESTABLISH A NEW PHASE I COBRE, THE MOLECULAR CENTER OF HEALTH AND DISEASE (MCHD) TO FACILITATE RESEARCH UNDER A CENTRAL THEME OF MOLECULAR PHYSIOLOGY TO ENHANCE THE DEPTH OF EDUCATION, MENTORSHIP, AND TRAINING OF RESEARCHERS TO GENERATE UNIQUE OPPORTUNITIES IN THE APPLICATION OF OMICS TECHNOLOGY AND COMPUTATIONAL BIOLOGY. THE MCHD WILL BE COMPRISED OF MULTIPLE COMPONENTS INCLUDING AN ADMINISTRATIVE UNIT, EDUCATION AND MENTORING PROGRAMS, A PILOT PROJECT PROGRAM, TWO RESEARCH CORES, AND THREE MAJOR PROJECT INVESTIGATORS. THE OVERALL OBJECTIVES OF THE MCHD ARE: (1) TO DEVELOP INFRASTRUCTURE AND STATE-OF- THE-ART RESEARCH CORE FACILITIES ESSENTIAL FOR CUTTING EDGE BASIC, CLINICAL, AND TRANSLATIONAL APPROACHES TO STUDY THE HEALTH AND DISEASE CONTINUUM. THE MCHD, THROUGH CORE B WILL ENHANCE EXISTING -OMICS TECHNOLOGY (E.G., SINGLE CELL RNASEQ AND SPATIAL TRANSCRIPTOMICS), PROTEOMIC CAPABILITIES, AND ESTABLISH A NEW INNOVATIVE CORE, INVOLVING CRISPR/CAS9 GENE-EDITING TECHNOLOGY TO INTERROGATE GENE FUNCTION AND BIOLOGICAL PATHWAYS; AND CORE C WILL ESTABLISH CRITICAL COMPUTING INFRASTRUCTURE AND COMPUTATIONAL BIOLOGY ANALYSIS NOT CURRENTLY AVAILABLE AT THE UNIVERSITY; (2) TO ESTABLISH MEANINGFUL EDUCATION, MENTORING PROGRAMS, AND RESEARCH SUPPORT FOR PROMISING NEW INVESTIGATORS TO NURTURE THEM INTO PRODUCTIVE, INDEPENDENTLY FUNDED INVESTIGATORS, WHO WILL BE EFFECTIVE COLLABORATORS ON MULTIDISCIPLINARY RESEARCH TEAMS. THIS WILL BE ACCOMPLISHED THROUGH OFFERING A “GENETIC AND - OMICS ACADEMY” (DIDACTIC INSTRUCTION AND OBSERVERSHIP) TO STRENGTHEN RESEARCHER UNDERSTANDING OF MOLECULAR AND COMPUTATIONAL APPROACHES, A ROBUST MENTORING PROGRAM INVOLVING ONE-ON-ONE AND TEAM MENTORING, CAREER DEVELOPMENT OPPORTUNITIES, AND PROVIDING A HIGH LEVEL OF RESEARCH SUPPORT THROUGH EACH CORE; AND (3) TO ENHANCE COLLABORATIONS AND INTERACTIONS AMONG INVESTIGATORS ACROSS MULTIPLE DISCIPLINES AT UMMC, PROMOTE COOPERATION BETWEEN OTHER IDEA SUPPORTED PROGRAMS, INCLUDING EXISTING COBRE, IDEA-CTR, AND EXTERNAL PARTNERSHIP WITH THE MISSISSIPPI-INBRE.

CENTER OF RESEARCH EXCELLENCE IN NATURAL PRODUCTS NEUROSCIENCE (CORE-NPN)

DISCOVERY AND DEVELOPMENT OF NATURAL PRODUCTS FOR PHARMACEUTICAL AND AGRICHEMICAL APPLICATIONS II - THE OVERALL GOAL OF THIS PROJECT IS TO DISCOVER, DEVELOP AND FOSTER COMMERCIALIZATION OF NEW BIOACTIVE PRODUCTS AS NEW PHARMACEUTICALS OR AGRICHEMICALS, AND TO IDENTIFY, CHARACTERIZE AND DEVELOP PLANTS FOR PRODUCTION OF PHARMACEUTICALS OR PESTICIDES AS POTENTIAL ALTERNATIVE CROPS.

CORBE: CENTER FOR PSYCHIATRIC NEUROSCIENCE

HEALTH CARE AND OTHER FACILITIES

HYPERTENSION AND CARDIORENAL DISEASES RESEARCH TRAINING PROGRAM

AWARE IN MISSISSIPPI (AIM) - SUMMARY: AWARE IN MISSISSIPPI (AWARE MS) IS A PARTNERSHIP BETWEEN THE MS DEPARTMENT OF EDUCATION (MDE), THE MS ACHIEVEMENT SCHOOL DISTRICT (MASD), MS DEPARTMENT OF MENTAL HEALTH (MDH), OUR STATE’S FEDERATION OF FAMILIES ORGANIZATION, COMMUNITY PROVIDERS, AND MULTIPLE PROGRAMS ACROSS THREE MS UNIVERSITIES (MSU, USM, UMMC). AWARE MS AIMS TO INCREASE MENTAL HEALTH AWARENESS, FOSTER RESILIENCE, AND STRENGTHEN ACCESS TO TRAUMA-INFORMED, CULTURALLY RESPONSIVE, AND FAMILY DRIVEN MENTAL HEALTH SERVICES AND SUPPORTS IN HUMPHREYS COUNTY AND YAZOO CITY SCHOOL DISTRICTS (THE LEAS). BOTH DISTRICTS ARE HOUSED WITHIN THE MASD, A DISTINCT SEA THAT AIMS TO TRANSFORM PERSISTENTLY FAILING MS PUBLIC SCHOOLS. LED BY THE UNIVERSITY OF MISSISSIPPI MEDICAL CENTER, AWARE MS WILL COLLABORATE TO DEVELOP AND IMPROVE A SCHOOL-BASED CONTINUUM OF AWARENESS, PREVENTION, TRAINING, AND SERVICE LINKAGE AND DELIVERY FOCUSED ON THE MASD AND PRIMED TO SCALE TO OTHER MISSISSIPPI LEAS ACROSS THE STATE. POPULATION: 3250 SCHOOL-AGED YOUTH (K-12) AND 535 SCHOOL STAFF IN HUMPHREYS AND YAZOO CITY SCHOOL DISTRICTS. BOTH MASD DISTRICTS ARE LOCATED IN THE MISSISSIPPI (MS) DELTA REGION, A RURAL AND UNDERSERVED REGION WITH SIGNIFICANT RATES OF CHILD ADVERSITY AND POVERTY. MASD DISTRICTS HAVE SIGNIFICANTLY HIGHER PROPORTIONS OF BLACK YOUTH (HUMPHREYS = 97%; YAZOO CITY = 98%) THAN STATE AVERAGES. PREVALENCE OF CHILDHOOD MENTAL HEALTH (MH) DISORDERS IN MS IS HIGHER (20%) THAN U.S. ESTIMATES, AND NEARLY 66% DO NOT RECEIVE TREATMENT—THE WORST RATE IN THE U.S. BOTH MASD DISTRICTS ARE IN HRSA-DESIGNATED MENTAL HEALTH PROFESSIONAL SHORTAGE AREAS. GOAL 1. INCREASE AWARENESS AND LITERACY AMONG TEACHERS, SCHOOL-BASED STAFF, CAREGIVERS, AND COMMUNITY ORGANIZATIONS TO IDENTIFY AND RESPOND EFFECTIVELY TO SCHOOL AGED YOUTH MH PROBLEMS AND CO-OCCURRING NEEDS. KEY OBJECTIVES: IMPLEMENT MH AWARENESS, SUICIDE PREVENTION AND POSTVENTION PROGRAMS; DISSEMINATE A TRAUMA-INFORMED TOOLKIT FOR SCHOOL STAFF AND PARENTS. EXPECTED TO REACH A 4-YEAR TOTAL OF 2200 UNIQUE INDIVIDUALS. GOAL 2. ENHANCE RESILIENCY AND MH WELL-BEING FOR ALL SCHOOL-AGED YOUTH THROUGH IMPLEMENTATION OF A SOCIAL-EMOTIONAL LEARNING (SEL) CURRICULUM INTEGRATED INTO GENERAL CURRICULUM AND LINKED TO SCHOOL-WIDE IMPLEMENTATION OF TRAUMA-INFORMED PRINCIPLES. KEY OBJECTIVES: IMPLEMENT SEL CURRICULUM AND TRAINING WITH TEACHERS TO PROMOTE SEL IN STUDENTS. OFFER TRAUMA-INFORMED TRAININGS TO YOUTH SERVING ADULTS AND PARENTS. EXPECTED TO REACH A 4-YEAR TOTAL OF 1830 UNIQUE INDIVIDUALS ACROSS STUDENTS, TEACHERS, SCHOOL STAFF, AND PARENTS. GOAL 3. IMPROVE A MULTI-TIERED SYSTEM OF SUPPORT VIA A ROBUST SUITE OF TRAINING AND WORKFORCE CAPACITY BUILDING ACTIVITIES TO SCHOOL STAFF AND PARENTS THAT PROVIDES MH PROMOTION, PREVENTION, AND INTERVENTION SERVICES ALONG A PUBLIC HEALTH CONTINUUM TO MEET STUDENTS’ NEEDS. KEY OBJECTIVES: SCHOOL-WIDE UNIVERSAL SCREENING FOR MH, ADVERSE CHILDHOOD EXPERIENCES AND SUICIDALITY; IMPLEMENT SUITE OF UNIVERSAL PREVENTION PROGRAMS; PROVIDE ON-DEMAND CONSULTATION AND DISTANCE LEARNING FOR MENTAL HEALTH THERAPISTS. EXPECTED TO REACH A 4-YEAR TOTAL OF 9100. GOAL 4. INCREASE AND IMPROVE STUDENT AND FAMILY ACCESS TO CULTURALLY RELEVANT, AND TRAUMA-INFORMED SCHOOL AND COMMUNITY-BASED ACTIVITIES AND SERVICES THROUGH A COORDINATED SYSTEM OF CARE ACROSS LEAS, COMMUNITY AGENCIES, AND LEA, SEA, AND SCHOOL-BASED POLICY DEVELOPMENT. KEY OBJECTIVES: COORDINATE COMMUNITY REFERRAL PATHWAYS, DEVELOP/IMPLEMENT (A)CRISIS RESPONSE AND (B) SCHOOL SAFETY AND THREAT/VIOLENCE PREVENTION PLAN WITH MULTIDISCIPLINARY TEAM. EXPECTED TO REACH A 4-YEAR TOTAL OF 200 INDIVIDUALS.

ARTIFICIAL INTELLIGENCE (AI) POWERED SELF-DRIVING DRUG DISCOVERY & DEVELOPMENT - THE INCREASING DEMAND FOR ADVANCED PHARMACEUTICALS NECESSITATES TRANSFORMATIVE APPROACHES TO DRUG DISCOVERY, DEVELOPMENT, AND MANUFACTURING. CONVENTIONAL METHODS ARE TIME-CONSUMING, COSTLY, AND INSUFFICIENT TO SUPPORT A RESILIENT AND SUSTAINABLE U.S. DRUG SUPPLY. THIS PROJECT PROPOSES THE ESTABLISHMENT OF A FIRST-IN-CLASS, AI-POWERED SELF-DRIVING LABORATORY PLATFORM IN MISSISSIPPI TO ACCELERATE THERAPEUTIC DISCOVERY AND ENABLE NEXT-GENERATION PHARMACEUTICAL MANUFACTURING. THE PROPOSED SYSTEM INTEGRATES ARTIFICIAL INTELLIGENCE (AI), MACHINE LEARNING (ML), AUTOMATION, AND ADVANCED MANUFACTURING INTO A CLOSED-LOOP, DATA-DRIVEN FRAMEWORK. BY LEVERAGING PREDICTIVE MODELING AND REAL-TIME EXPERIMENTAL FEEDBACK, THESE SELF-DRIVING LABORATORIES WILL SIGNIFICANTLY REDUCE EXPERIMENTAL BURDEN, STREAMLINE WORKFLOWS, AND ENHANCE DECISION-MAKING ACROSS THE DRUG DEVELOPMENT LIFECYCLE. THE RESEARCH FOCUSES ON THREE KEY OBJECTIVES: (1) APPLYING AI/ML TO IDENTIFY NOVEL THERAPEUTIC CANDIDATES, INCLUDING SMALL MOLECULES AND BIOLOGICS, PARTICULARLY FOR TARGETS LACKING STRUCTURAL INFORMATION; (2) ADVANCING AI-DRIVEN DESIGN OF MICRO- AND NANOMEDICINE SYSTEMS TO OPTIMIZE DRUG DELIVERY PROPERTIES AND REPLACE TRIAL-AND-ERROR APPROACHES; AND (3) INTEGRATING AI/ML WITH 3D PRINTING AND BIOPRINTING FOR THE DEVELOPMENT OF PERSONALIZED DOSAGE FORMS AND IMPROVED MANUFACTURING PROCESSES. EXPECTED OUTCOMES INCLUDE THE CREATION OF AN END-TO-END AI-ENABLED PLATFORM SPANNING DRUG DISCOVERY, FORMULATION, AND MANUFACTURING, ALONG WITH TRANSFERABLE TOOLS AND DATASETS FOR BROADER ADOPTION. THE PROJECT WILL SUPPORT TRANSLATION TO INDUSTRIAL APPLICATIONS THROUGH COLLABORATION WITH ACADEMIC, INDUSTRY, AND REGULATORY STAKEHOLDERS. THIS WORK WILL ENHANCE THE EFFICIENCY, SUSTAINABILITY, AND SCALABILITY OF PHARMACEUTICAL INNOVATION, STRENGTHEN THE U.S. DRUG SUPPLY CHAIN, AND MITIGATE FUTURE SHORTAGES. ADDITIONALLY, WORKFORCE DEVELOPMENT IS ANOTHER KEY OUTCOME, AS TRAINEES AND RESEARCHERS WILL GAIN EXPERTISE IN AI-DRIVEN PHARMACEUTICAL SCIENCES, POSITIONING THEM FOR LEADERSHIP ROLES IN ACADEMIA AND INDUSTRY. ULTIMATELY, THE PROJECT ESTABLISHES SELF-DRIVING LABORATORIES AS A TRANSFORMATIVE PARADIGM FOR ACCELERATING DRUG DISCOVERY AND ENABLING RESILIENT, ADVANCED PHARMACEUTICAL MANUFACTURING IN THE UNITED STATES.

EARLY CHILDHOOD HEALTH PROMOTION SYSTEM FOR HIGH NEED PROGRAM

IMPROVE EXISTING AIRPORT

CENTER OF RESEARCH EXCELLENCE IN NATURAL PRODUCTS NEURO*

SPIRULINA ORAL SUPPLEMENT FOR ENHANCING HOST RESILIENCE TO VIRUS INFECTION

LASER STANDOFF DETECTION OF BURIED HAZARDS USING ACOUSTIC/SEISMIC STIMULI

CHILD NUTRITION DISCRETIONARY GRANTS LIMITED AVAILABILITY

RII TRACK-2 FEC: FEEDING AND POWERING THE WORLD - CAPTURING SUNLIGHT TO SPLIT WATER AND GENERATE FERTILIZER AND FUELS

ANXIOLYTIC EFFECTS AND ABUSE OF BZ RECEPTOR LIGANDS

¿¿DEVELOPMENT OF SAFER DRUGS FOR MALARIA AND LEISHMANIASIS IN US TROOPS, CIVILIAN PERSONNEL AND TRAVELERS¿¿

CENTER FOR PSYCHIATRIC NEUROSCIENCE

RYAN WHITE PART C OUTPATIENT EIS PROGRAM

COBRE PHASE III TRANSITIONAL CENTER

MS CENTER FOR CLINICAL AND TRANSLATIONAL RESEARCH - PROJECT SUMMARY/ABSTRACT, OVERALL MISSISSIPPI (MS) CURRENTLY STANDS AS THE LEAST HEALTHY STATE IN THE U.S., PLAGUED BY ALARMINGLY HIGH RATES OF INFANT AND MATERNAL MORTALITY AND CHRONIC DISEASE. WHILE POCKETS OF IMPROVEMENT OFFER HOPE, THE STATE STILL FACES MONUMENTAL STRUCTURAL AND ACCESS ISSUES. THUS, THE MAJOR FOCUS OF THE DURING PHASE III OF THE MISSISSIPPI CENTER FOR CLINICAL AND TRANSLATIONAL RESEARCH (MCCTR) IS TO LEVERAGE AN INTEGRATED CLINICAL AND TRANSLATIONAL (C/T) RESEARCH PROGRAM ACROSS UMMC AND ITS PARTNER INSTITUTIONS (MS STATE UNIVERSITY, UNIVERSITY OF SOUTHERN MS, OLE MISS, AND TOUGALOO COLLEGE) TO ADDRESS MAJOR CHRONIC DISEASES (E.G., OBESITY DIABETES, CKD, HYPERTENSION, HEART DISEASE, CANCER, MATERNAL/FETAL DISORDERS, AND DEMENTIA) IMPACTING MISSISSIPPIANS. THE MCCTR IMPACT ON C&T RESEARCH WILL ALSO BE GREATLY ENHANCED BY THE INVOLVEMENT OF OUR COLLABORATIVE PARTNERS: THE LOUISIANA C&T SCIENCE CENTER, THE MAYO CLINIC CENTER FOR C&T SCIENCE AND THE UNIVERSITY OF ALABAMA-BIRMINGHAM CENTER FOR C&T SCIENCE AND THE IDEA STATE CONSORTIUM FOR CLINICAL RESEARCH (ISCORE), OUR NEWLY FORMED PBRN CALLED THE “MISSISSIPPI PRIMARY CARE INNOVATION NETWORK”, AND FOUR NIGMS-SUPPORTED COBRES AT UMMC THAT ARE ALIGNED WITH THE MAJOR GOALS OF THE MCCTR. THE AIMS BELOW WILL BE ACCOMPLISHED USING OUR EFFECTIVE ADMINISTRATIVE CORE STRUCTURE AND GUIDED BY ADVISORY COMMITTEES AND PERFORMED BY OUR CORES: AIM 1: LEVERAGE A GOVERNANCE PLAN FOR THE MCCTR TO OVERSEE AN INTEGRATED C&T RESEARCH PROGRAM ACROSS UMMC AND ITS PARTNER INSTITUTIONS TO ADDRESS MAJOR CHRONIC DISEASES IMPACTING MISSISSIPPIANS. ALSO, ENHANCE OUR MARKETING TEAM AND TRACKING AND EVALUATION SPECIALISTS TO HELP MAXIMIZE ITS MCCTR EFFECTIVENESS AND EFFICIENCY TO REACH C&T FACULTY AT MISSISSIPPI INSTITUTIONS AND CTSA/CTR PARTNERS. AIM 2: UTILIZE HR CORE TO MANAGE ALL RESEARCH PROJECTS (1YR-PILOT PROJECT, 2-YR DEVELOPMENTAL PROJECTS, AND MULTI-INSTITUTIONAL COLLABORATIVE PROJECT) WITH THE GOAL OF DEVELOPING A C&T WORKFORCE, STRENGTHENING INVESTIGATOR-INITIATED C&T RESEARCH, AND INCREASING THE VOLUME/IMPACT OF CLINICAL TRIALS AND STUDIES WITHIN MCCTR’S NETWORK. AIM 3: EXPAND OUR COMMUNITY ENGAGEMENT AND OUTREACH (CEO) CORE TO ENHANCE ACTIVE ENGAGEMENT WITH OUR COMMUNITY ADVISORY BOARD, MS STATE EXTENSION SERVICE, PBRN CALLED THE “MISSISSIPPI PRIMARY CARE INNOVATION NETWORK”, AND MISSISSIPPI’S URBAN AND RURAL COMMUNITIES. AIM 4: ENHANCE OUR PROFESSIONAL DEVELOPMENT CORE (PDC) THAT PROVIDES MENTORSHIP AND SUPPORT IN CHRONIC DISEASE RESEARCH, INCLUDING RURAL AND CEO RESEARCH, TO JUNIOR FACULTY MEMBERS OF MCCTR PARTNER INSTITUTIONS, PROMOTING THEIR DEVELOPMENT INTO INDEPENDENT INVESTIGATORS. AIM 5: UTILIZE OUR RESEARCH DESIGN, COMPLIANCE, AND DATA MANAGEMENT (RDCD) CORE TO PROVIDE ACCESSIBLE, RIGOROUS RESEARCH DESIGN, ANALYTIC, AND DATA SUPPORT SERVICES, AND COMPLIANCE SUPPORT FOR MCCTR FACULTY. AIM 6: LEVERAGE OUR RESEARCH SERVICES CORE TO TRAIN, MENTOR AND SUPPORT INVESTIGATORS IN C&T RESEARCH AND TO ENHANCE THE DEVELOPMENT AND IMPLEMENTATION OF C&T RESEARCH PROJECTS UTILIZING MODERN TOOLS SUCH AS TELEMEDICINE AND OUR UNIQUE COHORT STUDIES AT UMMC.

CARDIORENAL AND METABOLIC DISEASES RESEARCH CENTER - PROJECT SUMMARY/ABSTRACT CARDIOVASCULAR (CV), RENAL AND METABOLIC DISEASES ARE HIGHLY PREVALENT IN THE U.S., ESPECIALLY IN MISSISSIPPI. WE ESTABLISHED THE CARDIORENAL AND METABOLIC DISEASES RESEARCH CENTER (CMDRC) AT THE UNIVERSITY OF MISSISSIPPI MEDICAL CENTER TO BRING TOGETHER A MULTIDISCIPLINARY GROUP OF BASIC, CLINICAL AND POPULATION SCIENTISTS WORKING ON CV, RENAL, AND METABOLIC DISEASES. UNDERSTANDING THE COMPLEX RELATIONSHIP BETWEEN THESE CHRONIC DISEASES REQUIRES THE COMBINED EFFORTS OF BASIC, CLINICAL AND POPULATION SCIENTISTS USING INNOVATIVE MULTIDISCIPLINARY INTEGRATIVE APPROACHES TO RESEARCH AND STATE-OF-THE-ART TECHNOLOGIES THAT FACILITATE DISCOVERY. THE MOLECULAR BASES FOR INTERDEPENDENCE OF CV, RENAL, AND METABOLIC DISEASES HAVE CLASSICALLY BEEN STUDIED VIA GENOMICS, TRANSCRIPTOMICS, AND PROTEOMICS PLATFORMS THAT ASSESS DNA SEQUENCES AND LEVELS OF RNA AND PROTEIN EXPRESSION. WHILE DATA GENERATED FROM THESE STUDIES ARE INFORMATIVE, REGULATION OF COMPLEX BIOLOGICAL SYSTEMS ALSO REQUIRES UNDERSTANDING PROTEIN ACTIVITY. PROTEIN KINASES ARE CENTRAL TO GOVERNING PROTEIN ACTIVITY NETWORKS AND LINK SEVERAL REGULATORY ELEMENTS, INCLUDING TRANSCRIPTION FACTORS, CHAPERONES, AND STRUCTURAL PROTEINS. THE KINOME REFERS TO THE BROAD-BASED ACTIVITY OF THE COMPLETE SET OF PROTEIN KINASES. SEVERAL METHODS HAVE RECENTLY BEEN DEVELOPED TO STUDY THE KINOME IN LIGHT OF THE VAST ACTIVITY OF PROTEIN KINASES. ONE OF THESE NEW TECHNOLOGIES IS THE PAMCHIP WHICH USES HUNDREDS OF ~13 RESIDUE-LONG REPORTER PEPTIDES WHICH ARE PHOSPHORYLATED WITH SAMPLES DERIVED FROM CELL CULTURES, TISSUES, OR CLINICAL BIOPSIES. THE DEGREE OF PHOSPHORYLATION IS MEASURED IN REAL-TIME USING FLUORESCENT ANTIBODIES. THIS TECHNOLOGY IS ENCOMPASSED IN THE PAMSTATION 12 FROM PAMGENE. THIS EQUIPMENT SUPPLEMENT APPLICATION IS FOR FUNDS TO PURCHASE A PAMSTATION 12 FOR THE CMDRC. THE ACQUISITION OF THIS STATE-OF-THE-ART SYSTEM WILL ALLOW INVESTIGATORS OF THE PARENT COBRE TO DETERMINE THE ROLE OF THE KINOME IN THE AREAS OF CV, RENAL, AND METABOLIC DISEASES. THIS NEW EQUIPMENT WILL ALSO INCREASE THE SOPHISTICATION OF EXPERIMENTAL APPROACHES AND STRENGTHEN FUTURE NIH GRANTS FROM CMDRC INVESTIGATORS AS WELL AS OTHER INVESTIGATORS AT UMMC, INCLUDING THOSE SUPPORTED BY OTHER NIGMS FUNDED IDEA CENTERS. THE CMDRC HAS BEEN A MAJOR DRIVER FOR MARKED EXPANSION OF CARDIORENAL AND METABOLIC DISEASES RESEARCH IN MISSISSIPPI. THIS LARGE EQUIPMENT GRANT WILL AMPLIFY AND ENSURE SUSTAINABILITY OF OUR EFFORTS TO DEVELOP A HIGHLY PRODUCTIVE CMDRC DEDICATED TO IMPROVING LIVES THROUGH RESEARCH, DISCOVERY, AND INNOVATION.

REMOTE INFRASONIC MONITORING OF NATURAL HAZARDS

THE UNIVERSITY OF MISSISSIPPI THROUGH THE MISSISSIPPI SMALL BUSINESS DEVELOPMENT CENTER NETWORK MSBDCN AND THE RESOURCES FOR INTERNATIONAL SUCCESS AND EXPANSION RISE CENTER AT OLE MISS WILL IMPLEMENT THE UNIVERSITY OF MISSISSIPPI SMALL BUSINESS TECHNOLOGY PROGRAM OVER A 48 MONTH PERIOD. THE PROJECT REQUESTS FIVE MILLION IN CONGRESSIONALLY DIRECTED SPENDING.PROJECT DESCRIPTION.THE RISE CENTER AT OLE MISS HELPS MISSISSIPPI SMALL BUSINESSES USE NEW TECHNOLOGIES TO STRENGTHEN OPERATIONS AND GROW. THIS PROJECT WILL EXPAND THOSE SERVICES STATEWIDE BY HELPING BUSINESSES COMPETE FOR FEDERAL FUNDING AND CONTRACTING OPPORTUNITIES IMPROVE CYBERSECURITY ADOPT TECHNOLOGIES SUCH AS ARTIFICIAL INTELLIGENCE AND AUTOMATION AND PREPARE TO SECURE INVESTMENT AND OTHER FINANCING. BUILDING ON THE RISE CENTERS SUCCESSFUL TRACK RECORD SERVICES WILL BE DELIVERED THROUGH THE MISSISSIPPI SMALL BUSINESS DEVELOPMENT CENTER NETWORK AND REGIONAL PARTNERS TO REACH BUSINESSES ACROSS MISSISSIPPI.ACTIVITIES AND BUDGET ALIGNMENT.FUNDING SUPPORTS FOUR PROGRAM AREAS. HELPING BUSINESSES COMMERCIALIZE NEW TECHNOLOGIES AND COMPETE FOR FEDERAL OPPORTUNITIES. IMPROVING CYBERSECURITY AND TECHNOLOGY ADOPTION. PREPARING BUSINESSES TO ACCESS CAPITAL. EXPANDING STATEWIDE SERVICE DELIVERY. THE FIVE MILLION BUDGET INCLUDES PERSONNEL SPECIALIZED TECHNICAL CONSULTING REGIONAL OUTREACH TECHNOLOGY TOOLS PROGRAM OPERATIONS PARTICIPANT SUPPORT AND APPROVED INDIRECT COSTS.PROJECT TIMELINE.YEAR 1 FOCUSES ON BUILDING PROGRAM CAPACITY BY HIRING SPECIALIZED STAFF ESTABLISHING STATEWIDE SYSTEMS AND PERFORMANCE MEASURES EXPANDING REGIONAL DELIVERY AND LAUNCHING AN INITIAL STATEWIDE INNOVATION ACTIVITY. YEAR 2 EXPANDS SERVICES THROUGH AN INNOVATION PATHWAY SECTOR FOCUSED ACCELERATOR PROGRAMMING AND BUSINESS PERFORMANCE INITIATIVES. YEAR 3 SCALES THESE EFFORTS BY HOSTING STATEWIDE TECHNOLOGY EVENTS EXPANDING ACCELERATOR PROGRAMS AND IMPLEMENTING REGULAR IMPACT REPORTING. YEAR 4 FOCUSES ON LONG TERM SUSTAINABILITY BY ESTABLISHING RECURRING STATEWIDE PROGRAMS AND PRODUCING A CO

CN NFSMI

MISSISSIPPI DRUG-USE REDUCTION PROGRAM

CN NFSMI

CN NFSMI

CN NFSMI

CN NFSMI