Regents Of The University Of Colorado

CIRES FIVE-YEAR COOPERATIVE AGREEMENT PROPOSAL RENEWAL

THE PROPOSAL IS TO ESTABLISH A NOAA COOPERATIVE INSTITUTE FOR EARTH SYSTEM RESEARCH AND DATA SCIENCE AT THE UNIVERSITY OF COLORADO, BOULDER (UC) FOR 2022-2027 TO FULFILL NOAAS VISION OF HEALTHY ECOSYSTEMS, COMMUNITIES, AND ECONOMIES THAT ARE RESILIENT IN THE FACE OF CHANGE. THE UNIVERSITY OF COLORADO PROPOSES A COMPREHENSIVE, INNOVATIVE, AND FLEXIBLE RESEARCH PROGRAM TO ACHIEVE NOAAS VISION AND GOALS, WITH A FOCUS ON EARTH SYSTEM RESEARCH AND DATA SCIENCE. THE COOPERATIVE INSTITUTE WILL EMPLOY WORLD-CLASS RESEARCHERS TO CONDUCT SCIENCE IN SERVICE TO SOCIETY AND IN PARTNERSHIP WITH NOAA. THE COOPERATIVE INSTITUTE WILL BE SUPPORTED BY A ROBUST INFRASTRUCTURE COMMITTED TO EQUITY, EDUCATION, AND OUTREACH. THE COOPERATIVE INSTITUTE PROPOSES TO ADDRESS THE FOLLOWING THEMES OVER THE COURSE OF THIS 5-YEAR AWARD: 1) FUTURE ATMOSPHERE, 2) CLIMATE SCIENCE AND PREDICTION, 3) EARTH SYSTEM DATA SCIENCE, STEWARDSHIP, AND APPLICATIONS, 4) REGIONAL SCIENCE AND APPLICATIONS, 5) SCIENTIFIC OUTREACH, EDUC

COOPERATIVE INSTITUTE FOR RESEARCH IN ENVIRONMENTAL SCIENCES

CIRES FIVE-YEAR COOPERATIVE AGREEMENT PROPOSAL

CIRES TASK IV NPP VIIRS MASLANIK

CANCER CENTER SUPPORT GRANT

A PROPOSAL TO LEAD THE SPACE PLATFORMS REQUIREMENTS WORKING GROUP TO PRIORITIZE FUTURE NOAA SATELLITE OBSERVATION PARAMETERS.

PREP BOULDER

COLORADO CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTE (UL1)

UNIVERSITY OF COLORADO BOULDER CARES ACT HIGHER EDUCATION EMERGENCY RELIEF FUND - INSTITUTIONAL PORTION

COLORADO CLINICAL AND TRANSATIONAL SCIENCES INSTITUTE

NIST-CU COOPERATIVE AGREEMENT 2015-2020 (FOR JILA)

COLORADO CLINICAL AND TRANSLATIONAL SCIENCES INSTITUTE

PURPOSE: THE PURPOSE OF THIS COOPERATIVE AGREEMENT TO PROVIDE UNDERGRADUATE/GRADUATE RESEARCHERS, INDIVIDUALS WITH BACHELORS OR MASTER'S DEGREES, POST-DOCTORAL ASSOCIATES, SENIOR RESEARCH FELLOWS AND ACADEMIC AFFILIATES WITH FELLOWSHIP OPPORTUNITIES AND FINANCIAL ASSISTANCE TO OBTAIN LABORATORY EXPERIENCES AND AID IN DEVELOPING COLLABORATIVE RESEARCH RELATIONSHIPS WITH NIST STAFF WITHIN THE NIST BOULDER LABORATORY.ACTIVITIES TO BE PERFORMED: PREP SEEKS TO ENCOURAGE THE GROWTH AND PROGRESS OF SCIENCE AND ENGINEERING IN THE UNITED STATES, INCLUDING THE ENCOURAGEMENT OF WOMEN AND MINORITY RESEARCHERS SEEKING TO FURTHER THEIR PROFESSIONAL DEVELOPMENT, AND TO NURTURE RESEARCHERS AND POST-DOCTORAL ASSOCIATES CONSIDERED TO BE POTENTIAL FUTURE NIST EMPLOYEES.EXPECTED OUTCOMES: THE OBJECTIVES OF THE PREP PROGRAM ARE TO: 1) ENCOURAGE THE GROWTH AND PROGRESS OF SCIENCE AND ENGINEERING IN THE UNITED STATES BY PROVIDING RESEARCH OPPORTUNITIES FOR PREP RESEARCHERS WITH NIST SCIENTISTS AND ENGINEERS AND EXPOSING THEM TO CUTTING-EDGE RESEARCH AND DEVELOPMENT (R&D); 2) PROMOTE THE PURSUIT OF DEGREES OR PROFESSIONAL DEVELOPMENT, AS APPLICABLE, FOR PREP RESEARCHERS; AND 3) PROMOTE DIVERSITY AND EQUITY IN STEM.INTENDED BENEFICIARIES: NIST AND NIST RESEARCHERS, AND UNDERGRADUATE/GRADUATE RESEARCHERS, INDIVIDUALS WITH BACHELORS OR MASTER'S DEGREES, POST-DOCTORAL ASSOCIATES, SENIOR RESEARCH FELLOWS AND ACADEMIC AFFILIATES, EMPLOYED BY OR AFFILIATED WITH THE UNIVERSITIES.SUBRECIPIENT ACTIVITIES: THE RECIPIENT DOES NOT INTEND TO SUBAWARD FUNDS.

SCIENCE AND TECHNOLOGY CENTER ON REAL-TIME FUNCTIONAL IMAGING (STROBE)

UNIVERSITY OF COLORADO BOULDER CARES ACT HIGHER EDUCATION EMERGENCY RELIEF FUND

2014-NIST-PREP-BOULDER 01

HEER - UNIVERSITY OF COLORADO DENVER

NIST/CU COOPERATIVE AGREEMENT 2010-2015

NIST PROFESSIONAL RESEARCH EXPERIENCE PROGRAM (PREP) POST-DOCTORAL LEVEL

PURPOSE: THE PURPOSE OF THIS AWARD IS TO SUPPORT ACTIVITIES OF JILA, THE NIST-UNIVERSITY OF COLORADO BOULDER (UCB) JOINT RESEARCH INSTITUTE. JILA CONDUCTS RESEARCH TO ADVANCE UNDERSTANDING OF QUANTUM PHYSICS THAT PROVIDES THE FOUNDATION FOR QUANTUM-ENHANCED PRECISION MEASUREMENT, QUANTUM COMPUTATION AND SIMULATION, AND QUANTUM NETWORKING, FOR APPLICATIONS IN CHEMISTRY, BIOLOGY, AND DIVERSE ASPECTS OF FUNDAMENTAL PHYSICS. UCB PERSONNEL WILL PERFORM THIS RESEARCH IN CLOSE COLLABORATION WITH STAFF MEMBERS OF THE NIST PHYSICAL MEASUREMENT LABORATORY (PML) WHO ARE ENGAGED AS JILA FELLOWS. ACTIVITIES TO BE PERFORMED: RESEARCH ACTIVITIES WILL BE PERFORMED IN THE AREAS OF QUANTUM INFORMATION SCIENCE AND TECHNOLOGY; ATOMIC, MOLECULAR, AND OPTICAL PHYSICS; MANY-BODY QUANTUM PHYSICS; NANOSCIENCE; CHEMICAL PHYSICS; AND BIOPHYSICS. ACTIVITIES WILL INCLUDE, FOR EXAMPLE, EXPERIMENTAL INVESTIGATIONS OF FUNDAMENTAL QUANTUM SYSTEMS, DEVELOPMENT OF MEASUREMENT TECHNIQUES THAT EXPLOIT QUANTUM BEHAVIOR, AND DEVELOPMENT OF PRECISION MEASUREMENT TOOLS. JILA WILL CONTINUE PROGRAMS TO SUPPORT PRESTIGIOUS FELLOWSHIPS FOR THE ?BEST AND BRIGHTEST? GRADUATE STUDENTS AND POST-DOCTORAL ASSOCIATES AVAILABLE GLOBALLY. JILA WILL ALSO MAINTAIN SEMINARS WITH SPEAKERS OF INTERNATIONAL REPUTATION, AND WILL CONTINUE A ROBUST VISITING FELLOWS PROGRAM TO BRING INTERNATIONALLY RECOGNIZED LEADERS IN QUANTUM SCIENCE TO UCB. EXPECTED OUTCOMES: JILA RESEARCH RESULTS WILL ADVANCE UNDERSTANDING IN THE AREAS OF FUNDAMENTAL QUANTUM PHYSICS, AND QUANTUM INFORMATION SCIENCE AND TECHNOLOGY. IT WILL PROVIDE FOR IMPROVEMENTS TO PRECISION MEASUREMENTS ACROSS A BROAD RANGE OF APPLICATIONS IN PHYSICS, CHEMISTRY, AND BIOLOGY. A PARTICULAR OUTCOME WILL BE IMPROVED MEASUREMENT OF FUNDAMENTAL CONSTANTS THAT HELP TO TEST FUNDAMENTAL PHYSICAL THEORIES AND THEIR LIMITATIONS. INTENDED BENEFICIARIES: JILA RESEARCH WILL PROVIDE INNOVATIONS THAT SUPPORT ON-GOING GROWTH OF QUANTUM INDUSTRIES AND THE ASSOCIATED SUPPLY CHAINS. FOR EXAMPLE, THOSE DEVELOPING QUANTUM COMPUTERS WITH CAPABILITIES FAR EXCEEDING EVEN THE WORLD'S BEST EXISTING SUPERCOMPUTERS. JILA RESEARCH WILL SUPPORT THE QUANTUM PHYSICS RESEARCH ECOSYSTEM WITH IMPROVED TECHNIQUES, TOOLS, AND ADVANCED KNOWLEDGE. THE STUDENTS AND POSTDOCTORAL ASSOCIATES SUPPORTED BY JILA WILL PROVIDE A HIGHLY TRAINED WORKFORCE NECESSARY TO MEET THE NEEDS OF THE RAPIDLY DEVELOPING QUANTUM ECONOMY. SUBRECIPIENT ACTIVITIES: THE RECIPIENT DOES NOT INTEND TO SUB-AWARD FUNDS.

QLCI-CI: NSF QUANTUM LEAP CHALLENGE INSTITUTE FOR ENHANCED SENSING AND DISTRIBUTION USING CORRELATED QUANTUM STATES

COOPERATIVE RESEARCH PROGRAM FOR THE QUANTUM PHYSICS DIVISION

DIFFERENTIAL DIAGNOSIS IN LEARNING DISABILITIES

THE MOLECULAR PATHOGENESIS OF VARICELLA ZOSTER VIRUS INFECTION

MOUNTAIN AND PLAINS EDUCATION AND RESEARCH CENTER

A NATIONAL CENTER FOR DIGITAL HEALTH INFORMATICS INNOVATION

HEER - UNIVERSITY OF COLORADO DENVER

CARES ACT - 2

SPORE IN LUNG CANCER

NEW APPROACHES FOR EMPOWERING STUDIES OF ASTHMA IN POPULATIONS OF AFRICAN DESCENT

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

EXTENSION TO THE JILA BUILDING

ADAPTATIONS TO HYPOXIA

COLORADO CLINICAL NUTRITION RESEARCH UNIT

GRADUATE RESEARCH FELLOWSHIP PROGRAM (GRFP)

CARES ACT

GRADUATES RESEARCH FELLOWSHIP PROGRAM (GRFP)

CENTER FOR NATIVE ORAL HEALTH RESEARCH (CNOHR)

JILA PFC: BRIDGING THEGAP FROM FEW-BODY TO MANY-BODY THROUGH QUANTUM CONTROL

RESEARCH INFRASTRUCTURE: MID-SCALE RI-1 (M1:IP): THE NATIONAL QUANTUM NANOFAB -NEW QUANTUM TECHNOLOGIES ARE POISED TO TRANSFORM FIELDS OF BROAD SOCIETAL IMPACT IN COMPUTING, SENSING, AND COMMUNICATIONS. HOWEVER, THERE IS A SIGNIFICANT GAP BETWEEN FUNDAMENTAL LABORATORY DEMONSTRATIONS AND THE FABRICATION OF QUANTUM DEVICES THAT CAN BE BUILT INTO INSTRUMENTATION SUCH AS COMPUTERS, CLOCKS, NAVIGATION TOOLS, AND OPTICAL NETWORKS. SIMPLY PUT, WE DO NOT YET KNOW HOW TO BUILD THE MANUFACTURABLE QUANTUM DEVICES OF THE FUTURE, AND PARTICULARLY THOSE THAT WILL HARNESS QUANTUM PARTICLES LIKE ATOMS AND PHOTONS. THESE QUANTUM BUILDING BLOCKS ARE FUNDAMENTALLY SMALL AND NEW FABRICATION TECHNIQUES AT THE NANOSCALE WILL BE CRITICAL TO REALIZE THE DESIRED ADVANCES IN THESE FIELDS. THE NATIONAL QUANTUM NANOFAB (NQN) AT THE UNIVERSITY OF COLORADO BOULDER WILL ADDRESS THIS SHORTCOMING BY DEVELOPING ADVANCED NANOFABRICATION APPROACHES REQUIRED TO BUILD, CONTROL, AND CONNECT QUANTUM DEVICES WITH THEIR SUPPORTING INFRASTRUCTURE. IN THE BROADER QUANTUM LANDSCAPE, THE FOCUS OF NQN WILL BE ON THE NANOSCALE FABRICATION OF DEVICES BASED ON ATOMS AND PHOTONS WITH THE GOAL OF TRANSITIONING QUANTUM DISCOVERIES INTO FUNCTIONING QUANTUM DEVICES. IMPORTANTLY, NQN WILL BE AN OPEN-ACCESS NATIONAL FACILITY FOR ACADEMIC, GOVERNMENT AND INDUSTRIAL USERS. IT WILL ALSO BE AN INCLUSIVE HUB OF EDUCATION, TRAINING, AND OUTREACH FOR DIVERSE POPULATIONS RANGING FROM K-12 TO UNDERGRADUATE, GRADUATE AND COMMUNITY COLLEGE STUDENTS. TOGETHER, THESE MULTIPLE ASPECTS OF NQN WILL ACCELERATE THE SCIENTIFIC BREAKTHROUGHS, NANOFABRICATION TECHNIQUES, AND WORKFORCE DEVELOPMENT THAT WILL STRENGTHEN US LEADERSHIP IN QUANTUM SCIENCE, ENGINEERING, AND TECHNOLOGY. THE TEAM WILL BUILD AND IMPLEMENT A FACILITY AND ESSENTIAL NANOFABRICATION INSTRUMENTATION THAT WILL COMPRISE THE NATIONAL QUANTUM NANOFAB (NQN) AT THE UNIVERSITY OF COLORADO BOULDER. THE NQN FACILITY WILL ADVANCE THE FABRICATION, PROCESS DEVELOPMENT, AND INTEGRATION CHALLENGES ENCOUNTERED WITH QUANTUM DEVICES CONSTRUCTED FROM NEUTRAL ATOMS AND IONS THAT ARE INTERFACED AND ADDRESSED WITH OPTICAL PHOTONS. SUCH ATOMIC-PHOTONIC QUANTUM DEVICES ARE OF SIGNIFICANT INTEREST TO FUNDAMENTAL AND APPLIED RESEARCHERS AND ARE CRITICAL TO BROAD REACHING TECHNOLOGIES SUCH AS QUANTUM COMPUTING, ATOMIC CLOCKS, ELECTRIC AND MAGNETIC FIELD SENSORS, AND INERTIAL SENSORS. NQN WILL ADDRESS CRITICAL NANOFABRICATION NEEDS INCLUDING THOSE FOR CHIP-INTEGRATED NARROW LINEWIDTH LASERS, VISIBLE WAVELENGTH INTEGRATED PHOTONICS, INTEGRATED MODULATORS AND FREQUENCY SHIFTERS, NONLINEAR INTEGRATED OPTICS, METASURFACES AND GRATING STRUCTURES, INTEGRATED PHOTON DETECTORS, AND MANY MORE. THE FABRICATION REQUIREMENTS FOR SUCH QUANTUM DEVICES ARE UNCONVENTIONAL, INVOLVING MATERIALS BEYOND SILICON AND COMPLEX HETEROGENEOUS PROCESSES TO PRODUCE DEVICES THAT MUST INTEGRATE WITH ATOMIC SYSTEMS IN HIGH VACUUM, AND IN SOME CASES, AT CRYOGENIC TEMPERATURES. WITH ITS OPEN-ACCESS MODEL FOR ACADEMIC, INDUSTRIAL, AND GOVERNMENT PARTNERS, NQN WILL ACCELERATE CO-DESIGN AND DEVELOPMENT OF ATOMIC-PHOTONIC QUANTUM DEVICES, POSITIONING THE US TO LEAD IN THIS AREA. INTEGRAL TO ITS MISSION OF ADVANCING QUANTUM DEVICES AND HARDWARE, NQN WILL SERVE AS AN INCLUSIVE HUB OF EDUCATION, TRAINING, AND OUTREACH FOR DIVERSE STUDENT POPULATIONS AND THE WORKFORCE ESSENTIAL TO US LEADERSHIP IN QUANTUM SCIENCE AND ENGINEERING. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

AI INSTITUTE: INSTITUTE FOR STUDENT-AI TEAMING

COLORADO CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTE (UL1)

JILA PFC: MEASUREMENT, MANIPULATION, AND MEANING AT THE QUANTUM FRONTIER

ELEMENTARY PARTICLE PHYSICS AND HIGH ENERGY PHENOMENA

COLORADO ADOPTION/TWIN STUDY OF LIFESPAN BEHAVIORAL DEVELOPMENT & COGNITIVE AGING (CATSLIFE)

GRADUATE RESEARCH FELLOWSHIP PROGRAM (GRFP)

NOVEL ANTIOXIDANT THERAPEUTICS FOR SULFUR MUSTARD TOXICITY (U54)

NEURONEX: FROM ODOR TO ACTION: DISCOVERING PRINCIPLES OF OLFACTORY-GUIDED NATURAL BEHAVIOR

DEVELOPMENT OF ANTIDOTES FOR TOXIC GASES

GWAS IN FIBROSING INTERSTITIAL LUNG DISEASE

TRAUMA PRIMES CELLS

SPARTA: SUBCELLULAR PAN-OMICS FOR ADVANCED RAPID THREAT IDENTIFICATION

SUSTAINABLE WASH SYSTEMS

MULTIDISCIPLINARY RESEARCH TRAINING RESPIRATORY DISEASE

JAMES GREEN / UNIVERSITY OF COLORADOCOSMIC ORIGINS SPECTROGRAPH GTOSPECTROSCOPY IS AT THE HEART OF A

UNIVERSITY OF COLORADO SYSTEMS BIOTECHNOLOGY BUILDING

THE SUCCESSFUL OUTCOME OF THE OVERALL VISION FOR ACCESS WILL DELIVER AN INTEGRATED SIMULATION FRAMEWORK FOR THE COMPREHENSIVE AND AFFORDABLE DESIGN OF ES WITH QUANTIFIED UNCERTAINTY AND RELIABILITY ESTIMATES...

FULL PROPOSAL: ENVIRONMENTAL DATA SCIENCE INNOVATION AND INCLUSION LAB (ESIIL): ACCELERATING DISCOVERY BY FOSTERING AN OPEN AND DIVERSE EARTH DATA REVOLUTION -THE ENVIRONMENTAL DATA SCIENCE INNOVATION & INCLUSION LAB (ESIIL) IS A NEXT-GENERATION NSF SYNTHESIS CENTER LED BY THE UNIVERSITY OF COLORADO BOULDER IN COLLABORATION WITH NSF?S CYVERSE AT THE UNIVERSITY OF ARIZONA AND THE UNIVERSITY OF OSLO. ESIIL ENABLES A GLOBAL COMMUNITY OF ENVIRONMENTAL DATA SCIENTISTS TO LEVERAGE THE WEALTH OF ENVIRONMENTAL DATA AND EMERGING ANALYTICS TO DEVELOP SCIENCE-BASED SOLUTIONS TO SOLVE PRESSING CHALLENGES IN BIOLOGY AND OTHER ENVIRONMENTAL SCIENCES. ESIIL HOLDS INCLUSION AS A CORE PRINCIPLE AND METHOD FOR DIVERSIFYING ENVIRONMENTAL DATA SCIENCE AT A TIME WHEN SOCIETY NEEDS ALL PERSPECTIVES, AND SCIENCE NEEDS TO SERVE ALL. ESIIL?S RESEARCH COMMUNITY GENERATES DISCOVERIES AND NOVEL APPROACHES THROUGH: 1) CUTTING-EDGE TEAM SCIENCE, 2) INNOVATIVE TOOLS AND COLLABORATIVE CYBERINFRASTRUCTURE, 3) DATA SCIENCE EDUCATION AND TRAINING, AND 4) BUILDING INCLUSIVE PARTICIPATION AND DIVERSE GROUPS. THESE ACTIVITIES ADVANCE THE FRONTIER OF ENVIRONMENTAL DATA SCIENCE, A RAPIDLY EVOLVING DISCIPLINE BRIDGING THE COMPUTATIONAL, BIOLOGICAL, ENVIRONMENTAL, AND SOCIAL SCIENCES. ESIIL?S OPEN COLLABORATIVE AND SCALABLE ENVIRONMENT (CASE) CYBERINFRASTRUCTURE LOWERS BARRIERS TO SCIENTIFIC COLLABORATION THROUGH TAILORED USER EXPERIENCE, SEAMLESS CONNECTION TO CRITICAL DATA SOURCES, AND PREMIER CLOUD COMPUTING. ESIIL?S EDUCATION PROGRAM FACILITATES BROAD ACCESS TO ENVIRONMENTAL DATA SCIENCE SKILLS AND HELPS DEVELOP THE NEXT-GENERATION DATA-CAPABLE WORKFORCE. PARTNERSHIPS WITH TRIBAL COLLEGES AND MINORITY-SERVING INSTITUTIONS INCREASES DATA SKILLS AND KNOWLEDGE SHARING AMONG UNDERREPRESENTED GROUPS. THE ESIIL NETWORK, A DIVERSE COMMUNITY OF OVER 2,000 RESEARCHERS AND STUDENTS, IS A 21ST-CENTURY TEAM COMMITTED TO GENERATING DATA-INSPIRED DISCOVERIES THAT ENHANCE SOCIETAL AND ECOSYSTEM RESILIENCE. ESIIL?S VISION IS THAT CULTIVATING A DIVERSE AND INCLUSIVE COMMUNITY OF PRACTICE IS NEEDED TO PRODUCE INNOVATIVE BREAKTHROUGHS IN ENVIRONMENTAL DATA SCIENCE. INNOVATION SUMMITS EXPLORE GRAND CHALLENGES SUCH AS CONTINENTAL-SCALE ECOLOGY, ARTIFICIAL INTELLIGENCE FOR THE EARTH, ENVIRONMENTAL JUSTICE AND BIG DATA, AND ADAPTING TO OUR CHANGING WORLD. INCUBATOR WORKING GROUPS, POSTDOCS, AND LARGE-TEAM COLLABORATIONS GENERATE NEW DISCOVERIES, AND CROSS-SECTOR PARTNERSHIPS CATALYZE USE-INSPIRED RESEARCH THROUGH INNOVATION SUMMITS AND EARTH HACKATHONS. ESIIL COLLABORATIONS INCLUDE INDUSTRY, GOVERNMENT, AND NON-PROFIT PARTNERS, FACILITATING THE CO-PRODUCTION OF SCIENCE THAT HAS ENVIRONMENTAL POLICY, MANAGEMENT, AND TECHNOLOGICAL APPLICATIONS. THE NATIONAL ECOLOGICAL OBSERVATORY NETWORK (NEON), LONG TERM ECOLOGICAL RESEARCH (LTER) NETWORK, AND THE CRITICAL ZONE COLLABORATIVE NETWORK (CZ NET) ARE STRATEGIC DATA PARTNERS. ESIIL FACILITATES BEST PRACTICES IN TEAM SCIENCE AND CONDUCTS BASIC RESEARCH ON THE CORRELATES OF SCIENTIFIC PRODUCTIVITY AND CREATIVITY WITHIN DIVERSE SCIENTIFIC TEAMS. ESIIL ACCELERATES SCIENTIFIC INQUIRY BY SUPPORTING COMMUNITY-DEVELOPED AND HIGH-VALUE SOFTWARE AND DATA CUBES BRIDGE, FOR EXAMPLE, GROUND, AIRBORNE, AND SATELLITE DATA FROM DIVERSE OBSERVATORIES AND PLATFORMS. THESE TOOLS, CURATED DATASETS, AND REPRODUCIBLE AND REUSABLE WORKFLOWS ARE DEPLOYED ON ESIIL?S OPEN CYBERINFRASTRUCTURE. THE ESIIL STARS INTERNSHIP PROGRAM SUPPORTS STUDENTS AND FACULTY MEMBERS FROM INSTITUTIONS THAT PROMOTE UNDERREPRESENTED GROUPS IN STEM, PROVIDING DATA SKILLS TRAINING, RESEARCH EXPERIENCE, AND CAREER MENTORSHIP. INITIAL PARTNERS INCLUDE OGLALA LAKOTA COLLEGE, UNITED TRIBES TECHNICAL COLLEGE, AND METROPOLITAN STATE UNIVERSITY OF DENVER. THE ESIIL LEADERS PROGRAM SUPPORTS EMERGING SCIENTISTS FROM UNDERREPRESENTED COMMUNITIES BY FOSTERING LEADERSHIP SKILLS IN ENVIRONMENTAL DATA SCIENCE AND TEAM SCIENCE. CULTURALLY-RELEVANT CURRICULA INFORM TRAINING MODULES ALONG WITH AN OPEN TEXTBOOK THAT INTRODUCES NOVEL ANALYTICS FOR ENVIRONMENTAL DATA. BY HOSTING OPEN EDUCATION RESOURCES ON AN EXISTING LEARNING PORTAL, WITH A FOLLOWING OF OVER 200,000 USERS PER MONTH, ESIIL EDUCATION SCALES TO A GLOBAL AUDIENCE. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

SOUTHWEST HEALTH EXTENSION PARTNERSHIP TO ENHANCE RESEARCH DISSEMINATION (SHEPERD)

MOLECULAR TRANSDUCERS OF PHYSICAL ACTIVITY CONSORTIUM - COLORADO CLINICAL CENTER

COMPLEMENT MEDIATED REMODELING IN PULMONARY VASCULAR DISEASE

AIDS EDUCATION TRAINING CENTERS

TO SIMULATE TO STIMULATE WITH QUANTIFIED UNCERTAINTY, FROM PORE-PARTICLE-TO-CONTINUUMSCALES, A CLASS OF PROBLEMS INVOLVING GRANULAR FLOWS, LARGE DEFORMATIONS, AND FRACTURE/FRAGMENTATION OF UNBONDED AND BONDED PARTICULATE MATERIALS.

CENTER: JILA-PFC: COMPREHENSION AND CONTROL OF EMERGING COMPLEXITY AT THE QUANTUM FRONTIER -THE PHYSICS FRONTIERS CENTERS (PFC) AWARD TO THE JILA-PFC WILL DEVELOP AND ENHANCE CONTROL OVER LIGHT-MATTER INTERACTIONS TO ADVANCE INVESTIGATIONS OF AN ARRAY OF QUANTUM SYSTEMS OF INCREASING SIZE AND COMPLEXITY, RANGING FROM ASSEMBLIES OF ULTRACOLD ATOMS AND MOLECULES TO REAL MATERIALS AND BIOLOGICAL SYSTEMS. IN PURSUIT OF THESE ADVANCES, THE CENTER WILL DEVELOP AND APPLY A BROAD RANGE OF STATE-OF-THE-ART LIGHT SOURCES, INCLUDING SOURCES OF HIGHLY NON-CLASSICAL LIGHT, VACUUM ULTRAVIOLET LASERS AND SINGLE-PHOTON SOURCES, WHILE SIMULTANEOUSLY STRIVING TO IMPROVE COOLING AND MEASUREMENT TECHNIQUES. THESE NEW TOOLS WILL PERMIT RESEARCHERS TO SHED LIGHT ON OPEN QUESTIONS IN MANY-BODY PHYSICS RELEVANT TO DISCIPLINES RANGING FROM ATOMIC, MOLECULAR, AND OPTICAL (AMO) PHYSICS, TO CONDENSED MATTER PHYSICS, CHEMISTRY, AND BIOLOGY, AND TO ADVANCE FRONTIER PRECISION MEASUREMENTS TARGETING ISSUES IN FUNDAMENTAL PHYSICS. THE CENTER PROGRAM WILL ALSO PROVIDE GRADUATE STUDENTS AND POSTDOCTORAL SCHOLARS WITH CUTTING-EDGE EXPERTISE IN ATOMIC, MOLECULAR, AND OPTICAL (AMO) RELATED PHYSICS, AND IT WILL DEVELOP TOOLS AND TECHNIQUES TO ENHANCE THE NATION'S TECHNOLOGICAL INFRASTRUCTURE. THE JILA-PFC WILL CONTRIBUTE TO CONNECTING SCIENTIFIC COMMUNITIES BY HOSTING WORKSHOPS AND SCHOOLS AND THROUGH THE JILA VISITOR PROGRAM AND WILL CONTINUE ITS HIGHLY SUCCESSFUL EDUCATION AND OUTREACH EFFORTS TO ATTRACT THE NEXT GENERATION OF ALL STUDENTS INTO SCIENCE. THE JILA-PFC RESEARCH IS ORGANIZED AROUND FOUR INTERCONNECTED MAJOR ACTIVITIES THAT ARE IN TURN BUILT UPON CLOSELY INTERTWINED ASPECTS OF AMO PHYSICS. THE FIRST WILL FOCUS ON THE UNDERSTANDING AND MANIPULATION OF INTERACTIONS BETWEEN QUANTUM PARTICLES, FROM PRISTINE ARRAYS OF ULTRACOLD ATOMS AND MOLECULES MANIPULATED AT THE LEVEL OF INDIVIDUAL CONSTITUENT PARTICLES, TO COMPLEX MATERIALS STUDIED VIA ULTRAFAST PROBES. THE SECOND WILL BROADLY ADVANCE THE FRONTIER OF LIGHT-SCIENCE AND LIGHT-MATTER INTERACTIONS VIA THE DEVELOPMENT OF NOVEL LIGHT SOURCES. THE THIRD WILL SEEK TO CONTROL QUANTUM STATES OF INCREASINGLY COMPLEX MOLECULES FOR PRACTICAL AND FUNDAMENTAL APPLICATIONS INCLUDING SEARCHES FOR NEW PHYSICS BEYOND THE STANDARD MODEL. THE FOURTH AREA SEEKS OPPORTUNITIES TO EXCHANGE IDEAS AND TECHNOLOGIES THAT COULD LEAD TO PROJECTS OUTSIDE OF THE CENTRAL FOCUS OF THE JILA-PFC, BUT WHICH WOULD BENEFIT EITHER THE CORE WORK OF THE PFC OR OTHER AREAS OF SCIENCE. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

TRACK 2: CUSTOMIZED MULTI-TIER ASSISTANCE, TRAINING, AND COMPUTATIONAL HELP (MATCH) FOR END USER ACCESS TO CI -CUSTOMIZED MULTI-TIER ASSISTANCE, TRAINING, AND COMPUTATIONAL HELP (MATCH) PROVIDES END USER SUPPORT SERVICES AS PART OF THE ADVANCED CYBERINFRASTRUCTURE COORDINATION ECOSYSTEM: SERVICES & SUPPORT (ACCESS) PROGRAM. NSF-SUPPORTED COMPUTATIONAL CYBERINFRASTRUCTURE (CI) HAS BEEN HIGHLY SUCCESSFUL IN ADVANCING SCIENCE AND ENGINEERING OVER THE LAST FEW DECADES. THE USE OF CI HAS BECOME UBIQUITOUS IN RESEARCH, FROM TRADITIONAL FIELDS SUCH AS BIOINFORMATICS, COMPUTATIONAL CHEMISTRY AND ASTROPHYSICS, TO NEW AREAS INCLUDING TEXT INTERPRETATION, VISUAL ARTS AND OTHER HUMANITIES. THIS SHIFT IS NOT ONLY HAPPENING IN LARGE RESEARCH LABS AT MAJOR INSTITUTIONS, BUT ALSO INCREASINGLY AT SMALLER INSTITUTIONS WHERE RESEARCHERS ARE ALSO LOOKING TO MAKE USE OF CI RESOURCES. ALONG WITH THAT SUCCESS, THERE HAVE BEEN SIGNIFICANT CHANGES TO THE MAKEUP AND SIZE OF THE USER COMMUNITY, IMPROVEMENTS TO THE UNDERLYING COMPUTE, STORAGE, AND NETWORKING PLATFORMS USED, AND RADICALLY DIFFERENT METHODS BY WHICH RESEARCHERS AND CI PROFESSIONALS COMMUNICATE. THESE CHANGES REQUIRE A RETHINKING OF THE ROLE OF USER SUPPORT SERVICES AND HOW THEY ARE DELIVERED. TO ADDRESS THIS, MATCH PROPOSES A NEW MODEL FOR IMPLEMENTING USER SUPPORT SERVICES THAT WILL ENCOURAGE COST-EFFECTIVE, SCALABLE SUPPORT THAT CAN REACH A BROADER COMMUNITY. THE MATCH PROJECT DEVELOPS NEW APPROACHES, CONTENT, SERVICES, TECHNOLOGIES, AND EXPERTISE TO MAKE IT EASIER FOR NSF CI USERS TO FIND AND UTILIZE THE SPECIFIC LEVEL AND TYPE OF SUPPORT NEEDED TO EFFECTIVELY CARRY OUT THEIR RESEARCH. WITH THIS STRATEGY, THE MATCH PROJECT EXPANDS THE REACH AND IMPACT OF NSF CI, SERVING BOTH TRADITIONAL AND NEW MEMBERS OF THE RESEARCH COMPUTING AND DATA COMMUNITY. THE MATCH APPROACH COMPRISES THREE MAJOR THEMES: (1) LEVERAGE MODERN INFORMATION DELIVERY SYSTEMS TO SIMPLIFY USER INTERFACES; (2) LEVERAGE EXPERTS FROM THE COMMUNITY TO DEVELOP TRAINING MATERIALS AND INSTRUCTIONS THAT CAN DRAMATICALLY REDUCE THE USER LEARNING CURVE FOR SEVERAL INCREASINGLY IMPORTANT CI COMPUTATIONAL TECHNIQUES; AND (3) EMPLOY A MATCHMAKING SERVICE THAT WILL MAINTAIN A DATABASE OF SPECIALIST MENTORS AND STUDENT MENTEES THAT CAN BE MATCHED WITH PROJECTS TO PROVIDE THE DOMAIN-SPECIFIC EXPERTISE NEEDED TO LEVERAGE ACCESS RESOURCES. SPECIFICALLY, MATCH EMPLOYS A NEW ACCESS MATCH PORTAL (AMP) THAT WILL SERVE AS THE SINGLE FRONT DOOR FOR END USERS TO OBTAIN GUIDED SUPPORT AND ASSISTANCE. EXPERT-MONITORED Q&A PLATFORMS WILL ENSURE USER QUESTIONS ARE ACCURATELY ANSWERED AND ADDRESSED IN A TIMELY FASHION, AND EASY-TO USE USER INTERFACES SUCH AS OPEN ONDEMAND AND PEGASUS WILL BE ENHANCED AND IMPROVED TO FURTHER SIMPLIFY CI USE AND PROVIDE CONTEXT DIRECTED HELP WHEN PROBLEMS ARE ENCOUNTERED. THE SYSTEM MATCHES COMMUNITY EXPERTS WITH USER NEEDS TO CREATE DOCUMENTATION AND OTHER TRAINING MATERIALS OR PROVIDES PERSONAL INTERACTIONS THAT ADDRESS THE CURRENT REAL WORLD NEEDS OF ACCESS USERS. BY RESTRUCTURING END USER SUPPORT, MATCH CREATES A MULTI-LEVEL INFRASTRUCTURE CAPABLE OF SCALING TO ASSIST A GROWING RESEARCH COMMUNITY WITH INCREASINGLY SPECIALIZED SUPPORT NEEDS, ENABLING NEW DISCOVERIES AT THE FOREFRONT OF SCIENCE AND SOCIETY. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

PAUL CALABRESIS AWARD IN CLINICAL ONCOLOGY RESEARCH

ELEMENTARY PARTICLES AND HIGH ENERGY PHENOMENA TASKS A B C AND T

PURPOSE: CLOSE THE GAP FOR NON-DEGREE HOLDERS THROUGH FLEXIBLE SKILLS DEVELOPMENT. ACTIVITIES TO BE PERFORMED: 1). ESTABLISH QUANTUM LEARNING LAB (QULL) PROGRAM AT CNM-I TO PROVIDE PRACTICAL, HANDS-ON TRAINING THAT BLENDS PRACTICAL EXPERIENCE WITH THEORETICAL KNOWLEDGE AND HELPS FILL QUANTUM WORKFORCE GAPS. 2). BUILD QUANTUM AND DIGITAL SKILLS FOR TERTIARY AND POSTSECONDARY NON-DEGREE HOLDERS, INCLUDING ?LEARN AS YOU EARN? OPPORTUNITIES. LEVERAGE EXISTING ASSETS FOR APPRENTICESHIPS AND STACKABLE CREDENTIAL PROGRAMS. IMPLEMENT MOBILE OUTREACH DELIVERY PROGRAM (MOBILE COMPONENT OF QUANTUM LEARNING LAB. 3) ATTRACT/NURTURE TALENT THROUGH EXPANSIVE WORKFORCE PROGRAMMING. CONNECT ELEVATE QUANTUM WORKFORCE COLLABORATIVE (EQWC) MEMBERS WITH TALENT. SECURE ADDITIONAL FUNDING FOR ELEVATE QUANTUM WORKFORCE COLLABORATIVE FOR YEAR 3 AND BEYOND. 4). CREATE PATHWAYS FOR RURAL AND URBAN HIGH SCHOOL AND NON-DEGREE HOLDERS IN CO AND NM TO ACCESS QUANTUM EDUCATION AND CAREER PATHWAYS. LAUNCH AND SCALE PATHWAYS PROGRAMS. PILOT CAPACITY BUILDING PROGRAMS THROUGH ECONOMIC DEVELOPMENT ADMINISTRATION (EDA) FUNDING AND ELEVATE QUANTUM WORKFORCE COLLABORATIVE PARTNERSHIPS. EXPECTED OUTCOMES: 30,000 INDIVIDUALS ENGAGED IN QUANTUM INFORMATION TECHNOLOGY (QIT) PATHWAYS (TRAINING, RESKILLING, AWARENESS). 25 OR MORE GROUPS AND INSTITUTIONS ENGAGED IN QUANTUM INFORMATION TECHNOLOGY UPSKILLING, RESKILLING, AND CREDENTIALING PROGRAMS BY 2029. 30 OR MORE NEW INSTRUCTORS TRAINED AND DELIVERING QUANTUM TECHNICIAN AND QUANTUM INFORMATION TECHNOLOGY RELATED OFFERINGS FOR NON-DEGREE HOLDERS. 5 NOVEL AND SCALABLE TECHNICIAN TRAINING PROGRAMS ACROSS THE MOUNTAIN WEST. 10 OR MORE CAREER FAIRS CONNECTING ELEVATE QUANTUM WORKFORCE COLLABORATIVE MEMBERS TO TALENT. $5M OF NEW FUNDING GENERATED FROM ELEVATE QUANTUM WORKFORCE COLLABORATIVE PARTNERSHIPS TO SUPPORT INCLUDE INITIATIVES. 30 OR MORE HIGH SCHOOLS OFFERING CAREER-ALIGNED QUANTUM INFORMATION TECHNOLOGY CURRICULUM (400 OR MORE SENIORS/RISING ON PATHWAYS TO QUANTUM INFORMATION TECHNOLOGY DEGREE, APPRENTICESHIP OR INTERNSHIP). 300,000 STUDENTS/EDUCATORS REACHED VIA VARIOUS CHANNELS BY 2034. INTENDED BENEFICIARIES: EXPANDED AND BETTER-TRAINED TALENT POOLS IMPROVE CALIBER OF WORKFORCE FOR QUANTUM INDUSTRY EMPLOYERS. CURRENT AND PROSPECTIVE QUANTUM INDUSTRY EMPLOYEES, AS WELL AS CURRENT STUDENTS AND LEARNERS, BENEFIT FROM IMPROVED EDUCATIONAL INSTRUCTION, RESOURCES, AND CAREER PATHWAYS. NON-DEGREE HOLDERS GAIN ACCESS TO THE QUANTUM WORKFORCE THROUGH NEW EMPLOYER-ALIGNED PATHWAYS. SUBRECIPIENT ACTIVITIES: CENTRAL NEW MEXICO COMMUNITY COLLEGE, UNIVERSITY OF NEW MEXICO, AND SANDIA NATIONAL LABORATORIES WILL BUILD OUT THE QUANTUM LEARNING LAB. FRONT RANGE COMMUNITY COLLEGE (FRCC), FORT LEWIS COLLEGE, EMILY GRIFFITH TECHNICAL COLLEGE, AND NORTHERN ARIZONA UNIVERSITY WILL DEVELOP RAPID SKILLS BUILD TRAINING PROGRAMS. WOMANIUM WILL DEVELOP AND DEPLOY WORKFORCE PROGRAMMING. EMILY GRIFFITH, FRONT RANGE COMMUNITY COLLEGE, AND NORTHERN ARIZONA UNIVERSITY WILL LAUNCH, PILOT, AND SCALE PATHWAYS FOR HIGH SCHOOL AND NON-DEGREE HOLDERS ENTERING THE QUANTUM WORKFORCE.

THE EARLY LIFE EXPOSOME AND CHILDHOOD HEALTH - THE COLORADO HEALTHY START 3 COHORT STUDY

JILA AMO PHYSICS FRONTIER CENTER

GRADUATE RESEARCH FELLOWSHIP PROGRAM (GRFP) -THE NATIONAL SCIENCE FOUNDATION (NSF) GRADUATE RESEARCH FELLOWSHIP PROGRAM (GRFP) IS A HIGHLY COMPETITIVE, FEDERAL FELLOWSHIP PROGRAM. GRFP HELPS ENSURE THE VITALITY AND DIVERSITY OF THE SCIENTIFIC AND ENGINEERING WORKFORCE OF THE UNITED STATES. THE PROGRAM RECOGNIZES AND SUPPORTS OUTSTANDING GRADUATE STUDENTS WHO ARE PURSUING RESEARCH-BASED MASTER'S AND DOCTORAL DEGREES IN SCIENCE, TECHNOLOGY, ENGINEERING, AND MATHEMATICS (STEM) AND IN STEM EDUCATION. THE GRFP PROVIDES THREE YEARS OF FINANCIAL SUPPORT FOR THE GRADUATE EDUCATION OF INDIVIDUALS WHO HAVE DEMONSTRATED THEIR POTENTIAL FOR SIGNIFICANT RESEARCH ACHIEVEMENTS IN STEM AND STEM EDUCATION. THIS AWARD SUPPORTS THE NSF GRADUATE FELLOWS PURSUING GRADUATE EDUCATION AT THIS GRFP INSTITUTION. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

PROMOTE COMMERCIALLY FUNDING R & D AND TECHNOLOGY DEV IN THE FIELD OF BIOSERVE SPACE TECHNOLOGIE

ANTISOCIAL DRUG DEPENDENCE: GENETICS

ROUTES TO SUSTAINABILITY FOR NATURAL GAS DEVELOPMENT AND WATER AND AIR RESOURCES IN THE ROCKY MOUNTAIN REGION

HEALTH CENTER CLUSTER

BIOENERGETIC AND METABOLIC CONSEQUENCES OF THE LOSS OF GONADAL FUNCTION

SOFT MATERIALS RESEARCH CENTER

GENE ARRAY TECHNOLOGY CENTER FOR ALCOHOL RESEARCH (THE R-GAP)

14/21 ABCD-USA CONSORTIUM: RESEARCH PROJECT SITE AT CU BOULDER

INTEGRATED ATOM CHIP ENABLING TECHNOLOGY FOR PRECISION INERTIAL NAVAGITION SENSORS (PINS)

ETIOLOGY AND TREATMENT OF BILIARY ATRESIA AND INH

ROCKY MOUNTAIN CENTER FOR TOTAL WORKER HEALTH

RESUSCITATION STRATEGIES FOR ACHIEVING THROMBO-INFLAMMATORY HOMEOSTASIS

PREDICTION OF ACUTE MOUNTAIN SICKNESS USING A BLOOD BASED TEST

COLORADO RESOURCE CENTER FOR TRIBAL EPIDEMIOLOGY CENTERS - PROJECT SUMMARY OUR PROPOSAL TO ESTABLISH THE COLORADO RESOURCE CENTER FOR TRIBAL EPIDEMIOLOGY CENTERS CAPITALIZES ON THE CENTERS FOR AMERICAN INDIAN AND ALASKA NATIVE HEALTH’S 30+ YEAR, NATIONWIDE EXPERIENCE PROVIDING HIGH QUALITY, SCIENTIFICALLY GROUNDED, CULTURALLY INFORMED TRAINING AND TECHNICAL ASSISTANCE TO HUNDREDS OF NATIVE PROGRAMS THROUGH RESOURCE CENTERS THAT ADDRESSED NEEDS SIMILAR TO THOSE HIGHLIGHTED IN RFA-MD-21-003. WE MARRY THIS PROGRAMMATIC FOCUS WITH AN EQUALLY SUPERIOR RECORD OF PREPARING NATIVE INVESTIGATORS TO COMPETE FOR NIH- SPONSORED RESEARCH AND, THEREBY, ENHANCE THE NATURE, EXTENT, AND QUALITY OF THE SCIENCE UNDERTAKEN BY TRIBAL EPIDEMIOLOGY CENTERS (TECS). ACCORDINGLY, THE SPECIFIC AIMS OF OUR RESOURCE CENTER-TEC ARE TO: 1) JOINTLY PLAN, ISSUE, MONITOR, AND EVALUATE SUBAWARDS OF VARYING DEGREES OF SUPPORT TO EACH TEC CONSISTENT WITH LOCAL PRIORITIES AND NEEDS THAT PROGRESSIVELY EXPAND THEIR CAPACITY TO ENGAGE IN THE FULL SPECTRUM OF RESEARCH ACTIVITIES RANGING FROM DATA ACQUISITION, MANAGEMENT, AND ANALYSIS TO DATA VISUALIZATION, INTERPRETATION, AND REPORTING. 2) PROVIDE TECHNICAL ASSISTANCE TO EACH TEC TO DESIGN, IMPLEMENT, AND ANALYZE BOTH PRIMARY DATA ACQUISITION AS WELL AS SECONDARY DATA ANALYTIC STUDIES CONSISTENT WITH LOCAL PRIORITIES, AND TO PREPARE AS WELL AS DISSEMINATE LAY, PROGRAM, POLICY, AND SCIENTIFIC REPORTS OF FINDINGS TO A WIDE ARRAY OF AUDIENCES. 3) ENHANCE THE RESEARCH CAPACITY OF TEC PERSONNEL ACROSS ALL LEVELS OF PREPARATION BY DRAWING UPON AN EXTENSIVE BODY OF EXISTING INSTRUCTIONAL MATERIALS AND EXPERIENCE TO OFFER: A. BIMONTHLY INTERACTIVE, 2-HOUR DIDACTIC SESSIONS ON TIMELY DATA SCIENCE TOPICS; B. ON-LINE, SHORT-COURSE OFFERINGS THAT TARGET FOUNDATIONAL AND INTERMEDIARY KNOWLEDGE AND SKILLS REGARDING DATA COLLECTION, LINKAGE, MANAGEMENT, AND ANALYSIS; C. ONCE ANNUALLY, A 6-MONTH, MENTORED GRANT-WRITING COURSE FOR SENIOR TEC PERSONNEL—TAILORED TO THE INTERESTS AND PRIORITIES OF THEIR RESPECTIVE KEY STAKEHOLDERS—TO INCREASE THE NUMBER OF SUBMITTED AND FUNDED NIH R-SERIES GRANT APPLICATIONS, AND D. A YEAR-LONG RESEARCH CAREER DEVELOPMENT PROGRAM FOR EARLY-STAGE INVESTIGATORS TO ADD TO AND RETAIN THEM IN THE HEALTH DISPARITIES SCIENTIFIC WORKFORCE. 4) PROMOTE COLLABORATIVE RESEARCH BETWEEN THE TECS AND EXTERNAL INVESTIGATORS BY DISSEMINATING INFORMATION ABOUT SPONSORED RESEARCH OPPORTUNITIES AND RELATED RESOURCES AND BUILDING UPON OUR CURRENT SATELLITE CENTER RESEARCH NETWORK LED BY SENIOR, NIH-FUNDED AMERICAN INDIAN AND ALASKA NATIVE HEALTH DISPARITIES SCIENTISTS AT 7 ADJACENT MAJOR INSTITUTIONS, AND OTHER ORGANIZATIONAL PARTNERSHIPS. RECENT CALLS TO ACTION BY ADVOCATES UNDERSCORE THE IMPORTANT CONTRIBUTION OF RESEARCH TO ADDRESS THE HEALTH PRIORITIES OF NATIVE PEOPLES. THIS RESOURCE CENTER WILL ENABLE TECS TO BRING THIS VISION TO FRUITION.

COMPUTATIONAL BIOSCIENCE PROGRAM TRAINING GRANT

SPECIAL PROJECTS (CNS): NATIONAL CENTER FOR WOMEN AND INFORMATION TECHNOLOGY (NCWIT) - BUILDING THE COMPUTING WORKFORCE OF THE 21ST CENTURY

BASIC TO CLINICAL MOLECULAR NEUROBIOLOGY OF NICOTINIC RECEPTORS IN SCHIZOPHRENIA

THE INCLUDE PROJECT DOWN SYNDROME BIOREPOSITORY (DS-BIOREPOSITORY) - PROJECT SUMMARY. INDIVIDUALS WITH DOWN SYNDROME (DS), THE CONDITION CAUSED BY TRISOMY 21 (T21), DISPLAY AN INCREASED RISK OF DEVELOPING CO-OCCURRING CONDITIONS SUCH AS CONGENITAL HEART DEFECTS, AUTISM SPECTRUM DISORDERS, SEIZURE DISORDERS, AUTOIMMUNE CONDITIONS, AND ALZHEIMER’S DISEASE. DESPITE MANY RESEARCH EFFORTS, THE MECHANISMS BY WHICH T21 CAUSES THESE EFFECTS ARE YET TO BE DEFINED. THE CLINICAL PRESENTATION OF DS IS HIGHLY HETEROGENEOUS, WHICH COULD BE DRIVEN BY DIFFERENCES IN GENETIC MAKEUP, EPIGENETIC MECHANISMS, OR VARIATIONS IN THE PATHOPHYSIOLOGY OF DS REVEALED IN MULTI-OMICS SIGNATURES. FURTHERMORE, THE IMPACTS OF T21 ARE LIKELY MODULATED BY SEX, RACE/ETHNICITY, SOCIO-ECONOMIC STATUS, LIFESTYLE, AND CULTURAL BACKGROUND. THEREFORE, THERE IS A CLEAR NEED TO DEVELOP A RESEARCH INFRASTRUCTURE THAT COULD SUPPORT A WIDE RANGE OF INVESTIGATIONS BY A MULTIDISCIPLINARY TEAM OF RESEARCHERS. ACCORDINGLY, WE PROPOSE TO DEVELOP A DOWN SYNDROME BIOREPOSITORY (DS-BIOREPOSITORY) BY LEVERAGING THE INFRASTRUCTURE AND EXPERTISE DEVELOPED THROUGH WELL-ESTABLISHED COHORT STUDIES OF DS: THE HUMAN TRISOME PROJECT (HTP), THE ALZHEIMER BIOMARKERS CONSORTIUM – DOWN SYNDROME (ABC-DS), AND THE DOWN SYNDROME BIOBANK CONSORTIUM (DSBC). IN COLLABORATION WITH OTHER KEY STAKEHOLDERS IN THE DS RESEARCH COMMUNITY, WE WILL ACCOMPLISH THE FOLLOWING SPECIFIC AIMS: 1. SERVE AS THE PRIMARY BIOREPOSITORY FOR BIOSPECIMENS GENERATED FROM INCLUDE-FUNDED RESEARCH. BUILDING UPON THE INFRASTRUCTURE AND AVAILABLE BIOSPECIMENS OBTAINED BY THE HTP, ABC-DS, AND DSBC, WE WILL DEVELOP A PRIMARY BIOREPOSITORY FOR ALL DS RESEARCH FUNDED BY THE NIH INCLUDE PROJECT INCLUDING BLOOD-DERIVED BIOSPECIMENS, ORAL BIOSPECIMENS, BIOPSIES, URINE, STOOL, AMNIOTIC FLUID, CORD BLOOD, AND POST-MORTEM TISSUES, INCLUDING BRAIN TISSUE. THESE EFFORTS WILL BE INFORMED BY THE PROVEN PAN-OMICS PIPELINES OF THE HTP AND ABC-DS STUDIES AND BY DECADES OF COLLECTIVE EXPERIENCE IN BIOBANKING FOR DS RESEARCH BY ALL TEAM MEMBERS. 2. COORDINATE THE IMPLEMENTATION OF STANDARD PROCESSES, PROTOCOLS, AND PRACTICES FOR BIOSPECIMEN COLLECTION. BUILDING UPON THE COMPREHENSIVE CATALOGS OF STANDARD OPERATING PROCEDURES DEVELOPED BY THE HTP, ABC-DS, AND DSBC STUDIES, AND IN COLLABORATION WITH OTHER KEY STAKEHOLDERS IN THE COMMUNITY, WE WILL IMPLEMENT COMMON PROTOCOLS FOR BIOSPECIMEN COLLECTION AND PROCESSING ACROSS A VAST NETWORK OF RESEARCH SITES. 3. DEVELOP A WEB-BASED INTERFACE TO FACILITATE THE SEARCH OF PUBLICLY ACCESSIBLE BIOSPECIMENS. BUILDING UPON THE FIRST-EVER VIRTUAL BIOREPOSITORIES FOR DS RESEARCH DEVELOPED BY OUR TEAM MEMBERS, WE WILL DEVELOP A WEB-BASED INTERFACE TO FACILITATE THE IDENTIFICATION OF BIOSPECIMENS BASED ON SAMPLE TYPE, DEMOGRAPHIC, AND CLINICAL INFORMATION OF PARTICIPANTS, AS WELL AS EXISTING DATASETS FROM THE SAME SAMPLES. TOGETHER, THESE EFFORTS WILL ACCELERATE THE PACE OF DISCOVERIES THAT BENEFIT PEOPLE WITH DS, WHILE CREATING A HIGH- QUALITY LASTING RESOURCE FOR FUTURE GENERATIONS OF DS RESEARCHERS.

INSTITUTIONAL NATIONAL TRAINING AWARD

A PHENOMICS-FIRST RESOURCE FOR INTERPRETATION OF VARIANTS

INSIGHTS INTO IMMUNE-RELATED DISEASE BORN FROM POPULATION GENOMICS

AMERICAN INDIAN AND ALASKA NATIVE HEALTH DISPARITIES

COLORADO HEAD AND NECK CANCER SPORE - PROJECT SUMMARY, OVERALL THE MAIN GOAL OF THE COLORADO (CO) HEAD AND NECK CANCER (HNC) SPORE IS TO ADVANCE TRANSLATIONAL RESEARCH TO IMPROVE SURVIVAL AND QUALITY OF LIFE FOR HNC PATIENTS. OPTIMAL TREATMENT FOR HNC PATIENTS IS CRITICALLY IMPORTANT BECAUSE THE HEAD AND NECK ORGANS SUPPORT CRITICAL FUNCTIONS SUCH AS BREATHING, NOURISHING AND COMMUNICATING, AND THUS HNC CAN LEAD TO SIGNIFICANT MORBIDITY AND MORTALITY. THE CO HNC SPORE TAKES ADVANTAGE OF OUR EXPERTISE IN BASIC AND CLINICAL SCIENCES, AND USES UNIQUE MODEL SYSTEMS TO IDENTIFY NOVEL MOLECULAR AND CELLULAR MECHANISMS OF HNC PATHOGENESIS TARGETABLE BY THERAPEUTIC INTERVENTIONS TO TREAT ALL CANCER TYPES ARISING FROM HEAD AND NECK ANATOMIC SITES. THREE PROJECTS COVER THE TREATMENT SPECTRUM OF HEAD AND NECK SQUAMOUS CELL CARCINOMA (HNSCC) AND INCLUDE BOTH TOBACCO-RELATED AND HUMAN PAPILLOMAVIRUS (HPV)-RELATED HNSCC. PROJECT 1 STUDIES NOVEL IMMUNOTHERAPY MECHANISMS BY INHIBITING EPHB4-EFNB2 INTERACTIONS BETWEEN IMMUNE CELLS AND THE ENDOTHELIUM. IT WILL TEST IF BLOCKADE OF EPHB4-EFNB2 SIGNALING AT THE TUMOR ENDOTHELIAL BARRIER HINDERS TREGS' AND TAMS' ABILITY TO INFILTRATE AND PROMOTE CANCER SURVIVAL OR SUPPRESS TEFF FUNCTION. THE APPLICABILITY OF PRE-CLINICAL DATA TO CLINIC WILL BE ASSESSED IN SAMPLES FROM HNSCC PATIENTS TREATED WITH AN EPHB4- EFNB2 INHIBITOR DURING A WINDOW TRIAL. PROJECT 2 INVESTIGATES IF DUAL INHIBITION OF TGFSS/PD-L1 COMBINED WITH RADIATION THERAPY (RT) INDUCES IN SITU VACCINATION, REVERSES IMMUNE SUPPRESSION, AND OVERCOMES RT RESISTANCE. IT WILL TRANSLATE ITS FINDINGS WITH A TRIAL OF THE TGFSS/PD-L1 DUAL INHIBITOR M7824 COMBINED WITH RT IN LOCALLY RECURRENT AND OLIGOMETASTATIC HNSCC PATIENTS. PROJECT 3 WILL STUDY MECHANISMS OF PROTEIN ELONGATION INHIBITION IN HNSCC, IDENTIFYING KEY PROTEINS TARGETED BY THE NOVEL INHIBITOR SVC112 (A DRUG DISCOVERED IN COLORADO THAT IS NEARING CLINICAL TESTING), AND TRANSLATING OUR FINDINGS BY TESTING THE DISTRIBUTION AND PROGNOSTIC SIGNIFICANCE OF ITS TARGET (EEF2) IN PATIENT SAMPLES. IT WILL USE IMMUNE RELEVANT MODELS INCLUDING SYNGENEIC AND HUMANIZED MICE TO STUDY IMMUNE-DEPENDENT AND –INDEPENDENT MECHANISMS OF SVC112 AND STUDY IF PROTEIN ELONGATION INHIBITION IMPACTS THE TUMOR MICROENVIRONMENT AND ENHANCES RT IN HNSCC. THE DEVELOPMENTAL RESEARCH PROGRAM (DRP) IS DESIGNED TO ATTRACT CURRENT HNC RESEARCHERS AND RESEARCHERS FROM OTHER FIELDS TO CONDUCT INNOVATIVE RESEARCH IN ALL TYPES OF CANCERS ARISING FROM HEAD AND NECK TISSUES. THE CAREER ENHANCEMENT PROGRAM (CEP) IS DESIGNED TO SOLICIT JUNIOR RESEARCHERS TO DEVELOP RESEARCH PROJECTS TO TRANSITION INTO INDEPENDENT HNC RESEARCHERS. WE ENCOURAGE UNDERREPRESENTED MINORITY (URM) AND PEOPLE WITH DISABILITIES TO APPLY FOR DRP AND CEP PROJECTS. THE CO HNC SPORE ALSO INCLUDES BIOSPECIMEN/PATHOLOGY, DATA SCIENCE, AND ADMINISTRATIVE CORES. IN SUM, THE CO HNC SPORE WILL SOLIDIFY IN-DEPTH HNC TRANSLATIONAL RESEARCH AND EXPAND OUR TEAM OF DEDICATED HNC RESEARCHERS. THESE ACTIVITIES WILL IMPROVE THE CARE SPANNING THE ENTIRE SPECTRUM OF HNC TREATMENT FROM IMPROVING CURES TO DEVELOPING INNOVATIVE PALLIATION STRATEGIES FOR HNC PATIENTS.

IDIOPATHIC PULMONARY FIBROSIS, A DISEASE INITIATED BY MUCOCILIARY DYSFUNCTION

IMPACT OF MARIJUANA LEGALIZATION: COMPARISON OF TWO LONGITUDINAL TWIN COHORTS

COMPARATIVE EFFECTIVENESS RESEARCH & COCHRANE EYES AND VISION (CEV)

UC DENVER DIABETES RESEARCH CENTER

INTEGRATION, DISSEMINATION AND EVALUATION(BRIDGE) CENTER FOR THE NIH BRIDGE TO ARTIFICIAL INTELLIGENCE (BRIDGE2AI) PROGRAM - PROJECT SUMMARY: OVERALL BRIDGE CENTER THE PROMISE OF USING BIG DATA FOR PRECISION MEDICINE, DRUG DISCOVERY, AND A HOST OF OTHER CHALLENGES HAS REMAINED ELUSIVE. SOCIAL AND TECHNICAL BARRIERS HAVE LIMITED OUR ABILITY TO LEVERAGE OUR COLLECTIVE DATA ASSETS TO ADDRESS BIOMEDICAL AND BEHAVIORAL HEALTH CHALLENGES; ARTIFICIAL INTELLIGENCE (AI) SOLUTIONS PRESENT AN OPPORTUNITY TO OVERCOME THESE BARRIERS. THE NIH HAS ESTABLISHED THE BRIDGE TO ARTIFICIAL INTELLIGENCE (BRIDGE2AI, OR B2AI) PROGRAM TO CATALYZE AI SOLUTIONS TO A SET OF COMMUNITY-DEFINED “GRAND CHALLENGES.” THIS CONCERTED EFFORT WILL LAY THE GROUNDWORK TO PROMOTE THE WIDESPREAD ADOPTION OF AI AND TO ENSURE THAT IT LEADS TO TRUSTWORTHY, INCLUSIVE RESEARCH INNOVATIONS THAT HAVE A SIGNIFICANT, POSITIVE IMPACT ON HUMAN HEALTH. THE BRIDGE CENTER PROPOSAL INCLUDES ADMINISTRATIVE, TEAMING, SKILLS AND WORKFORCE DEVELOPMENT, AND STANDARDS CORES, CHOSEN TO COINCIDE WITH THE CORE TEAMS’ UNIQUE AND COMPLEMENTARY EXPERTISE IN LARGE-SCALE TEAM SCIENCE, STANDARDS DEVELOPMENT AND DISSEMINATION, INNOVATIVE TRAINING APPROACHES, AND COMMUNITY BUILDING. THE VISION FOR THE BRIDGE CENTER IS TO ENGAGE ALL PARTICIPANTS WITHIN AND BEYOND THE B2AI COMMUNITY THROUGH CAREFULLY CONSIDERED SOCIAL AND TECHNICAL MECHANISMS AND OPERATIONAL EXCELLENCE, WITH THE GOAL OF CREATING A DYNAMIC, PRODUCTIVE, AND INCLUSIVE COMMUNITY THAT BUILDS UPON EACH OTHER’S WORK IN A DEEPLY COLLABORATIVE MANNER. THE MISSION OF THE BRIDGE CENTER IS TO COMPLEMENT THE BRIDGE2AI DATA GENERATION PROJECTS (DGPS) BY SUPPORTING THE INTEGRATION, DISSEMINATION, AND EVALUATION OF BRIDGE2AI WORK PRODUCTS AND TEAMS. WE PROPOSE TO ACHIEVE THAT MISSION THROUGH THREE AIMS. AIM 1 FOCUSES ON INTEGRATING ACROSS THE BRIDGE2AI PROGRAM. SPECIFICALLY, WE WILL FOSTER GROUP IDENTITY TO CREATE OPPORTUNITIES AND INCENTIVES FOR TRANSDISCIPLINARY LEARNING; ESTABLISH HUMAN & MACHINE-UNDERSTANDABLE STANDARDS, PRACTICES, AND VOCABULARIES ACROSS B2AI; AND DEPLOY TECHNOLOGY TO PROMOTE TRANSPARENCY AND SCALABILITY ACROSS THE B2AI PROGRAM. AIM 2 CREATES AND PROMOTES OPPORTUNITIES TO EVALUATE AND IMPROVE B2AI PRODUCTS AND ACTIVITIES INCLUDING (1) EMPLOYING COMMUNITY-BASED EVALUATION WITHIN AND ACROSS DGPS, (2) DEPLOYING DATA-DRIVEN EVALUATION AND IMPROVEMENT OF B2AI PRODUCTS AND PROCESSES, AND (3) ESTABLISHING AND MAINTAINING DIVERSITY IN B2AI DATA, PEOPLE, AND TEAM STRUCTURES THROUGH A CONTINUOUS PROCESS OF EVALUATION AND REFINEMENT. AIM 3 FOCUSES ON SUSTAINABLE DISSEMINATION OF PRODUCTS, KNOWLEDGE, BEST PRACTICES AND “LESSONS LEARNED” FROM B2AI THEREBY ENSURING BROAD, LONG-LASTING DISTRIBUTION AND IMPACT. TAKEN TOGETHER, THESE AIMS WILL CREATE A BRIDGE CENTER THAT FOSTERS BROAD COMMUNITY ENGAGEMENT, INCLUSIVITY, AND TRUST TO SUCCESSFULLY INTEGRATE ACTIVITIES AND KNOWLEDGE ACROSS THE B2AI PROGRAM; DISSEMINATE PRODUCTS, BEST PRACTICES, AND SKILL DEVELOPMENT MATERIALS/ACTIVITIES; AND CONTINUALLY ASSESS AND IMPROVE ALL ASPECTS OF THE BRIDGE2AI PROGRAM WITH INPUT FROM EXTERNAL STAKEHOLDER COMMUNITIES.

ADVANCING THE SCIENCE OF PALLIATIVE CARE RESEARCH ACROSS THE LIFESPAN (ASCENT) CONSORTIUM - ASCENT: OVERALL PROJECT SUMMARY/ABSTRACT ACROSS THE LIFESPAN, PEOPLE LIVING WITH SERIOUS ILLNESS SUFFER PHYSICALLY, PSYCHOSOCIALLY AND FINANCIALLY. THE HEALTH SYSTEM TOO OFTEN FAILS TO DELIVER APPROPRIATE, EFFECTIVE CARE AND PERSONS WITH SERIOUS ILLNESS (PWSI) FREQUENTLY EXPERIENCE MISMATCHES BETWEEN THEIR GOALS FOR CARE AND THE TREATMENTS RECEIVED. PALLIATIVE CARE (PC) MEETS THE NEEDS OF PWSI AND THEIR CAREGIVERS BY FOCUSING ON ACHIEVING THE BEST POSSIBLE QUALITY OF LIFE WHILE RECEIVING LIFE-PROLONGING AND CURATIVE TREATMENTS AS IS CONGRUENT WITH PATIENT GOALS OF CARE. PC IS APPROPRIATE FROM THE POINT OF DIAGNOSIS THROUGHOUT THE TRAJECTORY OF A SERIOUS ILLNESS FOR PERSONS OF ANY AGE, WITH DIAGNOSES INCLUDING CANCER, ALZHEIMER'S DISEASE AND ALZHEIMER'S DISEASE RELATED DEMENTIAS (AD/ADRD), ADVANCED ORGAN DISEASES (INCLUDING HEART, LUNG, LIVER, KIDNEY), STROKE, NEURO-MUSCULAR DEGENERATIVE DISEASES, GENETIC DISORDERS AND RARE CONGENITAL AND METABOLIC DISORDERS, AMONG OTHERS. WHILE THERE HAVE BEEN SIGNIFICANT GAINS IN THE PAST 2 DECADES, THE EVIDENCE BASE TO GUIDE AND IMPROVE PC – AND THUS TO IMPROVE THE QUALITY OF LIFE FOR PWSI AND THEIR CAREGIVERS – REMAINS INADEQUATE. WE THUS URGENTLY NEED TO EXPAND THE PC EVIDENCE BASE AND CREATE A ROBUST FIELD CAPABLE OF CREATING THAT EVIDENCE BASE. THE ADVANCING THE SCIENCE OF PALLIATIVE CARE RESEARCH ACROSS THE LIFESPAN (ASCENT) CONSORTIUM WILL BE A NATIONAL CONSORTIUM OF EXPERTS IN PC THAT WILL ADVANCE INNOVATIVE, HIGH-QUALITY RESEARCH TO IMPROVE CARE FOR PEOPLE LIVING WITH SERIOUS ILLNESS BY PROVIDING RESOURCES AND EXPERTISE IN A COORDINATED MANNER. SPECIFICALLY, THE ASCENT CONSORTIUM WILL: 1) DEVELOP THE NATIONAL SCIENTIFIC INFRASTRUCTURE AND COMMUNITY NEEDED TO ADVANCE PC RESEARCH. THE ASCENT COMMUNITY WILL INCLUDE SCIENTISTS, HEALTHCARE SYSTEMS, COMMUNITY-BASED ORGANIZATIONS, CLINICIANS, ADVOCATES, PATIENTS AND CAREGIVERS TO INFORM RESEARCH PRIORITIES, STUDY DESIGN, AND DISSEMINATION STRATEGIES TO MAXIMIZE THE RELEVANCE AND IMPACT OF ASCENT. 2) CREATE NEW PC RESEARCH KNOWLEDGE AND RESEARCH METHODOLOGIES BY CONDUCTING DEVELOPMENTAL PROJECTS, CREATING A PC RESEARCH METHODOLOGY AND CAREER DEVELOPMENT CURRICULUM, AND SUPPORTING THE WORK OF PC SCIENTISTS VIA FUNDING AND PROVISION OF RESOURCES AND EXPERT CONSULTATION. 3) FOSTER CAREER DEVELOPMENT AND IMPACT OF THE PC FIELD BY SUPPORTING CAREER DEVELOPMENT AND PILOT AWARDS, PROVIDING ACCESS TO METHODOLOGIC CONSULTATIONS, AND MENTORING SCIENTISTS. 4) DISSEMINATE PC RESEARCH FINDINGS AND FACILITATE SUBSEQUENT ADOPTION AND IMPLEMENTATION, EMPLOYING A MULTI-PRONGED APPROACH TO DISSEMINATION. THROUGH THESE 4 SPECIFIC AIMS, THE ASCENT CONSORTIUM WILL TRANSFORM THE FIELD OF PC RESEARCH, GENERATING NEW KNOWLEDGE AND METHODS, DEVELOPING AND EXPANDING THE PALLIATIVE CARE FIELD, AND FACILITATING IMPLEMENTATION TO ENHANCE THE EXPERIENCE OF PWSI AND THEIR CAREGIVERS ACROSS THE LIFESPAN.

CENTER FOR AMERICAN INDIAN AND ALASKA NATIVE DIABETES TRANSLATIONAL RESEARCH

A CLEARINGHOUSE ON NATURAL HAZARDS APPLICATIONS

CU BOULDER CENTER FOR CRYO-ET (CCET)

MYOSIN GENE DIVERSITY AND FUNCTION

DATA FUSION: A SUSTAINABLE, SCALABLE, OPEN SOURCE REGISTRY ADVANCING PVD RESEARCH

TAS::97 0400::TAS "WIRING QUANTUM NETWORKS WITH MECHANICAL TRANSDUCERS, DATED 16 DEC 2013" (THE GRANTEE'S TECHNICAL PROPOSAL);

LUNG VASCULAR DISEASE IN INFANTS AND CHILDREN: MECHANISMS AND TREATMENT

NATURAL HISTORY OF PRE-DIABETIC AUTOIMMUNITY (DAISY)

IBSC DETERMINANTS OF EXECUTIVE FUNCTION AND DYSFUNCTION

ROLE OF MUCIN IN LUNG HOMEOSTASIS AND PATHOPHYSIOLOGY

CLINICAL RESOURCE FOR LUNG AND ALCOHOL INVESTIGATIONS

TEACHER QUALITY PARTNERSHIPS GRANTS

LOOK AHEAD: ACTION FOR HEALTH IN DIABETES

UNIVERSITY OF COLORADO CENTER FOR ASTROBIOLOGY

PALLIATIVE CARE RESEARCH COOPERATIVE GROUP (PCRC): REFINEMENT AND EXPANSION

CLIMATE CHANGE CLEAN PRODUCTION

ROCKY MOUNTAIN CANNABIS RESEARCH CENTER - PROJECT SUMMARY/ABSTRACT ROCKY MOUNTAIN CANNABIS RESEARCH CENTER (RM-CRC) THE UNITED STATES HAS RECENTLY EXPERIENCED ENORMOUS CHANGES IN THE LEGAL STATUS AND PUBLIC ACCEPTANCE OF CANNABIS. RECREATIONAL AND MEDICAL CANNABIS PRODUCTS THAT CONTAIN VARYING AMOUNTS OF TETRAHYDROCANNABINOL (THC) AND CANNABIDIOL (CBD) ARE NOW WIDELY AVAILABLE THROUGHOUT NORTH AMERICA. DESPITE THESE CHANGES, RESEARCH ON THE EFFECTS OF THC AND CBD HAS BEEN LACKING. THE CENTRAL GOALS OF THIS RESEARCH CENTER OF EXCELLENCE APPLICATION ARE TO EVALUATE, IN THREE RESEARCH PROJECTS THAT SPAN EMERGING, MIDDLE-AGED, AND OLDER ADULTS, HOW CBD AFFECTS THE USE OF AND SUBJECTIVE RESPONSE TO THC, AND WHETHER THESE EFFECTS ARE MEDIATED BY THE ENDOCANNABINOID SYSTEM (ECS) AND ASSOCIATED LIPIDS. TO THAT END, THE THREE RESEARCH PROJECTS WITHIN THE RM-CRC UTILIZE RESEARCH STRATEGIES THAT CAPITALIZE ON THREE KEY INNOVATIONS. FIRST, THE PROJECTS WILL EMPLOY MOBILE PHARMACOLOGY LABORATORIES TO COLLECT BIOLOGICAL SAMPLES AND ASSESS THE ACUTE EFFECTS OF THC AND CBD ON KEY NEUROCOGNITIVE AND BEHAVIORAL OUTCOMES, ENDOCANNABINOIDS, AND OTHER LIPIDS THAT INTERACT WITH THE ECS. SECOND, UNDER THE AUSPICES OF AN FDA IND WE HOLD FOR HEMP-DERIVED CBD, PROJECTS WILL RANDOMLY ASSIGN PARTICIPANTS TO CBD OR PLACEBO AND WILL PARAMETRICALLY MANIPULATE EITHER THE DOSE OF CBD OR WHETHER THE CBD PRODUCT CONTAINS THC, TO DETERMINE HOW HEMP-DERIVED CBD PRODUCTS MAY IMPACT THE EFFECTS OF THC. FINALLY, THE PROJECTS RELY ON NEWLY DESIGNED ASSAYS WITHIN OUR CANNABIS RESEARCH ANALYTICS CORE (CRAC) TO MEASURE CANNABINOIDS, METABOLITES, TERPENES, ENDOCANNABINOIDS, AND OTHER LIPID MEDIATORS IN BLOOD SAMPLES. THE DATA HARMONIZATION AND ANALYSIS CORE (DHAC) WILL DEPLOY A SINGLE-SOLUTION SYSTEM TO SUPPORT DATA COLLECTION, HARMONIZATION ACROSS PROJECTS, AND SHARING OF THE DATA WITH THE LARGER SCIENTIFIC COMMUNITY DIRECTLY AND VIA NIH APPROVED REPOSITORIES. THE DHAC WILL ALSO HARMONIZE PREVIOUSLY COLLECTED DATA (FROM 7 R01S, N=1359) AND CONDUCT ADVANCED MACHINE LEARNING ANALYSES OF THE RELATIONSHIPS BETWEEN THC AND CBD BLOOD LEVELS, ENDOCANNABINOIDS AND OTHER LIPID MEDIATORS, AND BEHAVIORAL DATA. THE RESULTS WILL INFORM CENTER-WIDE ANALYSES OF THE HARMONIZED P50 PROJECT DATA. THUS, THE CRAC AND DHAC PROVIDE THE RM-CRC WITH SIGNIFICANT ADDED VALUE THAT WILL ALLOW THE CENTER TO GENERATE SIGNIFICANT NEW KNOWLEDGE WITH RESPECT TO HOW CHANGES IN THE ECS AND RELATED LIPIDS MEDIATE THE EFFECTS OF THC AND CBD ACROSS THE LIFESPAN. THE RM-CRC IS EXPECTED TO BE A SIGNIFICANT RESOURCE TO THE FIELD MORE BROADLY BY PROVIDING OTHER SCIENTISTS ACCESS TO DATA REGARDING CBD EFFECTS ON PSYCHIATRIC AND HEALTH OUTCOMES, CANNABINOID, METABOLITE, AND TERPENE BLOOD LEVELS, AND 100+ ENDOCANNABINOIDS AND RELATED LIPID MEDIATORS IN APPROXIMATELY 2000 PARTICIPANTS.

HEALTH CENTER CLUSTER

TEAMUP: TANDEMS FOR EFFICIENT AND ADVANCED MODULES USING ULTRASTABLE PEROVSKITES A. PROJECT OBJECTIVES WE PROPOSE TO ESTABLISH TEAMUP, A DIVERSE PV CONSORTIUM, WITH MEMBERS STRATEGICALLY CHOSEN TO TARGET >28%-EFFICIENT PEROVSKITE/SILICON MULTIJUNCTION MODULES WITH STABLE OPERATION IN FIELD CONDITIONS. THE TEAM WE HAVE CHOSEN HAS A PROVEN RECORD OF PIONEERING RESEARCH ON PEROVSKITE TANDEM SOLAR CELLS.

SCALABLE ARCHITECTURE FOR FEDERATED THERAPEUTIC INQUIRIES NETWORK (SAFTINET)

SPECIAL PROJECTS (CNS): NATIONAL CENTER FOR WOMEN AND INFORMATION TECHNOLOGY (NCWIT): MOVING TOWARD SUSTAINABILITY FOR WOMEN IN COMPUTING

TAS::57 3600::TAS '(MURI-2017) INTEGRATED MEASUREMENT AND MODELING CHARACTERIZATION OF STRATOSPHERIC TURBULENCE'

A MULTICENTER RANDOMIZED CONTROLLED TRIAL OF SURVEILLANCE VERSUS. ENDOSCOPIC THERAPY FOR BARRETTS ESOPHAGUS WITH LOW-GRADE DYSPLASIA: THE SURVENT TRIAL - PROJECT SUMMARY/ABSTRACT BARRETT'S ESOPHAGUS (BE), A METAPLASTIC CHANGE OF THE ESOPHAGEAL LINING ASSOCIATED WITH CHRONIC GASTROESOPHAGEAL REFLUX DISEASE, IS THE ONLY KNOWN PRECURSOR TO ESOPHAGEAL ADENOCARCINOMA (EAC). EAC IS ONE OF THE MOST RAPIDLY INCREASING CANCERS IN THE UNITED STATES, FREQUENTLY PRESENTING AT AN ADVANCED STAGE AND ASSOCIATED WITH A DISMAL 5-YEAR SURVIVAL RATE. ENDOSCOPIC ERADICATION THERAPY (EET) IS THE STANDARD OF CARE FOR PATIENTS WITH BE AND HIGH-GRADE DYSPLASIA (HGD) OR MUCOSAL EAC. HOWEVER, A CENTRAL UNRESOLVED ISSUE IS WHETHER BE PATIENTS WITH LOW-GRADE DYSPLASIA (LGD) BENEFIT FROM EET. THE DIAGNOSIS OF LGD IS FAR MORE COMMON THAN HGD AND IS ASSOCIATED WITH A LOWER RISK OF EAC, SO IT IS UNCLEAR WHETHER THE COSTS AND COMPLICATIONS OF EET ARE JUSTIFIED IN THIS GROUP OF PATIENTS OR WHETHER THEY SHOULD SIMPLY CONTINUE WITH PERIODIC SURVEILLANCE ENDOSCOPY. THE PRESENCE OF CLINICAL EQUIPOISE AND THE IMPORTANCE OF THIS QUESTION INDICATES THAT A TRIAL OF ENDOSCOPIC SURVEILLANCE VERSUS EET IN THIS PATIENT POPULATION IS AN URGENT, UNMET GAP IN OUR CURRENT KNOWLEDGE REGARDING TREATMENT OF THIS COMMON CONDITION. WE ARE UNIQUELY POSITIONED TO ADDRESS THIS SIGNIFICANT GAP IN KNOWLEDGE AS WE HAVE ASSEMBLED A MULTIDISCIPLINARY TEAM WITH THE REQUISITE EXPERTISE IN THE CONDUCT OF CLINICAL TRIALS AND BIOMARKER RESEARCH TO ENSURE SUCCESSFUL DESIGN AND HIGH-QUALITY EXECUTION OF THE SURVENT TRIAL (SURVEILLANCE VERSUS ENDOSCOPIC THERAPY FOR BE WITH LGD). THIS MULTICENTER RANDOMIZED CONTROLLED TRIAL (N=530) WILL COMPARE ENDOSCOPIC SURVEILLANCE AND EET FOR THE MANAGEMENT OF LGD USING UNIFORM INCLUSION CRITERIA, DESIGN AND ENDPOINTS. THIS TRIAL WILL ALSO INCLUDE AN OBSERVATIONAL COHORT ARM FOR THOSE WHO DECLINE RANDOMIZATION BUT ARE OTHERWISE ELIGIBLE (UP TO 150 SUBJECTS). FOLLOWING OUR ACHIEVEMENTS DURING THE U34 GRANT PERIOD, WE PROPOSE THE FOLLOWING AIMS FOR THE U01: SPECIFIC AIM #1 WILL COMPARE THE TWO APPROACHES USING THE PRIMARY ENDPOINT OF NEOPLASTIC PROGRESSION RATE (PROGRESSION TO HGD OR MUCOSAL OR INVASIVE EAC). SPECIFIC AIM #2 WILL COMPARE PATIENT-CENTERED OUTCOMES SUCH AS HEALTH-RELATED QUALITY OF LIFE BETWEEN THE TWO TREATMENT GROUPS. SPECIFIC AIM #3 WILL DETERMINE THE UTILITY OF MOLECULAR (TISSUECYPHER AND P53 IMMUNOHISTOCHEMISTRY) AND IMAGING (WIDE-AREA TRANSEPITHELIAL SAMPLING – WATS) BIOMARKERS TO IMPROVE RISK-STRATIFICATION IN BE WITH LGD PATIENTS UNDERGOING SURVEILLANCE AND EET. BIOLOGICAL SAMPLES WILL ALSO BE OBTAINED AT PRE-SPECIFIED TIME POINTS TO ESTABLISH A BIOREPOSITORY FOR FUTURE TRANSLATIONAL RESEARCH INITIATIVES. THE RELEVANCE OF THIS WORK TO THE PUBLIC HEALTH IS HIGH. BE IS A COMMON CONDITION, AFFECTING 2-3% OF ADULT US POPULATION AND LGD IS SEEN IN UP TO 40% OF BE PATIENTS. THIS IS A PRECURSOR FOR EAC AND MILLIONS OF DOLLARS ARE SPENT YEARLY ON THE MANAGEMENT OF BE AND EAC PATIENTS. THE IMPACT OF OUR INNOVATIVE STUDY WILL INCLUDE IDENTIFYING THE BEST PATIENT-CENTERED TREATMENT APPROACH FOR BE PATIENTS WITH LGD, WHICH WILL INFORM THE CARE OF THOUSANDS OF PATIENTS ANNUALLY.

BERYLLIUM: EXPOSURE, IMMUNE AND GENETIC MECHANISMS

BUILDING INTERDISCIPLINARY RESEARCH CAREERS IN WOMEN'S HEALTH

AI INSTITUTE FOR STUDENT AI TEAMING -THE RENEWAL OF THE INSTITUTE FOR STUDENT-AI TEAMING WILL CONTINUE TO DIRECTLY ADDRESS THE URGENT NATIONAL NEED TO DEVELOP A WORLD-LEADING, NEXT-GENERATION ARTIFICIAL INTELLIGENCE (AI) WORKFORCE. THE INSTITUTE WILL PURSUE A TRANSFORMATIVE NEW VISION FOR 21ST CENTURY K-12 CLASSROOMS THAT USES AI TO PROMOTE STUDENT SUCCESS IN STEM--WHERE ALL STUDENTS EXPERIENCE AUTHENTIC LEARNING BY CO-CONSTRUCTING KNOWLEDGE, MAKING DISCOVERIES THROUGH INQUIRY, AND DEVELOPING THEIR INTERESTS. THIS WORK REFRAMES THE ROLE OF AI IN EDUCATION, PIONEERING A FUTURE WHERE AI SERVES AS A SOCIAL, COLLABORATIVE PARTNER THAT HELPS STUDENTS AND TEACHERS MAKE LEARNING MORE EFFECTIVE AND ENGAGING. THE INSTITUTE WILL PUSH THE CAPABILITIES OF AI TO SUPPORT SMALL GROUPS WITH KNOWLEDGE SHARING AND UPTAKE, COLLABORATIVELY SOLVING COMPLEX PROBLEMS, AND WORKING THROUGH UNCERTAINTY AND DIFFERENCES IN IDEAS TO ENGENDER MENTAL LEAPS DURING STEM LEARNING. THE BROAD RESEARCH AGENDA WILL FOCUS ON DEVELOPING, TESTING, AND SCALING AI PARTNERS AND THEIR INTEGRATION IN INNOVATIVE STEM CURRICULA SUPPORTING AI EDUCATION THROUGH HANDS-ON STUDENT-CENTERED INVESTIGATIONS. RESEARCH WILL BE SITUATED IN AUTHENTIC SCHOOL CONTEXTS AND DEVELOPED IN CLOSE PARTNERSHIPS WITH STUDENTS, TEACHERS, AND SCHOOL DISTRICTS TO EXAMINE THE IMPACTS OF AI-ENHANCED PEDAGOGIES ON LEARNERS' COLLABORATION SKILLS AS WELL AS THEIR STEM KNOWLEDGE AND CAPABILITIES. A DEDICATED NEXUS HUB WILL WORK WITH MORE THAN 25 ORGANIZATIONS TO AMPLIFY THE INSTITUTE'S TRANSLATIONAL IMPACT--CONNECTING RESEARCH, EDUCATION SYSTEMS, AND INDUSTRY TO ACCELERATE INNOVATION AND WORKFORCE READINESS. THE INSTITUTE WILL ADVANCE THE NEW SCIENCE OF STUDENT-AI TEAMING THROUGH FOUNDATIONAL AND USE-INSPIRED RESEARCH CONTRIBUTIONS. FOUNDATIONAL ADVANCES IN MULTIMODAL, MULTIPARTY, SITUATED AWARENESS IN AUTHENTIC CLASSROOM ENVIRONMENTS WILL YIELD AI MODELS THAT CAN AUTONOMOUSLY MONITOR UNFOLDING COLLABORATIVE DISCOURSE AT MULTIPLE LEVELS - UNDERSTANDING THE CONTENT, THE CONVERSATIONAL DYNAMICS, GESTURES, AND OTHER COMMUNICATIVE SIGNALS - AND LEARN OPTIMAL AI CONTROL STRATEGIES GROUNDED IN THE LEARNING SCIENCES. NEW FRAMEWORKS OF TRUSTWORTHY AI IN EDUCATION WILL SUPPORT COLLABORATIVE LEARNING INVOLVING COMPLEX KNOWLEDGE SHARING AND NEGOTIATIONS AMONG LEARNERS, TEACHERS, AND AI PARTNERS. THESE FRAMEWORKS WILL EXTEND BEYOND EXISTING NOTIONS OF PRIVACY, SECURITY, AND TRANSPARENCY TO ADDRESS RELATIONAL PRIVACY, LONGITUDINAL TRUST CALIBRATION, AND HUMANS-IN-THE-LOOP, EMPOWERING STUDENTS WITH INFORMED AGENCY OVER THEIR CLASSROOM AI. CO-DESIGN WITH EDUCATORS AND YOUTH WILL PRODUCE A SEMESTER-LONG SEQUENCE OF PROBLEM-BASED UNITS DESIGNED TO DEVELOP STUDENTS' AI LITERACY, ALONG WITH CURRICULUM-LINKED PROFESSIONAL LEARNING THAT PREPARES EDUCATORS TO IMPLEMENT AI-ENABLED CURRICULA WITH INTEGRITY. CASE STUDIES ON SCHOOL-WIDE IMPLEMENTATIONS WILL DEVELOP DEEPER UNDERSTANDING OF SCHOOL PRACTICES AND CONDITIONS THAT SHAPE UPTAKE AND EFFECTIVE IMPLEMENTATION OF AI-ENABLED CURRICULA. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE PLANNED FOR THIS AWARD.

NNA-CO: A COMMUNITY OFFICE FOR COORDINATION, PARTNERSHIP, AND CAPACITY-BUILDING TO SUPPORT CONVERGENCE RESEARCH IN THE RAPIDLY CHANGING ARCTIC

STRUCTURAL STUDIES OF EUKARYOTIC TRANSCRIPTION

ROCKY MOUNTAIN PREVENTION RESEARCH CENTER

TECHNOLOGY DEVELOPMENT FOR A MOLBIO KNOWLEDGE-BASE

BAA 12-63

TRAINING PROGRAM IN IMMUNOLOGY

DESIGN AND ENGINEERING OF SYNTHETIC CONTROL ARCHITECTURES

BENAROYA RESEARCH INSTITUTE/UCDHSC AUTOIMMUNE COOPERATIVE STUDY GROUP

MECHANISMS REGULATING LUNG INJURY AND EARLY LUNG FIBROSIS - ABSTRACT THE OVERALL GOAL OF THIS PROGRAM IS TO UNDERSTAND THE ROLE OF MUC5B IN ESTABLISHING A VULNERABLE LUNG AND THE TRANSITION OF A VULNERABLE LUNG TO A LUNG CHARACTERIZED BY PERSISTENT INJURY OF BRONCHOALVEOLAR EPITHELIA AND ACTIVATION OF LUNG FIBROBLASTS. WHILE OUR FINDINGS HAVE IDENTIFIED A NOVEL MOLECULE (MUC5B) AND TARGET (BRONCHOALVEOLAR EPITHELIA) FOR IPF, ONLY ˜5% OF INDIVIDUALS WITH THIS GENETIC VARIANT DEVELOP USUAL INTERSTITIAL PNEUMONIA (UIP) ON HRCT SCAN, SUGGESTING THE NEED FOR ANOTHER INSULT (A ‘SECOND HIT’) TO INITIATE AND INTENSIFY THE FIBROPROLIFERATIVE PROCESS. BASED ON OUR PRELIMINARY FINDINGS, WE POSTULATE THAT WHILE OVEREXPRESSION OF MUC5B PLACES INDIVIDUALS AT RISK OF DEVELOPING IPF BY CAUSING PERSISTENT HOMEOSTATIC ER STRESS OF BRONCHIOLAR EPITHELIA, FIBROBLAST RECRUITMENT AND PRO-FIBROTIC PROGRAMMING REQUIRES A SECOND HIT TO THE BRONCHIOLAR EPITHELIA RESULTING IN DETRIMENTAL ER STRESS AND RECRUITMENT AND ACTIVATION OF FIBROBLASTS. OUR PROGRAM INCLUDES 3 SCIENTIFIC PROJECTS AND 4 CORES, AND OUR UNIFYING SCIENTIFIC THEMES INCLUDE: 1) IPF IS INITIATED BY ENHANCED EXPRESSION OF MUC5B (FIRST HIT) THAT ESTABLISH A VULNERABLE LUNG CHARACTERIZED BY PERSISTENT HOMEOSTATIC ER STRESS (WITHOUT SUBSTANTIAL UPR OR APOPTOSIS); 2) SECONDARY INJURY TO THE BRONCHOALVEOLAR EPITHELIA RESULTS IN TRANSITION OF A VULNERABLE LUNG TO A LUNG CHARACTERIZED BY DETRIMENTAL ER STRESS (INVOLVING SUBSTANTIAL UPR AND APOPTOSIS) AND THE DEVELOPMENT OF MICROSCOPIC BRONCHIOLAR-CENTRIC FIBROPROLIFERATION; AND 3) UNDERSTANDING ETIOLOGIC AND INITIAL BIOLOGICAL RESPONSES IN DISTAL AIRWAY EPITHELIA AND AEC2 CELLS, AND THE INTERACTION OF BRONCHOALVEOLAR EPITHELIA WITH LUNG FIBROBLASTS WILL CREATE OPPORTUNITIES FOR DISEASE PREVENTION AND EARLY INTERVENTION. THE OVERARCHING HYPOTHESIS OF OUR PROGRAM IS THAT THE DEVELOPMENT OF IPF REQUIRES TWO HITS, MUC5B OVEREXPRESSION IN BRONCHIOLAR EPITHELIA THAT INDUCES A HOMEOSTATIC, PRIMING RESPONSE AND SUBSEQUENT INJURY OF THE BRONCHIOLAR EPITHELIA THAT RESULTS IN DETRIMENTAL ER STRESS, ABERRANT EPITHELIA, AND FIBROBLAST ACTIVATION. PROJECT 1 WILL DEFINITIVELY ADDRESS THE DRIVERS OF MUC5B OVEREXPRESSION, PROJECT 2 WILL IDENTIFY THE DETERMINANTS OF EPITHELIAL INJURY AND DETRIMENTAL ER STRESS, AND PROJECT 3 WILL INVESTIGATE THE MOLECULAR INTERFACE BETWEEN MUC5B-INDUCED EPITHELIAL INJURY AND FIBROBLAST ACTIVATION. AT THE COMPLETION OF THIS HIGHLY INTEGRATED PROGRAM, WE WILL HAVE: 1) ESTABLISHED THE BASIC MOLECULAR MECHANISMS THAT REGULATE MUC5B-INDUCED INJURY/REPAIR PROCESS IN FIBROPROLIFERATION; 2) DEFINED MECHANISMS THAT WILL CREATE A ROADMAP FOR PRIMARY AND SECONDARY INTERVENTION IN IPF; AND 3) PROVIDED A RATIONALE AND TARGETS FOR EARLY INTERVENTION IN A DISEASE THAT REMAINS A SIGNIFICANT PUBLIC HEALTH PROBLEM AND MAY INCREASE POST-COVID.

TARGETING ANDROGEN RECEPTOR IN BREAST CANCER: ENZALUTAMIDE AS A NOVEL BREAST CANCER THERAPEUTIC

STRESSOR CONTROLLABILITY: THE ROLE OF THE MPFC IN PRODUCING RESILIENCY

UNIVERSITY OF COLORADO AGING TRAINING GRANT

THE TEDDY STUDY - COLORADO CLINICAL CENTER

SPECIAL PROJECTS (CNS): NATIONAL CENTER FOR WOMEN AND INFORMATION TECHNOLOGY

COMPLEX ODOR RECOGNITION BY THE MAIN OLFACTORY BULB

TAS::57 3600::TAS "(MURI-15) HARNESSING STRONG-FIELD MID-INFRARED (IR) LASERS: DESIGNER BEAMS OF RELATIVISTIC PARTICLES AND THZ-TO-X-RAY LIGHT"

PHASE II TRIAL OF GM-CSF/SARGRAMOSTIM IN ALZHEIMER'S DISEASE - PROJECT ABSTRACT ALZHEIMER’S DISEASE (AD) TREATMENTS DESIGNED TO TARGET THE AMYLOID-BETA PEPTIDE HAVE SHOWN ENCOURAGING RESULTS IN TRANSGENIC ANIMAL MODELS BUT LESS ENCOURAGING RESULTS IN HUMAN TRIALS, WHICH HAVE ALSO BEEN PLAGUED WITH SERIOUS ADVERSE EVENTS (SAES), INCLUDING AMYLOID-RELATED IMAGING ABNORMALITIES (ARIAS). OUR PROPOSED INNOVATIVE THERAPEUTIC APPROACH IS BASED ON EPIDEMIOLOGICAL EVIDENCE THAT PATIENTS WITH THE INFLAMMATORY DISEASE RHEUMATOID ARTHRITIS (RA) HAVE A REDUCED RISK OF DEVELOPING AD, UNRELATED TO THEIR USE OF NON-STEROIDAL ANTI-INFLAMMATORY DRUGS (NSAIDS). WE IDENTIFIED THE INNATE IMMUNE SYSTEM STIMULANT GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR (GM-CSF) AS A HEMATOPOIETIC FACTOR UPREGULATED IN RA, WHICH WE FOUND REDUCED BRAIN AMYLOIDOSIS AND REVERSED COGNITIVE IMPAIRMENT IN TRANSGENIC AD MICE. OTHER STUDIES HAVE SHOWN GM-CSF TO BE NEUROPROTECTIVE, ANTI-APOPTOTIC, AND NEUROGENIC IN SEVERAL MODELS OF NEUROLOGICAL DISEASES AND INJURIES. WE ALSO FOUND THAT RECOMBINANT HUMAN GM-CSF(SARGRAMOSTIM/LEUKINE) TREATMENT IS ASSOCIATED WITH COGNITIVE IMPROVEMENTS IN LEUKEMIA PATIENTS AFTER BONE MARROW CHEMO-ABLATION AND HEMATOPOIETIC CELL TRANSPLANT THERAPY. NOTABLY, SARGRAMOSTIM IS AN FDA-APPROVED DRUG FOR INCREASING THE PRODUCTION AND DIFFERENTIATION OF WHITE BLOOD CELLS WITH AN EXCELLENT SAFETY RECORD OVER 30 YEARS. MOST IMPORTANTLY, WE RECENTLY COMPLETED A PHASE I/II SAFETY AND EFFICACY TRIAL (NCT01409915) IN WHICH MILD-TO-MODERATE AD PARTICIPANTS WERE TREATED WITH SARGRAMOSTIM (250 MCG/M2/DAY SC) OR PLACEBO FIVE DAYS/WEEK FOR THREE WEEKS (20:20 PARTICIPANTS PER GROUP) WITH NEUROLOGICAL, NEUROPSYCHOLOGICAL, NEUROIMAGING, AND BLOOD BIOMARKER ASSESSMENTS. SARGRAMOSTIM TREATMENT WAS SAFE (PRIMARY ENDPOINT) WITH NO DRUG-RELATED SAES AND NO ARIAS. FURTHERMORE, THE MINI-MENTAL STATE EXAM (MMSE) SHOWED COGNITIVE IMPROVEMENT IN THE SARGRAMOSTIM GROUP AT THE END OF TREATMENT (EOT) COMPARED TO BASELINE (P=0.0074) AND IN THE SARGRAMOSTIM GROUP COMPARED TO THE PLACEBO GROUP AT THE EOT (P=0.037) AND AT 45 DAYS AFTER THE EOT (P=0.0281). OTHER ASSESSMENTS SHOWED NO TREATMENT BENEFITS, BUT THERE WAS A TREND NEGATIVE CORRELATION BETWEEN CHANGES IN MMSE VERSUS AMYLOID-PET. WE NOW PROPOSE TO CARRY OUT A RANDOMIZED, DOUBLE- BLIND, PLACEBO-CONTROLLED TRIAL IN 42 MILD-TO-MODERATE AD PARTICIPANTS, 28 OF WHOM WILL RECEIVE SARGRAMOSTIM (250 MCG/M2/DAY SC) AND 14 OF WHOM WILL RECEIVE PLACEBO, FIVE DAYS/WEEK FOR 24 WEEKS WITH A 45-DAY FOLLOW-UP VISIT. WE HAVE RECEIVED BOTH AN IND EXEMPTION (134291) AND IRB APPROVAL (17-0215) BUT WILL SUBMIT IMPROVED VERSIONS IN THE COMING MONTHS. OUR SPECIFIC AIMS ARE: 1) ASSESS THE LONG-TERM SAFETY AND TOLERABILITY OF SARGRAMOSTIM IN MILD-TO-MODERATE AD PARTICIPANTS (PRIMARY ENDPOINT). 2) ASSESS THE EFFECTS OF SARGRAMOSTIM TREATMENT ON COGNITION AND ACTIVITIES OF DAILY LIVING IN MILD-TO-MODERATE AD PARTICIPANTS (SECONDARY AND EXPLORATORY ENDPOINTS). 3) ASSESS CHANGES IN BIOMARKERS ASSOCIATED WITH SARGRAMOSTIM TREATMENT IN MILD-TO- MODERATE AD PARTICIPANTS (EXPLORATORY ENDPOINTS).

THE MICROBIOME AND RESPONSIVENESS TO STRESS: COUNTERMEASURE STRATEGIES FOR IMPROVING RESILIENCE TO SLEEP AND CIRCADIAN DISRUPTION

SOFT MATERIALS RESEARCH CENTER

FUNCTIONAL DEVELOPMENT OF THE MAMMARY GLAND

EXPERIMENTAL RELATIVISTIC HEAVY ION PHYSICS AT THE UNIVERSITY OF COLORADO AT BOULDER

AUTOANTIGENS FOR DIABETOGENIC CD4 T CELLS

ROCKY MOUNTAIN NEUROLOGICAL DISORDERS CORE CENTER

EPIDEMIOLOGY AND OUTCOMES OF COMBAT-RELEVANT PROLONGED TRAUMA CARE: A PROSPECTIVE MULTICENTER PREHOSPITAL STUDY IN SOUTH AFRICA

AMERICAN INDIAN AND ALASKA NATIVE HEALTH DISPARITIES

"(MURI-FY07) NEUTRAL ATMOSPHERE DENSITY INTERDICIPLINARY RESEARCH (NADIR)"

PROFESSIONAL RESEARCH EXPERIENCE PROGRAM (PREP) - GRADUATE LEVEL.

COLORADO AIDS CLINICAL TRIALS UNIT

REPROGRAMMING OF MATURE SMOOTH MUSCLE CELLS TO VASCULAR PROGENITOR CELLS

MECHANISMS OF MAST CELL DIRECTED CARBON NANOTUBE TOXICITY

LTER: ECOSYSTEM RESPONSE TO AMPLIFIED LANDSCAPE CONNECTIVITY IN THE MCMURDO DRY VALLEYS, ANTARCTICA

OBJECTIVES: THE DYNAMICS ATMOSPHERE GLOBAL-CONNECTION (DYNAGLO) MISSION WILL BE THE FIRST OF ITS KIND PROVIDING THE COMMUNITY WITH GLOBAL THERMOSPHERE GW MEASUREMENTS AND THEIR CHARACTERISTICS TO BE CORRELATED WITH KNOWN GW SOURCES (TERRESTRIAL AND

MCH RESEARCH NETWORK PROGRAMS

EXPLORING THE FUEL-MEDIATED PROGRAMMING OF NEONATAL GROWTH

PFAS EXPOSURE AND HEALTH EFFECTS IN EL PASO COUNTY, COLORADO

PHOTOSWITCHABLE BIOSTASIS

REPAIR DE-FOA-0002289 UNIVERSITY OF COLORADO BOULDER - NEW CONDITIONAL AWARD CONTROL NUMBER: 2289-1505 PROJECT TITLE: TESTING AND ANALYSIS OF PIPELINE ENCAPSULATION TECHNOLOGIES

ROCKY MOUNTAIN PREVENTION RESEARCH CENTER

RYAN WHITE TITLE IV WOMEN, INFANTS, CHILDREN, YOUTH AND AFFECTED FAMILY MEMBERS AIDS HEALTHCARE

VITGENE INTERNATIONAL CONSORTIUM TO IDENTIFY SUSCEPTIBILITY GENES FOR GENERALIZED

THE PHYSICAL SCIENCES OBSERVATION AND PREDICTION RESEARCH IN SUPPORT OF THE BIPARTISAN INFRASTRUCTURE LAW (BIL) WILL SUPPORT RESEARCH THAT FULFILLS NOAA'S VISION OF HEALTHY ECOSYSTEMS, COMMUNITIES, AND ECONOMIES THAT ARE RESILIENT IN THE FACE OF CHANGE. AS A COLLABORATING PARTNER WITH NOAA'S PHYSICAL SCIENCES LABORATORY (PSL), CIESRDS WILL EMPLOY WORLD-CLASS RESEARCHERS TO CONDUCT SCIENCE IN SERVICE TO SOCIETY IN SUPPORT OF THE EXPLORATION OF UPDATED APPROACHES TO EXTREME PRECIPITATION ESTIMATION FOR INFRASTRUCTURE HAZARD RISK PLANNING; NEXT-GENERATION OF NOAA WATER MODELING; SUBSEASONAL TO ANNUAL INTEGRATED WATER CAPABILITIES; WILDLAND FIRE POTENTIAL RESEARCH TO INFORM EXTENDED RANGE RESOURCE PLANNING; FIRE-WEATHER BOUNDARY LAYER RESEARCH; AND FIRE-WEATHER OBSERVING SYSTEMS DEVELOPMENT. THE CIESRDS RESEARCH WILL DIRECTLY SUPPORT THE PSL VISION OF AN INFORMED SOCIETY THAT USES SCIENCE-BASED ENVIRONMENTAL INTELLIGENCE TO EFFECTIVELY ANTICIPATE AND RESPOND TO THE CHALLENGES OF TOO MUCH

DEVELOPMENTAL PSYCHOPATHOLOGY, PSYCHOBIOLOGY, & BEHAVIOR

LTER: LONG-TERM RESEARCH ON THE DYNAMICS OF HIGH-ELEVATION ECOSYSTEMS -- A FRAMEWORK FOR UNDERSTANDING ECOLOGICAL RESPONSIVENESS TO CLIMATE CHANGE

ACHIEVING A 10,000 GPU PERMEANCE FOR POST-COMBUSTION CARBON CAPTURES WITH GELLED IONIC LIQUID-BASED MEMBRANES

LEADERSHIP EDUCATION IN NEURODEVELOPMENTAL AND RELATED DISORDERS TRAINING PROGRAM

RYAN WHITE TITLE IV WOMEN, INFANTS, CHILDREN, YOUTH AND AFFECTED FAMILY MEMBERS AIDS HEALTHCARE

IFNALPHABETA-DEPENDENT AND-INDEPENDENT TLR/CD40 SYNERGY

REGULATION OF PANCREATIC ISLET CELL FATE

MULTIFUNCTION PROSTHESIS CONTROL USING IMPLANTED SENSORS

INFLUENCE OF PRENATAL AND EARLY CHILDHOOD HOME-VISITING BY NURSES ON DEVELOPMENT OF CHRONIC DISEASE: 29-YEAR FOLLOW-UP OF A RANDOMIZED CLINICAL TRIAL

SIGH VENTILATION TO REDUCE THE INCIDENCE AND/OR THE SEVERITY OF THE ACUTE RESPIRATORY DISTRESS SYNDROME

BOULDER CREEK CZO II: EVOLUTION, FORM, FUNCTION, AND FUTURE OF THE CRITICAL ZONE

RESPIRATION AND CIRCULATION DURING HYPOXIA

THE COMPLEMENT SYSTEM AND ISCHEMIC ACUTE RENAL FAILURE

THE NIWOT RIDGE LONG-TERM ECOLOGICAL RESEARCH PROGRAM 2011-2016: TIPPING POINTS IN HIGH-ELEVATION ECOSYSTEMS IN RESPONSE TO CHANGES IN CLIMATE AND A

MOLECULAR ANALYSIS OF HINDBRAIN DEVELOPMENT

PUBLIC HEALTH TRAINING CENTERS

SOIL BLAST MODELING AND SIMULATION

REGULATION OF CHROMATIN SIGNALING IN HEART FAILURE BY BET BROMODOMAIN PROTEINS

MODEL STATE-SUPPORTED AHEC PROGRAM

MULTIPLE YEAR AWARD&INCREMENTAL FUNDING FOR YEARS ONE OF FIVE. THIS PROPOSAL IS ENTITLED, "ROCK-POWERED LIFE: REVEALING MECHANISMS OF ENERGY FLOW FR

IN THIS PROJECT, CIESRDS SCIENTISTS WILL ADDRESS KNOWN GAPS IN NOAA'S COASTAL INUNDATION AND FLOOD-RELATED DATA MANAGEMENT AND DECISION SUPPORT SERVICES. IT WILL EXPAND NESDIS'S CAPACITY TO EFFECTIVELY STEWARD ALL THE RELEVANT DATA TYPES NEEDED FOR RISK MANAGEMENT, AND DEVELOP USE INSPIRED SCIENCE BASED PRODUCTS AND SERVICES. THESE INCLUDE DIGITAL ELEVATION MODELS, AND UPDATES TO ETOPO. PART OF LEVERAGING THE BIL FUNDS WILL INCLUDE MIGRATION OF THESE ACTIVITIES TO CLOUD BASED INFRASTRUCTURE TO ENHANCE THE ACCESSIBILITY AND USABILITY OF THE DATA AND ASSOCIATED PRODUCTS.

INCREASED CONNECTIVITY IN A POLAR DESERT RESULTING FROM CLIMATE WARMING: MCMURDO DRY VALLEY LTER PROGRAM

ROLE OF SYNDECANS IN SATELLITE CELL FUNCTION

A PROSPECTIVE, RANDOMIZED INVESTIGATION OF "PLASMA FIRST RESUSCITATION" FOR TRAUMATIC HEMORRHAGE AND ATTENUATION OF THE ACUTE COAGULOPATHY OF TRAUMA

FUNDING OPPORTUNITY ANNOUNCEMENT: SENSING EXPORTS OF ANTHROPOGENIC CARBON THROUGH OCEAN OBSERVATION (SEA CO2) TO OBTAIN A COPY OF THE FUNDING OPPORTUNITY ANNOUNCEMENT (FOA) PLEASE GO TO THE ARPA-E WEBSITE ATHTTPS://ARPA-E-FOA.ENERGY.GOV. TO APPLY TO THIS FOA, APPLICANTS MUST REGISTER WITH AND SUBMIT APPLICATIONMATERIALS THROUGH ARPA-E EXCHANGE (HTTPS://ARPA-E-FOA.ENERGY.GOV/REGISTRATION.ASPX). FOR DETAILEDGUIDANCE ON USING ARPA-E EXCHANGE, PLEASE REFER TO THE ARPA-E EXCHANGE USER GUIDE (HTTPS://ARPA-E-FOA.ENERGY.GOV/MANUALS.ASPX). ARPA-E WILL NOT REVIEW OR CONSIDER CONCEPT PAPERS SUBMITTED THROUGHOTHER MEANS. FOR PROBLEMS WITH ARPA-E EXCHANGE, EMAIL EXCHANGEHELP@HQ.DOE.GOV (WITH FOA NAMEAND NUMBER IN THE SUBJECT LINE). QUESTIONS ABOUT THIS FOA? CHECK THE FREQUENTLY ASKED QUESTIONS AVAILABLE AT HTTP://ARPA-E.ENERGY.GOV/FAQ. FOR QUESTIONS THAT HAVE NOT ALREADY BEEN ANSWERED, EMAIL ARPA-E-CO@HQ.DOE.GOV. TO OBTAIN A COPY OF THE FUNDING OPPORTUNITY ANNOUNCEMENT (FOA) PLEASE GO TO THE ARPA-E WEBSITE ATHTTPS://ARPA-E-FOA.ENERGY.GOV. TO APPLY TO THIS FOA, APPLICANTS MUST REGISTER WITH AND SUBMIT APPLICATIONMATERIALS THROUGH ARPA-E EXCHANGE (HTTPS ://ARPA-E-FOA.ENERGY.GOV/REGISTRATION.ASPX). FOR DETAILED GUIDANCE ON USING ARPA-E EXCHANGE, PLEASE REFER TO THE ARPA-E EXCHANGE USER GUIDE (HTTPS://ARPA-E-FOA.ENERGY.GOV/MANUALS.ASPX). ARPA-E WILL NOT REVIEW OR CONSIDER CONCEPT PAPERS SUBMITTED THROUGH OTHER MEANS. FOR PROBLEMS WITH ARPA-E EXCHANGE, EMAIL EXCHANGEHELP@HQ.DOE.GOV (WITH FOA NAME AND NUMBER IN THE SUBJECT LINE). QUESTIONS ABOUT THIS FOA? CHECK THE FREQUENTLY ASKED QUESTIONS AVAILABLE AT HTTP://ARPA-E.ENERGY.GOV/FAQ. FOR QUESTIONS THAT HAVE NOT ALREADY BEEN ANSWERED, EMAIL ARPA-E-CO@HQ.DOE.GOV. AGENCY OVERVIEW THE ADVANCED RESEARCH PROJECTS AGENCY – ENERGY (ARPA-E), AN ORGANIZATION WITHIN THE DEPARTMENT OF ENERGY (DOE), IS CHARTERED BY CONGRESS IN THE AMERICA COMPETES ACT OF 2007 (P.L. 110-69), AS AMENDED BY THE AMERICA COMPETES REAUTHORIZATION ACT OF 2010 (P.L. 111-358), AS FURTHER AMENDED BY THE ENERGY ACT OF 2020 (P.L. 116-260): “(A) TO ENHANCE THE ECONOMIC AND ENERGY SECURITY OF THE UNITED STATES THROUGH THE DEVELOPMENT OF ENERGY TECHNOLOGIES THAT— (I) REDUCE IMPORTS OF ENERGY FROM FOREIGN SOURCES; (II) REDUCE ENERGY-RELATED EMISSIONS, INCLUDING GREENHOUSE GASES; (III) IMPROVE THE ENERGY EFFICIENCY OF ALL ECONOMIC SECTORS; (IV) PROVIDE TRANSFORMATIVE SOLUTIONS TO IMPROVE THE MANAGEMENT, CLEAN-UP, AND DISPOSAL OF RADIOACTIVE WASTE AND SPENT NUCLEAR FUEL; AND (V) IMPROVE THE RESILIENCE, RELIABILITY, AND SECURITY OF INFRASTRUCTURE TO PRODUCE, DELIVER, AND STORE ENERGY; AND (B) TO ENSURE THAT THE UNITED STATES MAINTAINS A TECHNOLOGICAL LEAD IN DEVELOPING AND DEPLOYING ADVANCED ENERGY TECHNOLOGIES.” ARPA-E ISSUES THIS FUNDING OPPORTUNITY ANNOUNCEMENT (FOA) UNDER ITS AUTHORIZING STATUTE CODIFIED AT 42 U.S.C. § 16538. THE FOA AND ANY COOPERATIVE AGREEMENTS OR GRANTS MADE UNDER THIS FOA ARE SUBJECT TO 2 C.F.R. PART 200 AS SUPPLEMENTED BY 2 C.F.R. PART 910. ARPA-E FUNDS RESEARCH ON, AND THE DEVELOPMENT OF, TRANSFORMATIVE SCIENCE AND TECHNOLOGY SOLUTIONS TO ADDRESS THE ENERGY AND ENVIRONMENTAL MISSIONS OF THE DEPARTMENT. THE AGENCY FOCUSES ON TECHNOLOGIES THAT CAN BE MEANINGFULLY ADVANCED WITH A MODEST INVESTMENT OVER A DEFINED PERIOD OF TIME IN ORDER TO CATALYZE THE TRANSLATION FROM SCIENTIFIC DISCOVERY TO EARLY-STAGE TECHNOLOGY. FOR THE LATEST NEWS AND INFORMATION ABOUT ARPA-E, ITS PROGRAMS AND THE RESEARCH PROJECTS CURRENTLY SUPPORTED, SEE: HTTP://ARPA-E.ENERGY.GOV/. ARPA-E FUNDS TRANSFORMATIONAL RESEARCH. EXISTING ENERGY TECHNOLOGIES GENERALLY PROGRESS ON ESTABLISHED “LEARNING CURVES” WHERE REFINEMENTS TO A TECHNOLOGY AND THE ECONOMIES OF SCALE THAT ACCRUE AS MANUFACTURING AND DISTRIBUTION DEVELOP DRIVE IMPROVEMENTS TO THE COST/PERFORMANCE METRIC IN A GRADUAL FASHION. THIS CONTINUAL IMPROVEMENT OF A TECHNOLOGY IS IMPORTANT TO ITS INCREASED COMMERCIAL DEPLOYMENT AND IS APPROPRIATELY THE FOCUS OF THE PRIVATE SECTOR OR THE APPLIED TECHNOLOGY OFFICES WITHIN DOE. BY CONTRAST, ARPA-E SUPPORTS TRANSFORMATIVE RESEARCH THAT HAS THE POTENTIAL TO CREATE FUNDAMENTALLY NEW LEARNING CURVES. ARPA-E TECHNOLOGY PROJECTS TYPICALLY START WITH COST/PERFORMANCE ESTIMATES WELL ABOVE THE LEVEL OF AN INCUMBENT TECHNOLOGY. GIVEN THE HIGH RISK INHERENT IN THESE PROJECTS, MANY WILL FAIL TO PROGRESS, BUT SOME MAY SUCCEED IN GENERATING A NEW LEARNING CURVE WITH A PROJECTED COST/PERFORMANCE METRIC THAT IS SIGNIFICANTLY BETTER THAN THAT OF THE INCUMBENT TECHNOLOGY. ARPA-E FUNDS TECHNOLOGY WITH THE POTENTIAL TO BE DISRUPTIVE IN THE MARKETPLACE. THE MERE CREATION OF A NEW LEARNING CURVE DOES NOT ENSURE MARKET PENETRATION. RATHER, THE ULTIMATE VALUE OF A TECHNOLOGY IS DETERMINED BY THE MARKETPLACE, AND IMPACTFUL TECHNOLOGIES ULTIMATELY BECOME DISRUPTIVE – THAT IS, THEY ARE WIDELY ADOPTED AND DISPLACE EXISTING TECHNOLOGIES FROM THE MARKETPLACE OR CREATE ENTIRELY NEW MARKETS. ARPA-E UNDERSTANDS THAT DEFINITIVE PROOF OF MARKET DISRUPTION TAKES TIME, PARTICULARLY FOR ENERGY TECHNOLOGIES. THEREFORE, ARPA-E FUNDS THE DEVELOPMENT OF TECHNOLOGIES THAT, IF TECHNICALLY SUCCESSFUL, HAVE CLEAR DISRUPTIVE POTENTIAL, E.G., BY DEMONSTRATING CAPABILITY FOR MANUFACTURING AT COMPETITIVE COST AND DEPLOYMENT AT SCALE. ARPA-E FUNDS APPLIED RESEARCH AND DEVELOPMENT. THE OFFICE OF MANAGEMENT AND BUDGET DEFINES “APPLIED RESEARCH” AS AN “ORIGINAL INVESTIGATION UNDERTAKEN IN ORDER TO ACQUIRE NEW KNOWLEDGE…DIRECTED PRIMARILY TOWARDS A SPECIFIC PRACTICAL AIM OR OBJECTIVE” AND DEFINES “EXPERIMENTAL DEVELOPMENT” AS “CREATIVE AND SYSTEMATIC WORK, DRAWING ON KNOWLEDGE GAINED FROM RESEARCH AND PRACTICAL EXPERIENCE, WHICH IS DIRECTED AT PRODUCING NEW PRODUCTS OR PROCESSES OR IMPROVING EXISTING PRODUCTS OR PROCESSES.”1 APPLICANTS INTERESTED IN RECEIVING FINANCIAL ASSISTANCE FOR BASIC RESEARCH (DEFINED BY THE OFFICE OF MANAGEMENT AND BUDGET AS “EXPERIMENTAL OR THEORETICAL WORK UNDERTAKEN PRIMARILY TO ACQUIRE NEW KNOWLEDGE OF THE UNDERLYING FOUNDATIONS OF PHENOMENA AND OBSERVABLE FACTS”)2 SHOULD CONTACT THE DOE’S OFFICE OF SCIENCE (HTTP://SCIENCE.ENERGY.GOV/). OFFICE OF SCIENCE NATIONAL SCIENTIFIC USER FACILITIES (HTTP://SCIENCE.ENERGY.GOV/USER-FACILITIES/) ARE OPEN TO ALL RESEARCHERS, INCLUDING ARPA-E APPLICANTS AND AWARDEES. THESE FACILITIES PROVIDE ADVANCED TOOLS OF MODERN SCIENCE INCLUDING ACCELERATORS, COLLIDERS, SUPERCOMPUTERS, LIGHT SOURCES AND NEUTRON SOURCES, AS WELL AS FACILITIES FOR STUDYING THE NANOWORLD, THE ENVIRONMENT, AND THE ATMOSPHERE. PROJECTS FOCUSED ON EARLY-STAGE R&D FOR THE IMPROVEMENT OF TECHNOLOGY ALONG DEFINED ROADMAPS MAY BE MORE APPROPRIATE FOR SUPPORT THROUGH THE DOE APPLIED ENERGY OFFICES INCLUDING: THE OFFICE OF ENERGY EFFICIENCY AND RENEWABLE ENERGY (HTTP://WWW.EERE.ENERGY.GOV/), THE OFFICE OF FOSSIL ENERGY AND CARBON MANAGEMENT (HTTPS://WWW.ENERGY.GOV/FECM/OFFICE-FOSSIL-ENERGY-AND-CARBON-MANAGEMENT), THE OFFICE OF NUCLEAR ENERGY (HTTP://WWW.ENERGY.GOV/NE/OFFICE-NUCLEAR-ENERGY), AND THE OFFICE OF ELECTRICITY (HTTPS://WWW.ENERGY.GOV/OE/OFFICE-ELECTRICITY). PROGRAM OVERVIEW MARINE CARBON DIOXIDE REMOVAL (MCDR) WILL BE AN ESSENTIAL COMPONENT OF A FUTURE NEGATIVE EMISSIONS INDUSTRY, WHICH ALONGSIDE EMISSIONS REDUCTION IS NECESSARY TO RESTRICT CLIMATE WARMING TO LESS THAN 2°C AND AVOID GLOBAL, IRREVERSIBLE, AND CATASTROPHIC CHANGES CAUSED BY THIS TEMPERATURE RISE. THIS PROGRAM SEEKS TO ACCELERATE THE DEVELOPMENT OF THE MCDR INDUSTRY THROUGH THE DEVELOPMENT OF SCALABLE MEASUREMENT, REPORTING AND VALIDATION (MRV) TECHNOLOGIES. MRV MUST BE OF SUFFICIENT QUALITY TO QUANTIFY CARBON DRAWDOWN MAGNITUDES, THE DEGREE OF PERMANENCE, AND BOUND THE UNCERTAINTIES ASSOCIATED WITH THESE PARAMETERS SO THAT CARBON MARKETS CAN ASCERTAIN CREDIT QUALITY AND FINANCIAL INSTITUTIONS CAN MAKE INFORMED DECISIONS REGARDING INVESTMENT RISK. TO ACHIEVE THESE GOALS, A PARADIGM SHIFT IN CHEMICAL OCEANOGRAPHIC DATA COLLECTION IS REQUIRED, MOVING FROM A SINGLE-POINT COLLECTION PARADIGM TOWARDS A GOAL OF PERSISTENT SENSING OF PARAMETERS ACROSS LARGE AREAS AND/OR VOLUMES. TO VIEW THE FOA IN ITS ENTIRETY, PLEASE VISIT HTTPS://ARPA-E-FOA.ENERGY.GOV.

A ROADMAP TO EVIDENCE-BASED SCHOOL SAFETY: SAFE COMMUNITIES SAFE SCHOOLS

NEW; SISGR: ULTRAFAST MAGNETISM DYNAMICS MESAURE USING TABLETOP ULTRAFAST EUV SOURCES; PI- MARGARET MURNANE

MOLECULAR ANALYSIS MODELING AND CORRECTION OF SKIN DISEASES

PREVENTION CENTER U01: EARLY TARGETS FOR ANTIGEN-SPECIFIC TOLERANCE INDUCTION FOR

POST-DPP FOLLOW-UP STUDY

THE ROLE OF MTOR SIGNALING IN OLIGODENDROCYTE DIFFERENTIATION AND CNS MYELINATION

FUNDAMENTAL MECHANISMS OF APOPTOSIS AND PHOSPHOLIPID ASYMMETRY