Rhoe Corp

THE PURPOSE OF THIS PROJECT IS TO IMPROVE THE TB CARE (E.G. PREVENTION OF TB, BETTER CASE DETECTION, DIAGNOSIS, PROMPT TREATMENT, IMPROVED TREATMENT OUTCOMES, STRONG REFERRAL NETWORK, ACTIVE MONITORING, AND REPORTING OF ALL FORMS OF TB) IN THE SELECTED GEOGRAPHIC AREAS OF BANGLADESH. THE ACTIVITY WILL ALSO ENSURE BETTER ENGAGEMENT OF THE PRIVATE SECTOR AND COORDINATION WITH THE EXISTING USAID FUNDED ACTIVITIES AND GLOBAL FUND ACTIVITIES.

ADDRESSING EMERGING INFECTIOUS DISEASES IN BANGLADESH

ADVANCING PUBLIC HEALTH RESEARCH IN BANGLADESH

ADDRESSING EMERGING INFECTIONS DISEASE IN BANGLADESH

USAID'S RESEARCH FOR DECISION MAKERS ACTIVITY

RFA-GH-24-033, ADVANCING PUBLIC HEALTH RESEARCH IN BANGLADESH

EFFICACY OF OSELTAMIVIR IN REDUCING DURATION OF ILLNESS, VIRAL SHEDDING & TRANSIS

1/2 BANGLADESH CENTER FOR GLOBAL ENVIRONMENTAL AND OCCUPATIONAL HEALTH -BANGLADESH

ENHANCING GLOBAL HEALTH SECURITY: EXPANDING EFFORTS AND STRATEGIES TO PROTECT AND IMPROVE PUBLIC HEALTH GLOBALLY

STRENGTHENING PUBLIC HEALTH CAPACITY IN BANGLADESH

STRENGTHENING PUBLIC HEALTH CAPACITY IN BANGLADESH

STRENGTHENING FUNGAL DISEASE SURVEILLANCE AND CAPACITY IN BANGLADESH

ASSIST NATIONAL FILARIA ELIMINATION PROGRAMME IN BANGLADESH ON PREPAREDNESS OF POST ELIMINATION PERIOD

TRANSMISSION DYNAMICS OF MULTI-DRUG RESISTANT UROPATHOGENIC E. COLI IN BANGLADESH

DEFINING CAMPYLOBACTER AND IMMUNE RESPONSE RELATED DETERMINANTS IN THE PATHOGENESIS OF GUILLAIN-BARR? SYNDROME PATIENTS IN LOW-INCOME COUNTRIES

EARLY-MILQ (E-MILQ) STUDY TO COLLECT AND ANALYZE HUMAN MILK DURING THE FIRST MONTH POSTPARTUM - THE ONGOING MILQ STUDY HAS SUCCESSFULLY COLLECTED COLOSTRUM (AT 2-3 DAYS POSTPARTUM) AND THEN BREAST MILK FROM 1 MONTH THROUGH 8.5 MONTHS POSTPARTUM. MILK SAMPLES WERE NOT COLLECTED DURING THE FIRST MONTH BECAUSE OF INVESTIGATOR'S CONCERN THAT ADDING MILK COLLECTION (ACCOMPANIED BY A GREAT DEAL OF ADDITIONAL INFORMATION ON MOTHERS AND INFANTS AS COLLECTED AT ALL VISITS) DURING THE FIRST FEW WEEKS AFTER BIRTH WOULD RESULT IN UNACCEPTABLE RATES OF REFUSAL TO ENROLL AND EARLY DROP-OUTS DURING THIS STRESSFUL PERIOD. HOWEVER, SAMPLE COLLECTION FROM 1 TO 8.5 MONTHS HAS PROCEEDED EXCEPTIONALLY WELL WITH FEWER DROP-OUTS THAN EXPECTED AT ALL FOUR SITES. AT THIS TIME THE INVESTIGATORS BELIEVE THAT WE COULD ADD A FOLLOW-ON, SEPARATE STUDY OF MILK COMPOSITION AND VOLUME BETWEEN BIRTH AND 1 MONTH POSTPARTUM, AND THAT THIS WOULD BE WELL-ACCEPTED BY PARTICIPANTS. HAVING THIS INFORMATION ON MILK COMPOSITION AND VOLUME DURING THE FIRST MONTH WILL ENABLE US TO: * COMPLETE THE OTHERWISE CONTINUOUS COMPOSITION CURVES FROM 1 TO 8.5 MONTHS WITH DATA FROM BIRTH THROUGH 1 MONTH. * MEASURE THE AVERAGE 14-DAY MILK VOLUME FOR EACH PARTICIPANT ON A ROLLING BASIS BETWEEN 2 TO 3 DAYS POSTPARTUM AND 31 DAYS POSTPARTUM. * DETERMINE YOUNG INFANTS' NUTRIENT INTAKES FROM MILK. * DETECT STRONGER ASSOCIATIONS BETWEEN MATERNAL STATUS AND MILK CONCENTRATIONS. * OBTAIN REFERENCE VALUES FOR NUTRIENTS, AND DATA ON METABOLITES, HMOS AND BIOACTIVE PROTEINS IN EARLY MILK.

HUMORAL AND ADAPTIVE IMMUNE RESPONSES STUDY IN VIBRIO CHOLERAE INFECTION

HOST DEFENSE AGAINST SHIGELLA FLEXNERI

GUT MICROBIOME AND REGULATION ON IMMUNE RESPONSES IN GUILLAIN-BARRE SYNDROME: A PROSPECTIVE CONTROLLED STUDY - PROJECT SUMMARY GUILLAIN-BARRE SYNDROME (GBS) HAS BECOME A MAJOR HEALTH BURDEN IN LOW- AND MIDDLE-INCOME COUNTRIES (LMIC) AFTER POST-POLIO ERA. THE PROGNOSIS OF GBS HAS NOT IMPROVED OVER THE LAST TWO DECADES. OUR GROUP PREVIOUSLY SHOWED THAT THE INCIDENCE, DISEASE SEVERITY AND MORTALITY OF GBS ARE HIGHER IN BANGLADESH COMPARED TO THE DEVELOPED WORLD. LITTLE IS KNOWN ABOUT THE FACTORS THAT INFLUENCE DISEASE PATHOGENESIS AND SEVERITY IN PATIENTS WITH GBS IN LMIC. WE AIM TO IDENTIFY THE FIRMICUTES RICH SPECIES IN GUT MICROBIOME IN PATIENTS WITH GBS AND DETERMINE THE REGULATION OF T AND B CELL RESPONSES IMPOSED BY THE HOST MICROBIOME. THE MAIN HYPOTHESIS OF THE CURRENT PROJECT IS WHETHER GUT MICROBIOME PLAYS A VITAL ROLE IN REGULATION OF THE CELLULAR IMMUNE RESPONSE DURING THE PATHOGENESIS OF GBS. OUR SPECIFIC AIMS WILL TEST THE FOLLOWING HYPOTHESES: SPECIFIC AIM #1: WE WILL IDENTIFY AND COMPARE SPECIES FROM THE FIRMICUTES PHYLUM IN THE GUT MICROBIOME OF PATIENTS WITH GBS VERSUS UNCOMPLICATED CAMPYLOBACTER JEJUNI ENTERITIS CONTROLS AND CORRELATE BETWEEN GUT MICROBIAL INVOLVEMENT AND DISEASE SEVERITY IN PATIENTS WITH GBS. SPECIFIC AIM #2: WE WILL DETERMINE GUT MICROBIOME REGULATION OF T AND B CELL DIFFERENTIATION TO PREDICT IMMUNE TOLERANCE DURING DISEASE PROGRESSION AND IDENTIFY THE ASSOCIATION WITH THE SEVERITY OF GBS. THE CURRENT PROJECT IS THE VERY FIRST ATTEMPT TAKEN FROM LMIC TO FIND THE HOST GUT MICROBIOME FACTORS OF GBS PATIENTS. THIS STUDY WILL BE A COLLABORATIVE INITIATIVE BETWEEN UPPER AND MIDDLE IN-COME COUNTRIES (UMICS) AND LMICS TO EXPLORE THE PATHOGENESIS OF SUCH A LONG TERM NEUROLOGICAL DISORDER. THE AIMS PROPOSED IN THIS EXPLORATORY/DEVELOPMENTAL GRANT APPLICATION IS BUILT UPON ONGOING, LONG-STANDING COLLABORATIVE EFFORTS BETWEEN THE ICDDR,B (BANGLADESH), ERASMUS MC, UNIVERSITY MEDICAL CENTRE (ROTTERDAM, THE NETHERLANDS), THE UNIVERSITY OF CALIFORNIA (DAVIS, USA), JOHNS HOPKINS UNIVERSITY (BALTIMORE, USA) AND THE NATIONAL INSTITUTE OF NEUROSCIENCES & HOSPITAL (DHAKA, BANGLADESH). THIS EXPLORATORY STUDY WILL BE THE ROAD MAP TO UNDERSTAND THE GUT MICROBIOME REGULATION IN IMMUNE-PATHOGENESIS OF GBS AND IDENTIFY POTENTIAL THERAPEUTIC TARGETS IN FUTURE.

BANGLADESH CENTRE FOR GLOBAL ENVIRONMENTAL AND OCCUPATIONAL HEALTH

BANGLADESH NATIONAL INFLUENZA EPIDEMIOLOGY

THE GOAL OF THIS PROJECT IS TO REDUCE HUMAN EXPOSURE TO LEAD BY ANALYZING THE PRIMARY SOURCES OF LEAD EXPOSURE IN THE SELECTED COUNTRIES, AND IDENTIFYING AND IMPLEMENTING METHODS FOR MITIGATING EXPOSURE.

IMPACT OF FOODS HIGH IN CAROTENOIDS ON PLASMA AND BREASTMILK IN LACTATING BANGLADESHI WOMEN

IMPACT OF FOODS HIGH IN CAROTENOIDS ON PLASMA AND BREASTMILK IN LACTATING BANGLADESHI WOMEN

NEWBORN VITAMIN A SUPPLEMENTATION

PLANNING FOR NON-COMMUNICABLE DISEASES AND DISORDERS RESEARCH TRAINING PROGRAMS IN BANGLADESH

NEWBORN VITAMIN A SUPPLEMENTATION

NEWBORN VITAMIN A SUPPLEMENTATION

NEWBORN VITAMIN A SUPPLEMENTS, GUT MICROBIOTA, AND VACCINE RESPONSE AT 15-18M IN BANGLADESHI INFANTS

NEWBORN VITAMIN A SUPPLEMENTS, GUT MICROBIOTA, AND VACCINE RESPONSE AT 15-18M IN BANGLADESHI INFANTS

NEWBORN VITAMIN A SUPPLEMENTATION

NEWBORN VITAMIN A SUPPLEMENTS, GUT MICROBIOTA, AND VACCINE RESPONSE AT 15-18M IN BANGLADESHI INFANTS

NEWBORN VITAMIN A SUPPLEMENTS, GUT MICROBIOTA, AND VACCINE RESPONSE AT 15-18M IN BANGLADESHI INFANTS

ASSESSING THE QUALITY OF BREAST MILK

NEWBORN VITAMIN A SUPPLEMENTATION

IMPACT OF FOODS HIGH IN CAROTENOIDS ON PLASMA AND BREASTMILK IN LACTATING BANGLADESHI WOMEN

NEWBORN VITAMIN A SUPPLEMENTS, GUT MICROBIOTA, AND VACCINE RESPONSE AT 15-18M IN BANGLADESHI INFANTS

NEWBORN VITAMIN A SUPPLEMENTS, GUT MICROBIOTA, AND VACCINE RESPONSE AT 15-18M IN BANGLADESHI INFANTS

THE PURPOSE OF THIS MODIFICATION IS TO EXTEND THE ESTIMATED COMPLETION DATE TO JUNE 30 2008.