Loading organization details...
Loading organization details...
See Schedule O.
Source: IRS Form 990 (Tax Year 2024)
Source: IRS e-Filed Form 990 (from the IRS e-File system), Tax Year 2023
Total Revenue
▼$3.3B
Program Spending
85%
of total expenses go to program services
Total Contributions
$791.1M
Total Expenses
▼$2.2B
Total Assets
$26.7B
Total Liabilities
▼$4.6B
Net Assets
$22.1B
Officer Compensation
→$13.5M
Other Salaries
$761.1M
Investment Income
$1.2B
Fundraising
▼$618.2K
Tax Year 2023 · Source: IRS Form 990, Schedule I (Grants and Other Assistance)
Total grants awarded: $42M
| Recipient | Location | Amount | Type | Purpose |
|---|---|---|---|---|
The Lord's Place Inc59-2240502 | West Palm Beach, FL | $2.1M | Cash | See Part IV |
University of California Berkeley94-6002123 | Berkeley, CA | $1.4M | Cash | See Part IV |
South Bend Elkhart Regional Partner35-1893288 | South Bend, IN | $1.3M | Cash | See Part IV |
Henry M Jackson Foundation52-1317896 | Bethesda, MD | $1.2M | Cash | See Part IV |
Christ Child Society of Detroit38-1404582 | Detroit, MI | $1.1M | Cash | See Part IV |
Johns Hopkins University52-0595110 | Baltimore, MD | $1M | Cash | See Part IV |
University of Chicago36-2177139 | Chicago, IL | $1M | Cash | See Part IV |
Georgia Tech Research Corporation58-0603146 | Atlanta, GA | $976.2K | Cash | See Part IV |
University of Illinois37-6000511 | Urbana, IL | $965.6K | Cash | See Part IV |
enFocus Inc45-5638209 | South Bend, IN | $852.6K | Cash | See Part IV |
University of California Los Angeles95-6006143 | Los Angeles, CA | $771.1K | Cash | See Part IV |
University of Utah87-6000525 | Salt Lake City, UT | $751.5K | Cash | See Part IV |
Purdue University35-6002041 | West Lafayette, IN | $717.9K | Cash | See Part IV |
Northwestern University36-2167817 | Evanston, IL | $654K | Cash | See Part IV |
Indiana University35-6001673 | Bloomington, IN | $653.3K | Cash | See Part IV |
Vanguard Charitable23-2888152 | Warwick, RI | $600K | Cash | See Part IV |
University of California San Diego95-6006144 | La Jolla, CA | $582.9K | Cash | See Part IV |
California Institute of Technology95-1643307 | Pasadena, CA | $577.5K | Cash | See Part IV |
Stanford University94-1156365 | Stanford, CA | $558.7K | Cash | See Part IV |
Cornell University15-0532082 | Ithaca, NY | $543.7K | Cash | See Part IV |
Henderson Behavioral Health Inc59-0711167 | Lauderdale Lakes, FL | $500K | Cash | See Part IV |
The Catholic Foundation75-1106620 | Dallas, TX | $500K | Cash | See Part IV |
Carnegie Mellon University25-0969449 | Pittsburgh, PA | $495.1K | Cash | See Part IV |
Mathematica Policy Research22-2112296 | Princeton, NJ | $461.6K | Cash | See Part IV |
Massachusetts Institute of Technology04-2103594 | Cambridge, MA | $443.3K | Cash | See Part IV |
University of Virginia54-6001796 | Charlottesville, VA | $421.9K | Cash | See Part IV |
University of Minnesota41-6007513 | Minneapolis, MN | $413.5K | Cash | See Part IV |
Duke University56-0532129 | Durham, NC | $407.5K | Cash | See Part IV |
University of Colorado84-6000555 | Denver, CO | $406.1K | Cash | See Part IV |
Saint Mary's College35-0868158 | Notre Dame, IN | $399.6K | Cash | See Part IV |
University of North Carolina56-6001393 | Chapel Hill, NC | $366.8K | Cash | See Part IV |
Holy Cross College35-1148835 | Notre Dame, IN | $333.1K | Cash | See Part IV |
University of Texas Southwestern75-6002868 | Dallas, TX | $289.5K | Cash | See Part IV |
Boston College04-2103545 | Chestnut Hill, MA | $288.2K | Cash | See Part IV |
University of Michigan38-6006309 | Ann Arbor, MI | $252.4K | Cash | See Part IV |
University of Iowa42-6004813 | Iowa City, IA | $251.1K | Cash | See Part IV |
Intellectually Developmentally Disabled Community Foundation87-4001536 | Boca Raton, FL | $250K | Cash | See Part IV |
Nuestra Senora De La Vivienda Community Foundation88-2551603 | Boca Raton, FL | $250K | Cash | See Part IV |
X Prize Foundation Inc52-1876879 | Culver City, CA | $250K | Cash | See Part IV |
Associated Universities Inc11-1630900 | Washington, DC | $239.3K | Cash | See Part IV |
Iskali82-1662711 | Stone Park, IL | $227K | Cash | See Part IV |
Vanderbilt University62-0476822 | Nashville, TN | $225.2K | Cash | See Part IV |
Florida International University65-0177616 | Miami, FL | $219.3K | Cash | See Part IV |
Open Environmental Data Inc86-2759780 | Hudson, NY | $216.5K | Cash | See Part IV |
Cultivate Food Rescue81-3306113 | South Bend, IN | $214K | Cash | See Part IV |
Summits Education47-2768711 | Boston, MA | $209.8K | Cash | See Part IV |
General Electric Corporation14-0689340 | Pittsburgh, PA | $208K | Cash | See Part IV |
Montana State University81-6010045 | Bozeman, MT | $203.1K | Cash | See Part IV |
University of Texas Dallas75-1305566 | Richardson, TX | $200.3K | Cash | See Part IV |
Early Childhood Development Center31-1188922 | Notre Dame, IN | $200K | Cash | See Part IV |
Eisenhower Medical Center95-6130458 | Rancho Mirage, CA | $200K | Cash | See Part IV |
University of Maryland52-6002033 | College Park, MD | $198.2K | Cash | See Part IV |
Clemson University57-6000254 | Clemson, SC | $195K | Cash | See Part IV |
University of Rochester16-0743209 | Rochester, NY | $194.2K | Cash | See Part IV |
University of Arkansas71-0236904 | Little Rock, AR | $191.1K | Cash | See Part IV |
University of Memphis62-6048540 | Memphis, TN | $190.4K | Cash | See Part IV |
Loyola University Chicago36-1408475 | Chicago, IL | $190.2K | Cash | See Part IV |
Colorado State University84-6000545 | Fort Collins, CO | $190.1K | Cash | See Part IV |
Southern Methodist University75-0800689 | Dallas, TX | $185.5K | Cash | See Part IV |
University at Albany SUNY14-1368361 | Albany, NY | $185.2K | Cash | See Part IV |
FGC Plasma Solutions Inc84-5138497 | Middleton, MA | $180.9K | Cash | See Part IV |
Iowa State University42-6004224 | Ames, IA | $174.7K | Cash | See Part IV |
Center for the Homeless35-1768544 | South Bend, IN | $170.9K | Cash | See Part IV |
University of Pittsburgh25-0965591 | Pittsburgh, PA | $168.1K | Cash | See Part IV |
Washington State University91-6001108 | Pullman, WA | $161.2K | Cash | See Part IV |
Northeastern University04-1679980 | Boston, MA | $160K | Cash | See Part IV |
Arizona State University86-0196696 | Tempe, AZ | $152.5K | Cash | See Part IV |
Georgetown University53-0196603 | Washington, DC | $145.6K | Cash | See Part IV |
Space Tango84-3437964 | Lexington, KY | $140K | Cash | See Part IV |
University of Puerto Rico Mayaguez66-0433761 | Mayaguez, PR | $130.5K | Cash | See Part IV |
University of Maine01-6000769 | Orono, ME | $129.5K | Cash | See Part IV |
Michiana Partnership Inc80-0688483 | South Bend, IN | $129.2K | Cash | See Part IV |
Case Western Reserve University34-1018992 | Cleveland, OH | $127.6K | Cash | See Part IV |
Oregon State University61-1730890 | Corvallis, OR | $126.9K | Cash | See Part IV |
Logan Community Resources35-0965639 | South Bend, IN | $125K | Cash | See Part IV |
Pope Francis Center81-2516039 | Detroit, MI | $125K | Cash | See Part IV |
Manhattan College13-1740468 | Riverdale, NY | $123K | Cash | See Part IV |
East Carolina University56-6093187 | Greenville, NC | $120K | Cash | See Part IV |
Forty Carrots of Sarasota Inc65-0405988 | Sarasota, FL | $120K | Cash | See Part IV |
International Research & Exchanges22-3087809 | Washington, DC | $116.8K | Cash | See Part IV |
Friends of The Cultural Center Inc95-2834871 | Palm Desert, CA | $115.1K | Cash | See Part IV |
Holy Cross Missions52-6044122 | Notre Dame, IN | $115K | Cash | See Part IV |
Clinton Health Access Initiative27-1414646 | Boston, MA | $113.9K | Cash | See Part IV |
College of William and Mary54-6001718 | Williamsburg, VA | $113.7K | Cash | See Part IV |
Illinois Institute of Technology36-2170136 | Chicago, IL | $113.3K | Cash | See Part IV |
The HDF Group68-0600605 | Champaign, IL | $110.8K | Cash | See Part IV |
Congregation of Holy Cross32-0344245 | Notre Dame, IN | $110K | Cash | See Part IV |
University of Washington91-6001537 | Seattle, WA | $108K | Cash | See Part IV |
Children's Hospital Medical Center31-0833936 | Cincinnati, OH | $107.5K | Cash | See Part IV |
Joan & Sanford I Weill Medical College13-1623978 | New York, NY | $107K | Cash | See Part IV |
University of California Irvine95-2226406 | Irvine, CA | $106.9K | Cash | See Part IV |
Center for Disease Control58-6051157 | Atlanta, GA | $105.9K | Cash | See Part IV |
University of California Davis94-6036494 | Davis, CA | $103.6K | Cash | See Part IV |
University Corporation for Atmospheric Research74-2439386 | Boulder, CO | $101.9K | Cash | See Part IV |
| Washington, DC | $100K | Cash | See Part IV | |
Champions Community Foundation Inc47-2058404 | Alpharetta, GA | $100K | Cash | See Part IV |
Cross Catholic Outreach65-1156061 | Washington, DC | $100K | Cash | See Part IV |
JDRF International23-1907729 | New York, NY | $100K | Cash | See Part IV |
Our Lady of Mercy Church & School52-0733733 | Potomac, MD | $100K | Cash | See Part IV |
Roman Catholic Diocese of Charlotte56-1000633 | Charlotte, NC | $100K | Cash | See Part IV |
Rutgers University22-6001086 | Branchville, NJ | $100K | Cash | See Part IV |
St Mary Catholic Church65-0057156 | Pahokee, FL | $100K | Cash | See Part IV |
Teak Fellowship Inc13-4011465 | New York, NY | $100K | Cash | See Part IV |
The Catholic Association Foundation20-2387967 | Washington, DC | $100K | Cash | See Part IV |
| Teaneck, NJ | $100K | Cash | See Part IV | |
University of Wyoming83-6000331 | Laramie, WY | $91.4K | Cash | See Part IV |
Naval Postgraduate School23-7098729 | Monterey, CA | $87.4K | Cash | See Part IV |
Clubhouse of St Joseph County46-4865039 | South Bend, IN | $85K | Cash | See Part IV |
Van Buren Conservation District38-3028225 | Paw Paw, MI | $80.2K | Cash | See Part IV |
Scripps Research Institute33-0435954 | La Jolla, CA | $80K | Cash | See Part IV |
Harvard University04-2103580 | Cambridge, MA | $78.2K | Cash | See Part IV |
Tulane University72-0423889 | New Orleans, LA | $77.8K | Cash | See Part IV |
Cleveland Clinic Foundation34-0714585 | Cleveland, OH | $76.4K | Cash | See Part IV |
Catholic Education Foundation61-1294640 | Louisville, KY | $75K | Cash | See Part IV |
Cross International65-1086387 | Pompano Beach, FL | $75K | Cash | See Part IV |
The Way Church of Tampa Bay81-4922891 | Tampa, FL | $75K | Cash | See Part IV |
Villanova University23-1352688 | Villanova, PA | $75K | Cash | See Part IV |
Community Foundation of St Joseph County23-7365930 | South Bend, IN | $73.5K | Cash | See Part IV |
New Mexico State University85-6000401 | Las Cruces, NM | $70.4K | Cash | See Part IV |
Acquinas Institute of Theology43-1233793 | St Louis, MO | $70K | Cash | See Part IV |
Dartmouth College02-0222111 | Hanover, NH | $69.2K | Cash | See Part IV |
Industrial Arts Institute Inc46-3997543 | Onaway, MI | $67.5K | Cash | See Part IV |
University of Texas at Austin74-6000203 | Austin, TX | $65.5K | Cash | See Part IV |
Duality Technologies Inc82-0637666 | Hoboken, NJ | $65.1K | Cash | See Part IV |
Barry University59-0624364 | Miami, FL | $65K | Cash | See Part IV |
South Bend Regional Chamber35-0153330 | South Bend, IN | $65K | Cash | See Part IV |
Texas A&M Engineering Experiment Station74-1974733 | College Station, TX | $61.2K | Cash | See Part IV |
Ohio State University31-6025986 | Columbus, OH | $60.5K | Cash | See Part IV |
Divine Mercy Corporation52-2352651 | Boyds, MD | $60K | Cash | See Part IV |
Social Good Fund46-1323531 | Richmond, CA | $60K | Cash | See Part IV |
Alice International Inc26-4831665 | Milford, NH | $59.2K | Cash | See Part IV |
Aerojet Rocketdyne95-1751500 | Segundo, CA | $57.8K | Cash | See Part IV |
Goshen College35-2158366 | Goshen, IN | $56.4K | Cash | See Part IV |
Diocese of Metuchen22-2385423 | Piscataway, NJ | $55.5K | Cash | See Part IV |
Foundation for Tomorrow20-5970104 | Charlotte, NC | $55.1K | Cash | See Part IV |
Mount St Mary's University95-1641455 | Los Angeles, CA | $55K | Cash | See Part IV |
West Virginia University55-6000842 | Morgantown, WV | $54.6K | Cash | See Part IV |
Saint David's School13-1655283 | New York, NY | $54K | Cash | See Part IV |
St Vincent Hospital Foundation Inc35-6088862 | Indianapolis, IN | $53K | Cash | See Part IV |
All Faiths Food Bank Inc65-0115814 | Sarasota, FL | $50K | Cash | See Part IV |
Benjamin Private School Inc59-1536502 | North Palm Beach, FL | $50K | Cash | See Part IV |
| Chicago, IL | $50K | Cash | See Part IV | |
Columbia University13-5598093 | New York, NY | $50K | Cash | See Part IV |
Detroit Educational Television Foun38-1440200 | Wixom, MI | $50K | Cash | See Part IV |
Horizons for Youth36-3796784 | Chicago, IL | $50K | Cash | See Part IV |
International Samaritan34-1811907 | Ann Arbor, MI | $50K | Cash | See Part IV |
Maine Coast Heritage Trust23-7099105 | Topsham, ME | $50K | Cash | See Part IV |
| Dayton, OH | $50K | Cash | See Part IV | |
McLean Hospital04-2697981 | Belmont, MA | $50K | Cash | See Part IV |
| Coral Gables, FL | $50K | Cash | See Part IV | |
St John Vianney Center23-1396815 | Downingtown, PA | $50K | Cash | See Part IV |
St Patrick's Church23-1353342 | Malvern, PA | $50K | Cash | See Part IV |
Honeywell International Inc22-2640650 | Phoenix, AZ | $49.8K | Cash | See Part IV |
University of Southern California95-1642394 | Los Angeles, CA | $48.5K | Cash | See Part IV |
St Elizabeth Parish Detroit38-1533881 | Detroit, MI | $48K | Cash | See Part IV |
DePaul University36-2167048 | Chicago, IL | $47.8K | Cash | See Part IV |
American Institutes for Research25-0965219 | Arlington, VA | $44.9K | Cash | See Part IV |
University of Arizona74-2652689 | Tucson, AZ | $44.1K | Cash | See Part IV |
Brandeis University04-2103552 | Waltham, MA | $43.1K | Cash | See Part IV |
Franciscan School of Theology94-1745605 | San Diego, CA | $41K | Cash | See Part IV |
Catholic Charities of Dallas75-2745221 | Dallas, TX | $40K | Cash | See Part IV |
Catholic Charities of Northern Nevada88-0339754 | Reno, NV | $40K | Cash | See Part IV |
Chicago Council on Global Affairs36-2181969 | Chicago, IL | $40K | Cash | See Part IV |
Declan Drumm Sullivan Memorial Fund27-6886934 | Long Grove, IL | $40K | Cash | See Part IV |
Selfless Love Foundation Inc47-4544148 | Jupiter, FL | $40K | Cash | See Part IV |
Semilla Nueva36-4671687 | Boise, ID | $40K | Cash | See Part IV |
St Francis Xavier Parish36-2171003 | Wilmette, IL | $40K | Cash | See Part IV |
Youth Haven Inc23-7065187 | Naples, FL | $40K | Cash | See Part IV |
Hillsdale College38-1374230 | Hillsdale, MI | $39K | Cash | See Part IV |
Ayiti Analytics84-4859623 | Silver Spring, MD | $38.3K | Cash | See Part IV |
University of Florida59-6002052 | Gainesville, FL | $37.6K | Cash | See Part IV |
Rice University74-1109620 | Houston, TX | $36.3K | Cash | See Part IV |
Fidelity Investment Charitable Gift11-0303001 | Boston, MA | $36K | Cash | See Part IV |
TERC04-6134355 | Cambridge, MA | $35.9K | Cash | See Part IV |
Children's Place At Home Safe Inc59-1935485 | Lake Worth, TX | $35K | Cash | See Part IV |
Fabretto Children's Foundation36-3894824 | Evanston, IL | $35K | Cash | See Part IV |
South Bend Symphony Orchestra35-6042189 | South Bend, IN | $35K | Cash | See Part IV |
Franklin W Olin College of Engineering06-1519057 | Needham, MA | $34.7K | Cash | See Part IV |
Boys & Girls Club-St Joseph County35-1329625 | South Bend, IN | $33.9K | Cash | See Part IV |
South Dakota School of Mines and Technology46-6000364 | Pierre, SD | $33.7K | Cash | See Part IV |
Barnard College13-1628149 | New York, NY | $33.7K | Cash | See Part IV |
Hospice Foundation30-0433147 | Mishawaka, IN | $30K | Cash | See Part IV |
American Association of Caregiving65-0866677 | Boca Raton, FL | $30K | Cash | See Part IV |
| Omaha, NE | $30K | Cash | See Part IV | |
Covenant House Florida Inc59-2323607 | Fort Lauderdale, FL | $30K | Cash | See Part IV |
Elevate Ventures Inc27-4118692 | Indianapolis, IN | $30K | Cash | See Part IV |
Food for the Poor Inc59-2174510 | Coconut Creek, FL | $30K | Cash | See Part IV |
| Indianapolis, IN | $30K | Cash | See Part IV | |
La Salle International Foundation Inc26-3706307 | Washington, DC | $30K | Cash | See Part IV |
Little Traverse Conservancy23-7267810 | Harbor Springs, MI | $30K | Cash | See Part IV |
Oblate School of Theology74-1357323 | San Antonio, TX | $30K | Cash | See Part IV |
| Immokalee, FL | $30K | Cash | See Part IV | |
Society of St Vincent De Paul Detroit38-1359592 | Detroit, MI | $30K | Cash | See Part IV |
Southeastern Food Bank59-3166797 | Ocoee, FL | $30K | Cash | See Part IV |
St Martha Catholic Church74-2066304 | Porter, TX | $30K | Cash | See Part IV |
St Nicholas Episcopal Church59-1113644 | Pompano Beach, FL | $30K | Cash | See Part IV |
University of the Incarnate Word74-1109661 | San Antonio, TX | $30K | Cash | See Part IV |
Michigan Technological University38-6005955 | Houghton, MI | $28.2K | Cash | See Part IV |
Texas Biomedical Research Institute74-1109630 | San Antonio, TX | $26.1K | Cash | See Part IV |
University of Texas at El Paso74-6000813 | El Paso, TX | $25.5K | Cash | See Part IV |
| Crest Hill, IL | $25.5K | Cash | See Part IV | |
University of Cincinnati31-6000989 | Cincinnati, OH | $25.3K | Cash | See Part IV |
Arc Broward Inc59-0809623 | Sunrise, FL | $25.3K | Cash | See Part IV |
ASSIA Inc74-3092365 | RDWC, CA | $25K | Cash | See Part IV |
ASU Foundation Inc23-7099379 | Boone, NC | $25K | Cash | See Part IV |
Baker Senior Center Naples Inc45-3980909 | Naples, FL | $25K | Cash | See Part IV |
Breukelein Institute11-3110813 | Brooklyn, NY | $25K | Cash | See Part IV |
Cornerstone of Hope34-1945499 | Independence, OH | $25K | Cash | See Part IV |
| Notre Dame, IN | $25K | Cash | See Part IV | |
Inspire Access Inc88-3094715 | Potomac, MD | $25K | Cash | See Part IV |
La Puente Home Inc74-2224631 | Alamosa, CO | $25K | Cash | See Part IV |
| Montclair, NJ | $25K | Cash | See Part IV | |
Live Action42-1764425 | Arlington, VA | $25K | Cash | See Part IV |
Mayo Clinic41-6011702 | Rochester, MN | $25K | Cash | See Part IV |
Mercy Ships Foundation75-2641151 | Garden Valley, TX | $25K | Cash | See Part IV |
Miami University Foundation Inc31-6026014 | Oxford, OH | $25K | Cash | See Part IV |
Milwaukee Bucks Foundation Inc47-3620094 | Milwaukee, WI | $25K | Cash | See Part IV |
Nazareth Housing Inc13-3176952 | New York, NY | $25K | Cash | See Part IV |
New Day Foundations for Families26-0609040 | Rochester Hills, MI | $25K | Cash | See Part IV |
Northern Michigan University Foundation23-7034523 | Marquette, MI | $25K | Cash | See Part IV |
Palm Springs Friends of Philharmonic23-7369948 | Palm Desert, CA | $25K | Cash | See Part IV |
St Joan of Arc Foundation92-3563396 | Bettendorf, IA | $25K | Cash | See Part IV |
St Pius X Catholic Church35-0940397 | Granger, IN | $25K | Cash | See Part IV |
The Ireland Funds America25-1306992 | Boston, MA | $25K | Cash | See Part IV |
| Naples, FL | $25K | Cash | See Part IV | |
Women's Care Center Foundation38-3651599 | South Bend, IN | $25K | Cash | See Part IV |
Wayne State University38-6028429 | Detroit, MI | $25K | Cash | See Part IV |
Santa Clara University94-1156617 | Santa Clara, CA | $23.6K | Cash | See Part IV |
Mexican American Catholic College74-1712528 | San Antonio, TX | $22.5K | Cash | See Part IV |
Florida A&M University59-0977035 | Tallahassee, FL | $21.1K | Cash | See Part IV |
Healing Emergency Aid Response Team20-8583681 | Newark, NJ | $21K | Cash | See Part IV |
Archdiocese of Detroit38-1359274 | Detroit, MI | $20K | Cash | See Part IV |
C24 7 Fathers Arms Ministries81-3116501 | Chicago, IL | $20K | Cash | See Part IV |
Catholic Charities of Southern Nevada88-0059425 | Las Vegas, NV | $20K | Cash | See Part IV |
Christ House52-1362103 | Washington, DC | $20K | Cash | See Part IV |
House of Cherith Inc82-5393648 | Atlanta, GA | $20K | Cash | See Part IV |
INVANTI LLC82-2318356 | South Bend, IN | $20K | Cash | See Part IV |
Jenga Jumuiya27-3512967 | Houston, TX | $20K | Cash | See Part IV |
L'Arche Chicago36-4030812 | Forest Park, IL | $20K | Cash | See Part IV |
Margaret's Village36-3104655 | Chicago, IL | $20K | Cash | See Part IV |
Marian Center School and Services Inc65-0341008 | Miami Gardens, FL | $20K | Cash | See Part IV |
Martin Luther College41-0695520 | New Ulm, MN | $20K | Cash | See Part IV |
Northwest Detroit Youth Coalition38-3441362 | Detroit, MI | $20K | Cash | See Part IV |
St John the Evangelist Catholic School58-1097003 | Smyrna, GA | $20K | Cash | See Part IV |
Sweet Dream Makers81-3693206 | Boca Raton, FL | $20K | Cash | See Part IV |
Weascend Corporation20-8188786 | Atlanta, GA | $20K | Cash | See Part IV |
Winamac First United Methodist Church35-1173721 | Winamac, IN | $20K | Cash | See Part IV |
University of Tennessee62-6001636 | Knoxville, TN | $19.1K | Cash | See Part IV |
Gordon Research Conference26-0150662 | East Greenwich, RI | $19K | Cash | See Part IV |
Monell Chemical Senses Center23-2020897 | Philadelphia, PA | $19K | Cash | See Part IV |
Auburn University63-6000724 | Auburn, AL | $17.9K | Cash | See Part IV |
St Louis University43-0654872 | St Louis, MO | $17.5K | Cash | See Part IV |
National Defense Industrial Association53-0196547 | Arlington, VA | $17.5K | Cash | See Part IV |
South Bend Alumni Association35-1674506 | South Bend, IN | $17.5K | Cash | See Part IV |
Restoration Destination Inc83-1554251 | Pahokee, FL | $17.3K | Cash | See Part IV |
Metropolitan Family Service (MFS)93-0397825 | Portland, OR | $17K | Cash | See Part IV |
Food Bank of Northern Indiana35-1898055 | South Bend, IN | $17K | Cash | See Part IV |
St John's Seminary95-1642384 | Camarillo, CA | $16K | Cash | See Part IV |
CISE82-0977523 | Cincinnati, OH | $16K | Cash | See Part IV |
WNIT Public Television35-1155594 | South Bend, IN | $16K | Cash | See Part IV |
Pokagon Band of Potawatomi38-3278535 | South Bend, IN | $15.8K | Non-Cash | See Part IV |
Mishawaka Food Pantry Inc45-2297920 | Mishawaka, IN | $15.5K | Cash | See Part IV |
100 Women Strong27-1041148 | St Joseph, MI | $15K | Cash | See Part IV |
American Endowment Foundation34-1747398 | Hudson, OH | $15K | Cash | See Part IV |
Beyond Basics75-2993015 | Southfield, MI | $15K | Cash | See Part IV |
Catholic Charities West Michigan38-3012473 | Grand Rapids, MI | $15K | Cash | See Part IV |
Catholic Church Extension Society36-6000520 | Chicago, IL | $15K | Cash | See Part IV |
Humanitarian Distribution Center In20-5527985 | Francesville, IN | $15K | Cash | See Part IV |
Kewanna United Methodist Church35-1064234 | Kewanna, IN | $15K | Cash | See Part IV |
Kinetic Kids Inc74-3080076 | San Antonio, TX | $15K | Cash | See Part IV |
National Humanities Center59-1735367 | Durham, NC | $15K | Cash | See Part IV |
New City Kids22-3529691 | Grand Rapids, MI | $15K | Cash | See Part IV |
Our Lady of Grace Monastery35-1003229 | Beech Grove, IN | $15K | Cash | See Part IV |
Our Redeemer Lutheran Church35-1162691 | Knox, IN | $15K | Cash | See Part IV |
Place of Hope Inc65-0841384 | Palm Beach Gardens, FL | $15K | Cash | See Part IV |
Pulaski County Human Services Inc35-1829856 | Winamac, IN | $15K | Cash | See Part IV |
Royal Center United Methodist Church35-1890281 | Royal Center, IN | $15K | Cash | See Part IV |
St Ann School36-2284297 | Chicago, IL | $15K | Cash | See Part IV |
St Teresa of Avila Parish36-2171137 | Chicago, IL | $15K | Cash | See Part IV |
The Vines Foundation86-3200509 | Eastwood, KY | $15K | Cash | See Part IV |
California State University Channel Islands91-2153805 | Camarillo, CA | $14.5K | Cash | See Part IV |
National Football Foundation51-0226347 | Irving, TX | $14.4K | Cash | See Part IV |
Notre Dame Club of Chicago36-2385194 | Chicago, IL | $14K | Cash | See Part IV |
Mission of Our Lady of the Angels20-3436272 | Chicago, IL | $13K | Cash | See Part IV |
Women's Care Center35-1609945 | South Bend, IN | $13K | Cash | See Part IV |
Downtown South Bend Inc35-1546291 | South Bend, IN | $12.5K | Cash | See Part IV |
St Joseph County Parks & Rec Dept35-1459569 | South Bend, IN | $12.5K | Cash | See Part IV |
Unlock the Arts Inc88-1799848 | Portland, OR | $12.5K | Cash | See Part IV |
American Cancer Society13-1788491 | Atlanta, GA | $11.6K | Cash | See Part IV |
Latin American Studies Association52-0882881 | Pittsburgh, PA | $11.6K | Cash | See Part IV |
YWCA35-0868226 | South Bend, IN | $11.5K | Cash | See Part IV |
Center for the Performing Arts20-3901164 | Carmel, IN | $11.3K | Cash | See Part IV |
Venues Parks & Arts27-3843043 | South Bend, IN | $11K | Cash | See Part IV |
Widlife Care Clinic at Iowa State University42-6004224 | Ames, IA | $11K | Cash | See Part IV |
The History Museum35-1124156 | South Bend, IN | $10.5K | Cash | See Part IV |
Bighorn Golf Club Charities20-5377872 | Palm Desert, CA | $10K | Cash | See Part IV |
Boulder Cancer Fighters45-2675512 | Berthoud, CO | $10K | Cash | See Part IV |
| Davenport, IA | $10K | Cash | See Part IV | |
Community Services of Starke County35-1424216 | Knox, IN | $10K | Cash | See Part IV |
Conesus Fest for Charity Inc16-1439738 | Orchard Park, NY | $10K | Cash | See Part IV |
Corvilla Inc35-6062577 | South Bend, IN | $10K | Cash | See Part IV |
Empire Center for Public Policy Inc46-1987418 | Albany, NY | $10K | Cash | See Part IV |
Family & Children's Center35-0869031 | South Bend, IN | $10K | Cash | See Part IV |
First Christian Church35-1534330 | Francesville, IN | $10K | Cash | See Part IV |
Friends of the Juvenile Justice Center35-2097175 | South Bend, IN | $10K | Cash | See Part IV |
Give Kids The World Inc59-2654440 | Kissimmee, FL | $10K | Cash | See Part IV |
Habitat for Humanity of Greater Lowell04-3123186 | Westford, MA | $10K | Cash | See Part IV |
Immokalee Fair Housing Alliance83-3223257 | Immokalee, FL | $10K | Cash | See Part IV |
Leadership Council for Women in National Security87-2884514 | Washington, DC | $10K | Cash | See Part IV |
Life Choices Inc22-3703602 | Phillipsburg, NJ | $10K | Cash | See Part IV |
Martha's Vineyard Film Society Inc61-1476858 | Vineyard Haven, MA | $10K | Cash | See Part IV |
Meridian International Center53-0259663 | Washington, DC | $10K | Cash | See Part IV |
Neighbor To Neighbor Inc82-3646124 | South Bend, IN | $10K | Cash | See Part IV |
Northwestern Memorial Healthcare36-3155315 | Chicago, IL | $10K | Cash | See Part IV |
Part of the Solution (POTS)13-3425071 | Bronx, NY | $10K | Cash | See Part IV |
| Philadelphia, PA | $10K | Cash | See Part IV | |
Providence St Mel School36-2977187 | Chicago, IL | $10K | Cash | See Part IV |
Puente Desarrollo Internacional Inc82-4237540 | South Bend, IN | $10K | Cash | See Part IV |
Sacred Heart Cathedral42-6005490 | Davenport, IA | $10K | Cash | See Part IV |
Schwab Charitable Fund31-1640316 | San Francisco, CA | $10K | Cash | See Part IV |
Serenelli Project Inc85-3844890 | Cincinnati, OH | $10K | Cash | See Part IV |
SOME Inc (So Others Might Eat)23-7098123 | Washington, DC | $10K | Cash | See Part IV |
South Bend Civic Theatre35-1572312 | South Bend, IN | $10K | Cash | See Part IV |
St Clements Parish & School36-3158705 | Chicago, IL | $10K | Cash | See Part IV |
St John Berchmans Parish & School36-2171034 | Chicago, IL | $10K | Cash | See Part IV |
Stanley Clark School35-1019540 | South Bend, IN | $10K | Cash | See Part IV |
Star City United Methodist Church35-1526260 | Star City, IN | $10K | Cash | See Part IV |
United Way of Metropolitan Chicago30-0200478 | Chicago, IL | $10K | Cash | See Part IV |
United Way of St Joseph County35-1063368 | South Bend, IN | $10K | Cash | See Part IV |
University of Texas System30-0710145 | Austin, TX | $10K | Cash | See Part IV |
Valley Youth House Committee Inc23-7178820 | Bethlehem, PA | $10K | Cash | See Part IV |
Heisman Trophy Trust13-7052079 | New York, NY | $8,800 | Cash | See Part IV |
St Joseph County Right to Life35-1594988 | South Bend, IN | $8,400 | Cash | See Part IV |
Christ the King Catholic Church46-1748937 | Tampa, FL | $8,100 | Cash | See Part IV |
Big Shoulders Fund36-3490557 | Chicago, IL | $7,865 | Cash | See Part IV |
Reins of Life Inc31-0945572 | South Bend, IN | $7,750 | Cash | See Part IV |
FeedMore WNY Inc22-2470820 | Buffalo, NY | $7,500 | Cash | See Part IV |
La Casa de Amistad35-1350013 | South Bend, IN | $7,500 | Cash | See Part IV |
Youth Services Bureau31-1174910 | South Bend, IN | $7,500 | Cash | See Part IV |
ATA Engineering Inc33-0900801 | San Diego, CA | $7,492 | Cash | See Part IV |
University of California San Francisco94-6036493 | San Francisco, CA | $7,323 | Cash | See Part IV |
Greater Pittsburgh Community Food Bank25-1420599 | Duquesne, PA | $6,829 | Cash | See Part IV |
Wright State University31-0732831 | Dayton, OH | $6,346 | Cash | See Part IV |
YMCA38-1358236 | Niles, MI | $6,250 | Cash | See Part IV |
Habitat for Humanity31-1196894 | South Bend, IN | $6,025 | Cash | See Part IV |
Fellowship of Catholic University84-1522811 | Denver, CO | $6,000 | Cash | See Part IV |
National Catholic College Admission22-2811383 | New Albany, OH | $6,000 | Cash | See Part IV |
St Mary of Carmel Catholic School75-1248930 | Dallas, TX | $6,000 | Cash | See Part IV |
Howard University53-0204707 | Washington, DC | $5,906 | Cash | See Part IV |
South Bend Museum of Art35-0844563 | South Bend, IN | $5,750 | Cash | See Part IV |
St Margaret's House35-1913328 | South Bend, IN | $5,700 | Cash | See Part IV |
Lumen Christi Institute36-4191992 | Chicago, IL | $5,695 | Cash | See Part IV |
St Adalbert's School35-1095958 | South Bend, IN | $5,575 | Cash | See Part IV |
Community Foundation of Pulaski County35-2127564 | Winamac, IN | $5,500 | Cash | See Part IV |
Liberty Theater Preservation Allian47-5325421 | Lewiston, ID | $5,500 | Cash | See Part IV |
Youth Theater Northwest91-1261911 | Mercer Island, WA | $5,250 | Cash | See Part IV |
St Jude Children's Research Hospital62-0646012 | Memphis, TN | $5,100 | Cash | See Part IV |
| Total | $42M | |||
West Palm Beach, FL
$2.1M
University of California Berkeley
Berkeley, CA
$1.4M
South Bend, IN
$1.3M
Bethesda, MD
$1.2M
Detroit, MI
$1.1M
Baltimore, MD
$1M
Chicago, IL
$1M
Atlanta, GA
$976.2K
Urbana, IL
$965.6K
South Bend, IN
$852.6K
University of California Los Angeles
Los Angeles, CA
$771.1K
University of Utah
Salt Lake City, UT
$751.5K
West Lafayette, IN
$717.9K
Evanston, IL
$654K
Indiana University
Bloomington, IN
$653.3K
Warwick, RI
$600K
University of California San Diego
La Jolla, CA
$582.9K
California Institute of Technology
Pasadena, CA
$577.5K
Stanford University
Stanford, CA
$558.7K
Ithaca, NY
$543.7K
Lauderdale Lakes, FL
$500K
The Catholic Foundation
Dallas, TX
$500K
Pittsburgh, PA
$495.1K
Mathematica Policy Research
Princeton, NJ
$461.6K
Cambridge, MA
$443.3K
Charlottesville, VA
$421.9K
University of Minnesota
Minneapolis, MN
$413.5K
Durham, NC
$407.5K
University of Colorado
Denver, CO
$406.1K
Notre Dame, IN
$399.6K
Chapel Hill, NC
$366.8K
Notre Dame, IN
$333.1K
University of Texas Southwestern
Dallas, TX
$289.5K
Chestnut Hill, MA
$288.2K
Ann Arbor, MI
$252.4K
University of Iowa
Iowa City, IA
$251.1K
Intellectually Developmentally Disabled Community Foundation
Boca Raton, FL
$250K
Nuestra Senora De La Vivienda Community Foundation
Boca Raton, FL
$250K
Culver City, CA
$250K
Washington, DC
$239.3K
Iskali
Stone Park, IL
$227K
Nashville, TN
$225.2K
Florida International University
Miami, FL
$219.3K
Open Environmental Data Inc
Hudson, NY
$216.5K
Cultivate Food Rescue
South Bend, IN
$214K
Boston, MA
$209.8K
General Electric Corporation
Pittsburgh, PA
$208K
Montana State University
Bozeman, MT
$203.1K
University of Texas Dallas
Richardson, TX
$200.3K
Early Childhood Development Center
Notre Dame, IN
$200K
Eisenhower Medical Center
Rancho Mirage, CA
$200K
University of Maryland
College Park, MD
$198.2K
Clemson University
Clemson, SC
$195K
Rochester, NY
$194.2K
University of Arkansas
Little Rock, AR
$191.1K
Memphis, TN
$190.4K
Chicago, IL
$190.2K
Colorado State University
Fort Collins, CO
$190.1K
Southern Methodist University
Dallas, TX
$185.5K
Albany, NY
$185.2K
FGC Plasma Solutions Inc
Middleton, MA
$180.9K
Iowa State University
Ames, IA
$174.7K
South Bend, IN
$170.9K
Pittsburgh, PA
$168.1K
Washington State University
Pullman, WA
$161.2K
Boston, MA
$160K
Arizona State University
Tempe, AZ
$152.5K
Washington, DC
$145.6K
Space Tango
Lexington, KY
$140K
University of Puerto Rico Mayaguez
Mayaguez, PR
$130.5K
Orono, ME
$129.5K
Michiana Partnership Inc
South Bend, IN
$129.2K
Cleveland, OH
$127.6K
Oregon State University
Corvallis, OR
$126.9K
South Bend, IN
$125K
Pope Francis Center
Detroit, MI
$125K
Riverdale, NY
$123K
Greenville, NC
$120K
Sarasota, FL
$120K
Washington, DC
$116.8K
Friends of The Cultural Center Inc
Palm Desert, CA
$115.1K
Notre Dame, IN
$115K
Boston, MA
$113.9K
College of William and Mary
Williamsburg, VA
$113.7K
Chicago, IL
$113.3K
The HDF Group
Champaign, IL
$110.8K
Notre Dame, IN
$110K
University of Washington
Seattle, WA
$108K
Cincinnati, OH
$107.5K
Joan & Sanford I Weill Medical College
New York, NY
$107K
University of California Irvine
Irvine, CA
$106.9K
Center for Disease Control
Atlanta, GA
$105.9K
University of California Davis
Davis, CA
$103.6K
University Corporation for Atmospheric Research
Boulder, CO
$101.9K
Washington, DC
$100K
Alpharetta, GA
$100K
Washington, DC
$100K
New York, NY
$100K
Potomac, MD
$100K
Charlotte, NC
$100K
Branchville, NJ
$100K
St Mary Catholic Church
Pahokee, FL
$100K
New York, NY
$100K
Washington, DC
$100K
$100K
University of Wyoming
Laramie, WY
$91.4K
Monterey, CA
$87.4K
South Bend, IN
$85K
Paw Paw, MI
$80.2K
La Jolla, CA
$80K
Cambridge, MA
$78.2K
New Orleans, LA
$77.8K
Cleveland, OH
$76.4K
Catholic Education Foundation
Louisville, KY
$75K
Pompano Beach, FL
$75K
The Way Church of Tampa Bay
Tampa, FL
$75K
Villanova, PA
$75K
South Bend, IN
$73.5K
New Mexico State University
Las Cruces, NM
$70.4K
St Louis, MO
$70K
Hanover, NH
$69.2K
Onaway, MI
$67.5K
University of Texas at Austin
Austin, TX
$65.5K
Duality Technologies Inc
Hoboken, NJ
$65.1K
Miami, FL
$65K
South Bend, IN
$65K
Texas A&M Engineering Experiment Station
College Station, TX
$61.2K
Columbus, OH
$60.5K
Boyds, MD
$60K
Richmond, CA
$60K
Alice International Inc
Milford, NH
$59.2K
Aerojet Rocketdyne
Segundo, CA
$57.8K
Goshen, IN
$56.4K
Piscataway, NJ
$55.5K
Charlotte, NC
$55.1K
Mount St Mary's University
Los Angeles, CA
$55K
Morgantown, WV
$54.6K
New York, NY
$54K
Indianapolis, IN
$53K
Sarasota, FL
$50K
North Palm Beach, FL
$50K
Chicago, IL
$50K
New York, NY
$50K
Wixom, MI
$50K
Chicago, IL
$50K
Ann Arbor, MI
$50K
Topsham, ME
$50K
$50K
Belmont, MA
$50K
Coral Gables, FL
$50K
Downingtown, PA
$50K
St Patrick's Church
Malvern, PA
$50K
Honeywell International Inc
Phoenix, AZ
$49.8K
University of Southern California
Los Angeles, CA
$48.5K
Detroit, MI
$48K
Chicago, IL
$47.8K
Arlington, VA
$44.9K
University of Arizona
Tucson, AZ
$44.1K
Waltham, MA
$43.1K
Franciscan School of Theology
San Diego, CA
$41K
Catholic Charities of Dallas
Dallas, TX
$40K
Catholic Charities of Northern Nevada
Reno, NV
$40K
Chicago, IL
$40K
Long Grove, IL
$40K
Jupiter, FL
$40K
Boise, ID
$40K
Wilmette, IL
$40K
Naples, FL
$40K
Hillsdale, MI
$39K
Ayiti Analytics
Silver Spring, MD
$38.3K
Gainesville, FL
$37.6K
Rice University
Houston, TX
$36.3K
Boston, MA
$36K
Cambridge, MA
$35.9K
Lake Worth, TX
$35K
Evanston, IL
$35K
South Bend, IN
$35K
Needham, MA
$34.7K
South Bend, IN
$33.9K
South Dakota School of Mines and Technology
Pierre, SD
$33.7K
New York, NY
$33.7K
Mishawaka, IN
$30K
Boca Raton, FL
$30K
$30K
Fort Lauderdale, FL
$30K
Indianapolis, IN
$30K
Coconut Creek, FL
$30K
Indianapolis, IN
$30K
Washington, DC
$30K
Harbor Springs, MI
$30K
Oblate School of Theology
San Antonio, TX
$30K
Immokalee, FL
$30K
Detroit, MI
$30K
Ocoee, FL
$30K
St Martha Catholic Church
Porter, TX
$30K
St Nicholas Episcopal Church
Pompano Beach, FL
$30K
University of the Incarnate Word
San Antonio, TX
$30K
Michigan Technological University
Houghton, MI
$28.2K
Texas Biomedical Research Institute
San Antonio, TX
$26.1K
University of Texas at El Paso
El Paso, TX
$25.5K
Crest Hill, IL
$25.5K
University of Cincinnati
Cincinnati, OH
$25.3K
Sunrise, FL
$25.3K
ASSIA Inc
RDWC, CA
$25K
Boone, NC
$25K
Naples, FL
$25K
Brooklyn, NY
$25K
Independence, OH
$25K
Notre Dame, IN
$25K
Inspire Access Inc
Potomac, MD
$25K
La Puente Home Inc
Alamosa, CO
$25K
Montclair, NJ
$25K
Arlington, VA
$25K
Rochester, MN
$25K
Mercy Ships Foundation
Garden Valley, TX
$25K
Oxford, OH
$25K
Milwaukee, WI
$25K
New York, NY
$25K
Rochester Hills, MI
$25K
Marquette, MI
$25K
Palm Desert, CA
$25K
St Joan of Arc Foundation
Bettendorf, IA
$25K
St Pius X Catholic Church
Granger, IN
$25K
Boston, MA
$25K
$25K
South Bend, IN
$25K
Detroit, MI
$25K
Santa Clara University
Santa Clara, CA
$23.6K
Mexican American Catholic College
San Antonio, TX
$22.5K
Tallahassee, FL
$21.1K
Newark, NJ
$21K
Detroit, MI
$20K
C24 7 Fathers Arms Ministries
Chicago, IL
$20K
Catholic Charities of Southern Nevada
Las Vegas, NV
$20K
Washington, DC
$20K
House of Cherith Inc
Atlanta, GA
$20K
INVANTI LLC
South Bend, IN
$20K
Houston, TX
$20K
Forest Park, IL
$20K
Chicago, IL
$20K
Miami Gardens, FL
$20K
New Ulm, MN
$20K
Detroit, MI
$20K
Smyrna, GA
$20K
Sweet Dream Makers
Boca Raton, FL
$20K
Atlanta, GA
$20K
Winamac First United Methodist Church
Winamac, IN
$20K
University of Tennessee
Knoxville, TN
$19.1K
East Greenwich, RI
$19K
Philadelphia, PA
$19K
Auburn University
Auburn, AL
$17.9K
St Louis, MO
$17.5K
Arlington, VA
$17.5K
South Bend, IN
$17.5K
Restoration Destination Inc
Pahokee, FL
$17.3K
Metropolitan Family Service (MFS)
Portland, OR
$17K
South Bend, IN
$17K
St John's Seminary
Camarillo, CA
$16K
CISE
Cincinnati, OH
$16K
South Bend, IN
$16K
Pokagon Band of Potawatomi
South Bend, IN
$15.8K
Mishawaka, IN
$15.5K
St Joseph, MI
$15K
Hudson, OH
$15K
Beyond Basics
Southfield, MI
$15K
Grand Rapids, MI
$15K
Chicago, IL
$15K
Francesville, IN
$15K
Kewanna United Methodist Church
Kewanna, IN
$15K
Kinetic Kids Inc
San Antonio, TX
$15K
Durham, NC
$15K
Grand Rapids, MI
$15K
Beech Grove, IN
$15K
Knox, IN
$15K
Palm Beach Gardens, FL
$15K
Winamac, IN
$15K
Royal Center, IN
$15K
Chicago, IL
$15K
Chicago, IL
$15K
The Vines Foundation
Eastwood, KY
$15K
California State University Channel Islands
Camarillo, CA
$14.5K
Irving, TX
$14.4K
Chicago, IL
$14K
Chicago, IL
$13K
South Bend, IN
$13K
South Bend, IN
$12.5K
South Bend, IN
$12.5K
Unlock the Arts Inc
Portland, OR
$12.5K
Atlanta, GA
$11.6K
Pittsburgh, PA
$11.6K
South Bend, IN
$11.5K
Carmel, IN
$11.3K
South Bend, IN
$11K
Widlife Care Clinic at Iowa State University
Ames, IA
$11K
South Bend, IN
$10.5K
Palm Desert, CA
$10K
Berthoud, CO
$10K
Davenport, IA
$10K
$10K
Orchard Park, NY
$10K
South Bend, IN
$10K
Albany, NY
$10K
South Bend, IN
$10K
First Christian Church
Francesville, IN
$10K
South Bend, IN
$10K
Kissimmee, FL
$10K
Westford, MA
$10K
Immokalee Fair Housing Alliance
Immokalee, FL
$10K
Leadership Council for Women in National Security
Washington, DC
$10K
Phillipsburg, NJ
$10K
Vineyard Haven, MA
$10K
Washington, DC
$10K
Neighbor To Neighbor Inc
South Bend, IN
$10K
Chicago, IL
$10K
Bronx, NY
$10K
Philadelphia, PA
$10K
Chicago, IL
$10K
Puente Desarrollo Internacional Inc
South Bend, IN
$10K
Sacred Heart Cathedral
Davenport, IA
$10K
San Francisco, CA
$10K
Serenelli Project Inc
Cincinnati, OH
$10K
Washington, DC
$10K
South Bend, IN
$10K
Chicago, IL
$10K
Chicago, IL
$10K
South Bend, IN
$10K
Star City United Methodist Church
Star City, IN
$10K
Chicago, IL
$10K
South Bend, IN
$10K
University of Texas System
Austin, TX
$10K
Bethlehem, PA
$10K
New York, NY
$8,800
South Bend, IN
$8,400
Tampa, FL
$8,100
Chicago, IL
$7,865
South Bend, IN
$7,750
Buffalo, NY
$7,500
South Bend, IN
$7,500
South Bend, IN
$7,500
ATA Engineering Inc
San Diego, CA
$7,492
University of California San Francisco
San Francisco, CA
$7,323
Duquesne, PA
$6,829
Wright State University
Dayton, OH
$6,346
Niles, MI
$6,250
South Bend, IN
$6,025
Fellowship of Catholic University
Denver, CO
$6,000
New Albany, OH
$6,000
St Mary of Carmel Catholic School
Dallas, TX
$6,000
Washington, DC
$5,906
South Bend, IN
$5,750
South Bend, IN
$5,700
Chicago, IL
$5,695
St Adalbert's School
South Bend, IN
$5,575
Winamac, IN
$5,500
Lewiston, ID
$5,500
Youth Theater Northwest
Mercer Island, WA
$5,250
Memphis, TN
$5,100
Showing the first 500 records.
Source: USAspending.gov · Searched by organization name
VA/DoD Awards
$79.1M
VA/DoD Award Count
22
Funding from the Department of Veterans Affairs and/or Department of Defense.
Total Federal Funding (partial)
$848M
Awards Found
200+
Additional awards may exist. View all on USAspending.gov →
Department of Energy
$76.5M
RADIATION AND PHOTOCHEMISTRY IN THE CONDENSED PHASE AND AT INTERFACES
Department of Energy
$40.6M
TAS::89 0227::TAS RECOVERY; RECOVERY ACT - MATERIALS SCIENCE OF ACTINIDES -- EFRC; PI - PETER BURNS
Department of Energy
$32.8M
RAFIATION AND PHOTOCHEMISTRY IN THE CONDENSED PHASE
Agency for International Development
$31M
SUPPORTING HOLISTIC AND ACTIONABLE RESEARCH IN EDUCATION (SHARE)
National Science Foundation
$28.8M
SII-CENTER: SPECTRUMX ? AN NSF SPECTRUM INNOVATION CENTER
National Science Foundation
$19.4M
NSF CENTER FOR COMPUTER-ASSISTED SYNTHESIS -THE NSF CENTER FOR COMPUTER ASSISTED SYNTHESIS (CCAS) IS A NEXUS OF COLLABORATION, INNOVATION, AND EDUCATION THAT BRINGS TOGETHER DATA SCIENCE AND CHEMICAL SYNTHESIS. THE HIGHLY INTERDISCIPLINARY CCAS TEAM, COMPOSED OF SYNTHETIC ORGANIC CHEMISTS, COMPUTATIONAL CHEMISTS, AND COMPUTER SCIENTISTS, IS DEVELOPING DATA SCIENCE TOOLS AND COMPUTATIONAL WORKFLOWS THAT WILL LIKELY SHAPE THE FUTURE OF SYNTHETIC CHEMISTRY AND THE FIELDS IT ENABLES, SUCH AS MEDICINE, MATERIALS SCIENCE, AND ENERGY RESEARCH. THIS SITE?S IMPACTS ARE BEING FURTHER AMPLIFIED BY AN EXTENSIVE NETWORK OF ACADEMIC, INDUSTRIAL AND NON-PROFIT PARTNERS AND RESEARCH CENTERS, AND ITS DATA CHEMISTRY TOOLS ARE BEING SHARED WITH THE RESEARCH COMMUNITY THROUGH OPEN-SOURCE CLEARINGHOUSES. ALL OF THIS PROVIDES CCAS WITH A UNIQUE OPPORTUNITY TO DEVELOP, EXCHANGE, AND EVALUATE IDEAS IN THE FIELD OF DATA CHEMISTRY, AND ITS SHARED TOOLS AND TRAINING WILL EMPOWER STUDENTS, PRACTICING CHEMISTS, AND THE CHEMICAL INDUSTRY TO EFFECTIVELY APPLY DATA SCIENCE TO THEIR OWN CHEMICAL RESEARCH. LED BY ORGANIC CHEMISTS AT EVERY STAGE, CCAS FOCUSES ON USE-INSPIRED DATA SCIENCE RESEARCH THAT DRIVES THE DEVELOPMENT OF NEW DATA TYPES AND MACHINE LEARNING (ML) METHODS THAT ENABLE THE DISCOVERY OF NOVEL REACTIONS AND YIELD NEW SCIENTIFIC INSIGHTS. THE FOUR SCIENTIFIC THRUSTS INCLUDE (I) DEVELOPING EFFECTIVE ML TOOLS FOR OPTIMIZING CHEMICAL REACTIONS, (II) GAINING MECHANISTIC UNDERSTANDING THROUGH INTERPRETABLE STATISTICAL MODELS AND ELECTRONIC STRUCTURE CALCULATIONS, (III) PREDICTING REACTION OUTCOMES TO ANTICIPATE AND DISCOVER NEW REACTIVITY AND (IV) INTEGRATING THESE TOOLS FOR THE EFFICIENT PLANNING AND EXECUTION OF MULTISTEP SYNTHESES OF COMPLEX MOLECULES. TO ACCOMPLISH THESE GOALS, THREE THEMES ARE INTERWOVEN INTO EACH OF THE THRUSTS: (A) NEW STRUCTURED DATA TYPES THAT ARE AMENABLE TO HIGH-THROUGHPUT EXPERIMENTATION AND PREDICTIVE MODELS FROM THE GROUND UP, GOING BEYOND THE INFORMATION FROM COMMONLY USED DATABASES, (B) MOLECULAR AND REACTION REPRESENTATIONS THAT BRIDGE DESCRIPTOR-BASED AND STRUCTURE-BASED DEEP LEARNING PARADIGMS, AND (C) ALGORITHMS SPECIFICALLY DESIGNED FOR THE LOW DATA REGIMES PREVALENT THROUGHOUT CHEMISTRY. THROUGH THESE INTEGRATED RESEARCH THEMES AND THRUSTS, CCAS CONSTRUCTS AND SHARES DATA CHEMISTRY PLATFORMS THAT ARE EXPECTED TO ENABLE CHEMISTS TO TACKLE AMBITIOUS CHALLENGES THAT THE FIELD IS CURRENTLY UNDER-EQUIPPED TO PURSUE. THE DATA CHEMISTRY PLATFORM ALSO WILL OPEN UP NEW OPPORTUNITIES IN UNDERGRADUATE AND GRADUATE EDUCATION, AND THROUGH PARTNERSHIPS WITH THE DATA CHEMISTS NETWORK AND RESEARCH OPPORTUNITIES FOR CHEMISTS WITH DISABILITIES, CCAS SEEKS TO BROADEN THE PARTICIPATION OF RESEARCHERS FROM UNDERREPRESENTED GROUPS. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.
Department of Health and Human Services
$16.8M
HARNESSING THE POWER OF EXPERIMENTAL GENETIC CROSSES AND SYSTEMS GENETICS TO PROBE DRUG RESISTANCE IN MALARIA
National Science Foundation
$13.1M
PFC: JOINT INSTITUTE FOR NUCLEAR ASTROPHYSICS, JINA
Department of Energy
$13M
UNIVERSITY OF NOTRE DAME SSAA PROGRAM: ''ACTINIDE CENTER OF EXCELLENCE'' MOD 0000 INCREMENTALLY FUNDS BUDGET PERIOD 1.
Agency for International Development
$11.1M
MERLIN - EXPANDING THE REACH OF IMPACT EVALUATION
National Science Foundation
$11.1M
WOU-MMA: NUCLEAR PHYSICS AT THE NOTRE DAME NUCLEAR SCIENCE LABORATORY PROVIDING A WINDOW ON THE UNIVERSE -THIS AWARD CONTINUES THE RESEARCH PROGRAM OF EIGHT FACULTY MEMBERS AND THEIR STUDENTS IN NUCLEAR STRUCTURE PHYSICS AND NUCLEAR ASTROPHYSICS AT THE UNIVERSITY OF NOTRE DAME. THE PROGRAM FOCUSES ON DIRECT MEASUREMENTS OF NUCLEAR REACTION AND DECAY PROCESSES THAT DETERMINE THE LIFE OF STARS, THE ORIGIN OF THE ELEMENTS, AND PRODUCTION OF MULTI MESSENGERS THAT PROVIDE A WINDOW ON THE UNIVERSE. THIS PROGRAM ADDRESSES KEY NUCLEAR PROCESSES THAT DEFINE THE TIMESCALES OF STELLAR EVOLUTION AND EXPLOSION PROCESSES. ANOTHER COMPONENT IS THE STUDY OF LOW ENERGY FUSION REACTIONS DURING THE LAST DAYS OF A STELLAR LIFE PRIOR TO SUPERNOVA EXPLOSION. THE PROGRAM ALSO EXPLORES THE NUCLEAR STRUCTURE EFFECTS THAT ARE GUIDING LARGE SCALE NUCLEOSYNTHESIS PROCESSES. THE RESEARCH IS PERFORMED PRIMARILY BY USING THE ACCELERATORS OF THE NUCLEAR SCIENCE LABORATORY (NSL) AT THE UNIVERSITY OF NOTRE DAME, WHICH ARE UNIQUELY DESIGNED TO PROBE STELLAR REACTIONS THROUGH A NUMBER OF EXPERIMENTAL TECHNIQUES. THE EXPERIMENTAL RESULTS EXPAND OUR KNOWLEDGE OF THE FUNDAMENTAL STRUCTURE OF THE NUCLEUS AS A MULTI-BODY QUANTUM SYSTEM; THEY ALSO PROVIDE NEW INSIGHT FOR THE ASTROPHYSICS COMMUNITY ON THE ORIGIN OF THE ELEMENTS AND THE CHEMICAL EVOLUTION OF THE COSMOS FROM THE BIG BANG TO THE PRESENT. THE NSL IS UNIQUELY EQUIPPED FOR PERFORMING THIS KIND OF RESEARCH IN A UNIVERSITY ENVIRONMENT. THE AWARD WILL SUPPORT THE TRAINING OF A LARGE NUMBER OF GRADUATE (APPROXIMATELY 25) AND UNDERGRADUATE STUDENTS (APPROXIMATELY 20) IN EXPERIMENTAL AND THEORETICAL TECHNIQUES TO BE READY TO JOIN THE NUCLEAR WORKFORCE OF THE NATION. THE EXPERIMENTAL PROGRAM IS BASED ON THE USE OF TWO ACCELERATORS AT THE NSL. INTENSE STABLE ION BEAMS FROM THE SINGLE ENDED 5U PELLETRON ARE USED FOR THE DIRECT STUDY OF LOW-ENERGY CAPTURE AND FUSION REACTIONS. HEAVY ION BEAMS ARE USED TO INVESTIGATE SUCH REACTIONS IN INVERSE KINEMATIC TECHNIQUE USING THE ST. GEORGE RECOIL SEPARATOR. THIS SEPARATOR IS UNIQUE AND SERVES AS A BLUEPRINT FOR THE DESIGN OF THE SECAR SEPARATOR AT FRIB. THE FN TANDEM ACCELERATOR IS USED AS A MULTI-PURPOSE INSTRUMENT. IT IS OPERATED AS A DRIVER FOR THE PRODUCTION OF RADIOACTIVE BEAMS AT THE NEWLY-EXPANDED TRISOL FACILITY, THE NATION'S FIRST DEDICATED INSTRUMENT FOR PRODUCING LOW ENERGY RADIOACTIVE BEAMS. THESE BEAMS ALLOW DIRECT REACTION MEASUREMENTS WITH AND THE TRAPPING OF LIGHT RADIOACTIVE PARTICLES AT LEVELS NOT POSSIBLE AT LARGE NATIONAL FACILITIES. THE FN ALSO SERVES THE ACCELERATOR MASS SPECTROMETRY (AMS) PROGRAM AT THE NSL, TESTING GEOLOGICAL AND COSMOLOGICAL SAMPLES FOR LONG-LIVED RADIOACTIVITIES. A LARGE NUMBER OF NUCLEAR STRUCTURE EXPERIMENTS ARE BASED ON THE OPERATION OF THIS MACHINE USING A VARIETY OF PARTICLE AND GAMMA SPECTROSCOPY TECHNIQUES. A SMALLER FRACTION OF THE PROGRAM RELIES ON THE USE OF OTHER NATIONAL AND INTERNATIONAL FACILITIES TO TAKE ADVANTAGE OF HIGHER ENERGY AND MORE EXOTIC BEAMS NOT AVAILABLE AT THE NSL. THIS PROJECT ADVANCES THE OBJECTIVES OF WINDOWS ON THE UNIVERSE: THE ERA OF MULTI-MESSENGER ASTROPHYSICS, ONE OF THE 10 BIG IDEAS FOR FUTURE NSF INVESTMENTS. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.
Department of Energy
$10.7M
CENTER FOR SHOCK WAVE-PROCESSING OF ADVANCED REACTIVE MATERIALS (C-SWARM)
Agency for International Development
$9.1M
STRONG BEGINNINGS: LEVERAGING THE HOME, SCHOOL, AND CHURCH TO DEVELOP THE WHOLE CHILD IN HAITI.
National Science Foundation
$8.4M
WOU-MMA: NUCLEAR PHYSICS AT THE NOTRE DAME NUCLEAR SCIENCE LABORATORY PROVIDING A WINDOW ON THE UNIVERSE
Department of Defense
$7.5M
FATIMA: FOG AND TURBULENCE INTERACTIONS IN THE MARINE ATMOSPHERE
Department of Defense
$7.3M
MOUNTAIN TERRAIN ATMOSPHERIC MODELING AND OBSERVATIONS (MATERHORN)PROGRAM
Department of Health and Human Services
$6.8M
INDUCIBLE ANTIBIOTIC RESISTANCE IN METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS
National Science Foundation
$6.6M
NUCLEAR STRUCTURE AND NUCLEAR ASTROPHYSICS
National Science Foundation
$6.5M
GRADUATE RESEARCH FELLOWSHIP PROGRAM (GRFP)
National Science Foundation
$6.4M
NUCLEAR STRUCTURE AND NUCLEAR ASTROPHYSICS
Agency for International Development
$6.3M
READ HAITI: SCALING EARLY GRADE READING IMPROVEMENT IN HAITI
Department of Defense
$6.3M
III-N DEVICES AND ARCHITECTURES FOR TERAHERTZ ELECTRONICS
National Science Foundation
$5.9M
NUCLEAR STRUCTURE AND NUCLEAR ASTROPHYSICS
Department of Energy
$5.4M
TAS::89 0336::TAS RECOVERY GLOBAL WARMING POTENTIAL (GWP) OF CURRENT REFRIGERANTS IS MORE THAN 1000 TIMES THE GWP OF CO2. THIS MAKES CO2 VERY ATTR
National Aeronautics and Space Administration
$5.3M
21-ULI STEP-B-0052 A SAFETY-AWARE ECOSYSTEM OF INTERCONNECTED AND REPUTABLE SUAS
Department of Energy
$5.1M
TAS::89 0336::TAS RECOVERY A RECENT DISCOVERY BY NOTRE DAME HAS IDENTIFIED A CLASS OF IONIC LIQUID MATERIALS WHICH UNDERGO A PHASE TRANSITION FROM
Department of Health and Human Services
$5M
NOVEL OXADIAZOLS FOR THE TREATMENT OF DRUG-RESISTANT GRAM-POSITIVE BACTERIA
Department of Energy
$4.9M
NUCLEAR PROPERTIES AT EXTREME DENSITY, TEMPERATURE, SPIN AND ISOSPIN
Agency for International Development
$4.8M
BROAD AGENCY ANNOUNCEMENT (BAA) UNDER THE MEDIA LITERACY FOR NEW DIGITAL ARRIVALS
National Science Foundation
$4.8M
GRADUATE RESEARCH FELLOWSHIP PROGRAM (GRFP) -THE NATIONAL SCIENCE FOUNDATION (NSF) GRADUATE RESEARCH FELLOWSHIP PROGRAM (GRFP) IS A HIGHLY COMPETITIVE, FEDERAL FELLOWSHIP PROGRAM. GRFP HELPS ENSURE THE VITALITY AND DIVERSITY OF THE SCIENTIFIC AND ENGINEERING WORKFORCE OF THE UNITED STATES. THE PROGRAM RECOGNIZES AND SUPPORTS OUTSTANDING GRADUATE STUDENTS WHO ARE PURSUING RESEARCH-BASED MASTER'S AND DOCTORAL DEGREES IN SCIENCE, TECHNOLOGY, ENGINEERING, AND MATHEMATICS (STEM) AND IN STEM EDUCATION. THE GRFP PROVIDES THREE YEARS OF FINANCIAL SUPPORT FOR THE GRADUATE EDUCATION OF INDIVIDUALS WHO HAVE DEMONSTRATED THEIR POTENTIAL FOR SIGNIFICANT RESEARCH ACHIEVEMENTS IN STEM AND STEM EDUCATION. THIS AWARD SUPPORTS THE NSF GRADUATE FELLOWS PURSUING GRADUATE EDUCATION AT THIS GRFP INSTITUTION. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.
Department of Defense
$4.8M
"(HEL-MRI FY07) AIRBORNE AERO-OPTICS LABORATORY (AAOL)"
National Science Foundation
$4.7M
NUCLEAR STRUCTURE AND NUCLEAR ASTROPHYSICS
Department of Transportation
$4.6M
THE PURPOSE OF THIS AWARD IS TO INITIATE A LOW FORCE FRICTION WELDING PROJECT SUBMITTED BY THE UNIVERSITY OF NOTRE DAME IN COLLABORATION WITH MANUFACTURING TECHNOLOGY, INC. (MTI). THE PROJECT GOAL IS TO DEMONSTRATE THE SUPERIOR JOINT PERFORMANCE OF THE LOW FORCE FRICTION WELDING TECHNOLOGY, AS COMPARED TO CURRENT THERMITE AND EFB WELDING TECHNOLOGIES, WHEN APPLIED TO CONTINUOUSLY WELDED 136LB AREMA RAIL. THE PROJECT OBJECTIVES ARE TO 1) EVALUATE THE CURRENT STATE OF THE ART IN RAIL WELDING, 2) CONDUCT A FEASIBILITY STUDY OF LOW FORCE FRICTION WELDING USING PRISMATIC COUPONS, 3) STUDY THE PERFORMANCE OF LOW FORCE FRICTION WELDING ON 60LB AREMA RAIL USING AN EXISTING MACHINE AT MTI, 4) DESIGN, BUILD, AND RUN-OFF A LOW FORCE FRICTION WELDING MACHINE CAPABLE OF FABRICATING 136LB AREMA RAIL, 5) STUDY THE PERFORMANCE OF LOW FORCE FRICTION WELDING ON 136LB AREMA RAIL USING THIS NEW MACHINE, AND 6) DISSEMINATE KNOWLEDGE OF LOW FORCE FRICTION WELDING TO THE FRA TRANSPORTATION TECHNOLOGY CENTER TO POTENTIALLY INITIATE AN IN-TRACK TESTING IN A PHASE AFTER THE END OF THIS GRANTS PERIOD OF PERFORMANCE. THE RAIL COMMUNITY AT-LARGE WILL BENEFIT FROM THIS PROJECT.
Department of Defense
$4.6M
(R)-ND-336 FOR THE TREATMENT OF DIABETIC FOOT ULCERS
Department of Health and Human Services
$4.4M
DECODING THE REGULATION OF PROTEIN FOLDING BY SYNONYMOUS CODON USAGE - PROJECT SUMMARY - DECODING THE REGULATION OF PROTEIN FOLDING BY SYNONYMOUS CODON USAGE SYNONYMOUS MUTATIONS ARE WIDESPREAD IN COMPLEX, POLYGENIC DISEASES BUT ARE TYPICALLY REGARDED AS PHENOTYPICALLY SILENT, AS THEY PRESERVE THE AMINO ACID SEQUENCE OF THE ENCODED PROTEIN. YET, SYNONYMOUS MUTATIONS CAN SIGNIFICANTLY PERTURB PROTEIN HOMEOSTASIS THROUGH A VARIETY OF MECHANISMS, INCLUDING PERTURBING THE FOLDING MECHANISM OF THE ENCODED PROTEIN. RECENTLY, MY LAB DISCOVERED THAT SYNONYMOUS CODON-INDUCED CHANGES TO PROTEIN FOLDING CAN BE LARGE ENOUGH TO (A) EXCEED THE PROTEIN HOMEOSTATIC BUFFERING PROVIDED BY MOLECULAR CHAPERONES AND (B) LEAD TO A DRAMATIC TWO-FOLD DECREASE IN CELL GROWTH RATE. FOR THESE PROTEINS, CHANGING THE CODON USAGE PATTERN PRODUCES A FOLDED PROTEIN WITH AN ALTERED STRUCTURE, WHICH LEADS TO CHANGES IN ACTIVITY AND/OR SUSCEPTIBILITY TO DEGRADATION BY CELLULAR PROTEASES. THE PROFOUND IMPLICATION OF THESE RESULTS IS THAT CODON USAGE REPRESENTS ANOTHER LEVEL OF INFORMATION ENCODED WITHIN GENOMES, LINKING TOGETHER “SILENT” GENETIC DIFFERENCES WITH PROPER PROTEIN FUNCTION AND REGULATION OF A POTENTIALLY BROAD RANGE OF CELLULAR MECHANISMS. HISTORICALLY, HOWEVER, STUDYING PERTURBATIONS TO PROTEIN FOLDING MECHANISMS IN VIVO HAS PRESENTED IMMENSE TECHNICAL CHALLENGES. FOR THIS REASON, TO DATE ONLY A FEW EXAMPLES HAVE BEEN IDENTIFIED OF CONNECTIONS BETWEEN CODON USAGE AND PROTEIN FOLDING. AS A RESULT, WE LACK A COMPREHENSIVE PICTURE OF THE EXTENT TO WHICH SYNONYMOUS CODON USAGE CONTRIBUTES TO THE PRODUCTION OF A FUNCTIONAL PROTEOME AND HOW SYNONYMOUS MUTATIONS PERTURB PROTEIN HOMEOSTASIS. THIS PIONEER AWARD PROJECT IS DESIGNED TO BREAK THROUGH EXISTING TECHNICAL CHALLENGES, DEVELOPING A NOVEL APPROACH TO (I) BROADLY MEASURE FOR THE FIRST TIME THE NUMBER AND TYPES OF PROTEINS WITH FOLDING MECHANISMS SENSITIVE TO SYNONYMOUS CODON USAGE, ACROSS AN ENTIRE PROTEOME AND (II) DEEPLY INTERROGATE WHICH CODON USAGE PATTERNS AND FEATURES BEST SUPPORT PROPER PROTEIN FOLDING IN VIVO. THE AMBITIOUS, OVERARCHING GOAL OF THIS PROJECT IS TO ENABLE A NEXT GENERATION OF GENOMIC INFERENCE BY DEVELOPING A PREDICTIVE UNDERSTANDING OF THE SYNONYMOUS CODON USAGE PATTERNS THAT BEST SUPPORT PRODUCTION OF A FUNCTIONAL PROTEOME AND THE DYSREGULATION THAT LEADS TO HUMAN GENETIC DISEASE.
Department of Health and Human Services
$4.4M
NOTRE DAME STUDY OF RESILIENCY IN LATER LIFE
Department of Health and Human Services
$4.2M
CHARACTERIZATION OF BIOFILMS BY CORRELATED MASS SPECTROMETRIC AND RAMAN IMAGING
Department of Defense
$4.2M
TAS::57 3600::TAS "AIRBORNE AERO-OPTICS LABORATORY-TRANSONIC (AAOL-T)" DATED, 01 FEB 2012 AND REVISED BUDGET 14 SEP 2012"
Department of Health and Human Services
$4.2M
PLASMINOGEN AND PLASMIN: STRUCTURE AND FUNCTION
Department of Health and Human Services
$4.1M
DESIGN, SYNTHESES AND STUDIES OF NOVEL ANTITUBERCULOSIS AGENTS
Department of Education
$4M
INTEGRATING CIVIL DISCOURSE INTO THE CURRICULUM AT PUBLIC, PRIVATE, COMMUNITY AND HISTORICALLY MINORITY-SERVING COLLEGES AND UNIVERSITIES
Department of Health and Human Services
$4M
HIGH CAPACITY PROTEIN PURIFICATION FOR STRUCTURAL IMMUNOLOGY
Department of Health and Human Services
$3.9M
MOLECULAR PROBES FOR BIOMEMBRANE RECOGNITION
Department of Defense
$3.8M
BIOLOGICALLY-INSPIRED CNN IMAGE PROCESSORS WITH DYNAMICALLY-INTEGRATED HYPERSPECTRAL NANOSCALE SENSORS
Department of Health and Human Services
$3.8M
BUILDING BETTER T CELL RECEPTORS FOR TARGETED IMMUNOTHERAPY
Department of Health and Human Services
$3.8M
ROLE OF N-ALPHA ACETYLATION IN MYCOBACTERIAL SECRETION AND VIRULENCE
Department of Health and Human Services
$3.7M
REPURPOSING GRAM-POSITIVE ANTIBIOTICS FOR GRAM-NEGATIVE BACTERIA USING ANTIBIOTIC ADJUVANTS - MULTI-DRUG RESISTANT (MDR) ACINETOBACTER BAUMANNII INFECTIONS PRESENT AN ENORMOUS ONGOING CHALLENGE TO PUBLIC HEALTH. DUE TO THE FREQUENT OCCURRENCE OF MULTIDRUG RESISTANCE, CURRENT TREATMENT OPTIONS FOR A. BAUMANNII INFECTIONS ARE LIMITED. SS-LACTAM ANTIBIOTICS, ESPECIALLY CARBAPENEMS, REPRESENT THE TREATMENT OF CHOICE FOR SUSCEPTIBLE INFECTIONS. HOWEVER, CARBAPENEM RESISTANCE IS INCREASINGLY COMMON, AND FOR SUCH INFECTIONS THERE IS NO CONSENSUS ON THE OPTIMAL ALTERNATIVE TREATMENT. BECAUSE RESISTANCE HAS HITHERTO BEEN RELATIVELY UNCOMMON, COLISTIN HAS BECOME A FAVORED TREATMENT IN SPITE OF THE FACT THAT DELETERIOUS SIDE EFFECTS ARE COMMON. HOWEVER, RESISTANCE TO COLISTIN IN A. BAUMANNII IS BECOMING MORE FREQUENT WITH THE RECENT DISSEMINATION OF PLASMID-BORNE COLISTIN RESISTANCE GENES (MCR-1-10) INTO HEALTHCARE FACILITIES. UNFORTUNATELY, THE RECENT TRACK RECORD OF DISCOVERY OF NEW ANTIBIOTICS THAT ARE ACTIVE AGAINST GRAM-NEGATIVE BACTERIA IS EXCEEDINGLY POOR, WHICH, COUPLED WITH THE EXIT OF BIG PHARMA FROM ANTIBIOTIC DISCOVERY, HAS MADE THE DEVELOPMENT OF NEW THERAPIES AND NON-TRADITIONAL THERAPEUTIC APPROACHES VITAL. TO COMBAT THIS GROWING THREAT, WE INITIATED A RESEARCH PROGRAM TO IDENTIFY SMALL MOLECULES, TERMED ANTIBIOTIC ADJUVANTS, THAT POTENTIATE THE ACTIVITY OF MACROLIDES AGAINST MDR A. BAUMANNII. TO THIS END, WE HAVE SUCCESSFULLY IDENTIFIED MOLECULES THAT LOWER THE MINIMUM INHIBITORY CONCENTRATION (MIC) OF CLARITHROMYCIN UP TO 512-FOLD AGAINST ALL MEMBERS OF A PANEL OF PRIMARY CLINICAL A. BAUMANNII ISOLATES FROM THE WALTER REED ARMY INSTITUTE OF RESEARCH (WRAIR) THAT ENCOMPASSES NEARLY ALL CLINICALLY RELEVANT A. BAUMANNII CLADES. ADJUVANTS ALSO POTENTIATE THE ACTIVITY OF VANCOMYCIN UP TO 256-FOLD. BOTH MACROLIDES AND VANCOMYCIN ARE TYPICALLY VIEWED AS “GRAM-POSITIVE” SELECTIVE ANTIBIOTICS DUE TO THEIR INABILITY TO CROSS THE OUTER MEMBRANE OF GRAM-NEGATIVE BACTERIA, MECHANISTIC STUDIES HAVE LED TO A WORKING HYPOTHESIS THAT THESE COMPOUNDS OVERCOME THIS BARRIER BY INCREASING PERMEABILITY OF THE OUTER MEMBRANE THROUGH INHIBITING LIPOOLIGOSACCHARIDE (LOS) PRODUCTION. COMBINATIONS OF ADJUVANT WITH CLARITHROMYCIN ARE EFFECTIVE IN A GALLERIA MELLONELLA MODEL OF INFECTION, WHICH HAS BEEN SHOWN TO PREDICT OUTCOME IN MURINE MODELS OF INFECTION IN THE CONTEXT OF MDR A. BAUMANNII. THEREFORE, COMBINATIONS OF SUCH ADJUVANTS WITH EITHER CLARITHROMYCIN OR VANCOMYCIN MAY FORM THE BASIS FOR AN EFFICACIOUS APPROACH TO TREATING MDR A. BAUMANNII INFECTIONS FOR WHICH THERE ARE NO EFFECTIVE ANTIBIOTICS.
Department of Health and Human Services
$3.7M
INTERACTIONS REGULATING TRANSLATION AND PROTEIN BIOGENESIS IN VIVO
National Science Foundation
$3.5M
GRADUATE RESEARCH FELLOWSHIP PROGRAM (GRFP)
Department of Health and Human Services
$3.5M
RECEPTOR CROSS-TALK IN EARLY METASTATIC DISSEMINATION
Department of Defense
$3.5M
MURI SASCWATCH: STUDY ON AIR-SEA COUPLING WITH WAVES, TURBULENCE, AND CLOUDS AT HIGH WINDS 23-000005369
Department of State
$3.4M
TO MAXIMIZE IMPLEMENTATION OF COLOMBIA'S PEACE ACCORD AND IMPROVE THE LIKELIHOOD FOR SUSTAINABLE PEACE.
Department of Health and Human Services
$3.4M
PENICILLIN-BINDING PROTEINS, MECHANISM AND INHIBITION
Department of Health and Human Services
$3.3M
CHEMISTRY-BIOCHEMISTRY-BIOLOGY INTERFACE TRAINING PROGRAM AT NOTRE DAME
Department of Defense
$3.3M
MASTERS AND STEM PROGRAMS IN HYPERSONIC SYSTEMS
National Science Foundation
$3.3M
RESEARCH WITH THE CMS DETECTOR AT THE LHC -PARTICLE PHYSICS FOCUSES ON UNDERSTANDING THE MOST BASIC BUILDING BLOCKS OF NATURE AND THE RULES THAT BIND THEM. THE CERN LARGE HADRON COLLIDER (LHC), LOCATED NEAR GENEVA, SWITZERLAND IS THE WORLD'S MOST POWERFUL PARTICLE ACCELERATOR, ABLE TO REACH THE HIGHEST PARTICLE ENERGIES IN A LABORATORY SETTING. THE CMS DETECTOR AT THE LHC IS A POWERFUL AND SOPHISTICATED CAMERA, OBSERVING THE COLLISIONS OF PROTONS AND RECORDING THE BYPRODUCTS FOR DETAILED STUDY BY CMS EXPERIMENTALISTS. ONE OF THEIR PRIMARY OBJECTIVES WAS TO FIND THE HIGGS BOSON, THE LAST PARTICLE IN THE HISTORICALLY SUCCESSFUL STANDARD MODEL (SM) THAT ACCOUNTS FOR SO MUCH OF THE EXISTENCE OF, AND FORCES BETWEEN, KNOWN PARTICLES FORMING THE MATTER IN THE UNIVERSE. THIS EFFORT HAS BEEN SUCCESSFUL. THE NEXT STEP IN THE EXPERIMENTS IS TO LOOK FOR EVIDENCE FOR PHYSICS BEYOND THE STANDARD MODEL (BSM) THAT MIGHT, FOR INSTANCE, ACCOUNT FOR THE PRESENCE OF THE MYSTERIOUS DARK MATTER THAT MAKES UP SO MUCH OF THE MASS OF THE UNIVERSE. THE LHC IS CURRENTLY IN THE ONSET OF RUN 3 WITH SIGNIFICANTLY INCREASED EVENT SAMPLES. IT IS POSSIBLE THAT EVIDENCE FOR BSM PHYSICS COULD EMERGE AT THIS HIGHER ENERGY AND WITH THE HIGHER EVENT STATISTICS. THROUGH THIS PROJECT, THE HIGH ENERGY PHYSICS GROUP AT NOTRE DAME UNIVERSITY WILL MAXIMIZE THE DISCOVERY POTENTIAL OF THE CMS EXPERIMENT THROUGH CONTRIBUTIONS TO DATA ANALYSIS, PREPARATIONS AND OPERATIONS FOR THE NEXT LHC RUN AS WELL AS DATA ANALYSIS AND MAJOR CONTRIBUTIONS TO THE HIGH LUMINOSITY UPGRADES OF THE LHC. THE NEXT THREE YEARS WILL BE A CHALLENGING PERIOD AS THE CMS EXPERIMENT PRESSES FORWARD ON THREE SEPARATE FRONTS: CONTINUING THE ANALYSIS OF THE DATA COLLECTED DURING THE PAST RUN, PREPARING FOR AND THEN BEGINNING TO ANALYZE TWICE AS MUCH DATA FROM THE UPCOMING RUN, AND BEGINNING THE CONSTRUCTION FOR THE HIGH LUMINOSITY LHC UPGRADES. NOTRE DAME ACTIVITIES INCLUDE CONTRIBUTIONS ACROSS SEVERAL AREAS OF THE CMS DETECTOR INCLUDING THE ELECTROMAGNETIC CALORIMETER, THE HADRONIC CALORIMETER, TRIGGER, COMPUTING, AND OFFLINE SOFTWARE. THEIR PHYSICS ANALYSIS PLANS LEVERAGE PAST INVESTMENTS IN HIGGS AND TOP QUARK PHYSICS, WHILE ALSO ESTABLISHING NEW DIRECTIONS FOR DIRECTLY AND INDIRECTLY PROBING FOR NEW PHYSICS. THE NOTRE DAME GROUP WILL CONTINUE TO LEVERAGE THEIR EXPERTISE IN CALORIMETRY IN SEVERAL HIGGS ANALYSES AND SEARCHES FOR NEW PHENOMENA, INCLUDING HIGGS DECAYS TO TWO TAU LEPTONS, TWO PHOTONS, OR A MUON LEPTON AND A TAU LEPTON. ADDITIONALLY, THEY WILL EXPLOIT THEIR CONTRIBUTIONS TO THE PHASE 1 UPGRADES OF CMS CALORIMETRY FOR IMPROVED PERFORMANCE DURING THE NEXT LHC RUN. THEY WILL ALSO CONTINUE TO COORDINATE AND MANAGE THE OPTICAL READOUT AND DECODING FOR ENDCAP AND BARREL HADRON CALORIMETRY. THE GROUP HAVE LEADERSHIP ROLES IN HIGH-LUMINOSITY LHC UPGRADE PROJECTS, INCLUDING THE ELECTROMAGNETIC AND HADRONIC BARREL CALORIMETER UPGRADES, THE ENDCAP CALORIMETER UPGRADE, AND THE ADDITION OF A NEW TIMING LAYER DETECTOR FOR CMS. THIS PROJECT ALSO INCLUDES CONTRIBUTIONS TO THE LEVEL 1 TRACK TRIGGER UPGRADE AND CONTINUING CONTRIBUTIONS TO HIGH LEVEL TRIGGER OPERATIONS, OFFLINE AND COMPUTING, AND DATA PRESERVATION. THE GROUP WILL ENGAGE BROADLY IN EDUCATION AND OUTREACH THROUGH QUARKNET AND MANY OTHER PUBLIC-FACING INITIATIVES. NOTRE DAME IS LEAD AND THE MANAGING INSTITUTION OF QUARKNET, WHICH CURRENTLY CONSISTS OF 52 CENTERS IN 25 STATES AND PUERTO RICO AND HAS BEEN EXPANDED TO INCLUDE EXPERIMENTAL PROGRAMS AT NATIONAL AND FOREIGN LABORATORIES. THEIR OUTREACH EFFORTS INCLUDE DEVELOPMENT AND IMPLEMENTATION OF ELECTRONIC LABORATORIES (E-LABS) FOR LHC DATA AND COSMIC RAY DATA, MASTERCLASSES BASED ON PARTICLE PHYSICS AND ASTROPHYSICS, AND PARTICIPATION IN PROGRAMS THAT SUPPORT SUMMER RESEARCH FOR UNDERGRADUATES, HIGH SCHOOL TEACHERS AND HIGH SCHOOL STUDENTS. THROUGH THESE EFFORTS, THEY CONTINUE TO DEVELOP AND BUILD UPON A SUITE OF OUTREACH MATERIALS AND DEMONSTRATION PROJECTS THAT BRING PARTICLE PHYSICS TO THE PUBLIC ON A NUMBER OF LEVELS, FROM REAL PHYSICS ANALYSIS ON LHC HIGGS DATA IN THE CLASSROOM TO A PARTICLE DETECTOR DISPLAY AT THE SMITHSONIAN. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.
Department of Health and Human Services
$3.2M
DESIGNING SELECTIVE INHIBITORS OF IGE-MEDIATED MAST CELL DEGRANULATION
National Science Foundation
$3.1M
RESEARCH WITH THE CMS DETECTOR AT THE LHC
Department of Health and Human Services
$3.1M
RESISTANCE TO CARBAPENEM ANTIBIOTICS IN ACINETOBACTER BAUMANNII
Department of Health and Human Services
$3.1M
CARBAPENEMASE-STABLE CARBAPENEM ANTIBIOTICS FOR TREATMENT OF MULTIDRUG-RESISTANT ACINETOBACTER BAUMANNII INFECTIONS - ACINETOBACTER BAUMANNII IS LISTED BY THE CDC AS A CLINICAL PATHOGEN THAT POSES A SERIOUS ANTIBIOTIC RESISTANCE THREAT IN THE UNITED STATES, DUE TO ITS RESISTANCE TO THE LAST RESORT CARBAPENEM ANTIBIOTICS (CARBAPENEM-RESISTANT A. BAUMANNII OR CRAB), WHICH WERE THE DRUGS OF CHOICE FOR TREATMENT OF INFECTIONS CAUSED BY THIS MICROORGANISM. IN ADDITION, CRAB IS OFTEN RESISTANT TO ANTIMICROBIAL AGENTS OF DIFFERENT CLASSES (MULTI-DRUG-RESISTANT A. BAUMANNII OR MDRAB), WHICH SEVERELY LIMITS AVAILABLE THERAPEUTIC OPTIONS. THE MAJOR MECHANISM OF RESISTANCE OF A. BAUMANNII TO CARBAPENEMS IS PRODUCTION OF ANTIBIOTIC-INACTIVATING ENZYMES, CARBAPENEM-HYDROLYZING CLASS D SS- LACTAMASES OR CHDLS. IN ADDITION, CARBAPENEMASES OF CLASSES A AND B, SENSITIVITY OF CARBAPENEM TARGETS (BACTERIAL PENICILLIN-BINDING PROTEINS OR PBPS), RATES OF ANTIBIOTIC PENETRATION INTO THE BACTERIAL CELL AND THEIR EXPULSION BY EFFLUX PUMPS CAN ALSO CONTRIBUTE TO RESISTANCE. LEVELS OF RESISTANCE TO CARBAPENEMS REACH UP TO 90% IN SOME PARTS OF THE WORLD, AND MORTALITY RATES FROM INFECTIONS CAUSED BY SUCH BACTERIA ARE STAGGERINGLY HIGH, UP TO 50%. OUR LONG-TERM GOAL IS TO DEVELOP NOVEL ANTIBIOTICS FOR TREATMENT OF DEADLY MDRAB INFECTIONS. OVER THE LAST DECADE, THE VAKULENKO GROUP HAS PERFORMED IN-DEPTH CHARACTERIZATION OF CLINICALLY IMPORTANT CHDLS, WHICH PROVIDES GUIDANCE FOR DEVELOPMENT OF A NEW GENERATION OF CARBAPENEMS CAPABLE OF INHIBITING THESE ENZYMES. CONCURRENTLY, DR. JOHN BUYNAK’S (CO-PI) GROUP DEVELOPED DOZENS OF NOVEL ATYPICALLY-MODIFIED CARBAPENEM ANTIBIOTICS. WE EVALUATED THESE ANTIBIOTICS FOR THEIR ACTIVITY AGAINST MDRAB AND DEMONSTRATED THAT THREE OF THEM POSSESS SUPERIOR ACTIVITY (WHEN COMPARED TO COMMERCIAL CARBAPENEMS) AGAINST MDRAB. ALL THREE INHIBITED THE MOST PREVALENT A. BAUMANNII CHDL, OXA-23, AND HAD VARYING SPECTRA OF INHIBITORY ACTIVITY AGAINST OTHER CHDLS AND CARBAPENEMASES OF OTHER CLASSES. ONE OF THESE COMPOUNDS HAD AN UNPRECEDENTED WIDE SPECTRUM OF ACTIVITY AND RESISTED HYDROLYSIS BY A WIDE RANGE OF CLINICALLY IMPORTANT CARBAPENEMASES OF ALL MOLECULAR CLASSES. IN THIS GRANT APPLICATION, WE PROPOSE TO PERFORM DETAILED CHARACTERIZATION OF OUR NOVEL CARBAPENEM ANTIBIOTICS. WE WILL DETERMINE ACTIVITY OF OUR COMPOUNDS AGAINST A. BAUMANNII STRAINS EXPRESSING MAJOR CHDLS AND OTHER CARBAPENEMASES AND UNVEIL KINETIC AND STRUCTURAL FEATURES RESPONSIBLE FOR THEIR ABILITY TO INHIBIT THESE ENZYMES (AIM 1). WE WILL STUDY INTERACTION OF OUR NOVEL CARBAPENEMS WITH THEIR TARGETS, PBPS, AND DETERMINE TO WHAT EXTENT EFFLUX PUMPS AND PORINS INFLUENCE BACTERIAL RESISTANCE TO THESE ANTIBIOTICS (AIM 2). WE WILL DESIGN AND CHARACTERIZE SEVERAL DOZEN NOVEL CARBAPENEM ANTIBIOTICS TO FURTHER IMPROVE THEIR ANTIMICROBIAL ACTIVITY BY ENHANCING THEIR INHIBITORY POTENCY AGAINST VARIOUS CARBAPENEMASES, IMPROVING AFFINITY FOR PBPS AND INCREASING PENETRATION RATES AND RESISTANCE TO EFFLUX (AIM 3). WE WILL PERFORM IN VITRO CHARACTERIZATION OF OUR BEST NOVEL CARBAPENEMS TO ASSESS THEIR SOLUBILITY, STABILITY AND TOXICITY. FINALLY, OUR BEST COMPOUNDS WILL BE EVALUATED IN ANIMAL STUDIES TO APPRECIATE THEIR POTENTIAL AS NOVEL THERAPEUTIC AGENTS AGAINST MDRAB (AIM 4).
Department of Health and Human Services
$3.1M
TRAFFICKING SIGNALS IN P. FALCIPARUM
Department of Health and Human Services
$3M
COMPARATIVE TRANSCRIPTOMIC AND EPIGENOMIC ANALYSES OF MULLER GLIA REPROGRAMMING
Department of Health and Human Services
$3M
THE QUINAZOLINONE CLASS OF ANTIBACTERIAL AGENTS
Department of Health and Human Services
$3M
MECHANISMS AND MANIPULATION OF FORCE DEPENDENT BEHAVIOR IN T CELL BIOLOGY - SUMMARY TCR RECOGNITION OF PEPTIDES BOUND AND PRESENTED BY MHC PROTEINS UNDERLIES CELLULAR IMMUNITY. TCR RECOGNITION OF PMHC IS MOST OFTEN VIEWED THROUGH THE LENS OF TRADITIONAL RECEPTOR-LIGAND THEORY, WHERE CELLULAR RESPONSES ARE PRESUMED TO BE GOVERNED BY SOLUTION BINDING AFFINITIES OR KINETICS. WHILE THIS IS OFTEN THE CASE, WORK OVER THE PAST SEVERAL YEARS HAS SHOWN THAT COMPLEXITIES FROM MECHANICAL FORCES EXERTED ON MEMBRANE BOUND TCR AND PMHC CAN PROFOUNDLY INFLUENCE T CELL SIGNALING. OF NOTABLE INTEREST ARE CATCH BONDS: FORCE DEPENDENT ENHANCEMENTS OF THE LIFETIMES OF TCR-PMHC COMPLEXES FORMED BETWEEN INTERACTING CELLS. CATCH BONDS CAN LEAD TO LARGE CHANGES IN SIGNALING OUTPUT AND CAN GREATLY ENHANCE T CELL SENSITIVITY. DEMONSTRATING THE IMPORTANCE OF MECHANICAL FORCES IN TUNING T CELL RESPONSES, LIGANDS THAT ARE RECOGNIZED WITH STRONG AFFINITY BUT FAIL TO RESULT IN CATCH BONDS YIELD ALTERED OR EVEN NO T CELL SIGNALING. FORCE-DEPENDENT BEHAVIOR HAS BEEN IMPLICATED IN A WIDE RANGE OF T CELL BIOLOGICAL PROCESSES, INCLUDING THYMIC EDUCATION, RESPONSES TO VIRAL OR TUMOR ANTIGENS, AND VIRAL ESCAPE. ALTHOUGH THE IMPORTANCE OF MECHANICAL FORCE IN TCR RECOGNITION HAS BEEN DEMONSTRATED, WE HAVE ONLY A RUDIMENTARY UNDERSTANDING OF HOW TCRS FORM CATCH OR REVERT TO SLIP BONDS. WE (PI EVAVOLD) HAVE HAD RECENT SUCCESS IN MANIPULATING TCR CATCH BONDS (PUBLISHED IN SCIENCE THIS YEAR) BUT THIS WAS ACHIEVED THROUGH SCREENING LIBRARIES AND WITHOUT AN UNDERSTANDING OF MECHANISM. WE THUS LACK PREDICTIVE MODELS FOR FORCE DEPENDENT BEHAVIOR IN TCRS AND IN TURN HOW THIS AFFECTS BIOLOGY, WHICH IN TURN IMPACTS OUR ABILITY TO PREDICT IMMUNOGENICITY, ASSESS THE CONSEQUENCES OF MUTATIONS, AND HINDERS OUR ABILITY TO UNDERSTAND T CELL SPECIFICITY. RECENTLY, HOWEVER, WE DEVELOPED A COMPREHENSIVE FRAMEWORK TO IDENTIFY, MANIPULATE, AND PREDICT FORCE DEPENDENT BEHAVIOR IN TCR-PMHC INTERACTIONS. UNLIKE PRIOR EFFORTS, OUR FRAMEWORK DIRECTLY ADDRESSES MECHANISM. HERE, WE WILL FURTHER DEVELOP, REFINE, AND APPLY OUR FRAMEWORK. OUR DRIVING HYPOTHESIS IS THAT VIEWING FORCE DEPENDENT BEHAVIOR THROUGH THE LENS OF ENERGY WILL PROVIDE THE MISSING MECHANISTIC DETAIL OF HOW AND WHY CATCH BONDS EMERGE IN TCRS, ALLOW THEIR RATIONAL PREDICTION AND MANIPULATION, AND PERMIT FORCE CONSIDERATIONS TO BE INCLUDED IN ASSESSMENTS OF T CELL RECOGNITION OF ANTIGEN. OUR THREE AIMS ARE TO 1) FURTHER DEVELOP OUR MECHANISTIC FRAMEWORK FOR FORCE DEPENDENT TCR BEHAVIOR; 2) EXPLAIN HOW CHANGES TO CATCH BONDS EMERGE FROM NATURAL VARIATIONS IN TCR INTERFACES AND HOW CATCH BONDS REGULATE T CELL BIOLOGY; AND 3) USE RATIONAL CATCH BOND ENGINEERING TO BETTER CONTROL VIRAL INFECTION IN MICE. OVERALL, THE WORK IN THIS PROPOSAL WILL ILLUMINATE THE OPAQUE MECHANISMS THAT UNDERLIE T CELL MECHANOBIOLOGY, PLACE CATCH BONDS ON A FORMAL MECHANISTIC FOOTING, AND PROVIDE THE MEANS TO PREDICT AND PRODUCTIVELY MANIPULATE TCR CATCH BONDS AND ULTIMATELY T CELL BIOLOGY.
Department of Defense
$3M
AIRBORNE AERO-OPTICS LABORATORY-BEAM CONTROL
Department of Health and Human Services
$3M
DEVELOPMENT OF ANTIBIOTIC ADJUVANTS FOR GRAM-NEGATIVE BACTERIA
Department of Health and Human Services
$3M
DIAPAUSE IN CULEX MOSQUITOES
Department of Health and Human Services
$2.9M
FOSTERING HEALTHY DEVELOPMENT AMONG MALTREATED PRESCHOOL-AGED CHILDREN
Department of Health and Human Services
$2.9M
NETHEALTH: MODELING THE CO-EVOLUTION OF SOCIAL NETWORKS AND HEALTH BEHAVIORS
Department of Energy
$2.9M
TAS::89 0222::TAS; NEW; METASTABLE VORTEX LATTICES-PROPERTIES AND APPLICATIONS; PI-MORTEN ESKILDSEN
National Science Foundation
$2.9M
RESEARCH WITH THE CMS DETECTOR AT THE LHC
National Science Foundation
$2.9M
E2CDA: TYPE I: EXTREMELY ENERGY EFFICIENT COLLECTIVE ELECTRONICS (EXCEL)
Department of Defense
$2.8M
AIR-SEA COUPLING IN MONSOON INTRASEASONAL OSCILLATIONS
Department of Health and Human Services
$2.8M
AMINOGLYCOSIDE RESISTANCE IN ENTEROCOCCI
Department of Health and Human Services
$2.8M
CHAPERONE THERAPEUTICS FOR THE TREATMENT OF DPN
Department of Health and Human Services
$2.8M
MECHANISMS OF ERYTHROCYTIC INFECTION & ANEMIA IN MALARIA
Department of Health and Human Services
$2.8M
DEVELOPING ANTI-VIRAL RIBOZYMES TO SUPPRESS ARBOVIRUSES IN TRANSGENIC MOSQUITOES
Department of Health and Human Services
$2.8M
AN EVIDENCE-BASED FAMILY SUPPORT PROGRAM FOR PARENTS AND CHILDREN IN PALESTINE: A THEORY-BASED INTERVENTION - PROJECT SUMMARY/ABSTRACT FEW EVIDENCE-BASED PROGRAMS EXIST TO SUPPORT CHILDREN AND FAMILIES AFFECTED BY SOCIOPOLITICAL CONFLICT, DESPITE DOCUMENTED EVIDENCE OF THEIR HEIGHTENED RISK FOR EMOTIONAL AND BEHAVIORAL ADJUSTMENT PROBLEMS ASSOCIATED WITH EXPOSURE TO CONFLICT AND VIOLENCE AT MULTIPLE LEVELS OF THE SOCIAL ECOLOGY (E.G., POLITICAL, COMMUNITY, AND FAMILY). THUS, A CRITICAL NEED EXISTS FOR AN EVIDENCE-BASED PROGRAM TO AMELIORATE THE IMPACT OF POLITICAL VIOLENCE ON THE OVERALL WELL-BEING OF CHILDREN AND FAMILIES. THE CURRENT STUDY WILL CONDUCT A RIGOROUS EVALUATION OF A THEORETICALLY-DRIVEN, FAMILY-BASED INTERVENTION PROGRAM IN PALESTINE, INCLUDING BOTH THE WEST BANK AND GAZA. FIRMLY GROUNDED IN THE CULTURAL CONTEXT OF PALESTINE BUT WITH BROAD IMPLICATIONS FOR INDIVIDUALS EXPOSED TO SOCIOPOLITICAL VIOLENCE, THE LONG-TERM GOAL OF THIS PROJECT IS TO PROVIDE A FAMILY-FOCUSED INTERVENTION PROGRAM (PROMOTING POSITIVE FAMILY FUTURES; PPFF) THAT MAY FACILITATE INDIVIDUALS’ SENSE OF SAFETY AND SUPPORT IN THE CONTEXT OF CHRONIC ADVERSITY. THE OBJECTIVE IS TO EVALUATE THIS INTERVENTION PROGRAM IN THE CONTEXT OF A RANDOMIZED CLINICAL TRIAL (RCT) IN THE WEST BANK AND GAZA (N=300). THE CENTRAL HYPOTHESIS IS THAT THE PROGRAM WILL HAVE DIRECT POSITIVE EFFECTS ON FAMILY CONFLICT, PARENT PSYCHOPATHOLOGY AND PARENTAL SECURITY IN THE FAMILY AS WELL AS ON ADOLESCENT EMOTIONAL SECURITY IN THE FAMILY, WITH CASCADING EFFECTS ON ADOLESCENT ADJUSTMENT. CONSISTENT WITH FAMILY SYSTEMS THEORY, WE FURTHER HYPOTHESIZE THAT TREATMENT EFFECTS ON PARENTS WILL MEDIATE ON THE EFFECTS OF THE TREATMENT ON ADOLESCENT ADJUSTMENT. THE RATIONALE IS THAT BOLSTERING RESILIENCE IN FAMILY SYSTEMS IS A KEY APPROACH TO PROMOTING POSITIVE FUNCTIONING IN FAMILIES EXPOSED TO CHRONIC VIOLENCE. THE HYPOTHESIS WILL BE EVALUATED WITH THREE SPECIFIC AIMS: 1) EVALUATE THE EFFICACY OF AN EVIDENCE-BASED FAMILY SUPPORT PROGRAM; 2) EXAMINE PROCESS MODELS OF TREATMENT CHANGE, AND 3) EXAMINE INTERRELATIONS BETWEEN PARENT AND CHILD FUNCTIONING. TO ACHIEVE THESE AIMS, THE STUDY WILL BE AN RCT EMPLOYING A LONGITUDINAL DESIGN (N=300) WITH MULTI-METHOD ASSESSMENTS AT BASELINE (T1), POST-TEST (T2), 6-MONTH FOLLOW-UP (T3) AND 12-MONTH FOLLOW-UP (T4). FAMILIES INCLUDED IN THE STUDY WILL BE EVENLY DIVIDED BETWEEN THE WEST BANK (N=150) AND GAZA STRIP (N=150). FAMILIES WILL BE RANDOMIZED INTO THE INTERVENTION CONDITION (PPFF) OR TREATMENT AS USUAL (TAU). EACH TERRITORY WILL HAVE AN IMPLEMENTING PARTNER, AND IMPLEMENTING PARTNERS AND INVESTIGATORS WILL WORK TOGETHER TO ENSURE THE STUDY PROCEDURES ARE IMPLEMENTED IN PARALLEL ACROSS SITES. DATA COLLECTION WILL BE CONDUCTED BY TRAINED RESEARCH STAFF FROM A THIRD-PARTY SURVEY AND POLICY RESEARCH ORGANIZATION. THE PROPOSAL SEEKS TO SHIFT CURRENT RESEARCH AND CLINICAL PARADIGMS IN THESE CONTEXTS BY EMPLOYING NOVEL THEORETICAL CONCEPTS, APPROACHES, AND METHODOLOGIES. THE CONTRIBUTION WILL BE SIGNIFICANT BY 1) FURTHER DEVELOPING NEW DIRECTIONS FOR EMPIRICALLY-BASED INTERVENTIONS IN THESE HIGH-RISK CONTEXTS, AND 2) ADVANCING A RELATIVELY BRIEF, COST-EFFECTIVE PROGRAM THAT CAN BE READILY IMPLEMENTED TO HELP CHILDREN AND FAMILIES EXPOSED TO CONTINUING CONFLICT IN PALESTINE, WITH THE POTENTIAL TO BE BROUGHT TO SCALE IN OTHER CONTEXTS.
Department of Energy
$2.7M
NEW COOPERATIVE AGREEMENT IONIC LIQUIDS: BREAKTHROUGH ABSORPTION TECHNOLOGY FOR POST COMBUSTION CO2 CAPTURE
Department of Defense
$2.7M
THE COOPERATIVE AGREEMENT SHALL BE PERFORMED IN ACCORDANCE WITH STATEMENT OF WORK (ATTACHMENT 2), ENTITLED "ADVANCED TECHNOLOGY BOOSTERS TO ENABLE LOW TEMPERATURE LOGIC TECHNOLOGY ON A CMOS PLATFORM.
Department of Defense
$2.7M
BIOMATERIALS AND FIXATION METHODS DEVELOPMENT FOR TRAUMATIC ORTHOPAEDIC INJURIES
National Science Foundation
$2.7M
NEW GK-12: THE NOTRE DAME EXTENDED RESEARCH COMMUNITY (NDERC)
Department of Health and Human Services
$2.7M
CHILDREN AND POLITICAL VIOLENCE IN NORTHERN IRELAND
Department of Health and Human Services
$2.7M
DESIGN/SYNTHESES/STUDIES/NOVEL ANTITUBERCULOSIS AGENTS
National Science Foundation
$2.6M
MRI: DEVELOPMENT OF THE GEMINI PLANET IMAGER UPGRADE
Department of Health and Human Services
$2.6M
A LIFE COURSE PERSPECTIVE ON THE EFFECTS OF CUMULATIVE EARLY ADVERSITY ON HEALTH
Department of Defense
$2.6M
LONG-COHERENCE HIGH-FIDELITY ELECTRON QUBITS ON QUANTUM SOLIDS
Department of Health and Human Services
$2.6M
ADAPTING A POINT OF USE TEST CARD, THE CHEMOPAD, FOR PROTECTING CHEMOTHERAPY DRUG QUALITY IN SUB-SAHARAN AFRICA - ADAPTING A POINT OF USE TEST CARD, THE CHEMOPAD, FOR PROTECTING CHEMOTHERAPY DRUG QUALITY IN SUB-SAHARAN AFRICA PROJECT SUMMARY/ABSTRACT GOAL: VALIDATE A NEW TECHNOLOGY FOR DETECTING BAD QUALITY CHEMOTHERAPY PRODUCTS AT THE POINT OF USE. MOTIVATION: CHEMOTHERAPY MEDICINES FORM THE BACKBONE OF AFFORDABLE CANCER TREATMENT IN LOW- AND MIDDLE- INCOME COUNTRIES (LMICS), YET LMICS OFTEN LACK TECHNICAL AND REGULATORY CAPACITY TO EVALUATE THE QUALITY OF CHEMOTHERAPY PRODUCTS. THERE IS CURRENTLY NO COMMERCIAL TECHNOLOGY TO SCREEN FOR BAD QUALITY CHEMOTHERAPY PRODUCTS AT THE POINT OF USE IN LMIC SETTINGS, AND THE DRUG REGULATORS IN ETHIOPIA, MALAWI, KENYA, AND CAMEROON DO NOT CONDUCT POST-MARKET SURVEILLANCE TESTING ON CHEMOTHERAPY PRODUCTS. ACTIVITIES: THE TECHNOLOGY THAT WILL BE VALIDATED, CALLED SPOTCHECK, CONSISTS OF AN INEXPENSIVE PAPER TEST CARD (THE CHEMOPAD) AND A CELL PHONE APP. WE WILL FIRST ADAPT THE CHEMOPAD TO SCREEN EIGHT TYPES OF INJECTABLE CHEMOTHERAPY DRUGS. THE PHONE APP’S NEURAL NETWORK WILL BE TRAINED TO IDENTIFY PRODUCTS THAT ARE FALSIFIED OR CONTAIN LESS THAN 65% OF THE STATED API CONTENT. CLINICAL, ACADEMIC, AND SUPPLY CHAIN PARTNERS IN ETHIOPIA, MALAWI, CAMEROON, AND KENYA WILL CONDUCT ANNUAL SITUATION AWARENESS AND QUALITY SURVEYS OF 320 CHEMOTHERAPY PRODUCTS PER YEAR; THE RESULTS WILL ENABLE A TEAM OF RESEARCHERS AT U. NORTH CAROLINA TO MODEL THE MARKETS FOR CHEMOTHERAPY PRODUCTS AND EVALUATE THE COST-EFFECTIVENESS OF THE SPOTCHECK SYSTEM. AFTER A TECHNICAL PERFORMANCE MILESTONE IS PASSED, WE WILL TAILOR THE CLINICAL VALIDATION OF SPOTCHECK TO SUIT THE LOCAL NEEDS, CLINICAL WORKFLOWS, AND REGULATORY CAPACITY IN EACH SITE. THE VALIDATION OF THE SPOTCHECK SYSTEM WILL PROCEED THROUGH A PLANNING AND ETHICAL APPROVAL MILESTONE (Y3 IN ETHIOPIA AND MALAWI AND Y4 IN KENYA AND CAMEROON) AND THREE CLINICAL PHASES: PROFICIENCY STUDY, CLINICAL VALIDATION, AND IMPLEMENTATION PILOT. PROFICIENCY TESTING WILL DEMONSTRATE THAT ONCOLOGY PHARMACISTS AND NURSES CAN USE SPOTCHECK WITH ACCURACY >85% TO DETECT SF PRODUCTS. CLINICAL VALIDATION WILL ESTABLISH WHETHER SPOTCHECK WORKS CORRECTLY IN A CLINICAL SETTING ON AUTHENTIC PRODUCTS, RATHER THAN PROFICIENCY SAMPLES. THE IMPLEMENTATION PILOT STUDY WILL PROBE SPOTCHECK’S ABILITY TO TEST THE DROPS LEFT OVER IN PRODUCT VIALS AFTER PATIENT TREATMENTS ARE PREPARED IN THE HOSPITAL; THIS METHOD OF USE WOULD ALLOW SUSTAINABLE IMPLEMENTATION OF SPOTCHECK IN MANY HOSPITALS AND CLINICS IN LOW-RESOURCE SETTINGS. TECHNOLOGY TRANSFER EFFORTS WILL EMPOWER LMIC PARTNERS TO PRODUCE THE CHEMOPAD LOCALLY AND INTEGRATE THE CELL PHONE APP INTO REGULATORY REPORTING SYSTEMS. IMPACT: THIS PROJECT WILL HELP TO FILL THE HUGE EVIDENCE GAP ABOUT THE QUALITY OF CHEMO DRUGS IN LMICS, MAKE IT HARDER FOR MANUFACTURERS AND DISTRIBUTORS TO SELL BAD QUALITY PRODUCTS, AND IMPROVE THE QUALITY OF PRODUCTS THAT ARE USED TO TREAT PATIENTS IN LMICS. 1
Department of Defense
$2.6M
BEST DATA COLLECTION VALIDATION AND RESEARCH
Department of Health and Human Services
$2.5M
A LIFE COURSE PERSPECTIVE ON GUT MICROBIOME AGING AND HEALTH IN A NON-HUMAN PRIMATE MODEL - PROJECT SUMMARY THE GUT MICROBIOME HAS REPEATEDLY BEEN LINKED TO MAJOR DISEASES OF AGING, INCLUDING FRAILTY, OSTEOPOROSIS, AND DIABETES. HOWEVER, AFTER MORE THAN A DECADE OF SEARCHING, THERE IS STILL NO CONSENSUS ON WHICH MICROBIAL SPECIES OR TAXONOMIC FEATURES PROVIDE RELIABLE HALLMARKS OF AGING IN ADULTS OR THE ELDERLY. DIFFERENT PEOPLE HARBOR DIFFERENT COLLECTIONS OF MICROBES WITH DENSITIES AND DYNAMICS THAT VARY CONSIDERABLY FROM ONE PERSON TO THE NEXT. THIS PERSONALIZATION ARISES, IN PART, BECAUSE A GIVEN MICROBE MAY PERFORM DIFFERENT FUNCTIONS IN DIFFERENT PEOPLE, AND EVEN IN THE SAME PERSON AT DIFFERENT TIMES. THIS VARIABILITY CONSTRAINS THE UTILITY OF MICROBIOME TAXA (E.G. SPECIES, PHYLA, BIODIVERSITY) TO MEASURE HEALTH AND HEALTHY AGING. OVERCOMING THIS HURDLE REQUIRES A SHIFT IN STRATEGY, AWAY FROM TAXONOMIC DATA AND TOWARDS DATA TYPES THAT REFLECT THE GUT MICROBIOME’S FUNCTIONAL CAPACITIES, INCLUDING THE MICROBIAL GENES AND METABOLIC PATHWAYS FOUND IN THE GUT MICROBIOME’S METAGENOME. DEVELOPING GUT MICROBIOME MARKERS OF HEALTHY AGING WILL ALSO REQUIRE PROSPECTIVE, LONGITUDINAL POPULATION-BASED RESEARCH. HOWEVER, WE LACK PROSPECTIVE DATA SETS THAT TRACK LONGITUDINAL CHANGES IN INDIVIDUAL GUT MICROBIOME FUNCTION AND HEALTH OUTCOMES ACROSS ADULTHOOD AND OLD AGE. OUR OBJECTIVES IN THIS PROPOSAL ARE TO USE A PROSPECTIVE, FULL LIFE COURSE, NONHUMAN PRIMATE MODEL TO: (I) IDENTIFY CHANGES IN THE MICROBIOME’S FUNCTIONAL CAPACITIES ACROSS THE LIFE COURSE; (II) TEST HOW SOCIAL AND ENVIRONMENTAL FACTORS AFFECT THE NATURE AND PACE OF MICROBIOME AGING; (III) TEST HOW TAXA-FUNCTION RELATIONSHIPS CHANGE AT DIFFERENT LIFE STAGES; AND (IV) LEARN WHICH MICROBIOME FEATURES PREDICT PHYSICAL/BEHAVIORAL AGING AND ALL-CAUSE MORTALITY. OUR SYSTEM, THE WELL-STUDIED AMBOSELI BABOON POPULATION IN KENYA, CAPTURES THE COMPLEXITY OF HUMAN BEHAVIORAL AND SOCIAL CONDITIONS BETTER THAN OTHER ANIMAL MODELS. WE HAVE ALREADY PROFILED GUT MICROBIAL TAXONOMIC COMPOSITION IN 17,277 FECAL SAMPLES COLLECTED OVER 14 YEARS FROM 501 BABOONS. THESE DATA REVEAL PERSONALIZED MICROBIOME DYNAMICS AND AGING TRAJECTORIES THAT ARE SHAPED BY INDIVIDUAL SOCIAL AND ENVIRONMENTAL CONDITIONS. WE PROPOSE TO EXPAND THIS DATA SET FOR 10 MORE YEARS TO INCLUDE 800 TOTAL INDIVIDUALS AND ANALYZE MICROBIOME FUNCTIONAL CAPACITY IN 12,000 SAMPLES. BY IDENTIFYING DRIVERS AND PATTERNS OF MICROBIOME FUNCTIONAL AGING, WE WILL IDENTIFY TARGETS FOR INTERVENTIONS AIMED AT BUILDING AND SUSTAINING HEALTHY AGING. OUR RESULTS WILL HELP HARNESS THE PROMISE OF THE GUT MICROBIOME TO PREDICT AND IMPROVE HUMAN HEALTH.
Department of Health and Human Services
$2.5M
DIAGONAL CAPILLARY ELECTROPHORESIS FOR PHOSPHORYLATION AND SIALYLATION ANALYSIS
Department of Energy
$2.5M
PROBING LOCAL, HYBRID PEROVSKITE PHOTOPHYSICS THROUGH SPATIALLY- AND TEMPORALLY-RESOLVED ABSORPTION/EMISSION MICROSCOPY
Department of Health and Human Services
$2.5M
LEVERAGING NONINVASIVE TRANSCUTANEOUS VAGUS NERVE STIMULATION AND SMARTPHONE TECHNOLOGY TO REDUCE SUICIDAL BEHAVIORS AND SUICIDE AMONG HIGHLY VULNERABLE ADOLESCENTS - PROJECT SUMMARY / ABSTRACT OVER THE PAST TWO DECADES, SUICIDE RATES HAVE INCREASED NEARLY 35% IN THE U.S., WITH UP- WARD TRENDS IN NEARLY ALL DEMOGRAPHIC GROUPS. FURTHER INCREASES HAVE OCCURRED SINCE THE COVID-19 PANDEMIC BEGAN. DESPITE AMBITIOUS GOALS FOR REDUCING SUICIDES AND SIGNIFICANT FED- ERAL AND PRIVATE INVESTMENT, SUICIDE RATES CONTINUE TO RISE UNABATED. TO DATE, THE PREDOMINANT APPROACH TO MITIGATING SUICIDE RISK IN THE U.S. IS SECONDARY PREVENTION. TYPICALLY, THESE PRO- GRAMS IDENTIFY RISK OF RECURRENCE AMONG THOSE WHO HAVE ALREADY ATTEMPTED SUICIDE AT LEAST ONCE. ALTHOUGH SECONDARY PREVENTION IS CRUCIAL, THE MAJORITY OF DEATHS BY SUICIDE OCCUR ON FIRST ATTEMPT. THUS, TARGETED PRIMARY PREVENTION EARLIER IN DEVELOPMENT IS ESSENTIAL. MOST CURRENT PRI- MARY PREVENTION PROGRAMS ARE INTENSIVE, EXPENSIVE, AND DELIVERED BY HIGHLY TRAINED MENTAL HEALTH PROVIDERS, WHO ARE IN SHORT SUPPLY. TRADITIONAL FACE-TO-FACE THERAPY IS ALSO UNAVAILABLE TO MANY WHO LIVE IN UNDERSERVED COMMUNITIES, AND DISLIKED BY ADOLESCENTS, WHO MUCH PREFER DIGI- TAL DELIVERY ON THEIR DEVICES. THIS HIGH-RISK, HIGH-REWARD PROPOSAL ADDRESSES THESE LIMITATIONS AND NEEDS. WE USE AN EXPERIMENTAL THERAPEUTICS APPROACH TO EVALUATE THE INDEPENDENT AND COMBINED EFFICACIES OF TWO UNCONVENTIONAL BUT SCALABLE INTERVENTIONS: TRANSCUTANEOUS VAGUS NERVE STIMULATION (TVNS) TO TARGET EMOTION DYSREGULATION, AND A PEER-SUPPORT SMARTPHONE APP TO COMBAT SOCIAL ISOLATION. THESE LOW-COST INTERVENTIONS, WHICH HOLD STRONG PROMISE BUT HAVE NOT BEEN USED BEFORE, CAN REACH LARGE NUMBERS OF ADOLESCENTS, WITH MUCH POTENTIAL TO REDUCE PRO- SPECTIVE SUICIDE RISK. WE WILL ENROLL 212 ADOLESCENTS, AGES 13-17 YEARS, WHO SHOW ELEVATIONS ON AT LEAST TWO PROMINENT RISK FACTORS FOR SUICIDE (E.G., SELF-INJURY, MALTREATMENT). USING A 2 × 2 DE- SIGN, ADOLESCENTS WILL BE ASSIGNED RANDOMLY TO RECEIVE 30 DAYS OF TREATMENT WITH (1) TVNS TO TAR- GET EMOTION DYSREGULATION, (2) A PEER-SUPPORT PHONE APP TO TARGET SOCIAL ISOLATION, (3) TVNS + A PEER-SUPPORT PHONE APP, OR (4) ENHANCED TREATMENT AS USUAL WITH MONITORING AND ACCESS TO RE- SOURCES. INTERVENTION EFFECTS ON MECHANISMS (EMOTION DYSREGULATION, SOCIAL ISOLATION) PROXIMAL EFFICACY SIGNALS (E.G., PHYSIOLOGICAL REACTIVITY, SELF-HARM) AND TARGET OUTCOMES (SUICIDAL IDEATION, SUICIDAL BEHAVIORS) WILL BE EVALUATED IMMEDIATELY POST-INTERVENTION AND AT ONE-YEAR FOLLOW-UP. TREATMENT DATA WILL BE MONITORED DAILY TO FINE-TUNE DOSING OF BOTH INTERVENTIONS. THIS TRANSFORMA- TIVE AND INNOVATIVE PROPOSAL TESTS TWO NOVEL, SCALABLE PREVENTIVE INTERVENTIONS DESIGNED TO “MEET ADOLESCENTS WHERE THEY ARE" BY USING DIGITAL TECHNOLOGIES TO ADDRESS CORE MECHANISMS OF SUICIDE RISK.
National Science Foundation
$2.5M
QUIC-TAQS: DETERMINISTICALLY PLACED NUCLEAR SPIN QUANTUM MEMORIES FOR ENTANGLEMENT DISTRIBUTION
National Science Foundation
$2.5M
IDENTIFYING LOCAL-TO-GLOBAL WIN-WIN SOLUTIONS FOR HUMAN HEALTH AND SUSTAINABILITY THROUGH INFECTIOUS DISEASE CONTROL
Department of Commerce
$2.5M
FORECASTING SPREAD AND BIOECONOMIC IMPACTS OF AQUATIC INVASIVE SPECIES FROM MULTIPLE PATHWAYS TO IMPROVE MANAGEMENT AND POLICY IN THE GREAT LAKES.
National Science Foundation
$2.5M
MRI: ACQUISITION OF AN ACCELERATOR FOR STELLAR NUCLEOSYNTHESIS MEASUREMENTS
Department of Health and Human Services
$2.4M
EFFECTS OF AGRICULTURAL EXPANSION AND INTENSIFICATION ON INFECTIONS
Department of Health and Human Services
$2.4M
EFFICACY OF FAMILY PROGRAMS FOR IMPROVING CHILD AND FAMILY HEALTH AND DEVELOPMENT.
Department of Health and Human Services
$2.4M
PHYSICAL BASIS FOR T CELL RECEPTOR BINDING AND ACTIVITY
National Science Foundation
$2.4M
DIANA, A NOVEL NUCLEAR ACCELERATOR LAB UNDERGROUND
Department of Health and Human Services
$2.4M
BULGECIN TEMPLATE FOR POTENTIATION OF BETA-LACTAM ANTIBIOTICS
Department of Health and Human Services
$2.4M
FUNCTIONAL GENOMICS OF INVERSION 2LA IN ANOPHELES GAMBIAE
Department of Health and Human Services
$2.3M
ROLES FOR INCREASED INTRACELLULAR PH AND HETEROGENEITY IN CA
Department of Health and Human Services
$2.3M
AN INTEGRATIVE APPROACH TO ELUCIDATE GLIAL DIVERSITY AND ITS ROLE IN BRAIN FUNCTIONALITY
Department of Health and Human Services
$2.3M
GOLD NANOCRYSTAL ANTIBIOTICS FOR THE TREATMENT OF MULTIDRUG-RESISTANT GRAM NEGATI
Department of Health and Human Services
$2.3M
PHARMACOLOGICAL BLOCKAGE OF XBP-1S EXPRESSION IN CANCER
Department of Health and Human Services
$2.3M
AN INTEGRATIVE SCIENCE APPROACH TO RESILIENCE: THE NOTRE DAME STUDY OF HEALTH & WELL-BEING
Department of Health and Human Services
$2.3M
3H-PYRAZOLO[4,3-F]QUINOLINE-CONTAINING COMPOUNDS AS SELECTIVE AND TUNABLE PROTEIN KINASE INHIBITORS - PROJECT SUMMARY: ACUTE MYELOID LEUKEMIA (AML) IS A DEVASTATING CANCER WITH LIMITED OPTIONS, DESPITE DECADES OF INTENSIVE SEARCHES FOR CURATIVE THERAPEUTICS. THE AVERAGE 5-YEAR SURVIVAL OF AML IS ABOUT 30% (FOR ALL PATIENTS) BUT FOR MOST ELDERLY PATIENTS OVER 60 YEARS, THE 2-YEAR SURVIVAL RATE IS LESS THAN 5%. ABOUT 30% OF AML PATIENTS HARBOR A MUTATED FLT3 KINASE AND THESE PATIENTS HAVE THE WORST OUTCOME. MIDOSTAURIN AND GILTERITINIB, FLT3 INHIBITORS WERE APPROVED IN 2017 AND 2018 RESPECTIVELY. CRENOLANIB ANOTHER FLT3 INHIBITOR IS IN ADVANCED PHASE III CLINICAL TRIALS, WHEREAS QUIZARTINIB WAS APPROVED IN JAPAN BUT FAILED TO GAIN FDA APPROVAL. HOWEVER PATIENTS ON ALL OF THE FOUR FLT3 INHIBITORS ULTIMATELY RELAPSE DUE TO SECONDARY MUTATIONS IN THE FLT3 KINASE (SUCH AS FLT3-ITD, D835 AND F691 MUTANTS) AND OTHER COMPENSATORY RESISTANCE MECHANISMS. BREAST CANCER HAS AN AVERAGE 5-YEAR SURVIVAL RATE IS 93% FOR STAGE I AND II BUT FOR A SMALL BUT SIGNIFICANT PERCENTAGE (15-20%) OF BREAST CANCER PATIENTS, WHO HARBOR HORMONE REFRACTORY CANCER (CALLED TRIPLE NEGATIVE BREAST CANCER, TNBC), THERE ARE FEW THERAPEUTIC OPTIONS. CLEARLY NEW THERAPEUTICS, WHICH ARE EFFECTIVE AGAINST AML AND TNBC CANCERS, ARE NEEDED. THE PIS HAVE IDENTIFIED NOVEL 3H-PYRAZOLO[4,3-F]QUINOLINE-BASED KINASE INHIBITORS, SYNTHESIZED IN ONLY A SINGLE FLASK OPERATION, THAT POTENTLY INHIBIT FLT3 AND/OR CDK2 OR CDK12/13 OR CDK18. THE SELECTIVITY FOR THESE KINASES DEPEND ON THE SUBSTITUTION PATTERN OF THE 3H-PYRAZOLO[4,3-F]QUINOLINE CORE. CDK12/13 AND CDK18 ARE INVOLVED IN THE CELL'S RESPONSE TO DNA DAMAGE AND THE INHIBITION OF THESE KINASES LEAD TO BRCANESS IN VARIOUS CANCERS, MAKING SUCH CANCERS SENSITIVE TO AGENTS THAT DAMAGE DNA OR INHIBIT DNA DAMAGE REPAIR, SUCH AS DOXORUBICIN OR PARP INHIBITORS RESPECTIVELY. THE OVERALL GOAL OF THIS PROJECT IS TO OPTIMIZE THESE INTERESTING NEW CLASS OF KINASE INHIBITORS FOR POSSIBLE TRANSLATION INTO AML AND BREAST THERAPEUTICS. IN AIM 1, SECOND-GENERATION 3H- PYRAZOLO[4,3-F]QUINOLINE-BASED COMPOUNDS, (FIRST-GENERATION COMPOUNDS HAVE ALREADY SHOWN IMPRESSIVE IN-VIVO EFFICACY AGAINST AML IN VIVO), WILL BE BIOCHEMICALLY CHARACTERIZED AND EVALUATED IN VIVO (AIM 3). ADDITIONALLY NEW CHEMISTRIES WILL BE USED TO MAKE THIRD-GENERATION 3H-PYRAZOLO[4,3-F]QUINOLINE-BASED KINASE INHIBITORS THAT HAVE BETTER DRUG-LIKE PROPERTIES. AIM 2 CHARACTERIZE HOW THESE NEW POTENT ANTI-PROLIFERATIVE COMPOUNDS AFFECT PROTEIN PHOSPHORYLATION IN CANCER CELLS AND TO DETERMINE THE POTENCIES OF THE COMPOUNDS AT KILLING VARIOUS AML CELL LINES, WHICH ARE RESISTANT TO CURRENT THERAPIES SUCH AS GILTERITINIB, AND TRIPLE NEGATIVE BREAST CANCER CELL LINES IN VITRO. IN AIMS 3, THE PIS WILL EVALUATE THE IN-VIVO EFFICACIES OF LEAD COMPOUNDS AGAINST AML AND BREAST TUMORS. PROJECT, NOVEL AGENTS AGAINST AML AND BREAST CANCER, WHICH INHIBIT TRADITIONAL FLT3 (AML) AS WELL AS CDK12/13 AND CDK18, WHICH ARE INTERESTING NEW CANCER TARGETS WITH NO APPROVED DRUGS THAT TARGET THEM.
Department of Health and Human Services
$2.3M
BLOOD COAGULATION PROTEIN-METAL ION-LIPID INTERACTIONS
Department of Health and Human Services
$2.3M
FAMILIES OF YOUTH WITH DEVELOPMENTAL DISABILITIES: A THEORY-BASED INTERVENTION
Department of Health and Human Services
$2.3M
ELUCIDATING AND BYPASSING MOLECULAR MECHANISMS THAT SUPPRESS MULLER GLIA-DEPENDENT REGENERATION OF CONES IN TWO ZEBRAFISH MODELS OF CHRONIC RETINAL DAMAGE - PROJECT SUMMARY: RETINAL DEGENERATIVE DISEASES ARE A MAJOR MEDICAL ISSUE FOR SOCIETY. ONE POTENTIALLY EXCITING APPROACH TO RESTORE VISION IS THE REGENERATION OF LOST RETINAL NEURONS FROM AN ENDOGENOUS POPULATION OF RETINAL CELLS, THE MÜLLER GLIA. WE ARE STUDYING THIS PROCESS IN ZEBRAFISH, WHICH UNLIKE MAMMALS, EXHIBITS A NATURAL MÜLLER GLIA- DEPENDENT RETINAL REGENERATION RESPONSE. HOWEVER, THERE ARE TWO MAJOR GAPS IN OUR UNDERSTANDING OF THIS RETINAL REGENERATION RESPONSE. THE FIRST IS WHY RAPID ACUTE DAMAGE EXHIBITS A REGENERATION RESPONSE AND A SLOW CHRONIC DAMAGE, WHICH IS WHAT IS OFTEN OBSERVED IN HUMAN RETINAL DEGENERATIVE DISEASES, DOES NOT INDUCE A REGENERATION RESPONSE IN ZEBRAFISH. THE SECOND GAP IN OUR UNDERSTANDING IS THE ROLE OF THE MICROGLIA, THE IMMUNE CELLS OF THE CENTRAL NERVOUS SYSTEM, WHICH ARE THE MAJOR SOURCE OF INFLAMMATION RESULTING FROM DAMAGE AND A KNOWN REGULATOR OF THE MÜLLER GLIA-DEPENDENT RETINAL REGENERATION. WE WILL ADDRESS THESE TWO GAPS IN THREE SPECIFIC AIMS. AIM 1 WILL DETERMINE THE POTENTIAL OF TWO DIFFERENT CHRONIC ZEBRAFISH RETINAL DEGENERATION MUTANTS (GOSH, AN EARLY ONSET RAPID CONE PHOTORECEPTOR DEGENERATION MUTANT AND CEP290, A LATE ONSET SLOW CONE DEGENERATION MUTANT) TO INDUCE MÜLLER GLIA PROLIFERATION AND REGENERATE LOST CONES USING DIFFERENT STIMULI. WE WILL DETERMINE TO WHAT EXTENT EITHER A SECONDARY ACUTE DAMAGE OR THE INTRODUCTION OF MOLECULES THAT STIMULATE MÜLLER GLIA PROLIFERATION CAN INDUCE CONE REGENERATION IN CHRONICALLY DAMAGED FISH AND HOW COMPLETE THE REGENERATION PROCESS IS. IN AIM 2, WE WILL CONDUCT A COMPREHENSIVE AND UNBIASED, COMPARATIVE ANALYSIS OF GENE EXPRESSION AND CHROMATIN ACCESSIBILITY IN MÜLLER GLIA AND MICROGLIA USING A MULTIOMIC SINGLE-NUCLEAR RNA- SEQ AND ATAC-SEQ ANALYSIS IN THESE TWO CHRONIC DEGENERATION MUTANTS, ALONG WITH TWO MOUSE CHRONIC RETINAL DEGENERATION MUTANTS. WE WILL DETERMINE THE SIMILARITIES AND DIFFERENCES IN GENE EXPRESSION AND CHROMATIN ACCESSIBILITY IN THE MÜLLER GLIA AND MICROGLIA BETWEEN THE ACUTELY AND CHRONICALLY DAMAGED RETINAS. THESE BIOINFORMATIC ANALYSES WILL REVEAL TRANSCRIPTION FACTORS AND SIGNALING (CYTOKINE, GROWTH FACTORS, LIGAND/ RECEPTOR PAIRS) MOLECULES THAT ARE ESSENTIAL FOR REGENERATION FOLLOWING ACUTE DAMAGE AND BLOCKING REGENERATION IN THE CHRONICALLY DAMAGED ZEBRAFISH RETINA. WE WILL ALSO DETERMINE THE DIFFERENCES AND SIMILARITIES BETWEEN THE CHRONICALLY DAMAGED ZEBRAFISH AND MOUSE RETINAS TO DETERMINE HOW SIMILAR THESE REGULATORY COMPONENTS ARE BETWEEN THE ZEBRAFISH AND MOUSE. AIM 3 WILL THEN FUNCTIONALLY TEST THE ROLES OF THE CANDIDATE REGULATORS PREVIOUSLY IDENTIFIED IN OUR SCRNA-SEQ DATASETS OR IN AIM 2 BY EITHER MODIFYING THEIR EXPRESSION OR THEIR ACTIVITY IN THE CHRONICALLY AND ACUTELY DAMAGED ZEBRAFISH RETINA. THIS WORK WILL BE THE FIRST MOLECULAR ANALYSIS OF HOW RETINAL REGENERATION IS REGULATED IN THE CHRONICALLY DAMAGED ZEBRAFISH RETINA AND WILL BE CRITICAL IN THE TRANSLATION OF MÜLLER GLIAL-DEPENDENT RETINAL REGENERATIVE THERAPIES INTO HUMAN RETINAL DEGENERATIVE DISEASES.
Department of Health and Human Services
$2.3M
IDENTIFICATION OF KIDNEY REGENERATION MECHANISMS USING THE ZEBRAFISH
Department of Health and Human Services
$2.3M
DESIGN AND USE OF NOVEL BACTERIOCINS
Department of Health and Human Services
$2.2M
PATHWAYS LINKING EARLY ADVERSITY AND SUPPORT TO BEHAVIORAL AND PHYSICAL HEALTH
Department of Defense
$2.2M
AIRBORNE AERO-OPTICS LABORATORY - TRANSONIC (AAOL-T)
Department of Health and Human Services
$2.2M
DETERMINATION OF STRUCTURE, DYNAMICS AND ENERGETICS OF ENZYME REACTIONS
National Science Foundation
$2.1M
JOINT INSTITUTE FOR NUCLEAR ASTROPHYSICS - JINA
Department of Health and Human Services
$2.1M
EFFECTIVENESS OF AN EMPIRICALLY SUPPORTED FAMILY INTERVENTION: MENTAL HEALTH OUTCOMES, MECHANISMS OF EFFECT, AND ORGANIZATIONAL FACTORS - PROJECT SUMMARY/ABSTRACT COST-EFFECTIVE, BRIEF PROGRAMS TO SUPPORT FAMILY COMMUNICATION AND IMPROVE MENTAL HEALTH IN YOUTH ARE A PRESSING NEED; YET FEW EVIDENCE-BASED PROGRAMS EXIST. OUR GROUP HAS DEVELOPED AND RIGOROUSLY TESTED AN EMPIRICALLY-SUPPORTED FAMILY-SYSTEMS APPROACH TO IMPROVING COMMUNICATION AND CONFLICT IN FAMILIES, THEREBY IMPROVING MENTAL HEALTH IN YOUTH. BENEFICIAL EFFECTS FOR YOUTH MENTAL HEALTH AND OTHER INDICES OF ADJUSTMENT ASSOCIATED WITH THE HAPPY FAMILIES CURRICULUM HAVE BEEN SUPPORTED IN SEVERAL EFFICACY TRIALS WITH FAMILIES FROM A VARIETY RISK CONTEXTS. HOWEVER, THE VALUE OF EFFICACY RESEARCH IS LIMITED UNLESS IT IS SUBSEQUENTLY TESTED IN THE CONTEXT OF AN EFFECTIVENESS TRIAL. GIVEN THE POTENTIAL LARGE-SCALE BENEFITS OF BROAD IMPLEMENTATION OF THE HAPPY FAMILIES CURRICULUM, A CRITICAL NEED EXISTS FOR AN EFFECTIVENESS TRIAL TO EVALUATE THE PROGRAM WHEN IT IS IMPLEMENTED IN COMMUNITY SETTINGS BY FACILITATORS WHO WOULD PROVIDE THE PROGRAM IN “REAL WORLD” SETTINGS. OUR OBJECTIVE IN THIS PROPOSAL IS TO TEST THE EFFECTIVENESS FOR A LARGE SAMPLE, IN DIFFERENT CONTEXTS OF RISK, OF THE BRIEF (I.E. 4 SESSION) PSYCHO-EDUCATIONAL AND COMMUNICATION TRAINING APPROACH USED IN OUR EFFICACY TRIALS, AND TO EXAMINE THE MECHANISMS ASSOCIATED WITH CHANGE PROCESSES THAT OCCUR AS A RESULT OF THE PROGRAM, INCLUDING EMOTIONAL SECURITY AS A MEDIATOR OF PROGRAM EFFECTS AND MODERATORS OF EFFECTS ASSOCIATED WITH PARTICIPANTS’ SOCIOECONOMIC AND CONTEXTUAL RISKS AS WELL AS ORGANIZATIONAL FACTORS THAT MAY IMPACT PROGRAM EFFECTIVENESS. OUR CENTRAL HYPOTHESIS IS THAT PARTICIPATION IN THE PROGRAM WILL IMPROVE PATTERNS OF COMMUNICATION AND CONFLICT IN FAMILIES, THEREBY IMPROVING YOUTH MENTAL HEALTH. THIS HYPOTHESIS IS SUPPORTED BY EXTENSIVE EFFICACY RESEARCH ON THE HAPPY FAMILIES CURRICULUM AND CONCLUSIONS BASED ON A RECENTLY CONDUCTED FEASIBILITY STUDY OF THE PROPOSED EFFECTIVENESS TRIAL. OUR RATIONALE IS THAT PROVIDING A FAMILY-SYSTEMS APPROACH TO IMPROVING THE FAMILY ENVIRONMENT WILL SUPPORT YOUTH MENTAL HEALTH OVER TIME. THE SPECIFIC AIMS ARE: (1) EVALUATING PROGRAM EFFECTIVENESS FOR IMPROVING COMMUNICATION, REDUCING DESTRUCTIVE CONFLICT IN FAMILIES AND ENHANCING MENTAL HEALTH IN YOUTH, (2) TESTING PROCESS MODELS, GUIDED BY THE EMOTIONAL SECURITY THEORY (EST; DAVIES & CUMMINGS, 1994), TO EXPLAIN HOW, WHY, FOR WHOM AND WHEN, CHANGES OCCUR AS A RESULT OF THE PROGRAM, AND (3) EVALUATING ORGANIZATIONAL FACTORS ASSOCIATED WITH PROGRAM EFFECTIVENESS, INCLUDING THE IMPACT OF ORGANIZATION STRUCTURE AND FACILITATOR TYPE, AND ORGANIZATIONS’ SUBJECTIVE EVALUATION OF THE PROGRAM. THIS APPROACH IS INNOVATIVE BECAUSE IT UTILIZES AN RCT DESIGN TO TEST THE EFFECTIVENESS OF A PROVEN FAMILY-SYSTEMS APPROACH THAT REPRESENTS A BRIEF, INEXPENSIVE AND READILY SCALABLE APPROACH TO FOSTER CHANGE IN FAMILIES’ COMMUNICATION PATTERNS AND IMPROVE MENTAL HEALTH. THE PROGRAM IS BASED ON A WELL-ESTABLISHED THEORETICAL MODEL FOR “MECHANISMS OF EFFECT” AND BACKED BY EVIDENCE FOR PROGRAM EFFICACY. THIS RESEARCH IS SIGNIFICANT BECAUSE IT WILL RESULT IN AN INEXPENSIVE MODEL PROGRAM FOR FAMILY-SYSTEM-LEVEL INTERVENTIONS THAT IS SUSTAINABLE IN THE ORGANIZATIONS IT IS TESTED IN, AND READILY ADJUSTED TO OTHER CONTEXTS.
Department of Health and Human Services
$2.1M
M. AVIUM GPLS IN MACROPHAGE ACTIVATION AND VIRULENCE
Department of Energy
$2.1M
BERRY CURVATURE ENGINEERING OF SUPERCONDUCTORS
Department of Health and Human Services
$2.1M
INTERVENING DURING THE PRENATAL PERIOD WITH WOMEN EXPOSED TO INTIMATE PARTNER VIOLENCE TO IMPROVE MATERNAL FUNCTIONING AND INFANT ADJUSTMENT
Department of Defense
$2.1M
CONTROL OF VECTOR-BORNE DISEASES: DEVELOPMENT OF HUMAN-SAFE INSECTICIDES FOR US MILITARY PROTECTION AND IMPROVING GLOBAL HEALTH II
Department of Health and Human Services
$2.1M
MOLECULAR PROBES FOR BIOMEMBRANE RECOGNITION
National Science Foundation
$2.1M
DATA AND SOFTWARE PRESERVATION FOR OPEN SCIENCE (DASPOS)
Department of Health and Human Services
$2.1M
REGULATION OF OVARIAN CARCINOMA PROTEINASES
Department of Energy
$2M
NORTHWEST INDIANA COMPUTATIONAL GRID (NWIC-GRID)
National Science Foundation
$2M
EFRI BEGIN OI: IMPLANTATION OF DENSE ASSOCIATIVE MEMORY THROUGH CARDIAC MUSCLE CELL-BASED REPROGRAMMABLE BIO-OSCILLATORY NEURAL NETWORKS -ALL ORGANISMS COLLECT AND STORE INFORMATION. THIS HOLDS TRUE FOR SINGLE- AND MULTI-CELLED ORGANISMS. THE INFORMATION IS USED TO INFORM DECISION-MAKING. THIS INSIGHT LED TO THE NOTION OF BIOCOMPUTING. A PROMISING BIOCOMPUTING SYSTEM COULD INVOLVE CARDIAC MUSCLE CELLS. THEY NATURALLY TRANSMIT ELECTRICITY. THIS PROJECT IS DESIGNED TO EXPLORE THE PROGRAMMING OF ARRAYS OF CARDIAC MUSCLE CELLS. IF THESE ARRAYS ARE PROGRAMMABLE AND CAN STORE INFORMATION, THEY WOULD OFFER AN ENERGY-EFFICIENT COMPUTATIONAL SYSTEM. THE PROJECT WILL ALSO INVOLVE INTERDISCIPLINARY STUDENT MENTORING AND WORKSHOPS FOR UNDERGRADUATE AND HIGH SCHOOL STUDENTS. ONE WORKSHOP WILL BE DEDICATED TO ETHICAL, PHILOSOPHICAL, AND SOCIAL SCIENCE DIMENSIONS OF THE PROJECT. THE GOAL OF THIS PROJECT IS TO EXPLORE THE POTENTIAL OF USING HEART MUSCLE CELLS AS THE BASIS FOR A RECURRENT (HOPFIELD) NEURAL NETWORK. THE HYPOTHESIS IS THAT CARDIAC MUSCLE CELL-BASED REPROGRAMMABLE BIOOSCILLATOR NEURAL NETWORKS (CARBON) CAN IMPLEMENT SCALABLE AND HIGH-CAPACITY ASSOCIATIVE MEMORY. THE CARDIAC MUSCLE CELLS WILL BE CONNECTED BY FIBROBLASTS. A KEY COMPONENT OF THE PROJECT IS MODIFYING THE FIBROBLAST CELL LINES WITH OPTOGENETICALLY TUNABLE ION CHANNELS. THESE CHANNELS WOULD BE USED TO ADJUST THEIR CAPACITIVE (C), RESISTIVE (R) AND HYBRID-RC FILTER CHARACTERISTICS. THIS ENABLES THEIR APPLICATION AS PROGRAMMABLE WEIGHTS IN THE HOPFIELD RNN. THE RESEARCH HAS ETHICAL, LEGAL, AND SOCIAL IMPLICATIONS THAT WILL BE STUDIED BY EXPLORING QUESTIONS THAT WERE NEVER ANSWERED BEFORE. IN A HIGHLY CONVERGENT ENDEAVOR, THIS PROJECT WILL AIM TO STUDY QUESTIONS PERTAINING TO SYSTEMS CAPABLE OF DISPLAYING ASPECTS OF INTELLIGENCE, ESPECIALLY NOT IN TRADITIONAL ?REGULATORY ETHICS? WAY, BUT AROUND QUESTIONS THAT EXPLORE THE TOPIC FROM A CULTURAL AND TRADITIONAL STANDPOINT TO PHILOSOPHY OF MIND AND TO METAPHYSICAL QUESTIONS AROUND ?WHAT PROPERTIES DOES A ?COMPUTING? DEVICE OR SYSTEM NEED TO HAVE TO BE CALLED AN ?ENTITY,? ?LIVING? OR ?INTELLIGENT??, TO HISTORY AND PHILOSOPHY OF SCIENCE QUESTIONS SUCH AS ?WHAT IS THE HISTORY AND FUTURE OF BIOCOMPUTING?? NONE OF WHICH HAS BEEN ASKED BEFORE IN THE CONTEXT OF BIOCOMPUTING USING LIVING CELLS. THIS PROJECT IS JOINTLY FUNDED BY THE EMERGING FRONTIERS IN RESEARCH AND INNOVATION PROGRAM (BEGIN OI), THE DIRECTORATE FOR BIOLOGICAL SCIENCES, AND THE DIRECTORATE FOR MATHEMATICAL AND PHYSICAL SCIENCES. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE PLANNED FOR THIS AWARD.
National Science Foundation
$2M
EFRI 2-DARE: MONOLAYER HETEROSTRUCTURES: EPITAXY TO BEYOND-CMOS DEVICES
Department of Health and Human Services
$2M
EMPOWERING FUNCTIONAL GENOMICS OF AN. GAMBIAE THROUGH INVERSION GENOTYPING
Department of Health and Human Services
$2M
CHEMICAL APPROACHES TO SELECTIVELY TARGET BETA-RICH AMYLOIDS - PROJECT ABSTRACT PROTEIN-PROTEIN INTERACTIONS ARE GOVERNED BY RECOGNITION EVENTS BETWEEN PEPTIDE SECONDARY STRUCTURES (A- HELICES, B-SHEETS, LOOPS), WHICH IN TURN PROVIDE DESIGN CUES FOR THE DEVELOPMENT OF SELECTIVE CHEMICAL PROBES. HOWEVER, REMOVAL OF ORDERED PEPTIDE DOMAINS FROM THE CONTEXT OF THE SURROUNDING TERTIARY STRUCTURE COMPROMISES FOLDING AND CONFORMATIONAL STABILITY. MIMICRY AND DISRUPTION OF B-STRAND/SHEET INTERACTIONS REMAINS A CONSIDERABLE CHALLENGE. THIS IS LARGELY DUE TO THE INHERENT FLEXIBILITY OF SHORT PEPTIDE SEQUENCES, THE PROPENSITY FOR B-STRANDS TO AGGREGATE, AND THE LARGE SURFACE AREAS AND DIVERSE MODES OF B-SHEET PACKING. THE EARLY OLIGOMERIZATION OF SEVERAL AMYLOIDOGENIC PROTEINS INVOLVES CONFORMATIONAL REORGANIZATION INTO PARALLEL B-SHEET STRUCTURES, FOLLOWED SUPRAMOLECULAR ASSEMBLY INTO TOXIC FIBRILS. RECENT ATOMIC-LEVEL STRUCTURAL DATA USING PATIENT-DERIVED EXTRACTS HAS REVEALED THAT NEUROTOXIC AMYLOIDS MAY BE CHARACTERIZED BY UNIQUE STRUCTURAL POLYMORPHS, OR ‘STRAINS’, DEPENDING ON THE DISEASE. DESPITE THE NEED FOR AMYLOID- AND STRAIN-SPECIFIC LIGANDS, B-RICH AMYLOID ASSEMBLIES REPRESENT PARTICULARLY CHALLENGING TARGETS. WE RECENTLY ESTABLISHED PEPTIDE BACKBONE N-AMINATION AS A SUBTLE YET REMARKABLY EFFECTIVE APPROACH TO B-STRAND/SHEET STABILIZATION. THE CONFORMATIONAL AND NON-AGGREGATING CHARACTERISTICS OF N-AMINO PEPTIDES (NAPS) RENDER THEM UNIQUELY SUITED FOR CAPPING THE GROWTH OF SHEET FIBRILS WHILE MAINTAINING THE FACIAL PACKING AND SIDECHAIN INTERDIGITATION IMPORTANT FOR AMYLOID RECOGNITION. HERE, WE WILL FURTHER DEVELOP SOLUBLE MIMICS OF DIVERSE B-SHEET-LIKE FOLDS TO DISRUPT AMYLOID AGGREGATION IN A SEQUENCE AND STRAIN-SPECIFIC MANNER. AS A PROOF-OF-CONCEPT, WE WILL TARGET THE ASSEMBLY AND CELLULAR TRANSMISSION OF TAU FIBRILS THAT CHARACTERIZE NUMEROUS SPORADIC AND HEREDITARY NEURODEGENERATIVE DISORDERS. OUR OVERARCHING HYPOTHESIS IS THAT THE STRUCTURAL FEATURES OF PEPTIDE N-AMINATION WILL ENABLE THE DEVELOPMENT OF LIGANDS THAT SELECTIVELY TARGET B-RICH AMYLOID FOLDS. IN AIM 1 WE WILL EXPAND THE UTILITY OF NAP MODIFICATION IN PURSUIT OF HYPERSTABLE B-STRANDS AND AMYLOID MIMICS BASED ON PARALLEL B-SHEET MACROCYCLES. A LIBRARY OF NAP-BASED TAU MIMICS WILL BE SYNTHESIZED IN AIM 2. THESE COMPOUNDS WILL BE EVALUATED FOR THEIR ABILITY TO BLOCK AGGREGATION AND CELLULAR TRANSMISSION OF RECOMBINANT TAU FIBRILS AS WELL THOSE EXTRACTED FROM AD PATIENTS. IN AIM 3, WE WILL SYNTHESIZE A SERIES OF AGGREGATION-RESISTANT NAP MACROCYCLES THAT MIMIC THE CROSS-B PACKING OBSERVED IN PATHOGENIC TAU STRAINS. THESE WILL BE EVALUATED FOR THEIR CAPACITY TO SPECIFICALLY INHIBIT CELLULAR SEEDING BY TAU FIBRILS DERIVED FROM AD AND CBD BRAINS. WE ANTICIPATE THAT LIGANDS EMERGING FROM THIS STUDY WILL ENABLE A ROBUST EXAMINATION OF THE THE PATHOGENIC STRAIN MODEL OF TAU TRANSMISSION. MORE BROADLY, THESE STUDIES WILL HAVE A SIGNIFICANT IMPACT ON THE DESIGN OF OTHER SELECTIVE DISRUPTORS OF B-SHEET AND AMYLOID ASSEMBLIES THAT ARE INHERENTLY DIFFICULT TO TARGET.
National Science Foundation
$2M
DIMENSIONS US-CHINA: INTEGRATING THE DIMENSIONS OF BIODIVERSITY TO UNDERSTAND TREE PERFORMANCE IN A CHANGING WORLD
Department of Health and Human Services
$2M
COMPUTATIONAL BIOMECHANICS MODELING OF INFLAMMATION - PROJECT SUMMARY/ABSTRACT THE PHYSICAL LAWS THAT GOVERN THE UNIVERSE ALSO GOVERN THE HEALTHY FUNCTIONING OF LIVING TISSUES, AS WELL AS THE GENESIS AND DEVELOPMENT OF DISEASES. HISTORICALLY, THE BIOMEDICAL RESEARCH COMMUNITY HAS OVERLOOKED THE ROLE OF MECHANICS IN MANY DEVELOPMENTAL, PATHOLOGICAL, AND ADAPTIVE PROCESSES. IN MY RESEARCH GROUP, THE COMPU- TATIONAL MECHANICS OF MORPHOLOGY AT NOTRE DAME (COMMAND LAB), WE WORK AT THE INTERSECTION OF MECHANICS, COMPUTATION, AND BIOLOGY, TO INVESTIGATE THE COUPLED BIO-MECHANICAL BEHAVIORS OF TISSUES AND ORGANS, PARTICULARLY DURING GROWTH AND REMODELING. IN THIS PROPOSAL, WE AIM TO EXTEND OUR WORK TO THE STUDY OF INAMMATORY SWELLING. SIMILARLY TO GROWTH, INAMMATION AND SWELLING INVOLVE LOCAL CHANGES IN MASS (FOR INSTANCE, DUE TO AN INUX OF CELLS) WHICH CAN MANIFEST AS CHANGES IN VOLUME. WHILE EXTERNAL SWELLING IS OFTEN USED AS AN INDICATOR OF UNDER- LYING INAMMATION, CONSTRAINTS FROM SURROUNDING TISSUE CAN ALSO RESTRICT SWELLING AND INSTEAD RESULT IN INCREASES IN PRESSURE. IN ADDITION, INAMMATION CAN DRASTICALLY CHANGE THE CELLULAR COMPOSITION OF A TISSUE. INAMMATION IS WIDESPREAD AMONG DIFFERENT TISSUES, AND THESE SEQUELAE CAN HAVE IMPORTANT IMPLICATIONS FOR THE DIAGNOSIS, DE- VELOPMENT, AND TREATMENT OF DIFFERENT DISEASES. WE WILL DEVELOPING NOVEL COMPUTATIONAL MODELS OF INAMMATION AND SWELLING THAT 1) ALLOW FOR CELL BEHAVIOR TO VARY SPATIALLY, TEMPORALLY, AND BY CELL TYPE; 2) ACCOUNT FOR MECHANICAL INTERACTIONS BETWEEN THE SWELLING TISSUE AND SURROUNDING TISSUES; AND 3) REPORT RESULTS IN A WAY THAT FACILITATES CALIBRATION, VALIDATION, AND COMPARISONS WITH EXPERIMENTAL. THIS WORK WILL PROVIDE TOOLS FOR PROBING SMALL-SCALE PHENOMENA BEYOND LARGE-SCALE SWELLING, EXPLORING THE EFFECTS OF INDIVIDUAL PARAMETERS, AND TESTING HYPOTHESES REGARDING THE BIOMECHANICS OF INAMMATION IN SILICO. 1
Department of Health and Human Services
$2M
DETERMINATION OF THE STRUCTURE, DYNAMICS AND ENERGETICS OF ENZYME REACTIONS - A. PROJECT SUMMARY/ABSTRACT “HOW DO ENZYMES WORK?” THIS BASIC QUESTION IS OF CENTRAL IMPORTANCE IN BIOCHEMISTRY AND, GIVEN THE UBIQUITOUS ROLE OF ENZYMES IN LIFE AND DISEASE PROCESSES, IN THE BIOMEDICAL SCIENCES. ANSWERING THE QUESTION ENTAILS KNOWLEDGE OF HOW EACH ATOM IN THE SYSTEM MOVES AND HOW THE FREE ENERGY CHANGES AS THE REACTION PROGRESSES TO PROVIDE ATOMIC-LEVEL DETAIL OF THE STRUCTURAL, DYNAMIC AND ENERGETIC FEATURES OVER THE ENTIRE REACTION PATH. IN REALITY, ONLY INCOMPLETE AND INDIRECT KNOWLEDGE IS CURRENTLY ACCESSIBLE, REQUIRING THE APPLICATION OF A COMBINED METHODOLOGY THAT BRIDGES THE MANY TIMESCALES OF THE REACTION. THE PRESENT APPLICATION ADDRESSES TWO IMPORTANT CHALLENGES: (I) THE DEVELOPMENT OF VERY FAST METHODS FOR THE STUDY OF ENZYMATIC TRANSITION STATES AND (II) STUDIES OF HOW AND ENZYME CATALYZES A COMPLEX REACTION. SUPPORTED BY THE CURRENT R01 FUNDING, WE MADE SIGNIFICANT PROGRESS TOWARDS BOTH CHALLENGES, DEMONSTRATING IN A SERIES OF RELEASED PUBLICATIONS, CODES AND STRUCTURES THAT THE INNOVATIVE APPROACH OF COUPLING REACTION- SPECIFIC TRANSITION STATE FORCE FIELDS (TSFFS) WITH TIME-RESOLVED CRYSTALLOGRAPHY (TRC) RESULTS IS UP TO THESE CHALLENGES. THE POWER OF THESE METHODS WAS DEMONSTRATED FOR THE CASE OF PSEUDOMONAS MEVALONII HMG COA REDUCTASE (PMHMGR), WHICH WAS CHOSEN BECAUSE IT: 1) HAS A COMPLEX REACTION MECHANISM INVOLVING TWO HYDRIDE TRANSFERS, A THIOHEMIACETAL BREAKDOWN AND TWO COFACTOR EXCHANGE STEPS, 2) CAN BE REVERSIBLE RUN IN THE CRYSTAL AND 3) HAS A WEALTH OF EXPERIMENTAL DATA FOR THE VALIDATION OF THE METHODOLOGY AVAILABLE. IT IS ALSO REPRESENTATIVE OF MANY OTHER ENZYMES TO WHICH THIS METHODOLOGY COULD BE APPLIED. FUTURE WORK TOWARDS IMPORTANT CHALLENGE 1 WILL ADDRESS THE FACT THAT TSFFS ARE REACTION SPECIFIC AND NEED TO BE REFITTED FOR EACH REACTION BY ACCELERATING AND AUTOMATING THE QUANTUM-GUIDED MOLECULAR MECHANICS (Q2MM) METHOD WITH TWO INNOVATIONS: (I) FUERZA, WHICH GENERATES IMPROVED INITIAL GUESS FOR FORCE CONSTANTS BY PROJECTING OUT CROSS-TERMS BETWEEN THE REPARAMETERIZED AND LITERATURE FORCE FIELD TERMS AND (II) A E-CONSTRAINED PARTICLE SWARM OPTIMIZER (PSO) TO AUTOMATE THE MINIMIZATION OF THE MERIT FUNCTION IN A HIGH DIMENSIONAL, MULTI-MINIMA SPACE. WE WILL THEN DEMONSTRATE THE GENERALITY OF THIS APPROACH BY APPLYING FITTING TSFFS FOR THE DISTINCT CHEMICAL REACTIONS CATALYZED BY PMHMGR. FOR IMPORTANT CHALLENGE 2, WE WILL ) USE THE TSFFS FOR ΜSEC MD SIMULATIONS WITH THE LONG-TERM GOAL OF GENERATING OVERLAPPING ENSEMBLES ALONG THE ENTIRE REACTION PATHWAY OF PMHMGR, INCLUDING THE CHEMICALLY MOST RELEVANT PORTIONS AROUND THE TRANSITION STATES. ANALYSIS OF THE MD TRAJECTORIES USING MARKOV STATE MODELS (MSM) AND GENERALIZED MASTER EQUATION (GME) TECHNIQUES THAT PROVIDES THE STRUCTURES USED IN THESE WORKFLOWS AND INFORMS THE MOST INFORMATIVE TIME POINTS THAT ARE VALIDATED BY ITERATIVELY LINKING THEM TO TRC IN A PHYSICALLY RIGOROUS MANNER. SOME OF THE TRC DATA IS ALREADY IN HAND WHILE HIGHER TIME RESOLUTION DATA WILL BE GENERATED IN COLLABORATION IMPROVED PH JUMP AND RAPID-FREEZE METHODS BY EXTENDING THE EXISTING COLLABORATION WITH THE STAUFFACHER AND COHEN GROUPS. 1
Department of Health and Human Services
$1.9M
INFLUENCE OF TRANSLATION ON PROTEIN FOLDING
Department of Health and Human Services
$1.9M
AN INTEGRATED HUMAN ORGAN-ON-CHIP ULTRASENSITIVE MIRNA DETECTION PLATFORM FOR NOVEL BIOMARKER DISCOVERY
National Science Foundation
$1.9M
QUARKNET -THIS AWARD SUPPORTS THE CONTINUATION OF QUARKNET, A PROGRAM WHICH PROVIDES VALUABLE RESEARCH EXPERIENCE TO HIGH SCHOOL TEACHERS, ENABLING THEM TO TEACH THE BASIC CONCEPTS OF INTRODUCTORY PHYSICS IN A CONTEXT THAT STUDENTS FIND EXCITING. QUARKNET HAS CREATED AN ONGOING NATIONAL COMMUNITY OF RESEARCHERS THAT INCLUDE HIGH SCHOOL TEACHERS AND STUDENTS AS WELL AS PHYSICISTS. QUARKNET'S GOALS ARE TO MAINTAIN AND ENHANCE THIS COMMUNITY, TO ATTRACT YOUNG STUDENTS TO CAREERS IN SCIENCE AND TECHNOLOGY, TO HELP DEVELOP SCIENTIFIC LITERACY IN SOCIETY, AND TO DEVELOP LINKS BETWEEN THE HIGH SCHOOL CLASSROOM AND EXPERIMENTS AND TECHNIQUES USED TO EXPLORE THE SCIENTIFIC FRONTIER. KEY FEATURES OF QUARKNET ARE THE ESTABLISHMENT OF MENTOR RELATIONSHIPS BETWEEN TEACHERS AND SCIENTISTS, SUMMER RESEARCH EXPERIENCES FOR TEACHERS, AND THE DEVELOPMENT OF A SCIENTIFIC AND LEARNING COMMUNITY WITHIN AND AMONG CENTERS. QUARKNET PROVIDES OPPORTUNITIES FOR TEACHERS TO BECOME MORE PROFESSIONAL, RESULTING IN THE DEVELOPMENT OF PROGRAMMING FOR PEERS IN THE CENTER, IN THEIR SCHOOLS AND DISTRICTS AND BEYOND. QUARKNET PROVIDES A CENTRALLY HOSTED, SCALABLE, PARALLEL CYBERLEARNING ENVIRONMENT AS A CLOUD-LIKE SERVICE. HELD AT UNIVERSITY AND LABORATORY CENTERS, MASTERCLASSES ARE INSTITUTES FOR TEAMS OF STUDENTS WHO BECOME PHYSICISTS FOR A DAY, ANALYZING REAL EXPERIMENTAL DATA AND DISCUSSING RESULTS IN VIDEOCONFERENCES WITH PEERS AND PHYSICISTS. UNDER THIS THREE-YEAR AWARD, QUARKNET WILL SUPPORT MORE THAN 50 CENTERS PARTICIPATING IN A VARIETY OF EXPERIMENTS AT CERN, FERMILAB AND IN NON-ACCELERATOR AND ASTROPHYSICS PROGRAMS. IN THIS THREE-YEAR PERIOD, THE QUARKNET PROGRAM WILL SUPPORT: (1) THE LOCAL PROGRAMS OF THE LONG-TERM QUARKNET CENTERS FOR ~400 TEACHERS PER YEAR WHO RECEIVE STIPENDS; (2) A FEW TEACHERS WITH MULTI-WEEK SUMMER RESEARCH APPOINTMENTS TO WORK UNDER THE GUIDANCE OF PHYSICISTS FROM A UNIVERSITY OR LABORATORY NEAR THEIR HOMES SHOULD NEW CENTERS JOIN THE COLLABORATION; (3) 72 TEACHERS WHO WILL ATTEND A ONE-WEEK PARTICLE PHYSICS DATA CAMP AT FERMILAB TO BE IMMERSED IN AN INTENSIVE EXPERIENCE TO LEARN MORE PARTICLE PHYSICS AND ONE THAT MODELS AN INVESTIGATION APPROACH TO INQUIRY TEACHING AND LEARNING; (4) 72 TEACHERS WILL ATTEND A ONE-WEEK CODING CAMP. CODING CAMPS PUT AUTHENTIC EXPERIMENTAL DATA INTO THE HANDS OF TEACHERS AND PROVIDE THE APPROPRIATE BACKGROUND, IT TOOLS, TRAINING AND SUPPORT THAT ALLOWS THEM TO SUCCESSFULLY GUIDE THEIR STUDENTS IN CLASSROOM RESEARCH INVESTIGATIONS. (5) 32 FELLOWS WITH CONTINUING TRAINING THAT GIVES THEM THE KNOWLEDGE AND SKILLS TO OFFER PROFESSIONAL DEVELOPMENT EXPERIENCES FOR OTHER TEACHERS; AND (6) 60 TEACHERS WHO WILL BE INVOLVED WITH MASTERCLASSES. OVER THE THREE YEARS (2023-2026) THIS PROJECT IS EXPECTED TO REACH, IN ADDITION TO THE TEACHERS, MORE THAN 150 PHYSICISTS, AND EVENTUALLY WELL OVER 60,000 STUDENTS. A PORTION OF THIS EFFORT IS SUPPORTED THROUGH THE NSF ATLAS AND CMS OPERATIONS AWARDS. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.
National Science Foundation
$1.9M
COLLABORATIVE RESEARCH: CSSI FRAMEWORKS: FROM NOTEBOOK TO WORKFLOW AND BACK AGAIN -COMPUTATIONAL NOTEBOOKS HAVE BECOME A CORNERSTONE OF THE SCIENTIFIC COMPUTING ENTERPRISE, PROVIDING AN INTERACTIVE MEANS TO ACQUIRE AND COMMUNICATE INSIGHTS, SHARE DISCOVERIES, AND VISUALIZE EXPERIMENTAL OUTCOMES. HOWEVER, COMPUTATIONAL NOTEBOOKS TODAY ARE MOST SUITED FOR SMALL-SCALE EXPLORATIONS CARRIED OUT ON A SINGLE COMPUTER, AND ARE QUITE DIFFICULT TO USE FOR LARGE-SCALE COMPUTATIONS ON HIGH PERFORMANCE COMPUTING CLUSTERS OR COMMERCIAL CLOUDS. THIS PROJECT WILL DEVELOP NBFLOW, A SOFTWARE TOOLKIT FOR CONVERTING NOTEBOOK COMPUTATIONS INTO WORKFLOWS THAT ARE FEASIBLE TO EXECUTE EFFICIENTLY ON CLUSTERS OR CLOUDS. THIS WILL MAKE IT POSSIBLE TO USE NOTEBOOK TECHNOLOGIES IN CONJUNCTION WITH HIGH PERFORMANCE CLUSTERS TO ENABLE NEW DISCOVERIES IN SCIENTIFIC FIELDS SUCH AS HIGH ENERGY PHYSICS AND GEOSCIENCES. THESE TECHNOLOGIES WILL BE USED TO DEVELOP NEW EDUCATIONAL CURRICULA, OUTREACH ACTIVITIES FOR K-12 STUDENTS, AND RESEARCH EXPERIENCES FOR COLLEGE STUDENTS. NBFLOW WILL SUPPORT AND ADVANCE THE USE OF COMPUTATIONAL NOTEBOOKS IN SCIENTIFIC RESEARCH AND DATA ANALYSIS BY BRIDGING THE GAP BETWEEN INTERACTIVE COMPUTATION AND DISTRIBUTED CYBERINFRASTRUCTURE DEVELOPED FOR DATA-INTENSIVE SCIENCES. TODAY'S NOTEBOOK ENVIRONMENTS PROVIDE EASY ACCESS TO STANDARD ARTIFICIAL INTELLIGENCE AND MACHINE LEARNING TOOLKITS FOR PROCESSING VAST DATASETS WITH GREATER EFFICIENCY AND ACCURACY COMPARED TO CONVENTIONAL METHODS. HOWEVER, MIGRATING A NOTEBOOK FROM A SCRATCHPAD-LIKE ANALYSIS TO A ROBUST PIPELINE, WHICH MUST BE DISTRIBUTED ACROSS A CLUSTER OR CLOUD INFRASTRUCTURE, CURRENTLY REQUIRES SIGNIFICANT EFFORTS BY DEVELOPERS AND SCIENTISTS. NBFLOW WILL BUILD UPON EXISTING NSF INVESTMENTS IN THE AREAS OF CONTAINERIZATION AND WORKFLOWS THAT WILL RECORD NOTEBOOK EXECUTIONS AND SCHEDULE TASKS FOR CONCURRENT EXECUTION. BY EXPERIMENTING WITH AN INTEGRATED NOTEBOOK-WORKFLOW SYSTEM, THIS CUTTING-EDGE RESEARCH WILL ADVANCE UNDERSTANDING IN DATA MANAGEMENT AND DISTRIBUTED COMPUTING SUB-FIELDS. AT THE SAME TIME, THE PROJECT WILL PRODUCE NOVEL TECHNIQUES TO ROBUSTLY CAPTURE PROVENANCE FROM NOTEBOOK-BASED WORKFLOWS, A RICH SOURCE OF DATA IN ITSELF, AS WELL AS PUT TECHNIQUES DEVELOPED FOR INCREMENTAL COMPUTATION TO PRACTICE. THESE TECHNOLOGIES WILL BE DEPLOYED WITH ACTIVE USER COMMUNITIES IN HIGH ENERGY PHYSICS AT MULTIPLE FACILITIES AND IN GEOSPATIAL AND SUSTAINABILITY SCIENCES THROUGH THE I-GUIDE CYBERINFRASTRUCTURE. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.
Department of Energy
$1.9M
IONIC LIQUIDS FOR THE UTILIZATION OF GEOTHERMAL ENERGY
Department of Health and Human Services
$1.9M
THE UNIQUE AND COMBINED EFFECTS OF PRENATAL AND EARLY CHILDHOOD PROGRAMMING ON CHILD MALTREATMENT: EXAMINING MECHANISMS OF CHANGE - PROJECT SUMMARY/ABSTRACT CHILD MALTREATMENT OCCURS AT ALARMINGLY HIGH RATES AND REPRESENTS A SERIOUS THREAT TO CHILDREN’S HEALTHY DEVELOPMENT, WITH NEGATIVE RAMIFICATIONS LASTING INTO ADULTHOOD. EXPOSURE TO INTIMATE PARTNER VIOLENCE (IPV), CHILD ABUSE, AND NEGLECT ARE PARTICULARLY DETRIMENTAL AND FREQUENTLY CO-OCCUR. IPV, WHICH TYPICALLY HAS AN ONSET DURING WOMEN’S CHILDBEARING YEARS, IS ONE OF THE SINGLE LARGEST RISK FACTORS FOR SUBSEQUENT CHILD MALTREATMENT. THEREFORE, PREVENTING CHILD IPV EXPOSURE IS CRITICAL FOR CHILD MALTREATMENT PREVENTION AND MAY BE EFFECTIVELY TARGETED IN PROGRAMMING DURING PREGNANCY. IN ORDER TO PROMOTE A HEALTHY PARENT-CHILD RELATIONSHIP, ENHANCING MATERNAL SENSITIVITY IS ANOTHER KEY PROCESS THAT SHOULD BE TARGETED IN PREVENTION APPROACHES FOR CHILD MALTREATMENT. IN THIS PROJECT, WE PROPOSE AN INNOVATIVE APPROACH THAT COMBINES EFFORTS TO ADDRESS IPV AND TO SUPPORT THE MOTHER-CHILD RELATIONSHIP IN TWO DEVELOPMENTAL PERIODS TO PREVENT CHILD MALTREATMENT. USING A MULTI-SITE, RANDOMIZED CONTROLLED TRIAL DESIGN, THE PROPOSED PROJECT AIMS TO ASSESS THE INDIVIDUAL AND COMBINED CONTRIBUTIONS OF PRENATAL AND POSTNATAL PROGRAMMING TO PREVENT CHILD MALTREATMENT. WE WILL EVALUATE THE PREGNANT MOMS’ EMPOWERMENT PROGRAM (PMEP), A 5-SESSION GROUP PROGRAM FOR WOMEN EXPOSED TO IPV THAT IS DELIVERED DURING PREGNANCY, AND THE REMINISCING AND EMOTION TRAINING (RET) PROGRAM AS AN ADDITIONAL PREVENTATIVE PROGRAM DELIVERED WHEN CHILDREN ARE 3-6 YEARS OLD. IN ADDITION TO TESTING THE INDEPENDENT AND SYNERGISTIC EFFECTS OF THE PROGRAMS IN PREVENTING CHILD MALTREATMENT, WE WILL EVALUATE MECHANISMS OF TREATMENT CHANGE. PARTICIPANTS WILL INCLUDE 300 MOTHER-CHILD DYADS DRAWN FROM AN ONGOING RANDOMIZED CONTROLLED TRIAL OF PMEP (N=230; R01HD098092, MPIS MILLER-GRAFF & HOWELL) AND NEWLY RECRUITED PREGNANT, IPV-EXPOSED WOMEN WHO WILL COMPLETE THE IDENTICAL PMEP RANDOMIZED CONTROLLED TRIAL PROTOCOL AT THE BEGINNING OF THE CURRENT GRANT PERIOD (N=70). THE PMEP TRIAL ARM INCLUDES RANDOMIZATION TO PMEP OR PRENATAL CONTROL CONDITIONS, AND 4 ASSESSMENTS (BASELINE [T1], POST-TEST [T2], 3-MONTH [T3] AND 12-MONTH [T4] POST-PARTUM FOLLOW-UPS). WHEN THE CHILDREN OF WOMEN WHO PARTICIPATED IN THE PMEP TRIAL ARM ARE 3-6 YEARS OLD, DYADS WILL BE RE-RANDOMIZED TO RECEIVE RET OR EARLY CHILDHOOD CONTROL CONDITIONS. FAMILIES WILL COMPLETE 4 ADDITIONAL ASSESSMENTS DURING THE RET TRIAL ARM (BASELINE [T5], POST-TEST [T6], 3-MONTH [T7] AND 6-MONTH [T8] FOLLOW-UPS). THUS, THE STUDY IS A 2X2 RANDOMIZED FACTORIAL DESIGN (I.E., PMEP IN PREGNANCY (Y/N) X RET IN EARLY CHILDHOOD (Y/N)). OUR CENTRAL HYPOTHESIS IS THAT THE PMEP AND RET PROGRAMS WILL EACH PREVENT CHILD MALTREATMENT. WE ANTICIPATE THAT THE EFFECT OF PMEP WILL BE MEDIATED BY CHANGE IN IPV AND MATERNAL SENSITIVITY, WHILE THE EFFECT OF RET WILL BE MEDIATED BY CHANGE IN MATERNAL SENSITIVITY. WE FURTHER EXPECT THAT THE EFFECTS OF RET ON CHILD MALTREATMENT WILL BE MAGNIFIED FOR WOMEN WHO PARTICIPATED IN PMEP, SUCH THAT RET IS MORE EFFECTIVE IN THE CONTEXT OF PMEP- RELATED REDUCTIONS IN IPV AND ENHANCEMENT OF MATERNAL SENSITIVITY. THIS PROJECT IS INNOVATIVE IN ITS USE OF A MULTI-SITE, MULTI-METHOD DESIGN AND SIGNIFICANT IN ADDRESSING THE NEEDS OF A VULNERABLE POPULATION.
Department of Health and Human Services
$1.9M
TUBOVESICULAR TRAFFIC INDUCED IN RED CELLS IN PLASMODIA
Corporation for National and Community Service
$1.9M
THIS AWARD APPROVES FUNDING FOR THE 2023-24 VOLUNTEER GENERATION FUND PROGRAM DESCRIBED IN THE APPROVED PROGRAM NARRATIVE AND BUDGET. YOUR 2023-24 REGULATORY MATCH IS 20%, AND YOUR BUDGETARY MATCH IS 36.67%.
National Science Foundation
$1.9M
IGERT: GLOBAL LINKAGES OF BIOLOGY, ENVIRONMENT, AND SOCIETY (GLOBES)
Department of Defense
$1.9M
DRI: THE ARABIAN SEA TRANSITION LAYER (ASTRAL): EXCHANGE ACROSS THE AIR-SEA INTERFACE
Department of Health and Human Services
$1.9M
MATURATION OF BACTERIAL CELL WALL
Department of Health and Human Services
$1.8M
DETERMINANTS OF GROWTH AND FITNESS IN DRUG RESISTANT MALARIA PARASITES
Department of Health and Human Services
$1.8M
ENGINEERED HYBRID AGING MODEL FOR DISEASE PROGRESSION - PROJECT SUMMARY AGING IS A RISK FACTOR FOR MANY DISEASES SUCH AS CANCER, CARDIOVASCULAR DISEASES AND NEURODEGENERATIVE DISEASES, WITH THE INCIDENCE OF SUCH DISEASES PEAKING BETWEEN AGES 60 AND 80. ALTHOUGH BOTH THE CELLULAR AND THE EXTRACELLULAR COMPONENTS OF A TISSUE CHANGE WITH AGE, CURRENT PRECLINICAL MODELS HAVE FOCUSED ON THE AGING-RELATED CHANGES IN CELLS AND OVERLOOKED THE ALTERATIONS IN THE MICROENVIRONMENT, SPECIFICALLY THE EXTRACELLULAR MATRIX (ECM), WHICH IS ONE OF THE MAIN REASONS FOR THE LOW SUCCESS RATE OF PRE-CLINICAL TO CLINICAL TRANSLATION. THUS, IT IS IMPERATIVE TO CREATE DISEASE MODELS THAT MIMIC THE AGING MICROENVIRONMENT TO BETTER STUDY DISEASE INITIATION AND PROGRESSION, AS WELL AS RELIABLY TEST FOR DRUG EFFICACY. HERE, AS A PROOF-OF-CONCEPT AGING-ASSOCIATED DISEASE, FOR THE FIRST TIME IN LITERATURE, WE PROPOSE TO ENGINEER DECELLULARIZED AGED HUMAN ECM (DECM)-BASED 3D TUMOR MODELS AND IMPLANT THEM INTO IMMUNODEFICIENT MICE TO CREATE HYBRID MOUSE MODELS TO STUDY THE EFFECT OF MATRIX AGE ON TUMOR PROGRESSION AND DRUG RESPONSE. WE WILL FOLLOW A BOTTOM-UP APPROACH TO ESTABLISH THE HYBRID MOUSE MODEL; FIRST WE WILL ENGINEER THE AGING STROMA USING AGED HUMAN BREAST DECM AND AGED HUMAN STROMAL CELLS BOTH DERIVED FROM HEALTHY DONORS, THEN GROW AGED PATIENT-DERIVED TUMOR ORGANOIDS ON THE STROMA TO ENGINEER THE 3D IN VITRO TUMOR MODELS, AND FINALLY IMPLANT THE 3D TUMORS INTO IMMUNODEFICIENT MICE TO CREATE THE HYBRID MOUSE MODELS. HENCE, WE AIM TO ESTABLISH RELIABLE AND HUMAN REPRESENTATIVE PRECLINICAL MODELS, 3D TUMOR MODELS AND HYBRID MOUSE MODELS, WHICH ALLOW US TO DISTINGUISH THE INDIVIDUAL AND COMBINED EFFECT OF AGING COMPONENTS (I.E. ECM, STROMAL CELLS, AND TUMOR CELLS) ON TUMOR INITIATION AND PROGRESSION. WE WILL THEN MECHANISTICALLY TEST THE INDIVIDUAL EFFECTS OF AGED ECM CHARACTERISTICS, SUCH AS THE ALTERED STIFFNESS, FIBER STRUCTURE AND BIOCHEMICAL COMPOSITION ON TUMOR PROGRESSION. THE PROPOSED WORK AIMS AT SOLVING MANY PROBLEMS OF THE CURRENT PRECLINICAL MODELS. FIRST, WE WILL PRODUCE IN VITRO AND IN VIVO PRECLINICAL MODELS THAT CONSIDER THE EFFECT OF AGING HUMAN ECM ON CANCER PROGRESSION. SECOND, BY CREATING HYBRID MODELS, WE WILL ADDRESS THE LACK OF SYSTEMIC RESPONSE IN THE 3D MODELS, AND THE LACK OF CONTROL AND INABILITY TO DISCERN THE EFFECTS OF INDIVIDUAL COMPONENTS IN IN VIVO MODELS. FINALLY, WE WILL CREATE TUMORS IN MICE THAT BETTER REPRESENT THE HUMAN RESPONSE AND BENCHMARK OUR HYBRID MODEL WITH ACTUAL PATIENT SAMPLES. TO ACHIEVE THESE GOALS, WE WILL COMBINE OUR EXPERTISE IN TISSUE ENGINEERING, MOUSE MODEL SYSTEMS, TRANSCRIPTOMICS, PRIMARY CELL CULTURE MODEL SYSTEMS, AND BREAST CANCER RESEARCH. ONCE FULLY IMPLEMENTED AND FUNCTIONALLY VALIDATED, WE EXPECT OUR STATE-OF-THE-ART TISSUE ENGINEERED 3D DISEASE MODELS AS WELL AS THE HYBRID MOUSE MODELS TO SERVE AS THE NEXT-GENERATION RESEARCH PLATFORM FOR BOTH BASIC AND TRANSLATIONAL CANCER RESEARCH AND HIGH-THROUGHPUT DRUG DISCOVERY.
Department of Energy
$1.8M
OPTIMIZING ADDITIVE MANUFACTURING OF THERMOELECTRIC MATERIALS USING BAYESIAN OPTIMIZATION-ENHANCED TRANSFER LEARNING
Department of Health and Human Services
$1.8M
DEVELOPING INSERTABLE CARDIAC MONITORS TO ASSESS SOCIAL AND ENVIRONMENTAL EFFECTS ON THE AUTONOMIC STRESS RESPONSE IN A NONHUMAN PRIMATE MODEL OF AGING - PROJECT SUMMARY THE LONG REACH OF EARLY LIFE REMAINS ONE OF THE MOST ENDURING PUZZLES IN HUMAN HEALTH. FROM FAMINE TO POVERTY AND NEGLECT, ADVERSE EARLY LIFE EXPERIENCES LEAD TO HIGHER MORTALITY AND ELEVATED RISK FOR OBESITY, DIABETES, AND CHRONIC HEART DISEASE. THESE EFFECTS ARE LIKELY MEDIATED, IN PART, BY THE STRESS RESPONSE, A CASCADE OF NEUROENDOCRINE, METABOLIC, AND CARDIAC RESPONSES TO CHALLENGE INVOLVING THE HYPOTHALAMIC– PITUITARY–ADRENAL (HPA) AXIS AND THE AUTONOMIC NERVOUS SYSTEM. IN SUPPORT, SEVERAL LEADING HYPOTHESES PROPOSE THAT REPEATED SOCIAL AND ENVIRONMENTAL STRESSORS—BOTH IN EARLY LIFE AND ADULTHOOD—CAUSE OVER- ACTIVATION OF THE STRESS RESPONSE, CHRONIC STRESS, AND ACCELERATED AGING. LONG-TERM STUDIES OF NATURAL ANIMAL POPULATIONS OFFER COMPELLING MODELS FOR TESTING THESE IDEAS BECAUSE THEY OFTEN HAVE FINE-GRAINED, PROSPECTIVE, LONGITUDINAL DATA ON SOCIAL AND ENVIRONMENTAL STRESSORS FROM INDIVIDUALS ACROSS THE LIFE COURSE. HOWEVER, NATURAL ANIMAL MODELS ALSO FACE CONSIDERABLE CHALLENGES IN MEASURING MULTIPLE FACETS OF THE STRESS RESPONSE: MOST ARE CONSTRAINED TO MEASURING GLUCOCORTICOIDS (GCS) AS THE SOLE MEASURE OF STRESS RESPONSES, REFLECTING JUST ONE ASPECT OF THE HPA AXIS WITH NO INFORMATION ON AUTONOMIC RESPONSES. THIS LIMITATION HAS LED MANY TO CALL FOR EXPANDED TOOLS TO MEASURE STRESS RESPONSES IN NATURAL ANIMAL MODELS OF AGING. OUR OBJECTIVES IN THIS PROPOSAL ARE TO: (1) EXPAND THE TOOLS FOR MEASURING THE CARDIOMETABOLIC CONSEQUENCES OF STRESS IN NATURAL ANIMAL MODELS BY VALIDATING INSERTABLE CARDIAC MONITORS (ICMS) WITH ACCELEROMETRY TO MEASURE HEART RATE, HEART RATE VARIABILITY, AND PHYSICAL ACTIVITY; AND (2) TEST THE SOCIAL AND ENVIRONMENTAL DRIVERS OF THE AUTONOMIC STRESS RESPONSE AND ITS METABOLIC CONSEQUENCES. WE WILL DEVELOP AND VALIDATE ICMS USING CAPTIVE BABOONS AT THE INSTITUTE OF PRIMATE RESEARCH IN KENYA, AND A WELL-STUDIED, NATURAL POPULATION OF BABOONS IN AMBOSELI, ALSO IN KENYA. PRIOR WORK IN AMBOSELI HAS ALREADY SHOWN THAT AN ACCUMULATION OF HARSH CONDITIONS IN EARLY LIFE AND SOCIAL ISOLATION IN ADULTHOOD EXERT PROFOUND EFFECTS ON ADULT MORTALITY, SETTING THE STAGE TO PROBE THE STRESS RESPONSES UNDERLYING THESE LINKS. WHILE EARLY LIFE ADVERSITY AND SOCIAL ISOLATION LEAD TO ELEVATED GCS IN ADULTHOOD, AND ANIMALS WITH HIGH LIFELONG GCS HAVE LOWER SURVIVAL, GCS DO NOT MEDIATE THE LINK BETWEEN EARLY ADVERSITY AND LIFE SPAN. GAINING A BROADER PERSPECTIVE ON INDIVIDUAL STRESS RESPONSES AND THEIR CONSEQUENCES IS AN ESSENTIAL NEXT STEP. THE RESULTS WILL CONTRIBUTE THE FIRST PROSPECTIVE, LONGITUDINAL DATA IN ANY SPECIES TO UNDERSTAND HOW EARLY LIFE ADVERSITY AND ADULT SOCIAL CONDITIONS INTERACT TO SHAPE ACUTE AUTONOMIC STRESS RESPONSES, CHRONIC STRESS, AND ENERGY EXPENDITURE. THIS STUDY WILL PROVIDE A DIRECT LINK BETWEEN SOCIO-ENVIRONMENTAL CIRCUMSTANCES, STRESS RESPONSES, AND ADULT HEALTH, HELPING TO IDENTIFY KEY TARGETS TO MITIGATE THE EFFECTS OF STRESS OVER THE LIFE COURSE ON AGING.
Department of Energy
$1.8M
NEW; TITLE: IN SITU CORRELATED MOLECULAR IMAGING OF CHEMICALLY COMMUNICATING MICROBIAL COMMUNITIES; PI: PAUL BOHN
Department of Health and Human Services
$1.8M
CONFOCAL MICROSCOPY FOR ENGINEERING STEM CELL MICROENVIRONMENT IN LYMPHATIC REGENERATION - PROJECT SUMMARY THE SUPPLEMENT FUND IS REQUESTED UNDER PA-18-591 AND NOT-GM-20-013 TO PURCHASE A CONFOCAL MICROSCOPY SYSTEM, WHICH WILL SUPPORT NIGMS MIRA AWARD R35GM143055-01. THE RESEARCH PROGRAM SUPPORTED BY THIS AWARD LIES AT THE INTERFACE BETWEEN ENGINEERING AND MEDICINE, WITH A MOTIVATION ON MAKING STEM CELLS AND MOLECULAR THERAPIES AS AN EFFECTIVE METHOD TO MODEL AND TREAT LYMPHATIC DISEASES. TOWARD THIS GOAL, THE RESEARCH PROGRAM IS WORKING AT THE FOREFRONT OF DEVELOPING TRANSDISCIPLINARY APPROACHES BY COMBINING STEM CELL AND BIOENGINEERING, BIOMATERIALS, AND MICROFLUIDICS, AS WELL AS LYMPHATIC AND SYSTEMS BIOLOGY TECHNIQUES TO DEVELOP THE NECESSARY COMPONENT IN THERAPEUTIC LYMPHANGIOGENESIS. MAJOR AMOUNT OF THE WORK IN THE PROJECT NOW RELIES ON ENGINEERING STEM CELLS AND HYDROGELS FOR IN VITRO AND IN VIVO MODELS OF LYMPHATIC VASCULATURES IN HEALTH AND DISEASES. THE WORKFLOW RELIES ON A RAPID AND RELIABLE CONFOCAL MICROSCOPE SYSTEM, CAPABLE OF IMAGING THICK AND LARGE SAMPLES. TECHNOLOGY CURRENTLY AVAILABLE TO THE LABORATORY IS AGING, INCOMPATIBLE FOR IMAGING BIOMATERIALS, REQUIRES ADVANCE SCHEDULING, AND NECESSITATES PAYING COSTLY USER FEES. THE STATE-OF-THE-ART, STREAMLINED, AND SINGLE LABORATORY CONFOCAL MICROSCOPY SYSTEM REQUESTED HERE WILL PERMIT A MORE RAPID ADVANCE TOWARD THE PROJECT GOALS. THE SUPPLEMENT FUND IS REQUESTED FROM NIGMS TO COVER 65% OF THE SYSTEM COST. THE REMAINING 35% WILL BE CONTRIBUTED BY THE UNIVERSITY OF NOTRE DAME AS INSTITUTIONAL SUPPORT.
Department of Health and Human Services
$1.8M
SELECTIVE INHIBITION OF GRP 94 TO TREAT OCULAR HYPERTENSION AND GLAUCOMA - PROJECT SUMMARY THE ACCUMULATION OF MUTANT MYOCILLIN LEADS TO DECREASED AQUEOUS HUMOR OUTFLOW AND RESULTS IN ER DYSFUNCTION. GRP94 IS A MAJOR CHAPERONE LOCALIZED TO THE ER THAT IS RESPONSIBLE FOR MODULATING ER STRESS AND THE FOLDING OF SELECT CLIENT PROTEINS TO MAINTAIN PROTEOSTASIS. THROUGH A NUMBER OF KEY STUDIES, IT HAS BEEN SHOWN THAT GRP94 ATTEMPTS TO FOLD MUTANT MYOCILLIN, BUT INSTEAD CO-AGGREGATES AND CREATES A TOXIC GAIN OF FUNCTION FOR GRP94 THAT RESULTS IN POAG. RECENTLY, WE DISCOVERED GRP94 SELECTIVE INHIBITORS AND DEMONSTRATED BOTH IN VITRO AND IN VIVO THAT THEY REDUCED AGGREGATION AND RESTORE INTRAOCULAR PRESSURE, PROVIDING A NEW MECHANISM FOR THE TREATMENT OF POAG. THEREFORE, WE PROPOSE IN THIS APPLICATION TO OPTIMIZE OUR LEAD COMPOUNDS, DETERMINE THEIR MECHANISM OF ACTION, AND PROVIDE ADDITIONAL DATA TO SUPPORT THEIR DEVELOPMENT AS TOPICALLY ADMINISTERED THERAPEUTICS NOT ONLY FOR POAG, BUT ALSO STEROID-INDUCED GLAUCOMA.
National Science Foundation
$1.8M
DIANA, AN UNDERGROUND ACCELERATOR FACILITY FOR NUCLEAR ASTROPHYSICS
National Science Foundation
$1.8M
CCI PHASE I: NSF CENTER FOR COMPUTER ASSISTED SYNTHESIS
Department of Energy
$1.8M
TAS::89 0321::TAS CDP TO NOTRE DAME UNIVERSITY FOR PASSIVE NOX REMOVAL CATALYST RESEARCH.
National Science Foundation
$1.8M
DISCIPLINARY IMPROVEMENTS: THE SEEKCOMMONS RESEARCH COORDINATION NETWORK -THE ?SOCIO-ENVIRONMENTAL KNOWLEDGE COMMONS? (SEEKCOMMONS) RESEARCH COORDINATION NETWORK WILL DISSEMINATE AND STUDY OPEN SCIENCE TOOLS AND METHODOLOGIES TO ADVANCE COLLABORATIVE SOCIO-ENVIRONMENTAL RESEARCH. SEEKCOMMONS WILL BUILD BRIDGES BETWEEN DOMAINS OF SCIENTIFIC, TECHNICAL, AND ENVIRONMENTAL EXPERTISE THROUGH COMMUNITY-BUILDING WORKSHOPS AND SUPPORT ACTIVITIES THAT ENABLE THE SHARING OF SKILLS, RESOURCES, AND SOCIO-ENVIRONMENTAL RESEARCH PRODUCTS AS PUBLIC GOODS. THE PROJECT SEEKS TO BRIDGE LONG-STANDING DIVIDES BETWEEN THE SOCIAL AND ENVIRONMENTAL SCIENCES THROUGH THE ADAPTATION AND APPLICATION OF OPEN TOOLS AND METHODOLOGIES IN WAYS THAT WILL OVERCOME DISCIPLINARY BARRIERS TO ACCEPTANCE. SEEKCOMMONS WILL DRAW PRIMARILY FROM THREE AREAS OF RESEARCH AND DEVELOPMENT: SCIENCE AND TECHNOLOGY STUDIES (STS), OS, AND SOCIO-ENVIRONMENTAL RESEARCH. EACH OF THESE COMPONENT AREAS WILL BE INTEGRATED AND COORDINATED WITH THE OTHERS BY USING STS AS A ?TRANSLATIONAL COMPONENT? THAT WILL MEDIATE BETWEEN OPEN SCIENCE PRACTITIONERS AND SOCIO-ENVIRONMENTAL RESEARCHERS WORKING WITH COMMUNITIES AFFECTED BY ENVIRONMENTAL AND CLIMATE ISSUES. FIVE MAJOR ACTIVITIES WILL BE CONDUCTED TO ESTABLISH THE SEEKCOMMONS RCN: (1) EMPIRICAL STS RESEARCH ON COMMON PROBLEMS AND CAPACITY GAPS RELATED TO ?OPENNESS? IN SOCIO-ENVIRONMENTAL RESEARCH; (2) REGULAR CONVENINGS TO SHARE RESEARCH FINDINGS AND CHALLENGES, AND TO BUILD CONSENSUS ON HOW TO ADVANCE COLLABORATIVE WORK; (3) FELLOWSHIPS FOR STUDENTS AND EARLY-CAREER RESEARCHERS TO INVESTIGATE EMERGING PROBLEMS AND OPPORTUNITIES IN THE APPLICATION OF OS TO SOCIO-ENVIRONMENTAL RESEARCH; (4) A DATA FACILITATION CONSORTIUM; AND (5) CREATION OF A RESOURCE HUB AND CURRICULUM BUILDER TO DISSEMINATE OPEN RESEARCH OUTPUTS AND HIGHLIGHT THE WORK OF OUR NETWORK PARTNERS. THIS AWARD BY THE OFFICE OF ADVANCED CYBERINFRASTRUCTURE IS JOINTLY SUPPORTED BY THE DIRECTORATE FOR SOCIAL, BEHAVIORAL AND ECONOMIC SCIENCES. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.
Department of Health and Human Services
$1.8M
ENGINEERING THE NEXT GENERATION OF SAFER HSP90 INHIBITORS - SUMMARY: HSP90 IS A MOLECULAR CHAPERONE THAT IS RESPONSIBLE FOR THE CONFORMATIONAL MATURATION OF SIGNALING PROTEINS ASSOCIATED WITH ALL TEN HALLMARKS OF CANCER, MAKING IT A PROMISING TARGET FOR THE TREATMENT OF CANCER, AS MULTIPLE SIGNALING NODES CAN BE SIMULTANEOUSLY DERAILED AS A CONSEQUENCE OF HSP90 INHIBITION. MOREOVER, RESEARCHERS HAVE SHOWN THAT HSP90 INHIBITORS ACCUMULATE IN TUMORS WITH HIGH DIFFERENTIAL SELECTIVITY, MAKING HSP90 A HIGHLY SOUGHT AFTER TARGET FOR CANCER. UNFORTUNATELY, CLINICAL TRIALS WITH 17 SMALL MOLECULE INHIBITORS HAVE LED TO MULTIPLE DETRIMENTS THAT HAVE SIGNIFICANTLY DAMPENED ENTHUSIASM FOR HSP90 INHIBITORS, AS INCREASED LEVELS OF HSP90 WERE OBSERVED IN THE CLINIC, WHICH LED TO DOSE-ESCALATING TOXICITIES AMONG OTHER CONCERNS. CONSEQUENTLY, HSP90 REMAINS A DESIRABLE TARGET FOR THE DEVELOPMENT OF CANCER CHEMOTHERAPEUTICS, BUT NEW APPROACHES TO INHIBIT THE PROTEIN MACHINERY ARE NEEDED THAT DO NOT INDUCE HSP90 LEVELS. THROUGH A NUMBER OF SEMINAL STUDIES, IT HAS BEEN SHOWN THAT INHIBITORS OF THE HSP90 C-TERMINAL DOMAIN CAN SEGREGATE HSP90 INHIBITION FROM INDUCTION OF HSP90 LEVELS, AND THEREFORE, WE PROPOSE IN THIS APPLICATION TO OPTIMIZE THESE COMPOUNDS AND TO PERFORM A NUMBER OF PRE-IND STUDIES ON THE BEST MOLECULES IN AN EFFORT TO MOVE THEM TOWARD CLINICAL EVALUATION.
Department of Health and Human Services
$1.8M
NON-COVALENT MOLECULAR RECOGNITION FOR DRUG TARGETING IN THE BODY
Department of Health and Human Services
$1.8M
PATHOPHYSIOLOGIES INVOLVING HEMOSTASIS-RELATED GENES
Department of Energy
$1.8M
MULTI-SCALE SEPARATION AND ANALYSIS OF HETEROGENEOUS TRINITE PHASES ANTONIO SIMONETTI, P.I.
Department of Health and Human Services
$1.8M
PROTEOSTATIC MECHANISMS OF RESISTANCE IN MALARIA
Department of Health and Human Services
$1.8M
GENERATION OF NOVEL MODELS OF KIDNEY DEFECTS USING THE ZEBRAFISH
Department of Health and Human Services
$1.7M
MOLECULAR DIAGNOSTICS USING A NANOPORE TO ANALYZE SECRETIONS FROM SINGLE CELLS
Department of Energy
$1.7M
TOPOLOGICAL STRUCTURAL RELATIONSHIPS, PROPERTIES, AND NANO-STRUCTURES...
Department of Agriculture
$1.7M
** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** FOOD ACCESS IS AN UNFORTUNATE BUT VERY REAL PROBLEM FOR THE MANY AMERICANS THAT LIVE IN FOOD DESERTS WHERE THE COMBINATION OF DISTANCE TO FULL SERVICE SUPERMARKETS AND ACCESS TO TRANSPORTATION MAKES HEALTHY, AFFORDABLE FOOD LESS ATTAINABLE. TODAY'S TECHNOLOGICAL INNOVATIONS HAVE THE POTENTIAL TO ADDRESS THIS PROBLEM, HOWEVER THEY MUST BE ADAPTED TO APPLY TO THE CHALLENGING SOCIO-ECONOMIC CONDITIONS OF THESE COMMUNITIES. THE PROPOSED WORK WILL EXPLORE THE DEVELOPMENT OF HETEROGENEOUS NETWORK MODELS, INFORMATION VISUALIZATION, AND DELIVERY SERVICES FOR ADDRESSING THE PROBLEM OF FOOD ACCESS IN TWO LOW-INCOME COMMUNITIES IN SOUTH BEND, INDIANA AND DETROIT, MICHIGAN. THE PROPOSED WORK WILL DEEPLY INTEGRATE SOCIAL RESEARCH WITH TECHNOLOGICAL INNOVATION IN A USER-CENTERED DESIGN-THINKING FRAMEWORK IN ORDER TO IDENTIFY, UNDERSTAND, AND MEET THE NEEDS OF THE COMMUNITY STAKEHOLDERS. IN PARTICULAR THE PROPOSED WORK ADDRESSES FOUR OVERARCHING QUESTIONS:WHAT ARE THE CRITICAL-USER NEEDS FOR A TECHNOLOGY-ENABLED FOOD RECOMMENDER AND ACCESS SYSTEM?HOW DO WE MODEL THE COMPLEX FOOD INFORMATION LANDSCAPE AND MAKE CONTEXT-RELEVANT RECOMMENDATIONS FOR TARGET USERS LIVING UNDER THE CONSTRAINTS OF POVERTYHOW DO WE PRESENT ACCESSIBLE EXPLANATIONS OF RECOMMENDATIONS MADE OVER THIS COMPLEX LANDSCAPE OF DETERMINANTS INCLUDING, FOR EXAMPLE, PREFERENCE, COST, AND NUTRITIONAL VALUE.HOW FEASIBLE IS A DELIVERY HUB MODEL FOR ADDRESSING BRIDGING THE PHYSICAL ACCESS GAP?THROUGH A SERIES OF ITERATIVE USE RESEARCH AND DESIGN/DEVELOPMENT ACTIVITIES WITH COMMUNITY PARTNERS AND COMMUNITY MEMBERS, THE PROJECT WILL DEVELOP A PROTOTYPE RECOMMENDATION ENGINE THAT TAKES INTO ACCOUNT THE BROADER CONTEXT OF POVERTY TO MAKE STAKEHOLDER-RELEVANT RECOMMENDATIONS FOR MEAL PLANNING. THIS SYSTEM WILL BE EVALUATED USING A MIXED METHODS APPROACH TO UNDERSTAND THE EFFECTS OF THE INTERVENTION ON HEALTHY FOOD CHOICE.
Department of Health and Human Services
$1.7M
MITOPHAGY-MEDIATED CELL DEATH IN MAMMARY TUMORIGENESIS - PROJECT SUMMARY BACKGROUND: THE METASTASIS OF CANCEROUS CELLS TO DISTANT AND VITAL ORGANS IS RESPONSIBLE FOR IN EXCESS OF 90% OF CANCER MORTALITIES. GIVEN THIS EXTRAORDINARILY HIGH MORTALITY RATE, THERE IS A SIGNIFICANT NEED FOR THE DEVELOPMENT OF NOVEL THERAPEUTIC APPROACHES THAT EITHER ELIMINATE METASTATIC CANCER CELLS OR ERADICATE INCIPIENT CANCER CELLS PRIOR TO METASTATIC DISSEMINATION. AN IMPORTANT BARRIER TO TUMOR PROGRESSION AND METASTASIS IS ANOIKIS, A CASPASE- DEPENDENT CELL DEATH PROGRAM INDUCED BY LOSS OF INTEGRIN-MEDIATED ATTACHMENT TO EXTRACELLULAR MATRIX (ECM). HOWEVER, IT HAS BECOME CLEAR THAT ECM-DETACHMENT CAN INDUCE ANOIKIS-INDEPENDENT MECHANISMS THAT CAN COMPROMISE CELL VIABILITY. MORE SPECIFICALLY, WE HAVE DISCOVERED THAT DETACHMENT OF NON-CANCEROUS EPITHELIAL CELLS FROM ECM TRIGGERS A SIGNIFICANT ELEVATION IN THE LEVELS OF REACTIVE OXYGEN SPECIES (ROS) WHICH COMPROMISES CELL SURVIVAL IN AN ANOIKIS-INDEPENDENT FASHION. THE UNDERSTANDING OF THE CELLULAR CHANGES THAT CONTRIBUTE TO THE ELEVATION OF ROS DURING ECM-DETACHMENT REMAINS RUDIMENTARY AND THE STRATEGIES UTILIZED BY CANCER CELLS TO COMBAT ROS DURING ECM-DETACHMENT ARE INSUFFICIENTLY EXPLORED. THEREFORE, THESE POINTS REPRESENT SIGNIFICANT KNOWLEDGE GAPS THAT THIS GRANT PROPOSAL AIMS TO ADDRESS. DISCERNMENT OF MECHANISTIC INFORMATION REGARDING THE LINKS BETWEEN ECM-DETACHMENT, ROS, AND CELL SURVIVAL COULD PROVIDE TARGETS FOR THE DESIGN OF THE THERAPEUTIC APPROACHES AIMED AT SPECIFICALLY ELIMINATING ECM-DETACHED CANCER CELLS; AN OUTCOME THAT MAY HAVE SIGNIFICANT IMPACT FOR PATIENTS WITH METASTATIC DISEASE. OBJECTIVE/HYPOTHESIS: IN AGGREGATE, OUR PRELIMINARY STUDIES HAVE UNVEILED A NOVEL CELL DEATH MECHANISM (WITH A TUMOR SUPPRESSIVE FUNCTION) THAT COMPROMISES THE VIABILITY OF ECM-DETACHED CELLS: THE INDUCTION OF MITOPHAGY AS CONSEQUENCE OF RIPK1 SIGNALING. AS SUCH, THESE DATA HAVE MOTIVATED OUR CENTRAL HYPOTHESIS THAT RIPK1- MEDIATED MITOPHAGY DURING ECM-DETACHMENT FUNCTIONS AS A BARRIER TO BREAST CANCER PROGRESSION. SPECIFIC AIM I: TO ELUCIDATE THE MOLECULAR MECHANISM BY WHICH ECM-DETACHMENT PROMOTES RIPK1-DEPENDENT MITOPHAGY AND INITIATES CELL DEATH. SPECIFIC AIM II: TO ASSESS THE CAPACITY OF RIPK1-MEDIATED MITOPHAGY TO ANTAGONIZE TUMOR FORMATION IN VIVO AND TO EVALUATE ANTIOXIDANT INHIBITION AS A NOVEL STRATEGY TO LIMIT TUMORIGENESIS IN CANCERS THAT ARE DEFICIENT IN RIPK1-MEDIATED MITOPHAGY ANTICIPATED OUTCOMES: FOLLOWING THE COMPLETION OF THESE STUDIES, WE WILL HAVE ACCUMULATED SIGNIFICANT MECHANISTIC KNOWLEDGE REGARDING THE RELATIONSHIP BETWEEN ECM-DETACHMENT, RIPK1 MITOPHAGY, AND CELL DEATH. THUS, THE COMPLETION OF THESE STUDIES WILL UNVEIL FUNDAMENTAL BIOLOGICAL INSIGHTS REGARDING CANCER CELL SURVIVAL DURING ECM-DETACHMENT THAT MAY ULTIMATELY LEAD TO THE DEVELOPMENT OF THERAPEUTIC APPROACHES TO LIMIT THE DISSEMINATION OF BREAST CANCER CELLS.
Department of Health and Human Services
$1.7M
ESTABLISHING AN IMMUNE MECHANOME - ABSTRACT MECHANICAL FORCES ARE OFTEN MODULATED IN DISEASED OR WOUNDED TISSUES AS A RESULT OF INFLAMMATORY RESPONSES DRIVEN BY IMMUNE CELL ACTIVITY IN THE AFFECTED SITE(S). IN FACT, ABERRANT MECHANICAL FORCE GENERATION IN PATHOLOGICAL SETTINGS MAY MEDIATE DISEASE PROGRESSION AND TREATMENT RESISTANCE. HOWEVER, LITTLE IS KNOWN ABOUT THE RESPONSE OF IMMUNE CELLS TO THESE MECHANICAL FORCES, PARTICULARLY AT THE TISSUE-LENGTH SCALE, AND EVEN IN NORMAL PHYSIOLOGICAL SETTINGS. THUS THERE IS A CRITICALLY UNMET NEED TO FILL OVERLOOKED GAPS IN OUR BASIC UNDERSTANDING OF THE INTERPLAY BETWEEN TISSUE-LEVEL MECHANICAL FORCES AND IMMUNE CELL BEHAVIOR, BOTH COLLECTIVELY AND AT THE SINGLE-CELL LEVEL. WITH THE SUPPORT OF THE NIGMS R35 MIRA FOR EARLY STAGE INVESTIGATORS OVER THE NEXT FIVE YEARS, MY LABORATORY WILL ESTABLISH THE FIRST IMMUNE MECHANOME. WE WILL INVESTIGATE THE IMPACT OF TISSUE MECHANICAL FORCES ON THE PHENOTYPE AND FUNCTION OF INNATE AND ADAPTIVE IMMUNE CELLS IN A VARIETY OF ORGANS. LEVERAGING ENGINEERING-BASED TOOLS AND APPROACHES, WE WILL COUPLE UNBIASED OMICS PLATFORMS TO MECHANICAL TESTING AT MULTIPLE SCALES (E.G., ON CELLS IN VIVO, TISSUES EX VIVO, AND ORGANS IN VIVO) IN ORDER TO RELATE IMMUNE RESPONSE TO MECHANICAL FORCES. DURING MULTISCALE COMPRESSION, THE TRAFFICKING, DISTRIBUTION, MOTILITY, CELL-CELL INTERACTIONS, AND FUNCTIONAL BEHAVIOR OF IMMUNE CELLS WILL BE EXAMINED AND PERTURBED VIA: I) INTRAVITAL AND DYNAMIC IMAGING (E.G., WITH MULTIPHOTON MICROSCOPY OF FLUORESCENT CELLS OR GENETICALLY ENGINEERED MOUSE MODELS); II) IMMUNOCOMPETENT, TRANSGENIC, AND IMMUNOGENIC ANIMAL MODELS (E.G., OT-I/OT-II ANTIGEN SYSTEMS); AND III) ARTIFICIAL INTELLIGENCE- BASED CELL STATE ANALYSIS (E.G., FROM SINGLE CELL RNA SEQUENCING). WE WILL ALSO EXPLORE OUR HYPOTHESIS THAT BENEFICIAL IMMUNE ACTIVITY IN THE FACE OF PATHOLOGICAL CONDITIONS IS SUPPRESSED BY HEIGHTENED TISSUE MECHANICAL FORCES. IMPORTANTLY, THE PROPOSED PROJECTS ARE TO BE PERFORMED IN NON-SPECIFIC CONTEXTS THAT ARE INDEPENDENT OF TISSUE TYPE, ORGAN, OR DISEASE IN ORDER TO MAXIMIZE THE POTENTIAL FOR BROAD IMPACT IN THE BIOMEDICAL SCIENCES. THE KNOWLEDGE GENERATED WILL LAY THE GROUNDWORK FOR FUTURE MECHANISTIC AND TRANSLATIONAL RESEARCH IN BOTH HEALTHY AND DISEASED SETTINGS. BY OPERATING AT THE INTERFACE OF MECHANICAL ENGINEERING AND IMMUNOLOGY IN THE BURGEONING FIELD OF “MECHANO-IMMUNOLOGY,” MY RESEARCH PROGRAM IS UNIQUELY SUITED TO REVEAL NEW BIOPHYSICAL INSIGHTS AND PATHOPHYSIOLOGICAL TARGETS FOR HUMAN DISEASE.
Department of Health and Human Services
$1.7M
DEVELOPMENT AND EVALUATION OF PURINE AND COUMARIN BASED HSP90 INHIBITORS
National Science Foundation
$1.7M
STRUCTURAL EXTREME EVENTS RECONNAISSANCE (STEER): DATA TO KNOWLEDGE FRAMEWORK FOR COORDINATED RECONNAISSANCE FOLLOWING NATURAL HAZARD EVENTS
Department of Energy
$1.6M
MOLECULAR ASPECTS OF TRANSPORT IN THIN FILMS OF CONTROLLLED ARCHITECTURE
Department of Defense
$1.6M
MASTERS AND STEM PROGRAMS IN HYPERSONIC SYSTEMS
National Aeronautics and Space Administration
$1.6M
EXECUTE A BALANCED SCIENCE PROGRAM BASED ON DISCIPLINE-SPECIFIC GUIDANCE FROM THE NATIONAL ACADEMIES OF SCIENCES ENGINEERING AND MEDICINE ADMINISTRATION PRIORITIES AND DIRECTION FROM CONGRESS. PARTICIPATE AS A KEY PARTNER AND ENABLER IN THE AGENCY S EXPLORATION INITIATIVE FOCUSING ON SCIENTIFIC RESEARCH OF ON AND FROM THE MOON LUNAR ORBIT MARS AND BEYOND. ADVANCE DISCOVERY IN EMERGING FIELDS BY IDENTIFYING AND EXPLOITING CROSS-DISCIPLINARY OPPORTUNITIES BETWEEN TRADITIONAL SCIENCE DISCIPLINES. DEVELOP A DIRECTORATE-WIDE TARGET-USER FOCUSED APPROACH TO APPLIED PROGRAMS INCLUDING EARTH SCIENCE APPLICATIONS SPACE WEATHER PLANETARY DEFENSE AND SPACE SITUATIONAL AWARENESS
National Science Foundation
$1.6M
NEB: PHYSICS-INSPIRED NON-BOOLEAN COMPUTATION BASED ON SPATIAL- TEMPORAL WAVE EXCITATIONS
National Science Foundation
$1.6M
COLLABORATIVE RESEARCH AND NEON: MSB CATEGORY 2: PALEON - A PALEOECOLOGICAL OBSERVATORY NETWORK TO ASSESS TERRESTRIAL ECOSYSTEM MODELS
Department of Health and Human Services
$1.6M
QUANTITATIVE PROTEOMICS OF XENOPUS OOCYTES, EGGS, BLASTOMERES, AND NUCLEAR TRANSPLANTS
Department of Health and Human Services
$1.6M
AN ENGINEERED TISSUE MODEL OF AGED MAMMARY MICROENVIRONMENT
Department of Health and Human Services
$1.6M
MODEL-BASED INFERENCE AND FORECASTING OF CO-CIRCULATING PATHOGEN DYNAMICS - PROJECT SUMMARY PUBLIC HEALTH FACES THREATS FROM A MULTITUDE OF PATHOGENS ON AN ONGOING BASIS, YET PATHOGENS ASSOCIATED WITH DIFFERENT DISEASES ARE TYPICALLY COMPARTMENTALIZED WITH RESPECT TO SURVEILLANCE, MANAGEMENT, AND RESEARCH. THIS COMPARTMENTALIZED APPROACH IGNORES THE MANY WAYS THAT PATHOGENS INTERACT, IN SOME CASES LEADING TO THE EXACERBATION OF THEIR COLLECTIVE BURDEN ON PUBLIC HEALTH. THESE INTERACTIONS CAN BE BIOLOGICAL (E.G., CROSS-REACTIVE IMMUNITY), BEHAVIORAL (E.G., PROMPTING ADHERENCE TO GOOD HYGIENE), OR CLINICAL (E.G., MISDIAGNOSIS). MODERN, DATA- DRIVEN APPROACHES TO MATHEMATICAL MODELING HAVE THE POTENTIAL TO RESOLVE THE DYNAMICS OF CO- CIRCULATING PATHOGENS BY ACCOUNTING FOR THESE INTERACTIONS. IN DOING SO, MODELING ALSO HAS THE POTENTIAL TO IMPROVE PATHOGEN-SPECIFIC DISEASE FORECASTS BY BORROWING INFORMATION ACROSS SURVEILLANCE DATA FOR DIFFERENT DISEASES. TO DATE, THIS POTENTIAL REMAINS LARGELY UNTAPPED. IN THIS PROJECT, I WILL DEVELOP A GENERALIZABLE FRAMEWORK FOR MODELING THE DYNAMICS OF CO-CIRCULATING PATHOGENS. THE FIRST COMPONENT OF THIS FRAMEWORK WILL USE BAYESIAN HIERARCHICAL MODELING TO FUSE MECHANISTIC DESCRIPTIONS OF PATHOGEN TRANSMISSION DYNAMICS WITH STATISTICAL DESCRIPTIONS OF SURVEILLANCE PROCESSES, ALLOWING FOR MAXIMAL LEVERAGING OF HETEROGENEOUS DATA STREAMS TO INFORM BIOLOGICAL INFERENCES. THE SECOND COMPONENT OF THIS FRAMEWORK WILL INVOLVE VALIDATING MODEL INFERENCES THROUGH FORECASTS OF FUTURE DISEASE DYNAMICS. BOTH COMPONENTS OF THIS FRAMEWORK WILL INVOLVE THE USE OF MULTIPLE MODELS THAT REPRESENT COMPETING HYPOTHESES ABOUT PATHOGEN INTERACTION, AS WELL AS OTHER FORMS OF MODEL UNCERTAINTY. THIS FRAMEWORK WILL BE APPLIED IN TWO SETTINGS: MOSQUITO-BORNE VIRUSES IN BRAZIL AND RESPIRATORY PATHOGENS IN INDIANA. IN BOTH OF THESE SETTINGS, CO-CIRCULATION OF RECENTLY EMERGED AND ENDEMIC PATHOGENS POSES NEW CHALLENGES FOR SURVEILLANCE AND CONTROL ACTIVITIES, MAKING THE DEVELOPMENT OF NEW MODELING TOOLS TO ADDRESS THESE CHALLENGES ESPECIALLY TIMELY.
Department of Health and Human Services
$1.6M
HOST AND FUNGAL FACTORS IMPORTANT FOR THE CRYPTOCOCCAL INTRACELLULAR NICHE - PROJECT SUMMARY / ABSTRACT UNDERSTANDING HOW INTRACELLULAR PATHOGENS SURVIVE IN THEIR HOST CELLS HAS LED TO BETTER MANAGEMENT/PRE- VENTION OF THEIR DISEASES, AS WELL AS DISCOVERY OF FUNDAMENTAL BIOLOGY. IN THIS APPLICATION, WE AIM TO START ELUCIDATING THE STRATEGIES AND MECHANISMS USED BY ONE OF THE COMMONEST FUNGAL PATHOGENS, CRYPTOCOCCUS NEOFORMANS, TO SURVIVE INSIDE MACROPHAGES. THE TREATMENT OF CRYPTOCOCCAL DISEASE IS SUBPAR, RESULTING IN MOR- TALITIES THAT RANGE FROM 20% TO ALMOST 90%, DEPENDING ON THE GEOGRAPHICAL REGION. THE ABILITY OF THIS FUNGUS TO SURVIVE INSIDE HOST CELLS IS ONE OF THE MAIN DRIVERS OF DISEASE PROGRESSION, AND CLINICAL STUDIES SHOW THAT INTRA- CELLULAR SURVIVAL IN MACROPHAGES CORRELATES WITH PATIENT’S MORTALITY. HOWEVER, THE MOLECULAR MECHANISMS THAT GOVERN INTERNALIZATION AND THE ABILITY TO SURVIVE INTRACELLULARLY ARE NOT KNOWN, HAMPERING THE DEVELOPMENT OF MORE EFFECTIVE THERAPEUTICS. OUR LONG-TERM GOAL IS TO UNDERSTAND THE CELLULAR AND MOLECULAR MECHANISMS BEHIND INTRA- CELLULAR SURVIVAL, A SIGNIFICANT GAP IN KNOWLEDGE IN THE FIELD. MOVING TOWARDS THAT GOAL, THE OBJECTIVES OF THIS APPLICATION ARE TO DEFINE AND CHARACTERIZE THE CRYPTOCOCCAL-CONTAINING PHAGOSOME (CCP) IN MACROPHAGES, AND UNDERSTAND THE ROLE OF HOST AND FUNGAL FACTORS IN THE GENERATION OF THIS INTRACELLULAR NICHE. WE HYPOTHESIZE THAT CRYPTOCOCCUS ACTIVELY TARGETS RAB GTPASES AND PHOSPHOINOSITIDES TO DELAY THE NORMAL MATURATION OF ITS PHAG- OSOME. THIS ALLOWS FUNGAL FACTORS, SUCH AS CAPSULAR HYALURONIC ACID AND GLUCURONIC ACID, TO MODULATE ACIDIFICATION OF THE CCP, RESULTING IN A FUNGAL PERMISSIVE NICHE. PRO-INFLAMMATORY SIGNALS, MEDIATED IN PART BY RAB20 EFFECTS ON PHAGOSOMAL MATURATION, COUNTER THIS FUNGAL MANIPULATION AND PREVENT NICHE ESTABLISHMENT. WE PLAN TO TEST THIS HYPOTHESIS BY (1) DEFINING AND CHARACTERIZING THE INTRACELLULAR NICHE OF C. NEOFORMANS IN NAÏVE AND ACTIVATED MACROPHAGES; AND (2) IDENTIFY AND EXPLORE THE ROLE OF FUNGAL FACTORS IN NICHE ESTABLISHMENT. IF COMPLETED, WE WILL HAVE IDENTIFIED THE GENETIC (FUNGAL GENES), PHENOTYPIC (CCP PROPERTIES) AND IMMUNOLOGICAL (HOST’S IMMUNE STA- TUS) CHARACTERISTICS THAT ENABLE CRYPTOCOCCUS TO LIVE INTRACELLULARLY, ALLOWING US TO PINPOINT POTENTIAL AREAS OF INTERVENTION TO BLOCK INTRACELLULAR REPLICATION. COMPLETION OF THESE AIMS WILL HAVE A POSITIVE IMPACT IN THE FIELD BY GENERATING A DETAILED MOLECULAR DESCRIPTION OF THE STRATEGIES CRYPTOCOCCUS USES TO SURVIVE IN MACROPHAGES AND HOW HOST CELLS RESPOND. MOREOVER, GIVEN THE SCARCITY OF WELL CHARACTERIZED INTRACELLULAR SURVIVAL STRATEGIES IN FUNGI, THE KNOWLEDGE CREATED HERE WILL IMPACT THE UNDERSTANDING AND STUDIES OF OTHER PATHOGENIC FUNGI AS WELL.
Department of Defense
$1.6M
OVERCOMING BREAST CANCER METASTASIS TO BONE BY CXCR2 INHIBITION
National Science Foundation
$1.6M
CDI-TYPE II: BUILDING AND STUDYING A VIRTUAL ORGANIZATION FOR ADAPTATION TO CLIMATE CHANGE
National Science Foundation
$1.6M
NEB: NANOELECTRONICS WITH MIXED-VALENCE MOLECULAR QCA
Department of Health and Human Services
$1.5M
CHEMISTRY-BIOCHEMISTRY-BIOLOGY INTERFACE (CBBI) PROGRAM AT NOTRE DAME - ABSTRACT THE CHEMISTRY-BIOCHEMISTRY-BIOLOGY INTERFACE (CBBI) PROGRAM AT THE UNIVERSITY OF NOTRE DAME IS AN ESTABLISHED NIH-FUNDED PROGRAM THAT SUPPORTS THE TRAINING OF DIVERSE POOL OF SCIENTISTS WHO CONDUCT MULTIDISCIPLINARY RESEARCH AT THE INTERFACE OF CHEMISTRY AND BIOLOGY-RELATED DISCIPLINES. THE GOAL OF THE CBBI PROGRAM IS TO PRODUCE PHD SCIENTISTS WHO WORK EFFECTIVELY AT THE INTERFACE OF CHEMISTRY AND BIOLOGY AND WHO ARE ABLE TO SPEAK THE LANGUAGE OF TWO OR MORE DISCIPLINES. THE CBBI PROGRAM HAS ESTABLISHED AN OUTSTANDING TRAINING ENVIRONMENT FOR OUR PREDOCTORAL TRAINEES. SINCE 2007 WE HAVE TRAINED 84 STUDENTS, 57 OF WHOM HAVE COMPLETED PHD DEGREES IN AN AVERAGE OF 5.14 YEARS (TIME TO PHD DEGREE FROM CBBI TRAINEES IS 4.98 IN THE PAST 10 YEARS) WITH 19 STILL IN TRAINING. OF THESE 84, 16 ARE UNDERREPRESENTED MINORITIES (URMS), 10 OF WHOM HAVE ALREADY RECEIVED PHD DEGREES. OUR 84 TRAINEES HAVE 362 PUBLICATIONS, OF WHICH 159 ARE FIRST-AUTHOR PUBLICATIONS. THIS REPRESENTS 4.3 PUBLICATIONS PER TRAINEE AND 1.9 FIRST-AUTHOR PUBLICATIONS PER TRAINEE. THE 16 URMS HAVE PRODUCED 79 PUBLICATIONS, OF WHICH 31 ARE FIRST-AUTHOR PUBLICATIONS; THIS REPRESENTS 4.9 PUBLICATIONS PER URM AND 1.9 FIRST- AUTHOR PUBLICATIONS PER URM. DURING THE PAST 14 YEARS, OUR ATTRITION RATE HAS BEEN LOW, WITH ONLY EIGHT OF 84 TRAINEES (9.5%) WHO DID NOT COMPLETE A PHD DEGREE. THE KEY HIGHLIGHTS OF THE CBBI PROGRAM ARE: 1) A LARGE AND DIVERSE POOL OF HIGHLY QUALIFIED CANDIDATES; 2) A STRONG TRACK RECORD OF COLLABORATIVE AND MULTIDISCIPLINARY RESEARCH BY BOTH TRAINEES AND MENTORS; 3) A DIVERSE FACULTY GROUP THAT SERVES AS RESEARCH MENTORS AND ARE EXPERIENCED, PRODUCTIVE, AND FEDERALLY-FUNDED; 4) AN INTENSIVE, CROSS-DISCIPLINARY RESEARCH INTERNSHIP IN THE OTHER FIELD OUTSIDE THE MENTOR’S LABORATORY; 5) MULTIDISCIPLINARY SEMINARS THAT SUPPLEMENT TRAINING; 6) INDIVIDUAL AND GROUP MEETINGS WITH TRAINEES; 7) THE ANNUAL CBBI SYMPOSIUM THAT FEATURES BOTH ORAL AND POSTER PRESENTATIONS AT THE CHEMISTRY- BIOLOGY INTERFACE; 8) PROGRAM ADMINISTRATION WITH AN ESTABLISHED TRACK RECORD OF TRAINING STUDENTS AT THE CHEMISTRY- BIOLOGY INTERFACE; 9) A PLAN AND MECHANISM FOR CONTINUOUS EVALUATION AND REFINEMENT OF THE TRAINING PROGRAM; 10) PROFESSIONAL DEVELOPMENT AND CAREER PLACEMENT; 11) OUTSTANDING RESEARCH FACILITIES; AND 12) A STRONG INSTITUTIONAL COMMITMENT. WE PROPOSE TO CONTINUE TO TRAIN PHD SCIENTISTS WITH THE SKILLS AND EXPERTISE TO SOLVE CHALLENGING BIOMEDICAL PROBLEMS, REGARDLESS OF DISCIPLINE. THE UNIVERSITY OF NOTRE DAME ENTHUSIASTICALLY SUPPORTS THIS TRAINING PROGRAM, AND WILL CONTINUE TO PROVIDE A GENEROUS FELLOWSHIP MATCH TO THE CBBI PROGRAM AND ADDITIONAL RESOURCES, INCLUDING THE COST OF THE RESEARCH INTERNSHIP FOR ALL TRAINEES, UPON RENEWAL OF FUNDING BY THE NIH.
Source: Federal Audit Clearinghouse (fac.gov)
Years audited
10
Clean years
10
Material Weakness
No
Noncompliance Issues
No
| Year | Status | Financial Report | Federal Expenditurecombined across all audits filed that year | Low Risk | Accepted |
|---|---|---|---|---|---|
| 2025 | Clean | Unmodified (Clean) | $217.8M | Yes | 2026-03-20 |
| 2024 | Clean | Unmodified (Clean) | $213.8M | Yes | 2025-03-25 |
| 2023 | Clean | Unmodified (Clean) | $218.1M | Yes | 2024-03-22 |
| 2022 | Clean | Unmodified (Clean) | $194.9M | Yes | 2023-01-19 |
| 2021 | Clean | Unmodified (Clean) | $182.2M | Yes | 2022-03-29 |
| 2020 | Clean | Unmodified (Clean) | $182.9M | Yes | 2021-03-25 |
| 2019 | Clean | Unmodified (Clean) | $195.1M | Yes | 2020-03-19 |
| 2018 | Clean | Unmodified (Clean) | $194.8M | Yes | 2019-03-21 |
| 2017 | Clean | Unmodified (Clean) | $201.1M | Yes | 2018-03-06 |
| 2016 | Clean | Unmodified (Clean) | $198M | Yes | 2017-01-25 |
Financial Report
Unmodified (Clean)
Federal Expenditure, combined across all audits filed that year
$217.8M
Financial Report
Unmodified (Clean)
Federal Expenditure, combined across all audits filed that year
$213.8M
Financial Report
Unmodified (Clean)
Federal Expenditure, combined across all audits filed that year
$218.1M
Financial Report
Unmodified (Clean)
Federal Expenditure, combined across all audits filed that year
$194.9M
Financial Report
Unmodified (Clean)
Federal Expenditure, combined across all audits filed that year
$182.2M
Financial Report
Unmodified (Clean)
Federal Expenditure, combined across all audits filed that year
$182.9M
Financial Report
Unmodified (Clean)
Federal Expenditure, combined across all audits filed that year
$195.1M
Financial Report
Unmodified (Clean)
Federal Expenditure, combined across all audits filed that year
$194.8M
Financial Report
Unmodified (Clean)
Federal Expenditure, combined across all audits filed that year
$201.1M
Financial Report
Unmodified (Clean)
Federal Expenditure, combined across all audits filed that year
$198M
Tax Year 2023 · Source: IRS e-Filed Form 990Schedule J available
Individuals serving as officers, directors, or trustees of the organization.
| Name | Title | Hrs/Wk | Compensation | Related Orgs | Other |
|---|
Source: IRS Publication 78, Auto-Revocation List & e-Postcard Data
Tax-deductible contributions: Yes
Deductibility code: GROUP
990-N (e-Postcard) Filing History
This organization files simplified Form 990-N (annual gross receipts ≤ $50,000).
Sources: IRS e-Filed Form 990 (XML) & ProPublica Nonprofit Explorer
Scroll →
| Year | Revenue | Contributions | Expenses | Assets | Net Assets |
|---|---|---|---|---|---|
| 2023IRS e-File | $3.3B | $791.1M | $2.2B | $26.7B | $22.1B |
| 2022IRS e-File | $2.6B | $587.6M | $2B | $24.8B | $20.3B |
| 2021 | $3.5B | $466.3M | $1.7B | $26.3B | $21.5B |
| 2020 | $2.5B |
Sources: ProPublica Nonprofit Explorer & IRS e-File Index
Financial data: IRS e-Filed Form 990 (Tax Year 2023)
Leadership & compensation: IRS e-Filed Form 990, Part VII (Tax Year 2023)
Federal grants: USAspending.gov (live)
Organization info: IRS Business Master File
Tax-deductibility: IRS Publication 78
| Total |
|---|
| Michael D Donovan Jd Mba | VP & Chief Investment Officer | 40 | $3.9M | $0 | $42.4K | $3.9M |
| Rev John I Jenkins Csc Phd | President (until 5/31/24), Fellow & Trustee | 40 | $1.7M | $0 | $100.3K | $1.8M |
| Shannon B Cullinan Mba | Executive Vice President | 40 | $883.8K | $0 | $340.8K | $1.2M |
| John T Mcgreevy Phd | Provost | 40 | $832.2K | $0 | $124.8K | $957K |
| Marianne Corr Jd | VP & General Counsel | 40 | $891.2K | $0 | $46.5K | $937.8K |
| Rev Robert A Dowd Csc Mdiv Phd | President (as Of 6/1/24), Fellow & Trustee | 40 | $300.2K | $0 | $20.7K | $320.9K |
Michael D Donovan Jd Mba
VP & Chief Investment Officer
$3.9M
Hrs/Wk
40
Compensation
$3.9M
Related Orgs
$0
Other
$42.4K
Rev John I Jenkins Csc Phd
President (until 5/31/24), Fellow & Trustee
$1.8M
Hrs/Wk
40
Compensation
$1.7M
Related Orgs
$0
Other
$100.3K
Shannon B Cullinan Mba
Executive Vice President
$1.2M
Hrs/Wk
40
Compensation
$883.8K
Related Orgs
$0
Other
$340.8K
John T Mcgreevy Phd
Provost
$957K
Hrs/Wk
40
Compensation
$832.2K
Related Orgs
$0
Other
$124.8K
Marianne Corr Jd
VP & General Counsel
$937.8K
Hrs/Wk
40
Compensation
$891.2K
Related Orgs
$0
Other
$46.5K
Rev Robert A Dowd Csc Mdiv Phd
President (as Of 6/1/24), Fellow & Trustee
$320.9K
Hrs/Wk
40
Compensation
$300.2K
Related Orgs
$0
Other
$20.7K
Highest compensated employees who are not officers or directors.
| Name | Title | Hrs/Wk | Compensation | Related Orgs | Other | Total |
|---|---|---|---|---|---|---|
| Marcus L Freeman | Head Coach, Football | 40 | $7.4M | $0 | $61.8K | $7.4M |
| Micah W Shrewsberry | Head Coach, Men's Basketball | 40 | $3.2M | $0 | $55.3K | $3.3M |
| Timothy W Dolezal | Managing Director, Investment Office | 40 | $1.9M |
Marcus L Freeman
Head Coach, Football
$7.4M
Hrs/Wk
40
Compensation
$7.4M
Related Orgs
$0
Other
$61.8K
Micah W Shrewsberry
Head Coach, Men's Basketball
$3.3M
Hrs/Wk
40
Compensation
$3.2M
Related Orgs
$0
Other
$55.3K
Timothy W Dolezal
Managing Director, Investment Office
$2.8M
Hrs/Wk
40
Compensation
$1.9M
Related Orgs
$0
Other
$883.7K
Members of the governing board. Board members often serve without compensation.
| Name | Title | Hrs/Wk | Compensation | Related Orgs | Other | Total |
|---|---|---|---|---|---|---|
| Andrew J Mckenna Jr | Trustee | 2 | $0 | $0 | $0 | $0 |
| Anne E Thompson | Trustee | 2 | $0 | $0 | $0 | $0 |
| Byron O Spruell | Trustee | 3 | $0 | $0 | $0 | $0 |
| Carlos J Betancourt | Trustee | 2 | $0 | $0 | $0 | $0 |
| Cindy K Parseghian | Trustee | 2 | $0 | $0 | $0 | $0 |
| Clare Stack Richer | Trustee |
Andrew J Mckenna Jr
Trustee
$0
Hrs/Wk
2
Compensation
$0
Related Orgs
$0
Other
$0
Anne E Thompson
Trustee
$0
Hrs/Wk
2
Compensation
$0
Related Orgs
$0
Other
$0
Byron O Spruell
Trustee
$0
Hrs/Wk
3
Compensation
$0
Related Orgs
$0
Other
$0
Individuals who previously served as officers or key employees.
| Name | Title | Hrs/Wk | Compensation | Related Orgs | Other | Total |
|---|---|---|---|---|---|---|
| Marie Lynn Miranda Phd | Former Provost | 40 | $412.8K | $0 | $61.5K | $474.3K |
Marie Lynn Miranda Phd
Former Provost
$474.3K
Hrs/Wk
40
Compensation
$412.8K
Related Orgs
$0
Other
$61.5K
| $616.8M |
| $1.7B |
| $18.4B |
| $14.5B |
| 2019 | $2.1B | $431.8M | $1.7B | $17.3B | $13.7B |
| 2018 | $2.5B | $604.4M | $1.7B | $16.6B | $13.1B |
| 2017 | $2.1B | $472M | $1.5B | $14.9B | $11.8B |
| 2016 | $1.9B | $572M | $1.4B | $13.3B | $10.6B |
| 2015 | $2.2B | $577M | $1.4B | $13B | $10.7B |
| 2014 | $2B | $512.1M | $1.3B | $11.9B | $9.9B |
| 2013 | $1.6B | $323.3M | $1.2B | $10.3B | $8.3B |
| 2012 | $1.4B | $252.6M | $1.2B | $9.3B | $7.5B |
| 2011 | $1.4B | $313M | $1.1B | $9.1B | $7.6B |
| 2021 | 990 | Data |
| 2020 | 990 | Data |
| 2019 | 990 | Data |
| 2018 | 990 | Data |
| 2017 | 990 | Data |
| 2016 | 990 | Data |
| 2015 | 990 | Data |
| 2014 | 990 | Data |
| 2013 | 990 | Data |
| 2012 | 990 | Data |
| 2011 | 990 | Data |
| 2010 | 990 | — |
| 2009 | 990 | — |
| 2008 | 990 | — |
| 2007 | 990 | — |
| 2006 | 990 | — |
| 2005 | 990 | — |
| 2004 | 990 | — |
| 2003 | 990 | — |
| 2002 | 990 | — |
| 2001 | 990 | — |
| $0 |
| $883.7K |
| $2.8M |
| John B Swarbrick Jr Jd | VP & Director Of Athletics | 40 | $1.7M | $0 | $262.4K | $1.9M |
| Alfred J Golden | Defensive Coordinator, Football | 40 | $1.6M | $0 | $60.4K | $1.7M |
| Mark C Krcmaric Jd Mba | Managing Director & Chief Operating Officer, Investment Office | 0 | $1.4M | $0 | $34K | $1.4M |
John B Swarbrick Jr Jd
VP & Director Of Athletics
$1.9M
Hrs/Wk
40
Compensation
$1.7M
Related Orgs
$0
Other
$262.4K
Alfred J Golden
Defensive Coordinator, Football
$1.7M
Hrs/Wk
40
Compensation
$1.6M
Related Orgs
$0
Other
$60.4K
Mark C Krcmaric Jd Mba
Managing Director & Chief Operating Officer, Investment Office
$1.4M
Hrs/Wk
0
Compensation
$1.4M
Related Orgs
$0
Other
$34K
| 2 |
| $0 |
| $0 |
| $0 |
| $0 |
| Dorene C Dominguez | Trustee | 2 | $0 | $0 | $0 | $0 |
| J Christopher Reyes | Trustee | 3 | $0 | $0 | $0 | $0 |
| James C Parsons | Trustee | 2 | $0 | $0 | $0 | $0 |
| James F Flaherty Iii | Fellow & Trustee | 3 | $0 | $0 | $0 | $0 |
| James J Dunne Iii | Trustee | 3 | $0 | $0 | $0 | $0 |
| Jennifer F Scanlon | Trustee | 3 | $0 | $0 | $0 | $0 |
| John B Veihmeyer | Fellow & Trustee | 3 | $0 | $0 | $0 | $0 |
| John J Brennan | Fellow & Trustee | 4 | $0 | $0 | $0 | $0 |
| John J Coyle | Trustee | 2 | $0 | $0 | $0 | $0 |
| Justin R Liu | Trustee | 2 | $0 | $0 | $0 | $0 |
| Karen Mccartan Desantis | Trustee | 2 | $0 | $0 | $0 | $0 |
| Kathryn A Koch | Trustee | 2 | $0 | $0 | $0 | $0 |
| Kenneth C Ricci | Trustee | 3 | $0 | $0 | $0 | $0 |
| Lois K Folger | Trustee | 2 | $0 | $0 | $0 | $0 |
| Martin W Rodgers | Trustee | 2 | $0 | $0 | $0 | $0 |
| Michael G O'Grady | Trustee | 2 | $0 | $0 | $0 | $0 |
| Nathan O Hatch | Trustee | 2 | $0 | $0 | $0 | $0 |
| Paulita A Pike | Trustee | 2 | $0 | $0 | $0 | $0 |
| Phyllis W Stone | Trustee | 2 | $0 | $0 | $0 | $0 |
| Raul R Romero | Trustee | 2 | $0 | $0 | $0 | $0 |
| Rev Daniel G Groody Csc Mdiv Phd | VP & Associate Provost, Fellow & Trustee | 40 | $302.8K | $0 | $17.1K | $319.9K |
| Rev Gregory P Haake Csc Mdiv Phd | Associate Professor, Fellow & Trustee | 40 | $151.7K | $0 | $20.7K | $172.4K |
| Rev Jose E Ahumada F Csc | Trustee | 2 | $0 | $0 | $0 | $0 |
| Rev Thomas P Looney Csc | Fellow & Trustee | 2 | $0 | $0 | $0 | $0 |
| Rev William M Lies Csc | Fellow & Trustee | 2 | $0 | $0 | $0 | $0 |
| Sara Martinez Tucker | Fellow & Trustee | 3 | $0 | $0 | $0 | $0 |
| Scott A Dahnke | Trustee | 2 | $0 | $0 | $0 | $0 |
| Shayla Keough Rumely | Fellow & Trustee | 2 | $0 | $0 | $0 | $0 |
| Stephanie A Gallo | Trustee | 3 | $0 | $0 | $0 | $0 |
| Stephen J Brogan | Fellow & Trustee | 2 | $0 | $0 | $0 | $0 |
| Tanya M Kne | Trustee | 2 | $0 | $0 | $0 | $0 |
| Thomas G Maheras | Trustee | 3 | $0 | $0 | $0 | $0 |
| Tracy D Graham | Trustee | 2 | $0 | $0 | $0 | $0 |
Carlos J Betancourt
Trustee
$0
Hrs/Wk
2
Compensation
$0
Related Orgs
$0
Other
$0
Cindy K Parseghian
Trustee
$0
Hrs/Wk
2
Compensation
$0
Related Orgs
$0
Other
$0
Clare Stack Richer
Trustee
$0
Hrs/Wk
2
Compensation
$0
Related Orgs
$0
Other
$0
Dorene C Dominguez
Trustee
$0
Hrs/Wk
2
Compensation
$0
Related Orgs
$0
Other
$0
J Christopher Reyes
Trustee
$0
Hrs/Wk
3
Compensation
$0
Related Orgs
$0
Other
$0
James C Parsons
Trustee
$0
Hrs/Wk
2
Compensation
$0
Related Orgs
$0
Other
$0
James F Flaherty Iii
Fellow & Trustee
$0
Hrs/Wk
3
Compensation
$0
Related Orgs
$0
Other
$0
James J Dunne Iii
Trustee
$0
Hrs/Wk
3
Compensation
$0
Related Orgs
$0
Other
$0
Jennifer F Scanlon
Trustee
$0
Hrs/Wk
3
Compensation
$0
Related Orgs
$0
Other
$0
John B Veihmeyer
Fellow & Trustee
$0
Hrs/Wk
3
Compensation
$0
Related Orgs
$0
Other
$0
John J Brennan
Fellow & Trustee
$0
Hrs/Wk
4
Compensation
$0
Related Orgs
$0
Other
$0
John J Coyle
Trustee
$0
Hrs/Wk
2
Compensation
$0
Related Orgs
$0
Other
$0
Justin R Liu
Trustee
$0
Hrs/Wk
2
Compensation
$0
Related Orgs
$0
Other
$0
Karen Mccartan Desantis
Trustee
$0
Hrs/Wk
2
Compensation
$0
Related Orgs
$0
Other
$0
Kathryn A Koch
Trustee
$0
Hrs/Wk
2
Compensation
$0
Related Orgs
$0
Other
$0
Kenneth C Ricci
Trustee
$0
Hrs/Wk
3
Compensation
$0
Related Orgs
$0
Other
$0
Lois K Folger
Trustee
$0
Hrs/Wk
2
Compensation
$0
Related Orgs
$0
Other
$0
Martin W Rodgers
Trustee
$0
Hrs/Wk
2
Compensation
$0
Related Orgs
$0
Other
$0
Michael G O'Grady
Trustee
$0
Hrs/Wk
2
Compensation
$0
Related Orgs
$0
Other
$0
Nathan O Hatch
Trustee
$0
Hrs/Wk
2
Compensation
$0
Related Orgs
$0
Other
$0
Paulita A Pike
Trustee
$0
Hrs/Wk
2
Compensation
$0
Related Orgs
$0
Other
$0
Phyllis W Stone
Trustee
$0
Hrs/Wk
2
Compensation
$0
Related Orgs
$0
Other
$0
Raul R Romero
Trustee
$0
Hrs/Wk
2
Compensation
$0
Related Orgs
$0
Other
$0
Rev Daniel G Groody Csc Mdiv Phd
VP & Associate Provost, Fellow & Trustee
$319.9K
Hrs/Wk
40
Compensation
$302.8K
Related Orgs
$0
Other
$17.1K
Rev Gregory P Haake Csc Mdiv Phd
Associate Professor, Fellow & Trustee
$172.4K
Hrs/Wk
40
Compensation
$151.7K
Related Orgs
$0
Other
$20.7K
Rev Jose E Ahumada F Csc
Trustee
$0
Hrs/Wk
2
Compensation
$0
Related Orgs
$0
Other
$0
Rev Thomas P Looney Csc
Fellow & Trustee
$0
Hrs/Wk
2
Compensation
$0
Related Orgs
$0
Other
$0
Rev William M Lies Csc
Fellow & Trustee
$0
Hrs/Wk
2
Compensation
$0
Related Orgs
$0
Other
$0
Sara Martinez Tucker
Fellow & Trustee
$0
Hrs/Wk
3
Compensation
$0
Related Orgs
$0
Other
$0
Scott A Dahnke
Trustee
$0
Hrs/Wk
2
Compensation
$0
Related Orgs
$0
Other
$0
Shayla Keough Rumely
Fellow & Trustee
$0
Hrs/Wk
2
Compensation
$0
Related Orgs
$0
Other
$0
Stephanie A Gallo
Trustee
$0
Hrs/Wk
3
Compensation
$0
Related Orgs
$0
Other
$0
Stephen J Brogan
Fellow & Trustee
$0
Hrs/Wk
2
Compensation
$0
Related Orgs
$0
Other
$0
Tanya M Kne
Trustee
$0
Hrs/Wk
2
Compensation
$0
Related Orgs
$0
Other
$0
Thomas G Maheras
Trustee
$0
Hrs/Wk
3
Compensation
$0
Related Orgs
$0
Other
$0
Tracy D Graham
Trustee
$0
Hrs/Wk
2
Compensation
$0
Related Orgs
$0
Other
$0