University Of Notre Dame Du Lac

RADIATION AND PHOTOCHEMISTRY IN THE CONDENSED PHASE AND AT INTERFACES

TAS::89 0227::TAS RECOVERY; RECOVERY ACT - MATERIALS SCIENCE OF ACTINIDES -- EFRC; PI - PETER BURNS

RAFIATION AND PHOTOCHEMISTRY IN THE CONDENSED PHASE

SUPPORTING HOLISTIC AND ACTIONABLE RESEARCH IN EDUCATION (SHARE)

SII-CENTER: SPECTRUMX ? AN NSF SPECTRUM INNOVATION CENTER

NSF CENTER FOR COMPUTER-ASSISTED SYNTHESIS -THE NSF CENTER FOR COMPUTER ASSISTED SYNTHESIS (CCAS) IS A NEXUS OF COLLABORATION, INNOVATION, AND EDUCATION THAT BRINGS TOGETHER DATA SCIENCE AND CHEMICAL SYNTHESIS. THE HIGHLY INTERDISCIPLINARY CCAS TEAM, COMPOSED OF SYNTHETIC ORGANIC CHEMISTS, COMPUTATIONAL CHEMISTS, AND COMPUTER SCIENTISTS, IS DEVELOPING DATA SCIENCE TOOLS AND COMPUTATIONAL WORKFLOWS THAT WILL LIKELY SHAPE THE FUTURE OF SYNTHETIC CHEMISTRY AND THE FIELDS IT ENABLES, SUCH AS MEDICINE, MATERIALS SCIENCE, AND ENERGY RESEARCH. THIS SITE?S IMPACTS ARE BEING FURTHER AMPLIFIED BY AN EXTENSIVE NETWORK OF ACADEMIC, INDUSTRIAL AND NON-PROFIT PARTNERS AND RESEARCH CENTERS, AND ITS DATA CHEMISTRY TOOLS ARE BEING SHARED WITH THE RESEARCH COMMUNITY THROUGH OPEN-SOURCE CLEARINGHOUSES. ALL OF THIS PROVIDES CCAS WITH A UNIQUE OPPORTUNITY TO DEVELOP, EXCHANGE, AND EVALUATE IDEAS IN THE FIELD OF DATA CHEMISTRY, AND ITS SHARED TOOLS AND TRAINING WILL EMPOWER STUDENTS, PRACTICING CHEMISTS, AND THE CHEMICAL INDUSTRY TO EFFECTIVELY APPLY DATA SCIENCE TO THEIR OWN CHEMICAL RESEARCH. LED BY ORGANIC CHEMISTS AT EVERY STAGE, CCAS FOCUSES ON USE-INSPIRED DATA SCIENCE RESEARCH THAT DRIVES THE DEVELOPMENT OF NEW DATA TYPES AND MACHINE LEARNING (ML) METHODS THAT ENABLE THE DISCOVERY OF NOVEL REACTIONS AND YIELD NEW SCIENTIFIC INSIGHTS. THE FOUR SCIENTIFIC THRUSTS INCLUDE (I) DEVELOPING EFFECTIVE ML TOOLS FOR OPTIMIZING CHEMICAL REACTIONS, (II) GAINING MECHANISTIC UNDERSTANDING THROUGH INTERPRETABLE STATISTICAL MODELS AND ELECTRONIC STRUCTURE CALCULATIONS, (III) PREDICTING REACTION OUTCOMES TO ANTICIPATE AND DISCOVER NEW REACTIVITY AND (IV) INTEGRATING THESE TOOLS FOR THE EFFICIENT PLANNING AND EXECUTION OF MULTISTEP SYNTHESES OF COMPLEX MOLECULES. TO ACCOMPLISH THESE GOALS, THREE THEMES ARE INTERWOVEN INTO EACH OF THE THRUSTS: (A) NEW STRUCTURED DATA TYPES THAT ARE AMENABLE TO HIGH-THROUGHPUT EXPERIMENTATION AND PREDICTIVE MODELS FROM THE GROUND UP, GOING BEYOND THE INFORMATION FROM COMMONLY USED DATABASES, (B) MOLECULAR AND REACTION REPRESENTATIONS THAT BRIDGE DESCRIPTOR-BASED AND STRUCTURE-BASED DEEP LEARNING PARADIGMS, AND (C) ALGORITHMS SPECIFICALLY DESIGNED FOR THE LOW DATA REGIMES PREVALENT THROUGHOUT CHEMISTRY. THROUGH THESE INTEGRATED RESEARCH THEMES AND THRUSTS, CCAS CONSTRUCTS AND SHARES DATA CHEMISTRY PLATFORMS THAT ARE EXPECTED TO ENABLE CHEMISTS TO TACKLE AMBITIOUS CHALLENGES THAT THE FIELD IS CURRENTLY UNDER-EQUIPPED TO PURSUE. THE DATA CHEMISTRY PLATFORM ALSO WILL OPEN UP NEW OPPORTUNITIES IN UNDERGRADUATE AND GRADUATE EDUCATION, AND THROUGH PARTNERSHIPS WITH THE DATA CHEMISTS NETWORK AND RESEARCH OPPORTUNITIES FOR CHEMISTS WITH DISABILITIES, CCAS SEEKS TO BROADEN THE PARTICIPATION OF RESEARCHERS FROM UNDERREPRESENTED GROUPS. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

HARNESSING THE POWER OF EXPERIMENTAL GENETIC CROSSES AND SYSTEMS GENETICS TO PROBE DRUG RESISTANCE IN MALARIA

PFC: JOINT INSTITUTE FOR NUCLEAR ASTROPHYSICS, JINA

UNIVERSITY OF NOTRE DAME SSAA PROGRAM: ''ACTINIDE CENTER OF EXCELLENCE'' MOD 0000 INCREMENTALLY FUNDS BUDGET PERIOD 1.

MERLIN - EXPANDING THE REACH OF IMPACT EVALUATION

WOU-MMA: NUCLEAR PHYSICS AT THE NOTRE DAME NUCLEAR SCIENCE LABORATORY PROVIDING A WINDOW ON THE UNIVERSE -THIS AWARD CONTINUES THE RESEARCH PROGRAM OF EIGHT FACULTY MEMBERS AND THEIR STUDENTS IN NUCLEAR STRUCTURE PHYSICS AND NUCLEAR ASTROPHYSICS AT THE UNIVERSITY OF NOTRE DAME. THE PROGRAM FOCUSES ON DIRECT MEASUREMENTS OF NUCLEAR REACTION AND DECAY PROCESSES THAT DETERMINE THE LIFE OF STARS, THE ORIGIN OF THE ELEMENTS, AND PRODUCTION OF MULTI MESSENGERS THAT PROVIDE A WINDOW ON THE UNIVERSE. THIS PROGRAM ADDRESSES KEY NUCLEAR PROCESSES THAT DEFINE THE TIMESCALES OF STELLAR EVOLUTION AND EXPLOSION PROCESSES. ANOTHER COMPONENT IS THE STUDY OF LOW ENERGY FUSION REACTIONS DURING THE LAST DAYS OF A STELLAR LIFE PRIOR TO SUPERNOVA EXPLOSION. THE PROGRAM ALSO EXPLORES THE NUCLEAR STRUCTURE EFFECTS THAT ARE GUIDING LARGE SCALE NUCLEOSYNTHESIS PROCESSES. THE RESEARCH IS PERFORMED PRIMARILY BY USING THE ACCELERATORS OF THE NUCLEAR SCIENCE LABORATORY (NSL) AT THE UNIVERSITY OF NOTRE DAME, WHICH ARE UNIQUELY DESIGNED TO PROBE STELLAR REACTIONS THROUGH A NUMBER OF EXPERIMENTAL TECHNIQUES. THE EXPERIMENTAL RESULTS EXPAND OUR KNOWLEDGE OF THE FUNDAMENTAL STRUCTURE OF THE NUCLEUS AS A MULTI-BODY QUANTUM SYSTEM; THEY ALSO PROVIDE NEW INSIGHT FOR THE ASTROPHYSICS COMMUNITY ON THE ORIGIN OF THE ELEMENTS AND THE CHEMICAL EVOLUTION OF THE COSMOS FROM THE BIG BANG TO THE PRESENT. THE NSL IS UNIQUELY EQUIPPED FOR PERFORMING THIS KIND OF RESEARCH IN A UNIVERSITY ENVIRONMENT. THE AWARD WILL SUPPORT THE TRAINING OF A LARGE NUMBER OF GRADUATE (APPROXIMATELY 25) AND UNDERGRADUATE STUDENTS (APPROXIMATELY 20) IN EXPERIMENTAL AND THEORETICAL TECHNIQUES TO BE READY TO JOIN THE NUCLEAR WORKFORCE OF THE NATION. THE EXPERIMENTAL PROGRAM IS BASED ON THE USE OF TWO ACCELERATORS AT THE NSL. INTENSE STABLE ION BEAMS FROM THE SINGLE ENDED 5U PELLETRON ARE USED FOR THE DIRECT STUDY OF LOW-ENERGY CAPTURE AND FUSION REACTIONS. HEAVY ION BEAMS ARE USED TO INVESTIGATE SUCH REACTIONS IN INVERSE KINEMATIC TECHNIQUE USING THE ST. GEORGE RECOIL SEPARATOR. THIS SEPARATOR IS UNIQUE AND SERVES AS A BLUEPRINT FOR THE DESIGN OF THE SECAR SEPARATOR AT FRIB. THE FN TANDEM ACCELERATOR IS USED AS A MULTI-PURPOSE INSTRUMENT. IT IS OPERATED AS A DRIVER FOR THE PRODUCTION OF RADIOACTIVE BEAMS AT THE NEWLY-EXPANDED TRISOL FACILITY, THE NATION'S FIRST DEDICATED INSTRUMENT FOR PRODUCING LOW ENERGY RADIOACTIVE BEAMS. THESE BEAMS ALLOW DIRECT REACTION MEASUREMENTS WITH AND THE TRAPPING OF LIGHT RADIOACTIVE PARTICLES AT LEVELS NOT POSSIBLE AT LARGE NATIONAL FACILITIES. THE FN ALSO SERVES THE ACCELERATOR MASS SPECTROMETRY (AMS) PROGRAM AT THE NSL, TESTING GEOLOGICAL AND COSMOLOGICAL SAMPLES FOR LONG-LIVED RADIOACTIVITIES. A LARGE NUMBER OF NUCLEAR STRUCTURE EXPERIMENTS ARE BASED ON THE OPERATION OF THIS MACHINE USING A VARIETY OF PARTICLE AND GAMMA SPECTROSCOPY TECHNIQUES. A SMALLER FRACTION OF THE PROGRAM RELIES ON THE USE OF OTHER NATIONAL AND INTERNATIONAL FACILITIES TO TAKE ADVANTAGE OF HIGHER ENERGY AND MORE EXOTIC BEAMS NOT AVAILABLE AT THE NSL. THIS PROJECT ADVANCES THE OBJECTIVES OF WINDOWS ON THE UNIVERSE: THE ERA OF MULTI-MESSENGER ASTROPHYSICS, ONE OF THE 10 BIG IDEAS FOR FUTURE NSF INVESTMENTS. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

CENTER FOR SHOCK WAVE-PROCESSING OF ADVANCED REACTIVE MATERIALS (C-SWARM)

STRONG BEGINNINGS: LEVERAGING THE HOME, SCHOOL, AND CHURCH TO DEVELOP THE WHOLE CHILD IN HAITI.

WOU-MMA: NUCLEAR PHYSICS AT THE NOTRE DAME NUCLEAR SCIENCE LABORATORY PROVIDING A WINDOW ON THE UNIVERSE

FATIMA: FOG AND TURBULENCE INTERACTIONS IN THE MARINE ATMOSPHERE

MOUNTAIN TERRAIN ATMOSPHERIC MODELING AND OBSERVATIONS (MATERHORN)PROGRAM

INDUCIBLE ANTIBIOTIC RESISTANCE IN METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS

QUARKNET

NUCLEAR STRUCTURE AND NUCLEAR ASTROPHYSICS

NEW START GRANT

GRADUATE RESEARCH FELLOWSHIP PROGRAM (GRFP)

NUCLEAR STRUCTURE AND NUCLEAR ASTROPHYSICS

READ HAITI: SCALING EARLY GRADE READING IMPROVEMENT IN HAITI

III-N DEVICES AND ARCHITECTURES FOR TERAHERTZ ELECTRONICS

NUCLEAR STRUCTURE AND NUCLEAR ASTROPHYSICS

TAS::89 0336::TAS RECOVERY GLOBAL WARMING POTENTIAL (GWP) OF CURRENT REFRIGERANTS IS MORE THAN 1000 TIMES THE GWP OF CO2. THIS MAKES CO2 VERY ATTR

21-ULI STEP-B-0052 A SAFETY-AWARE ECOSYSTEM OF INTERCONNECTED AND REPUTABLE SUAS

TAS::89 0336::TAS RECOVERY A RECENT DISCOVERY BY NOTRE DAME HAS IDENTIFIED A CLASS OF IONIC LIQUID MATERIALS WHICH UNDERGO A PHASE TRANSITION FROM

NOVEL OXADIAZOLS FOR THE TREATMENT OF DRUG-RESISTANT GRAM-POSITIVE BACTERIA

NUCLEAR PROPERTIES AT EXTREME DENSITY, TEMPERATURE, SPIN AND ISOSPIN

BROAD AGENCY ANNOUNCEMENT (BAA) UNDER THE MEDIA LITERACY FOR NEW DIGITAL ARRIVALS

GRADUATE RESEARCH FELLOWSHIP PROGRAM (GRFP) -THE NATIONAL SCIENCE FOUNDATION (NSF) GRADUATE RESEARCH FELLOWSHIP PROGRAM (GRFP) IS A HIGHLY COMPETITIVE, FEDERAL FELLOWSHIP PROGRAM. GRFP HELPS ENSURE THE VITALITY AND DIVERSITY OF THE SCIENTIFIC AND ENGINEERING WORKFORCE OF THE UNITED STATES. THE PROGRAM RECOGNIZES AND SUPPORTS OUTSTANDING GRADUATE STUDENTS WHO ARE PURSUING RESEARCH-BASED MASTER'S AND DOCTORAL DEGREES IN SCIENCE, TECHNOLOGY, ENGINEERING, AND MATHEMATICS (STEM) AND IN STEM EDUCATION. THE GRFP PROVIDES THREE YEARS OF FINANCIAL SUPPORT FOR THE GRADUATE EDUCATION OF INDIVIDUALS WHO HAVE DEMONSTRATED THEIR POTENTIAL FOR SIGNIFICANT RESEARCH ACHIEVEMENTS IN STEM AND STEM EDUCATION. THIS AWARD SUPPORTS THE NSF GRADUATE FELLOWS PURSUING GRADUATE EDUCATION AT THIS GRFP INSTITUTION. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

"(HEL-MRI FY07) AIRBORNE AERO-OPTICS LABORATORY (AAOL)"

NUCLEAR STRUCTURE AND NUCLEAR ASTROPHYSICS

THE PURPOSE OF THIS AWARD IS TO INITIATE A LOW FORCE FRICTION WELDING PROJECT SUBMITTED BY THE UNIVERSITY OF NOTRE DAME IN COLLABORATION WITH MANUFACTURING TECHNOLOGY, INC. (MTI). THE PROJECT GOAL IS TO DEMONSTRATE THE SUPERIOR JOINT PERFORMANCE OF THE LOW FORCE FRICTION WELDING TECHNOLOGY, AS COMPARED TO CURRENT THERMITE AND EFB WELDING TECHNOLOGIES, WHEN APPLIED TO CONTINUOUSLY WELDED 136LB AREMA RAIL. THE PROJECT OBJECTIVES ARE TO 1) EVALUATE THE CURRENT STATE OF THE ART IN RAIL WELDING, 2) CONDUCT A FEASIBILITY STUDY OF LOW FORCE FRICTION WELDING USING PRISMATIC COUPONS, 3) STUDY THE PERFORMANCE OF LOW FORCE FRICTION WELDING ON 60LB AREMA RAIL USING AN EXISTING MACHINE AT MTI, 4) DESIGN, BUILD, AND RUN-OFF A LOW FORCE FRICTION WELDING MACHINE CAPABLE OF FABRICATING 136LB AREMA RAIL, 5) STUDY THE PERFORMANCE OF LOW FORCE FRICTION WELDING ON 136LB AREMA RAIL USING THIS NEW MACHINE, AND 6) DISSEMINATE KNOWLEDGE OF LOW FORCE FRICTION WELDING TO THE FRA TRANSPORTATION TECHNOLOGY CENTER TO POTENTIALLY INITIATE AN IN-TRACK TESTING IN A PHASE AFTER THE END OF THIS GRANTS PERIOD OF PERFORMANCE. THE RAIL COMMUNITY AT-LARGE WILL BENEFIT FROM THIS PROJECT.

(R)-ND-336 FOR THE TREATMENT OF DIABETIC FOOT ULCERS

DECODING THE REGULATION OF PROTEIN FOLDING BY SYNONYMOUS CODON USAGE - PROJECT SUMMARY - DECODING THE REGULATION OF PROTEIN FOLDING BY SYNONYMOUS CODON USAGE SYNONYMOUS MUTATIONS ARE WIDESPREAD IN COMPLEX, POLYGENIC DISEASES BUT ARE TYPICALLY REGARDED AS PHENOTYPICALLY SILENT, AS THEY PRESERVE THE AMINO ACID SEQUENCE OF THE ENCODED PROTEIN. YET, SYNONYMOUS MUTATIONS CAN SIGNIFICANTLY PERTURB PROTEIN HOMEOSTASIS THROUGH A VARIETY OF MECHANISMS, INCLUDING PERTURBING THE FOLDING MECHANISM OF THE ENCODED PROTEIN. RECENTLY, MY LAB DISCOVERED THAT SYNONYMOUS CODON-INDUCED CHANGES TO PROTEIN FOLDING CAN BE LARGE ENOUGH TO (A) EXCEED THE PROTEIN HOMEOSTATIC BUFFERING PROVIDED BY MOLECULAR CHAPERONES AND (B) LEAD TO A DRAMATIC TWO-FOLD DECREASE IN CELL GROWTH RATE. FOR THESE PROTEINS, CHANGING THE CODON USAGE PATTERN PRODUCES A FOLDED PROTEIN WITH AN ALTERED STRUCTURE, WHICH LEADS TO CHANGES IN ACTIVITY AND/OR SUSCEPTIBILITY TO DEGRADATION BY CELLULAR PROTEASES. THE PROFOUND IMPLICATION OF THESE RESULTS IS THAT CODON USAGE REPRESENTS ANOTHER LEVEL OF INFORMATION ENCODED WITHIN GENOMES, LINKING TOGETHER “SILENT” GENETIC DIFFERENCES WITH PROPER PROTEIN FUNCTION AND REGULATION OF A POTENTIALLY BROAD RANGE OF CELLULAR MECHANISMS. HISTORICALLY, HOWEVER, STUDYING PERTURBATIONS TO PROTEIN FOLDING MECHANISMS IN VIVO HAS PRESENTED IMMENSE TECHNICAL CHALLENGES. FOR THIS REASON, TO DATE ONLY A FEW EXAMPLES HAVE BEEN IDENTIFIED OF CONNECTIONS BETWEEN CODON USAGE AND PROTEIN FOLDING. AS A RESULT, WE LACK A COMPREHENSIVE PICTURE OF THE EXTENT TO WHICH SYNONYMOUS CODON USAGE CONTRIBUTES TO THE PRODUCTION OF A FUNCTIONAL PROTEOME AND HOW SYNONYMOUS MUTATIONS PERTURB PROTEIN HOMEOSTASIS. THIS PIONEER AWARD PROJECT IS DESIGNED TO BREAK THROUGH EXISTING TECHNICAL CHALLENGES, DEVELOPING A NOVEL APPROACH TO (I) BROADLY MEASURE FOR THE FIRST TIME THE NUMBER AND TYPES OF PROTEINS WITH FOLDING MECHANISMS SENSITIVE TO SYNONYMOUS CODON USAGE, ACROSS AN ENTIRE PROTEOME AND (II) DEEPLY INTERROGATE WHICH CODON USAGE PATTERNS AND FEATURES BEST SUPPORT PROPER PROTEIN FOLDING IN VIVO. THE AMBITIOUS, OVERARCHING GOAL OF THIS PROJECT IS TO ENABLE A NEXT GENERATION OF GENOMIC INFERENCE BY DEVELOPING A PREDICTIVE UNDERSTANDING OF THE SYNONYMOUS CODON USAGE PATTERNS THAT BEST SUPPORT PRODUCTION OF A FUNCTIONAL PROTEOME AND THE DYSREGULATION THAT LEADS TO HUMAN GENETIC DISEASE.

NOTRE DAME STUDY OF RESILIENCY IN LATER LIFE

CHARACTERIZATION OF BIOFILMS BY CORRELATED MASS SPECTROMETRIC AND RAMAN IMAGING

TAS::57 3600::TAS "AIRBORNE AERO-OPTICS LABORATORY-TRANSONIC (AAOL-T)" DATED, 01 FEB 2012 AND REVISED BUDGET 14 SEP 2012"

PLASMINOGEN AND PLASMIN: STRUCTURE AND FUNCTION

DESIGN, SYNTHESES AND STUDIES OF NOVEL ANTITUBERCULOSIS AGENTS

INTEGRATING CIVIL DISCOURSE INTO THE CURRICULUM AT PUBLIC, PRIVATE, COMMUNITY AND HISTORICALLY MINORITY-SERVING COLLEGES AND UNIVERSITIES

HIGH CAPACITY PROTEIN PURIFICATION FOR STRUCTURAL IMMUNOLOGY

MOLECULAR PROBES FOR BIOMEMBRANE RECOGNITION

BIOLOGICALLY-INSPIRED CNN IMAGE PROCESSORS WITH DYNAMICALLY-INTEGRATED HYPERSPECTRAL NANOSCALE SENSORS

BUILDING BETTER T CELL RECEPTORS FOR TARGETED IMMUNOTHERAPY